JPH06271472A - Antiviral composition and its production - Google Patents

Abstract

PURPOSE:To provide an antiviral composition applicable not only to pharmaceuticals but also to molded articles of resin and rubber and capable of keeping antibacterial and antiviral actions over a long period. CONSTITUTION:A thiosulfato complex salt and a thiosulfato salt of at least one kind of metal selected from silver, copper and zinc are supported on a porous carrier. A part of the surface of the carrier is coated with silicon dioxide produced by the hydrolysis of an alkoxysilane.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an antiviral composition applied to a wide range of living environments such as medical devices and medicines, hygiene products and cooking products.

[0002]

Conventionally, there have been chemotherapeutic agents such as 1-adamantanamine hydrochloride, thiosemicarbazide, arabinosyl nucleoside, nucleoside, 2 ', 3'-dideoxynucleoside, and pyrophosphate derivative as antiviral agents.
Furthermore, there were hygiene products such as sanitary sack which was directly mixed with metals such as silver and copper or metal salts as antibacterial / antiviral agents.

[0003]

However, the conventional antiviral agents described above cannot be used for purposes other than pharmaceuticals because they are effective only against specific viruses and have no antibacterial properties. Further, as an antiviral agent intended for use in a resin molded product, there is no antiviral agent that can withstand the resin molding temperature. Furthermore, in the above-mentioned conventional sanitary products containing the antibacterial / antiviral agent, the antibacterial / antiviral agent is directly mixed in each material. antibacterial·
Since the antiviral agents are directly mixed, it is unavoidable that these agents directly contact the human body and irritate the skin. In addition, antibacterial materials mixed in these materials
It is not possible to control the amount of antiviral agent exerting an antibacterial / antiviral effect on the surface of these materials.

An object of the present invention is to provide an antiviral composition having antibacterial properties, which can be applied not only as a medicine but also to resin molded products, rubber molded products, resin fibers and the like. The present invention also provides an antibacterial / antiviral composition having less skin irritation when the human body does not directly expose components having antibacterial / antiviral effects, and thus the human body touches a mixed resin molded product or the like. To aim. Another object of the present invention is to provide an antibacterial / antiviral composition having a sustained release property and having a prolonged antibacterial / antiviral effect.

[0005]

The antiviral composition of the present invention comprises a thiosulfato complex salt and a thiosulfato salt of at least one metal selected from the group consisting of silver, copper and zinc, and a thiosulfato complex salt and a thiosulfato salt. It comprises a supported porous particle carrier. A preferred antiviral composition of the present invention comprises a thiosulfato silver complex salt and a thiosulfato silver salt, and a porous particle carrier carrying these salts. Here, as the porous particle carrier, inorganic oxide particles such as silica gel, alumina, zeolite, zirconia, montmorillonite are used, and among them, silica gel particles are preferable.

In the antiviral composition of the present invention, the surface of the metal complex salt and the porous particle carrier carrying the metal salt is
At least a part thereof is preferably covered with a coating layer. The area, thickness, porosity, etc. of the coating layer control the elution rate of the salt carried on the carrier.
As one of the methods for forming the coating layer, there is a method for forming the coating layer of silicon dioxide by a sol-gel method in which water is added to an alcohol solution of alkoxysilane and hydrolyzed. As the alkoxysilane and alcohol, those having an alkyl group having 1 to 4 carbon atoms are preferable. By forming this coating layer, the antiviral composition has preferable sustained release properties. Therefore, the influence of environmental pollution is extremely small. Further, the thermal stability of the metal salt, particularly the silver salt, supported on the carrier is improved.

Although it is difficult to obtain the thiosulfato metal complex salt and the thiosulfato metal salt of the present invention as a solid by itself, as described below, they are prepared as a water-soluble compound, and the aqueous solution thereof is prepared into a porous material such as silica gel. By impregnating the hydrophilic particle carrier and drying the carrier, the carrier can be immobilized in a state of being supported on the carrier. The thiosulfato metal complex salt and the thiosulfato metal salt can be obtained by adding at least one salt selected from the group consisting of sulfite and hydrogensulfate to an aqueous solution of the metal salt, and then adding thiosulfate. The ratio of the salt used for preparing the thiosulfato metal complex salt and the thiosulfato silver salt is appropriately 2 to 4 mol of sulfate and / or hydrogen sulfate, and 2 to 6 mol of thiosulfate per 1 mol of metal salt. is there. If the amount of sulfate and / or hydrogensulfate and thiosulfate is small, the complex salt is not sufficiently formed, and if it is too large, it causes discoloration.

The thiosulfato metal salt and the thiosulfato silver salt supported on the porous particle carrier are preferably 1 to 10 parts by weight, particularly 3 to 5 parts by weight, based on 100 parts by weight of the carrier. The larger the amount of the particles carried, the more easily the color changes. The sulfite, hydrogensulfate and thiosulfate are preferably sodium salts, more preferably potassium salts.

An aqueous solution containing the thiosulfato metal complex salt and the thiosulfato metal salt obtained as described above is
This can be used as it is as a bactericidal / viricidal / disinfectant solution having antibacterial / antiviral properties. The disinfection method using this disinfectant solution is a method in which a solution containing a thiosulfato metal complex salt and a thiosulfato metal salt is brought into contact with a pathogenic bacterium to suppress the growth thereof. A more preferable disinfection method is a method in which water, alcohol, or a mixed solution of both, in which the thiosulfato metal complex salt and the porous particle carrier carrying the thiosulfato metal salt are dispersed, is used as the disinfecting solution. The carrier exhibits a bactericidal / viricidal action for a long period because it has a sustained release property with respect to the carried salt. The total amount of the thiosulfato metal complex salt and the thiosulfato metal salt contained in the solution is preferably 1 to 10 g per 100 ml of the solution. The present invention further imparts antiviral properties by incorporating the above antiviral composition into a material for sanitary goods such as a silicone rubber, or a water absorbent body made of hydrophilic polymer powder or fibers.

[0010]

The thiosulfato metal complex salt and the thiosulfato metal salt used in the present invention form radicals in the immediate vicinity thereof due to oxygen in the air, and the radicals affect the membrane surface of microorganisms and the like that are in close proximity to the thiosulfato metal complex salt. Exerts an antiviral effect. That is, the metal complex ion and the metal ion bind to the surface of the virus envelope and the membrane of the bacteria to inhibit the enucleation process of the virus and the reproduction of the bacteria, and at the same time, to inhibit the DNA synthesis, the transcription and the reverse transcriptase, and thus the antibacterial and antibacterial activity. It seems to exert a virus action.

Further, in the disinfectant solution, the use of ethanol as a solvent has the effect of rapidly destroying the lipid membrane component of the bacterium or virus.
A 20-70 wt% ethanol water-ethanol mixture is the preferred solvent. Further, it can be used in combination with other fungicides, and for example, a 20 to 40 wt% aqueous solution of alkyldiaminoethylglycine hydrochloride is preferable. The thiosulfato metal complex salts and thiosulfato metal salts of the present invention include various chemotherapeutic agents such as 1-adamantanamine hydrochloride, thiosemicarbazide, arabinosyl nucleoside, 2 ′,
When used in combination with a 3'-dideoxynucleoside or a pyrophosphate derivative, the antibacterial / antiviral spectrum can be broadened. As a method of using these chemotherapeutic agents in combination, a method of forming an aqueous solution, coordinating with at least one of the salts with a thiosulfato metal complex salt and a thiosulfato metal salt, and supporting it on a porous particle carrier, or a thiosulfato metal complex salt and a thiosulfato metal salt There is a method of mixing with a porous particle carrier carrying a salt.

The antiviral composition of the present invention can impart antibacterial / antiviral properties to various resins, rubbers, resin fibers and the like by mixing them. For example, the silicone rubber of Example 5 is used for a contraceptive condom or a glove, or the moisture-absorbing powder of Example 6 is used as a sanitary product. An antiviral ointment can be obtained by mixing with an ointment base such as petrolatum.

[0013]

The preferred embodiments of the present invention will be described in detail below. The antibacterial / antiviral composition of the present invention comprises a porous particle carrier and a thiosulfato complex salt or thiosulfato salt of silver, copper or zinc supported on the porous particle carrier.
The most preferred thiosulfato complex salts and thiosulfato salts are silver salts. Also, the preferred carrier has an average particle size of 1
10 μm silica gel particles, especially JIS standard Z
It is B-type silica gel defined by 0701. Above all, the moisture absorption rate is 20% under low humidity (25 ° C) where the relative humidity is 50% or less.
Below, it is preferable that the moisture absorption rate is 50% under high humidity (25 ° C.) with relative humidity of 90% or more. This silica gel absorbs little moisture under low humidity and has a large moisture absorption under high humidity. Such an antibacterial / antiviral agent supported on silica gel does not easily volatilize and is stable to heat, and therefore exhibits an antibacterial / antiviral effect for a long period of time.
Moreover, silica gel is transparent and its refractive index is similar to that of synthetic resins. Therefore, even if silica gel carrying an antibacterial / antiviral agent is kneaded with a synthetic resin or the like, its color is not changed.

The preferred antiviral composition of the present invention is
For example, it is manufactured as follows. First, an aqueous solution of silver thiosulfato and a silver thiosulfato complex salt is prepared by adding sodium sulfite and sodium thiosulfate to an aqueous solution of silver acetate. Next, this aqueous solution is impregnated into a porous carrier such as silica gel and dried to immobilize the thiosulfato silver and the silver thiosulfato silver complex salt supported on the carrier. Although it is not clear in what form of the silver compound the silver salt is supported on the carrier, this silver compound can be identified by an X-ray diffraction image using Kα ray of Cu.

FIG. 1 shows this X-ray diffraction image, which is shown in JCPDS together with the diffraction line (marked with ●) of silver oxide (Ag ₂ O).
(Joint Committee on Power
Diffraction Standards)
Diffraction image that is not recognized in the image, that is, 1 with a diffraction angle of 2θ
0.3 °, 11.2 °, 11.9 ° and 12.3 ° (these 2θ values are respectively referred to as P ₁ , P ₂ , P ₃ and P ₄
Express with. ) Clearly has a diffraction intensity. The circles indicate the diffraction lines of sodium sulfate (Na ₂ SO ₄ ). When the drying temperature is raised in the step of supporting the silver salt on the carrier, the X-ray diffraction intensity peculiar to the silver compound cannot be recognized. FIG. 1 shows a drying temperature of 100.
4 shows an X-ray diffraction pattern of the antiviral composition obtained at a temperature of 0 ° C. or lower. In addition, FIG. 2 shows a product dried by heating at 240 ° C. for 10 minutes, and FIG. 3 shows a product dried by heating at 240 ° C. for 30 minutes.
Fig. 4 shows the X of each product that was heated and dried at 500 ° C for 5 minutes.
The line diffraction image is shown.

When the heating temperature exceeds 200 ° C., Ag ₂ O
And the X-ray diffraction intensities in P _{1 to} P _{4 become} gradually smaller. In the case of heating at 500 ° C., the diffraction intensity other than Na ₂ SO ₄ cannot be recognized probably because the silver compound sublimes. In addition to having the X-ray diffraction image as shown in FIG. 1, it has antibacterial / antiviral effects as described below, and as shown in FIG. 2, the diffraction intensities at P _{1 to} P ₄ are small, and they are almost equal. However, a clear diffraction intensity is recognized in P _{1 to} P ₄ . Those showing X-ray diffraction images as shown in FIGS. 3 and 4 have no antibacterial / antiviral effect at all.

The sulfite salt, hydrogen sulfate salt and thiosulfate salt used in preparing the above-mentioned silver thiosulfato complex salt and thiosulfato silver salt are sodium salts, but an antiviral composition obtained when a potassium salt is used. The X-ray diffraction image of is shown in FIG. Diffraction images not recognized by JCPDS, that is, 8.7 °, 9.4 °, 9.8 with diffraction angle 2θ.
It can be seen that it has diffraction intensities at ° and 11.2 °. The difference from FIG. 1 is that the diffraction angle having a characteristic diffraction intensity is shifted to the smaller side. In addition,
Although the diffraction line of silver oxide (Ag ₂ O) is not clearly observed, the diffraction lines of potassium sulfate (K ₂ SO ₄ ) and K ₂ S ₄ O ₆ are recognized.

As described above, the thiosulfato silver complex salt and the thiosulfato silver salt to be supported on the porous particle carrier are water-soluble silver salts, for example, silver acetate, an aqueous solution of silver nitrate, and a group consisting of sulfite and hydrogen sulfate. It can be obtained by adding at least one salt selected from and thiosulfate. 2 to 4 mol of sulfite and / or hydrogensulfate, and 2 to 6 thiosulfate per mol of silver salt
Molar is preferred. In the solution thus prepared, thiosulfato ion and silver ion together with [A
Silver thiosulfato complex ions such as g (S ₂ O ₃ )] ³⁻ and [Ag ₂ (S ₂ O ₃ )] ²⁻ coexist. Since this solution does not produce a noticeable white turbidity even when contacted with tap water containing chlorine, it is considered that most silver ions form complex ions. In any case, it exhibits antibacterial and antiviral effects in the coexisting state of ions as described above. The supported amount of these thiosulfato silver complex salt and thiosulfato silver salt on the porous particle carrier is preferably 1 to 10 parts by weight, more preferably 2 to 5 parts by weight, relative to 100 parts by weight of the carrier.

[Example 1] 0.232 g of silver acetate was dissolved in 30 ml of deionized water to obtain 0.627 g of potassium sulfite.
Add and dissolve with stirring. Then potassium thiosulfate K ₂
Add 1.540 g of S ₂ O ₃ and dissolve with stirring. Thus
An aqueous solution of thiosulfato silver complex salt and thiosulfato silver salt is prepared. In the present example, B-type silica gel powder described in "JIS Z 0701 Silica gel desiccant for packaging" is used as the porous carrier for adsorbing the above aqueous solution. This B-type silica gel powder is a silica gel powder having a low moisture absorption rate under low humidity, a high moisture absorption rate under high humidity, and a high total moisture absorption amount at high humidity. Here, a particle size of 2 to 30 μm (average particle size: 8 μm) is used. The silica gel powder is dried at 180 ° C. for 2 hours or more and then at 60 ° C. for 24 hours.

Next, 100 parts by weight of the silica gel is mixed with the aqueous solution so that the silver component is 2 parts by weight, and then heated at 60 ° C. under reduced pressure to quickly remove water. Then, this is ground to a particle size of 2 to 30 μm. Thus, silica gel carrying silver thiosulfato complex salt and silver thiosulfato is obtained. Next, 100 parts by weight of the silica gel is dispersed in a solution prepared by dissolving 100 parts by weight of tetraethoxysilane in 100 parts by weight of ethyl alcohol, and pure water is added to this to hydrolyze the tetraethoxysilane. At least a portion of the surface of the silica gel is coated with the resulting silicon dioxide coating, which is then dried.

Example 2 200 mg of silver acetate was added to about 50
After dissolving in 30 ml of pure water at 60 ° C. and filtering to remove the dissolution residue, 1 g of potassium sulfite and 1.8 were added to the filtrate.
g of potassium thiosulfate are sequentially added and dissolved. Add "JIS Z 0701 silica gel desiccant for packaging" to this solution.
Silica gel carrying the thiosulfato silver complex salt and the thiosulfato silver salt is obtained by adding the type B silica gel described above having an average particle size of about 2.6 μm, mixing and drying under reduced pressure. [Example 3] 0.272 of copper acetate in 30 ml of deionized water
g is dissolved, 1.0 g of potassium sulfite is added, and dissolved by stirring. Then, 0.66 g of potassium thiosulfate K ₂ S ₂ O ₃ .5H ₂ O is added and dissolved by stirring. Thus, an aqueous solution of the thiosulfato copper complex salt and the thiosulfato copper salt is prepared. Next, in the same manner as in Example 1, thiosulfato copper complex salt and thiosulfato copper salt were supported on silica gel,
A part of the surface of the silica gel is covered with a silicon dioxide film.

[Example 4] 0.286 g of zinc acetate was dissolved in 30 ml of deionized water, 1.0 g of potassium sulfite was added, and the mixture was dissolved with stirring. Then potassium thiosulfate K ₂ S ₂
Add 0.66 g of O ₃ .5H ₂ O and dissolve with stirring. Thus, an aqueous solution of the thiosulfato zinc complex salt and the thiosulfato zinc salt is prepared. Next, in the same manner as in Example 1,
The thiosulfato zinc complex salt and the thiosulfato zinc salt are supported on silica gel, and a part of the surface of the silica gel is covered with a silicon dioxide film. Example 5 A rubber obtained by kneading 3% by weight of the composition obtained in Example 1, that is, silica gel particles carrying silver thiosulfato and silver thiosulfato complex salt and having a surface coated with a silicon dioxide film, having a particle size of 2 μm or less. The material is molded and crosslinked to form a silicone rubber thin film.

[Example 6] Methyl acrylate and vinyl acetate (5 g each) were subjected to suspension polymerization in 10 ml of benzene to give 10
After dispersion in ml of methanol, 1 g of silica gel particles carrying the silver thiosulfato complex salt and silver thiosulfato salt of Example 2 are added. This suspension is saponified with a 40% by weight aqueous solution of NaOH, washed with acetone and dried to remove water, thereby obtaining a water-absorbing powder. [Example 7] 3% by weight of silica gel particles carrying the silver thiosulfato complex salt and the silver salt of thiosulfato of Example 2 are mixed with petrolatum which is an ointment base.

[Example 8] L was added to an aqueous solution of the thiosulfato silver complex salt and the thiosulfato silver salt prepared in Example 1.
Dissolve 10 mmol of adamantanacin hydrochloride. This aqueous solution is adsorbed on the same silica gel particles used in Example 2 and dried under reduced pressure. [Example 9] Silica gel particles 10 supporting a silver thiosulfato complex salt and a silver thiosulfato salt obtained in Example 2
g to 50% by weight of ethanol in a water-ethanol mixed solution 10
Disperse it in 0 ml to prepare a sterilizing / disinfecting solution. [Example 10] Silica gel particles 1 carrying a thiosulfato zinc complex salt and a thiosulfato zinc salt obtained in Example 4
0 g of 50% by weight of ethanol water-ethanol mixture 1
Disperse it in 00 ml to prepare a disinfectant solution. [Example 11] The solution of Example 9 was left at room temperature for one week, and the solution was used as a disinfectant.

Comparative Example 1 A silicone rubber coating is prepared in the same manner as in Example 5 except that silica gel is not mixed. [Comparative Example 2] A water-ethanol mixed solution containing 50% by weight of ethanol is used as a disinfecting solution. [Comparative Example 3] The mixed solution of Comparative Example 2 was allowed to stand at room temperature for 1 week, and the solution was used as a disinfecting solution.

The results of examining the antibacterial / antiviral action using the samples of the above-mentioned examples and comparative examples will be described. For the samples of Examples 1 to 8 and Comparative Example 1, 1 g of each sample and 3 ml of phosphate buffer were shaken for 30 minutes to extract the salt in the sample, and the samples of Examples 9 to 11 and Comparative Example 2
For the samples of 3 above, the disinfecting solutions are used as test solutions. As a virus, poliovirus (polio)
virus: Sabin live vaccine type 1), measles virus: Nagahata
Co., Ltd., AIDS virus (Human Immunode)
ficient virus: JMH-1 type, herpes simplex virus (Herpes simmplex v)
irus: G strain, influenza virus (Infl
uenza virus: Okuda strain) A is used.

1 ml of the test liquid of the examples and comparative examples and TC
1 ml of virus solution with ID ₅₀ (/ 1 ml) 6.5-8.5
30 minutes later, for poliovirus, measles virus and herpes simplex virus, African green monkey kidney-derived Vero cells, for AIDS virus, adult thymocyte leukemia patient MT-4 cells, for influenza virus M from dog kidney
DCK cells were each infected with 10 ⁶ cells / ml, and the infectivity was evaluated by the life and death of the cells after 1 week.
The results are shown in Table 1.

[0028]

[Table 1]

Next, the antibacterial action will be described. Escherichia coli Escherichia coli (Escheric)
hia coli), Staphylococcus aureus (Staphylococcus aur)
eus) and methicillin resistance Staphylococcus aureus
instance staphylococcus a
ureus) is used. 1 ml of each test solution and 10 ⁴ to 1
0 ⁶ CFU / ml of the bacterial solution (1 ml) is mixed, allowed to stand for 30 minutes, then pour on ordinary agar medium (Nissui Pharmaceutical Co., Ltd.), and the number of bacteria after 18 hours of culture is measured. The results are shown in Table 2.

[0030]

[Table 2]

Next, examples in which a thiosulfato complex salt and a thiosulfato salt are used in combination with a chemotherapeutic agent will be described. [Example 12] 1-adamantanamine hydrochloride is added to an aqueous solution containing a silver thiosulfato complex salt and thiosulfato silver to prepare a coordination compound, and the aqueous solution is adsorbed on silica gel particles and dried. [Example 13] To the aqueous solution containing silver thiosulfato complex and silver thiosulfato, thiosemicarbazide is added to prepare its coordination compound, and this aqueous solution is adsorbed on silica gel particles and dried. [Example 14] An arabinosyl nucleoside is added to an aqueous solution containing a silver thiosulfato complex and silver thiosulfato to prepare a coordination compound, and the aqueous solution is adsorbed on silica gel particles and dried.

Example 15 A nucleoside is added to an aqueous solution containing a silver thiosulfato complex salt and silver thiosulfato to prepare a coordination compound, and the aqueous solution is adsorbed on silica gel particles and dried. [Example 16] A coordination compound is prepared by adding 2 ', 3'-dideoxynucleoside to an aqueous solution containing silver thiosulfato complex and silver thiosulfato, and the aqueous solution is adsorbed on silica gel particles and dried. Example 17 A pyrophosphoric acid derivative is added to an aqueous solution containing a silver thiosulfato complex salt and thiosulfato silver to prepare a coordination compound, and the aqueous solution is adsorbed on silica gel particles and dried.

Each sample of Examples 12 to 17 and a phosphate buffer were shaken to extract the compound in the sample to a concentration of about 10 nM / l, and the solution was infected with virus in the same manner as described above. The antiviral property was evaluated. The results are shown in Table 3.
The case where the infectious titer decreased to 10 ^-3 or less is indicated by +, and the case where it was not indicated by-.

[0034]

[Table 3]

In Examples 12 to 15, an example in which a silver salt was coordinated with a chemotherapeutic agent was given, but the same effect as described above can be obtained with a copper salt or a zinc salt coordinated with the chemotherapeutic agent. confirmed.

[0036]

INDUSTRIAL APPLICABILITY As described above, according to the present invention, an antiviral composition which can be applied to resin molded products and rubber molded products and also has an antibacterial effect can be obtained. In addition, by forming a coating layer on the surface of the carrier, it has a sustained release property and maintains an antibacterial / antiviral effect for a long period of time. Furthermore, according to the present invention, an antibacterial / antiviral hygiene article can be obtained.

[Brief description of drawings]

FIG. 1 shows an X-ray diffraction pattern of an antiviral composition according to an example of the present invention.

FIG. 2 shows an X-ray diffraction pattern of the same composition heated at 240 ° C. for 10 minutes.

FIG. 3 shows an X-ray diffraction pattern of the same composition heated at 240 ° C. for 30 minutes.

FIG. 4 X of the same composition heated at 500 ° C. for 5 minutes
A line diffraction pattern is shown.

FIG. 5 shows an X-ray diffraction pattern of the antiviral composition according to another example of the present invention.

 ─────────────────────────────────────────────────── ─── Continuation of the front page (72) Inventor Kenji Hoshino 1006 Kadoma, Kadoma City, Osaka Prefecture Matsushita Electric Industrial Co., Ltd. (72) Atsushi Nishino 1006 Kadoma, Kadoma City, Osaka Matsushita Electric Industrial Co., Ltd. 72) Inventor Shigeharu Ueda 3-5 Fujishirodai, Suita City, Osaka Prefecture A-10-108

Claims (13)

[Claims] 1. An antiviral composition comprising a thiosulfato complex salt of at least one metal selected from the group consisting of silver, copper and zinc and a thiosulfato salt supported on a porous particle carrier. 2. An antiviral composition comprising a thiosulfato silver complex salt and a thiosulfato silver salt supported on a porous particle carrier. 3. The porous particle carrier carrying the salt is at least partially coated with a coating.
Or the antiviral composition according to 2. 4. The antiviral composition according to claim 3, wherein the coating is silicon dioxide produced by hydrolysis of alkoxysilane. 5. The silver compound supported on the carrier is Cu
In the X-ray diffraction image by the Kα ray of No. 1, the diffraction line of Ag ₂ O is included, and the diffraction angle 2θ is 10.3 °, 11.2
The antiviral composition according to claim 2, characterized by having a diffraction intensity at °, 11.9 ° and 12.3 °. 6. The silver compound supported on the carrier is Cu
In the X-ray diffraction image by the Kα ray of 8., the diffraction angle 2θ is 8.
The antiviral composition according to claim 2, characterized by having a diffraction intensity at 7 °, 9.4 °, 9.8 ° and 11.2 °. 7. A step of preparing a solution of a thiosulfato complex salt of at least one metal selected from the group consisting of silver, copper and zinc and a solution of a thiosulfato salt; mixing the solution with a porous particle carrier; A method for producing an antiviral composition, which comprises a step of impregnating a carrier and a step of supporting the salt on the carrier by drying. 8. The step of preparing the solution comprises adding at least one selected from the group consisting of sulfite and hydrogensulfate to an aqueous solution of the soluble salt of the metal to the soluble salt 1.
The antiviral property according to claim 7, which comprises a step of adding 2 to 4 moles per mole and a step of adding thiosulfate to the solution in a ratio of 2 to 6 moles per 1 mole of the soluble salt. A method for producing a composition. 9. The carrier is silica gel, and the carrier carrying the salt and an alcohol solution of alkoxysilane are mixed, and water is added to the mixture to hydrolyze the alkoxysilane, whereby the surface of the carrier is oxidized. The method for producing an antiviral composition according to claim 7, which has a step of forming a silicon coating. 10. A thiosulfato complex salt or thiosulfato salt of at least one metal selected from the group consisting of silver, copper and zinc, and 1-adamantanamine hydrochloride.
A chemotherapeutic agent selected from the group consisting of thiosemicarbazide, arabinosyl nucleoside, nucleoside, 2 ', 3'-dideoxynucleoside and pyrophosphate derivative, in which at least one of the above salts is coordinated to its functional group. An antiviral composition in which a chemotherapeutic agent is supported on a porous particle carrier. 11. A silicone rubber containing the antiviral composition according to claim 1 or 10. 12. A moisture absorber comprising a hydrophilic polymer containing the antiviral composition according to any one of claims 1 to 6. 13. An ointment made of petrolatum containing the antiviral composition according to any one of claims 1 to 6 or 10.