JPH0899873A - Aerosol type foamable cleaning disinfectant for wound - Google Patents

Abstract

PURPOSE: To obtain an aerosol type cleaning disinfectant for wounds, containing a specific germicide and a specified silicone resin in a specific proportion and a propellant and capable of effectively washing away foulings and preventing the foulings from redepositing on the wounds. CONSTITUTION: This aerosol type foamable cleaning disinfectant for wounds contains (A) 0.04-0.25wt.% germicide selected from the group consisting of benzethonium chloride, benzalkonium chloride, alkyldiaminoethylglycine hydrochloride, cetylpyridinium chloride and mixtures thereof [wt.% based on the cleaning disinfectant for the wounds (except a propellant)], (B) 0.27-2.70wt.%, preferably 0.3-2.0wt.% silicone resin having <=15000cSt viscosity (at 25 deg.C) and (C) preferably 5-65wt.% (based on the weight of the whole cleaning disinfectant for the wounds) propellant such as n-butane.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an aerosol type foaming wound cleaning and disinfecting agent.

[0002]

2. Description of the Related Art Currently, various sterilizing and disinfecting sprays (one for the purpose of cleaning wounds) are on the market, but all of them have a foam that lasts for a while after spraying, It was a type that easily disappeared and drips immediately. These types of sterilizing and disinfecting sprays have the drawback of weak cleaning power. That is, considering the cleanability, it is required to mechanically clean the wound surface by foaming, quickly become liquid, and wash off the dirt, but conventional sterilization sprays have no such effect. Because it did not exist. For example, Japanese Unexamined Patent Publication No. 4-282311 discloses an aerosol type foaming wound disinfectant. However, when this disinfectant is sprayed from the aerosol container to the wound, it foams to form bubbles that cover the entire wound, but the bubbles last for a while and are defoamed by pressing with gauze or the like. . As described above, this wound disinfectant requires operations such as wiping off after being jetted to the wound.

Oxidol, which is known to mechanically clean the wound surface by foaming, quickly becomes liquid, and has the action of flushing away dirt, reacts with serum components.
It has a drawback that detergency is lowered when there is no serum component such as when there is no bleeding.

Further, mechanical cleaning by foaming is effective for cleaning and removing the mud and the like adhering to the wound, but in the case of oxidol, the performance may be lowered depending on the conditions.

[0005]

SUMMARY OF THE INVENTION An object of the present invention is to mechanically clean a wound by spraying the wound, then foaming, holding the foam for a certain period of time, and then quickly defoaming the wound.
It is to raise dirt. (EN) A wound disinfectant that quickly removes bubbles to move the dirt to the outside of the wound and prevent the dirt from reattaching to the wound.

The present inventors pay attention to the fact that oxidol mechanically cleans the wound surface by foaming and quickly becomes liquid, and has a function of draining away dirt, and sterilizing and disinfecting having such a function. He was researching sprays. Among them, particular attention was paid to the defoaming agent.

First, silicone has a drawback that it cannot be mixed with the stock solution (water). Silicone emulsions formed a suspension in transparent aerosol cans, which could cause aerosol nozzle clogging with continued use. Further, even when a thickener such as hydroxypropyl cellulose is used, the nozzle of the aerosol may be clogged due to continuous use. In addition, alcohol has a poor antifoaming action, and when it is in a large amount, it has a drawback that it becomes liable to be sprayed on a wound.

As a result of earnest studies, the present inventors have found that by first foaming, holding the foam for a certain period of time, and then quickly defoaming it by using a specific silicone resin as an antifoaming agent. It has been found that the disinfectant / sterilizing action can be imparted by improving the stain removal and making the surfactant used as the foaming agent also have the function as the sterilizing agent, and thus completed the present invention. According to the invention,
The wound disinfectant was poured onto the wound surface to form foam, and foreign substances could be washed away.

[0009]

The present invention relates to a fungicide 0.04 to 0.2 selected from the group consisting of benzethonium chloride, benzalkonium chloride, alkyldiaminoethylglycine hydrochloride, cetylpyridinium chloride and mixtures thereof.
Aerosol type foaming wound containing 5% by weight, 0.27 to 2.70% by weight of a silicone resin having a viscosity of 15,000 CS (25 ° C.) or less, preferably 0.3 to 2.0% by weight, and a propellant. It provides a cleaning and disinfecting agent.

The addition of the specific silicone resin of the present invention in the formulation of a wound disinfectant exhibited oxidol-like foaming and defoaming properties.

The silicone resin used in the present invention is 1
Those having a viscosity of 5,000 CS (25 ° C.) or less, particularly those known as SH 5500 (silicone resin manufactured by Toray Silicone Co., Ltd.) can be used. 0.27 based on the wound cleaning and disinfecting agent (excluding the propellant)
˜2.70% by weight can be blended. The preferred range is 0.3 to 2.0% by weight. When the viscosity is 15,000 CS or more, there is a problem in that it is difficult to fill the aerosol can during production. Further, if the amount used is less than 0.27% by weight, no defoaming occurs, and if it exceeds 2.70% by weight, the silicone resin adheres to the stains, and the stains become sticky and difficult to remove. The defoaming mechanism of the silicone resin is such that the surface tension of the bubbles of the gas of the propellant is lowered to cause the bubbles to burst and defoam.

The fungicide used in the present invention is selected from the group consisting of benzethonium chloride, benzalkonium chloride, cetylpyridinium chloride, alkyldiaminoethylglycine hydrochloride (known as Tego 51) and mixtures thereof. . These bactericides also act as surfactants and therefore foam. Therefore, in the present invention, the foaming agent is not an essential component. Mixing ratio is 0.04 to 0.2
It is 5% by weight, and the preferred range is 0.05 to 0.10% by weight. Alkyldiaminoethylglycine hydrochloride is
Used at 0.05 to 0.10% by weight.

Examples of components that can be added to the wound disinfectant of the present invention include a local anesthetic (dibucaine chloride), a vasoconstrictor (naphazoline hydrochloride) and an anti-inflammatory agent (chlorpheniramine maleate).

According to the invention, LPG, dimethyl ether, isopentane or n-butane can be used as propellant. Generally, a propellant is added to the undiluted solution of the wound cleaning and disinfecting agent.
~ 65 wt% can be used. If it is less than 5%, the drug remains in the aerosol can. If it exceeds 65%, the drug becomes sherbet-like at the time of injection and the cleaning effect is significantly reduced.

Next, examples of the present invention will be shown, but the invention is not limited thereto.

[0016]

EXAMPLES Examples 1 to 25 and Comparative Examples 1 to 14 An aerosol container was filled with 40 g of the stock solution of the formulation examples shown in Tables 1 to 5 and 10 g of a propellant to prepare a wound disinfectant of the present invention.

[0017]

[Table 1]

[Table 2]

[Table 3]

[Table 4]

[Table 5] In Tables 1 to 5, the stain removal test was performed by the following method.

A mixture A was prepared by mixing 5 g of mud (soil near the gate of the Kobayashi Pharmaceutical Co., Ltd. Osaka Plant (passing through a 355 μm sieve)) and 5 g of horse serum. Pig skin (4 x 4 cm
A circle with a diameter of 28 mm was drawn on the (cut into pieces) and immersed in physiological saline to swell. The pig skin was fixed on a plate, 0.5 g of the mixture A was spread evenly in a circle on the pig skin, and the aerosol of the present invention was sprayed on the pig skin from a distance of 5 cm from the pig skin. The evaluation was as follows.

〇 It drops well, △ It doesn't fall very much, × It hardly falls

[0020]

As shown in the examples of the present invention, when the wound disinfectant containing the silicone resin of the present invention is used, dirt can be effectively washed off. According to the present invention, after spraying on the wound, the wound is mechanically washed by foaming to raise the dirt, and after a certain time, the dirt is swiftly defoamed to move the dirt to the outside of the wound and the dirt wound. It is possible to prevent reattachment to In contrast, the wound disinfectant containing no silicone resin of the present invention and those outside the range of use of the various components of the present invention were inferior in the detergency of the wound.

Claims (3)

[Claims] 1. A bactericide selected from the group consisting of benzethonium chloride, benzalkonium chloride, alkyldiaminoethylglycine hydrochloride, cetylpyridinium chloride and mixtures thereof in an amount of 0.04 to 0.25% by weight (wound cleaning disinfectant ( % Excluding propellant), the same hereinafter unless otherwise specified), 0.27-2.70 wt% silicone resin having a viscosity of 15,000 CS (25 ° C) or less, and propellant Aerosol type foam wound cleaning and disinfectant containing. 2. The amount of the silicone resin compounded is 0.3 to 2.0.
The aerosol type foamable wound cleaning and disinfecting agent according to claim 1, which is in a weight%. 3. The aerosol type foaming wound cleaning / disinfecting agent according to claim 1, wherein the amount of the propellant is 5 to 65% by weight based on the total weight of the wound cleaning / disinfecting agent.