JPH05329335A - Treatment of aqueous sugar solution using reverse osmosis membrane module - Google Patents

Abstract

PURPOSE:To separate and purify a sugar solution by a method wherein reverse osmosis membrane modules are allowed to respectively communicate with the outlets of a transmitted solution tank and a concentrate tank and the transmitted solution outlets of the modules are allowed to communicate with the transmitted solution tank and the concentrate outlets of the modules are allowed to communicate with the concentrate tank and a solution to be treated is charged in both tanks. CONSTITUTION:Reverse osmosis membrane modules 2a, 2b are provided to a concentrate tank 1a and a transmitted solution tank 1b and the solution outlets of the tanks 1a, 1b are allowed to communicate with the inlets of the respective reverse osmosis membrane modules 2a,2b. The non-transmitted solution outlets of the modules 2a, 2b are allowed to communicate with the concentrate tank 1a and the transmitted solution outlets of the modules 2a, 2b are allowed to communicate with the transmitted solution tank 1b. A solution to be treated is charged in the respective tanks 1a, 1b by the almost same amount and subjected to separation treatment according to a batchwise method by driving pumps 3a, 3b. By this method the solute of a sugar solution is roughly separated into monosaccharide, oligosaccharide and polysaccharide with significant difference sufficiently near to a real rejective ratio.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION The present invention relates to a reverse osmosis membrane of an aqueous saccharide solution used for rough separation as a pretreatment when an aqueous solution of a monosaccharide, an oligosaccharide or a polysaccharide is separated and purified in the fields of food and medicine. The present invention relates to a module processing method.

[0002]

2. Description of the Prior Art In order to separate and purify monosaccharides, oligosaccharides or polysaccharides, liquid chromatography must be used because of the close proximity of molecular weight and characteristics. However, in liquid chromatography, the higher the resolution, the higher the equipment cost, the higher the operating pressure, the slower the processing speed, and the more easily product deterioration occurs. Therefore, it is advantageous to carry out a crude separation in advance and finally to carry out a liquid chromatography treatment, and it is conceivable to use a separation treatment with a reverse osmosis membrane module for this crude separation.

[0003]

[Problems to be Solved by the Invention] This reverse osmosis membrane module
In order to separate solutes by solubilization, there must be a significant difference in the inhibition rate (true inhibition rate) for the solute to be separated, but the molecular weights of monosaccharides, oligosaccharides or polysaccharides are very close. Therefore, the difference in the blocking rate is quite small.

Concentration and separation by the reverse osmosis membrane module include a batch method and a continuous method. In the batch method, the amount of treated liquid / membrane area is large and the operation is easy as compared with the continuous method. Have advantages.

However, in the case of the batch method, the amount of the solvent decreases with each cycle, and the concentration of the solute to be separated from the liquid to be treated increases in a short time with the passage of time.
The concentration polarization progresses rapidly, and the difference in the blocking rate (true blocking rate) for the solute to be separated becomes substantially zero in a short time, and the separation is performed with a certain difference in the blocking rate. It will only be in the early stages. Therefore, even if an aqueous solution of a monosaccharide, an oligosaccharide or a polysaccharide is separated by a conventional batch method by a reverse osmosis membrane module, effective rough separation cannot be performed.

An object of the present invention is to perform a sufficient separation at a blocking rate having a predominant difference sufficiently close to the true blocking rate when roughly separating a monosaccharide, an oligosaccharide or a polysaccharide using a reverse osmosis membrane module. It is an object of the present invention to provide a method for treating a saccharide solution with a reverse osmosis membrane module, which can be separated at a rate.

[0007]

A method of treating a saccharide solution with a reverse osmosis membrane module of the present invention is a method of batch-treating a saccharide solution with a reverse osmosis membrane module. The reverse osmosis membrane module is connected to the outlet of each tank, and the permeate outlet of each reverse osmosis membrane module is placed in the permeate tank, and the non-permeate outlet of each reverse osmosis membrane module is concentrated. The constitution is characterized in that the liquid to be treated is introduced into the permeate liquid tank and the concentrated liquid tank, respectively, by communicating with the liquid tank, and these liquids are processed by the batch method.
The liquid in the permeate tank can also be concentrated by a batch method using a reverse osmosis membrane module provided separately.

[0008]

[Effect] Even if the solvent permeates from the stock solution chamber to the permeation chamber in one reverse osmosis membrane module, the amount of solvent which can compensate the permeation solvent amount from the other reverse osmosis membrane module is one reverse osmosis membrane module. Since it is sent to the undiluted solution side of the osmotic membrane module, the rate of increase in the concentration of the solute to be separated becomes slow, and the superiority of the rejection rate can be well maintained over a long period of time, which leads to the true superiority of the rejection rate. Based on this, solute separation with high separation rate becomes possible.

[0009]

Embodiments of the present invention will be described below with reference to the drawings. FIG. 1 shows an example of a processing apparatus used in an embodiment of the present invention. In FIG. 1, 1a is a concentrated liquid tank, 1
b is a permeate tank. 2a and 2b are tanks 1a and 1b
The reverse osmosis membrane module (so-called loose reverse osmosis membrane module having a blocking rate for the solute to be separated between 100 and 0%) installed for each reverse osmosis membrane module. The liquid outlets of the tanks 1a and 1b communicate with the inlets of the tanks 2a and 2b, the non-permeate liquid outlets of the reverse osmosis membrane modules 2a and 2b communicate with the concentrating tank 1a, and the reverse osmosis membrane modules 2a. , 2b
The permeated liquid outlet is communicated with the permeated liquid tank 1b. 3a, 3
b is a pump.

In order to separate an aqueous solution of oligosaccharides, monosaccharides or polysaccharides according to the present invention by using this apparatus, each tank 1
Almost the same amount of the treatment liquid is introduced into a and 1b, and the treatment liquid is separated by the batch method while driving the pumps 3a and 3b.

The monosaccharides to be separated include, for example, aldoses and ketoses, and the oligosaccharides include, for example,
Sucrose, lactose, maltose, cellobiose,
There are raffinose, stachyose, glucose, mannose and the like, and examples of the polysaccharide include glucan and the like.

Further, in the ROSE reverse osmosis membrane module, N
aCL blocking rate is 10 ~ 70%, operating pressure is 0 ~ 60kg / cm ²
Stuff used.

In the method of the present invention, the amount of solvent in each tank can be kept constant, the increase in solute concentration due to the decrease in solvent amount can be eliminated, and the change in the inhibition rate due to the increase in solute concentration can be well prevented. .. Therefore, the true rejection rate for the solute to be separated can be well maintained during the treatment period without any change, and the difference in the true rejection rate can be sufficiently maintained during the entire treatment period. Compared to, high-performance separation is possible.

Actually, using the apparatus shown in FIG. 1, reverse osmosis membrane modules (NTR-7450-S2 manufactured by Nitto Denko Corporation) having a NaCL inhibition rate of 50% are provided in the respective reverse osmosis membrane modules 2a and 2b. 1 wt% for each of the concentrated liquid tank 1a and the permeated liquid tank 1b.
Aqueous solution containing raffinose and 1 wt% sucrose 1
Input 00L, pressure 10kg / cm ² , each pump 3a, 3b
Was treated for 15 minutes at a flow rate of 5 L / min and the composition of the permeate tank 1b was measured to be 0.644 wt% raffinose and 0.803 wt% sucrose, with a difference of 0.159 wt%.
%Met.

On the other hand, using the same reverse osmosis membrane module as above for the same treatment liquid as above, the conventional batch method (returning the non-permeate to the concentrate tank and accumulating the permeate to the permeate tank) is carried out. Method, the same pressure and pump flow rate as above were applied for the same time, and the composition of the permeate was measured.
0.797% by weight and 0.867% by weight,
The difference was only 0.07 wt%.

The present invention, as shown in FIG. 2, is a concentrated liquid tank 1a.
The reverse osmosis membrane module that communicates with the outlet of the above can also be implemented by using the two-stage series-connected modules 21a-22a. This example was subjected to a separation test in the same manner as in the example shown in FIG. 1 and the composition of the permeate was measured to find that it was 0.602 wt% raffinose and 0.859 wt% sucrose.

Further, as shown in FIG. 3, the present invention is carried out by using two parallel connection modules 201a-202a for the reverse osmosis membrane module communicating with the outlet of the concentrated liquid tank 1a. You can also This example was subjected to a separation test in the same manner as in the example shown in FIG. 1 and the composition of the permeate was measured to find that it was 0.608 wt% raffinose and 0.791 wt% sucrose.

Further, the reverse osmosis membrane modules communicating with the outlet of the permeate tank are arranged in multiple stages in series or in parallel.
Furthermore, a plurality of reverse osmosis membrane modules communicating with the outlet of the concentrate tank or the outlet of the permeate tank are connected in series, and a pump is installed for each reverse osmosis membrane module connected in series, and It is also possible to install a concentrate tank between the reverse osmosis membrane modules.

For example, as shown in FIG. 4, the permeated liquid tank 1a
The reverse osmosis membrane module that communicates to the outlet of the reverse osmosis membrane module via the two-stage series 21a-22a is used, and the permeate side of the reverse osmosis membrane module 21a is once communicated with the concentrated liquid tank 11a. The outlet of the concentrated liquid tank 11a can communicate with the second-stage reverse osmosis membrane module 22a via the pump 31a.

Using the apparatus shown in FIG. 4, the concentrated liquid tank 1
100 L of the above-mentioned aqueous solution is put into each of a, 11a and the permeated liquid tank 1b, and each pump 31a, 32a,
The flow rate and pressure of 3b are 5L / min and 1 respectively as in the above.
Permeate tank 1 with 0 kg / cm ² and treatment for 15 minutes as above
When the composition of the liquid b was measured, Raffinose 0.61
The amount was 0 wt% and the scroll was 0.832 wt%.

In the present invention, the liquid in the permeate tank can be concentrated by a batch method using a reverse osmosis membrane module provided separately. For example, as shown in FIG. 5, a reverse osmosis membrane module 2c for batch concentration can be separately installed in the permeate tank 1b in the apparatus shown in FIG. in this case,
The decrease of the solvent by the batch method can be sufficiently compensated by the solvent constantly sent to the permeate tank 1b, so that the separation performance can be well maintained and the concentration can be performed. Actually, a reverse osmosis membrane module 2c for concentration is a reverse osmosis membrane module (NTR-7450-S2 manufactured by Nitto Denko Corporation) with a NaCL inhibition rate of 50%. A flow rate of the pump 3c was set to 5 L / min, and a separation test was performed in the same manner as in the embodiment of FIG.
When the composition of the liquid in the permeated liquid tank 1b was measured, Raffino-
The amounts were 0.935 wt% and 1.13 wt%, respectively.

[0022]

As described above, according to the method for treating a saccharide solution with a reverse osmosis membrane module of the present invention, an oligosaccharide, a monosaccharide or a polysaccharide can be separated with an excellent separation rate as compared with the conventional batch method. , Which is useful as a pretreatment by liquid chromatography and can reduce the separation cost of the final purification by liquid chromatography. Further, since the treatment time by liquid chromatography can be shortened and the exposure time to high pressure can be shortened, product deterioration can be well prevented.

[Brief description of drawings]

FIG. 1 is an explanatory diagram showing an example of a processing device used in the present invention.

FIG. 2 is an explanatory diagram showing another example of the processing apparatus used in the present invention.

FIG. 3 is an explanatory diagram showing another example of the processing apparatus used in the present invention.

FIG. 4 is an explanatory diagram showing another example of the processing apparatus used in the present invention.

FIG. 5 is an explanatory diagram showing another example of the processing apparatus used in the present invention.

[Explanation of symbols]

 1a Concentrated liquid tank 1b Permeated liquid tank 2a Reverse osmosis membrane module 21a Reverse osmosis membrane module 22a Reverse osmosis membrane module 201a Reverse osmosis membrane module 202a Reverse osmosis membrane module 2b Reverse osmosis membrane module 2a Reverse Osmosis Membrane Module 21b Reverse Osmosis Membrane Module 22b Reverse Osmosis Membrane Module 2c Reverse Osmosis Membrane Module

Claims (2)

[Claims] 1. A method of batch treating an aqueous saccharide solution with a reverse osmosis membrane module, wherein a permeate tank and a concentrate tank are respectively provided, and the reverse osmosis membrane module is provided at the outlet of each tank.
The reverse osmosis membrane module, the permeate outlet of each reverse osmosis membrane module to the permeate tank, and the non-permeate outlet of each reverse osmosis membrane module to the concentrate tank. A method for treating an aqueous saccharide solution by a reverse osmosis membrane module, which comprises pouring a liquid to be treated into each of the above and treating these liquids by a batch method. 2. The method for treating an aqueous saccharide solution with a reverse osmosis membrane module according to claim 1, wherein the liquid in the permeate tank is concentrated by a batch method with a reverse osmosis membrane module provided separately.