JP6966667B2 - ジクアホソルまたはその塩、およびポリビニルピロリドンを含有する水性眼科用組成物 - Google Patents

ジクアホソルまたはその塩、およびポリビニルピロリドンを含有する水性眼科用組成物 Download PDF

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Publication number: JP6966667B2
Authority: JP; Japan
Prior art keywords: aqueous ophthalmic; ophthalmic composition; diquafosol; polyvinylpyrrolidone; eye
Prior art date: 2019-08-27
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Active

Application number

JP2021521065A

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English (en)

Japanese (ja)

Other versions

JPWO2021039748A1 (ja

Inventor

健司森島

博之浅田

雄介桃川

明日香神村

健一遠藤

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Santen Pharmaceutical Co Ltd

Original Assignee

Santen Pharmaceutical Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2019-08-27

Filing date

2020-08-25

Publication date

2021-11-17

2020-08-25 Application filed by Santen Pharmaceutical Co Ltd filed Critical Santen Pharmaceutical Co Ltd

2021-09-30 Publication of JPWO2021039748A1 publication Critical patent/JPWO2021039748A1/ja

2021-10-20 Priority to JP2021171358A priority Critical patent/JP7614069B2/ja

2021-11-17 Application granted granted Critical

2021-11-17 Publication of JP6966667B2 publication Critical patent/JP6966667B2/ja

2024-12-25 Priority to JP2024228577A priority patent/JP2025031918A/ja

Status Active legal-status Critical Current

2040-08-25 Anticipated expiration legal-status Critical

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239000000203 mixture Substances 0.000 title claims description 266
229950003529 diquafosol Drugs 0.000 title claims description 153
229920000036 polyvinylpyrrolidone Polymers 0.000 title claims description 107
235000013855 polyvinylpyrrolidone Nutrition 0.000 title claims description 107
239000001267 polyvinylpyrrolidone Substances 0.000 title claims description 95
NMLMACJWHPHKGR-NCOIDOBVSA-N P(1),P(4)-bis(uridin-5'-yl) tetraphosphate Chemical compound N1([C@@H]2O[C@@H]([C@H]([C@H]2O)O)COP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(=O)OC[C@@H]2[C@H]([C@H]([C@@H](O2)N2C(NC(=O)C=C2)=O)O)O)C=CC(=O)NC1=O NMLMACJWHPHKGR-NCOIDOBVSA-N 0.000 title claims description 78
150000003839 salts Chemical class 0.000 title claims description 47
239000003889 eye drop Substances 0.000 claims description 229
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SQGYOTSLMSWVJD-UHFFFAOYSA-N silver(1+) nitrate Chemical compound [Ag+].[O-]N(=O)=O SQGYOTSLMSWVJD-UHFFFAOYSA-N 0.000 claims description 60
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OWTGMPPCCUSXIP-FNXFGIETSA-J tetrasodium;[[(2r,3s,4r,5r)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-oxidophosphoryl] [[[(2r,3s,4r,5r)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-oxidophosphoryl]oxy-oxidophosphoryl] phosphate Chemical compound [Na+].[Na+].[Na+].[Na+].N1([C@@H]2O[C@@H]([C@H]([C@H]2O)O)COP([O-])(=O)OP([O-])(=O)OP([O-])(=O)OP([O-])(=O)OC[C@@H]2[C@H]([C@H]([C@@H](O2)N2C(NC(=O)C=C2)=O)O)O)C=CC(=O)NC1=O OWTGMPPCCUSXIP-FNXFGIETSA-J 0.000 description 92
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7084—Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
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- A—HUMAN NECESSITIES
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
- A—HUMAN NECESSITIES
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
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JP2021521065A 2019-08-27 2020-08-25 ジクアホソルまたはその塩、およびポリビニルピロリドンを含有する水性眼科用組成物 Active JP6966667B2 (ja)

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JP2022003099A (ja)	2022-01-11
CN114286670B (zh)	2024-01-16
JPWO2021039748A1 (ja)	2021-09-30
PH12022550474A1 (en)	2023-03-06
TWI848171B (zh)	2024-07-11
KR20220052971A (ko)	2022-04-28
TW202122094A (zh)	2021-06-16
WO2021039748A1 (ja)	2021-03-04
CN114286670A (zh)	2022-04-05
CN117771172A (zh)	2024-03-29
KR20240049646A (ko)	2024-04-16
JP2025031918A (ja)	2025-03-07
JP7614069B2 (ja)	2025-01-15
KR102656181B1 (ko)	2024-04-08

Publication	Publication Date	Title
JP7472202B2 (ja)	2024-04-22	ジクアホソルおよびカチオン性ポリマーを含有する眼科用組成物
JP7614069B2 (ja)	2025-01-15	ジクアホソルまたはその塩、およびポリビニルピロリドンを含有する水性眼科用組成物
JP7526718B2 (ja)	2024-08-01	ジクアホソルまたはその塩、ビニル系高分子およびセルロース系高分子を含有する眼科用組成物
JP2025096568A (ja)	2025-06-26	ソフトコンタクトレンズが装用されたドライアイ患者の眼に点眼されるように用いられることを特徴とするドライアイ治療剤
CN110913867B (zh)	2021-06-11	热凝胶化人工泪液
HK40065412A (zh)	2022-07-22	含有地夸磷索或其盐、及聚乙烯吡咯烷酮的水性眼科用组合物
HK40037570A (zh)	2021-06-11	含有地夸磷索及阳离子性聚合物的眼科用组合物

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