JP6775976B2 - Topical preparation for reducing skin friction - Google Patents
Topical preparation for reducing skin friction Download PDFInfo
- Publication number
- JP6775976B2 JP6775976B2 JP2016056178A JP2016056178A JP6775976B2 JP 6775976 B2 JP6775976 B2 JP 6775976B2 JP 2016056178 A JP2016056178 A JP 2016056178A JP 2016056178 A JP2016056178 A JP 2016056178A JP 6775976 B2 JP6775976 B2 JP 6775976B2
- Authority
- JP
- Japan
- Prior art keywords
- friction
- external preparation
- skin
- tocopherol
- reducing skin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
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- 230000001603 reducing effect Effects 0.000 title claims description 95
- 238000002360 preparation method Methods 0.000 title claims description 85
- 230000000699 topical effect Effects 0.000 title 1
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- 125000004432 carbon atom Chemical group C* 0.000 claims description 40
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- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims description 27
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- MPDGHEJMBKOTSU-YKLVYJNSSA-N 18beta-glycyrrhetic acid Chemical compound C([C@H]1C2=CC(=O)[C@H]34)[C@@](C)(C(O)=O)CC[C@]1(C)CC[C@@]2(C)[C@]4(C)CC[C@@H]1[C@]3(C)CC[C@H](O)C1(C)C MPDGHEJMBKOTSU-YKLVYJNSSA-N 0.000 claims description 18
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- KSCKTBJJRVPGKM-UHFFFAOYSA-N octan-1-olate;titanium(4+) Chemical compound [Ti+4].CCCCCCCC[O-].CCCCCCCC[O-].CCCCCCCC[O-].CCCCCCCC[O-] KSCKTBJJRVPGKM-UHFFFAOYSA-N 0.000 description 1
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- VMYFZRTXGLUXMZ-UHFFFAOYSA-N triethyl citrate Natural products CCOC(=O)C(O)(C(=O)OCC)C(=O)OCC VMYFZRTXGLUXMZ-UHFFFAOYSA-N 0.000 description 1
- 235000013769 triethyl citrate Nutrition 0.000 description 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
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- NCYCYZXNIZJOKI-UHFFFAOYSA-N vitamin A aldehyde Natural products O=CC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C NCYCYZXNIZJOKI-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Description
本発明は、皮膚摩擦軽減用外用製剤に関する。より具体的には、本発明は、皮膚に皮膜を形成させることにより、皮膚への摩擦を軽減できる皮膚摩擦軽減用外用製剤に関する。 The present invention relates to an external preparation for reducing skin friction. More specifically, the present invention relates to an external preparation for reducing skin friction, which can reduce friction on the skin by forming a film on the skin.
日常生活において、皮膚は外界物との摩擦による刺激を受けている。このような皮膚に対する刺激は、不快感を生じさせるだけでなく、皮膚に様々な症状を引き起こすことがある。例えば、皮膚に対する摩擦に起因する症状としては、下着のしめつけによって生じるかぶれ、床ずれや靴ずれ等の症状がある。また、指輪等のアクセサリーを装着した際に、指との間の摩擦により脱着し難いことがある。そこで、従来、皮膚に付加される摩擦による不具合に対する対処手法が種々提案されている。 In daily life, the skin is stimulated by friction with external objects. Such irritation to the skin not only causes discomfort, but can also cause various symptoms on the skin. For example, as a symptom caused by friction against the skin, there are a symptom such as a rash caused by tightening underwear, a bed sore, and a shoe slip. In addition, when an accessory such as a ring is attached, it may be difficult to attach or detach due to friction with the finger. Therefore, various methods for dealing with problems caused by friction applied to the skin have been conventionally proposed.
例えば、特許文献1には、踵当接部内面に摩擦付与体を取り付けたフットカバー(変形靴下)を使用することによって、靴擦れを防止できることが開示されている。しかしながら、特許文献1のような身体装着具では、摩擦による物理的刺激を受ける箇所以外の皮膚部位も覆われてしまうため、使用感が悪く、また当該身体装着具を装着した部位が嵩張るという欠点がある。 For example, Patent Document 1 discloses that shoe rubbing can be prevented by using a foot cover (deformed sock) having a friction imparting body attached to the inner surface of the heel contact portion. However, a body-wearing device such as Patent Document 1 has a drawback that the skin part other than the part that receives physical stimulation due to friction is covered, so that the feeling of use is poor and the part on which the body-wearing tool is worn is bulky. There is.
また、例えば、特許文献2には、シート体の一方の面に形成された粘着剤層面に短冊状テープ片が適宜間隔をもって複数平行に貼着固定されているシールを、靴擦れが生じた皮膚部位に貼付することによって、靴擦れの防止が図られることが報告されている。しかしながら、特許文献2のようなシート状のものでは、柔軟性がなく、関節等の可動域には適用し難いことに加え、貼付時に突っ張り感(皮膚が引っ張られる感じ)があり、使用感が悪いという欠点がある。 Further, for example, in Patent Document 2, a seal in which a plurality of strip-shaped tape pieces are stuck and fixed in parallel on an adhesive layer surface formed on one surface of a sheet body at appropriate intervals is provided on a skin portion where shoe rubbing has occurred. It has been reported that by attaching it to the paper, it is possible to prevent the shoes from rubbing. However, a sheet-like material such as Patent Document 2 is inflexible and difficult to apply to a range of motion such as joints, and also has a feeling of tension (feeling that the skin is pulled) at the time of application, which gives a feeling of use. It has the drawback of being bad.
一方、従来、皮膚上に皮膜を直接形成することによって、皮膚摩擦を軽減させる技術については知られていない。 On the other hand, conventionally, a technique for reducing skin friction by directly forming a film on the skin has not been known.
本発明の目的は、皮膚への摩擦を軽減できる皮膚摩擦軽減用外用製剤を提供することである。 An object of the present invention is to provide an external preparation for reducing skin friction that can reduce friction on the skin.
本発明者は、前記課題を解決すべく鋭意検討を行ったところ、皮膚上に直接皮膜を形成することによって、皮膚摩擦を軽減させるという新たな着想に至った。そして、皮膚上に直接皮膜を形成する外用製剤について鋭意検討を行ったところ、炭素数1〜4の一価アルコール及びベンジルアルコールよりなる群から選択される少なくとも1種のアルコールと、炭素数2〜4のモノカルボン酸と炭素数1〜5の一価アルコールとのエステルと、ニトロセルロースとを含む外用製剤は、皮膚上で摩擦軽減作用が高い皮膜を形成でき、皮膚摩擦軽減用外用製剤として有用であることを見出した。また、本発明者は、当該外用製剤に、更にパンテノール類等の特定の成分を含有させることにより、使用時の突っ張り感を低減でき、使用感が向上することをも見出した。本発明は、これらの知見に基づいて更に検討を重ねることにより完成したものである。 As a result of diligent studies to solve the above problems, the present inventor has come up with a new idea of reducing skin friction by forming a film directly on the skin. Then, as a result of diligent studies on an external preparation that forms a film directly on the skin, at least one alcohol selected from the group consisting of monohydric alcohols having 1 to 4 carbon atoms and benzyl alcohol, and 2 to 2 carbon atoms. An external preparation containing an ester of a monocarboxylic acid of 4 and a monohydric alcohol having 1 to 5 carbon atoms and nitrocellulose can form a film having a high friction reducing effect on the skin, and is useful as an external preparation for reducing skin friction. I found that. The present inventor has also found that by further adding a specific component such as panthenol to the external preparation, the feeling of tension during use can be reduced and the feeling of use is improved. The present invention has been completed by further studies based on these findings.
即ち、本発明は、下記に掲げる態様の発明を提供する。
項1. (A)炭素数1〜4の一価アルコール及びベンジルアルコールよりなる群から選択される少なくとも1種のアルコール、(B)炭素数2〜4のモノカルボン酸と炭素数1〜5の一価アルコールとのエステル、並びに(C)ニトロセルロースを含有することを特徴とする、皮膚摩擦軽減用外用製剤。
項2. 前記(A)成分が、エタノール、イソプロパノール、及びベンジルアルコールよりなる群から選択される少なくとも1種であり、且つ前記(B)成分が、酢酸エチル及び酢酸ブチルよりなる群から選択される少なくとも1種である、項1に記載の皮膚摩擦軽減用外用製剤。
項3. 更に、(D)グリチルリチン酸類、トコフェロール類、パンテノール類、ビタミンC類、ビタミンA類、ピリドキシン類、アラントイン類、及びアズレン類よりなる群から選択される少なくとも1種を含む、項1又は2に記載の皮膚摩擦軽減用外用製剤。
項4. 靴擦れ予防用である、項1〜3のいずれかに記載の皮膚摩擦軽減用外用製剤。
That is, the present invention provides the inventions of the following aspects.
Item 1. (A) At least one alcohol selected from the group consisting of monohydric alcohols having 1 to 4 carbon atoms and benzyl alcohol, (B) monocarboxylic acids having 2 to 4 carbon atoms and monohydric alcohols having 1 to 5 carbon atoms. An external preparation for reducing skin friction, which comprises an ester of (C) and (C) nitrocellulose.
Item 2. The component (A) is at least one selected from the group consisting of ethanol, isopropanol, and benzyl alcohol, and the component (B) is at least one selected from the group consisting of ethyl acetate and butyl acetate. Item 2. The external preparation for reducing skin friction according to Item 1.
Item 3. Further, item 1 or 2 includes (D) at least one selected from the group consisting of glycyrrhizic acids, tocopherols, panthenol, vitamin C, vitamin A, pyridoxines, allantoins, and azulene. The above-mentioned external preparation for reducing skin friction.
Item 4. Item 8. The external preparation for reducing skin friction according to any one of Items 1 to 3, which is for preventing shoe rubbing.
本発明の皮膚摩擦軽減用外用製剤は、皮膚上に摩擦軽減作用が高い皮膜を形成することにより、皮膚に付加される摩擦による不具合を抑制することが可能になる。 The external preparation for reducing skin friction of the present invention can suppress defects due to friction applied to the skin by forming a film having a high friction reducing effect on the skin.
更に、本発明の皮膚摩擦軽減用外用製剤の好適な一態様では、使用時の突っ張り感(皮膜を皮膚上に形成させた際に皮膚が引っ張られる感じ)を抑制できるので、関節等の可動域に適用しても、関節等の可動域や足部に適用しても身体の動きに追従でき、破れたり、剥がれたりするのを抑制して、良好な使用感を与えることができる。 Further, in a preferred embodiment of the external preparation for reducing skin friction of the present invention, a feeling of tension during use (a feeling of pulling the skin when a film is formed on the skin) can be suppressed, so that the range of motion of joints and the like can be suppressed. Even if it is applied to the range of motion of joints or the like or the foot, it can follow the movement of the body, suppress tearing or peeling, and give a good feeling of use.
本発明の皮膚摩擦軽減用外用製剤は、炭素数1〜4の一価アルコール及びベンジルアルコールよりなる群から選択される少なくとも1種のアルコール(以下、(A)成分と表記することもある)と、炭素数2〜4のモノカルボン酸と炭素数1〜5の一価アルコールとのエステル(以下、(B)成分と表記することもある)と、ニトロセルロース(以下、(C)成分と表記することもある)を含有することを特徴とする。以下、本発明の皮膚摩擦軽減用外用製剤について詳述する。 The external preparation for reducing skin friction of the present invention contains at least one alcohol selected from the group consisting of monohydric alcohols having 1 to 4 carbon atoms and benzyl alcohol (hereinafter, may be referred to as component (A)). , An ester of a monocarboxylic acid having 2 to 4 carbon atoms and a monohydric alcohol having 1 to 5 carbon atoms (hereinafter, may be referred to as a component (B)) and nitrocellulose (hereinafter, referred to as a component (C)). It is characterized by containing (may be). Hereinafter, the external preparation for reducing skin friction of the present invention will be described in detail.
(A)炭素数1〜4の一価アルコール及び/又はベンジルアルコール
本発明の皮膚摩擦軽減用外用製剤は、炭素数1〜4の一価アルコール及びベンジルアルコールよりなる群から選択される少なくとも1種のアルコールを含有する。
(A) Monohydric alcohol having 1 to 4 carbon atoms and / or benzyl alcohol The external preparation for reducing skin friction of the present invention is at least one selected from the group consisting of monohydric alcohol having 1 to 4 carbon atoms and benzyl alcohol. Contains alcohol.
炭素数1〜4の一価アルコールの種類については、特に制限されないが、例えば、メタノール、エタノール、n−プロパノール、イソプロパノール、n−ブタノール、sec−ブタノール、イソブタノール、tert-ブタノールが挙げられる。 The type of monohydric alcohol having 1 to 4 carbon atoms is not particularly limited, and examples thereof include methanol, ethanol, n-propanol, isopropanol, n-butanol, sec-butanol, isobutanol, and tert-butanol.
これらのアルコールの中でも、好ましくは炭素数2〜4の一価アルコール及びベンジルアルコール、更に好ましくはエタノール、イソプロパノール、n−ブタノール、及びベンジルアルコール、特に好ましくはエタノール、イソプロパノール、及びベンジルアルコールが挙げられる。 Among these alcohols, monohydric alcohols and benzyl alcohols having 2 to 4 carbon atoms are preferable, ethanol, isopropanol, n-butanol and benzyl alcohol are more preferable, and ethanol, isopropanol and benzyl alcohol are particularly preferable.
本発明の皮膚摩擦軽減用外用製剤において、(A)成分として、炭素数1〜4の一価アルコール及びベンジルアルコールの中から、1種を単独で使用してもよく、また2種以上を組み合わせて使用してもよい。 In the external preparation for reducing skin friction of the present invention, as the component (A), one of monohydric alcohols having 1 to 4 carbon atoms and benzyl alcohol may be used alone, or two or more thereof may be combined. May be used.
より一層優れた摩擦軽減作用を有する皮膜を皮膚上に形成させるという観点から、(A)成分の好適な態様として、炭素数1〜4の一価アルコール、又は炭素数1〜4の一価アルコールとベンジルアルコールの組み合わせ;更に好ましくは、エタノール及びイソプロパノールの少なくとも1種、又はエタノール及びイソプロパノールの少なくとも1種とベンジルアルコールの組み合わせ;特に好ましくは、イソプロパノールとベンジルアルコールの組み合わせが挙げられる。特に、(A)成分として、炭素数1〜4の一価アルコールとベンジルアルコールを組み合わせて使用する場合には、より一層優れた摩擦軽減作用を有する皮膜を皮膚上に形成できると共に、水との接触による皮膜の白濁化やゲル化を抑制でき、良好な性状を備えさせることも可能になる From the viewpoint of forming a film having an even more excellent friction reducing action on the skin, a preferred embodiment of the component (A) is a monohydric alcohol having 1 to 4 carbon atoms or a monohydric alcohol having 1 to 4 carbon atoms. And benzyl alcohol; more preferably at least one of ethanol and isopropanol, or at least one of ethanol and isopropanol and benzyl alcohol; particularly preferably a combination of isopropanol and benzyl alcohol. In particular, when a monohydric alcohol having 1 to 4 carbon atoms and a benzyl alcohol are used in combination as the component (A), a film having an even more excellent friction reducing effect can be formed on the skin and with water. It is possible to suppress whitening and gelation of the film due to contact, and it is also possible to have good properties.
(A)成分として、炭素数1〜4の一価アルコールとベンジルアルコールを組み合わせて使用する場合、これらの比率については、特に制限されないが、例えば、炭素数1〜4の一価アルコール1重量部当たり、ベンジルアルコールが0.05〜2重量部、好ましくは0.05〜1.25重量部、より好ましくは0.05〜0.77重量部、更に好ましくは0.06〜0.56重量部が挙げられる。 When a monovalent alcohol having 1 to 4 carbon atoms and a benzyl alcohol are used in combination as the component (A), the ratio thereof is not particularly limited, but for example, 1 part by weight of the monovalent alcohol having 1 to 4 carbon atoms is used. Benzyl alcohol is 0.05 to 2 parts by weight, preferably 0.05 to 1.25 parts by weight, more preferably 0.05 to 0.77 parts by weight, still more preferably 0.06 to 0.56 parts by weight. Can be mentioned.
本発明の皮膚摩擦軽減用外用製剤において、(A)成分の含有量については、特に制限されないが、例えば、10〜70重量%、好ましくは15〜65重量%、更に好ましくは18〜60重量%、特に好ましくは25〜60重量%が挙げられる。(A)成分が前記含有量を満たすことによって、より一層優れた摩擦軽減作用を有する皮膜を皮膚上に形成させることが可能になる。更に、(A)成分が前記含有量を満たしつつ、後述する(D)成分を含む場合には、使用時の突っ張り感をより一層効果的に低減することも可能なる。 The content of the component (A) in the external preparation for reducing skin friction of the present invention is not particularly limited, but is, for example, 10 to 70% by weight, preferably 15 to 65% by weight, and more preferably 18 to 60% by weight. , Especially preferably 25 to 60% by weight. When the component (A) satisfies the above content, it becomes possible to form a film having an even more excellent friction reducing action on the skin. Further, when the component (A) satisfies the content and also contains the component (D) described later, it is possible to more effectively reduce the feeling of tension during use.
(B)炭素数2〜4のモノカルボン酸と炭素数1〜5の一価アルコールとのエステル
本発明の皮膚摩擦軽減用外用製剤は、炭素数2〜4のモノカルボン酸と炭素数1〜5の一価アルコールとのエステルを含有する。「炭素数2〜4のモノカルボン酸と炭素数1〜5の一価アルコールとのエステル」とは、炭素数2〜4のモノカルボン酸1分子と炭素数1〜5の一価アルコール1分子がエステル結合した化合物である。
(B) Ester of a monocarboxylic acid having 2 to 4 carbon atoms and a monohydric alcohol having 1 to 5 carbon atoms The external preparation for reducing skin friction of the present invention contains a monocarboxylic acid having 2 to 4 carbon atoms and 1 to 5 carbon atoms. Contains an ester of 5 monohydric alcohol. "Ester of a monocarboxylic acid having 2 to 4 carbon atoms and a monohydric alcohol having 1 to 5 carbon atoms" means one molecule of monocarboxylic acid having 2 to 4 carbon atoms and one molecule of monohydric alcohol having 1 to 5 carbon atoms. Is an ester-bonded compound.
前記エステルを構成する炭素数2〜4のモノカルボン酸の種類については、特に制限されないが、例えば、酢酸、乳酸、プロピオン酸、酪酸等が挙げられる。これらのモノカルボン酸の中でも、好ましくは、炭素数2又は3のモノカルボン酸、更に好ましくは、酢酸、乳酸が挙げられる。 The type of monocarboxylic acid having 2 to 4 carbon atoms constituting the ester is not particularly limited, and examples thereof include acetic acid, lactic acid, propionic acid, butyric acid and the like. Among these monocarboxylic acids, a monocarboxylic acid having 2 or 3 carbon atoms is preferable, and acetic acid and lactic acid are more preferable.
また、前記エステルを構成する炭素数1〜5の一価アルコールの種類については、特に制限されないが、例えば、メタノール、エタノール、n−プロパノール、イソプロパノール、n−ブタノール、sec−ブタノール、イソブタノール、tert-ブタノール、ベンジルアルコール、1−ペンタノール、3−メチル−1−ブタノール、2−メチル−1−ブタノール、2,2ジメチル−1−プロパノール、2−ペンタノール、3−メチル−2−ブタノール、3−ペンタノール、2−メチル−2−ブタノールが挙げられる。これらのアルコールの中でも、好ましくは、メタノール、エタノール、n−プロパノール、イソプロパノール、n−ブタノール、1−ペンタノール、ベンジルアルコール、更に好ましくはエタノール、n−プロパノール、イソプロパノール、n−ブタノール、1−ペンタノールが挙げられる。 The type of monohydric alcohol having 1 to 5 carbon atoms constituting the ester is not particularly limited, but for example, methanol, ethanol, n-propanol, isopropanol, n-butanol, sec-butanol, isobutanol, tert. -Butanol, benzyl alcohol, 1-pentanol, 3-methyl-1-butanol, 2-methyl-1-butanol, 2,2dimethyl-1-propanol, 2-pentanol, 3-methyl-2-butanol, 3 -Pentanol and 2-methyl-2-butanol can be mentioned. Among these alcohols, preferred are methanol, ethanol, n-propanol, isopropanol, n-butanol, 1-pentanol, benzyl alcohol, and more preferably ethanol, n-propanol, isopropanol, n-butanol, 1-pentanol. Can be mentioned.
前記エステルとして、具体的には、酢酸メチル、酢酸エチル、酢酸プロピル(酢酸n−プロピル)、酢酸イソプロピル、酢酸ブチル(酢酸n−ブチル)、酢酸sec−ブチル、酢酸イソブチル、酢酸ペンチル(酢酸1−ペンチル)、乳酸エチル、乳酸ブチル、酢酸イソアミル(酢酸3−メチルブチル)、酪酸エチル、プロピオン酸エチル等が挙げられる。これらの中でも、より一層優れた摩擦軽減作用を有する皮膜を皮膚上に形成させるという観点から、前記エステルとして、好ましくは、酢酸エチル、酢酸ブチル、乳酸エチル;更に好ましくは、酢酸エチル、酢酸ブチルが挙げられる。 Specific examples of the ester include methyl acetate, ethyl acetate, propyl acetate (n-propyl acetate), isopropyl acetate, butyl acetate (n-butyl acetate), sec-butyl acetate, isobutyl acetate, and pentyl acetate (1-propyl acetate). Pentyl), ethyl lactate, butyl lactate, isoamyl acetate (3-methylbutyl acetate), ethyl butyrate, ethyl propionate and the like. Among these, ethyl acetate, butyl acetate, ethyl lactate are preferable, and ethyl acetate and butyl acetate are more preferable, as the ester from the viewpoint of forming a film having an even more excellent friction reducing action on the skin. Can be mentioned.
本発明の皮膚摩擦軽減用外用製剤において、(B)成分として、前記エステルの中から、1種を単独で使用してもよく、また2種以上を組み合わせて使用してもよい。例えば、(B)成分として、沸点が異なる2種以上のエステルを組み合わせて使用することにより、本発明の皮膚摩擦軽減用外用製剤の皮膜形成速度を適宜調節することもできる。例えば、沸点が100℃未満の上記エステル(例えば、酢酸エチル)と、沸点が100℃以上の上記エステル(例えば、酢酸ブチル)を併用し、沸点が100℃未満の上記エステルの比率を高く設定すると、皮膜形成速度を早くすることができ、沸点が100℃未満の上記エステルの比率を低く設定すると、皮膜形成速度を遅くすることができる。 In the external preparation for reducing skin friction of the present invention, as the component (B), one of the esters may be used alone, or two or more thereof may be used in combination. For example, by using two or more kinds of esters having different boiling points in combination as the component (B), the film formation rate of the external preparation for reducing skin friction of the present invention can be appropriately adjusted. For example, when the above ester having a boiling point of less than 100 ° C. (for example, ethyl acetate) and the above ester having a boiling point of 100 ° C. or higher (for example, butyl acetate) are used in combination, the ratio of the above ester having a boiling point of less than 100 ° C. is set high. The film formation rate can be increased, and if the ratio of the ester having a boiling point of less than 100 ° C. is set low, the film formation rate can be decreased.
(B)成分の好適な例として、酢酸エチルと酢酸ブチルを組み合わせて使用し、酢酸エチル1重量部当たり、酢酸ブチルを0.05〜0.5重量部、好ましくは0.07〜0.4重量部、更に好ましくは0.1〜0.3重量部となる比率を充足させることが挙げられる。このような比率で酢酸エチルと酢酸ブチルを併用することにより、皮膚に塗布した際に適度な皮膜形成速度で、皮膜を形成させることが可能になる。 As a preferable example of the component (B), ethyl acetate and butyl acetate are used in combination, and 0.05 to 0.5 parts by weight of butyl acetate, preferably 0.07 to 0.4 parts by weight, is used per 1 part by weight of ethyl acetate. It is possible to satisfy a ratio of parts by weight, more preferably 0.1 to 0.3 parts by weight. By using ethyl acetate and butyl acetate in combination at such a ratio, it becomes possible to form a film at an appropriate film forming rate when applied to the skin.
本発明の皮膚摩擦軽減用外用製剤において、(B)成分の含有量については、特に制限されず、(B)成分の種類や備えさせるべき皮膜形成速度等に応じて適宜設定すればよいが、例えば、該製剤の総量当たり、25〜65重量%、好ましくは25〜60重量%、更に好ましくは35〜55重量%が挙げられる。 In the external preparation for reducing skin friction of the present invention, the content of the component (B) is not particularly limited and may be appropriately set according to the type of the component (B), the film forming speed to be provided, and the like. For example, 25 to 65% by weight, preferably 25 to 60% by weight, more preferably 35 to 55% by weight, based on the total amount of the preparation.
本発明の皮膚摩擦軽減用外用製剤において、(A)成分に対する(B)成分の比率については、これらの両成分の各含有量を充足する範囲で適宜設定すればよいが、例えば、(A)成分1重量部当たり、(B)成分が0.2〜10重量部となる比率が挙げられる。 In the external preparation for reducing skin friction of the present invention, the ratio of the component (B) to the component (A) may be appropriately set within a range that satisfies each content of both of these components. For example, (A) The ratio of the component (B) to 0.2 to 10 parts by weight per part by weight of the component can be mentioned.
(A)成分に対する(B)成分の比率として、より一層優れた摩擦軽減作用を有する皮膜を皮膚上に形成させるという観点から、(A)成分1重量部当たり、(B)成分が好ましくは0.4〜6重量部、更に好ましくは0.4〜5重量部、特に好ましくは0.4〜3.5重量部、より一層好ましくは0.6〜1.8重量部となる比率が挙げられる。このような比率を充足する場合には、より一層優れた摩擦軽減作用を有する皮膜を皮膚上に形成できることに加え、水との接触による皮膜の白濁化やゲル化を抑制でき、良好な性状を備えさせることも可能になる。更に、このような比率を充足しつつ、後述する(D)成分を含む場合には、突っ張り感をより一層効果的に低減することも可能なる。 As a ratio of the component (B) to the component (A), the component (B) is preferably 0 per part by weight of the component (A) from the viewpoint of forming a film having an even more excellent friction reducing effect on the skin. The ratio is .4 to 6 parts by weight, more preferably 0.4 to 5 parts by weight, particularly preferably 0.4 to 3.5 parts by weight, and even more preferably 0.6 to 1.8 parts by weight. .. When such a ratio is satisfied, in addition to being able to form a film having an even better friction-reducing effect on the skin, it is possible to suppress whitening and gelation of the film due to contact with water, resulting in good properties. It will also be possible to prepare. Further, when the component (D) described later is contained while satisfying such a ratio, it is possible to further effectively reduce the feeling of tension.
(C)ニトロセルロース
本発明の皮膚摩擦軽減用外用製剤は、ニトロセルロースを含有する。ニトロセルロースは、皮膚上形成される皮膜の基剤としての役割を果たす。
(C) Nitrocellulose The external preparation for reducing skin friction of the present invention contains nitrocellulose. Nitrocellulose serves as a base for the film formed on the skin.
本発明に使用されるニトロセルロースは、皮膚上で皮膜を形成できる限り、その分子量、窒素含有量等については、特に制限されない。 The nitrocellulose used in the present invention is not particularly limited in its molecular weight, nitrogen content and the like as long as it can form a film on the skin.
また、本発明の皮膚摩擦軽減用外用製剤では、ニトロセルロースとして、ピロキシリンを使用することもできる。ピロキシリンとは、ニトロセルロースが溶媒に潤されているものであり、具体的には、ニトロセルロース70重量%程度とイソプロパノール30重量%程度の混合物が挙げられる。本発明において、(C)成分として、市販されているピロキシリンを使用することもできる。市販されているピロキシリンとしては、具体的には、T.N.C.Industrial Co.,Ltd製のRS 1/32 sec、RS 1/16 sec、RS 1/8 sec、RS 1/8 L sec、RS 1/8 H sec、RS 1/4 sec、RS 1/4 H sec、RS 1/2 sec、RS 1 sec、RS 5〜6 sec、RS 10〜15 sec、RS 15〜20 sec、RS 30〜40 sec、RS 60〜80 sec、RS 120 sec、RS 150 sec、RS 300 sec、RS 500 sec、RS 800 sec、RS 1200 sec、RS 2000 sec;Korea CNC Ltd製のRS 1/16、RS 1/8、RS 1/4、RS 1/2、RS 1、RS 2、RS 5、RS 7、RS 20、RS 60、RS 120、RS 500、RS 1000、RS 2000等が挙げられる。これらは、1種単独で使用してもよく、2種以上を組み合わせて使用してもよい。なお、本発明において、(C)成分としてピロキシリンを使用する場合には、ピロキシリンに内在する炭素数1〜4の一価アルコールは、前記(A)成分の一部を構成することになる。 Further, in the external preparation for reducing skin friction of the present invention, pyroxylin can also be used as the nitrocellulose. Pyroxylin is a solvent in which nitrocellulose is moistened, and specific examples thereof include a mixture of about 70% by weight of nitrocellulose and about 30% by weight of isopropanol. In the present invention, commercially available pyroxylin can also be used as the component (C). Specific examples of commercially available pyroxylin include T.I. N. C. Industrial Co. , Ltd made RS 1/32 sec, RS 1/16 sec, RS 1/8 sec, RS 1/8 L sec, RS 1/8 H sec, RS 1/4 sec, RS 1/4 H sec, RS 1/2 sec, RS 1 sec, RS 5-6 sec, RS 10-15 sec, RS 15-20 sec, RS 30-40 sec, RS 60-80 sec, RS 120 sec, RS 150 sec, RS 300 sec , RS 500 sec, RS 800 sec, RS 1200 sec, RS 2000 sec; RS 1/16, RS 1/8, RS 1/4, RS 1/2, RS 1, RS 2, RS 5 manufactured by Korea CNC Ltd. , RS 7, RS 20, RS 60, RS 120, RS 500, RS 1000, RS 2000 and the like. These may be used individually by 1 type, and may be used in combination of 2 or more type. In the present invention, when pyroxylin is used as the component (C), the monohydric alcohol having 1 to 4 carbon atoms contained in the pyroxylin constitutes a part of the component (A).
本発明の皮膚摩擦軽減用外用製剤において、(C)成分の含有量は、皮膚上で皮膜を形成可能であることを限度として、特に制限されないが、例えば、3.5〜14重量%、好ましくは5.6〜11.2重量%(ニトロセルロース70重量%とイソプロパノール30重量%の混合物であるピロキシリンを使用する場合、当該ピロキシリン含有量として、5〜20重量%、好ましくは8〜16重量%)が挙げられる。 In the external preparation for reducing skin friction of the present invention, the content of the component (C) is not particularly limited as long as a film can be formed on the skin, but is preferably 3.5 to 14% by weight, for example. When pyroxylin, which is a mixture of 70% by weight of nitrocellulose and 30% by weight of isopropanol, is used, the pyroxylin content is 5 to 20% by weight, preferably 8 to 16% by weight. ).
(D)皮膚上に形成された皮膜の突っ張り感を低減させる成分
本発明の皮膚摩擦軽減用外用製剤は、前記(A)〜(C)成分に加えて、グリチルリチン酸類、トコフェロール類、パンテノール類、ビタミンC類、ビタミンA類、ピリドキシン類、アラントイン類、及びアズレン類よりなる群から選択される少なくとも1種(以下、(D)成分と表記することもある)を含有してもよい。これらの(D)成分を含有することにより、皮膚上に形成された皮膜による突っ張り感を低減でき、関節等の可動域や足部に適用しても身体の動きに追従でき、破れたり、剥がれたりするのを抑制することができる。
(D) Ingredients that reduce the tension of the film formed on the skin The external preparation for reducing skin friction of the present invention contains glycyrrhizic acids, tocopherols, and panthenol in addition to the above components (A) to (C). , Vitamin Cs, Vitamin As, Pyridoxines, Allantoins, and Azulene may contain at least one selected from the group (hereinafter, may be referred to as component (D)). By containing these (D) components, it is possible to reduce the feeling of tension caused by the film formed on the skin, and even if it is applied to the range of motion of joints and the feet, it can follow the movement of the body, and it is torn or peeled off. It can be suppressed.
グリチルリチン酸類とは、グリチルリチン酸、その誘導体、及びそれらの塩であり、具体的には、グリチルリチン酸、グリチルリチン酸二カリウム、グリチルリチン酸モノアンモニウム、グリチルレチン酸、グリチルレチン酸グリセリン,グリチルレチン酸ステアリル,グリチルレチン酸ピリドキシン等が挙げられる。これらのグリチルリチン酸類の中でも、好ましくは、グリチルリチン酸、グリチルリチン酸二カリウム及びグリチルレチン酸が挙げられる。これらのグリチルリチン酸類は、1種単独で使用してもよく、また2種以上を組み合わせて使用してもよい。 Glycyrrhizic acids are glycyrrhizinic acid, derivatives thereof, and salts thereof. Specifically, glycyrrhizinic acid, dipotassium glycyrrhizinate, monoammonium glycyrrhizinate, glycyrrhetinic acid, glycerin glycyrrhetinate, stearyl glycyrrhetinate, and pyridoxin glycyrrhetinate. And so on. Among these glycyrrhizic acids, glycyrrhizic acid, dipotassium glycyrrhizinate and glycyrrhetinic acid are preferable. These glycyrrhizic acids may be used alone or in combination of two or more.
トコフェロール類とは、トコフェロール、及びその誘導体であり、具体的には、α−トコフェロール、β−トコフェロール、γ−トコフェロール、δ−トコフェロール、α−トコトリエノール、β−トコトリエノール、γ−トコトリエノール、δ−トコトリエノール、酢酸トコフェロール、リノール酸トコフェロール、ニコチン酸トコフェロール、(リノール酸/オレイン酸)トコフェロール等が挙げられる。これらのトコフェロール類の中でも、好ましくは、酢酸トコフェロールが挙げられる。これらのトコフェロール類は、1種単独で使用してもよく、また2種以上を組み合わせて使用してもよい。 Tocopherols are tocopherols and derivatives thereof, and specifically, α-tocopherol, β-tocopherol, γ-tocopherol, δ-tocopherol, α-tocotrienol, β-tocotrienol, γ-tocotrienol, δ-tocotrienol, Examples thereof include tocopherol acetate, tocopherol linoleate, tocopherol nicotinate, tocopherol (linoleic acid / oleic acid) and the like. Among these tocopherols, tocopherol acetate is preferable. These tocopherols may be used alone or in combination of two or more.
パンテノール類とは、パンテノール、その誘導体、及びそれらの塩であり、具体的には、パンテノール、パントテニルエチルエーテル、パントテン酸アルカリ土類金属塩(例えばカルシウム塩等)、パントテン酸アルカリ金属塩(例えばナトリウム塩等)、アセチルパントテニルエチルエーテル等が挙げられる。これらのパンテノール類の中でも、好ましくはパンテノールが挙げられる。これらのパンテノール類は、1種単独で使用してもよく、また2種以上を組み合わせて使用してもよい。 Pantenols are pantenols, derivatives thereof, and salts thereof. Specifically, pantenol, pantothenyl ethyl ether, alkaline earth metal pantothenate (for example, calcium salt, etc.), alkali metal pantothenate. Examples thereof include salts (for example, sodium salts and the like), acetylpantothenyl ethyl ether and the like. Among these panthenol types, panthenol is preferable. These panthenol types may be used alone or in combination of two or more.
ビタミンC類とは、アスコルビン酸、その誘導体、及びそれらの塩であり、具体的には、アスコルビン酸、アスコルビン酸モノアルキルエステル(例えば、アスコルビン酸モノステアレート、アスコルビン酸モノパルミテート、アスコルビン酸モノオレート、テトラへキシルデカン酸アスコルビル等)、アスコルビン酸ジアルキルエステル(例えば、アスコルビン酸ジステアレート、アスコルビン酸ジパルミテート、アスコルビン酸ジオレート)、アスコルビン酸トリアルキルエステル(例えば、アスコルビン酸トリステアレート、アスコルビン酸トリパルミテート、アスコルビン酸トリオレート等)等が挙げられる。これらのビタミンC類は、1種単独で使用してもよく、また2種以上を組み合わせて使用してもよい。 Vitamin Cs are ascorbic acid, derivatives thereof, and salts thereof, and specifically, ascorbic acid and ascorbic acid monoalkyl esters (for example, ascorbic acid monostearate, ascorbic acid monopalmitate, ascorbic acid monoolate). , Tetrahexyl decanoate ascorbyl, etc.), Ascorbic acid dialkyl ester (eg, ascorbic acid distearate, ascorbic acid dipalmitate, ascorbic acid diolate), ascorbic acid trialkyl ester (eg, ascorbic acid tristearate, ascorbic acid tripalmitate, ascorbin) Acid triolate, etc.) and the like. These vitamin Cs may be used alone or in combination of two or more.
ビタミンA類とは、ビタミンA及びその誘導体であり、具体的には、レチノール、レチナール、レチノイン酸、3−デヒドロレチノール、3−デヒドロレチナール、3−デヒドロレチノイン酸、水添レチノール、パルミチン酸レチノール、プロピオン酸レチノール、リノール酸レチノール、酢酸レチノール等が挙げられる。これらのビタミンA類は、1種単独で使用してもよく、また2種以上を組み合わせて使用してもよい。 Vitamin A is vitamin A and its derivatives, and specifically, retinol, retinal, retinoic acid, 3-dehydroretinol, 3-dehydroretinal, 3-dehydroretinoic acid, hydrogenated retinol, retinol palmitate, Examples thereof include retinol propionate, retinol linoleate, and retinol acetate. These vitamin As may be used alone or in combination of two or more.
ビタミンB6類とは、ビタミンB6、その誘導体、及びそれらの塩であり、具体的には、ピリドキシン、ピリドキサール、ピリドキサミン、これらの無機酸塩(例えば、塩酸塩、硫酸塩、硝酸塩、臭化水素酸塩、リン酸塩等)等が挙げられる。これらのビタミンB6類は、1種単独で使用してもよく、また2種以上を組み合わせて使用してもよい。 Vitamin B6s are vitamin B6, derivatives thereof, and salts thereof. Specifically, pyridoxine, pyridoxal, pyridoxamine, and inorganic acid salts thereof (for example, hydrochloride, sulfate, nitrate, hydrobromic acid). Salts, phosphates, etc.) and the like. These vitamin B6s may be used alone or in combination of two or more.
アラントイン類とは、アラントイン、及びその誘導体であり、具体的には、アラントイン、アラントインクロルヒドロキシアルミニウム、アラントインヒドロキシアルミニウム等が挙げられる。これらのアラントイン類は、1種単独で使用してもよく、また2種以上を組み合わせて使用してもよい。 The allantoins are allantoin and its derivatives, and specific examples thereof include allantoin, allantoin chlorohydroxyaluminum, and allantoinhydroxyaluminum. These allantoins may be used alone or in combination of two or more.
アズレン類とは、アズレン、その誘導体、及びそれらの塩であり、具体的には、アズレン、グアイアズレン、グアイアズレンスルホン酸、アズレンスルホン酸、アズレンスルホン酸ナトリウム、1,4−ジメチル−7−イソプロピルアズレン−3−スルホン酸等が挙げられる。これらのアズレン類は、1種単独で使用してもよく、また2種以上を組み合わせて使用してもよい。 Azulene species are azulene, derivatives thereof, and salts thereof. Specifically, azulene, guaiazulene, guaizulene sulfonic acid, azulene sulfonic acid, sodium azulene sulfonate, 1,4-dimethyl-7-isopropylazulene- Examples include 3-sulfonic acid. These azulene species may be used alone or in combination of two or more.
これらの(D)成分の中でも、皮膚上に形成させる皮膜の摩擦軽減作用を維持しつつ、使用時の突っ張り感をより一層効果的に低減させるという観点から、好ましくは、パンテノール類、トコフェロール類、グリチルリチン酸類;更に好ましくは、パンテノール、酢酸トコフェロール、グリチルレチン酸、グリチルリチン酸、グリチルリチン酸二カリウム;特に好ましくは、グリチルレチン酸、グリチルリチン酸、グリチルリチン酸二カリウムが挙げられる。 Among these (D) components, pantenols and tocopherols are preferable from the viewpoint of more effectively reducing the feeling of tension during use while maintaining the friction-reducing effect of the film formed on the skin. , Glycyrrhizinates; more preferably pantenol, tocopherol acetate, glycyrrhetinic acid, glycyrrhizic acid, dipotassium glycyrrhizinate; particularly preferably glycyrrhetinic acid, glycyrrhizic acid, dipotassium glycyrrhizinate.
これらの(D)成分は、1種単独で使用してもよく、また2種以上を組み合わせて使用してもよい。 These (D) components may be used alone or in combination of two or more.
本発明の皮膚摩擦軽減用外用製剤において、(D)成分を含有させる場合、その含有量については、特に制限されないが、例えば、0.05〜10重量%が挙げられる。皮膚上に形成させる皮膜の摩擦軽減作用を維持しつつ、使用時の突っ張り感をより一層効果的に低減させるという観点から、(D)成分の含有量として、好ましくは0.05〜8重量%、更に好ましくは0.1〜5重量%が挙げられる。 When the component (D) is contained in the external preparation for reducing skin friction of the present invention, the content thereof is not particularly limited, and examples thereof include 0.05 to 10% by weight. The content of the component (D) is preferably 0.05 to 8% by weight from the viewpoint of more effectively reducing the feeling of tension during use while maintaining the friction-reducing effect of the film formed on the skin. , More preferably 0.1 to 5% by weight.
(E)可塑剤
本発明の皮膚摩擦軽減用外用製剤は、皮膚上に形成させる皮膜に対して、良好な柔軟性や皮膚付着性を付与するために、必要に応じて、可塑剤(以下、(E)成分と表記することもある)を含んでいてもよい。
(E) Plasticizer The external preparation for reducing skin friction of the present invention is a plasticizer (hereinafter referred to as “plasticizer”), if necessary, in order to impart good flexibility and skin adhesion to the film formed on the skin. (E) It may be referred to as a component).
本発明で使用される可塑剤としては、薬学的に許容できるものであれば、特に制限されないが、例えば、植物油、炭素数5〜22のモノ、ジ又はトリカルボン酸と炭素数1〜9の一価アルコールのエステル、テルペノイド、多価アルコール、グリセリン脂肪酸エステル、鉱物油、ポリエーテル、ポリエステル等が挙げられる。 The plasticizer used in the present invention is not particularly limited as long as it is pharmaceutically acceptable, but for example, vegetable oil, mono, di or tricarboxylic acid having 5 to 22 carbon atoms and one of 1 to 9 carbon atoms. Hyprate alcohol esters, terpenoids, polyhydric alcohols, glycerin fatty acid esters, mineral oils, polyethers, polyesters and the like can be mentioned.
植物油としては、具体的には、ヒマシ油、綿実油、大豆油、ゴマ油、アルモンド油、ウイキョウ油、トウモロコシ油、オリブ油、オレンジ油、カミツレ油、ケイヒ油、小麦麦芽油、サフラワー油、シソ油、シトロネラー油、ショウキョウ油、スペアミント油、コメ油、チョウジ油、ツバキ油、テレビン油、トウヒ油、ナタネ油、ハッカ油、ヒマラヤスギ油、ヒマワリ油、ベルガモット油、ヤシ油、ユーカリ油、ラッカセイ油、ラベンダー油、卵黄油、レモン油、ローズ油、ロート油、ローマカミツレ油等が挙げられる。これらの植物油は、1種単独で使用してもよく、また2種以上を組み合わせて使用してもよい。 Specific examples of vegetable oils include castor oil, cottonseed oil, soybean oil, sesame oil, almond oil, oyster oil, corn oil, olive oil, orange oil, chamomile oil, kehi oil, wheat germ oil, saflower oil, and perilla oil. , Citronella oil, pepper oil, sparemint oil, rice oil, butterfly oil, camellia oil, television oil, peppermint oil, rapeseed oil, peppermint oil, sunflower oil, sunflower oil, bergamot oil, palm oil, eucalyptus oil, lacquer oil, Examples include lavender oil, egg yolk oil, lemon oil, rose oil, funnel oil, and Roman chamomile oil. These vegetable oils may be used alone or in combination of two or more.
炭素数5〜22のモノ、ジ又はトリカルボン酸と炭素数1〜9の一価アルコールのエステルとしては、具体的には、パルミチン酸イソプロピル、ミリスチン酸イソプロピル、ステアリン酸イソプロピル、リノール酸エチル、リノール酸イソプロピル、フタル酸ジメチル、フタル酸ジエチル、フタル酸ジプロピル、フタル酸ジブチル、フタル酸ジオクチル、アジピン酸ジイソブチル、アジピン酸ジイソプロピル、アジピン酸ジイソノニル、アジピン酸ジオクチル、セバシン酸ジエチル、セバシン酸ジイソプロピル、セバシン酸ジブチル、クエン酸トリエチル、クエン酸トリブチル、クエン酸アセチルトリブチル等が挙げられる。これらのエステルは、1種単独で使用してもよく、また2種以上を組み合わせて使用してもよい。 Specific examples of the ester of a mono, di or tricarboxylic acid having 5 to 22 carbon atoms and a monovalent alcohol having 1 to 9 carbon atoms include isopropyl palmitate, isopropyl myristate, isopropyl stearate, ethyl linoleate, and linoleic acid. Isopropyl, dimethyl phthalate, diethyl phthalate, dipropyl phthalate, dibutyl phthalate, dioctyl phthalate, diisobutyl adipate, diisopropyl adipate, diisononyl adipate, dioctyl adipate, diethyl sebacate, diisopropyl sebacate, dibutyl sebacate, Examples thereof include triethyl citrate, tributyl citrate, and acetyltributyl citrate. These esters may be used alone or in combination of two or more.
テルペノイドとしては、具体的には、カンフル、メントール、ボルネオール、シネオール、アネトール、リモネン、オイゲノール、ゲラニオール、ハッカ油等が挙げられる。これらのテルペノイドは、1種単独で使用してもよく、また2種以上を組み合わせて使用してもよい。 Specific examples of terpenoids include camphor, menthol, borneol, cineole, anethole, limonene, eugenol, geraniol, and mint oil. These terpenoids may be used alone or in combination of two or more.
多価アルコールとしては、具体的には、プロピレングリコール、グリセリン、ソルビトール等が挙げられる。これらの多価アルコールは、1種単独で使用してもよく、また2種以上を組み合わせて使用してもよい。 Specific examples of the polyhydric alcohol include propylene glycol, glycerin, and sorbitol. These polyhydric alcohols may be used alone or in combination of two or more.
グリセリン脂肪酸エステルとしては、具体的には、モノステアリン酸グリセリル、モノオレイン酸グリセリン、モノミリスチン酸グリセリン、ラウリン酸デカグリセリル、中鎖脂肪酸トリグリセリド等が挙げられる。これらのグリセリン脂肪酸エステルは、1種単独で使用してもよく、また2種以上を組み合わせて使用してもよい。 Specific examples of the glycerin fatty acid ester include glyceryl monostearate, glycerin monooleate, glycerin monomyristate, decaglyceryl laurate, and medium-chain fatty acid triglyceride. These glycerin fatty acid esters may be used alone or in combination of two or more.
鉱物油としては、具体的には、シリコーンオイル、流動パラフィン、ワセリン等が挙げられる。これらの鉱物油は、1種単独で使用してもよく、また2種以上を組み合わせて使用してもよい。 Specific examples of the mineral oil include silicone oil, liquid paraffin, petrolatum and the like. These mineral oils may be used alone or in combination of two or more.
ポリエーテルとしては、具体的には、ポリエチレングリコール等が挙げられる。 Specific examples of the polyether include polyethylene glycol and the like.
ポリエステルとしては、具体的には、アジピン酸ポリエステル等が挙げられる。 Specific examples of the polyester include polyester adipic acid and the like.
これらの可塑剤の中でも、好ましくは、植物油、炭素数5〜22のモノ、ジ又はトリカルボン酸と炭素数1〜9の一価アルコールのエステル、テルペノイド;更に好ましくは、ヒマシ油、パルミチン酸イソプロピル、ミリスチン酸イソプロピル、カンフルが挙げられる。 Among these plasticizers, preferably vegetable oils, mono-, di- or tricarboxylic acids having 5 to 22 carbon atoms, esters of monohydric alcohols having 1 to 9 carbon atoms, terpenoids; more preferably castor oil, isopropyl palmitate, etc. Examples include isopropyl myristate and camphor.
また、可塑剤は、皮膚摩擦軽減用外用製剤の皮膚上での展延性や皮膜の柔軟性を向上させるという利点がある反面、従来の皮膚摩擦軽減用外用製剤に配合すると、水との接触による製剤の顕著な白濁化を生じさせる一因になっていた。とりわけ植物油(特に、ヒマシ油)は、上記白濁化を誘発し易い可塑剤の一つである。これに対して、本発明によれば、植物油等の可塑剤を含有しても、前記(A)〜(C)成分を組み合わせて含むことにより、水との接触により生じる白濁化を有効に抑制することができる。このような本発明の効果に鑑みれば、本発明に配合される好適な可塑剤の例として、植物油(特に、ヒマシ油)が挙げられる。 In addition, the plasticizer has the advantage of improving the spreadability on the skin and the flexibility of the film of the external preparation for reducing skin friction, but when it is blended with the conventional external preparation for reducing skin friction, it causes contact with water. It contributed to the remarkable whitening of the preparation. In particular, vegetable oil (particularly castor oil) is one of the plasticizers that easily induce white turbidity. On the other hand, according to the present invention, even if a plasticizer such as vegetable oil is contained, the white turbidity caused by contact with water is effectively suppressed by containing the components (A) to (C) in combination. can do. In view of such effects of the present invention, examples of suitable plasticizers to be blended in the present invention include vegetable oils (particularly castor oil).
これらの可塑剤は、1種を単独で使用してもよく、また2種以上を組み合わせて使用してもよい。 One of these plasticizers may be used alone, or two or more of these plasticizers may be used in combination.
本発明の皮膚摩擦軽減用外用製剤において、(E)成分を含有させる場合、その含有量については、特に制限されないが、例えば、1〜40重量%、好ましくは2〜30重量%、更に好ましくは3〜20重量%、特に好ましくは5〜20重量%が挙げられる。 When the component (E) is contained in the external preparation for reducing skin friction of the present invention, the content thereof is not particularly limited, but is, for example, 1 to 40% by weight, preferably 2 to 30% by weight, more preferably. 3 to 20% by weight, particularly preferably 5 to 20% by weight.
その他の成分
本発明の皮膚摩擦軽減用外用製剤は、本発明の効果を妨げない範囲で、必要に応じて、水、アセトン、エチルメチルケトン、ジエチルエーテル等の溶剤を更に含んでいてもよい。但し、(A)及び(B)成分以外の溶剤は、皮膜の透明性を損なったり、水との接触による皮膜の白濁化やゲル化を生じ易くなったりすることがあるため、(A)及び(B)成分以外の溶剤を配合する場合には、かかる特性を考慮する必要がある。更に、ジエチルエーテルは、揮発性の高さに起因する発火性から製造上の取り扱いに注意が必要であり、また、保存中の乾燥による固化、特有の匂い等の原因にもなり得るので、ジエチルエーテルを配合する場合には、このような特性に配慮することが求められる。本発明の皮膚摩擦軽減用外用製剤における(A)及び(B)成分以外の溶剤の含有量としては、例えば、4重量%以下程度、特に2重量%以下程度であることが望ましい。
Other Ingredients The external preparation for reducing skin friction of the present invention may further contain a solvent such as water, acetone, ethyl methyl ketone and diethyl ether, if necessary, as long as the effects of the present invention are not impaired. However, solvents other than the components (A) and (B) may impair the transparency of the film, or may cause the film to become cloudy or gel due to contact with water. Therefore, (A) and When a solvent other than the component (B) is blended, it is necessary to consider such characteristics. Furthermore, diethyl ether requires careful handling in manufacturing due to its high volatility and is ignitable, and can also cause solidification due to drying during storage, a peculiar odor, and the like. When blending ether, it is required to consider such characteristics. The content of the solvent other than the components (A) and (B) in the external preparation for reducing skin friction of the present invention is preferably, for example, about 4% by weight or less, particularly about 2% by weight or less.
更に、本発明の皮膚摩擦軽減用外用製剤は、本発明の効果を妨げない範囲で、必要に応じて、(D)成分以外の薬効成分を含んでいてもよい。このような薬効成分としては、例えば、抗炎症剤、局所麻酔剤、鎮痛剤、抗ヒスタミン剤、殺菌剤、抗真菌剤、ビタミン類、保湿剤、美白剤、組織修復剤、皮膚保護剤、角質軟化剤、局所刺激剤、鎮痒剤、収斂剤、紫外防御剤、シリコンゲル、生薬エキス、アミノ酸類、ミネラル類等が挙げられる。 Further, the external preparation for reducing skin friction of the present invention may contain a medicinal ingredient other than the ingredient (D), if necessary, as long as the effect of the present invention is not impaired. Examples of such medicinal ingredients include anti-inflammatory agents, local anesthetics, analgesics, antihistamines, bactericides, antifungal agents, vitamins, moisturizers, whitening agents, tissue repair agents, skin protectants, and keratin softeners. , Local stimulants, antipruritic agents, astringents, ultraviolet protective agents, silicon gels, active drug extracts, amino acids, minerals and the like.
また、本発明の皮膚摩擦軽減用外用製剤は、本発明の効果を妨げない範囲で、必要に応じて、増粘剤、緩衝剤、キレート剤、抗酸化剤、安定化剤、乳化剤、防腐剤、香料、清涼化剤、着色剤、分散剤、流動化剤、粘稠化剤、増粘剤、吸着剤、保湿剤、湿潤剤、防湿剤、帯電防止剤等の添加剤を含んでいてもよい。 In addition, the external preparation for reducing skin friction of the present invention is a thickener, a buffer, a chelating agent, an antioxidant, a stabilizer, an emulsifier, and a preservative, as necessary, as long as the effects of the present invention are not impaired. , Fragrances, refreshing agents, coloring agents, dispersants, fluidizing agents, thickening agents, thickeners, adsorbents, moisturizers, wetting agents, moisture-proofing agents, antistatic agents, etc. Good.
皮膚摩擦軽減用外用製剤の製造方法
本発明の皮膚摩擦軽減用外用製剤は、上記(A)〜(C)成分、及び必要に応じて、上記(D)成分、他の溶剤、薬効成分、添加剤等を所望量混合することにより調製される。
Method for manufacturing an external preparation for reducing skin friction The external preparation for reducing skin friction of the present invention comprises the above components (A) to (C), and if necessary, the above (D) component, other solvent, medicinal ingredient, and addition. It is prepared by mixing a desired amount of an agent or the like.
皮膚摩擦軽減用外用製剤の使用方法
本発明の皮膚摩擦軽減用外用製剤は、皮膚に対する摩擦を軽減するために、摩擦が付加される皮膚部位に塗布することにより使用される。
How to use the external preparation for reducing skin friction The external preparation for reducing skin friction of the present invention is used by applying it to a skin site to which friction is applied in order to reduce friction on the skin.
本発明の皮膚摩擦軽減用外用製剤を塗布した皮膚部位では、摩擦軽減作用が高い皮膜が形成され、当該皮膚部位において摩擦が軽減される。 A film having a high friction-reducing effect is formed on the skin portion to which the external preparation for reducing skin friction of the present invention is applied, and the friction is reduced at the skin portion.
本発明の皮膚摩擦軽減用外用製剤が適用される皮膚部位については、摩擦の軽減が求められている部位であれば、特に制限されず、上肢、下肢、胸部、腹部、背部、腰部等のいずれであってもよい。また、本発明の皮膚摩擦軽減用外用製剤は、(D)成分を含有している場合には、皮膚上で破れ難く頑丈で、しかも突っ張り感が低減された皮膜を形成できるので、足首、手首、肘、膝、指等の関節がある可動域、足背部、足底部、踵等に対して適用しても、破れにくく身体の動きに追従することが可能になっている。 The skin site to which the external preparation for reducing skin friction of the present invention is applied is not particularly limited as long as it is a site where reduction of friction is required, and any of the upper limbs, lower limbs, chest, abdomen, back, waist, etc. It may be. Further, when the external preparation for reducing skin friction of the present invention contains the component (D), it can form a tough film that is hard to tear on the skin and has a reduced feeling of tension, so that the ankles and wrists can be formed. Even if it is applied to a range of motion with joints such as elbows, knees, and fingers, the back of the foot, the sole of the foot, and the heel, it is difficult to tear and it is possible to follow the movement of the body.
本発明の皮膚摩擦軽減用外用製剤は、皮膚に対する摩擦の軽減が求められている様々な用途に適用することができる。例えば、本発明の皮膚摩擦軽減用外用製剤は、下着や靴下等によって締め付けられる皮膚部位に適用することによってかぶれを予防したり、床ずれが生じやすい皮膚部位に適用することによって床ずれを予防したりすることができる。また、本発明の皮膚摩擦軽減用外用製剤は、靴擦れが生じ易い足背、足底、足指、踵等に適用することによって靴擦れを防止することができる。更に、本発明は、指輪等のアクセサリーを装着する手指等に適用することにより、アクセサリーと皮膚間の摩擦を軽減してアクセサリーの脱着を容易にすることもできる。 The external preparation for reducing skin friction of the present invention can be applied to various applications in which reduction of friction on the skin is required. For example, the external preparation for reducing skin friction of the present invention can prevent rashes by applying it to skin parts tightened by underwear, socks, etc., or prevent bedsores by applying it to skin parts where bedsores are likely to occur. be able to. In addition, the external preparation for reducing skin friction of the present invention can prevent shoe rubbing by being applied to the back of the foot, sole, toes, heel, etc., where shoe rubbing is likely to occur. Further, by applying the present invention to a finger or the like on which an accessory such as a ring is attached, friction between the accessory and the skin can be reduced and the attachment and detachment of the accessory can be facilitated.
本発明の皮膚摩擦軽減用外用製剤を皮膚に塗布する方法については、特に制限されず、例えば、指での塗布、チューブの容器口を用いた直接塗布、刷毛やヘラ等を用いた塗布等による方法であればよいが、使用者の利便性の観点から、刷毛を用いた塗布が好ましい。また、使用者の利便性を高めるために、本発明の皮膚摩擦軽減用外用製剤は、刷毛が付属された容器に収容して提供されることが望ましい。 The method of applying the external preparation for reducing skin friction of the present invention to the skin is not particularly limited, and is, for example, application by a finger, direct application using the container mouth of a tube, application using a brush, a spatula, or the like. Any method may be used, but from the viewpoint of user convenience, application using a brush is preferable. Further, in order to enhance the convenience of the user, it is desirable that the external preparation for reducing skin friction of the present invention is provided in a container to which a brush is attached.
以下に実施例を示して本発明をより具体的に説明するが、本発明はこれらに限定されるものではない。なお、以下の実施例、比較例、及び処方例において、ニトロセルロース源として、ピロキシリン(ニトロセルロース:イソプロピルアルコールの重量比が7:3)を使用した。 The present invention will be described in more detail with reference to Examples below, but the present invention is not limited thereto. In the following Examples, Comparative Examples, and Formulation Examples, pyroxylin (nitrocellulose: isopropyl alcohol weight ratio: 7: 3) was used as the nitrocellulose source.
試験例1:摩擦軽減作用の評価
1.皮膚摩擦軽減用外用製剤の調製
表1に示す組成の皮膚摩擦軽減用外用製剤を調製した。具体的には、(A)成分、(D)成分、及び(E)成分を攪拌混合し、これに(C)成分を添加して分散させた後、(B)成分を加えて均一に攪拌溶解して皮膚摩擦軽減用外用製剤(実施例1〜7)を得た。
Test Example 1: Evaluation of friction reducing effect 1. Preparation of External Preparation for Reducing Skin Friction An external preparation for reducing skin friction having the composition shown in Table 1 was prepared. Specifically, the components (A), (D), and (E) are stirred and mixed, and the component (C) is added to and dispersed, and then the component (B) is added and stirred uniformly. It was dissolved to obtain an external preparation for reducing skin friction (Examples 1 to 7).
2.摩擦軽減作用の評価方法
人工皮膚(商品名「バイオスキン」、株式会社ビューラックス製)に各皮膚摩擦軽減用外用製剤0.2gを一定範囲(2cm×5cm)に塗布し、室温で一日乾燥させて、人工皮膚上に皮膜を形成させた。人工皮膚上に形成させた皮膜の摩擦係数を摩擦感テスターKES-SE(カトーテック株式会社製)を用いて測定した。摩擦係数の測定は、ジグ上に25gの荷重の下、1mm/秒の速度に設定して行い、測定範囲(20mm)の平均摩擦係数を求めた。なお、ジグのセンサーオプションには10mm角ピアノワイヤを用いた。
2. Evaluation method of friction reduction effect 0.2 g of each skin friction reduction external preparation is applied to artificial skin (trade name "Bioskin", manufactured by Bulux Co., Ltd.) in a certain range (2 cm x 5 cm) and dried at room temperature for one day. A film was formed on the artificial skin. The coefficient of friction of the film formed on the artificial skin was measured using a friction tester KES-SE (manufactured by Kato Tech Co., Ltd.). The coefficient of friction was measured under a load of 25 g on the jig at a speed of 1 mm / sec, and the average coefficient of friction in the measurement range (20 mm) was obtained. A 10mm square piano wire was used as the jig sensor option.
また、比較として、皮膚摩擦軽減用外用製剤を塗布していない人工皮膚(比較例1)、及び絆創膏(商品名「バンドエイドキズパワーパッド靴ずれ用」、ジョンソン・エンド・ジョンソン株式会社製)を貼付した人工皮膚の絆創膏の貼付面(比較例2)についても、前記と同条件で摩擦係数の測定を行った。また、比較例1で測定された平均摩擦係数を100として、実施例1〜7及び比較例2で測定された平均摩擦係数の相対値についても算出した For comparison, artificial skin to which no external preparation for reducing skin friction (Comparative Example 1) and adhesive plaster (trade name "Band-Aid Scratch Power Pad for Shoe Slip", manufactured by Johnson & Johnson Co., Ltd.) are attached. The friction coefficient was also measured on the skin adhesive plaster-attached surface (Comparative Example 2) under the same conditions as described above. Further, the relative value of the average friction coefficient measured in Examples 1 to 7 and Comparative Example 2 was also calculated, assuming that the average friction coefficient measured in Comparative Example 1 was 100.
3.評価結果
得られた結果を表1に示す。(A)〜(C)成分を含有する皮膚摩擦軽減用外用製剤(実施例1〜7)は、いずれも塗布部の摩擦力を軽減させることができていた。また、(A)〜(C)成分に加えて(D)成分及び/又は(E)成分を含有する皮膚摩擦軽減用外用製剤(実施例1〜5)でも、摩擦低減作用が認められ、特にグリチルレチン酸又は酢酸トコフェロールを含有する皮膚摩擦軽減用外用製剤(実施例1及び3)における摩擦低減作用が高かった。更に、(E)成分を含有していない皮膚摩擦軽減用外用製剤(実施例6及び7)では、特に優れた摩擦低減作用が認められた。
3. 3. Evaluation Results Table 1 shows the obtained results. All of the external preparations for reducing skin friction (Examples 1 to 7) containing the components (A) to (C) were able to reduce the frictional force of the coated portion. Further, in addition to the components (A) to (C), the external preparation for skin friction reduction (Examples 1 to 5) containing the component (D) and / or the component (E) also has a friction reducing effect, and in particular. The friction reducing effect was high in the external preparations for reducing skin friction (Examples 1 and 3) containing glycyrrhetinic acid or tocopherol acetate. Further, in the external preparations for reducing skin friction (Examples 6 and 7) containing no component (E), a particularly excellent friction reducing effect was observed.
試験例2:突っ張り感の評価
1.皮膚摩擦軽減用外用製剤の調製
表2に示す組成の皮膚摩擦軽減用外用製剤を調製した。具体的には、(A)成分及び(D)成分を攪拌混合し、これに(C)成分を添加して分散させた後、(B)成分を加えて均一に攪拌溶解して皮膚摩擦軽減用外用製剤(実施例6〜14)を得た。
Test Example 2: Evaluation of tension 1. Preparation of External Preparation for Reducing Skin Friction An external preparation for reducing skin friction having the composition shown in Table 2 was prepared. Specifically, the components (A) and (D) are stirred and mixed, and the component (C) is added to and dispersed, and then the component (B) is added and uniformly stirred and dissolved to reduce skin friction. External preparations (Examples 6 to 14) were obtained.
2.突っ張り感の評価方法
2cmにカットしたゴムひも(商品名「ソフトゴム8コール」、貝印株式会社製)をまっすぐの状態で表面(0.5cm×1cm)に皮膚摩擦軽減用外用製剤0.2gを塗布し、室温で約2時間乾燥させ皮膜を形成させた。次いで、皮膚摩擦軽減用外用製剤を塗布した部位の中心部を起点として、ゴムひもの一方の辺が他方の辺に接するようにゴムひもを折りたたんで、その後、手を離し3秒後に写真を撮影した。ゴムひもが前記起点で形成している角度(ゴムひもの復元角度、前記一方の辺と他方の辺によって形成されている角度)を分度器にて計測した。3回の計測の平均値を表に示した。また、実施例6で測定されたゴムひもの平均復元角度を100として、実施例7〜14で測定されたゴムひもの平均復元角度の相対値についても算出した。
2. Evaluation method of tension feeling A rubber string cut to 2 cm (trade name "Soft Rubber 8 Call", manufactured by Kai Corporation) is placed straight on the surface (0.5 cm x 1 cm) with 0.2 g of an external preparation for reducing skin friction. It was applied and dried at room temperature for about 2 hours to form a film. Next, starting from the center of the site where the external preparation for reducing skin friction was applied, fold the elastic cord so that one side of the elastic cord touches the other side, and then take a photo 3 seconds after releasing the hand. did. The angle formed by the elastic cord at the starting point (restoration angle of the elastic cord, the angle formed by the one side and the other side) was measured with a protractor. The average value of the three measurements is shown in the table. Further, the relative value of the average restoration angle of the elastic cord measured in Examples 7-14 was also calculated, assuming that the average restoration angle of the elastic cord measured in Example 6 was 100.
本評価方法では、復元角度が大きい程、ゴムひも上に形成された皮膜の形状保持特性が大きく、皮膚上での突っ張り感が大きいことを示し、復元角度が小さい程、ゴムひも上に形成された皮膜の形状保持特性が小さく、皮膚上での突っ張り感が小さいことを示している。 In this evaluation method, the larger the restoration angle, the greater the shape-retaining characteristics of the film formed on the rubber string, and the greater the feeling of tension on the skin, and the smaller the restoration angle, the greater the shape retention characteristic of the film formed on the rubber string. It shows that the shape-retaining property of the film is small and the feeling of tension on the skin is small.
3.評価結果
得られた結果を表3に示す。この結果から、(A)〜(C)成分に加えて、(D)成分を含有する皮膚摩擦軽減用外用製剤(実施例7〜14)では、(D)成分を含まない皮膚摩擦軽減用外用製剤(実施例6)に比べて、ゴムひもの復元角度が小さくなっており、突っ張り感を低減できていた。とりわけ、(D)成分としてグリチルレチン酸を含む皮膚摩擦軽減用外用製剤(実施例9〜12)では、突っ張り感の低減効果が格段に優れていた。
3. 3. Evaluation Results Table 3 shows the obtained results. From this result, in the external preparations for reducing skin friction containing the component (D) in addition to the components (A) to (C) (Examples 7 to 14), the external preparation for reducing skin friction not containing the component (D) was used. Compared with the preparation (Example 6), the restoration angle of the rubber string was smaller, and the feeling of tension could be reduced. In particular, the external preparations for reducing skin friction (Examples 9 to 12) containing glycyrrhetinic acid as the component (D) were remarkably excellent in the effect of reducing the feeling of tension.
試験例3:靴擦れ予防効果の評価
前記試験例1及び2にて調製した皮膚摩擦軽減用外用製剤(実施例1、2、4及び6)について、靴擦れ予防効果について評価した。具体的には、履くと靴ずれしやすい靴を所有する被験者6人を対象に、各皮膚摩擦軽減用外用製剤を、靴ずれしやすい部分(皮膚)に刷毛で塗布して乾燥させた後、靴を履いて1日(8時間)外出してもらった。その後、各被験者における靴ずれの有無を観察した。
Test Example 3: Evaluation of Shoe Rubbing Preventing Effect The external preparation for reducing skin friction (Examples 1, 2, 4 and 6) prepared in Test Examples 1 and 2 was evaluated for the shoe rubbing preventing effect. Specifically, for 6 subjects who own shoes that are prone to slipping when worn, each external preparation for reducing skin friction is applied with a brush to the part (skin) that is prone to slipping, and then the shoes are worn. I wore it and had him go out for a day (8 hours). After that, the presence or absence of slippage of shoes was observed in each subject.
いずれの皮膚摩擦軽減用外用製剤(実施例1、2、4及び6)でも、被験者に靴ずれは認められず、摩擦低減効果によって靴ずれを予防できていた。より具体的には、実施例6の皮膚摩擦軽減用外用製剤では、摩擦低減作用が高く、靴ずれを予防できたものの、皮膚の突っ張り感がやや感じられ、皮膚上に形成された皮膜が歩行時の足の動きに追随し難く、やや破れやすい傾向が見られた。一方、実施例1、2及び4の皮膚摩擦軽減用外用製剤では、摩擦低減作用と皮膚の突っ張り感の低減作用のバランスに優れており、特に靴ずれ予防効果に優れていた。なお、皮膚摩擦軽減用外用製剤を使用した試験終了後、当該皮膚摩擦軽減用外用製剤を塗布しないこと以外は、前記同様に試験を行ったところ、被験者のうち3人に靴ずれの症状が認められた。 In any of the external preparations for reducing skin friction (Examples 1, 2, 4 and 6), no slippage was observed in the subjects, and the slippage could be prevented by the friction reduction effect. More specifically, in the external preparation for reducing skin friction of Example 6, the friction reducing effect was high and the slippage of the shoes could be prevented, but the skin was slightly stretched, and the film formed on the skin was formed during walking. It was difficult to follow the movement of the foot, and there was a tendency for it to tear a little. On the other hand, the external preparations for reducing skin friction of Examples 1, 2 and 4 were excellent in the balance between the friction reducing effect and the skin tension reducing effect, and were particularly excellent in the shoe slip prevention effect. After the test using the external preparation for reducing skin friction was completed, the same test as above was performed except that the external preparation for reducing skin friction was not applied. As a result, 3 of the subjects showed symptoms of slippage. It was.
処方例
表3及び4に示す組成の皮膚摩擦軽減用外用製剤を、前記試験例1に記載する「1.皮膚摩擦軽減用外用製剤の調製」と同様の方法で製造した。得られた皮膚摩擦軽減用外用製剤を前記試験例1及び2と同様に評価したところ、摩擦低減作用が高く、突っ張り感の低減効果が優れていた。
Formulation Examples The external preparations for reducing skin friction having the compositions shown in Tables 3 and 4 were produced in the same manner as in "1. Preparation of external preparations for reducing skin friction" described in Test Example 1. When the obtained external preparation for reducing skin friction was evaluated in the same manner as in Test Examples 1 and 2, the friction reducing effect was high and the tension reducing effect was excellent.
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JP2019006713A (en) * | 2017-06-26 | 2019-01-17 | 小林製薬株式会社 | Film forming external preparation |
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JP6968589B2 (en) * | 2017-06-26 | 2021-11-17 | 小林製薬株式会社 | Film-forming external preparation |
JP2020083818A (en) * | 2018-11-27 | 2020-06-04 | 英昌化学工業株式会社 | Spray for forming protective film on skin surface |
JP7241528B2 (en) * | 2018-12-20 | 2023-03-17 | 小林製薬株式会社 | Film-forming external preparation |
JP7241529B2 (en) * | 2018-12-20 | 2023-03-17 | 小林製薬株式会社 | Film-forming external preparation |
JP7241527B2 (en) * | 2018-12-20 | 2023-03-17 | 小林製薬株式会社 | Film-forming external preparation |
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JPS63161508U (en) * | 1987-04-10 | 1988-10-21 | ||
US5102654A (en) * | 1990-04-18 | 1992-04-07 | Revlon, Inc. | Nail enamel emulsion lacquer comprising a water phase and a lacquer phase |
JPH09132516A (en) * | 1995-11-10 | 1997-05-20 | Kao Corp | Nonfoaming gel shaving composition |
JP3045423U (en) * | 1997-07-17 | 1998-02-03 | ニチニチ製薬株式会社 | Shoe slip prevention tape |
WO2000076366A1 (en) * | 1999-06-11 | 2000-12-21 | Phoenix Engineering Corp. | Artificial nail forming method and set of artificial nail forming implements |
US6337076B1 (en) * | 1999-11-17 | 2002-01-08 | Sg Licensing Corporation | Method and composition for the treatment of scars |
JP2001335414A (en) * | 2000-05-29 | 2001-12-04 | Kanebo Ltd | Cosmetic |
EP1300130B1 (en) * | 2000-07-13 | 2009-09-30 | Shiseido Co., Ltd. | Gel composition and nail enamel |
US6485731B2 (en) * | 2001-01-08 | 2002-11-26 | Revlon Consumer Products Corporation | Method for improving integrity of cosmetic films |
JP2007217346A (en) * | 2006-02-16 | 2007-08-30 | Kose Corp | Shaving composition |
JP5137175B2 (en) * | 2006-10-24 | 2013-02-06 | 有限会社日本健康科学研究センター | Film guard formulation |
WO2008050491A1 (en) * | 2006-10-24 | 2008-05-02 | Japan Health Science Research Center.Ltd. | Film preparation for forming film on skin |
JP5396125B2 (en) * | 2009-03-30 | 2014-01-22 | 有限会社日本健康科学研究センター | Film-forming formulation |
JP5798561B2 (en) * | 2009-10-08 | 2015-10-21 | エムエスディー コンシューマー ケア, インコーポレイテッド | Low ether composition and delivery device |
WO2011071795A1 (en) * | 2009-12-07 | 2011-06-16 | Susanne Lang Fragrance Inc. | Peelable, water-based nail cosmetic system |
CN102058900B (en) * | 2010-12-13 | 2013-09-04 | 都本立 | Waterproof liquid bandage for wound surface protection and preparation method thereof |
FR2972923B1 (en) * | 2011-03-25 | 2013-08-23 | Urgo Lab | FILMOGENIC COMPOSITION CONTAINING A SOLAR FILTER, ITS USE FOR THE TREATMENT OF SCARS |
FR2972928B1 (en) * | 2011-03-25 | 2013-11-29 | Urgo Lab | COMPOSITION CONTAINING CELLULOSE, VEGETABLE OIL AND VOLATILE SOLVENT, ITS USES AS DRESSING |
JP5950528B2 (en) * | 2011-09-30 | 2016-07-13 | 小林製薬株式会社 | Film-forming external preparation |
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JP2019006713A (en) * | 2017-06-26 | 2019-01-17 | 小林製薬株式会社 | Film forming external preparation |
JP7048221B2 (en) | 2017-06-26 | 2022-04-05 | 小林製薬株式会社 | Film-forming external preparation |
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CN108778234A (en) | 2018-11-09 |
JP2017171583A (en) | 2017-09-28 |
WO2017159852A1 (en) | 2017-09-21 |
CN108778234B (en) | 2022-02-08 |
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