JP7241527B2 - Film-forming external preparation - Google Patents

Description

The present invention relates to a film-forming topical preparation. More particularly, the present invention relates to film-forming topical preparations thickened to provide good spreadability with a small brush.

Adhesive bandages are known as sanitary materials for preventing skin damage such as cracks, chaps, bruises, cuts, etc. from invasion and infection by bacteria. Adhesive plasters can be broadly divided into tape-type plasters, in which gauze or an absorbent pad is attached to the center of a tape base layered with adhesive, and liquid plasters, which are liquid before use but form a film when applied to the skin. separated. Of these, liquid bandages do not use adhesives, which reduces the physical irritation when peeling off. Furthermore, by selectively applying them to the damaged area, the film can be formed according to the size and shape of the damaged area. Since it can be formed, it is attracting attention as a means of compensating for the above-mentioned drawbacks of the tape-shaped bandage.

Conventionally, nitrocellulose has been used as a film-forming component in liquid bandages, and various formulations of liquid bandages using nitrocellulose have been reported. For example, Patent Document 1 discloses a film guard formulation prepared by dissolving nitrocellulose in 3-methylbutyl acetate, isobutyl acetate or acetone and adding ethyl alcohol.

On the other hand, a liquid adhesive bandage with a formulation different from the above has also been reported. A skin protectant comprising 60-99% by weight of a volatile hydrophobic solvent is disclosed. Patent Document 2 describes that a volatile hydrophobic solvent has excellent properties in terms of applicability in addition to relieving irritation. Viscosity modifiers such as vegetable oils, animal oils, diisopropyl adipate, etc., menthol, camphor, glycerol triacetate, cholesterol, cholesterol derivatives, fumed silica, bentonite and other clay derivatives are disclosed.

JP 2008-105979 A JP 2014-204832 A

In order for the film formed on the skin by the liquid bandage to satisfactorily exhibit the protective function inherently provided by the bandage, it must be applied in a sufficient amount to form a film. In order to obtain good applicability to the skin, the present inventor focused on a liquid adhesive plaster that is housed in a container with a brush and applied with a brush. However, the liquid adhesive plaster that is applied with a brush has a low viscosity, unlike the liquid adhesive plaster that is housed in a tube container, and it is difficult to apply a sufficient amount in one application. Furthermore, in order to make it easier to apply to skin areas with relatively complex surface shapes and skin areas with relatively small wounds, if it is stored in a container equipped with a small brush, the amount of liquid that the brush can hold is inevitably limited. As a result, the problem of increasing the difficulty of applying a sufficient amount in one coat was faced. In addition, for areas with relatively complex surface shapes and relatively small wounds, such as fingers, which move frequently on a daily basis, are easily exposed to various external factors, and are particularly sensitive to pain due to wounds. Since there are many parts such as , the adverse effect caused by the difficulty of applying a sufficient amount in one coat is very large.

SUMMARY OF THE INVENTION Accordingly, it is an object of the present invention to provide a film-forming preparation for external use that has excellent applicability that allows a sufficient amount to be applied in one application while being housed in a container equipped with a small brush of a predetermined size.

As a result of intensive studies, the present inventors have found (A) a monohydric alcohol having 1 to 4 carbon atoms, (B) an ester of a monocarboxylic acid having 2 to 4 carbon atoms and a monohydric alcohol having 1 to 5 carbon atoms, and ( C) In film-forming external preparations containing nitrocellulose, (D) Glycyrrhetinic acid, derivatives thereof, and/or salts thereof (hereinafter referred to as glycyrrhetin (also referred to as acids) unexpectedly increases the viscosity of the film-forming preparation for external use, making it possible to easily apply a sufficient amount in one coat even with a small brush of a predetermined size. . The present invention was completed by further studies based on this finding.

That is, the present invention provides inventions in the following aspects.
Section 1. (A) a monohydric alcohol having 1 to 4 carbon atoms, (B) an ester of a monocarboxylic acid having 2 to 4 carbon atoms and a monohydric alcohol having 1 to 5 carbon atoms, (C) nitrocellulose, and (D) glycyrrhetin including acids, derivatives thereof, and/or salts thereof;
It is housed in a container having a container body and a lid portion provided with an application member that enters into the container body, and the application member has a handle and a brush provided at the end of the handle. and a film-forming preparation for external use, wherein the length from the base end to the tip of the brush is 11 to 13 mm, and the width of the tip is 1.5 to 4.5 mm.
Section 2. Item 1. The film-forming preparation for external use according to Item 1, which is used for application to fingers.
Item 3. Item 3. The film-forming preparation for external use according to Item 1 or 2, which is used for application to wounds on the skin.
Section 4. Item 4. The film-forming preparation for external use according to any one of Items 1 to 3, which has a viscosity of 5000 to 15000 mPa·s.
Item 5. (A) a monohydric alcohol having 1 to 4 carbon atoms, (B) an ester of a monocarboxylic acid having 2 to 4 carbon atoms and a monohydric alcohol having 1 to 5 carbon atoms, and (C) nitrocellulose,
It is housed in a container having a container body and a lid portion provided with an application member that enters into the container body, and the application member has a handle and a brush provided at the end of the handle. and, in the film-forming preparation for external use, wherein the length from the base end to the tip of the brush is 11 to 13 mm and the width of the tip is 1.5 to 4.5 mm,
(D) A method for thickening a film-forming external preparation, which comprises blending glycyrrhetinic acid, a derivative thereof, and/or a salt thereof.

ADVANTAGE OF THE INVENTION According to the present invention, there is provided a film-forming preparation for external use having excellent applicability that allows a sufficient amount to be applied in one application while being housed in a container equipped with a small brush of a predetermined size.

An example of a lid part provided with an application member is shown typically.

1. Film-Forming Preparation for External Use The film-forming preparation for external use of the present invention comprises (A) a specific alcohol (hereinafter also referred to as component (A)) and (B) a specific ester (hereinafter also referred to as component (B)). , (C) nitrocellulose (hereinafter also referred to as component (C)), and (D) glycyrrhetinic acids (hereinafter also referred to as component (D)), and housed in a container having a brush portion of a predetermined size It is characterized by The film-forming preparation for external use of the present invention is described in detail below.

(A) Monohydric alcohol having 1 to 4 carbon atoms The film-forming preparation for external use of the present invention contains a monohydric alcohol having 1 to 4 carbon atoms as component (A).

The type of monohydric alcohol having 1 to 4 carbon atoms is not particularly limited, but examples include methanol, ethanol, n-propanol, isopropanol, n-butanol, sec-butanol, isobutanol and tert-butanol. Among these alcohols, monohydric alcohols having 2 to 4 carbon atoms are preferred, ethanol, isopropanol and n-butanol are more preferred, and ethanol and isopropanol are more preferred.

In the film-forming preparation for external use of the present invention, as component (A), monohydric alcohols with 1 to 4 carbon atoms may be used singly or in combination of two or more. good.

Isopropanol is a preferred embodiment of the component (A) from the viewpoint of obtaining even better coatability.

In the film-forming external preparation of the present invention, the content of component (A) is not particularly limited, but is, for example, 10 to 70% by weight, preferably 15 to 65% by weight, more preferably 30 to 60% by weight, More preferably 30 to 60% by weight, particularly preferably 35 to 60% by weight. By satisfying the content of the component (A), even better coatability can be obtained.

(B) an ester of a monocarboxylic acid having 2 to 4 carbon atoms and a monohydric alcohol having 1 to 5 carbon atoms. and an ester with a monohydric alcohol having 1 to 5 carbon atoms. "Ester of a monocarboxylic acid having 2 to 4 carbon atoms and a monohydric alcohol having 1 to 5 carbon atoms" is one molecule of monocarboxylic acid having 2 to 4 carbon atoms and one molecule of monohydric alcohol having 1 to 5 carbon atoms. is an ester-bonded compound.

The type of monocarboxylic acid having 2 to 4 carbon atoms that constitutes the ester is not particularly limited, but examples thereof include acetic acid, lactic acid, propionic acid, and butyric acid. Among these monocarboxylic acids, monocarboxylic acids having 2 or 3 carbon atoms are preferred, and acetic acid and lactic acid are more preferred.

In addition, the type of monohydric alcohol having 1 to 5 carbon atoms constituting the ester is not particularly limited, but examples include methanol, ethanol, n-propanol, isopropanol, n-butanol, sec-butanol, isobutanol, tert. -butanol, benzyl alcohol, 1-pentanol, 3-methyl-1-butanol, 2-methyl-1-butanol, 2,2 dimethyl-1-propanol, 2-pentanol, 3-methyl-2-butanol, 3 -pentanol, 2-methyl-2-butanol. Among these alcohols, preferably methanol, ethanol, n-propanol, isopropanol, n-butanol, 1-pentanol and benzyl alcohol, more preferably ethanol, n-propanol, isopropanol, n-butanol and 1-pentanol is mentioned.

Specific examples of the ester include methyl acetate, ethyl acetate, propyl acetate (n-propyl acetate), isopropyl acetate, butyl acetate (n-butyl acetate), sec-butyl acetate, isobutyl acetate, pentyl acetate (1- pentyl), ethyl lactate, butyl lactate, isoamyl acetate (3-methylbutyl acetate), ethyl butyrate, ethyl propionate and the like. Among these, from the viewpoint of obtaining even better coatability, the ester preferably includes ethyl acetate, butyl acetate and ethyl lactate; more preferably ethyl acetate and butyl acetate.

In the film-forming preparation for external use of the present invention, as the component (B), one of the above esters may be used alone, or two or more thereof may be used in combination. For example, by using a combination of two or more esters having different boiling points as component (B), the film-forming rate of the film-forming external preparation of the present invention can be adjusted appropriately. For example, if the ester having a boiling point of less than 100°C (e.g., ethyl acetate) and the ester having a boiling point of 100°C or higher (e.g., butyl acetate) are used in combination, and the ratio of the ester having a boiling point of less than 100°C is set high, If the ratio of the above-mentioned ester having a boiling point of less than 100° C. is set low, the film formation speed can be slowed down.

As a suitable example of component (B), ethyl acetate and butyl acetate are used in combination, and 0.05 to 0.5 parts by weight, preferably 0.07 to 0.4 parts by weight, of butyl acetate is used per 1 part by weight of ethyl acetate. Part by weight, more preferably a ratio of 0.1 to 0.3 parts by weight. By using ethyl acetate and butyl acetate together in such a ratio, it is possible to form a film at an appropriate film-forming speed when applied to the skin.

In the film-forming preparation for external use of the present invention, the content of component (B) is not particularly limited, and may be appropriately set according to the type of component (B) and the film-forming speed to be provided. , 25 to 65% by weight, preferably 25 to 60% by weight, more preferably 30 to 55% by weight, and still more preferably 33 to 52% by weight.

In the film-forming external preparation of the present invention, the ratio of component (B) to component (A) may be appropriately set within a range that satisfies the respective contents of these two components. 0.2 to 10 parts by weight of component (B) can be used per 1 part by weight.

The ratio of component (B) to component (A) is preferably 0.3 to 5 parts by weight per 1 part by weight of component (A), from the viewpoint of obtaining even better coating properties. , more preferably 0.4 to 3 parts by weight, still more preferably 0.5 to 2 parts by weight, and particularly preferably 0.6 to 1.5 parts by weight.

(C) Nitrocellulose The film-forming preparation for external use of the present invention contains nitrocellulose as component (C). Nitrocellulose serves as the base for the film that forms on the skin.

The nitrocellulose used in the present invention is not particularly limited in its molecular weight, nitrogen content, etc., as long as it can form a film on the skin.

Pyroxyline can also be used as nitrocellulose in the film-forming external preparation of the present invention. Pyroxyline is nitrocellulose moistened with a solvent. Specifically, a mixture of about 70% by weight of nitrocellulose and about 30% by weight of isopropanol can be mentioned. In the present invention, commercially available pyroxyline can also be used as the component (C). Specifically, commercially available pyroxylins include T.I. N. C. Industrial Co. , Ltd. RS 1/32 sec, RS 1/16 sec, RS 1/8 sec, RS 1/8 L sec, RS 1/8 H sec, RS 1/4 sec, RS 1/4 H sec, RS 1/2 sec, RS 1 sec, RS 5-6 sec, RS 10-15 sec, RS 15-20 sec, RS 30-40 sec, RS 60-80 sec, RS 120 sec, RS 150 sec, RS 300 sec , RS 500 sec, RS 800 sec, RS 1200 sec, RS 2000 sec; , RS 7, RS 20, RS 60, RS 120, RS 500, RS 1000, RS 2000, and the like. These may be used individually by 1 type, and may be used in combination of 2 or more type. In the present invention, when pyroxyline is used as component (C), the monohydric alcohol having 1 to 4 carbon atoms inherent in pyroxyline constitutes a part of component (A).

In the film-forming external preparation of the present invention, the content of component (C) is not particularly limited as long as it can form a film on the skin, but for example 3.5 to 14% by weight, preferably 5 to 11% by weight, more preferably 7 to 9.5% by weight.

(D) Glycyrrhetinic Acids The film-forming topical preparation of the present invention contains glycyrrhetinic acids as component (D). By containing the component (D), the skin-forming external preparation is thickened, thereby making it possible to retain a sufficient amount of liquid even with a small brush, and as a result, a sufficient amount can be applied in one application. excellent coatability can be obtained. Glycyrrhizic acids are at least one of glycyrrhizic acid, derivatives thereof, and salts thereof.

Glycyrrhetinic acid is a known drug known to have anti-inflammatory effects, anti-allergic effects, and the like.

The derivative of glycyrrhetinic acid is not particularly limited as long as it is pharmaceutically or cosmetically acceptable. Specific examples include pyridoxine glycyrrhetinate, stearyl glycyrrhetinate, glyceryl glycyrrhetinate, glycyrrhetinate monoglucuronide, and the like. mentioned. These derivatives of glycyrrhetinic acid may be used singly or in combination of two or more.

Salts of glycyrrhetinic acid and/or derivatives thereof are not particularly limited as long as they are pharmaceutically or cosmetically acceptable. Specifically, alkali metal salts such as sodium salts and potassium salts; ammonium salts; etc. These salts may be used singly or in combination of two or more.

In the film-forming preparation for external use of the present invention, one of glycyrrhetic acid, salts of glycyrrhetic acid, derivatives of glycyrrhetic acid, and salts of derivatives of glycyrrhetic acid may be selected and used as the component (D). Well, you may use it in combination of 2 or more types.

Among these components (D), glycyrrhetinic acid is preferred from the viewpoint of obtaining even better coatability.

In the film-forming topical preparation of the present invention, the content of component (D) is not particularly limited, and may be appropriately set according to the thickening effect to be imparted. , preferably 0.05 to 0.8% by weight, more preferably 0.1 to 0.5% by weight.

The ratio of component (D) to component (C) is preferably 0.01 to 0.1 parts by weight of component (D) per 1 part by weight of component (C), from the viewpoint of obtaining even better coating properties. A ratio of 0.015 to 0.08 parts by weight, more preferably 0.03 to 0.06 parts by weight is more preferred.

Other Components The film-forming preparation for external use of the present invention may further contain a solvent such as water, acetone, ethyl methyl ketone, diethyl ether, etc., if necessary, as long as the effects of the present invention are not impaired. However, solvents other than components (A) and (B) may impair the transparency of the film, or may cause the film to become cloudy or gel when it comes in contact with water. When blending a solvent other than the component and component (B), it is necessary to consider such properties. Furthermore, due to its high volatility, diethyl ether requires careful handling during manufacturing due to its flammability. When blending an ether, it is required to consider such properties. The content of the solvent other than the components (A) and (B) in the film-forming external preparation of the present invention is, for example, about 4% by weight or less, preferably about 2% by weight or less.

Furthermore, the film-forming preparation for external use of the present invention may optionally contain a medicinal ingredient other than the component (D) as long as the effects of the present invention are not impaired. Examples of such medicinal ingredients include anti-inflammatory agents, local anesthetics, analgesics, antihistamines, bactericidal agents, antifungal agents, vitamins, moisturizing agents, whitening agents, tissue repair agents, skin protective agents, and keratin softeners. , topical irritants, antipruritic agents, astringents, UV protection agents, silicone gels, crude drug extracts, amino acids, minerals and the like.

In addition, the film-forming preparation for external use of the present invention may optionally contain a thickening agent, a buffering agent, a chelating agent, an antioxidant, and a stabilizing agent other than the component (D), as long as the effects of the present invention are not impaired. Additives such as emulsifiers, plasticizers, preservatives, fragrances, cooling agents, coloring agents, dispersing agents, fluidizing agents, thickening agents, adsorbents, moisturizing agents, wetting agents, moisture-proof agents, antistatic agents, etc. may contain.

Form of formulation The form of formulation of the skin cleanser composition of the present invention is not particularly limited as long as it is a viscous liquid at room temperature, that is, in a semi-solid form (gel or paste). Since the skin cleanser composition of the present invention is effectively thickened, it is possible to hold a sufficient amount of liquid even with a small brush. allow you to have sex.

The specific viscosity of the skin cleanser composition of the present invention is preferably from 5,000 to 15,000 mPa·s, more preferably from 5,500 to 13,000 mPa·s, still more preferably from 6,000 to 11,000 mPa, from the viewpoint of obtaining even better applicability. ·s, particularly preferably 6000 to 8000 mPa·s. Here, the viscosity is a value measured at 20 to 22° C. with a Brookfield viscometer (spindle No. 3, 12 rpm).

Method for producing a film-forming topical preparation The film-forming topical preparation of the present invention is prepared by mixing the components (A) to (D) and, if necessary, other solvents, medicinal ingredients, additives, etc., in desired amounts. Prepared by

Method of Using the Film-Forming Preparation for External Use 1.5 to 4.5 mm in width) and applied to the skin site, it is used as a so-called liquid bandage. The film-forming preparation for external use of the present invention is thickened so that it can hold a sufficient amount of liquid even with a small brush. Brush application is used by applying to suitable skin sites.

Since a sufficient amount of the film-forming preparation for external use of the present invention can be applied to the skin site, a sufficiently thick film is easily formed, thereby protecting the skin site well. .

The skin site to which the film-forming preparation for external use of the present invention is applied may be any skin site suitable for application with a small brush. part. More specifically, skin sites to which the film-forming preparation for external use of the present invention is applied include fingers and toes, more preferably fingers. Fingers in particular move a lot on a daily basis and are easily exposed to various external factors. It is preferable in that the film does not break due to external factors or external factors, and a better protective effect can be obtained.

In addition, the skin site to which the film-forming preparation for external use of the present invention is applied preferably includes a wounded part of the skin. Wounded areas of the skin include cracks, chaps, cuts, punctures, peeling, and other sites where irritation is felt due to thinning or lack of stratum corneum. These sites inevitably experience irritation such as solvent irritation and physical irritation due to the act of application when the film-forming preparation for external use is applied. Since the film-forming preparation for external use of the present invention can be applied in a sufficient amount with one coat, there is no need to repeatedly coat it. In other words, when applied to a wounded part of the skin, it is preferable in that pain can be reduced by minimizing repeated stimulation during application. In particular, the fingers of the hand are not only easily wounded by external factors, but are particularly sensitive to pain at the wound site. Therefore, when applied to a wounded part of a finger, it is more preferable from the viewpoint of reducing pain by minimizing irritation during application.

Container The film-forming preparation for external use of the present invention is contained in a container fitted with a brush designed to have a predetermined size. The container has a container body and a lid portion provided with an applicator member that enters inside the container body. The material of the container body is not particularly limited, and includes metals and resins, but metals are preferable from the viewpoint of the stability of the accommodated formulation. The lid may be configured to be able to seal the opening of the container body. Although the material of the lid is not particularly limited, it is preferably resin from the viewpoint of airtightness.

FIG. 1 shows an example of a lid provided with an application member. As shown in FIG. 1, the lid portion 10 is provided with an application member 20 . The application member 20 has a handle portion 21 and a brush portion 22 provided at an end (one end) of the handle portion 21. The other end of the handle portion 21 is the opening of the container body of the lid portion 10. fixed to the inner wall facing the This allows the application member 20 to enter the container main body when the lid is closed, and the brush portion 22 of the application member 20 is impregnated with the film-forming external preparation inside the container main body.

The brush portion 22 is configured by fixing a bundle of bristles to one end of the handle portion 21 . The tufts of the bristles 22 and the handle 21 may be made of different materials (for example, different resins), and the base of the tufts may be embedded (flocked) in one end of the handle 21 and fixed. The bristle tufts of the brush portion 22 and the handle portion 21 may be integrally molded with resin. The size of the brush portion 22 is such that, in a front view, the length L from the base end (fixed end of the hair bundle) to the tip (free end of the hair bundle) is 11 to 13 mm, and the tip width (free end width of the hair bundle) W1. is designed to be 1.5 to 4.5 mm. Preferably, the length L from the proximal end to the distal end is designed to be 11.5 to 12.5 mm, and the width W1 to the distal end is 1.8 to 4.2 mm. In the present invention, the width W1 of the tip refers to the width of the tip in the dry state in which the bristles do not retain the film-forming preparation for external use. Such a small-sized brush inherently cannot hold a sufficient amount of liquid in one stroke, because the amount of liquid that can be retained is small. However, since the film-forming preparation for external use of the present invention is effectively thickened, even a brush designed with such a small size can retain a sufficient amount of liquid, resulting in , it is possible to obtain excellent applicability in which a sufficient amount can be applied in one coat.

Further, when viewed from the front, the base end width (fixed end width of the bristle bundle) W2 of the brush portion 22 is, for example, 1.5 to 5.5 mm, preferably 2.5 to 5.2 mm. Further, the tip width W1 is preferably configured to be narrower than the base width W2 from the viewpoint of facilitating application to finer parts. Each of the bristles constituting the bristles may be arranged in a line across the base end width W2 of the bristle portion, or may be arranged in a plurality of rows overlapping in the side view direction to determine the total number of bristles. may be increased. From the viewpoint of facilitating application to finer parts, it is more preferable that each of the bristles constituting the bristles is arranged in a line over the base end width W2. Also in this case, since the total number of hairs constituting the hair tuft is small, the amount of liquid that can be held is originally small and a sufficient amount cannot be applied in one application. However, since the film-forming preparation for external use of the present invention is effectively thickened, it retains a sufficient amount of liquid even if the total number of bristles constituting the bristles of the brush portion 22 is small. As a result, it is possible to obtain excellent coating properties that allow a sufficient amount to be coated in one coat.

2. Method for thickening a film-forming external preparation As described above, glycyrrhetinic acids are composed of a monohydric alcohol having 1 to 4 carbon atoms, a monocarboxylic acid having 2 to 4 carbon atoms, and a monohydric alcohol having 1 to 5 carbon atoms. A film-forming preparation for external use containing an ester and nitrocellulose was applied to a container containing the film-forming preparation for external use with a small brush (length from base to tip: 11 to 13 mm, tip width: 1). 0.5 to 4.5 mm), the viscosity can be increased to such an extent that excellent applicability can be obtained. Therefore, the present invention further provides (A) a monohydric alcohol having 1 to 4 carbon atoms, (B) an ester of a monocarboxylic acid having 2 to 4 carbon atoms and a monohydric alcohol having 1 to 5 carbon atoms, and (C ) containing nitrocellulose; housed in a container having a container body and a lid portion provided with an applicator member that enters into the container body, the applicator member being provided at a handle and an end of the handle (D) glycyrrhetin; Provided is a method for thickening a film-forming preparation for external use, which comprises blending an acid, a derivative thereof, and/or a salt thereof.

In the present invention, thickening the film-forming external preparation means that the film-forming external preparation containing components (A), (B), and (C) does not contain component (D). In comparison, it refers to raising the viscosity to such an extent that excellent coating properties can be obtained with a small brush (11 to 13 mm in length from base to tip and 1.5 to 4.5 mm in tip width). As shown in Examples, the viscosity is such that a sufficient amount can be applied in one coat and a thick film is formed. Say.

In the method for increasing the viscosity of the film-forming topical preparation, the type and amount of ingredients used, the form of the film-forming topical preparation, the method of use, etc. are as shown in the section "1. Film-forming topical preparation". is.

EXAMPLES The present invention will be described in more detail with reference to examples below, but the present invention is not limited to these.

Test example 1
[Preparation of film-forming preparation for external use]
A film-forming external preparation having the composition shown in Table 1 was prepared. Specifically, components (A) and (D) are stirred and mixed, and after adding and dispersing component (C), component (B) is added and uniformly stirred and dissolved to form a film. An external preparation was obtained. Pyroxyline was used as nitrocellulose, and preparations were made so that the amount of nitrocellulose in pyroxyline was as shown in the table.

[Measurement of viscosity]
A screw tube SV-50A (outer diameter 40 mm, total height 75 mm, manufactured by Maruem) was filled with 53.3 g of each prepared film-forming topical preparation. Brookfield B type viscometer (LVDV-II+) spindle No. 3 was used to measure the viscosity of each film-forming topical preparation in the screw tube. The measurement conditions were a temperature of 20 to 22° C. and a rotational speed of 12 rpm, and the viscosity was measured 3 minutes after the start of measurement. Table 1 shows the results.

[Evaluation of coatability]
An application member (application member A) having a handle and a brush provided at one end (one end) of the handle was prepared. The size of the brush portion of the coating member A is 12 mm from the base end to the tip (corresponding to the length L in FIG. 1) and 2 mm in the tip width (corresponding to the tip width W1 in FIG. 1) when viewed from the front. , the proximal end width (corresponding to the proximal end width W2 in FIG. 1) is 2 mm. In the application member A, the tufts of the bristles and the handle are made of different resins. It is designed to be fixed in a manner arranged in multiple rows in the direction. The brush portion of the application member was sufficiently impregnated with each film-forming preparation for external use filled in the screw tube.

(Evaluation 1: Coating amount of one coat)
The brush portion of the application member was lifted out of the film-forming preparation for external use, and the preparation was applied to the surface of the membrane in one coat. In addition, one coating means coating by moving the brush part only once in one direction. Each film-forming topical formulation was applied three times in the same manner, and the membrane before and after each application was weighed with an electronic balance for each of the three times, and the difference was averaged to derive the applied amount per application. Table 1 shows the results.

(Evaluation 2: film state of one coat)
The brush portion of the application member was pulled out of the film-forming preparation for external use and applied to the base of the fingernail in one coat. In addition, one coating means coating by moving the brush part only once in one direction. The state of the film after coating was visually observed and judged based on the following criteria. In other words, it was evaluated that the thicker the obtained film, the better the film condition. Table 1 shows the results.
A: A thick film was obtained.
◯: A slightly thick film was obtained.
Δ: Only a thin film was obtained.
x: A film was not obtained.

As is clear from Table 1, the film-forming external preparation containing components (A), (B) and (C) (Comparative Example 1) did not contain nitrocellulose as a film component (Comparative Example 3). However, at such a degree of viscosity increase, it was not possible to obtain such excellent applicability that a sufficient amount could be applied in one coat with a brush of a small size. On the other hand, in the film-forming external preparations (Examples 1 and 2) in which glycyrrhetinic acid, which is the component (D), was added to the components (A), (B), and (C), glycyrrhetinic acid itself was Despite not being a thickening component (Comparative Example 2), a remarkable thickening effect was observed. As a result, a remarkable increase in the coating amount per coat was observed, and a remarkable improvement in the state of the film was also observed.

Test example 2
The applicability was evaluated in the same manner as in Test Example 1, except that the applicator member B was used instead of the applicator member A. The size of the brush portion of the coating member B is 12 mm from the base end to the tip (corresponding to the length L in FIG. 1) and 4 mm in the tip width (corresponding to the tip width W1 in FIG. 1) when viewed from the front. , the proximal end width (corresponding to the proximal end width W2 in FIG. 1) is 5 mm. The application member B is designed so that the tufts and the handle are integrally molded with resin, and the bristles forming the tufts are arranged in a line across the width of the base end of the bristles. According to the film-forming preparations for external use of Examples 1 and 2, a marked increase in the amount applied per coat was observed, and a marked improvement in the state of the film was also observed.

Claims (5)

(A) C1-4 monohydric alcohols, (B) esters of C2-4 monocarboxylic acids and C1-5 monohydric alcohols, (C) nitrocellulose, and (D) glycyrrhetin acid, pyridoxine glycyrrhetinate, stearyl glycyrrhetinate, glyceryl glycyrrhetinate, glycyrrhetinate monoglucuronide , and/or salts thereof ;
It is housed in a container having a container body and a lid portion provided with an application member that enters into the container body, and the application member has a handle and a brush provided at the end of the handle. and a film-forming external preparation (6 to 13 weight % of the component (C) and 5 to 15% by weight of vegetable oil, and the weight ratio of the vegetable oil to the component (C) is 0.8 to 1.5). 2. The film-forming preparation for external use according to claim 1, which is used for application to fingers. 3. The film-forming preparation for external use according to claim 1 or 2, which is used for application to wounds on the skin. The film-forming preparation for external use according to any one of claims 1 to 3, which has a viscosity of 5,000 to 15,000 mPa·s. (A) a monohydric alcohol having 1 to 4 carbon atoms, (B) an ester of a monocarboxylic acid having 2 to 4 carbon atoms and a monohydric alcohol having 1 to 5 carbon atoms, and (C) nitrocellulose,
It is housed in a container having a container body and a lid portion provided with an application member that enters into the container body, and the application member has a handle and a brush provided at the end of the handle. and a film-forming external preparation having a length of 11 to 13 mm from the base end to the tip of the brush and a width of the tip of 1.5 to 4.5 mm (provided that 6 to 13% by weight of the (C) component and 5 to 15% by weight of vegetable oil, and the vegetable oil/(C) component weight ratio is 0.8 to 1.5),
(D) A method for thickening a film-forming external preparation, which comprises blending glycyrrhetinic acid, pyridoxine glycyrrhetinate, stearyl glycyrrhetinate, glyceryl glycyrrhetinate, monoglucuronide glycyrrhetinate , and/or salts thereof .

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