JP2017057146A - Anti-pro-oxidant/glyceryl octyl ascorbic acid derivative and its preparation and use - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide an anti-pro-oxidant glucosyl octyl ascorbic acid derivative and preparation and use thereof.SOLUTION: An ascorbic acid derivative is realized which has high safety and high physiological activity in which the ascorbic acid radical generation is reduced to suppress the pro-oxidant effect by producing high purity glucosyl octyl ascorbic acid. Furthermore, by the suppression of pro-oxidant effect, the changes in the product with time can be suppressed and the durability can be improved, and the invention can be applied to a wide range of products.SELECTED DRAWING: None

Description

 The present invention relates to a production method, effect, and use of a high-purity glyceryl octyl ascorbic acid derivative (hereinafter referred to as Gly-Oct-ASA) with an enhanced anti-oxidation effect that is unlikely to become a prooxidant with suppressed generation of ascorbic acid radicals. .

L-ascorbine (hereinafter referred to as ASA) is one of the important vitamins for humans. Humans, primates, and guinea pigs are essential vitamins because they cannot synthesize vitamin C in the body. For this reason, many ASAs and their derivatives are used in the fields of medicine, quasi-drugs, unapproved medicines, feeds, cosmetics, and foods as supplements for vitamin C sources. Furthermore, ASA has a strong reducing action, so it is widely used as an antioxidant in chemical products, industrial products, miscellaneous goods, clothing and the like.

 On the other hand, it is known that most antioxidant substances such as ASA change to substances that promote oxidation when the partner is reduced. Substances that produce oxidants are called prooxidants. When oxidized, ASA may turn into a free radical called the ASA radical, which strongly oxidizes the partner. The ASA radical is a type of prooxidant.

 Regarding the harmful effects of prooxidants, prooxidants may be neurodegenerative disorders, peroxisome disorders, Zerberger syndrome, neonatal adrenoleukodystrophy, lefsum disease in infants, hyperpepecolic acidemia, punctate epiphyseal abnormalities, Zerberger-like Syndrome, adrenoleukodystrophy, adrenal spinal neuropathy, acyl-CoA oxidase deficiency, bifunctional protein deficiency, thiolase deficiency, type I hyperoxaluria, acatalaseemia, adult lefsum, Alzheimer's disease, Huntington's disease, schizophrenia That the human body is affected by various disorders such as diabetes and diabetic neuropathy, and that vitamin E derivatives with prooxidants exert the toxicity of killing cancer cells. Furthermore, it is also known that ASA becomes a prooxidant that generates free radicals such as ASA radicals, and Non-patent document 1 that ASA radicals are a kind of active oxygen and can be analyzed using ESR. ing.

 Hydroxy radicals are generated when hydrogen peroxide reacts with iron. This is called the Fenton reaction. The Fenton reaction is one of the most powerful oxidation reactions. This reaction occurs in an aqueous solution, air, plastic resin, and rubber. Ultraviolet rays and radiation react with a small amount of water to generate hydrogen peroxide. At the same time, if there is an iron compound or the like, the Fenton reaction takes place and water is decomposed to generate active oxygen. It occurs when it reacts with a protein containing a transition metal such as iron (hereinafter simply referred to as a metal protein) in vivo. Non-patent document 2 in which oxidized iron is recycled and induces a strong oxidation reaction when ASA is involved.

 At this time, a large amount of ASA radicals, hydroxy radicals, superoxide, hydrogen radicals, hydrogen peroxide, etc. are generated. Hydrogen peroxide in the living body is frequently provided by intracellular mitochondria, exposure to neutrophils and ultraviolet rays, drug reactions, foods, and the like. Transition metals such as iron and copper are brought in large quantities in vivo by metalloproteins such as hemoglobin and cytochrome. The Fenton reaction induced by these substances is enhanced by ASA, resulting in the generation of a large amount of ASA radicals, and this prooxidant produces a larger amount of active oxygen, eventually killing the cell and causing tissue damage. If this lasts for a long time, it accelerates aging and causes radical calculosis.

 When the skin tissue is irradiated with a certain amount of ultraviolet rays, erythema occurs on the skin surface. Erythema refers to a condition in which the surface of a tissue such as skin becomes red due to expansion of capillaries and the like, and is a form of tissue damage such as inflammation. Vasodilation. The generation of active oxygen such as NO radicals, superoxide, ASA radicals is involved by neutrophil infiltration. If erythema is accompanied by arterial dilatation, the skin temperature rises and the amount of active oxygen in the skin increases. Erythema disappears when pressed, whereas purpura and pigmentation do not disappear when pressed and are clearly different. Causes of erythema are physical damage such as UV radiation damage, infections (fungi, mycoplasma, viruses, etc.), burns, acne, allergies, massage, electrical treatment, excessive exercise, radiation damage, hair pulling, and surfactants. And chemical reactions with drugs. There are many types of erythema such as nodular erythema, infectious erythema and polymorphic exudative erythema. For nodular erythema, infectious diseases such as bacteria, viruses, and fungi, and underlying diseases (such as Behcet's disease, tuberculosis, sarcoidosis, Crohn's disease), visceral malignant tumors, drugs, drugs such as sulfa antibiotics and oral contraceptives There is something by.

 A radical disease is a disease associated with free radicals, such as myocardial infarction, ischemic heart disease, heart failure, angina, arrhythmia, arteriosclerosis, liver lipid metabolism disorder, hyperlipidemia, essential hypertension. Hypertension, arteriosclerosis, coronary atherosclerosis, thrombosis, obstructive arteriosclerosis, vascular disorder, peripheral vascular disorder, cholestasis, hypercholesterolemia, pancreatic disorder, organ failure, acute chronic hepatitis, gastric ulcer, Duodenal ulcer, ulcerative colitis, digestive organ disorder, cholecystosis, diabetes, arthritis treatment, rheumatism, liver failure, liver disorder, ischemic liver disorder, liver lipid metabolism disorder, gallbladder disorder, organ transplant disorder, diabetes mellitus, addiction , Organ transplantation disorder, ischemic reperfusion injury and the like. It is described in the book of a nonpatent literature 3, a nonpatent literature 4, and a nonpatent literature 5 that these diseases are radical diseases. The above literature also describes that ASA is effective for these diseases. Further, L-ASA-2- (poly) phosphoric acid is effective for these diseases as disclosed in Patent Document 5 and the like according to the previous invention of the present inventor. Furthermore, it has been clarified in the study of the inventors of Non-Patent Document 6 that ASA-2-phosphate Na and tocopheryl phosphate Na are effective against oxidative damage in the brain caused by drugs. .

 By the way, these ASA derivatives such as ASA-2-phosphoric acid are analyzed by the integrated value of photon absorption accompanying the absorption of a specific ultraviolet wavelength of ASA by an analysis method using high performance liquid chromatograph (hereinafter, HPLC). Concentration and purity can be measured quantitatively.

 ASA can donate more electrons and reduce iron by changing to ASA hydrodeoxy ASA (DHA), which is oxidized vitamin C. The presence of one molecule of ASA makes it possible to reduce iron twice, that is, theoretically three times as much iron can be used as compared to the case where ASA is not present. ASA has hydroxyl groups at the 2nd and 3rd positions of carbon, but these two hydroxyl groups are oxidized to form double bonds of oxygen to form dehydroASA. Therefore, when oxygen at the 2-position and 3-position of ASA is protected by an ester bond or the like, the oxidation-reduction reaction center disappears, so that it becomes extremely difficult for ASA to donate electrons, and the oxidation-reduction reaction hardly occurs. This state is called ASA stabilization by ASA derivatives. Because ASA has two reaction centers, the stability is increased by blocking two reaction centers compared to blocking one. If ASA is present in excess, theoretically, this reaction is recycled and continues until ASA becomes dehydroASA, so if an oxidation reaction involving ASA occurs in vivo, the damage to cells and tissues is Become serious.

 Already known ASA-2-phosphate salts, Patent Document 1, Glucopyranosyl ascorbic acid, Patent Document 2, Hydroxypropyl phosphate ascorbate, Patent Document 3, Satsuro Ascorbic acid derivative, Patent Document 4, Ascorbic acid tetra fatty acid ester derivative, Patent Literature 5, aminoascorbic acid derivative, Patent Literature 6, higher fatty acid ester of ascorbic acid-2-phosphate, Patent Literature 7, L-ascorbic acid-2-O-maleic acid -Α-tocopherol diester, Patent Document 8, L-ascorbic acid-2-O-phosphate-α-tocopherol diester, Patent Document 9 are both esterified at the 2-position or 3-position of ASA Therefore, even if it becomes an ASA derivative, the electron donating power for one electron remains. For this reason, when an enzyme containing iron or copper such as hemoglobin reacts with hydrogen peroxide to cause an oxidation reaction, the presence of an ASA derivative that is not esterified at the 2- or 3-position enhances the oxidation reaction. Is done. The ASA radical generated at this time can be detected by a free radical detector.

 The most accurate method for measuring ASA radicals in tissues is a detection method using an apparatus called electron spin resonance (hereinafter referred to as ESR) or electron paramagnetic resonance (EPR). This ESR is called a spin trapping agent such as 5,5-dimethyl-1-pyrroline-N-oxide (DMPO), 5- (dipropoxyphosphoric acid) -5-methyl-1-pyrroline N-oxide (DPPMPO). The signal is stabilized using a reagent that stabilizes unpaired electrons of the free radical, and the peak of the free radical spectrum is detected. Furthermore, it is possible to make a comparative quantitative comparison of the amount of free radicals generated from the peak height and width of the ESR spectrum. For this reason, not only ASA radicals, but also hydroxyl radicals, superoxide, hydrogen radicals, methyl radicals, etc. can be quantified simultaneously. Non-patent document 6 discloses a method capable of sensitively detecting active oxygen from tissues by ESR studies published by the present inventors.

 In ASA derivatives known from Patent Documents 1-9, etc., either the 2-position or 3-position of ASA is in a free state in which the ASA is in a free state. To induce oxidative damage. As a side effect of ASA, this is considered to be one of the causes of cell death or exacerbation of ASA-derived allergies and allergic contact dermatitis, Non-Patent Documents 7-10, which have been rapidly reported in recent years. .

 There is also a report that promotes an oxidative reaction in a large dose of ASA, induces cell death of cancer cells, and exerts an effect as an anticancer agent. Furthermore, ASA and its derivatives have been added to cosmetics to improve wrinkles and acne, but it has been pointed out that active oxygen is one of the causes of wrinkles and acne. Therefore, increasing the stability and antioxidant capacity of conventional ASA and its derivatives is considered to facilitate these solutions, but at the same time, it is extremely difficult to suppress the transition of conventional ASA and its derivatives to prooxidants. It can be one of the solutions for important wrinkles and acne. In other words, if the ASA radicals generated by existing ASA derivatives can be suppressed, it can be considered to contribute to the improvement of wrinkles and acne. However, until now, no technology has been developed for suppressing ASA radicals generated by existing ASA derivatives. Furthermore, this has not led to improvement of wrinkles and acne.

 Conventional ASA derivatives such as ASA phosphates have been reported to be less prooxidant and do not generate ASA radicals. However, it does not occur completely, and in particular, a large amount of free radicals such as in vivo Fenton reaction are generated locally due to superoxide-producing tissues such as ultraviolet rays and neutrophil infiltrating inflammatory tissues and bleeding and hemolysis. In the case of an amphiphilic ASA derivative or when the concentration of ASA in the tissue becomes high due to ion introduction or the like, an ASA radical is generated even if the ASA derivative is protected at the 2-position or 3-position. In some cases, the present inventors have found that this is the case.

This is because most ASA derivatives retain the reducing action even when they are not hydrolyzed enzymatically and act as reducing agents. That is, after exerting the reducing action, it is considered that the ASA ester is easily hydrolyzed non-enzymatically, and is non-enzymatically oxidatively decomposed to become ASA radicals to act as a prooxidant.
Recently, the present inventors have disclosed 2-O-glyceryl-3-octyl ASA (hereinafter abbreviated as 2-G-3-O-ASA) and 2-O-octyl-3-O-glyceryl ascorbine according to claim 3. Invented glyceryl octyl ASA (hereinafter abbreviated as Gly-Oct-ASA), including acid (hereinafter abbreviated as 2-O-3-G-ASA) and Patent Document 10.

 Since these Gly-Oct-ASAs were chemically modified at the 2nd and 3rd positions at the same time and blocked, it was expected that the electron donation reaction of ASA would hardly occur. Actually, however, contrary to expectations, the ASA radical was measured in a Fenton reaction system with hemoglobin, and as a result, the occurrence of the same level as that of a conventional ASA derivative in which either one of the 2-position and the 3-position was not chemically modified was observed.

 Since 2-G-3-O-ASA and 2-O-3-G-ASA described in Patent Document 10 are amphiphilic ASA derivatives, they are more permeable to skin than ordinary water-soluble ASA derivatives. Therefore, even if the amount is small, the ASA concentration in the skin can be increased. On the other hand, if the ASA concentration is rapidly increased, ASA radicals are generated and there is a risk of causing side effects. However, in fact, because the speed of 2-G-3-O-ASA and 2-O-3-G-ASA being converted to ASA is slow, the sustained release is sufficient and the permeability is high. Radical production is kept low. However, ASA and the like contained as impurities are problematic because they are promptly converted into ASA radicals.

 In tissues with high hydrogen peroxide levels, such as neutrophil-concentrated tissues under inflammation and skin irradiated with ultraviolet rays, the Fenton reaction by iron protein and ASA is recycled, which is lower than conventional ASA. The same level of ASA radical elevation and cell damage was observed. That is, the recycle oxidation reaction suppression effect expected by blocking both the 2nd and 3rd positions was not obtained.

 When Gly-Oct-ASA, which is already sold as a product, was examined in detail, it was found that the pH was quite acidic, even though ASA 2 and 3 were blocked. This is because either Gly-Oct-ASA, which is supposed to be blocked, is in a free form in which either position 2 or 3 is not chemically modified, or another ASA derivative that liberates hydrogen. Was expected to be contained as a by-product impurity. That is, it means that there may be ASA derivatives that are free in either one or both of the 2-position and 3-position of the ASA derivative.

 We performed high-performance liquid chromatography to analyze the conventional Gly-Oct-ASA that has already been sold as a product. As a result, impurities such as 10 or more types of by-products could be confirmed from the conventional Gly-Oct-ASA. In particular, it was confirmed that substantial amounts of ASA and monoglyceryl ASA remained as impurities that could be quantified. It was considered that this was an unreacted substance during the synthesis reaction, or a part of the synthesized product was hydrolyzed by an equilibrium reaction.

 Examples of ASA derivatives that can be considered as monoglyceryl ASA of impurities include one or more selected from 2-monoglyceryl ASA, 3-monoglyceryl ASA, 6-monoglyceryl ASA, and 5-monoglyceryl ASA.

 As ASA derivatives which are free as the 2nd and 3rd positions contained as impurities, the following may be synthesized due to the ease of the reaction. 2-monoglyceryl-6-octyl ASA, 2-monoglyceryl-5-octyl ASA, 3-monoglyceryl-6-octyl ASA, 3-monoglyceryl-5-octyl ASA, 2,6-diglyceryl-6-octyl ASA 1 or more selected from 6-monoglyceryl-2-octyl ASA and 6-monoglyceryl-3-octyl ASA. Of these, the most likely impurities are unreacted ASA and non-octylated monoglyceryl ASA. As a result of identification by HPLC (HPLC), the present inventors contained the most of these two compounds in the conventional Gly-Oct-ASA.

 By the way, the lamellar liquid crystal or vesicle structure has a multi-layered structure like a sandwich of water-lipid-water-lipid-water ... regularly and alternately as seen in the lipids between skin cells. This thin crystal plane structure is called lamellar liquid crystal (lamella structure, vesicle liquid crystal). When emulsified particles with this lamellar liquid crystal structure are observed under a polarizing microscope crossed Nicol, an image of a typical negative spherulite (the slow axis [molecular chain direction] of the refractive index ellipsoid is perpendicular to the radial direction of the spherulite) appears. The resulting image is called a Maltese cross (cross-shaped shadow). The presence of the lamellar liquid crystal can be confirmed by confirming the Maltese cross image. Since this lamellar liquid crystal structure is similar to lipids between skin cells, it has been reported that emulsified fine particles having this structure are easily absorbed into the skin. The present inventors have found that an emulsified composition of an amphiphilic ASA derivative having such a multilayer structure has improved stability and skin absorbability, and has already made known from Patent Document 11 and Patent Document 12.

 Humans, primates, guinea pigs, and fish cannot synthesize vitamin C in the body, and can be further synthesized in cattle, pigs, chickens, horses, dogs, cats, etc., infectious diseases, etc. As a result, the activation of neutrophil activity increases vitamin C consumption, the amount of ASA radicals may increase, and the amount of normal biosynthesis may be insufficient. During this period, vitamin C supplementation from outside is effective. It is known.

 In addition, it is known that the amount of active oxygen in the living body rises rapidly when the environmental temperature rises, such as high temperature stress, and phenomena such as liver oxidation and increase of lipid peroxides in the body are observed, and ASA radicals increase. Has been reported. In such cases, overdose of ASA is counterproductive and requires ASA derivatives that do not generate ASA radicals.

In addition, many ASAs and their derivatives are used in the fields of medicine, feed, cosmetics, foods, animal drugs, culture drugs, and the like. Development of a formulation is desired.

 On the other hand, resin products, building materials, photosensitive materials, paints, industrial goods, civil engineering greening supplies, fertilizers, paints, cleaning materials, agricultural and forestry supplies, horticultural supplies, powder products, miscellaneous goods, clothing, feed, food, culture ASA is also used as an antioxidant in the fields of compositions, veterinary drugs, miscellaneous goods, bandages, sports tapes, bandages, clothing, socks, gloves, masks, photosensitizers, water treatment agents, air purification agents, etc. However, these products are often used for a long time in an ultraviolet irradiation environment. Furthermore, in the fields of water treatment agents, air purification agents, cleaning agents, etc., sulfur oxides and nitrogen oxides in water and air In addition, since it contains strong radical generating particles such as metal compound fine particles, it is often a harsh oxidizing environment, and long-term exposure to active oxygen may lead to deterioration or destruction of the product. The products in these fields also generate a large amount of hydroxy radicals, superoxide, and ASA, so ASA administration may cause a situation where ASA radicals are generated and oxidation is further promoted. There is a strong demand for the use of ASA derivatives that do not generate ASA radicals.

 When these products are exposed to sunlight for a long time, active oxygen is generated in the products. In addition, even if it is not exposed to sunlight, due to the influence of oxygen in the air, part of it changes to active oxygen, the molecules that make up the product are naturally oxidized by the influence of these active oxygen, and the molecules in the product are cut, It causes peeling, deterioration, cracking, cutting, perforation, and component decomposition. In these products, ASA and its derivatives have been added as antioxidants to eliminate active acids, but conventional ASA and its derivatives have generated ASA radicals, and their effects could not be fully demonstrated. Tocopherol, its derivatives, BHT, etc. have been added to the product, but none of them produced prooxidants and could not obtain sufficient effects.

 As a result of analysis using HPLC, the existing Gly-Oct-ASA contains at least 3% by weight of ASA and monoglyceryl ASA, and other unknown impurities remain at 5% or more by HPLC area ratio. Was confirmed.

   These impurities are free forms in which ASA 2 and / or 3 are not sequestered, so iron is recycled during the Fenton reaction involving iron, hemoglobin, etc., and the Fenton reaction Has been found to promote oxidation and generate ASA radicals. In particular, in tissues with high hydrogen peroxide levels such as inflamed neutrophil infiltrating tissues and skin irradiated with ultraviolet rays, it was found from the ESR measurement results and the progress of inflammation that cell damage was enhanced.

Japanese Patent Application No. 2001-554443 Patent 2832848 Japanese Patent Application No. 3-250458 Japanese Patent Application No. 3-178342 Japanese Patent Application No. 5-61364 Japanese Patent Application No. 6-13667 Japanese Patent Application No. 2004-352913 Patent 4179809 Japanese Patent Application No. 2000-580631 Japanese Patent Application No. 2009-529057 Japanese Patent Application No. 2011-219440 Japanese Patent Application No. 2005-380887

Galley HF, Davies MJ, Webster NR. Free Radic Biol Med. 20 (1): 139-43, 1996 Burkitt MJ, Gilbert BC. Free Radic Res Commun. 1990; 10 (4-5): 265-80. "Reactive oxygen and pathology" edited by Inoue, Academic Publishing Center, 1992 "Antioxidants", Futaki et al., Academic Publishing Center, 1994 “Contemporary Medicine” vol. 25, no. 10, 1993 S. Ito, et al., Toxicology. 30; 240 (1-2): 96-110. 2007 Assier H, et. Al., Contact Dermatitis. 2014 Jul; 71 (1): 60-1. Yagami A, et. Al., Contact Dermatitis. 2014 Jun; 70 (6): 376-7. Belhadjali H, et. Al., Contact Dermatitis. 2001 Nov; 45 (5): 317. Venturelli S, et. Al., Wien Med Wochenschr. 2015 Jun; 165 (11-12): 251-257.

The problem to be solved by the present invention is to remove these ASA and monoglyceryl ASA, which are impurities that generate ASA radicals, from conventional Gly-Oct-ASA that has already been sold, or to reduce the concentration thereof. To provide ASA derivatives that suppress the generation of ASA-induced impurities, suppress the recycling Fenton reaction, significantly reduce the negative effects of active oxygen compared to conventional ASA derivatives, and maximize the antioxidant effect There is.

 Furthermore, it is to provide an external composition, an oral composition, and products having an excellent effect by utilizing the effect obtained from the ASA derivative that can exhibit the antioxidant effect to the maximum.

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塩化ナトリウムとりん酸水素二ナトリウムを含む溶液中で、標準のアスコルビン酸叉は標準と同モルの本発明のGly-Oct-ASAとヘモグロビンと過酸化水素を添加してフェントン反応させ、スピントラップ剤を使用して電子スピン共鳴分光計でアスコルビン酸ラジカル強度をピークの高さとして測定するとき、Gly-Oct-ASAのアスコルビン酸ラジカル強度が、同モルのアスコルビン酸の発生するアスコルビン酸ラジカル強度の５０％以下である請求項１の高純度Gly-Oct-ASA
［５］
２-G-３-O-ASAと３-オクチル-ASAの共存下で、酸性条件下で３-オクチルASAを加水分解処理する工程と溶媒による抽出法とカラムクロマトグラフィー分離抽出法の中から選択される一種以上の抽出法を組み合わせる請求項１の高純度２−o-グリセリル−３-オクチルASAの製造方法
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２-O-３-G-ASAと３-グリセリルアスコルビン酸の共存下で、酸性条件下で３−o-グリセリルアスコルビン酸を加水分解処理する工程と溶媒による抽出法とカラムクロマトグラフィー分離抽出法の中から選択される一種以上の抽出法を組み合わせる請求項１の高純度２−o-オクチル−３-O-グリセリルアスコルビン酸の製造方法
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乳酸デヒドロゲナーゼ、リンゴ酸デヒドロゲナーゼ、アスパラギン酸アミノ基転移酵素、ストレスプトテインの値を改善し、抗脂質代謝改善作用と肝機能改善作用と抗体ストレス作用を有する、アスコルビン酸ラジカル発生が抑制された、アスコルビン酸源として請求項１の高純度Gly-Oct-ASAを含む、経口用組成物。
［８］
経口用組成物、体内用組成物、化成品から選ばれる何れかである、アスコルビン酸源として請求項１の高純度Gly-Oct-ASAを含む組成物。
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医薬品、医薬部外品、医療用培養薬品、医療機器、医療用具、未承認医薬品、化粧品、動物用化粧品から選ばれる何れかである、アスコルビン酸源として請求項１の高純度Gly-Oct-ASAを含む、アスコルビン酸ラジカル発生が抑制された、外用組成物。
［１０］
以下の商品形態からから選ばれる何れかである、請求項８の外用組成物
商品形態としては、アイシャドー、アイブロー、アイライナー、インセクトリペラー、ウォーターグリース、ウォッシングパック、エッセンス、エナメルリムーバー、エモリエントクリーム、エモリエントローション、エルボーローション、オイルシャンプー、オイルパック、オーデコロン、オードトワレ、オードパルファム、カラーローション、クリーム、クリームシャンプー、クレンジングオイル、クレンジングクリーム、クレンジングジェル、クレンジングフォーム、クレンジングマスク、クレンジングミルク、クレンジングローション、コンディショニングシャンプー、サンスクリーン、サンスクリーンクリーム、サンタンクリーム、サンプロテクター、サンプロテクト、シェービングクリーム、ジェル、シャンプー、スキンモイスチャー、香水、ストレートパーマ剤、セットローション、チック、デオドラントクリーム、デオドラントスティック、デオドラントスプレー、デオドラントパウダー、デオドラントローション、トナー、トリートメント、ナイトクリーム、ナリシングクリーム、ナリシングミルク、ナリシングローション、ネイルエナメル、ネイルトリートメント、パーマアフタートリートメント、パーマネントウェーブ、パーマプレトリートメント、バスオイル、パック、バニシングクリーム、パフューム、パルファム、ハンドローション、ピールオフパック、ファンデーション、プレメーキャップクリーム、プロテクトエマルション、ヘアオイル、ヘアカラーアフタートリートメント、ヘアカラープレトリートメント、ヘアクリーム、ヘアジェル、ヘアスプレー、ヘアトニック、ヘアパック、ヘアフォーム、ヘアブリーチ、ヘアブロー、ヘアマニキュア、ヘアミスト、ムース、ヘアリキッド、ヘアワックス、ベースクリーム、ボディーパウダー、ボディシャンプー、ボディスキン用剤、ボディローション、ポマード、マスカラ、マッサージクリーム、マニュキュア、マッサージローション、ミルキィーローション、ミルク、ミスト、蒸気、メーキャップクリーム、メーキャップローション、メーキャップ剤、モイスチャークリーム、モイスチャージェル、モイスチャーローション、モイスャーエマルション、リップグロス、リニメント剤、リポソーム化粧水、リポソーム美容液、リンス、リンスシャンプー、ローション、ローション剤、育毛剤、液状石鹸、化粧下地、化粧水、化粧石鹸、角質スムーザー、角質軟化クリーム、口紅類、香水石鹸、合成化粧石鹸、酸化染毛剤、紫外線防止エッセンス、除毛クリーム、石鹸、洗顔パウダー、洗顔料、洗浄剤、洗粉、脱色剤、脱毛・除毛剤、虫よけスプレー、貼付剤、透明石鹸、軟膏剤、乳液、白粉・打粉類、眉墨、美白エッセンス、粉末パック、保湿エッセンス、芳香パウダー、芳香剤、防臭化粧料、頬紅類、毛髪コート剤、薬用石鹸、浴用剤、シャワー剤、練香水、マスク、靴下、手袋、耳栓、帽子、キャップ、靴下、下着、タイツ、コンドーム、タンポン、ナプキン、指輪、腕輪、首輪、足輪、イヤリング、包帯、絆創膏、ガーゼ、布、縫合糸、皮膚用テープ、皮膚用フィルム、皮膚用接着剤、皮膚用ホッチキス、油取り紙、皮膚用紙、皮膚用クリップ、皮膚用フィルム、皮膚用リボン、皮膚用ペイント、皮膚用不織布、皮膚用紐、皮膚用糸、皮膚用チューブ、皮膚用パッチテスト用キット
［１１］
皮膚の角層水分量の改善作用、表皮水分蒸散量の改善作用、接触性皮膚炎の改善作用、紅斑の改善作用、アクネの改善作用、病原性皮膚常在微生物抑制作用、褥瘡の改善作用からから選ばれる何れかの改善作用を有する、請求項８の外用組成物
［１２］
温度を４０℃±２℃、湿度を７５％RH±５％RHとして６ヵ月間保存する長期高温状態での加速試験における、色調、臭気の安定性が優れた、アスコルビン酸源として請求項１の高純度Gly-Oct-ASAを含む、アスコルビン酸ラジカル発生の抑制された、請求項８の外用組成物
［１３］
請求項１の高純度Gly-Oct-ASAを含有するラメラ液晶を持つ乳化組成物
［１４］
美白作用、フリーラジカル抑制作用、抗シワ作用、抗ニキビ作用、保湿作用、バリア機能増強作用、紫外線由来炎症抑制作用、抗褥瘡作作用からから選ばれる何れかの作用を有する、請求項１３の乳化組成物
［１５］
以下記載のA群の増粘性高分子の一種以上からなる増粘性高分子グループと、以下記載の増粘乳化組成物グループの、２グループの増粘物質の中から選択される、単体叉は複数の物質からなる増粘組成物と、アスコルビン酸源として請求項１のGly-Oct-ASAと、以下記載のD群から選択される抗酸化物、E群から選択される紫外線吸収遮蔽剤、F群から選択される菌増殖抑制物質、G群から選択されるｐH調整物質から選択される粘度安定化物質を一種以上含むことにより、増粘物質の粘度を安定化させた、請求項８の外用組成物
（増粘乳化組成物グループ）
以下のB群の油剤一種以上と、C群の界面活性剤一種以上と、水の三要素からなる増粘乳化組成物
A群：増粘性高分子
（アクリル酸アルキル／ジアセトンアクリルアミド）コポリマー、（アクリル酸アルキル／ジアセトンアクリルアミド）コポリマーAMP、（アクリレーツ／アクリル酸ステアリル／メタクリル酸エチルアミンオキシド）コポリマー、（ジメチコン／ビニルジメチコン）クロスポリマー、（メタ）アクリル酸アルキルエステルの共重合体は、（メタクリロイルオキシエチルカルボキシベタイン／メタクリル酸アルキル）コポリマー、１，２−ブタンジオール、１，２−プロパンジオール、１，２−ヘキサンジオール、１，２−ペンタンジオール、１，２，３−ヘキサントリオール、１，２，３−ペンタントリオール、１,２−ヒドロキシステアリン酸、１，３−ブタンジオール、１，３−ブチレングリコール、１，３−プロパンジオール、１，３−ヘキサンジオール、１，３−ペンタンジオール、１，３，４−ヘキサントリオール、１，３，４−ペンタントリオール、１，３，５−ヘキサントリオール、１，３，５−ペンタントリオール、１,３−ブチレングリコール、１,３−プロパンジオール、１，４−ブタンジオール、１，４−ヘキサンジオール、１，４−ペンタンジオール、１，４，６−ヘキサントリオール、１，５−ヘキサンジオール、１，５−ペンタンジオール、１，６−ヘキサンジオール、２−アミノ−２−メチル−１，３−プロパンジオール、２−エチル−１，３−ヘキサンジオール、２−エチルヘキシルアクリレート、２，３，４−ペンタントリオール、２−エチルヘキシルアクリレート、２−エチルヘキシルメタクリレート、２−ハイドロキシエチル（メタ）アクリレート、２−メチル−１,３−プロパンジオール、３−メチル−１,３−ブタンジオール、EVA・PVC・グラフト共重合体、n−オクチルアクリレート、N−ラウロイル−L−グルタミン酸、PGA−PLA系高分子、α−メチルスチレン、β−アラニン、β−グルカン、アイオノマー樹脂、アクリル−シリコーングラフト共重合体等のシリコーン系各種共重合体、アクリルアミド、アクリル系エラストマー、アクリル酸、アクリル酸−２−エチルヘキシル・メタクリル酸−２−エチルヘキシル・メタクリル酸ドデシル共重合体、アクリル酸・カチオン化メタアクリル酸アミド共重合体、アクリル酸・カチオン化メタアクリル酸エステル共重合体、アクリル酸・メタアクリル酸アルキル共重合体、アクリル酸・メタアクリル酸エステル共重合体、アクリル酸アルキルエステル、アクリル酸メチル・アクリル酸−２−エチルヘキシル共重合樹脂エマルジョン、アクリル樹脂アルカノールアミン、アクリル樹脂エマルジョン、アクリロニトリル、アクリロニトリル−ブタジエンゴム、アシル化ペプチド、アシル化ペプチド等の蛋白ペプチド、アスパラギン、アスパラギン酸、アテロコラーゲン、アミンアイオノマー、アラニン、アラビアガム、アラビトール、アラビノース、アラビノガラクタン、アルギニン、アルギン酸、アルギン酸ナトリウム、アルギン酸プロピレングリコールエステル、アルブミン、アロエ抽出物、イザヨイバラエキス、イソオクチルアクリレート、イソオクチルメタクリレート、イソデシルアクリレート、イソデシルメタクリレート、イソノニルアクリレート、イソブチルアクリレート、イソブチルメタクリレート、イソペンタンジオール、イソロイシン、イノシトール、ウレタン系エラストマー、エアラスチン、エチルグルコシド、エチルセルロース、エチルメタクリレート、エチレン、エチレン−α−オレフィン共重合体、エチレン−アクリル酸エチル共重合体、エチレン−ビニルスルホン酸共重合体アイオノマー、エチレン−メタクリル酸共重合体アイオノマー、エチレン−酢酸ビニル共重合体、エチレン―アクリル酸共重合体アイオノマー、エチレングリコール、エチレングリコール・プロピレングリコール共重合体、エチレングリコールモノエチルエーテル、エチレングリコールモノブチルエーテル、エトキシメチルアクリルアミド等のアルキルエチルメタノール（メタ）アクリルアミド、エラスチン、エラスチン分解ペプチド、エリスリトール、オクチルアクリレート、オクテニルコハク酸トウモロコシデンプンアルミニウム、カードラン、カゼイン、カゼイン分解ペプチド、カチオンポリマー、カチオン化オリゴ糖、カチオン化デキストラン、カッソウエキス、ガム類、カモミラエキス、カラギーナン、カラギーナンガム、ガラクタン、ガラクチトール、ガラクトース、ガラクトマンナン、カラヤガム、カルボキシビニルポリマー、カルボキシメチルセルロース及びそのナトリウム等の塩、カルボキシメチルデンプン、カロニン硫酸、カンゾウエキス、キサンタンガム、キシリトール、キシロース、キチン、キチン・キトサン系高分子、キトサン、キャラガム、グアーガム、グアーヒドロキシプロピルトリモニウムクロリド等のカチオン化多糖類、クィーンスシード、グリコーゲン、グリシン結合ペプチド、グルコース、グルコマンナン、クロトン酸を含むカルボキシル基を有するモノマー、ケイ酸アルミニウムマグネシウム複合体、ケイ酸ナトリウムマグネシウム複合体、ケラチン分解ペプチド、ケラト硫酸複合体、ゲランガム、ゴマリグナン配糖体、コムギデンプン、コメデンプン、コラーゲン、コラーゲン分解ペプチド、コンキオリン分解ペプチド、コンドロイチン硫酸、コンドロイチン硫酸ナトリウム、コンドロイチン硫酸塩、コンフリーエキス、サクシノグルカン、ザンサンガム、ジ−n−ブチルアミン、ジアセトンアクリルアミドを含むアミド基を有するモノマー、ジアルキルジメチルアンモニウム硫酸セルロース、ジアルキルリン酸金属塩複合体、ジエチルアクリル等のアルキル（メタ）アクリルアミド、ジエチレングリコール、ジエチレングリコールジブチルエーテル、ジエチレングリコールモノエチルエーテル、ジエチレングリコールモノメチルエーテル、ジェランガム、ジグリセリン複合体、シクロデキストリン、シスチン複合体、システイン複合体、ジプロピレングリコール、ジベンジリデンソルビトール、ジペンタエリスリトール、ジメチルアクリルアミド、ジメチルアミノアクリレートを含むアミノ基を有するモノマー、ジメチルジオクタデシルアンモニウムモンモリロナイトクレー複合体、ジメチルベンジルドデシルアンモニウムモンモリロナイトクレー複合体、ショ糖ステアリン酸エステル、ショ糖パルミチン酸エステル、ショ糖脂肪酸エステル、シリコーン系エラストマーポリエステル、シリコーン重合体、シリコーン油、シリル化ペプチド、シルクエキス、シルク蛋白分解ペプチド、シロキクラゲ多糖体、シロキクラゲ抽出物、スチレン、スチレン−イソプレン−スチレンブロックコポリマー（SIS）、スチレン−エチレン／ブチレン−スチレンブロックコポリマー（SEBS）、スチレン−エチレン／プロピレン−スチレンブロックコポリマー（SEPS）、スチレン−ブタジエンアクリル酸共重合体アイオノマー、スチレン−ブチレン−スチレンブロックコポリマー（SBS）、スチレン−メタクリル酸共重合体アイオノマー、スチレン・イソプレン・スチレンブロック共重合体、スチレン−イソプレン−ブチレンブロック共重合体、スチレン−イソプレン共重合体、スチレン−ブタジエン共重合体、スチレンコポリマー、スチレン系樹脂、ステアリルアクリレート、ステアリルメタクリレート、スフィンゴ糖脂質、スルホン化エチレン−プロピレン−ジエン共重合体アイオノマー、スルホン化スチレン−２−アクリルアミド−２−メチルプロパンサルフェイトアイオノマー、スルホン化ポリスチレンアイオノマー、スレオニン複合体、ゼラチン、セラミド、セリン複合体、セルロース、セルロース硫酸ナトリウム、ソルビトール、タウリン、タマリンド、タラガム、チューベロース多糖体、チロシン複合体、デオキシリボース、デキストラン、デキストリン、デキストリン２−エチルヘキサン酸パルミチン酸エステル、デキストリンステアリン酸エステル、デキストリンパルミチン酸エステル、デキストリン脂肪酸エステル、デキストリン脂肪酸エステル複合体、デシルアクリレート、デシルメタクリレート、デルマタン硫酸、テレケリックポリブタジエンアクリル酸アイオノマー、デンプン、トウモロコシデンプン、トラガントガム、トリエチレングリコール、トリプトファン複合体、トリメチルグリシン複合体、トリメチロールプロパン、トレイトール、トレオース、トレハロース、トロロアオイ、ナイロン、ナイロン系樹脂、ニトロセルロース、ハイドロキシアパタイト系高分子、ハイドロキシプロピル（メタ）アクリレート、ハマメリス抽出物、バリエナミン複合体、バリダトール複合体、バリダミン複合体、バリン複合体、パルミトイルオリゴペプチド、パルミトイルテトラペプチド、パルミトイルペンタペプチド、バレイショデンプン、パンテノール、ヒアルロン酸、ヒアルロン酸Na、ヒスチジン複合体、ヒドロキシアルキル化シクロデキストリン、ヒドロキシエチルセルロース、ヒドロキシセラミド、ヒドロキシプロピルセルロース、ヒドロキシプロピルセルロース又はその塩、ヒドロキシプロリン、ヒドロキシメチル及びヒドロキシプロピルセルロース、ビニルピドリドン・ビニルアルコール共重合体、ビニルピロリドン、ビニルピロリドン・メタクリル酸ジアルキルアミノアルキル共重合体、ヒポタウリン、ファーセレラン、フェニルアラニン複合体、フコイダン、フコース、ブタジエン複合体、ブチルアクリレート、ブチルメタクリレート、ブチレン−アクリル酸共重合体アイオノマー、フッ素系アイオノマー、フッ素系高分子、ブトキシメチルアクリルアミド、フラクトオリゴ糖脂肪酸エステル、フルクトース、プルラン、プロピレン、プロピレン−α−オレフィン共重合体、プロピレン−アクリル酸共重合体アイオノマー、プロピレン−メタクリル酸共重合体アイオノマー、プロピレングリコール、ヘキシルアクリレート、ヘキシレングリコール、ペクチン、ペクチン酸、ヘクトライト、ベタイン、ヘチマ水抽出物、ヘパリン、ペプチド、ベンジリデン誘導体、ペンタエリスリトール、ペンチレングリコール、ベントナイト複合体、ホスホリルコリン、ポリ−β−ヒドロキシ酪酸（PHB）、ポリ−β−ヒドロキシ酪酸（PHB）等のポリ（β−ヒドロキシアルカノエート）、ポリ−ε−カプロラクトン（PCL）、ポリ−ε−カプロラクトン（PCL）等のポリ（ω−ヒドロキシアルカノエート）、ポリ（α−ヒドロキシ酸）系高分子、ポリ（β−ヒドロキシアルカノエート）系高分子、ポリ（ω−ヒドロキシアルカノエート）、ポリ（ビニルトリメチルアンモニウム塩）アイオノマー、ポリ（ビニルピリジウム塩）アイオノマー、ポリ（ビニルベンジルホスホニウム塩）アイオノマー、ポリ（メタ）アクリル酸エステル、ポリアクリルアミド、ポリアクリルアルキルエステルエマルジョン、ポリアクリル酸、ポリアクリル酸−２−エチルヘキシル、ポリアクリル酸−２−エチルヘキシル・N−ビニル−２−ピロリドン・ジメタクリル酸−１，６−ヘキサングリコール共重合体、ポリアクリル酸−２−エチルヘキシル・酢酸ビニル・アクリル酸共重合体、ポリアクリル酸−２−エチルヘキシル・酢酸ビニル共重合体、ポリアクリル酸・アクリル酸オクチルエステル共重合体、ポリアクリル酸エチルエマルジョン、ポリアクリル酸エチル等のポリアクリル酸エステル共重合体、ポリアクリル酸ヒドロキシエチル、ポリアクリル酸ブチル、ポリアクリル酸メチル、ポリアミド、ポリアミド系高分子、ポリアミノ酸系高分子、ポリアルキレンアルカノエート、ポリイソブチレン、ポリイソプレン、ポリウレタン、ポリウレタンアイオノマー、ポリウレタンエラストマー、ポリウレタン共重合体、ポリエステル、ポリエステル系高分子、ポリエチレン、ポリエチレン−ポリアミドグラフト共重合体、ポリエチレンイミン、ポリエチレングリコール、ポリエチレンサクシネート（PES）、ポリエチレンサクシネート（PES）等のポリアルキレンアルカノエート等、ポリエチレンテレフタレート、ポリエチレンテレフタレート（PET）、ポリエチレンテレフタレートの共重合体、ポリエチレンナフタレート（PEN）、ポリエチレンナフタレートの共重合体等のポリエステル系樹脂、ポリオキシエチレン・ポリオキシプロピレン共重合体、ポリオレフィン、ポリクオタニウム−１０，カチオン化セルロース、ポリクオタニウム−２２等のアクリル酸・ジア
リルジメチルアンモニウムクロリド共重合体、ポリクオタニウム−３９等のアクリル酸・ジアリルジメチルアンモニウムクロリド・アクリルアミド共重合体、ポリクオタニウム−４７等のアクリル酸・アクリル酸メチル・塩化メタクリルアミドプロピルトリメチルアンモニウム共重合体、ポリクオタニウム−５１，２−メタクリロイルオキシエチルホスホリルコリンの重合体、ポリクオタニウム−７，ジアリルジメチルアンモニウムクロリド・アクリルアミド共重合体、ポリグリコール酸（PGA）、ポリグリシン、ポリグリセリン、ポリグルクロン酸、ポリグルコン酸、ポリグルタミン酸、ポリジオキサノン系高分子、ポリテトラフルオロエチレン、ポリテトラフルオロエチレン系高分子、ポリビニルアルコール、ポリビニルアルコール（PVA）、ポリビニルエーテル、ポリビニルピドリドン（PVP）、ポリビニルピロリドン、ポリビニルメチルエーテル、ポリブタジエン、ポリブチレンサクシネート（PBS）、ポリブチレンテレフタレート（PBT）、ポリブチレンテレフタレートの共重合体、ポリプロピレン、ポリプロピレン、ポリプロピレン−ポリアミドグラフト共重合体、ポリプロピレングリコール、ポリペンタマーアイオノマー、ポリメタクリル酸−２−エチルヘキシル、ポリ塩化ビニリデン、ポリ塩化ビニル、ポリ核酸系高分子、ポリ酢酸ビニル樹脂エマルジョン、ポリ酢酸ビニル部分けん化物、ポリ糖鎖、ポリ乳酸（PLA）、ポリ乳酸（PLLA）等のポリ（α−ヒドロキシ酸）、マルチトール、マルトース、マルトシル化シクロデキストリン、マレイン酸、マレイン酸ブチル等のマレイン酸モノアルキルエステル、マレイン酸共重合体、マンナン、マンニトール、マンノース、ミリスチン酸デキストリン、ムコイチン硫酸、ムコ多糖、メタクリル酸アルキルエステル、メタクリル酸エステル共重合体、メタクリル酸グルコシルエチル重合体、メタクリル酸ブチル共重合体等との共重合体、メタクリル酸等のα−β不飽和カルボン酸、メチオニン、メチルセルロース、メチルデンプン等のデンプン系高分子、メチルヒドロキシプロピルセルロース、メチルヒドロキシプロピルデンプン、メチルメタクリレート、メチルメタクリレート−ブタジエン−スチレン樹脂、メリロートエキス、モノベンジリデンソルビトール、ユーカリエキス、ラウリルアクリレート、ラウリルメタクリレート、ラウロイル加水分解シルクナトリウム、ラクチトール、ラクトース、ラフィノース、ラミニトール、リジン、リビトール、リボース、リン酸カルシウム系高分子、ロイシン、ローカストビーンガム、煙霧状シリカ、塩化コリン、塩化ヒドロキシプロピルアンモニウム加水分解コラーゲン、塩化ヒドロキシプロピルトリモニウムデンプン、塩化ビニル、塩化メタクリル酸コリンエステル重合体、加水分解ケラチン、加水分解コラーゲン、加水分解コンキオリン、加水分解シルク、加水分解小麦蛋白、可塑化ポリ塩化ビニル、可塑化酢酸ビニル−塩化ビニル共重合体、核酸、寒天、寒天ガム（agargum）、疑似セラミド、牛顎下腺ムチン、極低密度ポリエチレン、金属石鹸、酵母抽出液、高密度ポリエチレン、合成ラテックス含有高分子エマルジョン、脂肪族ポリエステル系水吸収性樹脂、脂肪族系アイオネン、小麦蛋白分解ペプチド、酢酸セルロース、酢酸ビニル、酢酸ビニル−エチレン共重合体樹脂、水素化ポリペンタマーアイオノマー、水添スチレン−イソプロピレン−ブロック共重合体、水分散性ポリエステル、線状低密度ポリエチレン、多価アルコール、胎盤抽出液、大豆蛋白分解ペプチド、中密度ポリエチレン、超微粒子無水ケイ酸、低密度ポリエチレン、天然ゴム、天然ゴムラテックス、天然保湿因子複合体、天然由来多糖体、糖アルコール、糖セラミド、乳酸ナトリウム、乳酸菌培養液、乳清、粘土鉱物複合体、芳香族系アイオネン、無水ケイ酸複合体、卵殻膜タンパク、蒟蒻ガム、及びこれらのNa,Ca,K,Al,Mg,Znから選択される塩類。
B群：油剤
（アミノエチルアミノプロピルメチコン／ジメチコン）コポリマー、（イソステアリン酸／セバシン酸）ジトリメチロールプロパン、（ヒドロキシステアリン酸／ステアリン酸／ロジン酸）ジペンタエリスリチル、（ヘキシルデカン酸／セバシン酸）ジグリセリルオリゴエステル、１２−ヒドロキシステアリン酸、１２−ヒドロキシステアリン酸コレステリル、２−エチルヘキサン酸セチル、２−エチルヘキサン酸トリグリセリド、N−ラウロイル−L−グルタミン酸ジ（コレステリル／オクチルドデシル）、N−ラウロイル−L−グルタミン酸ジ（コレステリル／ベヘニル／オクチルドデシル）、N−ラウロイル−L−グルタミン酸ジ（フィトステリル／オクチルドデシル）、N−ラウロイル−L−グルタミン酸ジ（フィトステリル／ベヘニル／オクチルドデシル）、N−ラウロイルサルコシンイソプロピル等のアシルサルコシンアルキルエステル、α−オレフィンオリゴマー、アーモンド抽出油、アーモンド油、アイリス抽出油、アシタバ抽出油、アジピン酸イソプロピル、アジピン酸ジイソブチル、アジピン酸ジイソプロピル、アスナロ抽出油、アスパラガス抽出油、アボガド抽出油、アボカド油、アボカド油脂肪酸エチル、アマチャ抽出油、アマニ油、アミノプロピルジメチコン、アミノ酸変性シリコーン、アミノ変性及びポリエーテル変性シリコーン、アモジメチコン、アルキルエーテル変性シリコーン、アルキル変性シリコーン、アルキル変性及びポリエーテル変性シリコーン、アルテア抽出油、アルニカ抽出油、アロエ抽出油、アンズ核抽出油、アンズ抽出油、アンテイソヘンイコサン酸、イソステアリルコレステリルエステル、イソステアリン酸、イソステアリン酸イソプロピル、イソステアリン酸オクチルドデシル、イソステアリン酸コレステリル、イソステアリン酸フィトステリル、イソステアリン酸硬化ヒマシ油、イソノナン酸イソトリデシル、イソノナン酸イソノニル、イソノナン酸オクチル、イソヘキサデカン酸、イチョウ抽出油、インチコウ抽出油、ウイキョウ抽出油、ウーロン茶抽出油、ウコン抽出油、馬油、ウワウルシ抽出油、ウンデシレン酸、エイコサペンタエン酸、エイジツ抽出油、エチナシ葉抽出油、エチレン・プロピレンコポリマー、エルカ酸、エルカ酸オクチルドデシル、エンメイソウ抽出油、オウゴン抽出油、オウバク抽出油、オウレン抽出油、オオムギ抽出油、オクタメチルトリシロキサン、オクタン酸セチル、オクタン酸ヘキシルデシル、オゾケライト、オタネニンジン抽出油、オトギリソウ抽出油、オドリコソウ抽出油、オノニス抽出油、オランダカラシ抽出油、オリーブ油、オリーブ由来スクワラン、オレイン酸、オレイン酸エチル、オレイン酸オクチルドデシル、オレイン酸オレイル、オレイン酸コレステリル、オレンジラッフィー油等の動物性ロウ類；液状ラノリン、オレンジ抽出油、オレンジ油、カカオ脂、カカオ油、カキョク抽出油、カキ葉抽出油、カチオン変性シリコーン、カチオン変性及びポリエーテル変性シリコーン、カッコン抽出油、カモミラ抽出油、カラスムギ抽出油、カルカデ抽出油、カルナウバロウ、カルナウバワックス、カルナバロウ、カルボン酸変性シリコーン、カロット抽出油、カワラヨモギ抽出油、カンゾウ抽出油、キウイ抽出油、キオウ抽出油、キクラゲ抽出油、キナ抽出油、キャンデリラロウ、キャンデリラワックス、キューカンバー抽出油、キリ葉抽出油、グアノシン、グアバ抽出油、クエン酸トリエチル、ククイナッツ油、クジン抽出油、クチナシ抽出油、クマザサ抽出油、クララ抽出油、クリ抽出油、クルミ抽出油、グレープシード油、グレープフルーツ抽出油、クレマティス抽出油、クロレラ抽出油、クワ抽出油、ゲンチアナ抽出油、ゲンノショウコ抽出油、コウボク抽出油、コエンザイムA、コーヒー抽出油、コール酸、コケモモ抽出油、コハク酸ジオクチル、ゴボウ抽出油、ゴマ油、コメヌカ発酵抽出油、コメヌカ油、コメ抽出油、コメ発酵抽出油、コメ胚芽油、コラーゲン、コレステロール、コレステロールオレエート、コンフリー抽出油、サイコ抽出油、サイシン抽出油、サイタイ抽出液、ササ抽出油、サフラワー油、サフラン抽出油、サポゲニン、サポニン類、サボンソウ抽出油、サルビア抽出油、サンザシ抽出油、サンシャ抽出油、サンショウ抽出油、シア脂、ジイソステアリン酸グリセリル、ジイソステアリン酸ジグリセリル、ジイソステアリン酸ダイマージリノレイル、シイタケ抽出油、ジオウ抽出油、ジオクタン酸２−ブチル−２−エチル−１，３−プロパンジオール、ジオクタン酸ネオペンチルグリコール、ジオレイン酸プロピレングリコール、ジカプリン酸ネオペンチルグリコール、シクロメチコン（環状ジメチルシロキサン、シコン抽出油、ジステアリン酸グリコール（ジステアリン酸エチレングリコール）、シソ抽出油、シナノキ抽出油、ジヒドロコレステロール、ジヒドロラノステロール、ジフェニルジメチコン、ジメチコノール、ジメチコノールクロスポリマー、ジメチコン（ジメチルポリシロキサン）、ジメチコンコポリオール、ジメチルオクタン酸ヘキシルデシル、シモツケソウ抽出油、シャクヤク抽出油、ジャトバ抽出油、ショウキュウ抽出油、ショウブ根抽出油、シラカバ抽出油、シリコーンゴム、シリコーン樹脂、スギナ抽出油、スクアラン、スクワラン、スクワレン、ステアリン酸、ステアリン酸コレステリル、ステアリン酸ブチル、ステアロキシプロピルジメチルアミン、ステビア抽出油、ステビア発酵物、スフィンゴミエリン等のスフィンゴリン脂質、セイヨウキズタ抽出油、セイヨウサンザシ抽出油、セイヨウニワトコ抽出油、セイヨウノコギリソウ抽出油、セイヨウハッカ抽出油、セージ抽出油、ゼニアオイ抽出油、セバチン酸ジイソプロピル、セバチン酸ジエチル、セバチン酸ジオクチル、セバチン酸ジブチルオクチル、セレシン、セレシンワックス、センキュウ抽出油、センブリ抽出油、ソウハクヒ抽出油、タートル油等の動物性油脂類；鯨ロウ、ダイオウ抽出油、ダイズ抽出油、タイソウ抽出油、ダイマージリノール酸（フィトステリル／イソステアリル／セチル／ステアリル／ベヘニル）、ダイマージリノール酸（フィトステリル／ベヘニル）、ダイマージリノール酸ジ（イソステアリル／フィトステリル）、ダイマージリノール酸ジイソステアリル、ダイマージリノール酸ジイソプロピル、ダイマージリノール酸ダイマージリノレイル、ダイマージリノール酸硬化ヒマシ油、ダイマージリノレイル水添ロジン縮合物、ダイマー酸、タイム抽出油、タンポポ抽出油、チガヤ抽出油、チョウジ抽出油、チンピ抽出油、ツバキ油、つばき油、ティートリー油、デカ（エルカ酸／イソステアリン酸／リシノレイン酸）ポリグリセリル−８、デカメチルシクロペンタシロキサン、デカメチルシクロペンタシロキサン）、デカメチルテトラシロキサン、テトライソステアリン酸ポリグリセリル、テトラオクタン酸ペンタエリスリチル、トウガラシ抽出油、トウキンセンカ抽出油、トウキ抽出油、トウニン抽出油、トウヒ抽出油、トウヒ油、トウモロコシ油、ドクダミ抽出油、ドコサヘキサエン酸、ドデカメチルシクロヘキサシロキサン、トマト抽出油、トリ（カプリル酸／カプリン酸）グリセリル、トリ（カプリル酸／カプリン酸／ミリスチン酸／ステアリン酸）グリセリル、トリイソステアリン酸グリセリル、トリイソステアリン酸トリメチロールプロパン、トリエチルヘキサン酸ジトリメチロールプロパン、トリエチルヘキサン酸ペンタエリスリチル、トリオクタン酸グリセリル、トリオクタン酸トリメチロールプロパン、トリオレイン酸グリセリル、ナタネ油、ニンジン抽出油、ニンニク抽出油、ネオデカン酸オクチルドデシル、ネオペンタン酸イソステアリル、ネオペンタン酸イソデシル、ネオペンタン酸イソトリデシル、ノナイソステアリン酸ポリグリセリル−１０、ノナン酸コレステリル、ノバラ抽出油、パーシック油、バーチ抽出油、パーフルオロオクタン、パーフルオロデカン、パーフルオロポリエーテル等のフッ素系油剤類、パーム核油、パーム油、ハイビスカス抽出油、バクモンドウ抽出油、ハス抽出油、パセリ抽出油、ハッカ油、ハマメリス抽出油、パラフィンワックス、パリエタリア抽出油、パリミチン酸セチル、パルミチン酸、パルミチン酸イソプロピル、パルミチン酸オクチル、パルミチン酸オクチルドデシル、パルミチン酸ジエタノールアミド（パルタミドDEA）、パルミチン酸モノエタノールアミド（パルタミドMEA）、パルミトオレイン酸、ヒキオコシ抽出油、ピクノジェノール、ビサボロール、ヒドロキシアルキルダイマージリノレイルエーテル、ヒドロキシラノリン、ヒノキ抽出油、ビフィズス菌抽出油、ヒマシ油、ヒマワリ油、ビワ抽出油、フィッシャートロプシュワックス、フィトステロール、フェニルジメチコン、フェニルトリメチコン、フキタンポポ抽出油、フキノトウ抽出油、ブクリョウ抽出油、ブッチャーブルーム抽出油、フッ素変性シリコーン、ブドウ種子抽出油、ブドウ抽出油、プロポリス、ヘーゼルナッツ油、ヘチマ抽出油、ペトロラタム、ベニバナ抽出油、ペパーミント抽出油、ペプチド変性シリコーン、ベヘニン酸、ベヘン酸、ベヘン酸エイコサン二酸グリセリル、ホスファチジルイノシトール、ホスファチジルエタノールアミン、ホスファチジルグリセロール、ホスファチジルコリン、ホスファチジルセリン、ホスファチジン酸、ボダイジュ抽出油、ボタン抽出油、ホップ抽出油、ホホバ油、ポリイソブテン、ポリエチレンワックス、ポリオキシエチレンラノリン、ポリグリセリン変性シリコーン、ポリシロキサン・オキシアルキレン共重合体、ポリブテン、マイカイカ抽出油、マイクロクリスタリンワックス、マカダミアナッツ油、マカデミアナッツ油、マカデミアナッツ油脂肪酸コレステリル、マカデミアナッツ油脂肪酸フィトステリル、マツ抽出油、マロニエ抽出油、ミズバショウ抽出油、ミツロウ、みつろう、ミネラル油、ミリスチン酸、ミリスチン酸イソオクチル、ミリスチン酸イソトリデシル、ミリスチン酸イソプロピル、ミリスチン酸オクタデシル、ミリスチン酸オクチルドデカノール、ミリスチン酸オクチルドデシル、ミリスチン酸ヘキシルデシル、ミリスチン酸ミリスチル、ミンク油、ムクロジ抽出油、メチルシクロポリシロキサン、メチルフェニルポリシロキサン等のメチルフェニルシリコーン油、メチルポリシクロシロキサン等の環状シリコーン油；ポリエーテル変性シリコーン油、メチルポリシロキサン、メドウフォーム油、メリッサ抽出油、モクロウ油、モズク抽出油、モノアルコールカルボン酸エステル、モノイソステアリン酸水添ヒマシ油等のオキシ酸エステル、モモ抽出油、モンタンワックス、ヤグルマギク抽出油、ヤシ油、ヤシ油脂肪酸ジエタノールアミド（コカミドDEA）、ヤシ油脂肪酸メチルエタノールアミド（コカミドメチルMEA）、ヤシ油脂肪酸モノエタノールアミド（コカミドMEA）、ユーカリ抽出油、ユキノシタ抽出油、ユズ抽出油、ユリ抽出油、ヨクイニン抽出油、ヨモギ抽出油、ライスワックス、ラウリン酸、ラウリン酸ジエタノールアミド（ラウラミドDEA）、ラウリン酸ヘキシル、ラウリン酸モノイソプロパノールアミド（ラウラミドMIPA）、ラウリン酸モノエタノールアミド（ラウラミドMEA）、ラノステロール、ラノリン、ラノリン脂肪酸、ラノリン脂肪酸イソプロピル、ラノリン脂肪酸オクチルドデシル、ラベンダー抽出油、リシノレイン酸オクチルドデシル、リゾレシチン等のリン脂質類；水素添加大豆リン脂質、リノール酸、リノレイン酸、リンゴ酸ジイソステアリル、リンゴ抽出油、リン酸変性シリコーン、リン脂質・コレステロール複合体、リン脂質・フィトステロール複合体、ルイボス茶抽出油、レイシ抽出油、レタス抽出油、レモン抽出油、レンギョウ抽出油、レンゲソウ抽出油、ローズヒップ油、ローズマリー抽出油、ローズ抽出油、ローマカミツレ抽出油、ローヤルゼリー抽出油、ロジントリグリセリド（エステルガム）、ワセリン、ワレモコウ抽出油、加水分解エラスチン、加水分解コムギ末、加水分解シルク、海水乾燥物、海藻抽出油、還元ラノリン、吸着精製ラノリン、牛脂、金属石けん類、軽質流動イソパラフィン、鯨ロウ、月見草油、硬化油、硬質ラノリン脂肪酸、硬質ラノリン脂肪酸コレステリル、紅茶抽出油、酵母抽出油、高重合ジメチコン（高重合ジメチルポリシロキサ
ン）、高重合メチルポリシロキサン等のジメチルシリコーン油；オクタメチルシクロテトラシロキサン、黒米抽出油、脂肪酸変性シリコーン、脂溶性黒砂糖抽出物、脂溶性黒酢抽出物、重質流動イソパラフィン、小麦胚芽油、酢酸（セチル・ラノリル）エステル等のラノリン類；レシチン、酢酸コレステリル、酢酸ラノリン、酢酸ラノリンアルコール、酢酸液状ラノリン、水素添加ダイマー酸、水素添加ヒマシ油、水素添加ホホバ油、水素添加ヤシ油、水素添加ロジンペンタエリスリチル、水素添加卵黄リン脂質、水添ポリイソブテン、水添ロジントリグリセリド（水素添加エステルガム）、西河柳抽出油、大豆油、地衣類抽出油、茶抽出油、茶油、丁字油、長鎖α−ヒドロキシ脂肪酸コレステリル、長鎖分岐脂肪酸、長鎖分岐脂肪酸コレステリル、甜茶抽出油、糖変性シリコーン、軟質ラノリン脂肪酸コレステリル、乳酸セチル、乳脂、納豆抽出油、馬脂、白キクラゲ抽出油、部分水素添加大豆リン脂質、部分水素添加卵黄リン脂質、米胚芽油、蜂蜜、蜜ロウ、綿実油、木ロウ、木ろう、油溶性カンゾウ抽出油、落花生油、卵黄油、卵殻膜抽出油、流動パラフィン、流動パラフィン（ミネラル油）、硫酸変性シリコーン、緑茶抽出油、
C群：界面活性剤
２−アルキル−N−カルボキシメチル−N−ヒドロキシエチルイミダゾリニウムベタイン、N−アシルアミノ酸エステル、N−アシルアミノ酸塩、N−ジメチルアミノ酸ベタイン、PPG−９ジグリセリル、α’−オレイン酸ピログルタミン酸グリセリン、α−オレフィンスルホン酸ナトリウム、α−スルホ脂肪酸メチルエステル塩、アクリル酸・メタアクリル酸アルキル共重合体、アシルイセチオン酸塩、アシルグルタミン酸ナトリウム、アシル乳酸塩、アミノプロピルジメチコン及びアモジメチコン、アミノ変性及びポリエーテル変性シリコーン、アルカンスルホン酸塩、アルキルアミン塩、アルキルアリールエーテルリン酸塩、アルキルイソキノリニウム塩、アルキルエーテルアミンモニウム塩、アルキルエトキシジメチルアミンオキシド、アルキルグリシジルエーテルスルホン酸塩、アルキルジメチルアミノエタノールリン酸エステル、アルキルジメチルアミノエタノール硫酸エステル、アルキルジメチルタウリン、アルキルスルホ酢酸塩、アルキルトリアルキレングリコールアンモニウム塩、アルキルナフタレンスルホン酸塩、アルキルベンゼンスルホン酸塩、アルキルベンゼンポリオキシエチレン硫酸塩、アルキルポリグリコシド、アルギン酸ナトリウム、イソステアリルグリセリルエーテル、イソステアリン酸グリセリル、イソステアリン酸ポリグリセリル−２、イソステアレス（ポリオキシエチレンイソステアリルエーテル）、イミダゾリニウム塩、ウンデシレン酸トレハロース、エチル硫酸ラノリン脂肪酸アミノプロピルエチルジメチルアンモニウム、エチル硫酸長鎖分岐脂肪酸（１２〜３１）アミノプロピルエチルジメチルアンモニウム、オクチルドデセス（ポリオキシエチレンオクチルドデシルエーテル）、オレイン酸グリセリル、オレイン酸ポリグリセリル−２、カゼインナトリウム、カチオン変性シリコーン、カチオン変性及びポリエーテル変性シリコーン、カプリリルグルコシド、カルボン酸変性シリコーン、キミルアルコール、コカミドプロピルベタイン、コカミンオキシド、ココアンホ酢酸ナトリウム、ココイルアラニントリエタノールアミン、ココイルグルタミン酸トリエタノールアミン、ココイルグルタミン酸ナトリウム、ココイルメチルタウリンカリウム、ココイルメチルタウリンナトリウム、サーファクチン、サポニン、ジアルキルモリホニウム塩、ジイソステアリン酸ポリグリセリル−２（ジイソステアリン酸ジグリセリル）、ジオレイン酸ポリグリセリル−６、ジココジモニウムクロリド、ジステアリルジモニウムクロリド、ジステアリン酸ポリグリセリル−６、ジメチコンコポリオール、ショ糖脂肪酸エステル、ジラウレスリン酸ナトリウム、ステアラミドエチルジエチルアミン、ステアラミドプロピルジメチルアミン、ステアラミンオキシド、ステアリルトリモニウムブロミド、ステアリン酸グリセリル、ステアリン酸ナトリウム、ステアリン酸ポリグリセリル−２、ステアルトリモニウムクロリド、ステアレス（ポリオキシエチレンステアリルエーテル）類、ステアロイルグルタミン酸ナトリウム、ステアロキシプロピルジメチルアミン、スフィンゴミエリン、スルホコハク酸ジオクチルナトリウム、スルホコハク酸ラウリル２ナトリウム、スルホコハク酸ラウレス２ナトリウム、セスキオレイン酸グリセリン、セチル硫酸ナトリウム、セテス（ポリオキシエチレンセチルエーテル）類、セトリモニウムクロリド、セラキルアルコール、ソホロリピッド、ソルビタンセスキオレエート、ソルビタントリオレエート、ソルビタンモノイソステアレート、ソルビタンモノオレエート、ソルビタンモノステアレート、ソルビタンモノパルミテート、ソルビタンモノラウレート、ソルビタン脂肪酸エステル、ソルビトール部分脂肪酸エステル、デカイソステアリン酸ポリグリセリル−１０、デカオレイン酸ポリグリセリル−１０、デカステアリン酸ポリグリセリル−１０、テトラ−２−エチルヘキシル酸ジグリセロールソルビタン、テトライソステアリン酸ポリグリセリル−２、テトラデシルベンゼンスルホン酸トリエタノールアミン、テトラデシルベンゼンスルホン酸ナトリウム、テトラポリオキシエチレン・テトラポリオキシプロピレン−エチレンジアミン縮合物類、デンプン誘導体、トラガントガム、トリイソステアリン酸ポリグリセリル−２、トリオレイン酸ポリグリセリル−２、トリステアリン酸ポリグリセリル−２、トリラウレスリン酸ナトリウム、バチルアルコール、パルミチン酸カリウム、パルミチン酸グリセリル、パルミチン酸ジエタノールアミド（パルタミドDEA）、パルミチン酸トリエタノールアミン、パルミチン酸モノエタノールアミド（パルタミドMEA）、パルミトイルアスパラギン酸ジトリエタノールアミン、ベヘナミンオキシド、ベヘネス類（ポリオキシエチレンベヘニルエーテル）、ベヘントリモニウムクロリド、ベンザルコニウム塩、ベンゼトニウム塩、ペンタ−２−エチルヘキシル酸ジグリセロールソルビタン、ペンタエリスリトール部分脂肪酸エステル、ホスファチジルイノシトール、ホスファチジルエタノールアミン、ホスファチジルグリセロール、ホスファチジルコリン、ホスファチジルセリン、ホスファチジン酸、ポリアミン脂肪酸誘導体、ポリオール脂肪酸エステル、ポリオキシエチレン・プロピレングリコール脂肪酸エステル、ポリオキシエチレン・ポリオキシプロピレン２−デシルテトラデシルエーテル、ポリオキシエチレン・ポリオキシプロピレンアルキルエーテル、ポリオキシエチレン・ポリオキシプロピレングリコール、ポリオキシエチレン・ポリオキシプロピレングリセリンエーテル、ポリオキシエチレン・ポリオキシプロピレンセチルエーテル、ポリオキシエチレン・ポリオキシプロピレンモノブチルエーテル、ポリオキシエチレン・ポリオキシプロピレン水添ラノリン、ポリオキシエチレンアルキルアミン、ポリオキシエチレンアルキルアミン及びその塩または四級塩、ポリオキシエチレンアルキルエーテル、ポリオキシエチレンアルキルエーテルリン酸、ポリオキシエチレンアルキルエーテル脂肪酸エステル、ポリオキシエチレンアルキルエーテル硫酸塩、ポリオキシエチレンアルキルフェニルエーテル、ポリオキシエチレンアルキルフェニルエーテルリン酸、ポリオキシエチレンアルキルフェノールエーテル、ポリオキシエチレンアルキルメルカプタン、ポリオキシエチレングリセリントリイソステアレート、ポリオキシエチレングリセリンモノイソステアレート、ポリオキシエチレングリセリンモノステアレート、ポリオキシエチレングリセリン脂肪酸エステル、ポリオキシエチレンコレスタノール、ポリオキシエチレンコレステロール、ポリオキシエチレンジオレエート、ポリオキシエチレンジステアレート、ポリオキシエチレンソルビタンテトラオレエート、ポリオキシエチレンソルビタンモノオレエート、ポリオキシエチレンソルビタンモノオレート、ポリオキシエチレンソルビタンモノステアレート、ポリオキシエチレンソルビタン脂肪酸エステル、ポリオキシエチレンソルビトールペンタオレエート、ポリオキシエチレンソルビトールミツロウ、ポリオキシエチレンソルビトールモノオレエート、ポリオキシエチレンソルビトールモノステアレート、ポリオキシエチレンソルビトールモノラウレート、ポリオキシエチレンソルビトール脂肪酸エステル、ポリオキシエチレンヒマシ油、ポリオキシエチレンフィトステロール、ポリオキシエチレンメチルグルコシド脂肪酸エステル、ポリオキシエチレンモノオレエート、ポリオキシエチレンモノオレエート、ポリオキシエチレンラウリルリン酸ナトリウム、ポリオキシエチレンラノリン、ポリオキシエチレン化ステロール、ポリオキシエチレン化ラノリン、ポリオキシエチレン還元ラノリン、ポリオキシエチレン硬化ヒマシ油、ポリオキシエチレン硬化ヒマシ油、ポリオキシエチレン硬化ヒマシ油トリイソステアレート、ポリオキシエチレン硬化ヒマシ油マレイン酸、ポリオキシエチレン硬化ヒマシ油モノイソステアレート、ポリオキシエチレン硬化ヒマシ油モノピログルタミン酸モノイソステアリン酸ジエステル、ポリオキシエチレン脂肪アミン硫酸塩、ポリオキシエチレン脂肪酸アミド、ポリオキシエチレン脂肪酸エステル、ポリグリセリン変性シリコーン、ポリシロキサン・オキシアルキレン共重合体、ポリチレングリコールジイソステアレート、ポリビニルアルコール、マルチトールエーテル、マルチトール部分脂肪酸エステル、ミリスチン酸カリウム、ミリスチン酸グリセリル、ミリストイルグルタミン酸ナトリウム、ミリストイルメチルタウリンナトリウム、メチルグルコシド脂肪酸エステル、モノエルカ酸グリセリン、モノオレスリン酸ナトリウム、モノステアリン酸エチレングリコール、モノステアリン酸エチレングリコール、モノステアリン酸グリセリン、モノステアリン酸グリセリンリンゴ酸、モノステアリン酸プロピレングリコール、モノステアリン酸プロピレングリコール、モノラウロイルモノエタノールアミドポリオキシエチレンスルホコハク酸ナトリウム、モノ綿実油脂肪酸グリセリン、ヤシ油脂肪酸グリセリル、ヤシ油脂肪酸ジエタノールアミド（コカミドDEA）、ヤシ油脂肪酸メチルエタノールアミド（コカミドメチルMEA）、ヤシ油脂肪酸モノエタノールアミド（コカミドMEA）、ラウラミドプロピルベタイン、ラウラミンオキシド、ラウリルジメチルアミノ酢酸ベタイン、ラウリルトリモニウムクロリド等のアルキルトリメチルアンモニウムクロリド、ラウリルベタイン（ラウリルジメチルアミノ酢酸ベタイン）、ラウリルポリプロピレングリコールスルホコハク酸ナトリウム、ラウリルリン酸カリウム、ラウリル硫酸アンモニウム、ラウリル硫酸エステル塩、ラウリル硫酸トリエタノールアミン、ラウリル硫酸ナトリウム、ラウリン酸カリウム、ラウリン酸ジエタノールアミド（ラウラミドDEA）、ラウリン酸モノイソプロパノールアミド（ラウラミドMIPA）、ラウリン酸モノエタノールアミド（ラウラミドMEA）、ラウレス（ポリオキシエチレンラウリルエーテル）類、ラウレスリン酸ナトリウム、ラウレス酢酸ナトリウム、ラウレス硫酸トリエタノールアミン、ラウレス硫酸ナトリウム、ラウロアンホ酢酸ナトリウム、ラウロイルグルタミン酸ナトリウム、ラウロイルグルタミン酸メチルアラニンナトリウム、ラウロイルサルコシントリエタノールアミン、ラウロイルサルコシンナトリウム、ラウロイルメチルアラニンナトリウム、ラウロイルメチルタウリンナトリウム、ラウロイルモノエタノールアミドコハク酸ナトリウム、ラノリンアルコール、リゾレシチン、リン酸変性シリコーン、レシチン等の両性界面活性剤、塩化ジステアリルジメチルアンモニウム、塩化ステアリルジメチルベンジルアンモニウム、塩化ステアリルトリメチルアンモニウム、塩化セチルピリジニウム等のピリジニウム塩、塩化ベンザルコニウム、塩化ベンゼトニウム、塩酸アルキルジアミノエチルグリシン、還元ラノリン、硬化ヤシ油脂肪酸グリセリン硫酸ナトリウム、脂肪酸アミドエーテルリン酸塩、脂肪酸アミドグアニジウム塩、脂肪酸アルカノールアミドエーテルカルボン酸塩、脂肪酸アルカノールアミド硫酸塩、脂肪酸アルキロールアミド、親油型モノオレイン酸グリセリン、水酸化レシチン等のリン脂質類、水素添加大豆リン脂質、水素添加卵黄リン脂質、多価アルコールアルキルエーテル、糖変性シリコーン、部分水素添加大豆リン脂質、部分水素添加卵黄リン脂質、硫酸変性シリコーン
D群：抗酸化物
BHA、BHT、βカロチン、γ−アミノ−β−ヒドロキシ酪酸、アスタキサンチン、アセトキシヒドロキシ安息香酸、エラグ酸、エリソルビン酸及びその誘導体、カミツレ抽出物、グアヤク脂、コウジ酸、ジアセトキシ安息香酸、ジイソプロピルアミンジクロロアセテート、システアミン、システイン、システイン塩酸塩、ジブチルヒドロキシトルエン、ソウハクヒ抽出液、チオグリコール酸、チオグリコール酸、チオグリセロール、チオタウリン、チオ尿素、チオ硫酸ナトリウム、チオ硫酸塩、トコトリエノール、トコフェリルアセテート、トコフェリルジメチルグリシン、トコフェリルニコチネート、トコフェリルリノレート、トコフェリルリン酸Na、トコフェロール、トコフェロール（ビタミンE）、ノルジヒドログアヤレチン酸、ハイドロキノン、ハイドロキノングルコサイド、ハイドロキノンベンジルエーテル、パルミチン酸レチノール、ヒポタウリン、ブチルヒドロキシアニソール、ブチルヒドロキシアニソール、ブチルヒドロキシトルエン、ブチルレゾルシノール、メタ亜硫酸水素塩、メチレンビス（４−メチル−６−t−ブチル）フェノール、ユキノシタ抽出液、レゾルシノール、レチノイン酸、亜硫酸ナトリウム、亜硫酸塩、亜硫酸水素ナトリウム等の亜硫酸水素塩、過酸化水素水、過炭酸、過硫酸アンモニウム、臭素酸ナトリウム、酢酸トコフェロール、酢酸レチノール、胎盤抽出物、米糠抽出物、没食子酸、没食子酸プロピル、没食子酸プロピル、没食子酸誘導体
E群：紫外線吸収遮蔽剤
１,１-ジカルボキシ(２,２'-ジメチルプロピル)-４,４-ジフェニルブタジエン、１,１'-(１,４-ピペラジンジイル)ビス[１-[２-[４-(ジエチルアミノ)-２-ヒドロキシベンゾイル]フェニル]-メタノン、n-ヘキシル２-(４-ジエチルアミノ-２-ヒドロキシベンゾイル)ベンゾエート、p-アミノ安息香酸(PABA)化合物、α-アルキルスチレン由来のダイマー、β-ジフェニルアクリレート化合物、アルミナ、アントラニル化合物、イミダゾリン化合物、エチルヘキシルトリアゾン、オクトクリレン、カンファーベンジルコニウムメトスルフェート、４-メチルベンジリデンカンファー、カンファー化合物、ケイ皮酸化合物、サリチル酸エチルヘキシル、サリチル酸、４,４-ジアリールブタジエン、ブチルメトキシジベンゾイルメタン、ジエチルヘキシルブタミドトリアゾン、ジネオペンチル４'-メトキシベンザルマロネート、ジベンゾイルメタン化合物、シラン、シリカ、シリコーン、テレフタリリデンジカンファースルホン酸、トリアジン化合物、トリス-(ジ-フェニル)-トリアジン、２,４,６-トリス(ジネオペンチル４'-アミノベンザルマロネート)-s-トリアジン、２,４,６-トリス(ジイソブチル４'-アミノベンザルマロネート)-s-トリアジン、２,４,６-トリス-(テル-フェニル)-トリアジン, ２,４,６-トリス-(ジ-フェニル)-トリアジン、 ドロメトリゾールトリシロキサン、ビス-エチルヘキシルオキシフェノールメトキシフェニルトリアジン、ビス-ベンゾアゾリル化合物、ビス[５-１(ジメチルプロピル)ベンゾオキサゾール-２-イル-(４-フェニル)イミノ]-６-(２-エチルヘキシル)イミノ-１,５-トリアジン、フェニルジベンゾイミダゾールテトラスルホン酸二ナトリウム、２,４-ビス-(n-ブチル４'-アミノベンザルマロネート)-６[(３-{１,３,３,３-テトラメチル-１-[(トリメチルシリルオキシ)-ジシロキサニル]プロピル}アミノ)-s-トリアジン、２,４-ビス[５-１(ジメチルプロピル)ベンゾオキサゾール-２-イル-(４-フェニル)イミノ]-６-(２-エチルヘキシル)イミノ-１,３,５-トリアジン、フェニルベンゾイミダゾールスルホン酸、ベンザルマロネート化合物、ベンゾイミダゾール化合物、ベンゾオキサゾール化合物、ベンゾトリアゾール化合物、ベンゾフェノン-３、ベンゾフェノン-４、ベンゾフェノン-５、ベンゾフェノン化合物、ホモサレート、ポリシリコーン-１５、メチルベンジリデンカンファー、メチレンビス-ベンゾトリアゾリルテトラメチルブチルフェノール、メチレンビス(ヒドロキシフェニルベンゾトリアゾール)化合物、メトキシケイ皮酸エチルヘキシル、酸化ジルコニウム、酸化セリウム、酸化チタン(非晶質又はルチル型及び/もしくはアナターゼ型の結晶質)、酸化亜鉛、酸化鉄、遮蔽性ポリマー及び遮蔽性シリコーン、水酸化アルミニウム、
F群：菌増殖抑制物質
１,２−ヘキサンジオール、１,２−ペンタンジオール、EDTA、EDTA２Na、EDTA３Na、EDTA４Na、HEDTA３Na、アムホテリシンB、アラニン、イソプロピルフェノール、イミダゾリニウムウレア、ウンデシレン酸、エキサラミド、エチドロン酸等のホスホン酸、エチルパラベン、エチルアルコール、エリスロマイシン、オキシテトラサイクリン、オクタノール、グルコン酸クロルヘキシジン、クレゾール、クロトリマゾール、クロラムフェニコール、クロルヘキシジン、サリチル酸、シクロピロクスオラミン、シッカニン、ジヒドロキシエチルグリシン、シュウ酸ナトリウム、ジンクピリチオン、ソルビン酸、チアントール、チモール、テトラサイクリン、デヒドロ酢酸、デカノール、トリクロサン酸アミド、トリクロロカルバニド、トリコマイシン、トルナフテート、ナイスタチン、ノルナフテート、パラクロロフェノール、バリオチン、ハロカルバン、ハロプロジン、ヒドロキシエチルエチレンジアミン三酢酸塩、ヒドロキシ安息香酸、ヒノキチオール、ピマフシン、ピロールニトリン、プロピルアルコール、フィチン酸、フェニルエチルアルコール、フェニルフェノール、フェニルフェノールナトリウム、フェニルヨードウンデシノエート、フェノール、フェノキシエタノール、ブチルパラベン、ブチルアルコール、プロピルパラベン、ヘキサクロロフェン、ヘキサノール、へプタノール、ペニシリン、ペンタマイシン、ペンタノール、ペンテト酸塩（ジエチレントリアミン五酢酸塩）、ポリアスパラギン酸、ポリグルタミン酸、ポリリン酸ナトリウム、メタリン酸ナトリウム、メチルイソチアゾリノン、メチルクロロイソチアゾリノン、メチルパラベン、安息香酸ナトリウム、塩化ベンザルコニウム、塩化ベンゼトニウム、感光素類、銀イオン、抗菌性ゼオライト、硝酸イソコナゾール、硝酸エコナゾール、硝酸オモコナゾール、硝酸ケトコナゾール、硝酸スルコナゾール、硝酸チオコナゾール、硝酸ミコナゾール、硫酸フラジオマイシン、
G群：pH調整物質
２−アミノ−２−ヒドロキシメチル−１，３ープロパンジオール、２−アミノ−２−メチル−１，３ープロパンジオール、アクリルアミド−アクリル酸共重合体、アルカリ土類金属水酸化物、アルギニン、アルギン酸、アンモニア、アンモニア水、イソプロパノールアミン、クエン酸、クエン酸、クエン酸ナトリウム、グリコール酸、コハク酸、ジイソプロパノールアミン、ジエタノールアミン、ジエチルアミン、ジメチルアミン、スチレン−マレイン酸無水物共重合体、デンプン−アクリル酸グラフト重合体、トリイソプロパノールアミン、トリエタノールアミン、トリエチルアミン、トリメチルアミン、フマル酸、ポリアクリル酸、ポリアスパラギン酸、ポリイタコン酸、ポリエタノールアミン、ポリグルタミン酸、ポリビニルアセテート−クロトン酸共重合体、ポリビニルスルホン酸、モノエタノールアミン、リンゴ酸、リン酸三ナトリウム、リン酸水素二カリウム、リン酸水素二ナトリウム、塩酸、酒石酸、硝酸、酢酸、酢酸ナトリウム、酢酸ビニル−（メタ）アクリル酸共重合体、酢酸ビニル−クロトン酸共重合体、水酸化カリウム、水酸化カルシウム、水酸化ナトリウム、水酸化マグネシウム、炭酸アンモニウム、炭酸グアニジン、乳酸、乳酸ナトリウム、硫酸。 Means for solving the above problems are as follows.
[1]
A high-purity Gly-Oct-ASA, wherein the total content of one kind selected from monoglyceryl ascorbic acid and monooctyl ascorbic acid and ascorbic acid is 3% by mass or less.
[2]
When measuring the peak area of Gly-Oct-ASA and the peak area other than Gly-Oct-ASA by the liquid chromatogram automatic integration method, the peak area other than Gly-Oct-ASA is less than 5% of the total peak area. The high purity Gly-Oct-ASA of claim 1. [3]
The high purity of claim 1, comprising at least one selected from (Chemical Formula 1) 2-O-glyceryl-3-octyl ASA and the general formula (Chemical Formula 2) 2-O-octyl-3-O-glyceryl ascorbic acid. Gly-Oct-ASA

[4]
In a solution containing sodium chloride and disodium hydrogen phosphate, the standard ascorbic acid or the same mole of Gly-Oct-ASA of the present invention, hemoglobin and hydrogen peroxide are added to cause a Fenton reaction, and a spin trap agent When ascorbic acid radical intensity is measured as the peak height with an electron spin resonance spectrometer, the ascorbic acid radical intensity of Gly-Oct-ASA is 50 of the ascorbic acid radical intensity generated by the same mole of ascorbic acid. % High purity Gly-Oct-ASA of claim 1
[5]
Select from the process of hydrolyzing 3-octyl ASA under acidic conditions, solvent extraction, and column chromatography separation and extraction in the presence of 2-G-3-O-ASA and 3-octyl-ASA A method for producing high-purity 2-o-glyceryl-3-octyl ASA according to claim 1, wherein one or more extraction methods are combined
[6]
A process of hydrolyzing 3-o-glyceryl ascorbic acid under acidic conditions in the coexistence of 2-O-3-G-ASA and 3-glyceryl ascorbic acid, a solvent extraction method, and a column chromatography separation and extraction method A method for producing high-purity 2-o-octyl-3-O-glyceryl ascorbic acid according to claim 1, wherein one or more extraction methods selected from the above are combined.
[7]
Ascorbine with improved levels of lactate dehydrogenase, malate dehydrogenase, aspartate aminotransferase, and stress-ptothein, anti-lipid metabolism improving effect, liver function improving effect and antibody stress effect, with suppressed ascorbate radical generation An oral composition comprising the high purity Gly-Oct-ASA of claim 1 as an acid source.
[8]
A composition comprising the high-purity Gly-Oct-ASA of claim 1 as an ascorbic acid source, which is any one selected from an oral composition, an in-vivo composition, and a chemical product.
[9]
The high-purity Gly-Oct-ASA of claim 1 as an ascorbic acid source selected from pharmaceuticals, quasi-drugs, medical cultures, medical devices, medical devices, unapproved pharmaceuticals, cosmetics, and veterinary cosmetics The composition for external use containing the ascorbic acid radical generation | occurrence | production containing this.
[10]
The composition for external use according to claim 8, which is any one selected from the following product forms:
Product types include eye shadow, eyebrow, eyeliner, insectopelper, water grease, washing pack, essence, enamel remover, emollient cream, emollient lotion, elbow lotion, oil shampoo, oil pack, eau de cologne, eau de toilette, eau de parfum, color Lotion, cream, cream shampoo, cleansing oil, cleansing cream, cleansing gel, cleansing foam, cleansing mask, cleansing milk, cleansing lotion, conditioning shampoo, sunscreen, sunscreen cream, suntan cream, sun protector, sun protect, shaving cream, Gel, shampoo, skin moisture , Perfume, straight perm, set lotion, tic, deodorant cream, deodorant stick, deodorant spray, deodorant powder, deodorant lotion, toner, treatment, night cream, nourishing cream, nourishing milk, nourishing lotion, nail enamel, Nail Treatment, Perm After Treatment, Permanent Wave, Perm Pre Treatment, Bath Oil, Pack, Vanishing Cream, Perfume, Parfum, Hand Lotion, Peel Off Pack, Foundation, Pre Makeup Cream, Protect Emulsion, Hair Oil, Hair Color After Treatment, Hair Color Pre-treatment, hair cream, hair gel, hair Leh, Hair Tonic, Hair Pack, Hair Foam, Hair Bleach, Hair Blow, Hair Manicure, Hair Mist, Moose, Hair Liquid, Hair Wax, Base Cream, Body Powder, Body Shampoo, Body Skin Agent, Body Lotion, Pomade, Mascara, Massage Cream, Manicure, Massage Lotion, Milky Lotion, Milk, Mist, Steam, Makeup Cream, Makeup Lotion, Makeup Agent, Moisture Cream, Moisture Gel, Moisture Lotion, Moisture Emulsion, Lip Gloss, Liniment, Liposome Lotion, Liposome serum, rinse, rinse shampoo, lotion, lotion, hair restorer, liquid soap, makeup base, lotion, toilet soap, keratin sum -Ser, keratin softening cream, lipstick, perfume soap, synthetic cosmetic soap, oxidative hair dye, UV protection essence, depilation cream, soap, facial cleansing powder, facial cleanser, detergent, washing powder, depigmenting agent, depilation / hair removal agent , Insect repellent, patch, transparent soap, ointment, milky lotion, white powder, dusting powder, eyebrow, whitening essence, powder pack, moisturizing essence, aromatic powder, fragrance, deodorant cosmetic, blusher, hair coat, Medicinal soap, bath preparation, shower agent, perfume, mask, socks, gloves, earplugs, hat, cap, socks, underwear, tights, condom, tampon, napkin, ring, bracelet, collar, ankle, earring, bandage, Adhesive bandage, gauze, cloth, suture, skin tape, skin film, skin adhesive, skin stapler, oil removing paper, skin paper, skin clip, skin film, skin ribbon Skin for the paint, skin for the non-woven fabric, skin string, yarn for the skin, the skin tube, patch test kit for skin
[11]
From the improvement of skin stratum corneum moisture, the improvement of epidermal moisture transpiration, the improvement of contact dermatitis, the improvement of erythema, the improvement of acne, the suppression of pathogenic skin resident microorganisms, the improvement of pressure ulcers The composition for external use according to claim 8, which has any improving action selected from
[12]
The ascorbic acid source according to claim 1 having excellent color tone and odor stability in an accelerated test in a long-term high temperature state where the temperature is 40 ° C. ± 2 ° C. and the humidity is 75% RH ± 5% RH for 6 months. The composition for external use according to claim 8, wherein generation of ascorbic acid radicals is suppressed, comprising high-purity Gly-Oct-ASA.
[13]
An emulsified composition having lamellar liquid crystal containing the high-purity Gly-Oct-ASA of claim 1
[14]
The emulsification according to claim 13, which has any action selected from a whitening action, a free radical inhibiting action, an anti-wrinkle action, an anti-acne action, a moisturizing action, a barrier function enhancing action, an ultraviolet ray-derived inflammation inhibiting action, and an anti-decubitus action. Composition
[15]
A single or multiple thickeners selected from two groups of thickeners: a thickener polymer group consisting of one or more of the following Group A thickener polymers and a thickened emulsion composition group described below. A thickening composition comprising: a Gly-Oct-ASA of claim 1 as an ascorbic acid source; an antioxidant selected from group D; an ultraviolet-absorbing screening agent selected from group E; The external use according to claim 8, wherein the viscosity of the thickening substance is stabilized by including at least one viscosity stabilizing substance selected from the group consisting of a fungus growth inhibitory substance selected from the group and a pH adjusting substance selected from the G group. Composition
(Thickening emulsion composition group)
Thickened emulsion composition consisting of one or more of the following Group B oils, one or more Group C surfactants, and water:
Group A: Thickening polymer
(Alkyl acrylate / diacetone acrylamide) copolymer, (alkyl acrylate / diacetone acrylamide) copolymer AMP, (acrylates / stearyl acrylate / ethylamine methacrylate oxide) copolymer, (dimethicone / vinyl dimethicone) crosspolymer, (meth) acrylic The copolymer of the acid alkyl ester includes (methacryloyloxyethylcarboxybetaine / alkyl methacrylate) copolymer, 1,2-butanediol, 1,2-propanediol, 1,2-hexanediol, 1,2-pentanediol, 1,2,3-hexanetriol, 1,2,3-pentanetriol, 1,2-hydroxystearic acid, 1,3-butanediol, 1,3-butylene glycol, 1,3-propanediol, 1,3 − Hexanediol, 1,3-pentanediol, 1,3,4-hexanetriol, 1,3,4-pentanetriol, 1,3,5-hexanetriol, 1,3,5-pentanetriol, 1,3- Butylene glycol, 1,3-propanediol, 1,4-butanediol, 1,4-hexanediol, 1,4-pentanediol, 1,4,6-hexanetriol, 1,5-hexanediol, 1,5 -Pentanediol, 1,6-hexanediol, 2-amino-2-methyl-1,3-propanediol, 2-ethyl-1,3-hexanediol, 2-ethylhexyl acrylate, 2,3,4-pentanetriol , 2-ethylhexyl acrylate, 2-ethylhexyl methacrylate, 2-hydroxyethyl (meth) acrylate 2-methyl-1,3-propanediol, 3-methyl-1,3-butanediol, EVA / PVC / graft copolymer, n-octyl acrylate, N-lauroyl-L-glutamic acid, PGA-PLA system Polymer, α-methylstyrene, β-alanine, β-glucan, ionomer resin, various silicone copolymers such as acrylic-silicone graft copolymer, acrylamide, acrylic elastomer, acrylic acid, 2-ethylhexyl acrylate -Methacrylic acid-2-ethylhexyl-Dodecyl methacrylate copolymer, Acrylic acid-Cationized methacrylic acid amide copolymer, Acrylic acid-Cationized methacrylic acid ester copolymer, Acrylic acid-Alkyl methacrylate copolymer Polymer, acrylic acid / methacrylic acid ester copolymer, alkyl acrylate Ter, methyl acrylate / acrylic acid-2-ethylhexyl copolymer resin emulsion, acrylic resin alkanolamine, acrylic resin emulsion, acrylonitrile, acrylonitrile-butadiene rubber, acylated peptide, acylated peptide and other protein peptides, asparagine, aspartic acid, Atelocollagen, amine ionomer, alanine, gum arabic, arabitol, arabinose, arabinogalactan, arginine, alginic acid, sodium alginate, propylene glycol ester of alginic acid, albumin, aloe extract, Isaiyobara extract, isooctyl acrylate, isooctyl methacrylate, isodecyl acrylate , Isodecyl methacrylate, isononyl acrylate, isobutyl acrylate, Sobutyl methacrylate, isopentanediol, isoleucine, inositol, urethane elastomer, aerostin, ethyl glucoside, ethyl cellulose, ethyl methacrylate, ethylene, ethylene-α-olefin copolymer, ethylene-ethyl acrylate copolymer, ethylene-vinyl sulfonic acid Copolymer ionomer, ethylene-methacrylic acid copolymer ionomer, ethylene-vinyl acetate copolymer, ethylene-acrylic acid copolymer ionomer, ethylene glycol, ethylene glycol / propylene glycol copolymer, ethylene glycol monoethyl ether, ethylene Alkylethylmethanol (meth) acrylamide such as glycol monobutyl ether and ethoxymethylacrylamide, elastin, elastin degradation Peptide, erythritol, octyl acrylate, octenyl succinate corn starch aluminum, curdlan, casein, casein-degrading peptide, cationic polymer, cationized oligosaccharide, cationized dextran, cassava extract, gums, chamomile extract, carrageenan, carrageenan gum, galactan, gal Lactitol, galactose, galactomannan, karaya gum, carboxyvinyl polymer, carboxymethylcellulose and its sodium salt, carboxymethyl starch, caroline sulfate, licorice extract, xanthan gum, xylitol, xylose, chitin, chitin / chitosan polymer, chitosan, carragum , Cationized polysaccharides such as guar gum, guar hydroxypropyltrimonium chloride, queen Susseed, glycogen, glycine-binding peptide, glucose, glucomannan, monomer having carboxyl group including crotonic acid, magnesium aluminum silicate complex, sodium magnesium silicate complex, keratin-degrading peptide, keratosulfuric acid complex, gellan gum, sesame lignan Sugar, wheat starch, rice starch, collagen, collagen-degrading peptide, conchiolin degrading peptide, chondroitin sulfate, chondroitin sulfate sodium, chondroitin sulfate, comfrey extract, succinoglucan, xanthan gum, di-n-butylamine, diacetone acrylamide Monomers having an amide group, dialkyldimethylammonium cellulose sulfate, dialkyl phosphate metal salt complex, alkyl such as diethyl acrylic ( ) Acrylamide, diethylene glycol, diethylene glycol dibutyl ether, diethylene glycol monoethyl ether, diethylene glycol monomethyl ether, gellan gum, diglycerin complex, cyclodextrin, cystine complex, cysteine complex, dipropylene glycol, dibenzylidene sorbitol, dipentaerythritol, dimethyl Acrylamide, monomer having amino group including dimethylamino acrylate, dimethyldioctadecyl ammonium montmorillonite clay complex, dimethylbenzyl dodecyl ammonium montmorillonite clay complex, sucrose stearate ester, sucrose palmitate ester, sucrose fatty acid ester, silicone series Elastomer polyester, silicone polymerization Body, silicone oil, silylated peptide, silk extract, silk proteolytic peptide, white jellyfish polysaccharide, white jellyfish extract, styrene, styrene-isoprene-styrene block copolymer (SIS), styrene-ethylene / butylene-styrene block copolymer (SEBS) , Styrene-ethylene / propylene-styrene block copolymer (SEPS), styrene-butadiene acrylic acid copolymer ionomer, styrene-butylene-styrene block copolymer (SBS), styrene-methacrylic acid copolymer ionomer, styrene / isoprene / styrene block Copolymer, styrene-isoprene-butylene block copolymer, styrene-isoprene copolymer, styrene-butadiene copolymer, styrene copolymer, styrenic resin, stearyl copolymer Relate, stearyl methacrylate, glycosphingolipid, sulfonated ethylene-propylene-diene copolymer ionomer, sulfonated styrene-2-acrylamido-2-methylpropane sulfate ionomer, sulfonated polystyrene ionomer, threonine complex, gelatin, ceramide, Serine complex, cellulose, sodium cellulose sulfate, sorbitol, taurine, tamarind, tara gum, tuberose polysaccharide, tyrosine complex, deoxyribose, dextran, dextrin, dextrin 2-ethylhexanoate palmitate, dextrin stearate, dextrin palmitate Acid ester, dextrin fatty acid ester, dextrin fatty acid ester complex, decyl acrylate, decylme Tacrylate, dermatan sulfate, telechelic polybutadiene acrylate ionomer, starch, corn starch, tragacanth gum, triethylene glycol, tryptophan complex, trimethylglycine complex, trimethylolpropane, threitol, threose, trehalose, troolloi, nylon, nylon resin , Nitrocellulose, Hydroxyapatite polymer, Hydroxypropyl (meth) acrylate, Hamelis extract, Varienamine complex, Validatol complex, Validamin complex, Valine complex, Palmitoyl oligopeptide, Palmitoyl tetrapeptide, Palmitoyl pentapeptide, potato Starch, panthenol, hyaluronic acid, hyaluronic acid Na, histidine complex, hydroxyal Cyclodextrin, hydroxyethylcellulose, hydroxyceramide, hydroxypropylcellulose, hydroxypropylcellulose or salts thereof, hydroxyproline, hydroxymethyl and hydroxypropylcellulose, vinylpidridon / vinyl alcohol copolymer, vinylpyrrolidone, vinylpyrrolidone / dialkylaminomethacrylate Alkyl copolymer, hypotaurine, furceleran, phenylalanine complex, fucoidan, fucose, butadiene complex, butyl acrylate, butyl methacrylate, butylene-acrylic acid copolymer ionomer, fluorine ionomer, fluorine polymer, butoxymethylacrylamide, fructo-oligo Sugar fatty acid ester, fructose, pullulan, propylene, propylene-α Olefin copolymer, propylene-acrylic acid copolymer ionomer, propylene-methacrylic acid copolymer ionomer, propylene glycol, hexyl acrylate, hexylene glycol, pectin, pectic acid, hectorite, betaine, loofah water extract, heparin, Peptides, benzylidene derivatives, pentaerythritol, pentylene glycol, bentonite complexes, phosphorylcholine, poly-β-hydroxybutyric acid (PHB), poly-β-hydroxybutyric acid (PHB) and other poly (β-hydroxyalkanoates), poly- Poly (ω-hydroxyalkanoate) such as ε-caprolactone (PCL), poly-ε-caprolactone (PCL), poly (α-hydroxy acid) polymer, poly (β-hydroxyalkanoate) polymer, poly (Ω-hydroxyl Canoate), poly (vinyltrimethylammonium salt) ionomer, poly (vinylpyridium salt) ionomer, poly (vinylbenzylphosphonium salt) ionomer, poly (meth) acrylate ester, polyacrylamide, polyacrylalkylester emulsion, polyacrylic acid Polyacrylic acid-2-ethylhexyl, polyacrylic acid-2-ethylhexyl, N-vinyl-2-pyrrolidone, dimethacrylic acid-1,6-hexane glycol copolymer, polyacrylic acid-2-ethylhexyl, vinyl acetate, Acrylic acid copolymer, polyacrylic acid-2-ethylhexyl / vinyl acetate copolymer, polyacrylic acid / acrylic acid octyl ester copolymer, polyacrylic acid emulsion, polyacrylic acid such as polyethyl acrylate Stealth copolymer, polyethyl acrylate, polybutyl acrylate, polymethyl acrylate, polyamide, polyamide polymer, polyamino acid polymer, polyalkylene alkanoate, polyisobutylene, polyisoprene, polyurethane, polyurethane ionomer, Polyalkylene alkanoates such as polyurethane elastomer, polyurethane copolymer, polyester, polyester polymer, polyethylene, polyethylene-polyamide graft copolymer, polyethyleneimine, polyethylene glycol, polyethylene succinate (PES), polyethylene succinate (PES) Polyethylene terephthalate, polyethylene terephthalate (PET), polyethylene terephthalate copolymer, polyethylene naphthalate (PEN), polyethylene Acrylic acid and dia such as polyester resin such as copolymer of reethylene naphthalate, polyoxyethylene / polyoxypropylene copolymer, polyolefin, polyquaternium-10, cationized cellulose, polyquaternium-22
Ryldimethylammonium chloride copolymer, acrylic acid / diallyldimethylammonium chloride / acrylamide copolymer such as polyquaternium-39, acrylic acid / methyl acrylate / methacrylamidopropyltrimethylammonium chloride copolymer such as polyquaternium-47, polyquaternium- 51,2-methacryloyloxyethyl phosphorylcholine polymer, polyquaternium-7, diallyldimethylammonium chloride / acrylamide copolymer, polyglycolic acid (PGA), polyglycine, polyglycerin, polyglucuronic acid, polygluconic acid, polyglutamic acid, Polydioxanone polymer, polytetrafluoroethylene, polytetrafluoroethylene polymer, polyvinyl alcohol, polyvinyl alcohol (PVA) Polyvinyl ether, polyvinyl pyridone (PVP), polyvinyl pyrrolidone, polyvinyl methyl ether, polybutadiene, polybutylene succinate (PBS), polybutylene terephthalate (PBT), polybutylene terephthalate copolymer, polypropylene, polypropylene, polypropylene-polyamide graft Copolymer, Polypropylene glycol, Polypentamer ionomer, Poly (2-ethylhexyl methacrylate), Polyvinylidene chloride, Polyvinyl chloride, Polynucleic acid polymer, Polyvinyl acetate resin emulsion, Polyvinyl acetate partial saponified product, Poly sugar chain , Poly (α-hydroxy acids) such as polylactic acid (PLA) and polylactic acid (PLLA), maltitol, maltose, maltosylated cyclodextrin, maleic acid, maleic acid such as butyl maleate Acid monoalkyl ester, maleic acid copolymer, mannan, mannitol, mannose, dextrin myristate, mucoitin sulfate, mucopolysaccharide, alkyl methacrylate ester, methacrylate ester copolymer, glucosylethyl methacrylate copolymer, butyl methacrylate copolymer Copolymers with polymers, etc., α-β unsaturated carboxylic acids such as methacrylic acid, starch polymers such as methionine, methylcellulose, methyl starch, methylhydroxypropylcellulose, methylhydroxypropyl starch, methyl methacrylate, methyl methacrylate Butadiene-styrene resin, merirot extract, monobenzylidene sorbitol, eucalyptus extract, lauryl acrylate, lauryl methacrylate, lauroyl hydrolyzed silk sodium, lacquer Tall, lactose, raffinose, laminitol, lysine, ribitol, ribose, calcium phosphate polymer, leucine, locust bean gum, fumed silica, choline chloride, hydroxypropylammonium hydrolyzed collagen, hydroxypropyltrimonium chloride starch, vinyl chloride, Chloromethacrylic acid choline ester polymer, hydrolyzed keratin, hydrolyzed collagen, hydrolyzed conchiolin, hydrolyzed silk, hydrolyzed wheat protein, plasticized polyvinyl chloride, plasticized vinyl acetate-vinyl chloride copolymer, nucleic acid, agar, Agar gum, pseudoceramide, bovine submandibular gland mucin, very low density polyethylene, metal soap, yeast extract, high density polyethylene, polymer emulsion containing synthetic latex, aliphatic polyester water-absorbing resin, fat Ionene, wheat proteolytic peptide, cellulose acetate, vinyl acetate, vinyl acetate-ethylene copolymer resin, hydrogenated polypentamer ionomer, hydrogenated styrene-isopropylene-block copolymer, water-dispersible polyester, linear low Density polyethylene, polyhydric alcohol, placental extract, soybean proteolytic peptide, medium density polyethylene, ultrafine silica, low density polyethylene, natural rubber, natural rubber latex, natural moisturizing factor complex, naturally derived polysaccharide, sugar alcohol , Sugar ceramide, sodium lactate, lactic acid bacteria culture solution, whey, clay mineral complex, aromatic ionene, anhydrous silicic acid complex, eggshell membrane protein, salmon gum, and their Na, Ca, K, Al, Mg, Salts selected from Zn.
Group B: Oil
(Aminoethylaminopropylmethicone / dimethicone) copolymer, (isostearic acid / sebacic acid) ditrimethylolpropane, (hydroxystearic acid / stearic acid / rosinic acid) dipentaerythrityl, (hexyldecanoic acid / sebacic acid) diglyceryl oligoester, 12-hydroxy Stearic acid, cholesteryl 12-hydroxystearate, cetyl 2-ethylhexanoate, triglyceride 2-ethylhexanoate, N-lauroyl-L-glutamate di (cholesteryl / octyldodecyl), N-lauroyl-L-glutamate di (cholesteryl / Behenyl / octyldodecyl), N-lauroyl-L-glutamate di (phytosteryl / octyldodecyl), N-lauroyl-L-glutamate di (phytosteryl / behenyl / oct) Ludodecyl), acyl sarcosine alkyl esters such as N-lauroyl sarcosine isopropyl, α-olefin oligomer, almond extract oil, almond oil, iris extract oil, ashitaba extract oil, isopropyl adipate, diisobutyl adipate, diisopropyl adipate, asnalo extract oil , Asparagus extract oil, avocado extract oil, avocado oil, avocado oil fatty acid ethyl, amatcha extract oil, linseed oil, aminopropyl dimethicone, amino acid modified silicone, amino modified and polyether modified silicone, amodimethicone, alkyl ether modified silicone, alkyl Modified silicone, alkyl-modified and polyether-modified silicone, Altea extract oil, Arnica extract oil, Aloe extract oil, apricot kernel extract oil, apricot extract oil, anteisoheniko Sanic acid, isostearyl cholesteryl ester, isostearic acid, isopropyl isostearate, octyldodecyl isostearate, cholesteryl isostearate, phytosteryl isostearate, isostearic acid hydrogenated castor oil, isotridecyl isononanoate, isononyl isononanoate, octyl isononanoate, isohexadecanoic acid, Ginkgo biloba extract, Inchkou extract oil, Fennel extract oil, Oolong tea extract oil, Turmeric extract oil, Horse oil, Walnut extract oil, Undecylenic acid, Eicosapentaenoic acid, Ages extract oil, Echinacea leaf extract oil, Ethylene / propylene copolymer, erucic acid , Octyldodecyl erucate, Enmeso extract oil, Ogon extract oil, Oat extract oil, Oren extract oil, Barley extract oil, Octamethyltrisiloxy , Cetyl octoate, hexyldecyl octoate, ozokerite, ginseng extract oil, hypericum extract oil, adriatic extract oil, onionis extract oil, Dutch mustard extract oil, olive oil, olive-derived squalane, oleic acid, ethyl oleate, octyl oleate Animal waxes such as dodecyl, oleyl oleate, cholesteryl oleate, orange luffy oil; liquid lanolin, orange extract oil, orange oil, cocoa butter, cocoa oil, oyster extract oil, oyster leaf extract oil, cation-modified silicone, Cation-modified and polyether-modified silicone, Cascon extract oil, Chamomile extract oil, Oat extract oil, Carcade extract oil, Carnauba wax, Carnauba wax, Carnauba wax, Carboxylic acid modified silicone, Carrot extract oil, Kawarayo Ghi extract oil, licorice extract oil, kiwi extract oil, kiou extract oil, jellyfish extract oil, quince extract oil, candelilla wax, candelilla wax, cucumber extract oil, giraffe leaf extract oil, guanosine, guava extract oil, triethyl citrate , Cucumber nut oil, cucumber extract oil, gardenia extract oil, kumazasa extract oil, clara extract oil, chestnut extract oil, walnut extract oil, grape seed oil, grapefruit extract oil, clematis extract oil, chlorella extract oil, mulberry extract oil, gentian extract Oil, Gennosho extract oil, Koboku extract oil, Coenzyme A, coffee extract oil, cholic acid, bilberry extract oil, dioctyl succinate, burdock extract oil, sesame oil, rice extract fermented oil, rice bran oil, rice extract oil, rice fermented extract oil , Rice germ oil, collagen, cholesterol, cholesterol Late, Comfrey extract oil, Psycho extract oil, Saisin extract oil, Saitai extract, Sasa extract oil, Safflower oil, Saffron extract oil, Sapogenin, Saponins, Soap extract oil, Salvia extract oil, Hawthorn extract oil, Sansha extract Oil, salam extract oil, shea butter, glyceryl diisostearate, diglyceryl diisostearate, dimer linoleyl diisostearate, shiitake extract oil, dio extract oil, 2-butyl-2-ethyl-1,3-propanediol dioctanoate , Neopentyl glycol dioctanoate, propylene glycol dioleate, neopentyl glycol dicaprate, cyclomethicone (cyclic dimethylsiloxane, sykon extract oil, glycol distearate (ethylene glycol distearate), perilla extract oil, Shinano Extract oil, dihydrocholesterol, dihydrolanosterol, diphenyldimethicone, dimethiconol, dimethiconol crosspolymer, dimethicone (dimethylpolysiloxane), dimethiconecopolyol, hexyldecyl dimethyloctanoate, citrus extract oil, peony extract oil, jatoba extract oil, ginger cucumber Extract oil, camphor root extract oil, birch extract oil, silicone rubber, silicone resin, sugina extract oil, squalane, squalane, squalene, stearic acid, cholesteryl stearate, butyl stearate, stearoxypropyldimethylamine, stevia extract oil, stevia Fermented products, sphingophospholipids such as sphingomyelin, kizuta extract oil, hawthorn extract oil, elderberry extract oil, sawtooth Saw extract oil, mint extract oil, sage extract oil, mallow extract oil, diisopropyl sebacate, diethyl sebacate, dioctyl sebacate, dibutyl octyl sebacate, ceresin, ceresin wax, sensu extract oil, assembly extract oil, Sakuha extract oil Animal fats and oils such as turtle oil; whale wax, diou extract oil, soybean extract oil, taiso extract oil, dimer dilinoleic acid (phytosteryl / isostearyl / cetyl / stearyl / behenyl), dimer dilinoleic acid (phytosteryl / behenyl) ), Dimer dilinoleate di (isostearyl / phytosteryl), dimer dilinoleate diisostearyl, dimer dilinoleate diisopropyl, dimer dilinoleate dimer dilinoleyl, dimer dilinoleate cured castor , Dimerinolinoleic hydrogenated rosin condensate, dimer acid, thyme extract oil, dandelion extract oil, chigaya extract oil, clove extract oil, chimpi extract oil, camellia oil, camellia oil, tea tree oil, deca (erucic acid / isostearic acid / Ricinoleic acid) polyglyceryl-8, decamethylcyclopentasiloxane, decamethylcyclopentasiloxane), decamethyltetrasiloxane, polyglyceryl tetraisostearate, pentaerythrityl tetraoctanoate, red pepper extract oil, red pepper extract oil, toki extract oil , Tounin extract oil, spruce extract oil, spruce oil, corn oil, dokudami extract oil, docosahexaenoic acid, dodecamethylcyclohexasiloxane, tomato extract oil, tri (caprylic / capric) glyceryl, tri (caprylic / capri) Acid / myristic acid / stearic acid) glyceryl, glyceryl triisostearate, trimethylolpropane triisostearate, ditrimethylolpropane triethylhexanoate, pentaerythrityl triethylhexanoate, glyceryl trioctanoate, trimethylolpropane trioctanoate, trioleic acid Glyceryl, rapeseed oil, carrot extract oil, garlic extract oil, octyldodecyl neodecanoate, isostearyl neopentanoate, isodecyl neopentanoate, isotridecyl neopentanoate, polyglyceryl nonaisostearate, nonoleate cholesteryl, Novara extract oil, persic oil, birch Extraction oil, fluorinated oils such as perfluorooctane, perfluorodecane, perfluoropolyether, palm kernel oil, palm , Hibiscus extract oil, bacmond extract oil, lotus extract oil, parsley extract oil, mint oil, hamamelis extract oil, paraffin wax, parietalia extract oil, cetyl parmitate, palmitate, isopropyl palmitate, octyl palmitate, octyldodecyl palmitate , Palmitic acid diethanolamide (partamide DEA), palmitic acid monoethanolamide (partamide MEA), palmitooleic acid, anemone extract oil, pycnogenol, bisabolol, hydroxyalkyl dimerlinoleyl ether, hydroxylanolin, hinoki extract oil, bifidobacteria Extracted oil, castor oil, sunflower oil, loquat extract oil, Fischer-Tropsch wax, phytosterol, phenyl dimethicone, phenyl trimethicone, fukitan popo extract oil, Kinoto extract oil, Bukuryo extract oil, Butcher bloom extract oil, Fluorine modified silicone, Grape seed extract oil, Grape extract oil, Propolis, Hazelnut oil, Loofah extract oil, Petrolatum, Safflower extract oil, Peppermint extract oil, Peptide modified silicone, Behenine Acid, behenic acid, glyceryl behenate, glyceryl behenate, phosphatidylinositol, phosphatidylethanolamine, phosphatidylglycerol, phosphatidylcholine, phosphatidylserine, phosphatidic acid, bodaiju extract oil, button extract oil, hop extract oil, jojoba oil, polyisobutene, polyethylene wax, Polyoxyethylene lanolin, polyglycerin modified silicone, polysiloxane-oxyalkylene copolymer, polybutene, micaika extract oil, my Crocrystallin wax, macadamia nut oil, macadamia nut oil, macadamia nut oil fatty acid cholesteryl, macadamia nut oil fatty acid phytosteryl, pine extract oil, maronier extract oil, citrus extract oil, beeswax, beeswax, mineral oil, myristic acid, isooctyl trisyl myristate , Methylphenyl silicones such as isopropyl myristate, octadecyl myristate, octyldodecyl myristate, octyldodecyl myristate, hexyldecyl myristate, myristyl myristate, mink oil, mukuroji extract oil, methylcyclopolysiloxane, methylphenylpolysiloxane Oil, cyclic silicone oil such as methylpolycyclosiloxane; polyether-modified silicone oil, methylpolysiloxane Sun, Meadow Foam Oil, Melissa Extract Oil, Owl Oil, Mozuku Extract Oil, Monoalcohol Carboxylate, Oxyacid Esters such as Monoisostearic Acid Hydrogenated Castor Oil, Peach Extract Oil, Montan Wax, Cornflower Extract Oil, Palm Oil, Coconut oil fatty acid diethanolamide (cocamide DEA), coconut oil fatty acid methyl ethanolamide (cocamide methyl MEA), coconut oil fatty acid monoethanolamide (cocamide MEA), eucalyptus extract oil, yukinoshita extract oil, yuzu extract oil, lily extract oil, yokuinin extract Oil, mugwort extract oil, rice wax, lauric acid, lauric acid diethanolamide (lauramide DEA), lauric acid hexyl, lauric acid monoisopropanolamide (lauramide MIPA), lauric acid monoethanolamide (lauramide MEA), lanosterol, Phospholipids such as Norin, Lanolin Fatty Acid, Lanolin Fatty Acid Isopropyl, Lanolin Fatty Acid Octyl Decyl, Lavender Extract Oil, Octyldodecyl Risinoleate, Lysolecithin; Hydrogenated Soy Phospholipid, Linoleic Acid, Linolenic Acid, Diisostearyl Malate, Apple Extract Oil, phosphate-modified silicone, phospholipid / cholesterol complex, phospholipid / phytosterol complex, rooibos tea extract oil, litchi extract oil, lettuce extract oil, lemon extract oil, forsythia extract oil, forsythia extract oil, rosehip oil, Rosemary extract oil, rose extract oil, Roman chamomile extract oil, royal jelly extract oil, rosin triglyceride (ester gum), petrolatum, walnut extract oil, hydrolyzed elastin, hydrolyzed wheat powder, hydrolyzed silk, dried seawater, seaweed Oil extraction, reduced lanolin, adsorption refined lanolin, beef tallow, metal soaps, light liquid isoparaffin, whale wax, evening primrose oil, hardened oil, hard lanolin fatty acid, hard lanolin fatty acid cholesteryl, black tea extract oil, yeast extract oil, highly polymerized dimethicone ( Highly polymerized dimethylpolysiloxa
), Dimethyl silicone oil such as highly polymerized methylpolysiloxane; octamethylcyclotetrasiloxane, black rice extract oil, fatty acid modified silicone, fat-soluble brown sugar extract, fat-soluble black vinegar extract, heavy fluid isoparaffin, wheat germ oil Lanolins such as acetic acid (cetyl lanolyl) ester; lecithin, cholesteryl acetate, lanolin acetate, lanolin acetate alcohol, liquid lanolin acetate, hydrogenated dimer acid, hydrogenated castor oil, hydrogenated jojoba oil, hydrogenated coconut oil, hydrogen Additive rosin pentaerythrityl, hydrogenated egg yolk phospholipid, hydrogenated polyisobutene, hydrogenated rosin triglyceride (hydrogenated ester gum), Nishiheaya extract oil, soybean oil, lichen extract oil, tea extract oil, tea oil, clove oil, Long chain α-hydroxy fatty acid cholesteryl, long chain branched fatty acid, long chain branched fatty acid choles Lil, strawberry tea extract, sugar-modified silicone, soft lanolin fatty acid cholesteryl, cetyl lactate, milk fat, natto extract oil, horse fat, white jellyfish extract oil, partially hydrogenated soybean phospholipid, partially hydrogenated egg yolk phospholipid, rice germ oil, honey , Beeswax, cottonseed oil, tree wax, beeswax, oil-soluble licorice extract oil, peanut oil, egg yolk oil, eggshell membrane extract oil, liquid paraffin, liquid paraffin (mineral oil), sulfate-modified silicone, green tea extract oil,
Group C: Surfactant
2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, N-acyl amino acid ester, N-acyl amino acid salt, N-dimethylamino acid betaine, PPG-9 diglyceryl, α-oleic acid pyroglutamate glycerin Α-olefin sulfonic acid sodium salt, α-sulfo fatty acid methyl ester salt, acrylic acid / methacrylic acid alkyl copolymer, acyl isethionate, sodium acyl glutamate, acyl lactate, aminopropyl dimethicone and amodimethicone, amino-modified and poly Ether-modified silicone, alkanesulfonate, alkylamine salt, alkylaryl ether phosphate, alkylisoquinolinium salt, alkyletheraminemonium salt, alkylethoxydimethylamine oxide, alkyl Lysidyl ether sulfonate, alkyldimethylaminoethanol phosphate, alkyldimethylaminoethanol sulfate, alkyldimethyltaurine, alkylsulfoacetate, alkyltrialkylene glycol ammonium salt, alkylnaphthalenesulfonate, alkylbenzenesulfonate, alkylbenzene Polyoxyethylene sulfate, alkyl polyglycoside, sodium alginate, isostearyl glyceryl ether, glyceryl isostearate, polyglyceryl isostearate, isosteares (polyoxyethylene isostearyl ether), imidazolinium salt, undecylenic acid trehalose, ethyl lanolin sulfate Fatty acid aminopropylethyldimethylammonium, ethyl sulfate long chain branched fat (12-31) aminopropylethyldimethylammonium, octyldodeces (polyoxyethylene octyldodecyl ether), glyceryl oleate, polyglyceryl-2 oleate, sodium caseinate, cation-modified silicone, cation-modified and polyether-modified silicone, caprylyl glucoside, Carboxylic acid-modified silicone, chimyl alcohol, cocamidopropyl betaine, cocamine oxide, sodium cocoamphoacetate, cocoylalanine triethanolamine, cocoylglutamate triethanolamine, cocoylglutamate sodium, cocoylmethyltaurine potassium, cocoylmethyltaurine sodium, surfactin , Saponin, dialkyl morpholinium salt, polyglyceryl-2 diisostearate (di Diglyceryl isostearate), polyglyceryl-6 dioleate, dicocodimonium chloride, distearyldimonium chloride, polyglyceryl distearate-6, dimethicone copolyol, sucrose fatty acid ester, sodium dilaureth phosphate, stearamide ethyl diethylamine, stearamide propyl Dimethylamine, stearamine oxide, stearyltrimonium bromide, glyceryl stearate, sodium stearate, polyglyceryl-2 stearate, steartrinium chloride, steareth (polyoxyethylene stearyl ether) s, sodium stearoyl glutamate, stearoxypropyldimethylamine , Sphingomyelin, dioctyl sodium sulfosuccinate, lauric sulfosuccinate Disodium, laureth disodium sulfosuccinate, glyceryl sesquioleate, sodium cetyl sulfate, ceteth (polyoxyethylene cetyl ether), cetrimonium chloride, cerakil alcohol, sophorolipid, sorbitan sesquioleate, sorbitan trioleate, sorbitan monoiso Stearate, sorbitan monooleate, sorbitan monostearate, sorbitan monopalmitate, sorbitan monolaurate, sorbitan fatty acid ester, sorbitol partial fatty acid ester, polyglyceryl-10 decaisostearate, polyglyceryl-10 decaoleate, polyglyceryl decastearate 10. Diglycerolsorbitan tetra-2-ethylhexylate, polyglyceryl tetraisostearate 2, tetradecylbenzenesulfonic acid triethanolamine, sodium tetradecylbenzenesulfonate, tetrapolyoxyethylene / tetrapolyoxypropylene-ethylenediamine condensates, starch derivatives, tragacanth gum, polyglyceryl-2 triisostearate, polyglyceryl trioleate 2. Polyglyceryl-2 tristearate, sodium trilaureth phosphate, batyl alcohol, potassium palmitate, glyceryl palmitate, palmitate diethanolamide (partamide DEA), palmitate triethanolamine, palmitate monoethanolamide (partamide MEA) , Palmitoyl aspartate ditriethanolamine, behenamine oxide, behenes (polyoxyethylene behenyl ether), Behentrimonium chloride, benzalkonium salt, benzethonium salt, diglycerol sorbitan penta-2-ethylhexylate, pentaerythritol partial fatty acid ester, phosphatidylinositol, phosphatidylethanolamine, phosphatidylglycerol, phosphatidylcholine, phosphatidylserine, phosphatidic acid, polyamine fatty acid derivatives , Polyol fatty acid ester, polyoxyethylene / propylene glycol fatty acid ester, polyoxyethylene / polyoxypropylene 2-decyltetradecyl ether, polyoxyethylene / polyoxypropylene alkyl ether, polyoxyethylene / polyoxypropylene glycol, polyoxyethylene・ Polyoxypropylene glycerin ether, polyoxy Ethylene / polyoxypropylene cetyl ether, polyoxyethylene / polyoxypropylene monobutyl ether, polyoxyethylene / polyoxypropylene hydrogenated lanolin, polyoxyethylene alkylamine, polyoxyethylene alkylamine and its salt or quaternary salt, polyoxy Ethylene alkyl ether, polyoxyethylene alkyl ether phosphoric acid, polyoxyethylene alkyl ether fatty acid ester, polyoxyethylene alkyl ether sulfate, polyoxyethylene alkyl phenyl ether, polyoxyethylene alkyl phenyl ether phosphoric acid, polyoxyethylene alkyl phenol ether, Polyoxyethylene alkyl mercaptan, polyoxyethylene glycerin triisostearate, polyoxyethylene Nglycerin monoisostearate, polyoxyethylene glycerin monostearate, polyoxyethylene glycerin fatty acid ester, polyoxyethylene cholestanol, polyoxyethylene cholesterol, polyoxyethylene dioleate, polyoxyethylene distearate, polyoxyethylene Sorbitan tetraoleate, polyoxyethylene sorbitan monooleate, polyoxyethylene sorbitan monooleate, polyoxyethylene sorbitan monostearate, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene sorbitol pentaoleate, polyoxyethylene sorbitol beeswax, poly Oxyethylene sorbitol monooleate, polyoxyethylene sorbitol monostearate, poly Oxyethylene sorbitol monolaurate, polyoxyethylene sorbitol fatty acid ester, polyoxyethylene castor oil, polyoxyethylene phytosterol, polyoxyethylene methyl glucoside fatty acid ester, polyoxyethylene monooleate, polyoxyethylene monooleate, polyoxyethylene Sodium lauryl phosphate, polyoxyethylene lanolin, polyoxyethylenated sterol, polyoxyethylenated lanolin, polyoxyethylene reduced lanolin, polyoxyethylene hydrogenated castor oil, polyoxyethylene hydrogenated castor oil, polyoxyethylene hydrogenated castor oil triiso Stearate, polyoxyethylene hydrogenated castor oil maleic acid, polyoxyethylene hydrogenated castor oil monoisostearate, polyoxyethylene hard Castor oil monopyroglutamic acid monoisostearic acid diester, polyoxyethylene fatty amine sulfate, polyoxyethylene fatty acid amide, polyoxyethylene fatty acid ester, polyglycerin-modified silicone, polysiloxane-oxyalkylene copolymer, polyethylene glycol diisostearate Rate, polyvinyl alcohol, maltitol ether, maltitol partial fatty acid ester, potassium myristic acid, glyceryl myristate, sodium myristoyl glutamate, sodium myristoyl methyl taurate, methyl glucoside fatty acid ester, glyceryl monoerucate, sodium monoolesate, ethylene glycol monostearate , Ethylene glycol monostearate, glyceryl monostearate, monostea Glyceric malic acid, propylene glycol monostearate, propylene glycol monostearate, monolauroyl monoethanolamide sodium polyoxyethylene sulfosuccinate, mono cottonseed oil fatty acid glycerin, coconut oil fatty acid glyceryl, coconut oil fatty acid diethanolamide (cocamide DEA), Alkyltrimethylammonium chloride such as coconut oil fatty acid methylethanolamide (cocamide methyl MEA), coconut oil fatty acid monoethanolamide (cocamide MEA), lauramidopropyl betaine, lauramine oxide, lauryldimethylaminoacetic acid betaine, lauryltrimonium chloride, lauryl betaine (Betaine lauryldimethylaminoacetate), sodium lauryl polypropylene glycol sulfosuccinate, sodium lauryl phosphate Lithium, ammonium lauryl sulfate, lauryl sulfate ester salt, lauryl sulfate triethanolamine, sodium lauryl sulfate, potassium laurate, lauric acid diethanolamide (lauramide DEA), lauric acid monoisopropanolamide (lauramide MIPA), lauric acid monoethanolamide (lauramide) MEA), laureth (polyoxyethylene lauryl ether), sodium laureth phosphate, sodium laureth acetate, triethanolamine laureth sulfate, sodium laureth sulfate, sodium lauroamphoacetate, sodium lauroyl glutamate, sodium lauroyl glutamate methylalanine, lauroyl sarcosine triethanolamine , Sodium lauroyl sarcosine, sodium lauroyl methylalanine, lau Amphoteric surfactants such as sodium roylmethyl taurate, sodium lauroyl monoethanolamide succinate, lanolin alcohol, lysolecithin, phosphate-modified silicone, lecithin, distearyldimethylammonium chloride, stearyldimethylbenzylammonium chloride, stearyltrimethylammonium chloride, cetyl chloride Pyridinium salts such as pyridinium, benzalkonium chloride, benzethonium chloride, alkyldiaminoethylglycine hydrochloride, reduced lanolin, hydrogenated coconut oil fatty acid sodium glycerin sulfate, fatty acid amide ether phosphate, fatty acid amide guanidinium salt, fatty acid alkanolamide ether carboxyl Acid salt, fatty acid alkanolamide sulfate, fatty acid alkylolamide, lipophilic glyceryl monooleate, hydroxylated resin Phospholipids such as down, hydrogenated soybean phospholipid, hydrogenated egg yolk phospholipids, polyhydric alcohol alkyl ethers, sugar-modified silicone, a partially hydrogenated soybean phospholipid, partially hydrogenated egg yolk phospholipid, sulfate-modified silicone
Group D: Antioxidant
BHA, BHT, β-carotene, γ-amino-β-hydroxybutyric acid, astaxanthin, acetoxyhydroxybenzoic acid, ellagic acid, erythorbic acid and its derivatives, chamomile extract, guaiac oil, kojic acid, diacetoxybenzoic acid, diisopropylamine dichloroacetate , Cysteamine, cysteine, cysteine hydrochloride, dibutylhydroxytoluene, Sakuhak extract, thioglycolic acid, thioglycolic acid, thioglycerol, thiotaurine, thiourea, sodium thiosulfate, thiosulfate, tocotrienol, tocopheryl acetate, tocopheryl dimethyl Glycine, tocopheryl nicotinate, tocopheryl linoleate, tocopheryl phosphate Na, tocopherol, tocopherol (vitamin E), nordihydroguaiaretic acid, hydroquino , Hydroquinone glucoside, hydroquinone benzyl ether, retinol palmitate, hypotaurine, butylhydroxyanisole, butylhydroxyanisole, butylhydroxytoluene, butylresorcinol, metabisulfite, methylenebis (4-methyl-6-t-butyl) phenol, yukinoshita Extract liquid, resorcinol, retinoic acid, sodium sulfite, sulfite, sodium bisulfite and other bisulfites, hydrogen peroxide, percarbonate, ammonium persulfate, sodium bromate, tocopherol acetate, retinol acetate, placenta extract, rice bran extract , Gallic acid, propyl gallate, propyl gallate, gallic acid derivatives
Group E: UV absorption shielding agent
1,1-dicarboxy (2,2′-dimethylpropyl) -4,4-diphenylbutadiene, 1,1 ′-(1,4-piperazinediyl) bis [1- [2- [4- (diethylamino)- 2-hydroxybenzoyl] phenyl] -methanone, n-hexyl 2- (4-diethylamino-2-hydroxybenzoyl) benzoate, p-aminobenzoic acid (PABA) compound, dimer derived from α-alkylstyrene, β-diphenylacrylate compound , Alumina, anthranyl compound, imidazoline compound, ethylhexyl triazone, octocrylene, camphor benzilyl methosulfate, 4-methylbenzylidene camphor, camphor compound, cinnamic acid compound, ethylhexyl salicylate, salicylic acid, 4,4-diarylbutadiene, butylmethoxy Dibenzoylmethane, diethylhexylbutamide triazone , Dineopentyl 4'-methoxybenzalmalonate, dibenzoylmethane compound, silane, silica, silicone, terephthalylidene dicamphorsulfonic acid, triazine compound, tris- (di-phenyl) -triazine, 2,4,6-tris (Dineopentyl 4′-aminobenzalmalonate) -s-triazine, 2,4,6-tris (diisobutyl4′-aminobenzalmalonate) -s-triazine, 2,4,6-tris- (ter- Phenyl) -triazine, 2,4,6-tris- (di-phenyl) -triazine, drometrizole trisiloxane, bis-ethylhexyloxyphenol methoxyphenyl triazine, bis-benzoazolyl compound, bis [5-1 (dimethylpropyl) Benzoxazol-2-yl- (4-phenyl) imino] -6- (2-ethylhexyl) imino-1,5-triazine, phenyldibenzoi Midazol tetrasulfonate disodium, 2,4-bis- (n-butyl 4'-aminobenzalmalonate) -6 [(3- {1,3,3,3-tetramethyl-1-[(trimethylsilyl Oxy) -disiloxanyl] propyl} amino) -s-triazine, 2,4-bis [5-1 (dimethylpropyl) benzoxazol-2-yl- (4-phenyl) imino] -6- (2-ethylhexyl) imino -1,3,5-triazine, phenylbenzimidazole sulfonic acid, benzalmalonate compound, benzimidazole compound, benzoxazole compound, benzotriazole compound, benzophenone-3, benzophenone-4, benzophenone-5, benzophenone compound, homosalate, Polysilicone-15, methylbenzylidene camphor, methylenebis-benzotriazolyltetramethylbutylphenol, methylene (Hydroxyphenylbenzotriazole) compound, ethylhexyl methoxycinnamate, zirconium oxide, cerium oxide, titanium oxide (amorphous or rutile and / or anatase crystalline), zinc oxide, iron oxide, shielding polymer and Shielding silicone, aluminum hydroxide,
Group F: Bacterial growth inhibitor
1,2-hexanediol, 1,2-pentanediol, EDTA, EDTA2Na, EDTA3Na, EDTA4Na, HEDTA3Na, amphotericin B, alanine, isopropylphenol, imidazolinium urea, undecylenic acid, oxalamide, etidronic acid and other phosphonic acids, ethyl Paraben, ethyl alcohol, erythromycin, oxytetracycline, octanol, chlorhexidine gluconate, cresol, clotrimazole, chloramphenicol, chlorhexidine, salicylic acid, cyclopyroxolamine, siccanin, dihydroxyethylglycine, sodium oxalate, zinc pyrithione, sorbic acid , Thianthol, thymol, tetracycline, dehydroacetic acid, decanol, triclosanamide, trichlorocarbanide, tricomycin, tolu Phthalate, nystatin, nornaphthate, parachlorophenol, variotin, halocarban, haloprozin, hydroxyethylethylenediamine triacetate, hydroxybenzoic acid, hinokitiol, pimafucin, pyrrolnitrin, propyl alcohol, phytic acid, phenylethyl alcohol, phenylphenol, Sodium phenylphenol, phenyliodoundecinoate, phenol, phenoxyethanol, butyl paraben, butyl alcohol, propyl paraben, hexachlorophene, hexanol, heptanol, penicillin, pentamycin, pentanol, pentetate (diethylenetriaminepentaacetate), poly Aspartic acid, polyglutamic acid, sodium polyphosphate, sodium metaphosphate, methyl isothi Azolinone, methylchloroisothiazolinone, methylparaben, sodium benzoate, benzalkonium chloride, benzethonium chloride, photosensitizers, silver ions, antibacterial zeolite, isoconazole nitrate, econazole nitrate, omoconazole nitrate, ketoconazole nitrate, sulconazole nitrate, thioconazole nitrate , Miconazole nitrate, fradiomycin sulfate,
Group G: pH adjusting substances
2-amino-2-hydroxymethyl-1,3-propanediol, 2-amino-2-methyl-1,3-propanediol, acrylamide-acrylic acid copolymer, alkaline earth metal hydroxide, arginine, alginic acid , Ammonia, aqueous ammonia, isopropanolamine, citric acid, citric acid, sodium citrate, glycolic acid, succinic acid, diisopropanolamine, diethanolamine, diethylamine, dimethylamine, styrene-maleic anhydride copolymer, starch-acrylic acid Graft polymer, triisopropanolamine, triethanolamine, triethylamine, trimethylamine, fumaric acid, polyacrylic acid, polyaspartic acid, polyitaconic acid, polyethanolamine, polyglutamic acid, polyvinyl acetate -Crotonic acid copolymer, polyvinyl sulfonic acid, monoethanolamine, malic acid, trisodium phosphate, dipotassium hydrogen phosphate, disodium hydrogen phosphate, hydrochloric acid, tartaric acid, nitric acid, acetic acid, sodium acetate, vinyl acetate-( (Meth) acrylic acid copolymer, vinyl acetate-crotonic acid copolymer, potassium hydroxide, calcium hydroxide, sodium hydroxide, magnesium hydroxide, ammonium carbonate, guanidine carbonate, lactic acid, sodium lactate, sulfuric acid.

An ASA derivative that suppresses prooxidantation, a side effect of conventional ASA derivatives, reduces the production of toxic ASA radicals, and exhibits a higher antioxidant effect and related effects compared to conventional ASA derivatives. It is possible to provide an external composition, an oral composition, and a product having excellent durability, which have an excellent antioxidant effect and related effects, and have high safety and stability.

(FIG. 1) The figure which showed the relationship between the sum total of content of monoglyceryl ascorbine and ascorbic acid by HPLC method, the ascorbic acid radical intensity | strength by ESR method, and the erythema inflammation suppression rate by ultraviolet irradiation. (Example 10)
(FIG. 2) The figure which showed the relationship between the peak area other than glyceryl octyl ascorbic acid by HPLC method, the ascorbic acid radical intensity | strength by ESR method, and the erythema inflammation suppression rate by ultraviolet irradiation. (Example 10)

The Gly-Oct-ASA of the present invention according to claim 1 is a highly pure Gly-Oct-AS in which the total content of ASA and one kind selected from monoglyceryl ASA and monooctyl ASA is less than 3% by weight. Only ASA can be used.

Furthermore, when the total content of ASA and one kind selected from monoglyceryl ASA and monooctyl ASA is 1% by mass or less, highly toxic hydroxy radicals and superoxides that are usually detected as ASA radicals increase are detected. Therefore, the ASA glyceryl octyl diester having the total content of monoglyceryl ascorbine and ASA of the present invention of 1% or less is preferable because the antioxidant effect is stronger and can be exhibited perfectly.

 Liquid chromatogram analyzers such as liquid chromatogram (HPLC) and liquid chromatograph mass spectrometer can be used for quantifying high-purity Gly-Oct-ASA in the claims, but Gly-Oct-ASA and monoglyceryl ASA Any analytical instrument having a liquid chromatogram capable of separating and quantifying impurity peaks other than monooctyl ASA, ASA, and Gly-Oct-ASA is not particularly limited.

 As an example, measurement conditions using an HPLC analyzer will be described below, but the present invention is not limited thereto. Dissolve 0.01 g of 2-G-3-O-ASA in 100 ml of water to make a test solution. 10 μl of the test solution was detected using a column packed with polyhydroxymethacrylate resin, detection: 265 nm, eluent: H2KPO4: 0.03 mol / 1, column temperature: 65 ° C., flow rate: 1.2 ml / min. The peak area B other than O-ASA peak area A and 2-G-3-O-ASA was measured by the automatic integration method, and the average value of 10 times was obtained. The standard products of 2-G-3-O-ASA can be those described above.

 As a standard product of Gly-Oct-ASA used for HPLC analysis, it can also be prepared by the following method. Dissolve 30 g of 2-G-3-O-ASA (Amitose GOA manufactured by Seiwa Kasei Co., Ltd.) in 1000 ml of ion-exchanged water, and gradually add 2000 ml of 99.5% ethanol while stirring and let stand for 6 hours. After that, the produced crystals are collected by filtration, dissolved again in 1000 ml of ion-exchanged water, 2000 ml of 99.5% ethanol is gradually added with stirring and left to stand for 6 hours, and the produced crystals are collected by filtration. This crystal was spread on a petri dish and dried under reduced pressure at 35 ° C. and 50 mmHg until the water content measured by the Karl Fischer method was 10% or less, and this was used as a standard product of 2-G-3-O-ASA.

 As a standard product of ASA monoglyceryl, a general sale product (Amitose 2GA manufactured by Seiwa Kasei Co., Ltd.) was prepared in the same manner as the standard product of 2-G-3-O-ASA described above. When these standard products are analyzed by the same liquid chromatogram method as described above, those which do not recognize an impurity peak capable of measuring the peak area are used. As ASA standard, ASA of Japanese Pharmacopoeia can be used, but the purity must be 99.9% by mass or more.

 In claim 3, the high-purity Gly-Oct-ASA of claim 1 includes the general formula (Formula 1) 2-G-3-O-ASA and the general formula (Formula 2) 2-O-3-G- Contains at least one selected from ASA. The ESR spectrometer used in the claims (ESR spectrometer) has a sensitivity of 7 × 109 spins / 0.1 mT (S / N) or higher, a resolution of 2.35 (μT) or higher, and a maximum magnetic field of 1.3. From (T) above, the sweep width (mT) must be selected from a range wider than ± 0.01 to 500 and a measurement frequency range wider than 8.750 to 9.650 (GHz). Examples of suitable models are JES-FA200 spectrometer and JES-FA300 manufactured by JOEL.

The amount of sample used for the measurement is 10-100 μl to be inserted into one capacity, and the electromagnetic wave is attenuated by the amount of water, so the smaller the sample amount, the better. Detailed measurement conditions are described in the Examples, but are not limited thereto. The standard ASA used here can use the Japanese Pharmacopoeia. When the prooxidant effect of the highly pure Gly-Oct-ASA of the present invention was examined with an ESR spectrometer, the ASA radical strength of the Gly-Oct-ASA was 50% or less of the ASA radical strength generated by the same mole of ASA. It was confirmed that there was.

 In the conventional method, Gly-Oct-ASA is known in Japanese Patent Application No. 2009-529057, as a method of reacting 3-octyl ASA and glycidol and a method of reacting 2-glyceryl ASA and octyl halide. There is a high possibility that unreacted 2-glyceryl ASA, 3-octyl ASA and ASA are present in the product. ASA exists because the hydrolysis reaction product of 2-glyceryl ASA and 3-octyl ASA proceeds at the same time although the equilibrium reaction to ASA is small.

 In fact, the results of analysis of the final product by liquid chromatography (HPLC) showed that 2-octyl ASA and ASA were detected as impurities of 2-G-3-O-ASA within a quantifiable range. From 3-G-ASA, 3-glyceryl ASA and ASA are detected as impurities in a quantifiable range.

 Furthermore, monoglyceryl ASA-6-octyl, monoglyceryl ASA-5-octyl, monoglyceryl ASA-5,6-dioctyl, monooctyl ASA-6-glyceryl, monooctyl ASA-5-glyceryl, monooctyl ASA-5 There is a possibility that ASA derivatives such as 2,6-glyceryl, which are free of the 2- and 3-positions of ASA derivatives, may be included in the impurities, but since the preparation cannot be produced, qualitative analysis by high performance liquid chromatography is Impossible. However, although it cannot be identified, it is possible to integrate the area as an impurity peak, so it is possible to measure the peak area of Gly-Oct-ASA and the peak area other than Gly-Oct-ASA by automatic integration. Yes, it is also possible to calculate the ratio of the peak area other than Gly-Oct-ASA and the total peak area.

 The ASA derivatives of these impurities are free at both the 2-position or 2-position and 3-position of ASA, so when reacted under acidic conditions, the 2- and 3-positions are simultaneously blocked by chemical modification. Compared to the target product Gly-Oct-ASA, the impurity ASA derivative is more easily decomposed into water-soluble ASA. In addition, some of the ASA is broken down into lower molecular water-soluble substances such as ketogulonic acid. In other words, the reaction under acidic conditions can selectively decompose impurities into lower molecular weight water-soluble molecules, which enables purification such as solvent extraction in the final step and separation by silica gel column chromatography. In the process, it contributes to further increasing the purity of the target Gly-Oct-ASA.

 Column fillers that can be used in the column chromatography separation and extraction method of claim include strong acid cation exchange resin, weak acid cation exchange resin, strong base anion exchange resin, weak base anion exchange resin, low odor・ There are low-elution anion exchange resin, amphoteric ion exchange resin, chelate resin, synthetic adsorbent, small particle size for chromatographic separation, synthetic adsorbent, gel filtration column, silica gel, etc., but monoglyceryl ASA and monooctyl ASA It is only necessary that impurities other than ASA and Gly-Oct-ASA can be separated from Gly-Oct-ASA of the present invention, and there is no particular limitation under other conditions.

 The adsorption force when using silica gel column chromatography is related to the electrostatic binding force between the charge in the molecule and the -OH group of the silica gel, and the higher the polarity of the charge in the molecule, the higher the polarity. The higher the polarity, the slower the elution, the higher the separation performance between the target Gly-Oct-ASA and impurities, and the higher purity Gly-Oct-ASA is obtained. be able to.

 Examples of the organic solvent that can be used in the extraction method using the solvent according to the claims include ethyl acetate, chloroform, methanol, or a mixed organic solvent of these with water. Monoglyceryl ASA, monooctyl ASA, ASA, Gly-Oct- It is only necessary that impurities other than ASA can be separated from the Gly-Oct-ASA of the present invention by the solvent extraction method, and there are no particular limitations under other conditions.

 Although it does not specifically limit as an acid used for the hydrolysis decomposition reaction of a claim, For example, a sulfuric acid, hydrochloric acid, etc. are mentioned, Preferably, a sulfuric acid is used. These acids can be diluted with water and are not particularly limited, but the acid concentration is in the range of 0.4 to 1.5 N. The reaction temperature may be in the range of 40 ° C to the heating reflux temperature of the reaction solution, and the reaction is preferably performed at a temperature of 70 to 110 ° C. The reaction time is 0.5 to 4 hours. Moreover, organic solvents, such as benzene, toluene, diethyl ether, isopropyl ether, methyl tert-butyl ether, n-propyl alcohol, can also be used for this reaction, for example.

The oral composition, in-vivo composition, and chemical product in the claims include all uses other than the composition for external use. For example, chemical products include cleaning products, miscellaneous goods, clothing, anti-discoloring agents, stabilizers, household antioxidants, odor eliminating agents, household adhesives, industrial antioxidants, Industrial products including industrial reducing agents, water treatment agents, air cleaners, photosensitive materials, industrial discoloration inhibitors, industrial stabilizers, industrial antioxidants, industrial adhesives, deodorizers, etc. This includes building civil engineering supplies such as paints, building antioxidants, and building deterioration inhibitors, and agricultural, forestry and fishery supplies such as food, feed, culture chemicals, fertilizers and animal supplies. The chemical product of the claim of the present invention includes a pharmaceutical product, a quasi-drug, a medical culture drug, a medical device, a medical device, an unapproved pharmaceutical product, a cosmetic product, and any external composition selected from animal cosmetics. Includes products of topical compositions. Specific examples of this include, for example, sports human body tapes used in contact with skin, sports coolants, skin adhesives, necklaces, bracelets, human body adhesive films, human body paints, and human body This includes clothes such as ornaments such as stockings, underwear and masks that come into direct contact with the skin. However, among these external compositions, external compositions corresponding to pharmaceuticals, quasi drugs, medical culture chemicals, medical devices, medical devices, unapproved pharmaceuticals, cosmetics, and animal cosmetics are not included.
The oral composition of the claim includes all products to be administered orally, for example, food, food additives, feed, feed additives, pet food, pharmaceuticals, quasi drugs, medical culture drugs, medical devices, Includes products for oral administration among medical devices, unapproved pharmaceuticals, supplements, drinks, functional foods, beauty foods, veterinary medical devices, veterinary medical devices. For example, a biodegradable capsule material such as an oral capsule gastric camera is also included.
The in-vivo composition of the claim includes all products that are inserted into the body and used in the body by performing surgery or the like by a method other than oral administration or external administration, for example, pharmaceuticals, quasi-drugs, medical culture drugs , Medical devices, medical devices, unapproved pharmaceutical products for use in the body, including implants, stents, artificial blood vessels, biodegradable gauze for the body, sutures for the body, and the like. The chemical product of this claim can take the form of a solid, liquid, powder, glass, gel, foam, steam, granule, spray or the like. The glyceryl octyl ASA of the present invention is added to the oral composition, in-vivo composition and chemical product of the present invention, and 0.001 to 50% by mass of the preparation.

 When these products are exposed to sunlight, oxygen, water, body fluids, etc. for a long period of time, active oxygen is generated in the products, and the molecules in the products are cut, resulting in deterioration over time, peeling, dissolution, cracking, cutting. Cause perforation, disassembly, etc. In these products, ASA and its derivatives have been added as antioxidants to eliminate active acids, but conventional ASA and its derivatives have generated ASA radicals, and their effects could not be fully demonstrated. Tocopherol, its derivatives, and BHT have also been added to the product, but none of them produced prooxidants and did not achieve sufficient effects, but ASA radical generation was suppressed. As a result of containing the high purity Gly-Oct-ASA of the present invention, the generation of ASA radicals is drastically suppressed, and the problems of deterioration, peeling, dissolution, cracking, cutting, perforation and decomposition of these products over time are suppressed. This can be solved and the product life can be extended. These deteriorations over time are likely to occur particularly in products containing active ingredients that are vulnerable to oxidation, such as pharmaceuticals, quasi-drugs, unapproved pharmaceuticals, and cosmetics, and the generation of ASA radicals in the present invention was suppressed. Including the high purity Gly-Oct-ASA of the present invention as an ASA source can dramatically extend the life of these products.

 The external composition of claim is a composition used in contact with the surface of human or animal skin, and is a pharmaceutical product, quasi-drug, medical culture drug, medical device, medical device, unapproved pharmaceutical product, cosmetic product. It is limited to compositions for external use such as animal cosmetics. It is a composition that takes the form of an individual, liquid, powder, gel, foam, vapor, granule, spray, etc., pharmaceuticals, quasi drugs, medical culture drugs, medical devices, medical equipment, unapproved pharmaceuticals, cosmetics, Animal cosmetics. An unapproved drug means a drug that has not been approved for manufacture and sale under Article 14 of the Pharmaceutical Affairs Law, and refers to a composition used under the responsibility of a doctor. In the composition for external use of the present invention, glyceryl octyl ASA of the present invention is added in an amount of 0.001% by mass or more (up to 100% can be added) in the case of a preparation. More preferably, it is added between 0.005% and 10%. If it is 0.001% or less, the ASA radical scavenging activity may be extremely lowered. In order to effectively use the effect of the composition for external use of the present invention, 0.001 to 10 g is applied per square centimeter of skin, but the concentration may increase or decrease depending on the use or individual, and is not limited thereto.

 Regarding the externally applied composition of the claims, the general stability test conditions of pharmaceuticals, quasi-drugs, and cosmetics prescribed by the Pharmaceutical Affairs Law and related laws and regulations, and the temperature are 40 ° C ± 2 ° C, humidity In an accelerated test in a long-term high-temperature state where the product is stored at 75% RH ± 5% RH for 6 months, it is required that there are no problematic changes such as product color tone, odor or viscosity. However, conventional ASA and its derivatives often have not been solved, and have been regarded as a major problem. This problem is solved in an external composition containing the high-purity Gly-Oct-ASA of the present invention as the ASA source of the present invention, in which ASA radical generation is suppressed.

 There are many types of erythema in the claim depending on its shape and cause, such as nodular erythema, infectious erythema, polymorphic exudative erythema, but singular or multiple red spots found on the skin, usually The one that disappears when pressed.

 Skin damage due to ultraviolet rays and radiation damage, infections such as bacteria, viruses and fungi, Behcet's disease, tuberculosis, sarcoidosis, Crohn's disease and other basic diseases, visceral malignancies, drugs, sulfa antibiotics, insect toxins and oral contraception There are things such as drugs. When skin tissue is damaged by active oxygen, erythema develops on the skin surface. Erythema refers to a condition in which the surface of a tissue such as skin becomes red due to expansion of capillaries and the like, and is a form of tissue damage such as inflammation. Vasodilation associated with erythema involves the generation of active oxygen such as NO radicals, superoxide, and ASA radicals due to neutrophil infiltration. In particular, NO radicals are known to have a vasodilatory effect, and vasodilation by other active oxygen is considered to be caused by radical transfer to NO radicals. If erythema is accompanied by arterial dilatation, the skin temperature rises and the amount of active oxygen in the skin increases. Even in the case of ultraviolet rays, radiation damage, and hydrogen peroxide damage, active oxygen is generated in the skin and erythema is generated.

 Erythema disappears when pressed, whereas purpura and pigmentation do not disappear when pressed and are clearly different. Causes of erythema are physical damage such as UV radiation damage, infections (fungi, mycoplasma, viruses, etc.), burns, acne, allergies, massage, electrical treatment, excessive exercise, radiation damage, hair pulling, and surfactants. And chemical reactions with drugs.

 In the occurrence of erythema due to UV irradiation damage, the concentration of superoxide and hydrogen peroxide in the tissue first increases, and as a result, it reacts with iron proteins in the skin and promotes the recycled Fenton reaction. The treatment of this erythema requires elimination of active oxygen by an ASA derivative that does not generate ASA radicals because of the involvement of the recycled Fenton reaction, and is one of the target diseases of the ASA derivative of the present invention. In the conventional ASA and its derivatives, since ASA radicals are generated by ultraviolet irradiation and contact dermatitis is enhanced, the high purity Gly-Oct-ASA of the present invention which does not generate ASA radicals is particularly effective.

 Contact dermatitis is a disease in which eczema such as erythema, papules, and blisters occurs when an external stimulus such as a metal or drug comes into contact with the skin. Contact dermatitis is classified into irritant dermatitis and allergic dermatitis. The former is eczema caused by touching the causative substance, and the latter is dermatitis caused by an immune reaction caused by an allergen substance. Contact dermatitis is cured by eliminating the causative irritant. In contact dermatitis tissue, infiltration of neutrophils is often observed. Therefore, active oxygen such as superoxide, which is associated with neutrophils, is elevated at the site of inflammation. Neutrophils have the ability to produce superoxide and increase the hydrogen peroxide concentration. As a result, in the inflamed tissue in which neutrophil infiltration is observed, it reacts with iron protein and the like to promote the recycle oxidation reaction, and the inflammation becomes more serious. Gly-Oct-ASA, which does not generate ASA radicals, is particularly effective in this field because conventional ASA and its derivatives may worsen the inflammatory site.

 One of the causes of wrinkles is said to be active oxygen. Active oxygen oxidizes the stratum corneum, sebum, and cell membrane of the skin, kills cells, loses the normal function of the skin, and reduces the amount of extracellular matrix. In addition, the fibroblasts in the dermis layer are also damaged, thereby suppressing the production of collagen, elastin, hyaluronic acid and the like that have the role of maintaining the elasticity of the skin.

 Furthermore, active oxygen becomes a stimulus for producing digestive enzymes such as collagenase and elastase, and collagen and elastin are cleaved, and the amount of collagen, elastin and hyaluronic acid decreases. Reactive oxygen damages the cytoskeleton, enlarges skin cells, increases the surface area of the skin, and causes skin damage and wrinkles. The conventional ASA and its derivatives promoted dryness of the skin due to the generation of ASA radicals, and worsened wrinkles and tarmi, so Gly-Oct-ASA, which does not generate ASA radicals, is especially in this field. It is valid.

 Pathogenic skin resident microorganisms refer to skin resident microorganisms involved in skin diseases, including pathogenic skin resident microorganisms such as Staphylococcus aureus, Malassezia, Candida, Trichophyton rubulum, Propionibacterium acnes, etc. However, in the present invention, any microorganism may be used as long as it has past knowledge as a skin resident microorganism and has pathogenicity.

 Pathogenic microorganisms that have the potential to reside in the skin grow abnormally under special conditions and induce various diseases in the skin. Neutrophils infiltrate the skin tissue with abnormally proliferated skin, and generate active oxygen such as superoxide in order to kill bacteria. This active oxygen kills not only pathogenic microorganisms but also skin cells. Superoxide produced by neutrophils increases the hydrogen peroxide concentration. As a result, in the inflamed tissue in which neutrophil infiltration is observed, it reacts with iron protein and the like to promote the recycle oxidation reaction, and the inflammation becomes more serious. Since conventional ASA and its derivatives sometimes exacerbated such inflammatory sites, Gly-Oct-ASA, which does not generate ASA radicals, is particularly effective in this field.

 In addition, prooxidants such as porphyrins and unsaturated fatty acids produced by some skin resident bacteria generate active oxygen such as superoxide, oxidize sebum, damage skin tissue, destroy skin barrier and moisturize. The generation of ASA radicals by applying conventional ASA and its derivatives should be suppressed as much as possible because it reduces the power. The Gly-Oct-ASA having anti-ASA radical activity of the present invention is an effective skin barrier ameliorating agent particularly for dry skin overproduced by porphyrin. Gly-Oct-ASA, which does not generate ASA radicals, has been reported to be particularly effective in this field.

 The thickening polymer and the thickening emulsified composition as claimed in the present invention are those having a viscosity of 0.002 cP (mPa · s) or kinematic viscosity, which is the viscosity of water at 20 ° C. when dissolved in a solvent such as water. Any one of 0.004 cSt (mm2 / s) may be a polymer or a composition having a viscosity or kinematic viscosity twice or more. The specific example was described in the Example. The thickening polymer is used for preparing a high viscosity preparation such as an ointment, and the thickening emulsion composition is effective for preventing dripping, evaporation and separation of the active ingredient from the skin. It can also be used to enhance skin moisture retention and barrier function. For this reason, the thickened emulsion composition group of Claim 12 means the simple substance of the thickened emulsion composition which consists of three or more types of oil agent, 1 or more types of surfactant, and water, or its composite_body | complex.

 These thickening polymers and thickening emulsion compositions are generally composed of large polymers having a molecular weight of 1000 or emulsified particles having a total molecular weight of 1000 or more. Due to the oxygen, the polymer is decomposed over time, and the polymer is reduced in molecular weight to cause a problem of lowering the viscosity, or polymerized to become larger, resulting in a problem of increasing the viscosity. The emulsified particles have a molecular film or the like broken, resulting in a decrease in the number of particles and the problem of a decrease in viscosity.

 These changes in viscosity over time are seriously detrimental to commercial value, so ASA and its derivatives, tocopherol, dibutylhydroxytoluene (BHT), butylhydroxyanisole (BHA), etc. have been used to prevent these viscosity changes. Of antioxidants were added. However, conventional ASA and its derivatives generated ASA radicals, and their effects could not be fully demonstrated. Tocopherol, its derivatives, BHT, BHA, etc. generate prooxidants and cannot obtain sufficient effects. Since the present invention includes the high-purity Gly-Oct-ASA of the present invention as an ASA source in which the generation of ASA radicals is suppressed, the generation of ASA radicals is dramatically suppressed and prooxidants are not generated. Changes in viscosity over time can be suppressed, and the product life can be extended.

 The lamellar liquid crystal of the claim is also called a vesicle structure, and forms a multilayer structure like a sandwich of water-lipid-water-lipid-water ... regularly and alternately as seen in lipids between skin cells. This multilayer structure of thin crystal surfaces is called a lamellar structure (lamella structure = vesicle liquid crystal structure). When emulsified particles with this lamellar liquid crystal structure are observed under a polarizing microscope crossed Nicol, an image of a typical negative spherulite (the slow axis [molecular chain direction] of the refractive index ellipsoid is perpendicular to the radial direction of the spherulite) appears. The resulting image is called a Maltese cross (cross-shaped shadow).

 The presence of the lamellar liquid crystal can be confirmed by confirming the Maltese cross image. Since the lamellar liquid crystal structure of high purity Gly-Oct-ASA of the present invention is similar to the lipid between skin cells, coloring and precipitation are generated compared with the conventional formulation containing Gly-Oct-ASA, and there is a strange odor. Occurrence decreased and the stability of the preparation increased, and the stability period was extended compared to the prescription containing conventional Gly-Oct-ASA. If the stable period of the drug product was extended, the distribution organization became longer, leading to a significant cost reduction.

When making a multi-capsule emulsion preparation of high purity Gly-Oct-ASA of the present invention, the absorption of Gly-Oct-ASA to the skin is increased by 200%, whitening action, free radical inhibitory action, anti-wrinkle action, anti-acne action, Moisturizing action, barrier function enhancing action, ultraviolet ray-derived inflammation suppressing action, anti-decubitus action were enhanced. The preparation using this multi-layer capsule is effective if the effective concentration of Gly-Oct-ASA in the preparation is 0.01% or more. This is thought to be due to an increase in skin absorption rate. Further, no skin irritation was exhibited even when the concentration of Gly-Oct-ASA in the preparation was 10%.

   EXAMPLES Hereinafter, although an Example demonstrates this invention in detail, this invention is not limited to them at all. Unless otherwise specified, the numerical value indicating the content is “mass%”.

(Synthesis of 2-G-3-O-ASA)
Under an argon atmosphere, 5,6-isopropylidene ASA (100.0 g) and sodium hydrogen carbonate (38.8 g) were added to 100 mL of DMSO, stirred at room temperature for 30 minutes, and octyl bromide (133.3 g) was added. The mixture was heated to 50 ° C. and stirred for 24 hours, and then extracted with ethyl acetate. The extract was dried over anhydrous sodium sulfate and concentrated under reduced pressure. To the resulting residue was added 5000 mL of methanol and 1000 mL of a strongly acidic cation exchange resin (Diaion SK1B), and the mixture was stirred at room temperature for 24 hours. It was. The resin was filtered, and 141.5 g of the residue obtained by concentration under reduced pressure was subjected to silica gel column chromatography. Thereafter, elution was performed with a hexane / ethyl acetate = 1/1 mixed solution, followed by concentration under reduced pressure to obtain 3-octyl ASA (74.4 g). To the obtained 3-octyl ascorbyl, 150 mL of DMSO was added and stirred under an argon atmosphere. Sodium hydrogen carbonate (5.2 g) and glycidol (23.1 g) were added, and the mixture was heated to 80 ° C. and stirred for 18 hours. Extracted with ethyl. The extract was dried over anhydrous sodium sulfate and concentrated under reduced pressure. The resulting concentrate, 94.0 g, contains 6% of derivatives other than 93% 2-G-3-O-ASA, 3.0% monooctyl ASA, 0.2% ASA and 2-G-3-O-ASA. % Was included. 94.0 g of the resulting concentrate was divided into two, 47 g of one was used for the production of the following comparative example, and the other 47 g was added with 600 ml of 10% -sulfuric acid aqueous solution and stirred for 2 hours while heating under reflux. After being performed, extraction with ethyl acetate was performed. The extract was dried over anhydrous sodium sulfate and concentrated under reduced pressure. 68.9 g of the obtained residue was subjected to silica gel chromatography. Elution was performed with a mixture of chloroform / methanol / water = 20/3 / 0.4, and concentration was performed under reduced pressure to obtain high purity 2-G-3-O-ASA (10.9 g) of the present invention.

 Comparative Example 47 g of the residue obtained above was subjected to silica gel chromatography. Elution was performed with chloroform / methanol / water = 20/3 / 0.4 mixed solution, followed by concentration under reduced pressure to obtain 2-G-3-O-ASA (8.6 g).

 The obtained product of the present invention was subjected to HPLC, 1H-NMR, 13C-NMR measurement, and IR measurement. From this measurement result, this product was obtained as a high purity 2-G- represented by (Chemical Formula 1). It was confirmed to be 3-O-ASA.

(HPLC analysis of 2-G-3-O-ASA)
2-G-3-O-ASA dehydrated product 0.6g (precisely measured value WAl) and maleic acid 1.00 (exactly measured value WM1) as an internal standard solution are weighed accurately and dissolved in water to make 200ml. To do. Using this as a test solution, measurement is performed by high performance liquid chromatography under the following operating conditions, and the peak area (SA1) of this product and the peak area of maleic acid (SM1) are calculated. Perform the same operation in advance using 0.6 g (precisely measured value WA2) and 1.0 g of maleic acid (accurately measured value WM2) as dehydrated equivalents of 2-G-3-O-ASA standard products. The peak surface reliability SA2 and SM2 were calculated, the content was calculated by the following formula, and the same value was measured 10 times to obtain the average value. Further, ASA and monooctyl ASA contained as impurities in 2-G-3-O-ASA and 2-G-3-O-ASA of Comparative Example were also quantified by the same method as described above. Are summarized in Table 1.

 Quantitative value of 2-G-3-O-ASA% (weight) = (SA1 / WA1) x (WM1 / SM1) x (WA2 / WM2) x (SM2 / SA2) x 100

Operating conditions: Showa Denko Shodex SB-802 HQ, a column packed with polyhydroxymethacrylate resin, detection: 265 nm, eluent: H2KPO4 0.03 mol / 1 (pH 2PO4 adjusted to pH 6), column temperature: 65 ° C. The flow rate was measured under the condition of 1.2 ml / min.
(Standard product creation)
Dissolve 30 g of 2-G-3-O-ASA general sale product (Amitose GOA manufactured by Seiwa Kasei Co., Ltd.) in 1000 ml of ion-exchanged water, then gradually add 2000 ml of 99.5% ethanol and stir for 6 hours while stirring. After that, the produced crystals are collected by filtration, dissolved again in 1000 ml of ion-exchanged water, 2000 ml of 99.5% ethanol is gradually added with stirring and left to stand for 6 hours, and then the produced crystals are collected by filtration. This crystal was spread on a petri dish and dried under reduced pressure at 35 ° C. and 50 mmHg until the water content measured by the Karl Fischer method was 10% or less, and this was used as a standard product of 2-G-3-O-ASA. The standard product of mono-octyl ASA was prepared in the same way as the standard product of 2-G-3-O-ASA above, using 3-octyl ASA in the manufacturing process of 2-G-3-O-ASA. . ASA standard products used ASA of Japanese Pharmacopoeia.

(HPLC analysis conditions using the area method)
2-G-3-O-ASA O.01 g is dissolved in 100 ml of water to make a test solution. 10 μl of the test solution is 2-G-3-O using a column packed with polyhydroxymethacrylate resin, detection: 265 nm, eluent: 0.03 mol / l of H2KPO4, column temperature: 65 ° C., flow rate: 1.2 ml / min. The peak area B other than -ASA peak area A and 2-G-3-O-ASA was measured by the automatic integration method, and the average results are summarized in Table 2. Incidentally, the standard product of 2-G-3-O-ASA described above was used.

The analysis results by IR (infrared absorption spectrum) were as follows.
neat, ATR: 3364cm-1, 2924cm-1, 2857cm-1, 1748cm-1, 1667cm-1, 1331cm-1, 1165cm-1, 1115cm-1, 1036cm-1

The analysis results by NMR (nuclear magnetic resonance spectroscopy) were as follows. 8
1H-NMR (400MHz, CD3OD) δppm
0.90 (3H, m) 1.32 (8H, m), 1.42 (2H, m), 1.75 (2H, m), 3.57 (2H, m), 3.64 (2H, m), 3.86 (2H, m), 3.96 / 3.97 (1H, dd), 4.10 / 4.13 (1H, dd), 4.53 (2H, m), 4.83 (1H, d)
13C-NMR (100MHz, CD3OD) δppm
14.4,23.7,26.7,30.3,30.4,30.6,32.9,63.3,63.99,64.02,70.6,72.0,7 3.7,75.2,75.3,76.67,76.70,122.60,12 2.64,159.9,172.63,172.64

(Synthesis of 2-O-3-G-ASA)
Under an argon atmosphere, ASA (300 g) and sodium hydrogen carbonate (4 2.9 g) were added to water, and the mixture was stirred at room temperature for 30 minutes, and glycidol (126 g) was added. Thereafter, the mixture was heated to 50 ° C. and stirred for 5 hours. Methanol was added and filtered, the filtrate was concentrated under reduced pressure, and 457 g of the resulting residue was subjected to silica gel column chromatography. Elution was performed with chloroform / methanol / water = 65/35/5, followed by concentration under reduced pressure to obtain 3-glyceryl ASA (296 g). 3-Glyceryl ASA (54.1) obtained above under an argon atmosphere.
g) was stirred in DMSO (200 mL), sodium hydrogen carbonate (18.5 g) was further added, and the mixture was stirred at room temperature for 30 minutes. Thereafter, octyl bromide (63.7 g) was added, the mixture was heated to 100 ° C., stirred for 3 hours, and extracted with ethyl acetate. The extract was dried over anhydrous sodium sulfate and concentrated under reduced pressure. In 130 g of the resulting concentrate, 93% of 2-O-3-G-ASA, 3.2% of ASA monoglyceryl, 0.6% of ASA and 6% of plural derivatives other than 2-O-3-G-ASA It was included.

 130 g of this concentrate was divided into two, 115 g was used for the production of the comparative example described below, the other 115 g was added with 300 ml of 10% -sulfuric acid aqueous solution, stirred for 2 hours with heating under reflux, and then acetic acid. Extracted with ethyl. The extract was dried over anhydrous sodium sulfate and concentrated under reduced pressure. 51 g of the obtained residue was subjected to silica gel column chromatography. Elution was performed with a mixed solution of chloroform / methanol / water = 10/3 / 0.4, followed by concentration under reduced pressure to obtain high-purity 2-O-3-G-ASA (18.0 g) of the present invention.

115 g of the residue obtained above was dried over anhydrous sodium sulfate and then concentrated under reduced pressure. 66 g of the obtained residue was subjected to silica gel column chromatography. Elution was performed with a mixed solution of chloroform / methanol / water = 10/3 / 0.4, and concentration was performed under reduced pressure to obtain 2-O-3-G-ASA (24.3 g) as a comparative example. The obtained product of the present invention was subjected to HPLC, 1H-NMR, 13C-NMR measurement and IR measurement, and from this measurement result, this product was highly purified 2-O-3- It was confirmed to be G-ASA.

(Conditions for HPLC analysis)
2-O-3-G-ASA dehydrated 0.6 g (precisely measured value WAl) and internal standard solution 1.00 maleic acid (exactly measured value WM1) are accurately weighed and dissolved in water to 200 ml. To do. Using this as a test solution, measurement is performed by high performance liquid chromatography under the following operating conditions, and the peak area (SA1) of this product and the peak area of maleic acid (SM1) are calculated.

Perform the same operation in advance using 0.6 g (precisely measured value WA2) and 1.0 g of maleic acid (precisely measured value WM2) as dehydrated equivalents of 2-O-3-G-ASA standard products. The peak surface reliability SA2 and SM2 were calculated, the content was calculated according to the following formula, and the same measurement was performed to obtain the average value. Furthermore, ASA and monoglyceryl ASA contained as impurities in 2-O-3-G-ASA and 2-O-3-G-ASA of Comparative Example were also quantified by the same method as described above. Are summarized in Table 3.

Quantitative value of 2-O-octyl-3-O-glyceryl-ascorbic acid% (weight) = (SA1 / WA1) X (WM1 / SM1) X (WA2 / WM2) x (SM2 / SA2) x100

 Operating conditions: Showa Denko Shodex SB-802 HQ, a column packed with polyhydroxymethacrylate resin, detection: 265 nm, eluent: H2KPO4 0.03 mol / 1 (pH 2PO4 adjusted to pH 6), column temperature: 65 ° C. The flow rate was measured under the condition of 1.2 ml / min.

(Standard product creation)
30 g of 3-glyceryl-2-octyl ASA (Amitose OGA manufactured by Seiwa Kasei Co., Ltd.) was dissolved in 1000 ml of ion-exchanged water, and 2000 ml of 99.5% ethanol was gradually added with stirring and allowed to stand for 6 hours. Thereafter, the produced crystals are collected by filtration, dissolved again in 1000 ml of ion-exchanged water, 2000 ml of 99.5% ethanol is gradually added with stirring and left to stand for 6 hours, and then the produced crystals are collected by filtration. This crystal was spread on a petri dish and dried under reduced pressure at 35 ° C. and 50 mmHg until the water content measured by the Karl Fischer method was 10% or less, and this was used as a standard product of 2-O-3-G-ASA. As a standard product of monoglyceryl ASA, a general sale product (Amitose 2GA manufactured by Seiwa Kasei Co., Ltd.) was prepared in the same manner as the standard product of 2-O-3-G-ASA described above. ASA of Japanese Pharmacopoeia was used as the standard product for L-ASA.

(HPLC analysis conditions using the area method)
Dissolve 2-O-3-G-ASAO.01 g in 100 ml of water to make the test solution. Using a column packed with polyhydroxymethacrylate resin, 10 μl of the test solution was detected at 265 nm, eluent: H2KPO4 0.03 mol / 1, column temperature: 65 ° C., flow rate: 1.2 ml / min, peak of Gly-Oct-ASA The peak areas B other than the area A and Gly-Oct-ASA were measured by the automatic integration method, and the average results are summarized in Table 4. The standard Gly-Oct-ASA described above was used.

The analysis results by IR (infrared absorption spectrum) were as follows. (cm-1): 3368, 2855, 1751, 1676

The analysis results by NMR (nuclear magnetic resonance spectroscopy) were as follows.
1H-NMR (600MHz, CD3OD) δppm 0.90 (3H, t), 1.32 (8H, m), 1.42 (2H, m), 1.70 (2H, m), 3.60 (2H, brd), 3.65 (2H, m) , 3.89 (1H, m), 3.91 (1H, m), 4.02 (1H, m), 4.47 / 4.48 (1H, dd), 4.57 / 4.59 (1H, dd), 4.86 (1H, d)

13C-NMR (150MHz, CD3OD) δppm l4.4,23.7,26.9,30.37,30.44,30.8,33.0,63.2,63.56,63.59,70.5,70.6,71.5,71.6,74.01,74.04,74.1,76.7,123.27,123.30 , 159.2,159.3,172.2

(ESR measurement conditions)
In a solution of sodium chloride (137 mmol), potassium chloride (2.7 mmol), disodium hydrogen phosphate (10 mmol), and potassium dihydrogen phosphate (1.7 mmol) in purified water, ASA of the Japanese Pharmacopoeia as a standard product. (0.1 mmol) or conventional 2-G-3-O-ASA (hereinafter referred to as comparative product) or conventional 2-O-3-G-ASA (hereinafter referred to as comparative product) ), Or the high purity 2-G-3-O-ASA or 2-O-3-G-ASA of the present invention produced in Example 1 and Example 4 at a concentration of 10 mmol each. To dissolve separately. Further, 0.1 mmol of hemoglobin and 10 mmol of hydrogen peroxide were added thereto, and DMPO (5,5-dimethyl-1-pyrroline-N-oxide having the same weight as the phosphate buffered saline was added. ) And the peak of the ASA radical is detected with an electron spin resonance (hereinafter abbreviated as ESR) measuring device under the following conditions within 3 minutes and the height of the peak is measured.

(ESR measuring equipment conditions)
ESR measuring apparatus conditions were measured by the method of the present inventors Ito (S. Ito, et. Al, Toxicology, vol. 30, no. 1-2, pp. 96-110, 2007.). That is, the type of ROS was identified from the g-value and hfcc of the adduct signal specific to the radical and the wrapping agent detected by the generation of standard active oxygen. The intensity of the spectrum was derived by measuring the height of the spectrum. The radicals and wrapping agents used are as follows. 5- (diphenylphosphinoyl) -5-methyl-4,5-dihydr-O-3H-pyrrole-N-oxide (DMPO). The relative intensity ratio of radicals was calculated by comparison with the third MnO signal intensity. Measuring equipment: ESR (ESR) spectrometer (JEOL, JES-FA200 spectrometer, Tokyo. ESR universal cavity (JEOL, ES-UCX2: TE011 mode cavity) X-band microwave unit (8.750-9.650 GHz) MnO uses ESR standard based on JEOL DATUM (MO7-FB-4) Sample cell (JEOL, ES-LC12); Sample volume: 10-100μl.Tissue type: Uses quartz cell (manufactured by Labotech, Tokyo) Cover glass (40x5x0.5mm) In order to identify ESR spectrum peak of ASA radical, g-value and hfcc were used as standard reagent using ASA of Japanese Pharmacopoeia and incorporated into ESR device Spectral peak heights were automatically calculated by dedicated analysis software (ESR computer software, A-System vl.40 ISAJ, FA-Manager vl.20, JES, Tokyo, Japan) The average value measured in the same manner is shown in Table 5. As a result, the 2-AS-3-O-ASA of the present invention and 2-O-3-G-ASA of the present invention were compared with the ASA radical of the comparative product. While the intensity was 50% or more, it was confirmed that the amount of ASA radicals generated in the present invention was extremely small, 50% or less, and Table 5 shows the relative height of the ascorbic acid radical peak by ESR. The ratio (%).

 Using the same measurement method, 10 mmol of other ASA derivatives, 2-G-3-O-ASA of the present invention and 10 mmol of 2-O-3-G-ASA of the present invention, and ASA radical of 10 mmol of ASA of the Japanese Pharmacopoeia as standard products are measured. The average values of the results are summarized in Table 6. From this result, the present invention was compared with the existing ASA derivative 2-phosphate ASA-2-phosphate Mg, 2-phosphate ASANa, 2-phosphate-6-palmitate ASANa as high as 50% or more. It was revealed that the amount of ASA radicals of 2-G-3-O-ASA and 2-O-3-G-ASA was 50% or less and was extremely suppressed. Table 6 shows the ratio (%) of the relative height of the ascorbic acid radical peak by ESR.

 In a solution of sodium chloride (137 mmol), potassium chloride (2.7 mmol), disodium hydrogen phosphate (10 mmol), and potassium dihydrogen phosphate (1.7 mmol) used in this effect test in purified water, The water-soluble composition in which 2-G-3-O-ASA or 2-O-3-G-ASA of high purity according to the present invention is dissolved at a concentration of 10 mmol is used for pharmaceuticals, quasi drugs, cosmetics, etc. This is an example of the composition for external use and oral composition for food, feed, health food and beverage. In addition, this water-soluble composition is an example of industrial products, civil engineering greening supplies, fertilizers, cleaning materials, agricultural and forestry supplies, horticultural supplies, culture compositions, animal drugs, photosensitive materials, water treatment agents, and air purification agents. But there is. Furthermore, 1% by mass of this water-soluble composition is sprayed on chemical products, powder products, clothing products, granule products, miscellaneous goods, paints, and is contained in chemical products, powder products, clothing products, granule products, miscellaneous goods, paints. These products are examples of the present invention of chemical products, powder products, clothing products, granule products, general goods, paints.

(Color and odor change over time)
In a solution of sodium chloride (137 mmol), potassium chloride (2.7 mmol), disodium hydrogen phosphate (10 mmol), and potassium dihydrogen phosphate (1.7 mmol) in purified water, ASA of the Japanese Pharmacopoeia as a standard product. (0.1 mmol) 2-phosphate ASA-6-palmitate Na (comparative product) 10 mmol, 2-phosphate ASANa (comparative product) 10 mmol, or conventional 2-G-3-O-ASA (Comparative product)), or conventional 2-O-3-G-ASA (comparative product), or the high purity 2-G-3-O-ASA (test product) of the present invention, or 2-O-3-G-ASA (test article) is dissolved separately at a concentration of 10 mmol each. Each was placed in a 20 ml screw bottle and stored for 6 months in an environment of 40 ° C. ± 2 ° C. and humidity of 75% RH ± 5% RH, and the color and odor changes were measured by the following measurement methods. . To change the color tone, a 20 ml screw bottle was photographed with the same illumination with a white screen backed by a digital camera, and the image was automatically calculated by a computer to calculate the L value of the lightness at the center of the screw bottle. Since the L value is an indicator of lightness, it decreased as the color of the solution browned. Table 7 summarizes the results of calculating the brightness after 6 months with the brightness at the start as 100%.

 The odor was scored by a 5-stage fall evaluation based on the following criteria based on the sensitivity evaluation of 10 observers. No odor: 4 points, faint odor: 3 points, low odor: 2 points, moderate odor: 1 point, severe odor: 0 points. As a result, the scores of 10 people were totaled, and the state after 6 months was summarized in Table 7 with the starting time being 100%. From these results, the 2-G-3-O-ASA and 2-O-3-G-ASA of the present invention are ASA and the conventional ASA derivative 2-phosphate ASANg (comparative product) and 2-phosphorus. Compared to acid ASA-6-palmitate Na (comparative product), changes in color and odor are dramatically improved. Furthermore, 2-G-3-O-ASA (comparative product) and 2-O- A clear improvement was confirmed even when compared with 3-G-ASA (comparative product). Table 7 shows the deterioration of the color tone and odor and its suppression effect.

 The high purity Gly-Oct-ASA of the present invention comprising 2-G-3-O-ASA or 2-O-3-G-ASA marked as the product of the invention used in all the following examples Is a liquid chromatogram conducted under the same conditions as described above, and the total content of ASA selected from monoglyceryl ASA and monooctyl ASA is 3% by mass or less, and Gly When measuring the peak area of -Oct-ASA and the peak area other than Gly-Oct-ASA by the automatic integration method of the liquid chromatogram, the peak area other than Gly-Oct-ASA was less than 5% of the total peak area. It was. Further, when the ASA radical intensity was measured as the peak height under the same conditions as in Example 7, the ASA radical intensity of Gly-Oct-ASA was 50% or less of the ASA radical intensity generated by the same mole of ASA. .

 In addition, Gly-Oct-ASA including 2-G-3-O-ASA or 2-O-3-G-ASA, which is used in all of the following examples, is described as a conventional product or a comparative product. The total of the content of ASA and one kind selected from monoglyceryl ASA and monooctyl ASA by a liquid chromatogram test conducted under the same conditions as described above is 3.1% by mass or more, and When measuring the peak area of Gly-Oct-ASA and the peak area other than Gly-Oct-ASA by the liquid chromatogram automatic integration method, the peak area other than Gly-Oct-ASA is 5.1 of the total peak area. % Or more. Furthermore, when the ASA radical intensity was measured as the peak height under the same conditions as in Example 7, the ASA radical intensity of Gly-Oct-ASA was 51% or more of the ASA radical intensity generated by the same mole of ASA. .

(Erythema inflammation test using human)
Erythema inflammation caused by ultraviolet rays in skin coating agents in which 1% of ascorbic acid-related compositions shown in Table 8 (all percentages shown below are by weight), glycerin 10% and purified water 89% are uniformly mixed Inhibition studies were performed on adult subjects. Subjects applied the test composition twice a day in the morning and evening for 4 days, and on the first day of UV irradiation, applied to the irradiated area (0.5 g / 1 cm 2) 2 hours before irradiation. It was done. The irradiation ultraviolet rays used were a 2500 W OSRAM xenon lamp through a UVB cut filter and an infrared cut filter. Irradiation was performed once on the first day. Each subject's minimum erythema-irradiation dose (MED) due to ultraviolet rays was measured on the day before the start of the test, 1.5M of ultraviolet rays was irradiated on the first day of the test, and UV irradiation was not performed on and after the second day. Only the object was applied. The test composition was compared with a placebo by visual evaluation based on SPF, and the redness (a value) of the skin was measured using a Minolta Lab color difference meter on the fourth day from the day of ultraviolet irradiation for the suppression rate of erythema inflammation. . The suppression rate of erythema inflammation (%) was calculated by the following formula in comparison with placebo.
[(Inhibition by test composition-inhibition by plateo) / (inhibition by plateo)] x 100 = rate of inhibition of erythema inflammation (%)
From these results, the 2-G-3-O-ASA, 2-O-3-G-ASA of the present invention is a conventional 2-phosphate-6-palmitate ASANa, 2-G-3-O, which is a comparative product. As compared with -ASA and existing ASA and 2-0-phosphate ASAMg, 2-phosphate ASANa, and 2-phosphate-6-palmitate ASANa, it was confirmed that the erythema inflammation suppression rate was significantly increased.

(Relationship between impurity amount, ASA radical strength, erythema suppression rate)
About the skin coating agent of Example 9, 3-O-octyl-2-O-glyceryl ascorbic acid (product of the present invention) added as an ascorbic acid-related composition, 3-O-glyceryl-2-O-octyl ascorbic acid (Invention product) and 3-O-octyl-2-O-glyceryl ascorbic acid (comparative product), 3-O-glyceryl-2-O-octyl ascorbic acid (comparative product), the above-mentioned Examples and Implementations The total content of monoglyceryl ascorbine and ASA (%) and the peak area ratio (%) other than Gly-Oct-ASA, measured by the same HPLC method as in Example 2 and Example 5, The relationship between the ASA radical and the rate of suppression of erythema inflammation caused by UV irradiation, measured by the same ESR method as in Example 7, was examined using adult volunteers. The results are shown in FIGS. FIG. 1 is a graph showing the relationship between the total content of monoglyceryl ASA and ASA by the HPLC method, the ascorbic acid radical strength by the ESR method, and the suppression rate of erythema inflammation by ultraviolet irradiation.

(FIG. 1) The figure which showed the relationship between the sum total of content of monoglyceryl ascorbine and ascorbic acid by HPLC method, the ascorbic acid radical intensity | strength by ESR method, and the erythema inflammation suppression rate by ultraviolet irradiation. (Example 10)

(FIG. 2) The figure which showed the relationship between the peak area other than glyceryl octyl ascorbic acid by HPLC method, the ascorbic acid radical intensity | strength by ESR method, and the erythema inflammation suppression rate by ultraviolet irradiation. (Example 10)

The figure which showed the relationship between the peak area other than glyceryl octyl ascorbic acid by HPLC method, the ascorbic acid radical intensity | strength by ESR method, and the erythema inflammation suppression rate by ultraviolet irradiation.
In the figure, the horizontal axis is the index of impurities used in the preparation, and the horizontal axis in FIG. 1 is the total content of monoglyceryl ASA and ASA, which is the embodiment of claim 1, and the horizontal axis in FIG. Is the ratio of the peak area other than glyceryl octyl ASA, which is an embodiment of claim 2.
The vertical axis shows the erythema inflammation suppression rate (%) on the left side and the ASA radical intensity (%) measured by ESR of ASA octylglyceryl used in the formulation on the right side. The suppression rate of erythema inflammation is indicated by a square character (□). ASA radical strength is indicated by diamond-shaped characters (◇).

 From this result, it is confirmed that the product of the present invention of claim 1 (the total content of monoglyceryl ASA and ASA is 3% or less) suppresses the ASA radical strength and improves the erythema inflammation suppression rate compared to the comparative product. It was done. This is an example of the action for improving erythema of the claimed skin.

The product of the present invention as defined in the claims (glyceryl octyl ASA peak area and glyceryl octyl ASA containing at least one selected from 2-G-3-O-ASA and 2-O-3-G-ASA) As shown in FIG. 2, the peak area other than glyceryl octyl ASA is 5% or less of the total peak area when the peak area other than is measured by the liquid chromatogram automatic integration method. Similarly, it was clearly confirmed that the suppression rate of erythema inflammation was improved as compared with the comparative product, and the ASA radical intensity was suppressed on the contrary.

 Further, when attention is paid to the radical strength (diamond character) in FIG. 1, the ASA radical strength of the comparative product (the total content of monoglyceryl ascorbine and ASA is 3% by mass or more) is 40% or more. The ASA radical strength of the present invention product is an embodiment of the claims of the present invention, which is less than half (50% or less) when the comparative product is 100%. The glyceryl octyl ASA of the present invention claims This is evidence that it is an ASA derivative that hardly generates ASA radicals.

From this result, the product of the present invention has an improved erythema inflammation suppression rate compared to the comparative product when the concentration (mass%) of the derivative other than ASA octylglyceryl is 5% or less, and the ASA radical strength measured by ESR is conversely It was clearly confirmed that it was suppressed.

The 2-G-3-O-ASA or 2-O-3-G-ASA used below was all confirmed to satisfy the conditions of Examples 1 to 3, and the high Only raw materials that were confirmed to correspond to the purity glyceryl octyl ASA were used.
Hereinafter, although a formulation example is shown, the numerical value shown unless otherwise explained is mass%.

A solution was prepared according to the following formulation.
(Liquid composition 1)
Example 1 and Example 4 were prepared by adding sodium chloride (137 mmol), potassium chloride (2.7 mmol), disodium hydrogen phosphate (10 mmol), and potassium dihydrogen phosphate (1.7 mmol) in purified water. The liquid composition used in Example 7 to which 10 mmol of high purity 2-G-3-O-ASA of the present invention produced or 10 mmol of 2-O-3-G-ASA was added.
This prescription is an example of a solution for external application for pharmaceuticals, quasi-drugs, medical cultures, medical devices, medical devices, unapproved pharmaceuticals, cosmetics, and animal products.
Furthermore, an oral composition (this agent was sterilized with a membrane filter to obtain an ASA radical-inhibited beverage for humans and animals) and an in-vivo composition (this agent was sterilized with a membrane filter to obtain an ASA radical inhibitor for internal organs). ), Formulation of a chemical product (used as an antioxidant spray solution for factories).
(Liquid composition 2)
The high-purity 2-G-3-O-ASA of the present invention produced by the same method as that produced in Example 1 and Example 4 and confirmed impurities and ASA radicals by the test methods of Examples 5 to 7 : 1, or 2-O-3-G-ASA: 1. A skin coating agent in which glycerin 10 and purified water: 89 are uniformly mixed.
This prescription is an example of a solution for external application for pharmaceuticals, quasi-drugs, medical cultures, medical devices, medical devices, unapproved pharmaceuticals, cosmetics, and animal products.
Furthermore, the composition for oral use (this agent was sterilized with a membrane filter to make an ASA radical-inhibited beverage for humans and animals), and the composition for internal use (this agent was sterilized with a membrane filter to give an ASA radical inhibitor for internal organs). ), A chemical formulation (used as an indoor antioxidant spray solution).
(Liquid composition 3)
2-G-3-O-ASA: 1, or 2-O-3-G-ASA: 1, glycerin: 6.5, 1,3-butylene glycol: 1.0, phenoxyethanol: 0.5, Fragrance complex: 0.1, purified water: remaining amount.
This prescription is an example of a solution for external application for pharmaceuticals, quasi-drugs, medical cultures, medical devices, medical devices, unapproved pharmaceuticals, cosmetics, and animal products.
Furthermore, the composition for oral use (this agent was sterilized with a membrane filter to make an ASA radical-inhibited beverage for humans and animals), the composition for the body (this agent was sterilized with a membrane filter to make an ASA radical inhibitor for internal organs of animal animals) .) Is an example of the formulation of a chemical product (used as an indoor antioxidant spray solution).
More specifically, it can be used as an external preparation of the following form. That is, the form of the external preparation that can be used in this formulation is shampoo, rinse, treatment, hair pack, hair spray, hair mist, lotion, toner, essence, hair restorer, facial cleanser, cleansing lotion, lotion, emollient lotion, moisture lotion, Milky Lotion, Nourishing Lotion, Skin Moisture Lotion, Moisture Emulsion, Massage Lotion, Cleansing Lotion, Sun Protect, Sun Protector, Sunscreen, Makeup Lotion, Horny Smoother, Elbow Lotion, Hand Lotion, Body Lotion, Liquid Soap, Pack , Mask, moisturizing essence, whitening essence, UV protection essence, skin care basic cosmetic, makeup agent, skin perfume, puff Over-time, parfum, eau de parfum, eau de toilette, eau de cologne, kneading perfume, deodorant lotion, deodorant powder, deodorant spray, deodorant cosmetics, bath preparation, body skin for the agent.

(Liquid composition)
2-G-3-O-ASA: 1.0, or 2-O-3-G-ASA: 1.0, glycerin: 6.5, 1,3-butylene glycol: 1.0, phenoxyethanol: 0.5, perfume complex: 0.1, purified water: remaining amount.
This formulation is an emollient lotion, elbow lotion, color lotion, cleansing lotion, set lotion, deodorant lotion, toner, nourishing lotion, hand lotion, body lotion, massage lotion, makeup lotion, moistur lotion, lotion, essence, whitening essence, eau de cologne Examples of eau de toilette moisture essence and hair restorer.
This prescription is an example of a solution for external application for pharmaceuticals, quasi-drugs, medical cultures, medical devices, medical devices, unapproved pharmaceuticals, cosmetics, and animal products.
Furthermore, the composition for oral use (this agent was sterilized with a membrane filter to make an ASA radical-inhibited beverage for humans and animals), and the composition for internal use (this agent was sterilized with a membrane filter to give an ASA radical inhibitor for internal organs). ), A chemical formulation (used as an indoor antioxidant spray solution).

(Liquid composition)
2-G-3-O-ASA: 1.0, or 2-O-3-G-ASA: 1.0, Glycerin: 6.5, 1,3-butylene glycol: 10.0, Phenoxyethanol: 0.5, perfume complex: 0.1, purified water: remaining amount.
This formulation is an emollient lotion, elbow lotion, color lotion, cleansing lotion, set lotion, deodorant lotion, toner, nourishing lotion, hand lotion, body lotion, massage lotion, makeup lotion, moistur lotion, lotion, essence, whitening essence, eau de cologne An example of an eau de toilette moisture essence.
This prescription is an example of a solution for external application for pharmaceuticals, quasi-drugs, medical cultures, medical devices, medical devices, unapproved pharmaceuticals, cosmetics, and animal products.
Furthermore, the composition for oral use (this agent was sterilized with a membrane filter to make an ASA radical-inhibited beverage for humans and animals), and the composition for internal use (this agent was sterilized with a membrane filter to give an ASA radical inhibitor for internal organs). ), A chemical formulation (used as an indoor antioxidant spray solution).

(Liquid composition)
2-G-3-O-ASA: 0.1, or 2-O-3-G-ASA: 0.1, Sodium glutamate: 2.0, Ethanol: 60.0, Pepper tincture: 0.5, Aloe Extract: 3.0, dipotassium glycyrrhizinate: 0.5, arginine 0.2, antibacterial agent: 0.7, purified water: remaining amount.
This was used as a hair growth solution and a tonic.
This formula is for hair growth liquid, hair growth tonic, emollient lotion, elbow lotion, color lotion, cleansing lotion, set lotion, deodorant lotion, toner, nourishing lotion, hand lotion, body lotion, massage lotion, makeup lotion, moisture lotion, Examples of hair growth liquids such as lotion, essence, whitening essence, eau de cologne, eau de toilette moisture essence.
This prescription is an example of a solution for external application for pharmaceuticals, quasi-drugs, medical cultures, medical devices, medical devices, unapproved pharmaceuticals, cosmetics, animal products, and pet hair restorers.
Furthermore, it is an Example of the formulation of the chemical | medical agent (it was set as the liquid medicine for the hair growth spray of a pet towel).

(Liquid emulsion composition)
2-G-3-O-ASA: 1.0, or 2-O-3-G-ASA: 1.0, polyoxyethylene (10E.O.) sorbitan: 1.0, monostearate: 0.5, polyoxyethylene (60E.O.), sorbit: 0.5: tetraoleate: 0.5, glyceryl monostearate: 1.0, behenyl alcohol: 0.5, squalane: 8.0, carboxy Vinyl polymer: 0.1, sodium hydroxide: 0.05, ethyl alcohol: 5.0, purified water: remaining amount, phenoxyethanol: 0.7, fragrance: 0.01
This formula is an example of UV care milk, cleansing milk, nourishing milk, protective emulsion, milky lotion, milk, moisturizer emulsion, milky lotion, hair growth milky lotion.
This prescription is an example of a solution for external application for pharmaceuticals, quasi-drugs, medical cultures, medical devices, medical devices, unapproved pharmaceuticals, cosmetics, and animal products.
Furthermore, it is an Example of the formulation of the chemical | medical agent product (this formulation is diluted 10 times with purified water to make an indoor antioxidant spray emulsion).

(Emulsified composition)
2-G-3-O-ASA: 1.0, or 2-O-3-G-ASA: 1.0, stearic acid: 2.0, cetanol: 1.0, polyoxyethylene monooleate Sorbitan (20E.O.): 0.5, sorbitan sesquioleate: 0.5, cetyl 2-ethylhexanoate: 12.0, shea butter: 2.0, jojoba oil: 1.0, paramethoxy cinnamon 2-ethylhexyl acid * 7: 8.0, 2-hydroxy-4-methoxybenzophenone * 8: 2.0, 1,3-butylene glycol: 10.0, carboxyvinyl polymer: 0.2, purified water: remaining amount , Phenoxyethanol: 0.7, Titanium oxide: 3.0, Triethanolamine: 0.5. Fragrance: 0.01
This formula is an example of UV care milk, cleansing milk, nourishing milk, protective emulsion, milky lotion, milk, moisturizer emulsion, milky lotion, hair growth milky lotion.
This prescription is an example of a solution for external application for pharmaceuticals, quasi-drugs, medical cultures, medical devices, medical devices, unapproved pharmaceuticals, cosmetics, and animal products.
Further, this formulation was diluted 10 times with purified water to obtain an indoor spray spray for antioxidants. Thus, they also serve as examples of chemical products.

(Flowable composition)
2-G-3-O-ASA: 0.001, or 2-O-3-G-ASA: 0.001, Lanolin: 7.0, Liquid paraffin: 5.0, Stearic acid: 2.0 , Cetanol: 1.0, sunflower oil: 1.0, glycerin: 5.0, triethanolamine: 1.0, carboxymethylcellulose: 0.7, mica: 15.0, talc: 6.0, titanium oxide: 3.0, coloring pigment: 6.0, phenoxyethanol: 0.5, fragrance: 0.01, purified water: remaining amount.
This prescription is an example of a solution for external application for pharmaceuticals, quasi-drugs, medical cultures, medical devices, medical devices, unapproved pharmaceuticals, cosmetics, and animal products.
Furthermore, it is an example of the formulation of a chemical solution of the chemical product (this formulation is diluted 10-fold with purified water to obtain a UV-cut antioxidant spray emulsion for glass).
This formula is an example of UV care milk, cleansing milk, nourishing milk, protective emulsion, milky lotion, milk, moisturizer emulsion, milky lotion, hair growth milky lotion.

(Liquid emulsion formulation)
2-G-3-O-ASA: 1.0, or 2-O-3-G-ASA: 1.0, polyoxyethylene (10E.O.) sorbitan: 1.0: Monostearate: 0.5, polyoxyethylene (60E.O.) sorbit: 0.5: tetraoleate: 0.5, glyceryl monostearate: 1.0, 2-G-3-O-ASA: 0.1, Behenyl alcohol: 0.5, squalane: 8.0, purified water: remaining amount This formulation is for pharmaceuticals, quasi-drugs, medical cultures, medical devices, medical devices, unapproved pharmaceuticals, cosmetics, animal products It is an Example of the liquid agent for external application | coating.
Furthermore, this formulation is diluted 10-fold with purified water, cleaning solution for cleaning products, processing agent for general goods, processing agent for clothing, anti-discoloration agent, stabilizer, household antioxidant, odor eliminating agent, household adhesive, Industry including industrial antioxidants, industrial reducing agents, water treatment agents, air purification agents, photosensitive materials, industrial discoloration inhibitors, industrial stabilizers, industrial antioxidants, industrial adhesives, deodorants, etc. Supplies, civil engineering green supplies, paints, antioxidants for buildings, anti-degradants for buildings, tape treatments for humans for sports, coolants for sports, adhesives for skin, liquid cleaners for furniture, and cleaners for jewelry Examples of decorative cleaner liquid, human body paint thinning liquid, stocking spray liquid, underwear spray liquid, and mask spray liquid were used. The purpose of these uses is to increase the antioxidant power of the chemical product by applying or treating it to the chemical product, thereby providing durability. These also serve as examples of chemical products.
This formula is an example of cleansing milk, nourishing milk, protective emulsion, milky lotion, milk, moisturizer emulsion, milky lotion, hair growth milky lotion.

(Emulsified composition)
2-G-3-O-ASA: 1.0, or 2-O-3-G-ASA: 1.0, stearic acid: 18.0, cetanol: 4.0, triethanolamine: 1. 0, N, N'-diacetylcystine dimethyl: 0.01, phenoxyethanol: 0.7, purified water: remaining amount This formula is emollient cream, cream, cleansing cream, suntan cream, shaving cream, deodorant cream, night cream, nari Thing cream, burnishing cream, pre-makeup cream, hair cream, base cream, massage cream, makeup cream, moisture cream, keratin softening cream, hair removal cream.
This prescription is an example of a solution for external application for pharmaceuticals, quasi-drugs, medical cultures, medical devices, medical devices, unapproved pharmaceuticals, cosmetics, and animal products.
Furthermore, this formulation is diluted 10-fold with purified water, cleaning solution for cleaning products, processing agent for general goods, processing agent for clothing, anti-discoloration agent, stabilizer, household antioxidant, odor eliminating agent, household adhesive, Industry including industrial antioxidants, industrial reducing agents, water treatment agents, air purification agents, photosensitive materials, industrial discoloration inhibitors, industrial stabilizers, industrial antioxidants, industrial adhesives, deodorants, etc. Supplies, civil engineering green supplies, paints, antioxidants for buildings, anti-degradants for buildings, tape treatments for humans for sports, coolants for sports, adhesives for skin, liquid cleaners for furniture, and cleaners for jewelry Examples of decorative cleaner liquid, human body paint thinning liquid, stocking spray liquid, underwear spray liquid, and mask spray liquid were used. The purpose of these uses is to increase the antioxidant power of the chemical product by applying or treating it to the chemical product, thereby providing durability. These also serve as examples of chemical products.

(Emulsified composition)
2-G-3-O-ASA: 0.005, or 2-O-3-G-ASA: 0.005, stearic acid: 18.0, cetanol: 4.0, triethanolamine: 0, purified water: remaining amount

(Emulsified composition)
2-G-3-O-ASA: 10.0, or 2-O-3-G-ASA: 10.0, polyoxyethylene (40E.O.) monostearate: 2.0, glycerin mono Stearate (self-emulsifying type): 5.0, stearic acid: 5.0, behenyl alcohol: 0.5, squalane: 15.0, cetyl isooctanoate: 5.0, 1,3-butylene glycol: 5.0, 2-ethylhexyl paramethoxycinnamate: 5.0, phenoxyethanol: 0.7, fragrance: 0.01,
Purified water: remaining amount,
This prescription is an example of a solution for external application for pharmaceuticals, quasi-drugs, medical cultures, medical devices, medical devices, unapproved pharmaceuticals, cosmetics, and animal products.
Furthermore, this formulation is diluted 10-fold with purified water, cleaning solution for cleaning products, processing agent for general goods, processing agent for clothing, anti-discoloration agent, stabilizer, household antioxidant, odor eliminating agent, household adhesive, Industry including industrial antioxidants, industrial reducing agents, water treatment agents, air purification agents, photosensitive materials, industrial discoloration inhibitors, industrial stabilizers, industrial antioxidants, industrial adhesives, deodorants, etc. Supplies, civil engineering green supplies, paints, antioxidants for buildings, anti-degradants for buildings, tape treatments for humans for sports, coolants for sports, adhesives for skin, liquid cleaners for furniture, and cleaners for jewelry Examples of decorative cleaner liquid, human body paint thinning liquid, stocking spray liquid, underwear spray liquid, and mask spray liquid were used. The purpose of these uses is to increase the antioxidant power of the chemical product by applying or treating it to the chemical product, thereby providing durability. These also serve as examples of chemical products.

(Gel emulsion)
2-G-3-O-ASA: 10.0, or 2-O-3-G-ASA: 10.0, carboxyvinyl polymer: 1.0, triethanolamine: 1.0, 1, 3 -Butylene glycol: 10.0, 2-G-3-O-ASA: 1.0, 2-hydroxy-4-methoxybenzophenone-5 sodium sulfate: 3.0, purified water: remaining amount, phenoxyethanol: 0.0. 7. Purified water: remaining amount This formula is UV care milk, cleansing milk, nourishing milk, sunscreen cream, protect emulsion, sunscreen, sun protector, sun protect: milky lotion, milk, moisturizer emulsion, milky lotion, hair growth It is an example of an emulsion.
This prescription is an example of a solution for external application for pharmaceuticals, quasi-drugs, medical cultures, medical devices, medical devices, unapproved pharmaceuticals, cosmetics, and animal products.
Furthermore, this formulation is diluted 10-fold with purified water, cleaning solution for cleaning products, processing agent for general goods, processing agent for clothing, anti-discoloration agent, stabilizer, household antioxidant, odor eliminating agent, household adhesive, Industry including industrial antioxidants, industrial reducing agents, water treatment agents, air purification agents, photosensitive materials, industrial discoloration inhibitors, industrial stabilizers, industrial antioxidants, industrial adhesives, deodorants, etc. Supplies, civil engineering green supplies, paints, antioxidants for buildings, anti-degradants for buildings, tape treatments for humans for sports, coolants for sports, adhesives for skin, liquid cleaners for furniture, and cleaners for jewelry Examples of decorative cleaner liquid, human body paint thinning liquid, stocking spray liquid, underwear spray liquid, and mask spray liquid were used. The purpose of these uses is to increase the antioxidant power of the chemical product by applying or treating it to the chemical product, thereby providing durability. These also serve as examples of chemical products.

(Gel agent)
2-G-3-O-ASA: 0.1, or 2-O-3-G-ASA: 0.1, carboxyvinyl polymer: 1.0, triethanolamine: 1.0, 1, 3 -Butylene glycol: 10.0, 2-hydroxy-4-methoxybenzophenone-5-sodium sulfate: 3.0, purified water: remaining amount

(Coating agent)
2-G-3-O-ASA: 0.1, or 2-O-3-G-ASA: 0.1, polyvinyl alcohol: 20.0, ethyl alcohol: 20.0, glycerin: 5.0 , Kaolin: 6.0, phenoxyethanol: 0.2, fragrance: 0.1, purified water: remaining amount

(Cleaning fee)
2-G-3-O-ASA: 0.1, or 2-O-3-G-ASA: 0.1, stearic acid: 10.0, palmitic acid: 8.0, myristic acid: 12. 0, lauric acid: 4.0, oleyl alcohol: 1.5, purified lanolin: 1.0, fragrance: 0.1, phenoxyethanol: 0.2, glycerin: 18.0, purified water: remaining amount

(Oil composition)
An oil preparation was prepared according to the following formulation.
(Prescription) (%)
Jojoba oil: 49, 2-G-3-O-ASA: 0.01 or 2-O-3-G-ASA: 0.01, olive oil: remaining amount
The above formulation could also be used with remover oil, moisturizing oil, bath oil, hair oil, body oil, face oil, nail oil.
This prescription is an example of a solution for external application for pharmaceuticals, quasi-drugs, medical cultures, medical devices, medical devices, unapproved pharmaceuticals, cosmetics, and animal products.
In addition, this prescription is used for miscellaneous goods oils, clothing oils, anti-discoloration oils, household antioxidant oils, odor eliminating oils, industrial antioxidant oils, air purification filter oils, industrial Anti-discoloring oil agent, industrial antioxidant oil agent, deodorizing oil agent, water-based paint thinning solution, architectural antioxidant oil agent, building anti-degradation oil agent, shoe oil oil agent, bathroom oil agent, wallpaper Examples of protective oil agents, furniture oil agents, accessory protection oil agents, decorative oil agents, stocking oil agents, underwear oil agents, and mask oil agents. The purpose of these uses is to treat the chemical product with this oil agent to increase the antioxidant power of the chemical product and make it durable. These also serve as examples of chemical products.

(Emulsified composition)
2-G-3-O-ASA: 0.1 or 2-O-3-G-ASA: 0.1, polyoxyethylene (40E.O.) monostearate: 2.0, glycerin monostearate (Self-emulsifying type) 1: 5.0, stearic acid: 5.0, behenyl alcohol: 0.5, squalane: 15.0, cetyl isooctanoate: 5.0, 1,3-butylene glycol: 5.0, para 2-ethylhexyl methoxycinnamate: 5.0, phenoxyethanol: 0.7, purified water: remaining amount This formulation is emollient cream, cream, cleansing cream, suntan cream, shaving cream, deodorant cream, night cream, nourishing cream, Vanishing cream, Pre-makeup cream, Hair cream, Base cream, Massage cream, Makeup cream, Moi Char cream, horny softening cream, is an example of a hair removal cream.

(Powder)
2-G-3-O-ASA: 0.1, or 2-O-3-G-ASA: 0.1, Lanolin: 7.0, Liquid paraffin: 5.0, Stearic acid: 2.0 , Cetanol: 1.0, sunflower oil * 1: 1.0, glycerin: 5.0, triethanolamine: 1.0, carboxymethylcellulose: 0.7, mica: 15.0, talc: 6.0, oxidation Titanium: 3.0, Color pigment: 6.0, Phenoxyethanol: 0.7, Phenoxyethanol: 0.5 Fragrance: 0.01, Purified water: Remaining amount,
The above preparations are examples of foundation, deodorant powder, body powder, wash powder, deodorant powder, eye shadow, eyebrow, eyeliner and body powder.
This prescription is an example of an external cleaning solution for pharmaceuticals, quasi drugs, medical cultures, medical devices, medical devices, unapproved pharmaceuticals, cosmetics, and animal products.
This prescription is a powder for general goods, a powder for clothing, a discoloration-preventing powder, a household antioxidant powder, an odor-eliminating powder, an industrial antioxidant powder, an air purification filter powder, an industrial discoloration-preventing powder, and an industrial antioxidant. Powders, deodorizing powders, water-based paint thinners, anti-oxidation powders for buildings, anti-deterioration powders for buildings, shoe powders, bathroom powders, wallpaper protection powders, furniture powders, accessories protection powders, decorative powders Examples of stocking powder, underwear powder, and mask powder. The purpose of these treatments is to increase the antioxidant power of the chemical product by imparting durability by treating the chemical product with this powder.

(Coating composition)
An external coating preparation was prepared according to the following formulation.
2-G-3-O-ASA: 0.1, or 2-O-3-G-ASA: 0.1, polyvinyl alcohol: 20.0, ethyl alcohol: 20.0, glycerin: 5.0 , Kaolin: 6.0, phenoxyethanol: 0.7, fragrance: 0.1, purified water: remaining amount:
This prescription is an example of a solution for external application for pharmaceuticals, quasi-drugs, medical cultures, medical devices, medical devices, unapproved pharmaceuticals, cosmetics, and animal products.
This formulation consists of sundry film coatings, clothing coatings, anti-discoloration coatings, household antioxidant coatings, odor eliminating coatings, industrial antioxidant coatings, air purification filter coatings, and industrial discoloration. Antioxidant coating agent, industrial antioxidant coating agent, deodorizing coating agent, aqueous paint thinning solution, architectural antioxidant coating agent, architectural deterioration prevention coating agent, sports human body tape coating agent, sports cooling coating Examples of agents, skin coatings, furniture protection coatings, accessories protection coatings, decorative product protection coatings, human body paint thinning liquid, stocking spray liquid, underwear spray liquid, and mask spray liquid. These uses can be applied to or treated on the chemical product to increase the antioxidant power of the chemical product and provide durability.

(Emulsified composition)
2-G-3-O-ASA: 0.5, or 2-O-3-G-ASA: 0.5, stearic acid: 2.0, cetanol: 1.0, polyoxyethylene sorbitan monooleate ( 20E.O.): 0.5, sorbitan sesquioleate: 0.5, cetyl 2-ethylhexanoate: 12.0, 2-ethylhexyl paramethoxycinnamate: 8.0, 2-hydroxy-4-methoxy Benzophenone: 2.0, 1,3-butylene glycol: 10.0, carboxyvinyl polymer: 0.2, purified water: remaining amount, phenoxyethanol: 0.7, titanium oxide: 3.0, triethanolamine: 0.00 5.
The above formulation is an example of UV milk.
This prescription is an example of a solution for external application for pharmaceuticals, quasi-drugs, medical cultures, medical devices, medical devices, unapproved pharmaceuticals, cosmetics, and animal products.
This formulation consists of sundry film coatings, clothing coatings, anti-discoloration coatings, household antioxidant coatings, odor eliminating coatings, industrial antioxidant coatings, air purification filter coatings, and industrial discoloration. Antioxidant coating agent, industrial antioxidant coating agent, deodorizing coating agent, aqueous paint thinning solution, architectural antioxidant coating agent, architectural deterioration prevention coating agent, sports human body tape coating agent, sports cooling coating Examples of agents, skin coatings, furniture protection coatings, accessories protection coatings, decorative product protection coatings, human body paint thinning liquid, stocking spray liquid, underwear spray liquid, and mask spray liquid. These uses can be applied to or treated on the chemical product to increase the antioxidant power of the chemical product and provide durability.

(Washing soap)
2-G-3-O-ASA: 0.1, or -O-3-G-ASA: 0.1, sodium aspartate 1.0, methoxycinnamic acid 1.0, myristic acid 25.0, Stearic acid 5.0, beef tallow fatty acid 5.0, propylene glycol 10.0, potassium hydroxide 6.0, coconut oil fatty acid diethanolamide 6.0, glycerol 1.0, 1, 3-butylene glycol 1.0, phenoxyethanol 0.1, 100 with purified water.
This formulation was used as a skin cleanser, facial cleanser, shampoo, oil shampoo, cream shampoo, conditioning shampoo, shampoo, body shampoo, rinse shampoo.
This prescription is an example of an external cleaning solution for pharmaceuticals, quasi drugs, medical cultures, medical devices, medical devices, unapproved pharmaceuticals, cosmetics, and animal products.
This prescription is for general goods cleaners, clothing cleaners, anti-discoloration cleaners, household antioxidant cleaners, odor eliminating cleaners, industrial antioxidant cleaners, air purification filter cleaners, industrial discoloration Antioxidant cleaner, industrial antioxidant cleaner, deodorant cleaner, water-based paint thinning solution, architectural antioxidant cleaner, architectural deterioration cleaner, shoe cleaner, bathroom cleaner, wallpaper protection Examples of cleaning agents, furniture cleaners, accessory protection cleaners, ornament cleaners, stocking cleaners, underwear cleaners, and mask cleaners. The purpose of these uses is to increase the antioxidant power of the chemical product and to provide durability by washing the chemical product with this cleaning agent.

(Powder)
2-G-3-O-ASA: 0.1, or 2-O-3-G-ASA: 0.1, silicone-treated mica 25.0, sericite 17.0, hydrophobic-treated silica 20.0, oxidation Titanium 20.0, spherical alumina powder 4.0, dimethylpolysiloxane 4.0, methylphenylpolysiloxane 1.0, petrolatum: 3.0, octylmethoxycinnamate 3.0, sorbitan diisostearate 1.0, Antioxidant 0.7, paraoxybenzoic acid 0.7, talc remaining.
This formulation is an example of a skin powder and foundation.
This prescription is an example of an external cleaning solution for pharmaceuticals, quasi drugs, medical cultures, medical devices, medical devices, unapproved pharmaceuticals, cosmetics, and animal products.
This prescription is a powder for general goods, a powder for clothing, a discoloration-preventing powder, a household antioxidant powder, an odor-eliminating powder, an industrial antioxidant powder, an air purification filter powder, an industrial discoloration-preventing powder, and an industrial antioxidant. Powders, deodorizing powders, water-based paint thinners, anti-oxidation powders for buildings, anti-deterioration powders for buildings, shoe powders, bathroom powders, wallpaper protection powders, furniture powders, accessories protection powders, decorative powders Examples of stocking powder, underwear powder, and mask powder. The purpose of these treatments is to increase the antioxidant power of the chemical product by imparting durability by treating the chemical product with this powder.

(Emulsified composition)
2-G-3-O-ASA: 0.05 or 2-O-3-G-ASA: 0.05, sodium glutamate 1.5, octamethylcyclotetrasiloxane 20.0, polyoxyethylene oleyl ether 4.0, polyoxyethylene hydrogenated castor oil 3.0, aluminum monostearate 0.0, 1: liquid paraffin 12.0, dimethylpolysiloxane 5.0, 12-hydroxystearic acid 1.0, nylon powder 4. 5. Titanium oxide 5.0, zinc oxide 2.0, butyl paraoxybenzoate 0.2, sorbitol 7.0, and 100 with purified water.
This formulation is an example of an emulsified external preparation, milk, milk foundation, UV care milk, cleansing milk, nourishing milk, protective emulsion, milky lotion, milk, moisturizer emulsion, milky lotion, and hair growth emulsion.
This prescription is an example of a solution for external application for pharmaceuticals, quasi-drugs, medical cultures, medical devices, medical devices, unapproved pharmaceuticals, cosmetics, and animal products.

(Prescription)
2-G-3-O-ASA: 0.05, or 2-O-3-G-ASA: 0.05, paraffin wax 5.0, ceresin: 5.0, candelilla wax: 2.0, Microcrystalline wax 1.0, 2-G-3-O-ASA: 0.5, or 2-O-3-G-ASA: 0.5, polyethylene wax: 1.0, ethylene propylene copolymer 1.0 Hydrogenated polyisobutene 10.0, diisostearyl malate 15.0, isotridecyl isononanoate 12.0, neopentyl glycol dicaprate 8.0, octyldodecanol 3.0, squalane 5.0, phytosteryl oleate 3 0.0, methylphenylpolysiloxane 3.0, DL-α-tocopherol: 0.1, residual amount of glyceryl trioctanoate. This prescription is an example of preparations for lips, oral and external preparations, lipstick, concealer, and eyeliner.
This prescription is an example of a solution for external application for pharmaceuticals, quasi-drugs, medical cultures, medical devices, medical devices, unapproved pharmaceuticals, cosmetics, and animal products.

2-G-3-O-ASA: 0.5, or 2-O-3-G-ASA: 0.5, potassium citrate 1.5, sodium N-lauroylmethyl taurate 7.0, sodium lauroyl sarcosine 6.0, lauryl dimethyl betaine 2.5, coconut oil fatty acid diethanolamide 4.0, propylene glycol: 5.0, 2-phenoxyethanol 1.0, hydroxyethyl cellulose: 0.5, and 100 with purified water.
This formulation is an example of scalp cleanser, hair shampoo, whole body shampoo, oil shampoo, cream shampoo, conditioning shampoo, shampoo, body shampoo, rinse shampoo.
This prescription is an example of a solution for external application for pharmaceuticals, quasi-drugs, medical cultures, medical devices, medical devices, unapproved pharmaceuticals, cosmetics, and animal products.

2-G-3-O-ASA: 0.5 or 2-O-3-G-ASA: 0.5, sodium pyrrolidonecarboxylate 1.0, polyoxyethylene methylpolysiloxane copolymer 2. 0, stearyltrimethylammonium chloride 1.0, cetostearyl alcohol 3.0, polyoxyethylene hydrogenated castor oil 1.0, cationized cellulose: 1.0, isostearyl myristate: 1.0, propylene glycol: 5.0 Hydroxybenzophenone 0.1, and 100 with purified water.
This formula is an example of scalp emulsifier, systemic emulsifier, treatment agent, rinse agent, treatment, nail treatment, perm after treatment, perm pre-treatment, hair color after treatment, hair color pre-treatment.
This prescription is an example of a solution for external application for pharmaceuticals, quasi-drugs, medical cultures, medical devices, medical devices, unapproved pharmaceuticals, cosmetics, and animal products.

2-G-3-O-ASA: 0.5, or 2-O-3-G-ASA: 0.5, behenic acid 5.0, stearic acid 3.0, cetyltrimethylammonium chloride: 8.5 , Diallyl (12-18) dimethylammonium chloride 0.5, cationized keratin hydrolyzate 0.2, ceramide 30.1, amino-modified silicone emulsion: 0.2, dipentaerythritol fatty acid ester 0.3, hydroxymethoxy Benzophenonesulfonic acid 0.3, diethylene glycol monoethyl ether: 1.0, benzyloxyethanol 0.5, hydroxyethyl cellulose: 0.4, sodium citrate 2.0, and 100 with purified water. This formula is an example of scalp emulsifier, systemic emulsifier, treatment agent, rinse agent, treatment, nail treatment, perm after treatment, perm pre-treatment, hair color after treatment, hair color pre-treatment.
This prescription is an example of a solution for external application for pharmaceuticals, quasi-drugs, medical cultures, medical devices, medical devices, unapproved pharmaceuticals, cosmetics, and animal products.

2-G-3-O-ASA: 0.5, or 2-O-3-G-ASA: 0.5, sodium bicarbonate 60.0, borax 5.0, sodium hyaluronate 1.0, Hydroxypropyl methylcellulose 1.0, Karin extract 5.0, Antibacterial agent 0.7, Anhydrous sodium sulfate: The remainder was used as a bath agent.
This prescription is an example of a solution for external application for pharmaceuticals, quasi-drugs, medical cultures, medical devices, medical devices, unapproved pharmaceuticals, cosmetics, and animal products.

Catching agent 2-G-3-O-ASA: 0.1,2-O-3-G-ASA: 0.05, l-menthol 3.0, DL-camphor 1.5, polyacrylic acid: 4. 5, sodium polyacrylate 1.5, sodium carboxymethylcellulose 4.0, glycerol 20.0, sorbitol 5.0, polyoxyethylene nonylphenyl ether 0.5, kaolin: 5.0, PVP: 5.0, Castor oil: 1.0, purified water: residue The above-mentioned components dissolved, dispersed and kneaded were spread on a polyester non-woven fabric so as to be 1000 g per 1 m 2 to produce a patch.
This was used as a patch, pack, washing pack, oil pack, peel-off pack, skin patch test kit, bandage, adhesive bandage, cloth, skin ribbon, hair pack, adhesive bandage, gauze for external use.
This prescription is an example of a solution for external application for pharmaceuticals, quasi-drugs, medical cultures, medical devices, medical devices, unapproved pharmaceuticals, cosmetics, and animal products.

   2-G-3-O-ASA: 0.1, 2-O-3-G-ASA: 0.01 as well as moisturizer, anti-inflammatory agent, cell activator, antioxidant, etc. on gauze or non-woven fabric The mixed formulation solution was impregnated and attached to the wound. The above was directly sprayed locally, covered with gauze, non-woven fabric, and paper, and used as a two-pack type pack, coated preparation, and tissue paper for coating. The composition of this prescription is also an example as an external preparation for pharmaceuticals, quasi drugs, unapproved pharmaceuticals, and cosmetics.

2-G-3-O-ASA: 0.1, 2-O-3-G-ASA: 0.05, DL-α-tocopherol acetate 0.5, g silicone oil 30.0, g Tween 800. 0, 5 g Corn starch 48.9, 5 g The above ingredients were mixed uniformly, and 200 mg was filled into a gelatin capsule to produce a capsule.
This was used as an external capsule, oral capsule, or animal oral capsule. This product is fertilizer, oral composition, food, animal medicine, agriculture and forestry supplies, horticultural supplies, granules, powder, water treatment agent, pharmaceuticals, quasi-drugs, unapproved pharmaceuticals, cosmetics, oral preparations These are examples of oral preparations and external preparations.

Liquid formulation
2-G-3-O-ASA: 0.01, 2-O-3-G-ASA: 0.01, Glycerin: residue
The above-mentioned preparations are insecutive, water grease, enamel remover, eau de parfum, cleansing gel, cleansing foam, cleansing mask, skin moisture, straight perm, tic, deodorant stick, deodorant spray, nail enamel, permanent wave, foundation, hair gel, hair Spray, Hair Tonic, Hair Foam, Hair Bleach, Hair Blow, Hair Manicure, Hairist, Hair Liquid, Hair Wax, Body Skin Agent, Pomade, Mascara, Mask, Moose, Makeup Agent, Moisture Gel, Lip Gloss, Liniment, Liposomes Lotion, liposomal serum, liquid soap, makeup base, lotion, toilet soap, horny smootherー, Lipstick, Perfume, Perfume soap, Synthetic cosmetic soap, Oxidative hair dye, UV protection essence, Soap, Facial cleanser, Detergent, Washing powder, Depigmenting agent, Depigmentation / Hair removal agent, Insect repellent, Patch, Transparent soaps, ointments, white powders and dusts, eyebrows, fragrances, deodorant cosmetics, blushers, hair coats, medicated soaps, bath preparations, perfumes and additives.

This product is a chemical product, industrial product, civil engineering planting product, fertilizer, paint, cleaning material, agricultural and forestry product, horticultural material product, granule product, powder product, miscellaneous goods, clothing product, oral composition, food, culture Examples of compositions, veterinary drugs, photosensitive materials, water treatment agents, air purification agents, pharmaceuticals, quasi drugs, unapproved pharmaceuticals, cosmetics, oral preparations, oral preparations, and external preparations are also provided.

   2-G-3-O-ASA: 0.1 or 2-O-3-G-ASA: 0.1 g, 10 g of gelatin in purified water: Dissolve in the remainder and spray 1 ml per 100 g of product on the next product And dried under reduced pressure. Patches, transparent soap, white powder and dusts, eyebrows, fragrances, deodorant cosmetics, blushers, hair coats, medicated soaps, bath preparations, shower agents, perfumes, masks, socks, gloves, earplugs, hats, Caps, socks, underwear, tights, condoms, tampons, napkins, rings, bracelets, collars, ankles, sutures, skin tape, skin films, skin adhesives, skin staples, oiled paper, skin Paper, skin clips, skin films, skin paints, non-woven skins, skin strings, skin threads, skin tubes. This product is an example of miscellaneous goods and compositions for external use.

(Effect as a composition for external use)
Polyacrylic acid Na 0.5%, Carbopol 0.5%, Phenoxyethanol 0.7%, Purified water (residue) formulation for external use (hereinafter referred to as external use base or placebo) High purity 2-G-3-O-ASA or 2-O-3-G-ASA was added to 1% by mass. In addition, as a comparative product, the conventional 2-G-3-O-ASA or 2-O-3-G-ASA is added to the above-mentioned test drug base at the same concentration as the target section, and it is applied to humans. Anti-wrinkle action, anti-acne action, moisturizing action, pressure ulcer, and anti-contact dermatitis action were evaluated. A group of 10 patients suffering from erythema due to allergic contact dermatitis on wrinkles, acne, dry skin, pressure ulcers, and metals was collected and tested. That is, a test group of a preparation containing high purity 2-G-3-O-ASA or 2-O-3-G-ASA of the present invention, non-high purity 2-G-3-O-ASA or 2-O-3-G-ASA group, placebo group not containing 2-G-3-O-ASA or 2-O-3-G-ASA, ASA- as a comparative product of the conventional ascorbic acid derivative Each effect was evaluated about the group which added 1 mass% of 2-phosphate Mg (APM) and ASA-2-phosphate Na (APS). The base for external use was applied twice a day in the morning and evening so as to be about 0.01 ml / square cm. The skin of the lesioned part before the start of the application test and 60 days after the start of the application was scored for the redness of inflammation of wrinkles, acne and erythema using the facial image processing analyzer VISIA. VISIA built-in automatic calculation software was used for digitization. Drying was compared by measuring stratum corneum moisture content and epidermal moisture transpiration. For pressure ulcers, the degree of improvement was compared with the naked eye according to the pressure ulcer standard manual and quantified. Table 9 shows the results of the effects of the composition for external use.

As a result of obtaining each% after 60 days when the score of the target area is 100%, the effect of 2-G-3-O-ASA of the present invention is 125% on average when the target area is 100%. Improvement of dry skin due to improvement in skin layer, 122% increase in stratum corneum moisture, 86% decrease in epidermal moisture transpiration (14% decrease in epidermal moisture transpiration), redness score 82 as erythema index due to metal allergic contact dermatitis % (Red score decreased by 13%), acne improved by 72% (28% decreased red score), pressure ulcer improved by 82% (reduced by 18%).
Similarly, the effect of 2-O-3-G-ASA of the present invention is to improve wrinkles on average 120%, increase stratum corneum water content 127%, epidermis water transpiration 83% (epidermal water transpiration 17% decrease) ) Reduction of dry skin, reduction of erythema index 81% (red score decreased by 19%) due to metal allergic contact dermatitis, improvement of acne 78% (reduce red score of 22%), pressure ulcer 86 % (14% decrease). In addition, the preparation containing 2-G-3-O-ASA or 2-O-3-G-ASA of the present invention was excellent in all items as compared with existing APM and APS. From the above results, the high-purity 2-G-3-O-ASA and 2-O-3-G-ASA of the present invention are changed from the conventional non-high-purity 2-G-3-O-ASA and 2-O-3. When compared with -G-ASA, clear effects on anti-wrinkle, anti-acne, moisturizing, pressure ulcer, and anti-contact dermatitis were confirmed. From this result, this product is extremely effective as a pharmaceutical composition, quasi-drug, unapproved pharmaceutical product, and cosmetics as an external composition containing the high-purity Gly-Oct-ASA of the present invention as an ASA source and with suppressed generation of ASA radicals. It was confirmed that.

(Anti-pathogenic skin resident microbial action)
For the pathogenic skin resident microorganisms of Staphylococcus aureus, Malassezia, Candida, Trichophyton rubulum, and Propionibacterium acnes, high-purity 2-G-3-O-ASA and 2-O-3- The effect of G-ASA was investigated. By using the Staphylococcus aureus, Malassezia, Candida, Trichophyton rubulum, Propionibacterium acnes and paper disk method (diameter 6 mm), the high purity 2-G-3-O-ASA and 2- O-3-G-ASA was used by dissolving in dimethyl sulfoxide (DMSO) so as to be 1.0 w / v% and 0.1 w / v%. The culture was carried out under anaerobic conditions at 37 ° C. for 7 days using an egg yolk mannitol salt medium, a chrome agar medium, a potato glucose agar medium, a potato dextrose agar medium, and a GAM medium. As a result, the high-purity 2-G-3-O-ASA and 2-O-3-G-ASA of the present invention have clear inhibition circles and have antibacterial and bactericidal action at concentrations of 0.1% to 1%. Was confirmed.

[Emulsion composition having lamellar liquid crystal structure]
The total amount of one or more compounds selected from group B OH-containing compounds is 16 g, and the total amount of one or more compounds selected from group A surfactants is 3 g. Add 0.1g of 2-O-3-G-ASA and knead well with an electric hand mixer for 10 minutes. Add 5g of a total of one or more compounds selected from Group E lipids. Knead well for 10 minutes with a hand-held mixer. Further, 5 g of a total amount of one or more compounds selected from group E lipids is added and kneaded for 10 minutes with an electric hand mixer. This lipid addition operation is repeated a total of 4 times to add a total of 20 g of lipid. Purified water was added thereto to make 100 g, and the mixture was stirred for 10 minutes with an electric hand mixer so as not to generate bubbles, and completely dispersed to obtain an emulsified composition of the present invention. This emulsion composition was treated with a microfluidizer to obtain an emulsion composition having an average particle diameter of 300 nm. When this emulsion composition is observed with a polarizing microscope, an interference image (maltese cross image) peculiar to an emulsion capsule having a multilayer vesicle structure (lamellar liquid crystal structure) is obtained, and it is confirmed that this emulsion composition has a lamellar liquid crystal structure. It was. Further, it was sterilized with a membrane filter having a 45 μm hole and sealed in a sterile vial.

This composition is a chemical product, industrial product, civil engineering greening product, fertilizer, paint, cleaning material, agricultural and forestry product, horticultural material product, granule product, powder product, miscellaneous goods, clothing product, oral composition, food, Examples of culture compositions, animal drugs, photosensitive materials, water treatment agents, and air purification agents. Furthermore, it is also an example of a composition for external use of pharmaceuticals, quasi drugs, unapproved pharmaceuticals, and cosmetics.
Compared to 2-G-3-O-ASA or 2-O-3-G-ASA single formulation, this formulation reduces the occurrence of coloring, precipitation and off-flavor and improves the stability of the formulation. Compared to Gly-Oct-ASA, the stable period was extended by about 140%. If the stable period of the drug product was extended, the distribution organization became longer, leading to a significant cost reduction. When making a lamellar liquid crystal emulsion of 2-G-3-O-ASA or 2-O-3-G-ASA of the present invention, 2-G-3-O-ASA or 2-O-3 -G-ASA absorbency is increased by 220% compared with non-lamellar liquid crystal emulsion composition, whitening action, free radical inhibiting action, anti-wrinkle action, anti-acne action, moisturizing action, barrier function enhancing action, ultraviolet ray The anti-inflammatory effect and the anti-decubitus effect were increased by about 123% on average, and the effects were so great that they could not be expected. By the way, preparations using this lamellar liquid crystal need only have an effective concentration of 2-G-3-O-ASA or 2-O-3-G-ASA of 0.001% or more in the preparation. It is effective at. This is thought to be due to an increase in skin absorption rate.

 Further, even when the concentration of 2-G-3-O-ASA or 2-O-3-G-ASA in the preparation was 1%, no skin irritation was exhibited. This was thought to be because the skin irritation of 2-G-3-O-ASA or 2-O-3-G-ASA was weakened by lamellar liquid crystals. From this result, this product is extremely effective as a pharmaceutical composition, quasi-drug, unapproved pharmaceutical product, and cosmetics as an external composition containing the high-purity Gly-Oct-ASA of the present invention as an ASA source and with suppressed generation of ASA radicals. It was confirmed that. 2-G-3-O-ASA: 0.5, (2) Glycerin 6.5, (3) 1,3-butylene glycol 1.0, (4) Phenoxyethanol 0.5, (5) Fragrance complex 0.1 (6) Essential oil complex 0.1, (6) Purified water: remaining amount (7) Citric acid 1.0 (8) The pH was adjusted to 7 with NaOH.

 Furthermore, this composition is a chemical product, industrial product, civil engineering greening product, fertilizer, paint, cleaning material, agricultural and forestry product, horticultural material product, granule product, powder product, miscellaneous goods, clothing product, oral composition, food product. As an antioxidant for culture compositions, animal drugs, photosensitive materials, water treatment agents, and air purification agents, it is also more effective than conventional ASA, ASA phosphoric acid Mg, and conventional non-pure Gly-Oct-ASA Met.

Group A (surfactant) 8279
Cocoyl glutamate Na, cocoyl glutamate K, cocoyl glutamate Na, cocoyl glutamate TEA, cocoyl glutamate TEA, lauroyl aspartate Na, lauroyl glutamate Na, myristoyl glutamate Na, palm fatty acid glutamate Na, ASA-2-phosphate-6-palmitate 3Na, dl-α-tocopheryl sodium phosphate, (ascorbyl / tocopheryl) phosphate K, isostearyl ascorbyl phosphate 2Na, ascorbyl 6-stearate, ascorbyl 6-palmitate, ascorbyl 2,6-dipalmitate
Group B (OH-containing compound) 7583
Glycerin, diglycerin, triglycerin, polyglycerin, 3-methyl-1,3-butanediol, 1,3-butylene glycol, isoprene glycol, polyethylene glycol, 1,2-pentanediol, 1,2-hexanediol, propylene Glycol, dipropylene glycol, polypropylene glycol, ethylene glycol, diethylene glycol, neopentyl glycol, polyethylene glycol, sorbitol, xylitol, pyrrolidone carboxyl sodium, hyaluronic acid, carrageenan, alginic acid, agar, fucoidan, pectin, locust bean gum, xanthan gum, tragacanth gum, Guar gum, carboxymethylcellulose, hydroxyethylcellulose, polyvinyl alcohol, polyvinylpyrrolidone, carbo Xyvinyl polymer, acrylic acid / methacrylic acid copolymer, polyglutamic acid group E9497
Mineral oil, liquid paraffin, squalane, squalene, isopropyl palmitate, isopropyl myristate, isooctyl myristate, isotridecyl myristate, octadecyl myristate, octyldodecyl myristate, isostearyl cholesteryl ester, 2-ethylhexanoic acid triglyceride, 2-ethyl Cetyl hexanoate, sunflower oil, olive oil, jojoba oil, camellia oil, grape seed oil, avocado oil, macadamia nut oil, almond oil, rice germ oil, clove oil, orange oil, spruce oil, stearic acid and palmitic acid

[Emulsion composition having lamellar liquid crystal structure]
15 g of glycerin and diglycerin, triglycerin, polyglycerin, 3-methyl-1,3-butanediol, 1,3-butylene glycol, isoprene glycol, polyethylene glycol, 1,2-pentanediol, 1,2-hexanediol , Propylene glycol, dipropylene glycol, polypropylene glycol, ethylene glycol, diethylene glycol, neopentyl glycol, polyethylene glycol, sorbitol, xylitol, sodium pyrrolidone carboxylate, hyaluronic acid, carrageenan, alginic acid, agar, fucoidan, pectin, locust bean gum, xanthan gum, Tragacanth gum, guar gum, carboxymethylcellulose, hydroxyethylcellulose, polyvinyl alcohol, polyvinylpyrrolidone A total of 3.6 g each of carboxyvinyl polymer, acrylic acid / methacrylic acid copolymer and polyglutamic acid, and cocoyl glutamate Na, cocoyl glutamate K, cocoyl glutamate Na, cocoyl glutamate TEA, cocoyl glutamate TEA, lauroyl aspartate Na, Lauroyl Glutamate Na, Myristoyl Glutamate Na, Palm Fatty Acid Na Glutamate, ASA-2-Phosphate-6-Palmitate 3Na, dl-α-Tocopheryl Sodium Phosphate, (Ascorbyl / Tocopheryl) Phosphate K, Isostearyl Ascorbyl Rin Acid 2Na, Ascorbyl 6-stearate. Ascorbyl 6-palmitate, Ascorbyl 2,6-dipalmitate to 0.1 g each, 0.05 g 2-G-3-O-ASA and 2-O-3-G- Add 0.05g of ASA and knead well with an electric hand mixer for 10 minutes Mineral oil, liquid paraffin, squalane, squalene, isopropyl palmitate, isopropyl myristate, isooctyl myristate, isotridecyl myristate, octadecyl myristate, octyldodecyl myristate, isostearyl cholesteryl ester, 2-ethylhexanoic acid triglyceride, 2-ethyl Cetyl hexanoate, sunflower oil, olive oil, jojoba oil, camellia oil, grape seed oil, avocado oil, macadamia nut oil, almond oil, rice germ oil, clove oil, orange oil, spruce oil, stearic acid, palmitic acid each 0. Take 2g each to make a total of 5.4g, add this and knead well with an electric hand mixer for 10 minutes. This lipid addition operation is repeated a total of 4 times to add a total of 21.6 g of lipid. This was added to make 100 g, and stirred for 10 minutes with an electric hand mixer so as not to generate bubbles, and completely dispersed to obtain an emulsified composition of the present invention.
This composition is an example of an oral composition, a food, a culture composition, a water treatment agent for animal drug drinks, and an air purification agent. It is also an example of oral compositions for pharmaceuticals, quasi drugs, and unapproved pharmaceuticals.

This emulsified composition was treated with a microfluidizer to obtain an emulsified composition having an average particle diameter of 500 nm. When this emulsified composition was observed with a polarizing microscope, an interference image peculiar to the lamellar liquid crystal structure was obtained, and it was confirmed that the emulsified composition had a lamellar liquid crystal structure. Further, it was sterilized with a membrane filter having a 45 μm hole and sealed in a sterile vial. Compared to 2-G-3-O-ASA or 2-O-3-G-ASA single formulation, this formulation reduces the occurrence of coloring, precipitation and off-flavor and improves the stability of the formulation. Compared to -G-3-O-ASA or 2-O-3-G-ASA alone, the stability period was extended by about 155%. If the stable period of the drug product was extended, the distribution organization became longer, leading to a significant cost reduction. When making a lamellar liquid crystal emulsion of 2-G-3-O-ASA or 2-O-3-G-ASA of the present invention, 2-G-3-O-ASA or 2-O-3 -The absorption of G-ASA from the intestinal tract increased by 147%, and the antioxidant power in blood increased by about 129% on average. Even compared with the effect of the conventional polyphenol, the value was about 10% higher.
From this result, it is confirmed that this product is extremely effective as an oral composition, food, culture composition, animal medicine, drinking water treatment agent, air purifier, pharmaceutical, quasi-drug, unapproved pharmaceutical, and cosmetic. It was done.
Furthermore, this composition is a chemical product, industrial product, civil engineering greening product, fertilizer, paint, cleaning material, agricultural and forestry product, horticultural material product, granule product, powder product, miscellaneous goods, clothing product, photosensitive material, water treatment agent. As an antioxidant for air purification agents, it was also effective compared to conventional ASA, ASA phosphoric acid Mg, and conventional non-pure Gly-Oct-ASA.

[Emulsion composition having lamellar liquid crystal structure]
6g glycerin and sodium cocoyl glutamate, cocoyl glutamate K, cocoyl glutamate Na, cocoyl glutamate TEA, cocoyl glutamate TEA, lauroyl aspartate Na, lauroyl glutamate Na, myristoyl glutamate Na, palm fatty acid glutamate Na, ASA-2-phosphate-6- Palmitate 3Na, dl-α-tocopheryl sodium phosphate, (ascorbyl / tocopheryl) phosphate K, isostearyl ascorbyl phosphate 2Na, 6-ascorbyl stearate, 6-ascorbyl palmitate, 2,6-dipalmitate ascorbyl Add 0.05 g of 2-G-3-O-ASA and 0.05 g of 2-O-3-G-ASA to 0.1 g each and knead well with an electric hand mixer for 10 minutes. Add 5.4 g of jojoba oil. Knead well with an electric hand mixer for 10 minutes. This operation of adding jojoba oil is repeated a total of 4 times to add a total of 21.6 g of lipid. Purified water was added thereto to make 100 g, and the mixture was stirred for 10 minutes with an electric hand mixer so as not to generate bubbles, and completely dispersed to obtain an emulsified composition of the present invention. This emulsified composition was treated with a microfluidizer to obtain an emulsified composition having an average particle diameter of 500 nm. Further, it was sterilized with a membrane filter having a 45 μm hole and sealed in a sterile vial. When this emulsified composition was observed with a polarizing microscope, an interference image peculiar to the lamellar liquid crystal structure was obtained, and it was confirmed that the emulsified composition had a lamellar liquid crystal structure.
This composition is a chemical product, industrial product, civil engineering greening product, fertilizer, paint, cleaning material, agricultural and forestry product, horticultural material product, granule product, powder product, miscellaneous goods, clothing product, oral composition, food, Examples of culture compositions, animal drugs, photosensitive materials, water treatment agents, and air purification agents. Furthermore, it is also an example of a composition for external use of pharmaceuticals, quasi drugs and unapproved pharmaceuticals.

 In tissue absorption tests using a three-dimensional human skin culture model using this preparation, the retention concentration test of 2-G-3-O-ASA or 2-O-3-G-ASA in the skin and the marker From the results of the retention test of blue fluorescent protein in the dermis, the maximum concentration is 3.3 times higher than that of normal emulsified capsules that do not have a lamellar liquid crystal structure of the same formulation, and 2-G-3-O-ASA. In addition, the residence time of 2-O-3-G-ASA and fluorescent protein is 2.6 times longer, and the 2-G-3-O-ASA or 2-O-3-G-ASA of the present invention is used. It was confirmed that the permeability of the contained multilayer emulsion capsule was increased. In addition, this product is more stable than the single formulation of 2-G-3-O-ASA or 2-O-3-G-ASA. The stabilization period was extended by about 148%. If the stable period of the drug product was extended, the distribution organization became longer, leading to a significant cost reduction. When making a lamellar liquid crystal emulsion of 2-G-3-O-ASA or 2-O-3-G-ASA of the present invention, 2-G-3-O-ASA or 2-O-3 -Absorbability of G-ASA increased by 159%. Compared to the effects of conventional polyphenols, these were unexpectedly large effects.

 This composition is a chemical product, industrial product, civil engineering greening product, fertilizer, paint, cleaning material, agricultural and forestry product, horticultural material product, granule product, powder product, miscellaneous goods, clothing product, oral composition, food, Examples of culture compositions, animal drugs, photosensitive materials, water treatment agents, and air purification agents. Furthermore, it is also an example of a composition for external use of pharmaceuticals, quasi drugs, and unapproved pharmaceuticals.

   The lamellar liquid crystal emulsion of Example 13: 30% by mass, the lamellar liquid crystal emulsion of Example 14: 30% by mass, and the lamellar liquid crystal emulsion of Example 15: 30% by mass were mixed to 100% by mass of the present invention. G-3-O-ASA or 2-O-3-G-ASA containing lamellar liquid crystal emulsified external composition and active ingredient 2-G-3-O-ASA or 2-O-3- Using the same emulsified preparation without G-ASA as a negative control, it has anti-wrinkle action, anti-acne action, moisturizing action, barrier function enhancing action, UV-induced inflammation suppressing action, anti-decubitus action and free radical suppressing action on humans. evaluated. Each of 20 healthy subjects and 20 patients each suffering from wrinkles, acne, dry skin, ultraviolet ray-derived inflammation, and pressure ulcers was evaluated. In the case of healthy individuals, 0.01 ml of the above-mentioned external preparation is applied twice a day in the morning and evening for the cheeks and other patients, and the color of the lesioned part before the start of the application test and 10 days after the start of the application Images were taken with a digital camera under lighting conditions, and wrinkles, acne, and UV-induced inflammation (erythema) were quantified using the image processing device VISIA. For healthy individuals, the amount of lipid peroxide in the sebum was measured by immersing the amount of skin lipid peroxide in the filter paper. Drying and barrier function were compared by measuring stratum corneum moisture content and epidermal moisture transpiration. For pressure ulcers, the degree of improvement was compared with the naked eye according to the pressure ulcer standard manual and digitized. Assuming that the negative control without 2-G-3-O-ASA or 2-O-3-G-ASA was taken as 100%, the percentages after 10 days were determined. The effect of 2-G-3-O-ASA or 2-O-3-G-ASA of Example 1 (% difference from control) is an improvement of 66% on average in comparison with placebo, stratum corneum 141% increase in moisture content, improvement of dry skin by improving 132% epidermal moisture transpiration, 25% decrease in erythema derived from ultraviolet rays, 55% decrease in acne, 41% decrease in pressure sores, anti-wrinkle activity, anti-acne activity, The effects of 2-G-3-O-ASA or 2-O-3-G-ASA on moisturizing action, barrier function enhancing action, ultraviolet ray-derived inflammation inhibiting action and anti-decubitus action were confirmed.

 Furthermore, the lipid peroxide concentration of sebum collected from the cheek skin of a healthy person decreased by 36% compared to the negative control, confirming the action of suppressing free radicals on the skin. Compared to the effects of conventional polyphenols, these were unexpectedly large effects. From this result, this product is extremely effective as a pharmaceutical composition, quasi-drug, unapproved pharmaceutical product, and cosmetics as an external composition containing the high-purity Gly-Oct-ASA of the present invention as an ASA source and with suppressed generation of ASA radicals. It was confirmed that.

 Furthermore, this composition is a chemical product, industrial product, civil engineering greening product, fertilizer, paint, cleaning material, agricultural and forestry product, horticultural material product, granule product, powder product, miscellaneous goods, clothing product, oral composition, food product. As an antioxidant for culture compositions, animal drugs, photosensitive materials, water treatment agents, and air purification agents, it is also more effective than conventional ASA, ASA phosphoric acid Mg, and conventional non-pure Gly-Oct-ASA Met.

Oral composition
92.7% animal fat and oil of melting point 28 ± 3 ° C consisting of 50% chicken oil and 50% pork oil, 0.9% enzyme, 1% 2-G-3-O-ASA, 2- Vitamin premix 1.0% added with 1% O-3-G-ASA, 0.9% powdered fungicide, 4.5% fragrance for 2 hours in a 200L stirring mixer manufactured by Meiji Kikai Co., Ltd. The oral composition of the present invention in which the vitamin C source of the present invention consisting of powder particles having an average particle size of 0.51 mm in the particle size distribution was stirred and dispersed was obtained. The oral composition of the present invention is an example of feed, feed additive, food, food additive, functional food, or oral animal medicine.

 This preparation was blended in the following oral composition composition at a blending ratio of 1% by mass to produce an antioxidant-enhanced oral composition for each animal with an enhanced vitamin C source. The target animals for the combined oral composition are cattle, pigs, horses, sheep and other livestock, poultry, aquaculture animals and other domestic animals, dogs, cats, pets, rats, mice, guinea pigs, monkeys, etc. Laboratory animals, meat chickens (broilers), egg-laying chickens, quails, ducks, ducks, pheasants, turkeys, etc. , Sweetfish, shrimp (shrimp, button shrimp, lobster, crayfish, black tiger), crabs (crab crab, snow crab, crabs, crabs), shellfish (pearl shells, abalone, scallops, clams, oysters) They were squid, octopus, sea urchin, beetle, stag beetle and silkworm. The oral composition of the present invention is an example of feed, feed additive, food, food additive, functional food, or oral animal medicine.

From 1% by weight of mineral mix with 25% by weight of soybean powder, 65% by weight of corn powder, 8% by weight of fish powder, 1% of 2-G-3-O-ASA and 1% of 2-O-3-G-ASA The oral composition raw material used is a DFEA-220 type expander manufactured by Buehler Co., Ltd. Operating conditions maximum temperature 120 ° C., heating average time 150 seconds, barrel pressure 20 atm, inlet raw material moisture content 11.5% by mass, outlet moisture content 18 .Semi-finished product by gas pumping at a nozzle diameter of 3mm x 10mm and a pressure of 2atm from a circulating flow pipeline to a semi-finished product heated at a rate of 5 mass% and outlet product temperature of 100 ° C at a rate of 8500kg / hour Then, it was blown and dried at room temperature for 30 minutes with a DFKC-2 / 6 type dryer manufactured by Buehler, so as to be 1% by mass, and then naturally cooled to obtain an oral composition product. The target animals for which this oral composition can be used are the following mammals. They were mammal livestock such as cattle, pigs, horses and sheep, mammal pets such as dogs and cats, and laboratory animals such as rats, mice, guinea pigs and monkeys. The oral composition of the present invention is an example of feed, feed additive, food, food additive, functional food, or oral animal medicine.

   Corn 56.3 mass%, Milo 9.0 mass%, bran 5.0 mass%, defatted rice bran 2.3 mass%, soybean meal 7.0 mass%, fish cake 7.0 mass%, alfalfa meal 2.0 mass% %, Calcium carbonate 7.1% by mass, tricalcium phosphate 1.2% by mass, salt 0.2% by mass, 2-G-3-O-ASA 1%, 2-O-3-G-ASA 1 The maximum operating temperature is 118 ° C. using a DFEA-220 type expander manufactured by Buehler as a raw material consisting of 0.1% by weight of vitamin / mineral mix added, 1.0% by weight of tallow oil and fat, and 1.8% by weight of corn glute. Heated average time 150 seconds, barrel pressure 20 atm, inlet raw material moisture content 13.0% by weight, outlet moisture content 18.8%, outlet product temperature 96 ° C., semi-finished product is quantitatively conveyed at 8000 kg / hour. Where the circulating fluid pipeline is After spraying the semi-finished product to 2.11% by mass by gas pumping with a nozzle diameter of 3 mm × 10 mm and a pressure of 2 atm, it was blown and dried at room temperature for 30 minutes with a DFKC-2 / 6 dryer manufactured by Buehler. Then, it was naturally cooled to obtain an oral composition. The animals that can use this composition for oral use are mainly birds, such as poultry such as meat chickens (broilers), egg-laying chickens, quails, ducks, ostriches, ducks, pheasants, turkeys, birds, canaries, parrots, penguins, swans, etc. Ornamental birds. The oral composition of the present invention is an example of feed, feed additive, food, food additive, functional food, or oral animal medicine.

Soybean flour 3%, Gluten meal 5%, Fish flour 70%, Wheat flour 10%, Non-fat rice bran 10%, 2-G-3-O-ASA 1%, 2-O-3-G-ASA Using a DFEA-220 type expander (Extruder) manufactured by Buehler, a raw material consisting of 0.5% by mass of a mineral mix with 1% of the operating conditions, operating temperature maximum temperature 110 ° C., heating average time 145 seconds, barrel pressure 13 atm. A semi-finished product heated at an inlet raw material moisture content of 10.5%, an outlet moisture content of 17.2%, and an outlet product temperature of 93 ° C. is conveyed at a constant rate of 8100 kg / hr. Sprayed to 10% by gas pressure of 2 atm to 1.5% by mass of this semi-finished product, blown and dried at room temperature for 30 minutes with a DFKC-2 / 6 dryer manufactured by Buehler, then naturally cooled and used for oral use Composition It was. This composition for oral use was mainly used for marine animals such as fish, shellfish, shrimp and crab.
The oral composition of the present invention is an example of feed, feed additive, food, food additive, functional food, or oral animal medicine.

(Efficacy test of oral composition)
The effect of the composition for oral administration to which the ASA derivative of the present invention was added was confirmed by experiments using mice. In order to confirm the inhibitory effect of plasma LDH, MDH, AspAT and blood stress protein, the following experiment was conducted to confirm the effect of the present invention.
In test plot 1 of the present invention, 0.02 mmol of high purity 2-G-3-O-ASA and 0.02 mmol of 2-G-3-O-ASA of the present invention are added to ASA per kg of body weight per day. Added to the oral composition without added source and fed naturally. In Comparative Group 1, an oral composition containing 0.02 mmol of conventional 2-G-3-O-ASA and 0.02 mmol of 2-G-3-O-ASA as a comparative product was added. Was naturally fed with an oral composition supplemented with 0.04 mmol of ASA-6-palmitate. Moreover, the oral composition which added 0.04 millimole of ASA as a target section was naturally fed.

On the test start day, as a stressor, the test was exposed to an environment of 40 ° C. for 30 minutes, and thereafter, the room temperature was lowered to 25 ° C. and stress for 30 minutes passed was applied 8 times a day. Breeding with the oral composition of the test group and the control group for 20 days from the start date of the test, respectively, blood was collected from each mouse 61 days later, plasma LDH, MDH, AspAT and blood stress protein in the blood, weight gain Was measured.
For the stress protein measurement, the analysis of stress protein in plasma was performed using SDS electrophoresis, and the relative ratio was determined from the absorbance using a gel scanner.

(Weight gain ratio) The body weight at the start of the test was measured in each of the target group, the comparison group, and the test group, and the value obtained by the following calculation formula was compared as a weight gain score after the test was completed. This means that the smaller the weight ratio score, the greater the weight.
Weight gain ratio score = (weight at the end of the study in the subject group-weight at the start of the study in the subject group) / (weight at the end of the study in the study group or the comparison group-body weight at the start of the test in the test group or the comparison group) × 100
The average score of LDH, MDH, AapAT, and stress protein in the blood of mice and the ratio score of the values of the respective target sections corresponding thereto were calculated by the following formula, and the results expressed as percentages are shown in Table 10. This means that the smaller the ratio score, the better. Table 10 shows the effect of the orally administered composition on plasma LDH, MDH, AspAT and blood stress protein.
Ratio score = (value of test zone or comparison zone) / (value of target zone) × 100

The average values of LDH, MDH, AspAT, and stress ptothein in blood after stress of mice of the oral composition to which the ASA derivative of the present invention was added significantly decreased compared with that of the control group, and the improvement order was Test group 1 of the present invention was the best, followed by comparative product 1 and comparative product 2 of the conventional product.
Similarly, the improvement in weight gain was also the highest in the test group 1, followed by the conventional comparison group 1 and the comparison group 2. The composition for oral administration containing the high-purity ASA derivative of the present invention showed a better effect than the composition containing no ASA. 2-octyl-3-O-glyceryl ASA: 0.5, (2) glycerin 6.5, (3) 1,3 butylene glycol 1.0, (4) phenoxyethanol 0.5, (5) perfume complex 0.5. 1, (6) Essential oil complex 0.1, (6) Purified water: Remaining amount (7) Citric acid 1.0 (8) The pH was adjusted to 7 with NaOH.
These results are examples showing the effects of oral compositions, foods, health foods, functional foods, nutritional compositions, and veterinary drugs. Furthermore, it is an example of the effect of oral administration of pharmaceuticals, quasi drugs, and unapproved pharmaceuticals.

(Biodegradable yarn)
2.5 g of high purity 2-O-3-G-ASA and 2.5 g of 2-G-3-O-ASA of the present invention were dissolved in 50 ml of purified water. 1.0 g of the product name “Dexon” manufactured by Davis & Greck, which is a yarn made of PGA polymer, was immersed in this solution and then taken out. After air drying, a yarn containing the high purity 2-O-3-G-ASA and 2-G-3-O-ASA of the present invention was obtained. The yarn weight increase was 4 mg. In addition to sutures for medical supplies and quasi-drugs, this thread can be used for biodegradable fishing lines that are environmentally friendly, disposable nets for aquaculture, biodegradable foods that bind ham, meat, etc. Threads (which are broken down in the digestive tract even if eaten), agricultural materials, work clothes, socks, disposable clothing such as underwear, etc. It could also be used as yarns for industrial materials such as building materials, containers and bags knitted with yarn, shoes, hats, umbrellas, strings and ropes for waste. The biodegradable product of the present invention is a chemical product, industrial product, civil engineering greening product, fertilizer, paint, cleaning material, agricultural and forestry product, horticultural material product, granule product, powder product, miscellaneous goods, clothing product, feed, Examples of foods, culture compositions, veterinary drugs, photosensitive materials, water treatment agents, and air purification agents. It is also an example of pharmaceuticals, quasi drugs, and unapproved pharmaceuticals.

   2.5 g of high purity 2-O-3-G-ASA of the present invention and 2.5 g of 2-G-3-O-ASA were dissolved in 50 ml of purified water. 1.0 g of a trade name “PDS” manufactured by Ethicon, which is a suture made of a polydioxanone polymer, was immersed in this solution and then taken out. After air drying, a suture containing high purity 2-O-3-G-ASA and 2-G-3-O-ASA of the present invention was obtained. The yarn weight increase was 4 mg. In addition to sutures for medical supplies and quasi-drugs, this thread can be used for biodegradable fishing lines that are environmentally friendly, disposable nets for aquaculture, biodegradable foods that bind ham, meat, etc. Threads (disintegrated in the digestive tract even if eaten), agricultural materials, work clothes, socks, disposable clothing such as underwear, general household sewing, decoration and stationery, etc. It could also be used as yarns for industrial materials such as building materials, containers and bags knitted with yarn, shoes, hats, umbrellas, strings and ropes for waste. It could also be used as a thread for industrial materials such as strings and ropes for waste. The biodegradable product of the present invention is a chemical product, industrial product, civil engineering greening product, fertilizer, paint, cleaning material, agricultural and forestry product, horticultural material product, granule product, powder product, miscellaneous goods, clothing product, feed, Examples of foods, culture compositions, veterinary drugs, photosensitive materials, water treatment agents, and air purification agents. It is also an example of pharmaceuticals, quasi drugs, and unapproved pharmaceuticals.

   A gauze was woven by a conventional method using the biodegradable yarn of Example 56 as a raw material. This gauze was sterilized with ethylene oxide gas by a conventional method to obtain a gauze containing the high purity 2-O-3-G-ASA and 2-G-3-O-ASA of the present invention. In addition to gauze for medical supplies and quasi-drugs, this gauze is a biodegradable gauze that is friendly to the environment, such as a disposable net for aquaculture, biodegradable food gauze covering ham, meat, etc. , Agricultural materials, disposable clothing such as work gloves, socks and underwear, gauze for miscellaneous goods used for sewing, decoration, and stationery for general households, building materials for the purpose of temporary binding, containers made of gauze It can also be used as a gauze for industrial materials such as bags, shoes, hats, umbrellas, and cloth for waste. It could also be used as a thread for industrial materials such as strings and ropes for waste. The biodegradable product of the present invention is a chemical product, industrial product, civil engineering greening product, fertilizer, paint, cleaning material, agricultural and forestry product, horticultural material product, granule product, powder product, miscellaneous goods, clothing product, feed, Examples of foods, culture compositions, veterinary drugs, photosensitive materials, water treatment agents, and air purification agents. It is also an example of pharmaceuticals, quasi drugs, and unapproved pharmaceuticals.

A nonwoven fabric was prepared from the yarn of Example 56 as a raw material by a conventional method to prepare a gauze. This gauze is sterilized with ethylene oxide gas by a conventional method, and contains a high-purity 2-O-3-G-ASA and 2-G-3-O-ASA polymer composition for wound healing for living tissues. It was set as the nonwoven fabric gauze which is an Example of a thing. Furthermore, 10 g of fibroblast growth factor (FGF), 10 mg of glycyrrhizic acid, 1 mg of benzalkonium chloride, and 10 mg of dl-α-tocopheryl phosphate Na were separately prepared separately in 1 g of this structure. In addition to gauze for medical supplies and quasi-drugs, this gauze is a biodegradable gauze that is friendly to the environment. , Agricultural materials, disposable clothing such as work gloves, socks and underwear, gauze for miscellaneous goods used for sewing, decoration, and stationery for general households, building materials for the purpose of temporary binding, containers made of gauze It can also be used as a gauze for industrial materials such as bags, shoes, hats, umbrellas, and cloth for waste.
It could also be used as a thread for industrial materials such as strings and ropes for waste.
The biodegradable product of the present invention is a chemical product, industrial product, civil engineering greening product, fertilizer, paint, cleaning material, agricultural and forestry product, horticultural material product, granule product, powder product, miscellaneous goods, clothing product, feed, Examples of foods, culture compositions, veterinary drugs, photosensitive materials, water treatment agents, and air purification agents. It is also an example of pharmaceuticals, quasi drugs, and unapproved pharmaceuticals.

  Further, the gauze was cut into an appropriate length and sterilized in the same manner to prepare a bandage, a poultice, and a bandage. An adhesive bandage was prepared by combining this cloth 1 cm × 1 cm with an adhesive tape 1 cm wide and 3 cm long. The adhesive bandage and the poultice were given adhesive properties by spray drying a 10% solution of purified gelatin manufactured by Nippi Collagen on the adhesive side. These are sterilized with ethylene oxide gas by a conventional method, and bandages, adhesive plasters, and comparative examples of bandages, adhesive plasters, poultices, which are examples of the ASA derivative-containing biological tissue wound healing polymer composition of the present invention, and did. It could also be used as a thread for industrial materials such as strings and ropes for waste.

 The biodegradable product of the present invention is a chemical product, industrial product, civil engineering greening product, fertilizer, paint, cleaning material, agricultural and forestry product, horticultural material product, granule product, powder product, miscellaneous goods, clothing product, feed, Examples of foods, culture compositions, veterinary drugs, photosensitive materials, water treatment agents, and air purification agents. It is also an example of pharmaceuticals, quasi drugs, and unapproved pharmaceuticals.

(Performance evaluation of biodegradable yarn)
The performance of the yarn of the present invention of Example 56 (Test Example 1) was evaluated by the following method. The back of a 10 week old guinea pig was shaved and a 2 cm long cut was made with a scalpel in a direction perpendicular to the midline of the back. Comparative yarns of Comparative Example 1 containing conventional 2-O-3-G-ASA and 2-G-3-O-ASA, comparative products made by the same manufacturing method as the yarn of Example 56 of the present invention, conventional high Only the yarn of Comparative Example 2 containing the ASA derivative, ASA-2-Na phosphate, in the same molar amount, and the high purity 2-O-3-G-ASA and 2-G-3-O-ASA of the present invention. Using the placebo yarn of Comparative Example 3 that did not contain, the wound was repaired by stitching the cut portion at five points at equal intervals. One week after this treatment, the guinea pig was subjected to ether anesthesia, a 1 cm wide strip-like skin tissue was excised from the center of the incision, and the tensile strength (g / cm) of the incision was measured using a rheometer. Ten guinea pigs were used for each example and comparative example, and the tensile strength (g / cm) was an average of the values obtained for these guinea pigs. Table 11 shows the result of the effect of increasing the tensile strength of the yarn.

From Table 11, the group using the suture containing the ASA derivative of the present invention showed a significant increase in the tensile strength compared to the group using the conventional ASA derivative containing the ASA derivative and the placebo suture. I understand. Furthermore, the erythema, inflammatory reaction, and tissue abnormalities around the suture using the suture of the present invention are clearly suppressed compared to the comparative example, and in the vicinity of the comparative example and the placebo suture, the tissue swell phenomenon, Increased area of erythema, long duration, and inflammatory condition were observed for a long time. From this, it was confirmed that the generation of active oxygen and the infiltration state of neutrophils were clearly increased in the comparative example as compared with Test Example 1. Further, although no numerical value is described in the above results, there is also a product in which fibroblast growth factor (FGF), EGF, glycyrrhizic acid 2K, benzalkonium chloride, and dl-α-tocopheryl phosphate Na are uniformly dispersed. The result was good.

(Yarn performance evaluation)
About the thread | yarn of this invention of the said Example 56, intensity | strength evaluation was carried out as an industrial material with the following method. A yarn of Comparative Example 1 containing conventional non-pure 2-O-3-G-ASA and 2-G-3-O-ASA prepared by the same production method as the yarn of Example 56 of the present invention, the conventional high Only the yarn of Comparative Example 2 containing the ASA derivative, ASA-2-Na phosphate, in the same molar amount, and the high purity 2-O-3-G-ASA and 2-G-3-O-ASA of the present invention. Using a placebo thread that does not contain, stretch for 10cm length, 7 days under the environment of 6 hours from 9am to 3pm in the environment of temperature 25 ℃ and humidity 50% I left it alone. Measure the yarn's tensile strength (g / cm) using a rheometer, take the average value of the yarn, calculate the ratio of the placebo yarn's tensile strength, and show the effect on the tensile strength. This is shown in FIG.

From Table 12, it can be seen that in the group using the yarn containing the ASA derivative of the present invention, the tensile strength was greatly increased as compared to the group using the conventional ASA derivative and the yarn of the comparative example and the yarn of the placebo. . This is thought to be because the ASA derivative of the present invention containing the active oxygen generated by ultraviolet rays in sunlight suppressed the breaking of molecular bonds in the yarn. It was considered that the normal ASA derivative was prooxidantized and the tensile strength was reduced as compared with the ASA derivative of the present invention. Since the yarn is thin, it is easily damaged by ultraviolet rays. However, in the case of the cloth and synthetic resin of the present invention made of this yarn component, the strength decrease due to the influence of active oxygen due to ultraviolet rays etc. is much suppressed. Conceivable. The biodegradable product of the present invention is a chemical product, industrial product, civil engineering greening product, fertilizer, paint, cleaning material, agricultural and forestry product, horticultural material product, granule product, powder product, miscellaneous goods, clothing product, feed, Examples of foods, culture compositions, veterinary drugs, photosensitive materials, water treatment agents, and air purification agents. It is also an example of pharmaceuticals, quasi drugs, and unapproved pharmaceuticals.

Effect of resin chip
Polybutylene succinate PBS (Bionore 1001, manufactured by Showa Polymer) 84% by mass, polyethylene terephthalate PET (Dianite PA-500, manufactured by Mitsubishi Rayon) 10% by mass, and ethylene glycidyl methacrylate copolymer E-GMA (reactive phase) (Solubilizer, BondFirst E, manufactured by Sumitomo Chemical Co., Ltd.) (Test section 1), one containing the same amount of non-high purity 2-O-3-G-ASA and 2-G-3-O-ASA (Comparative Example 1), ASA-2 which is a conventional high ASA derivative -A sodium phosphate containing the same molar amount (Comparative Example 2) and a placebo containing only the high purity 2-O-3-G-ASA and 2-G-3-O-ASA of the present invention ( Comparative Example 3) was added separately, and was prepared at 240 ° C. using a twin-screw extruder (manufactured by Technobell, KZW15-30MG). Was melt-kneaded at law, extrusion-solidified in water at a diameter of about 3mm, then cut to 3mm length, to obtain a resin chip. Furthermore, when melted separately, microbubbles made of nitrogen were blown into the paste to create a hollow structure.

   The obtained chip was press-molded to produce a femur reinforcing material and a fracture repair screw as examples of the composition containing the ASA derivative of the present invention. Furthermore, in addition to resin chips for molded products such as medical supplies and quasi drugs, this resin chip can be pressed into various molded products as environmentally friendly biodegradable resin chips, such as food containers, bags, It could also be used as a resin chip for daily miscellaneous goods, furniture, building materials, paint additives, film additives, vehicle frames, health food tablets, agricultural materials, clothing press products. The biodegradable product of the present invention is a chemical product, industrial product, civil engineering greening product, fertilizer, paint, cleaning material, agricultural and forestry product, horticultural material product, granule product, powder product, miscellaneous goods, clothing product, feed, Examples of foods, culture compositions, veterinary drugs, photosensitive materials, water treatment agents, and air purification agents. It is also an example of pharmaceuticals, quasi drugs, and unapproved pharmaceuticals.

(Effect of porous spherical aggregate particles)
Hydroxyapatite (HA) prepared to a particle size of about 50 μm by spray drying was mixed with 1 wt% sodium alginate aqueous solution so as to be 10 wt% to obtain a uniform slurry. This slurry was formed into a spherical shape by dropping 3 μl each into a 1 wt% calcium chloride aqueous solution. The spherical HA molded as described above was dried at 60 ° C. for 12 hours and then sintered at 1250 ° C. for 1 hour to obtain porous spherical aggregate particles having a diameter of 0.8 ± 0.2. The porous spherical aggregate particles are vacuum depressurized, and 2.5% by mass of high purity 2-O-3-G-ASA and 2-G-3-O-ASA of the present invention are added to ultrapure water, respectively ( Test section 1), containing the same amount of 2-O-3-G-ASA and 2-G-3-O-ASA which are not highly pure (Comparative Example 1), ASA-2- which is a conventional high ASA derivative A solution containing the same molar amount of sodium phosphate (Comparative Example 2) and a placebo containing no high purity 2-O-3-G-ASA and 2-G-3-O-ASA of the present invention (Comparative Example) A solution obtained by sterilizing and filtering the aqueous solution 3) with a 0.2 μm membrane filter was added at 1: 1, and then freeze-dried to obtain porous spherical aggregate particles for bone repair. In addition to porous spherical particles for molded products such as medical supplies and quasi drugs, the porous spherical particles can be blended into various molded products as environmentally friendly biodegradable porous spherical particles. Can be pressed, porous spherical like food containers, bags, household goods, furniture, building materials, paint additives, film additives, vehicle frames, health food tablets, agricultural materials, clothing press products It could also be used as particles. Furthermore, active ingredients were mixed in porous spherical particles, and it could be used as fertilizer additives, food additives, feed additives, pharmaceutical DDS capsules, sludge treatment agents, waste oil decomposition treatment agents, and various industrial treatment bases. . The biodegradable product of the present invention is a chemical product, industrial product, civil engineering greening product, fertilizer, paint, cleaning material, agricultural and forestry product, horticultural material product, granule product, powder product, miscellaneous goods, clothing product, feed, Examples of foods, culture compositions, veterinary drugs, photosensitive materials, water treatment agents, and air purification agents. It is also an example of pharmaceuticals, quasi drugs, and unapproved pharmaceuticals.

   On the other hand, high purity 2-O-3-G-ASA and 2-G-3-O-ASA of the present invention were mixed with equimolar amounts of quaternary calcium phosphate (TeCP) and dicalcium phosphate (DCP). Mass% added (test section 1), non-high purity 2-O-3-G-ASA and 2-G-3-O-ASA containing the same amount (Comparative Example 1), conventional high ASA derivatives Containing the same molar amount of ASA-2-phosphate Na (Comparative Example 2) and high purity 2-O-3-G-ASA and 2-G-3-O-ASA of the present invention A self-hardening calcium phosphate cement paste for bone repair was prepared by kneading with ultra pure water containing a placebo (Comparative Example 3). When tested in a guinea pig bone defect model, the comparative sample 2 is about 3.4 times the comparative example 2 when the paste of the test section 1 of the present invention is used as compared with the comparative example 1, the comparative example 2 and the comparative example 3. The bone defect healed at a bone shape repair speed approximately 2.1 times faster than 1.

   Next, the self-hardening type calcium phosphate cement paste mixed with the aggregate particles so as to be 80 vol% was kneaded so as to incorporate air bubbles into the paste, and prepared based on the CT data of the bone defect portion. It was filled in an impression mold having a bone defect site shape and allowed to stand at room temperature in the air for 24 hours to obtain a cemented body having a bone defect site shape. By the above method, a calcium phosphate porous body having a bone defect site shape as an example of the ASA derivative-containing composition of the present invention could be obtained. This calcium phosphate porous material can be added to or processed into various molded products as an environmentally friendly biodegradable calcium phosphate porous material in addition to calcium phosphate porous materials for molded products such as medical supplies and quasi drugs. Because it is strong, calcium phosphate porous press-molded products that can be added to various containers, industrial frames, bags, household goods, furniture, building materials, film additives, health food tablets, agricultural materials, clothing, etc. It could also be used as a body. Furthermore, active ingredients were mixed in the calcium phosphate porous material, and it could be used as fertilizer additives, food additives, feed additives, pharmaceutical DDS capsules, sludge treatment agents, waste oil decomposition treatment agents, and various industrial treatment bases. This composition is a chemical product, industrial product, civil engineering planting product, fertilizer, paint, cleaning material, agricultural and forestry product, horticultural material product, granule product, powder product, miscellaneous goods, clothing product, feed, food, culture composition Examples of animal drugs, photosensitive materials, water treatment agents, and air purification agents. Furthermore, it is also an example of a composition for external use of pharmaceuticals, quasi drugs, and unapproved pharmaceuticals.

In this calcium phosphate porous body, macropores of about 100 μm and micropores of several microns were distributed. Moreover, the said macropore was couple | bonded by the micropore in adjacent aggregate particle | grains, and formed the communicating-hole network. When tested in a guinea pig bone defect model, compared to the conventional material containing no ASA derivative and the group in which the same amount of ASA was added instead of the ASA derivative, the porous body of the present invention was used, compared to Comparative Example 2. The bone defect was healed at a bone shape repair speed of about 2.9 times and about 1.9 times faster than Comparative Example 1. Furthermore, although the numerical value is not described in the above result, the result obtained by uniformly dispersing fibroblast growth factor (FGF), glycyrrhizic acid 2K, benzalkonium chloride, dl-α-tocopheryl phosphate Na is also obtained. It was much better than the comparative example.
The effects of the present invention are also examples of medical devices, medical devices, treatment devices, unapproved medical devices, and veterinary medical devices.

   Hydroxyapatite (HA) prepared to a particle size of 50 μm or less was mixed with 1 wt% sodium alginate aqueous solution so as to be 10 wt% to obtain a uniform slurry. This slurry was formed into a spherical shape by dropping 4 μl each into a 1 wt% calcium chloride aqueous solution. The spherical HA molded as described above was dried at 60 ° C. for 12 hours and then sintered at 1250 ° C. for 1 hour to obtain spherical aggregate particles having a diameter of 1 ± 0.2. About 55 vol% of the aggregate particles are put on a commercially available self-setting calcium phosphate cement powder, 0.5 wt% of the high purity 2-O-3-G-ASA of the present invention, and 2-G-3-O-ASA 0.5 wt%. %, And the mixture is filled into a laminated tube having a screw mouth, the screw mouth is sealed, and the ASA derivative-containing polymer composition for wound healing according to the present invention is an example of a bone healing polymer composition. Got. Furthermore, 10 g of fibroblast growth factor (FGF), 10 mg of glycyrrhizic acid, 1 mg of benzalkonium chloride, and 10 mg of dl-α-tocopheryl phosphate Na were separately prepared separately in 1 g of the above structure. Then, the cement kneading liquid is injected into the laminate tube from the sealing portion using a syringe, the cement is paste-formed in the laminate tube, and the tube filling for bone repair is an embodiment containing the ASA derivative of the present invention. It was a thing. A 16G injection needle was attached to the screw port of the tube filling prepared as described above to obtain an injector. In the cement injector, the aggregate composite cement paste contained therein could be easily discharged by pressing the tube. Moreover, the tube filling material was loaded into a syringe to obtain a polymer composition injector for bone repair, which is an example of the composition containing the ASA derivative of the present invention. In the cement injector, the aggregate composite cement paste to be included could be discharged by the same method as that for a normal syringe. Further, microbubbles made of nitrogen were blown into the paste so that a hollow structure could be formed. This composition is a chemical product, industrial product, civil engineering planting product, fertilizer, paint, cleaning material, agricultural and forestry product, horticultural material product, granule product, powder product, miscellaneous goods, clothing product, feed, food, culture composition Examples of animal drugs, photosensitive materials, water treatment agents, and air purification agents. Furthermore, it is also an example of a composition for external use of pharmaceuticals, quasi drugs, and unapproved pharmaceuticals. The present invention is also examples of medical devices, medical devices, treatment devices, unapproved medical devices, and veterinary medical devices.

(Sheet)
It is made from commercially available gelatin, starch (starch), sodium alginate, agar, cellulose, polyglutamic acid, chitin chitosan, konjac, paper, cotton woven fabric and silk woven fabric. Each square sheet is immersed in an aqueous solution containing 0.5 wt% of high purity 2-O-3-G-ASA and 0.5 wt% of 2-G-3-O-ASA of the present invention for 24 hours. Lyophilized to prepare a sheet which is an example of the ASA derivative-containing composition of the present invention. This sheet is biodegradable.
Furthermore, an adhesive component consisting of collagen or benzyl alcohol, castor oil, ethyl acetate, and ethanol was applied to these sheets to obtain bioadhesive films. Furthermore, 10 g of fibroblast growth factor (FGF), 10 mg of glycyrrhizic acid, 1 mg of benzalkonium chloride, and 10 mg of dl-α-tocopheryl phosphate Na were prepared in 1 g of the above structure. This biodegradable sheet can be applied to various products as an environmentally friendly biodegradable sheet in addition to sheets for medical supplies and quasi drugs, food containers, bags, household goods, furniture, building materials, paints Additives, film additives, food materials, agricultural materials. Furthermore, active ingredients were mixed into the above sheet, and it could be used as fertilizer additives, food additives, feed additives, pharmaceutical DDS capsules, sludge treatment agents, waste oil decomposition treatment agents, and various industrial treatment bases.

This composition is a chemical product, industrial product, civil engineering planting product, fertilizer, paint, cleaning material, agricultural and forestry product, horticultural material product, granule product, powder product, miscellaneous goods, clothing product, feed, food, culture composition Examples of animal drugs, photosensitive materials, water treatment agents, and air purification agents. Furthermore, it is also an example of a composition for external use of pharmaceuticals, quasi drugs and unapproved pharmaceuticals.
The present invention is also examples of medical devices, medical devices, treatment devices, unapproved medical devices, and veterinary medical devices.

(Sheet effect test)
For the guinea pig liver excision model (1/3 weight of the liver was excised with a laser knife), the protective sheet of Example 64 of the present invention was used, and the entire liver including the liver excision site was 0.5 g / square cm. Cover the sample completely, measure the period until the liver completely regenerates, the same material without the conventional ASA derivative, and the same amount of ASA phosphate added in place of the ASA derivative, and the ASA derivative In addition, the conventional 2-O-3-G-ASA and the same amount of 2-G-3-O-ASA which were not the present invention were compared. As a result, the same amount of conventional 2-O-3-G-ASA and 2-G-3-O-ASA, which is not the present invention, was added about 2.5 times as much as the group in which the same amount of ASA sodium phosphate was added. The liver was completely regenerated at a speed about 1.5 times faster than the ward. The effects of the present invention are also examples of medical devices, medical devices, treatment devices, unapproved medical devices, and veterinary medical devices.

   The present invention not only retains the physiological activity of ASA in vivo, but also prevents the oxidative degradation of peptides and physiologically active substances having a wound healing effect, and the problem of oxidative degradation of drugs in the sterilization process necessary as a pharmaceutical material It was confirmed that the wound healing promoter can be stably blended for a long period of time. The addition of ASA derivatives also makes it possible to increase the heat resistance and drug resistance of biodegradable plastics, etc., suppressing the generation of ASA radicals associated with the natural oxidation of ASA, and suppressing the occurrence of side effects such as inflammation. The effect of the wound healing promoter blended in the biodegradable plastic could be stably maintained for a long time after sterilization. Furthermore, it was confirmed that these drugs are supplied from the thread or the resin surface for a long time into the living body and the wound healing effect is sufficiently exhibited, and the occurrence of side effects such as keloid and inflammation is drastically reduced. Furthermore, the biodegradable sheet containing the active ingredient of the present invention is not only a biodegradable material for molded products such as medical supplies and quasi-drugs, but also as an environmentally friendly biodegradable material only for the medical field. It could also be used as various industrial materials such as sundries, clothing, food, agriculture, architecture, and civil engineering.

10 ppm each of the oil agent selected from the group B is mixed, and 10 ppm each of the oil agent selected from the surfactant of the group C is mixed and kneaded sufficiently. Liquid. Separately, 10 ppm of each of the following group A thickening polymer compounds was added to 50 g of an aqueous solution, and the mixture was divided into a filtered back solution and a residue. To this filtrate, 2-G-3-O-ASA of the present invention (product of the present invention) or 2-O-3-G-ASA (product of the present invention), conventional 2-G-3-O-ASA (product of the present invention) Comparison product) 2-G-3-O-ASA (comparison product), ASA (comparison product) or 2-phosphate ASANa (comparison product) 1% each, then selected from group D described below 10 ppm each of an antioxidant, an ultraviolet absorption shielding agent selected from the E group, a fungus growth inhibitory substance selected from the F group, and a viscosity stabilizing substance selected from the pH adjusting substance selected from the G group, After adding the liquid A, water was added to make 100 g. Each of these viscosities was measured and stored at a temperature of 50 ° C. for one month, and then the viscosity was measured again and compared with the viscosity at the start. In the order of the following solvents, the above residue is dissolved in 20 ml of solvent, the insoluble matter is filtered and further dissolved in the next solvent, and all solvents are used. The solvent and order are dimethyl sulfoxide, acetone, toluene, hexane, decahydronaphthalene. 20 ml of each of these solvents is divided into two, and 10 ml of one of them is added to 2-G-3-O-ASA of the present invention (Product of the present invention) or 2-O-3-G-ASA (Invention of the present invention). Product), 2 g of glycerin was added to the other 10 ml, and the respective viscosities were measured. After storing them at a temperature of 50 ° C. for 1 month, the viscosities were measured again and compared with the starting viscosity. The viscosity at the start of the experiment was taken as 100%, the viscosity at the end of the experiment was measured, and the rate of change in viscosity was summarized in Table 13. From these results, the rate of change of 2-G-3-O-ASA (product of the present invention) or 2-O-3-G-ASA (product of the present invention) of the present invention is the highest compared to the respective comparison products. It is confirmed that 2-G-3-O-ASA (product of the present invention) or 2-O-3-G-ASA (product of the present invention) of the present invention stabilizes the viscosity of the thickening substance. It was.

Group A: Thickening polymer
(Alkyl acrylate / diacetone acrylamide) copolymer, (alkyl acrylate / diacetone acrylamide) copolymer AMP, (acrylates / stearyl acrylate / ethylamine methacrylate oxide) copolymer, (dimethicone / vinyl dimethicone) crosspolymer, (meth) acrylic The copolymer of the acid alkyl ester includes (methacryloyloxyethylcarboxybetaine / alkyl methacrylate) copolymer, 1,2-butanediol, 1,2-propanediol, 1,2-hexanediol, 1,2-pentanediol, 1,2,3-hexanetriol, 1,2,3-pentanetriol, 1,2-hydroxystearic acid, 1,3-butanediol, 1,3-butylene glycol, 1,3-propanediol, 1,3 − Xanthdiol, 1,3-pentanediol, 1,3,4-hexanetriol, 1,3,4-pentanetriol, 1,3,5-hexanetriol, 1,3,5-pentanetriol, 1,3- Butylene glycol, 1,3-propanediol, 1,4-butanediol, 1,4-hexanediol, 1,4-pentanediol, 1,4,6-hexanetriol, 1,5-hexanediol, 1,5 -Pentanediol, 1,6-hexanediol, 2-amino-2-methyl-1,3-propanediol, 2-ethyl-1,3-hexanediol, 2-ethylhexyl acrylate, 2,3,4-pentanetriol 2-ethylhexyl acrylate, 2-ethylhexyl methacrylate, 2-hydroxyethyl (meth) acrylate, 2- Tyl-1,3-propanediol, 3-methyl-1,3-butanediol, EVA / PVC / graft copolymer, n-octyl acrylate, N-lauroyl-L-glutamic acid, PGA-PLA polymer, α -Various silicone copolymers such as methylstyrene, β-alanine, β-glucan, ionomer resin, acrylic-silicone graft copolymer, acrylamide, acrylic elastomer, acrylic acid, 2-ethylhexyl acrylate / methacrylic acid- 2-ethylhexyl / dodecyl methacrylate copolymer, acrylic acid / cationized methacrylic acid amide copolymer, acrylic acid / cationized methacrylic acid ester copolymer, acrylic acid / alkyl methacrylic acid copolymer, acrylic acid・ Methacrylate copolymer, alkyl acrylate ester, methyl acrylate 2-ethylhexyl acrylate copolymer resin emulsion, acrylic resin alkanolamine, acrylic resin emulsion, acrylonitrile, acrylonitrile-butadiene rubber, acylated peptide, acylated peptide and other protein peptides, asparagine, aspartic acid, atelocollagen, amine ionomer, alanine , Gum arabic, arabitol, arabinose, arabinogalactan, arginine, alginic acid, sodium alginate, propylene glycol ester alginate, albumin, aloe extract, Isaiyobara extract, isooctyl acrylate, isooctyl methacrylate, isodecyl acrylate, isodecyl methacrylate, iso Nonyl acrylate, isobutyl acrylate, isobutyl methacrylate, Sopentanediol, isoleucine, inositol, urethane elastomer, aerostin, ethyl glucoside, ethyl cellulose, ethyl methacrylate, ethylene, ethylene-α-olefin copolymer, ethylene-ethyl acrylate copolymer, ethylene-vinyl sulfonic acid copolymer Ionomer, ethylene-methacrylic acid copolymer ionomer, ethylene-vinyl acetate copolymer, ethylene-acrylic acid copolymer ionomer, ethylene glycol, ethylene glycol / propylene glycol copolymer, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether , Alkylethylmethanol (meth) acrylamide such as ethoxymethylacrylamide, elastin, elastin degrading peptide, erythritol, Octyl acrylate, octenyl succinate corn starch aluminum, curdlan, casein, casein-degrading peptide, cationic polymer, cationized oligosaccharide, cationized dextran, gypsum extract, gums, chamomile extract, carrageenan, carrageenan gum, galactan, galactitol, galactose, Galactomannan, Karaya gum, carboxyvinyl polymer, carboxymethylcellulose and its sodium salt, carboxymethyl starch, caroline sulfate, licorice extract, xanthan gum, xylitol, xylose, chitin, chitin / chitosan polymer, chitosan, cara gum, guar gum, guar Cationized polysaccharides such as hydroxypropyltrimonium chloride, Queensseed, glycogen, Lysine-binding peptide, glucose, glucomannan, monomer having carboxyl group including crotonic acid, aluminum magnesium silicate complex, sodium magnesium silicate complex, keratin-degrading peptide, keratosulfuric acid complex, gellan gum, sesame lignan glycoside, wheat Starch, rice starch, collagen, collagenolytic peptide, conchiolin degrading peptide, chondroitin sulfate, chondroitin sulfate sodium, chondroitin sulfate, comfrey extract, succinoglucan, xanthan gum, di-n-butylamine, diacetone acrylamide Monomer having dialkyldimethylammonium sulfate, dialkyl phosphate metal salt complex, alkyl (meth) acrylamide such as diethyl acryl, diethyl Glycol, diethylene glycol dibutyl ether, diethylene glycol monoethyl ether, diethylene glycol monomethyl ether, gellan gum, diglycerin complex, cyclodextrin, cystine complex, cysteine complex, dipropylene glycol, dibenzylidene sorbitol, dipentaerythritol, dimethylacrylamide, dimethyl Monomers having amino groups including amino acrylate, dimethyl dioctadecyl ammonium montmorillonite clay complex, dimethylbenzyl dodecyl ammonium montmorillonite clay complex, sucrose stearate ester, sucrose palmitate ester, sucrose fatty acid ester, silicone elastomer polyester, Silicone polymer, silicone oil, silylated polymer Peptide, silk extract, silk proteolytic peptide, white jellyfish polysaccharide, white jellyfish extract, styrene, styrene-isoprene-styrene block copolymer (SIS), styrene-ethylene / butylene-styrene block copolymer (SEBS), styrene-ethylene / propylene- Styrene block copolymer (SEPS), styrene-butadiene acrylic acid copolymer ionomer, styrene-butylene-styrene block copolymer (SBS), styrene-methacrylic acid copolymer ionomer, styrene-isoprene-styrene block copolymer, styrene-isoprene -Butylene block copolymer, styrene-isoprene copolymer, styrene-butadiene copolymer, styrene copolymer, styrene resin, stearyl acrylate, stearyl methacrylate Glycosphingolipid, sulfonated ethylene-propylene-diene copolymer ionomer, sulfonated styrene-2-acrylamido-2-methylpropane sulfate ionomer, sulfonated polystyrene ionomer, threonine complex, gelatin, ceramide, serine complex, Cellulose, sodium cellulose sulfate, sorbitol, taurine, tamarind, tara gum, tuberose polysaccharide, tyrosine complex, deoxyribose, dextran, dextrin, dextrin 2-ethylhexanoic acid palmitate, dextrin stearate, dextrin palmitate, dextrin Fatty acid ester, dextrin fatty acid ester complex, decyl acrylate, decyl methacrylate, dermatan sulfate, Rick polybutadiene acrylate ionomer, starch, corn starch, tragacanth gum, triethylene glycol, tryptophan complex, trimethylglycine complex, trimethylolpropane, threitol, threose, trehalose, troolloi, nylon, nylon resin, nitrocellulose, hydroxyapatite Polymers, hydroxypropyl (meth) acrylate, hamamelis extract, valienamine complex, validatol complex, validadamine complex, valine complex, palmitoyl oligopeptide, palmitoyl tetrapeptide, palmitoyl pentapeptide, potato starch, panthenol, hyaluron Acid, sodium hyaluronate, histidine complex, hydroxyalkylated cyclodextrin, hydroxy Ethylcellulose, hydroxyceramide, hydroxypropylcellulose, hydroxypropylcellulose or salts thereof, hydroxyproline, hydroxymethyl and hydroxypropylcellulose, vinylpyridone / vinyl alcohol copolymer, vinylpyrrolidone, vinylpyrrolidone / dialkylaminoalkyl methacrylate copolymer, hypotaurine , Furceleran, phenylalanine complex, fucoidan, fucose, butadiene complex, butyl acrylate, butyl methacrylate, butylene-acrylic acid copolymer ionomer, fluorine ionomer, fluorine polymer, butoxymethylacrylamide, fructooligosaccharide fatty acid ester, fructose, Pullulan, propylene, propylene-α-olefin copolymer, propylene Crylic acid copolymer ionomer, propylene-methacrylic acid copolymer ionomer, propylene glycol, hexyl acrylate, hexylene glycol, pectin, pectic acid, hectorite, betaine, loofah water extract, heparin, peptide, benzylidene derivative, pentaerythritol , Pentylene glycol, bentonite complex, phosphorylcholine, poly-β-hydroxybutyric acid (PHB), poly-β-hydroxybutanoic acid (PHB) and other poly (β-hydroxyalkanoates), poly-ε-caprolactone (PCL), Poly (ω-hydroxyalkanoate) such as poly-ε-caprolactone (PCL), poly (α-hydroxyacid) polymer, poly (β-hydroxyalkanoate) polymer, poly (ω-hydroxyalkanoate) , Poly (vinyl trimethyl) Ruammonium salt) ionomer, poly (vinylpyridinium salt) ionomer, poly (vinylbenzylphosphonium salt) ionomer, poly (meth) acrylic acid ester, polyacrylamide, polyacrylic alkyl ester emulsion, polyacrylic acid, polyacrylic acid-2 -Ethylhexyl, polyacrylic acid-2-ethylhexyl-N-vinyl-2-pyrrolidone-dimethacrylic acid-1,6-hexane glycol copolymer, polyacrylic acid-2-ethylhexyl-vinyl acetate-acrylic acid copolymer, Polyacrylic acid-2-ethylhexyl / vinyl acetate copolymer, polyacrylic acid / octyl acrylate ester copolymer, polyacrylic acid ester emulsion, polyethyl acrylate copolymer such as polyethyl acrylate, polyacrylic hydride Roxyethyl, polybutyl acrylate, polymethyl acrylate, polyamide, polyamide polymer, polyamino acid polymer, polyalkylene alkanoate, polyisobutylene, polyisoprene, polyurethane, polyurethane ionomer, polyurethane elastomer, polyurethane copolymer, polyester , Polyester polymers, polyethylene, polyethylene-polyamide graft copolymer, polyethyleneimine, polyethylene glycol, polyethylene succinate (PES), polyalkylene alkanoates such as polyethylene succinate (PES), polyethylene terephthalate, polyethylene terephthalate (PET) ), Polyethylene terephthalate copolymer, polyethylene naphthalate (PEN), polyethylene naphthalate copolymer, etc. Acrylic acid / diallyl such as polyester resin, polyoxyethylene / polyoxypropylene copolymer, acrylic acid / diallyldimethylammonium chloride copolymer such as polyolefin, polyquaternium-10, cationized cellulose, polyquaternium-22, and polyquaternium-39 Dimethylammonium chloride / acrylamide copolymer, acrylic acid / methyl acrylate / methacrylamidopropyltrimethylammonium chloride copolymer such as polyquaternium-47, polyquaternium-51,2-methacryloyloxyethyl phosphorylcholine polymer, polyquaternium-7, diallyl Dimethylammonium chloride / acrylamide copolymer, polyglycolic acid (PGA), polyglycine, polyglycerin, polyglucuronic acid, polyglycol Conic acid, polyglutamic acid, polydioxanone polymer, polytetrafluoroethylene, polytetrafluoroethylene polymer, polyvinyl alcohol, polyvinyl alcohol (PVA), polyvinyl ether, polyvinyl pyridone (PVP), polyvinyl pyrrolidone, polyvinyl methyl ether, Polybutadiene, polybutylene succinate (PBS), polybutylene terephthalate (PBT), polybutylene terephthalate copolymer, polypropylene, polypropylene, polypropylene-polyamide graft copolymer, polypropylene glycol, polypentamer ionomer, polymethacrylic acid-2 -Ethylhexyl, polyvinylidene chloride, polyvinyl chloride, polynucleic acid polymer, polyvinyl acetate resin emulsion, polyvinyl acetate fraction saponified product, Reglycosyl chains, poly (α-hydroxy acids) such as polylactic acid (PLA) and polylactic acid (PLLA), maltitol, maltose, maltosylated cyclodextrins, maleic acid monoalkyl esters such as maleic acid and butyl maleate, maleic Copolymers with acid copolymers, mannan, mannitol, mannose, dextrin myristic acid, mucoitin sulfate, mucopolysaccharide, alkyl methacrylate ester, methacrylate ester copolymer, glucosylethyl methacrylate copolymer, butyl methacrylate copolymer, etc. Polymers, α-β unsaturated carboxylic acids such as methacrylic acid, methionine, starch polymers such as methyl cellulose, methyl starch, methyl hydroxypropyl cellulose, methyl hydroxypropyl starch, methyl methacrylate, methyl methacrylate-butadiene Tylene resin, merryrot extract, monobenzylidene sorbitol, eucalyptus extract, lauryl acrylate, lauryl methacrylate, lauroyl hydrolyzed silk sodium, lactitol, lactose, raffinose, laminitol, lysine, ribitol, ribose, calcium phosphate polymer, leucine, locust bean gum, Fumed silica, choline chloride, hydroxypropylammonium chloride hydrolyzed collagen, hydroxypropyltrimonium chloride, vinyl chloride, chloromethacrylate choline ester polymer, hydrolyzed keratin, hydrolyzed collagen, hydrolyzed conchiolin, hydrolyzed silk, hydrolyzed Degraded wheat protein, plasticized polyvinyl chloride, plasticized vinyl acetate-vinyl chloride copolymer, nucleic acid, agar, agar gum, pseudo-serum Mido, bovine submandibular gland mucin, extremely low density polyethylene, metal soap, yeast extract, high density polyethylene, synthetic latex-containing polymer emulsion, aliphatic polyester water-absorbing resin, aliphatic ionene, wheat proteolytic peptide, Cellulose acetate, vinyl acetate, vinyl acetate-ethylene copolymer resin, hydrogenated polypentamer ionomer, hydrogenated styrene-isopropylene-block copolymer, water-dispersible polyester, linear low density polyethylene, polyhydric alcohol, placenta Extract, soybean proteolytic peptide, medium density polyethylene, ultrafine silica, low density polyethylene, natural rubber, natural rubber latex, natural moisturizing factor complex, naturally derived polysaccharide, sugar alcohol, sugar ceramide, sodium lactate, lactic acid bacteria Culture broth, whey, clay mineral complex, aromatic ionene, Water complex silicates, eggshell membrane protein, konjac gum, and salts selected these Na, Ca, K, Al, Mg, from Zn.

Group B: Oil
(Aminoethylaminopropylmethicone / dimethicone) copolymer, (isostearic acid / sebacic acid) ditrimethylolpropane, (hydroxystearic acid / stearic acid / rosinic acid) dipentaerythrityl, (hexyldecanoic acid / sebacic acid) diglyceryl oligoester, 12-hydroxy Stearic acid, cholesteryl 12-hydroxystearate, cetyl 2-ethylhexanoate, triglycerides 2-ethylhexanoate, di-N-lauroyl-L-glutamate (cholesteryl / octyldodecyl), di-N-lauroyl-L-glutamate (cholesteryl / Behenyl / octyldodecyl), N-lauroyl-L-glutamate di (phytosteryl / octyldodecyl), N-lauroyl-L-glutamate di (phytosteryl / behenyl / octyldodecyl), N-laur Acyl sarcosine alkyl esters such as irsarcosine isopropyl, α-olefin oligomer, almond extract oil, almond oil, iris extract oil, ashitaba extract oil, isopropyl adipate, diisobutyl adipate, diisopropyl adipate, asalo extract oil, asparagus extract oil , Avocado extract oil, avocado oil, avocado oil fatty acid ethyl, amatcha extract oil, linseed oil, aminopropyl dimethicone, amino acid modified silicone, amino modified and polyether modified silicone, amodimethicone, alkyl ether modified silicone, alkyl modified silicone, alkyl modified And polyether-modified silicone, Altea extract oil, Arnica extract oil, Aloe extract oil, Apricot kernel extract oil, Apricot extract oil, Anteisohenicosanoic acid, Isostearylco Lesteryl ester, isostearic acid, isopropyl isostearate, octyldodecyl isostearate, cholesteryl isostearate, phytosteryl isostearate, isostearic acid hardened castor oil, isotridecyl isononanoate, isononyl isononanoate, octyl isononanoate, isohexadecanoic acid, ginkgo extract oil, Inch Kou Extract Oil, Fennel Extract Oil, Oolong Tea Extract Oil, Turmeric Extract Oil, Horse Oil, Walnut Extract Oil, Undecylenic Acid, Eicosapentaenoic Acid, Ages Extract Oil, Echinacea Leaf Extract Oil, Ethylene / Propylene Copolymer, Erucic Acid, Octyl Elcaate Dodecyl, enamel extract oil, ogon extract oil, buckwheat extract oil, auren extract oil, barley extract oil, octamethyltrisiloxane, cetyl octanoate, Hexyldecyl octoate, ozokerite, ginseng extract oil, Hypericum extract oil, Odori extract oil, Ononis extract oil, Dutch mustard extract oil, olive oil, olive-derived squalane, oleic acid, ethyl oleate, octyldodecyl oleate, oleyl oleate, Animal waxes such as cholesteryl oleate and orange luffy oil; liquid lanolin, orange extract oil, orange oil, cocoa butter, cocoa oil, oyster leaf extract oil, oyster leaf extract oil, cation-modified silicone, cation-modified and polyether-modified Silicone, Cuckoo extract oil, Chamomile extract oil, Oat extract oil, Carcade extract oil, Carnauba wax, Carnauba wax, Carnauba wax, Carboxylic acid modified silicone, Carrot extract oil, Kawara mugi extract oil, Licorice extract oil , Kiwi extract oil, kiou extract oil, jellyfish extract oil, quina extract oil, candelilla wax, candelilla wax, cucumber extract oil, kiri leaf extract oil, guanosine, guava extract oil, triethyl citrate, kukui nut oil, kujin extract oil , Gardenia extract oil, Kumazasa extract oil, Clara extract oil, Chestnut extract oil, Walnut extract oil, Grape seed oil, Grapefruit extract oil, Clematis extract oil, Chlorella extract oil, Mulberry extract oil, Gentianana extract oil, Gennoshoco extract oil, Koboku Extract oil, coenzyme A, coffee extract oil, cholic acid, bilberry extract oil, dioctyl succinate, burdock extract oil, sesame oil, rice bran fermentation extract oil, rice bran oil, rice extract oil, rice ferment extract oil, rice germ oil, collagen, Cholesterol, cholesterol oleate, comfrey extract Oil, Psycho Extract Oil, Saishin Extract Oil, Saitai Extract, Sasa Extract Oil, Safflower Oil, Saffron Extract Oil, Sapogenin, Saponins, Salmon Extract Oil, Salvia Extract Oil, Hawthorn Extract Oil, Sansha Extract Oil, Salamander Extract Oil, shea butter, glyceryl diisostearate, diglyceryl diisostearate, dimer linoleyl diisostearate, shiitake extract oil, diou extract oil, 2-butyl-2-ethyl-1,3-propanediol dioctanoate, neopentyl dioctanoate Glycol, propylene glycol dioleate, neopentyl glycol dicaprate, cyclomethicone (cyclic dimethylsiloxane, sycon extract oil, glycol distearate (ethylene glycol distearate), perilla extract oil, linden extract oil, dihydrocholestero , Dihydrolanosterol, diphenyldimethicone, dimethiconol, dimethiconol crosspolymer, dimethicone (dimethylpolysiloxane), dimethiconecopolyol, hexyldecyl dimethyloctanoate, citrus extract oil, peony extract oil, jatoba extract oil, ginger extract oil, ginger root extract Oil, birch extract oil, silicone rubber, silicone resin, horsetail extract oil, squalane, squalane, squalene, stearic acid, cholesteryl stearate, butyl stearate, stearoxypropyldimethylamine, stevia extract oil, stevia fermented product, sphingomyelin, etc. Sphingophospholipids, Kizuta Extract Oil, Hawthorn Extract Oil, Elderberry Extract Oil, Yarrow Extract Oil, Pepper Extract Animal properties such as oil, sage extract oil, mallow extract oil, diisopropyl sebacate, diethyl sebacate, dioctyl sebacate, dibutyl octyl sebacate, ceresin, ceresin wax, nematode extract oil, assembly extract oil, sucha akuhi extract oil, turtle oil Fats and oils: whale wax, dio extract, soybean extract, tiso extract, dimer dilinoleic acid (phytosteryl / isostearyl / cetyl / stearyl / behenyl), dimer dilinoleic acid (phytosteryl / behenyl), dimer dilinoleate (Isostearyl / phytosteryl), dimerinolinoleate diisostearyl, dimerlinolinoleate diisopropyl, dimerlinoleic acid dimerinolinoleil, dimerlinoleic acid hydrogenated castor oil, dimerinolinole hydrogenated logistic Condensate, dimer acid, thyme extract oil, dandelion extract oil, chigaya extract oil, clove extract oil, chimpi extract oil, camellia oil, camellia oil, tea tree oil, deca (erucic acid / isostearic acid / ricinoleic acid) polyglyceryl-8 , Decamethylcyclopentasiloxane, decamethylcyclopentasiloxane), decamethyltetrasiloxane, polyglyceryl tetraisostearate, pentaerythrityl tetraoctanoate, red pepper extract oil, red pepper extract oil, citrus extract oil, tonin extract oil, spruce extract Oil, spruce oil, corn oil, dokudami extract oil, docosahexaenoic acid, dodecamethylcyclohexasiloxane, tomato extract oil, tri (caprylic acid / capric acid) glyceryl, tri (caprylic acid / capric acid / myristic acid / stearic acid) ) Glyceryl, glyceryl triisostearate, trimethylolpropane triisostearate, ditrimethyloltriethylhexanoate, pentaerythrityl triethylhexanoate, glyceryl trioctanoate, trimethylolpropane trioctanoate, glyceryl trioleate, rapeseed oil, carrot extract oil , Garlic extract oil, octyldodecyl neodecanoate, isostearyl neopentanoate, isodecyl neopentanoate, isotridecyl neopentanoate, polyglyceryl-10 nonaisostearate, cholesteryl nonanoate, Novara extract oil, persic oil, birch extract oil, perfluorooctane, per Fluorinated oils such as fluorodecane and perfluoropolyether, palm kernel oil, palm oil, hibiscus extract oil, bacmond Extract oil, lotus extract oil, parsley extract oil, peppermint oil, hammelis extract oil, paraffin wax, parietalia extract oil, cetyl parimitate, palmitate, isopropyl palmitate, octyl palmitate, octyldodecyl palmitate, diethanolamide palmitate (Partamide DEA), palmitic acid monoethanolamide (partamide MEA), palmitooleic acid, tomato extract oil, pycnogenol, bisabolol, hydroxyalkyl dimer linoleyl ether, hydroxylanolin, hinoki extract oil, bifidobacteria extract oil, castor oil , Sunflower oil, loquat extract oil, Fischer-Tropsch wax, phytosterol, phenyl dimethicone, phenyl trimethicone, dandelion extract oil, fukinotou extract oil, bukuryo extract oil Butcher bloom extract oil, fluorine modified silicone, grape seed extract oil, grape extract oil, propolis, hazelnut oil, loofah extract oil, petrolatum, safflower extract oil, peppermint extract oil, peptide modified silicone, behenic acid, behenic acid, eicosan behenate Glyceryl diacid, phosphatidylinositol, phosphatidylethanolamine, phosphatidylglycerol, phosphatidylcholine, phosphatidylserine, phosphatidic acid, body extract oil, button extract oil, hop extract oil, jojoba oil, polyisobutene, polyethylene wax, polyoxyethylene lanolin, polyglycerin modified Silicone, polysiloxane-oxyalkylene copolymer, polybutene, micaika extract oil, microcrystalline wax, macada Anut oil, macadamia nut oil, macadamia nut oil fatty acid cholesteryl, macadamia nut oil fatty acid phytosteryl, pine extract oil, maloni extract oil, beetle extract oil, beeswax, beeswax, mineral oil, myristic acid, isooctyl myristate, isotridecyl myristate, isopropyl myristate, isopropyl myristate Methylphenyl silicone oil such as octadecyl myristate, octyldodecanol myristate, octyldodecyl myristate, hexyldecyl myristate, myristyl myristate, mink oil, mucrose extract, methylcyclopolysiloxane, methylphenylpolysiloxane, methylpolycyclo Cyclic silicone oil such as siloxane; polyether-modified silicone oil, methylpolysiloxane, meadow foam oil, melissa Extracted oil, Owl oil, Mozuku extract oil, Oxyacid esters such as monoalcohol carboxylic acid ester, monoisostearic acid hydrogenated castor oil, peach extract oil, montan wax, cornflower extract oil, coconut oil, coconut oil fatty acid diethanolamide (cocamide) DEA), coconut oil fatty acid methylethanolamide (cocamide methyl MEA), coconut oil fatty acid monoethanolamide (cocamide MEA), eucalyptus extract oil, yukinoshita extract oil, yuzu extract oil, lily extract oil, yakuinin extract oil, mugwort extract oil, rice Wax, lauric acid, lauric acid diethanolamide (lauramide DEA), hexyl laurate, lauric acid monoisopropanolamide (lauramide MIPA), lauric acid monoethanolamide (lauramide MEA), lanosterol, lanolin, lanolin fatty acid, lanolin Phospholipids such as fatty acid isopropyl, lanolin fatty acid octyldodecyl, lavender extract oil, octyldodecyl ricinoleate, lysolecithin; hydrogenated soybean phospholipid, linoleic acid, linolenic acid, diisostearyl malate, apple extract oil, phosphate-modified silicone , Phospholipid / cholesterol complex, phospholipid / phytosterol complex, rooibos tea extract oil, litchi extract oil, lettuce extract oil, lemon extract oil, forsythia extract oil, forsythia extract oil, rosehip oil, rosemary extract oil, rose Extract oil, Roman chamomile extract oil, royal jelly extract oil, rosin triglyceride (ester gum), petrolatum, walnut extract oil, hydrolyzed elastin, hydrolyzed wheat powder, hydrolyzed silk, seawater dried product, seaweed extract oil, reduced lanolin, adsorption Purified Rano , Beef tallow, metal soaps, light liquid isoparaffin, whale wax, evening primrose oil, hydrogenated oil, hard lanolin fatty acid, hard lanolin fatty acid cholesteryl, black tea extract oil, yeast extract oil, highly polymerized dimethicone (high polymerized dimethylpolysiloxane), high Dimethyl silicone oil such as polymerized methylpolysiloxane; octamethylcyclotetrasiloxane, black rice extract oil, fatty acid modified silicone, fat-soluble brown sugar extract, fat-soluble black vinegar extract, heavy liquid isoparaffin, wheat germ oil, acetic acid (cetyl • Lanolins such as lanolinyl ester; lecithin, cholesteryl acetate, lanolin acetate, lanolin acetate alcohol, liquid lanolin acetate, hydrogenated dimer acid, hydrogenated castor oil, hydrogenated jojoba oil, hydrogenated coconut oil, hydrogenated rosin pentaeryth Lityl, hydrogenated egg yolk phospholipid, hydrogenated poly Sobutene, hydrogenated rosin triglyceride (hydrogenated ester gum), Nishi-Hayanagi extract oil, soybean oil, lichen extract oil, tea extract oil, tea oil, clove oil, long chain α-hydroxy fatty acid cholesteryl, long chain branched fatty acid, long Chain branched fatty acid cholesteryl, strawberry tea extract oil, sugar-modified silicone, soft lanolin fatty acid cholesteryl, cetyl lactate, milk fat, natto extract oil, horse fat, white mushroom extract oil, partially hydrogenated soybean phospholipid, partially hydrogenated egg yolk phospholipid, rice germ Oil, honey, beeswax, cottonseed oil, tree wax, beeswax, oil-soluble licorice extract oil, peanut oil, egg yolk oil, eggshell membrane extract oil, liquid paraffin, liquid paraffin (mineral oil), sulfate-modified silicone, green tea extract oil,

Group C: Surfactant
2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, N-acyl amino acid ester, N-acyl amino acid salt, N-dimethylamino acid betaine, PPG-9 diglyceryl, α-oleic acid pyroglutamate glycerin Α-olefin sulfonic acid sodium salt, α-sulfo fatty acid methyl ester salt, acrylic acid / alkyl methacrylate copolymer, acyl isethionate, sodium acyl glutamate, acyl lactate, aminopropyl dimethicone and amodimethicone, amino-modified and poly Ether-modified silicone, alkanesulfonate, alkylamine salt, alkylaryl ether phosphate, alkylisoquinolinium salt, alkyletheraminemonium salt, alkylethoxydimethylamine oxide, alkylglycidyl ether Sulfonate, alkyldimethylaminoethanol phosphate, alkyldimethylaminoethanol sulfate, alkyldimethyltaurine, alkylsulfoacetate, alkyltrialkylene glycol ammonium salt, alkylnaphthalenesulfonate, alkylbenzenesulfonate, alkylbenzene polyoxyethylene Sulfate, alkyl polyglycoside, sodium alginate, isostearyl glyceryl ether, glyceryl isostearate, polyglyceryl isostearate, isosteares (polyoxyethylene isostearyl ether), imidazolinium salt, undecylenic acid trehalose, ethyl lanolin fatty acid aminopropyl Ethyl dimethyl ammonium, ethyl sulfate long chain branched fatty acid (12-31) Nopropylethyldimethylammonium, octyldecesses (polyoxyethylene octyldodecyl ether), glyceryl oleate, polyglyceryl oleate-2, sodium caseinate, cationic modified silicone, cationic modified and polyether modified silicone, caprylyl glucoside, carboxylic acid modified silicone, Kimyl alcohol, cocamidopropyl betaine, cocamamine oxide, sodium cocoamphoacetate, cocoylalanine triethanolamine, cocoylglutamate triethanolamine, sodium cocoylglutamate, cocoylmethyltaurine potassium, cocoylmethyltaurine sodium, surfactin, saponin, dialkylmori Honium salt, polyglyceryl-2 diisostearate Lysyl), diglyceryl-6 dioleate, dicocodimonium chloride, distearyldimonium chloride, polyglyceryl-6 distearate, dimethicone copolyol, sucrose fatty acid ester, sodium dilaureth phosphate, stearamide ethyl diethylamine, stearamide propyldimethylamine, Stearamine oxide, stearyltrimonium bromide, glyceryl stearate, sodium stearate, polyglyceryl-2 stearate, steartrimonium chloride, steareth (polyoxyethylene stearyl ether) s, sodium stearoyl glutamate, stearoxypropyldimethylamine, sphingomyelin , Dioctyl sodium sulfosuccinate, disodium lauryl sulfosuccinate, sulfoco Laureth disodium, glyceryl sesquioleate, sodium cetyl sulfate, ceteth (polyoxyethylene cetyl ether) s, cetrimonium chloride, ceralkyl alcohol, sophorolipid, sorbitan sesquioleate, sorbitan trioleate, sorbitan monoisostearate, Sorbitan monooleate, sorbitan monostearate, sorbitan monopalmitate, sorbitan monolaurate, sorbitan fatty acid ester, sorbitol partial fatty acid ester, polyglyceryl-10 decaisostearate, polyglyceryl-10 decaoleate, polyglyceryl-10 decastearate, tetra -2-ethylhexyl diglycerol sorbitan, polyisoglyceryl tetraisostearate, tetradecylbenzenesulfo Acid triethanolamine, sodium tetradecylbenzenesulfonate, tetrapolyoxyethylene-tetrapolyoxypropylene-ethylenediamine condensates, starch derivatives, tragacanth gum, polyglyceryl-2 triisostearate, polyglyceryl-2 trioleate, polyglyceryl tristearate -2, sodium trilaureth phosphate, batyl alcohol, potassium palmitate, glyceryl palmitate, palmitate diethanolamide (partamide DEA), palmitate triethanolamine, palmitate monoethanolamide (partamide MEA), palmitoyl aspartate ditriethanol Amine, behenamine oxide, behenes (polyoxyethylene behenyl ether), behentrimonium chloride, benzal Nium salt, benzethonium salt, di-2-pentyl-2-ethylhexylate diglycerol sorbitan, pentaerythritol partial fatty acid ester, phosphatidylinositol, phosphatidylethanolamine, phosphatidylglycerol, phosphatidylcholine, phosphatidylserine, phosphatidic acid, polyamine fatty acid derivative, polyol fatty acid ester, polyoxy Ethylene / propylene glycol fatty acid ester, polyoxyethylene / polyoxypropylene 2-decyltetradecyl ether, polyoxyethylene / polyoxypropylene alkyl ether, polyoxyethylene / polyoxypropylene glycol, polyoxyethylene / polyoxypropylene glycerin ether, Polyoxyethylene / polyoxypropylene cetyl acetate Tellurium, polyoxyethylene / polyoxypropylene monobutyl ether, polyoxyethylene / polyoxypropylene hydrogenated lanolin, polyoxyethylene alkylamine, polyoxyethylene alkylamine and its salts or quaternary salts, polyoxyethylene alkyl ether, polyoxy Ethylene alkyl ether phosphoric acid, polyoxyethylene alkyl ether fatty acid ester, polyoxyethylene alkyl ether sulfate, polyoxyethylene alkyl phenyl ether, polyoxyethylene alkyl phenyl ether phosphoric acid, polyoxyethylene alkyl phenol ether, polyoxyethylene alkyl mercaptan, Polyoxyethylene glycerol triisostearate, polyoxyethylene glycerol monoisostearate, polio Siethylene glycerin monostearate, polyoxyethylene glycerin fatty acid ester, polyoxyethylene cholestanol, polyoxyethylene cholesterol, polyoxyethylene dioleate, polyoxyethylene distearate, polyoxyethylene sorbitan tetraoleate, polyoxyethylene Sorbitan monooleate, polyoxyethylene sorbitan monooleate, polyoxyethylene sorbitan monostearate, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene sorbitol pentaoleate, polyoxyethylene sorbitol beeswax, polyoxyethylene sorbitol monooleate, poly Oxyethylene sorbitol monostearate, polyoxyethylene sorbitol monolaurate Polyoxyethylene sorbitol fatty acid ester, polyoxyethylene castor oil, polyoxyethylene phytosterol, polyoxyethylene methyl glucoside fatty acid ester, polyoxyethylene monooleate, polyoxyethylene monooleate, polyoxyethylene sodium lauryl phosphate, polyoxy Ethylene lanolin, polyoxyethylenated sterol, polyoxyethylenated lanolin, polyoxyethylene reduced lanolin, polyoxyethylene hydrogenated castor oil, polyoxyethylene hydrogenated castor oil, polyoxyethylene hydrogenated castor oil triisostearate, polyoxyethylene hardened Castor oil maleic acid, polyoxyethylene hydrogenated castor oil monoisostearate, polyoxyethylene hydrogenated castor oil monopyroglutamic acid monoisostearate Allicic acid diester, polyoxyethylene fatty amine sulfate, polyoxyethylene fatty acid amide, polyoxyethylene fatty acid ester, polyglycerin-modified silicone, polysiloxane-oxyalkylene copolymer, polyethylene glycol diisostearate, polyvinyl alcohol, multi Tall ether, maltitol partial fatty acid ester, potassium myristic acid, glyceryl myristate, sodium myristoyl glutamate, sodium myristoyl methyl taurate, methyl glucoside fatty acid ester, glyceryl monoerucate, sodium monoolesate, ethylene glycol monostearate, ethylene glycol monostearate , Glyceryl monostearate, glyceryl monostearate, malic acid, monostearic acid Lopylene glycol, propylene glycol monostearate, monolauroyl monoethanolamide sodium polyoxyethylene sulfosuccinate, mono-cotton oil fatty acid glycerin, coconut oil fatty acid glyceryl, coconut oil fatty acid diethanolamide (cocamide DEA), coconut oil fatty acid methyl ethanolamide (cocamide methyl MEA) ), Coconut oil fatty acid monoethanolamide (cocamide MEA), lauramide propyl betaine, lauramine oxide, lauryldimethylaminoacetic acid betaine, lauryltrimonium chloride and other alkyltrimethylammonium chloride, laurylbetaine (lauryldimethylaminoacetic acid betaine), lauryl Polypropylene glycol sodium sulfosuccinate, potassium lauryl phosphate, ammonium lauryl sulfate, lauric Sulfate ester, lauryl sulfate triethanolamine, sodium lauryl sulfate, potassium laurate, lauric acid diethanolamide (lauramide DEA), lauric acid monoisopropanolamide (lauramide MIPA), lauric acid monoethanolamide (lauramide MEA), laureth (poly Oxyethylene lauryl ethers), sodium laureth phosphate, sodium laureth acetate, triethanolamine laureth sulfate, sodium laureth sulfate, sodium lauroamphoacetate, sodium lauroyl glutamate, sodium methylalanine lauroyl glutamate, lauroyl sarcosine triethanolamine, lauroyl sarcosine sodium, lauroyl Sodium methylalanine, sodium lauroylmethyltaurine, lauroy Amphoteric surfactants such as sodium monoethanolamide succinate, lanolin alcohol, lysolecithin, phosphate-modified silicone, lecithin, pyridinium salts such as distearyldimethylammonium chloride, stearyldimethylbenzylammonium chloride, stearyltrimethylammonium chloride, cetylpyridinium chloride, Benzalkonium chloride, benzethonium chloride, alkyldiaminoethylglycine hydrochloride, reduced lanolin, hydrogenated coconut oil fatty acid sodium glycerin sulfate, fatty acid amide ether phosphate, fatty acid amide guanidinium salt, fatty acid alkanolamide ether carboxylate, fatty acid alkanolamide Phospholipids such as sulfate, fatty acid alkylolamide, lipophilic glyceryl monooleate, and lecithin hydroxide, hydrogenated soybean phospholipid, Hydrogenated egg yolk phospholipid, polyhydric alcohol alkyl ether, sugar-modified silicone, partially hydrogenated soybean phospholipid, partially hydrogenated egg yolk phospholipid, sulfuric acid-modified silicone,

Group D: Antioxidant
BHA, BHT, β-carotene, γ-amino-β-hydroxybutyric acid, astaxanthin, acetoxyhydroxybenzoic acid, ellagic acid, erythorbic acid and its derivatives, chamomile extract, guaiac oil, kojic acid, diacetoxybenzoic acid, diisopropylamine dichloroacetate , Cysteamine, cysteine, cysteine hydrochloride, dibutylhydroxytoluene, Sakuhak extract, thioglycolic acid, thioglycolic acid, thioglycerol, thiotaurine, thiourea, sodium thiosulfate, thiosulfate, tocotrienol, tocopheryl acetate, tocopheryldimethyl Glycine, tocopheryl nicotinate, tocopheryl linoleate, tocopheryl phosphate Na, tocopherol, tocopherol (vitamin E), nordihydroguaiaretic acid, hydroquinone, Idroquinone glucoside, hydroquinone benzyl ether, retinol palmitate, hypotaurine, butylhydroxyanisole, butylhydroxyanisole, butylhydroxytoluene, butylresorcinol, metabisulfite, methylenebis (4-methyl-6-t-butyl) phenol, yukinoshita Extract liquid, resorcinol, retinoic acid, sodium sulfite, sulfite, sodium bisulfite and other bisulfites, hydrogen peroxide, percarbonate, ammonium persulfate, sodium bromate, tocopherol acetate, retinol acetate, placenta extract, rice bran extract , Gallic acid, propyl gallate, propyl gallate, gallic acid derivatives

Group E: UV absorption shielding agent
1,1-dicarboxy (2,2′-dimethylpropyl) -4,4-diphenylbutadiene, 1,1 ′-(1,4-piperazinediyl) bis [1- [2- [4- (diethylamino)- 2-hydroxybenzoyl] phenyl] -methanone, n-hexyl 2- (4-diethylamino-2-hydroxybenzoyl) benzoate, p-aminobenzoic acid (PABA) compound, dimer derived from α-alkylstyrene, β-diphenylacrylate compound , Alumina, anthranyl compound, imidazoline compound, ethylhexyl triazone, octocrylene, camphor benzilyl methosulfate, 4-methylbenzylidene camphor, camphor compound, cinnamic acid compound, ethylhexyl salicylate, salicylic acid, 4,4-diarylbutadiene, butylmethoxy Dibenzoylmethane, diethylhexylbutamide triazone , Dineopentyl 4'-methoxybenzalmalonate, dibenzoylmethane compound, silane, silica, silicone, terephthalylidene dicamphorsulfonic acid, triazine compound, tris- (di-phenyl) -triazine, 2,4,6-tris (Dineopentyl 4′-aminobenzalmalonate) -s-triazine, 2,4,6-tris (diisobutyl4′-aminobenzalmalonate) -s-triazine, 2,4,6-tris- (ter- Phenyl) -triazine, 2,4,6-tris- (di-phenyl) -triazine, drometrizole trisiloxane, bis-ethylhexyloxyphenol methoxyphenyl triazine, bis-benzoazolyl compound, bis [5-1 (dimethylpropyl) Benzoxazol-2-yl- (4-phenyl) imino] -6- (2-ethylhexyl) imino-1,5-triazine, phenyldibenzoi Midazol tetrasulfonate disodium, 2,4-bis- (n-butyl 4'-aminobenzalmalonate) -6 [(3- {1,3,3,3-tetramethyl-1-[(trimethylsilyl Oxy) -disiloxanyl] propyl} amino) -s-triazine, 2,4-bis [5-1 (dimethylpropyl) benzoxazol-2-yl- (4-phenyl) imino] -6- (2-ethylhexyl) imino -1,3,5-triazine, phenylbenzimidazole sulfonic acid, benzalmalonate compound, benzimidazole compound, benzoxazole compound, benzotriazole compound, benzophenone-3, benzophenone-4, benzophenone-5, benzophenone compound, homosalate, Polysilicone-15, methylbenzylidene camphor, methylenebis-benzotriazolyltetramethylbutylphenol, methylene (Hydroxyphenylbenzotriazole) compound, ethylhexyl methoxycinnamate, zirconium oxide, cerium oxide, titanium oxide (amorphous or rutile and / or anatase crystalline), zinc oxide, iron oxide, shielding polymer and Shielding silicone, aluminum hydroxide, 0.3

Group F: Bacterial growth inhibitor
1,2-hexanediol, 1,2-pentanediol, EDTA, EDTA2Na, EDTA3Na, EDTA4Na, HEDTA3Na, amphotericin B, alanine, isopropylphenol, imidazolinium urea, undecylenic acid, oxalamide, etidronic acid and other phosphonic acids, ethyl Paraben, ethyl alcohol, erythromycin, oxytetracycline, octanol, chlorhexidine gluconate, cresol, clotrimazole, chloramphenicol, chlorhexidine, salicylic acid, cyclopyroxolamine, siccanin, dihydroxyethylglycine, sodium oxalate, zinc pyrithione, sorbic acid , Thianthol, thymol, tetracycline, dehydroacetic acid, decanol, triclosanamide, trichlorocarbanide, tricomycin, tolnafu Tate, nystatin, nornaphthate, parachlorophenol, variotin, halocarban, haloprozin, hydroxyethylethylenediamine triacetate, hydroxybenzoic acid, hinokitiol, pimafucin, pyrrolnitrin, propyl alcohol, phytic acid, phenylethyl alcohol, phenylphenol, Sodium phenylphenol, phenyliodoundecinoate, phenol, phenoxyethanol, butyl paraben, butyl alcohol, propyl paraben, hexachlorophene, hexanol, heptanol, penicillin, pentamycin, pentanol, pentetate (diethylenetriaminepentaacetate), poly Aspartic acid, polyglutamic acid, sodium polyphosphate, sodium metaphosphate, methylisothia Linone, Methylchloroisothiazolinone, Methylparaben, Sodium benzoate, Benzalkonium chloride, Benzethonium chloride, Photosensitizers, Silver ions, Antibacterial zeolite, Isoconazole nitrate, Econazole nitrate, Omoconazole nitrate, Ketoconazole nitrate, Sulconazole nitrate, Thioconazole nitrate , Miconazole nitrate, fradiomycin sulfate,

Group G: pH adjusting substance 2-amino-2-hydroxymethyl-1,3-propanediol, 2-amino-2-methyl-1,3-propanediol, acrylamide-acrylic acid copolymer, alkaline earth metal water Oxides, arginine, alginic acid, ammonia, aqueous ammonia, isopropanolamine, citric acid, citric acid, sodium citrate, glycolic acid, succinic acid, diisopropanolamine, diethanolamine, diethylamine, dimethylamine, styrene-maleic anhydride copolymer Copolymer, starch-acrylic acid graft polymer, triisopropanolamine, triethanolamine, triethylamine, trimethylamine, fumaric acid, polyacrylic acid, polyaspartic acid, polyitaconic acid, polyethanolamine, polyglutamic acid, polyvinyl acetate -Crotonic acid copolymer, polyvinyl sulfonic acid, monoethanolamine, malic acid, trisodium phosphate, dipotassium hydrogen phosphate, disodium hydrogen phosphate, hydrochloric acid, tartaric acid, nitric acid, acetic acid, sodium acetate, vinyl acetate-( (Meth) acrylic acid copolymer, vinyl acetate-crotonic acid copolymer, potassium hydroxide, calcium hydroxide, sodium hydroxide, magnesium hydroxide, ammonium carbonate, guanidine carbonate, lactic acid, sodium lactate, sulfuric acid.

The present invention is not limited to pharmaceuticals, quasi-drugs, unapproved pharmaceuticals, cosmetics, but also chemicals, industrial products, civil engineering greening products, fertilizers, paints, cleaning materials, agricultural and forestry supplies, horticultural supplies, granule products, powders Goods, miscellaneous goods, clothing, feed, food, culture composition, veterinary medicine, medical equipment, medical equipment, treatment equipment, unapproved medical equipment, veterinary medical equipment, photosensitive material, water treatment agent, air purification agent, etc. Widely available.

Claims (15)

High-purity glyceryl octyl ascorbic acid characterized in that the total content of one kind selected from monoglyceryl ascorbic acid and monooctyl ascorbic acid and ascorbic acid is 3% by mass or less. When the peak area of glyceryl octyl ascorbic acid and the peak area other than glyceryl octyl ascorbic acid are measured by the automatic integration method of the liquid chromatogram, the peak area other than glyceryl octyl ascorbic acid is 5% or less of the total peak area. Item 1. High purity glyceryl octyl ascorbic acid according to item 1. It contains at least one selected from general formula (Chemical Formula 1) 2-O-glyceryl-3-O-octylascorbic acid and general formula (Chemical Formula 2) 2-O-octyl-3-o-glyceryl ascorbic acid. Item 1. High purity glyceryl octyl ascorbic acid according to item 1.

In a solution containing sodium chloride and disodium hydrogen phosphate, standard ascorbic acid or the same mole of glyceryl octyl ascorbic acid, hemoglobin and hydrogen peroxide of the present invention are added to cause Fenton reaction, and spin trapping agent is added. When the ascorbic acid radical intensity is measured as the peak height using an electron spin resonance spectrometer, the ascorbic acid radical intensity of glyceryl octyl ascorbic acid is 50% or less of the ascorbic acid radical intensity generated by the same mole of ascorbic acid. The high purity glyceryl octyl ascorbic acid according to claim 1. A process of hydrolyzing 3-O-octylascorbic acid under acidic conditions in the presence of 2-O-glyceryl-3-O-octylascorbic acid and 3-O-octylascorbic acid, and a solvent extraction method and column The method for producing high-purity 2-O-glyceryl-3-O-octylascorbic acid according to claim 1, wherein one or more extraction methods selected from chromatographic separation and extraction methods are combined. Step of hydrolyzing 3-O-glyceryl ascorbic acid under acidic conditions in the presence of 2-O-octyl-3-O-glyceryl ascorbic acid and 3-O-glyceryl ascorbic acid, extraction method using solvent and column The method for producing high-purity 2-O-octyl-3-O-glyceryl ascorbic acid according to claim 1, wherein one or more extraction methods selected from chromatographic separation and extraction methods are combined. Ascorbine with improved levels of lactate dehydrogenase, malate dehydrogenase, aspartate aminotransferase, and stress-ptothein, anti-lipid metabolism improving effect, liver function improving effect and antibody stress effect, with suppressed ascorbate radical generation An oral composition comprising the high-purity glyceryl octyl ascorbic acid according to claim 1 as an acid source. A composition comprising the high-purity glyceryl octyl ascorbic acid of claim 1 as an ascorbic acid source, which is any one selected from an oral composition, an in-vivo composition, and a chemical product. The high-purity glyceryl octyl ascorbic acid according to claim 1 is included as a source of ascorbic acid, which is any one selected from pharmaceuticals, quasi-drugs, medical culture drugs, medical devices, medical devices, unapproved pharmaceuticals, cosmetics, and animal products. A composition for external use in which ascorbic acid radical generation is suppressed. The product composition for external use according to claim 8, which is any one selected from the following product forms, includes eye shadow, eyebrow, eyeliner, insecte tripler, water grease, washing pack, essence, enamel remover, emollient cream. , Emollient lotion, elbow lotion, oil shampoo, oil pack, eau de cologne, eau de toilette, eau de parfum, color lotion, cream, cream shampoo, cleansing oil, cleansing cream, cleansing gel, cleansing foam, cleansing mask, cleansing milk, cleansing lotion, conditioning shampoo , Sunscreen, sunscreen cream, suntan cream, sun protector, sump Tect, Shaving Cream, Gel, Shampoo, Skin Moisture, Perfume, Straight Perm, Set Lotion, Chick, Deodorant Cream, Deodorant Stick, Deodorant Spray, Deodorant Powder, Deodorant Lotion, Toner, Treatment, Night Cream, Nourishing Cream, Nari Thing Milk, Nourishing Lotion, Nail Enamel, Nail Treatment, Perm After Treatment, Permanent Wave, Perm Pretreatment, Bath Oil, Pack, Vanishing Cream, Perfume, Parfum, Hand Lotion, Peel Off Pack, Foundation, Pre Makeup Cream, Protect Emulsion , Hair oil, hair color after treatment Hair color pretreatment, hair cream, hair gel, hair spray, hair tonic, hair pack, hair foam, hair bleach, hair blow, hair manicure, hair mist, mousse, hair liquid, hair wax, base cream, body powder, body shampoo, body Skin Lotion, Body Lotion, Pomade, Mascara, Massage Cream, Manicure, Massage Lotion, Milky Lotion, Milk, Mist, Steam, Makeup Cream, Makeup Lotion, Makeup Agent, Moisture Cream, Moisture Lotion, Moisture Lotion, Moisture Emulsion Lip gloss, liniment, liposome lotion, liposome serum, rinse, rinse shampoo, lotion, low Skin care agent, hair restorer, liquid soap, makeup base, lotion, cosmetic soap, keratin smoother, keratin softening cream, lipsticks, perfume soap, synthetic cosmetic soap, oxidative hair dye, UV protection essence, hair removal cream, soap, Facial cleansing powder, facial cleanser, detergent, washing powder, depigmenting agent, hair removal / hair removal agent, insect repellent spray, patch, transparent soap, ointment, milky lotion, white powder / dusting powder, eyebrow, whitening essence, powder pack, moisturizing Essence, fragrance powder, fragrance, deodorant cosmetic, blusher, hair coat agent, medicated soap, bath agent, shower agent, perfume, mask, socks, gloves, earplugs, hat, cap, socks, underwear, tights, Condom, tampon, napkin, ring, bracelet, collar, footband, earring, bandage, bandage, gauze, cloth, suture, skin tape, skin film, skin adhesive, skin stapler, Take paper, skin paper, clip for skin, skin for the film, skin ribbon, skin paint, skin for the non-woven fabric, string skin, yarn for the skin, the skin tube, patch test kit for the skin. From skin erythema improvement effect, stratum corneum moisture improvement effect, epidermis moisture transpiration improvement effect, contact dermatitis improvement effect, acne improvement effect, pathogenic skin resident microorganism suppression effect, pressure ulcer improvement effect The composition for external use of Claim 8 which has the improvement effect | action selected from any one of these. The ascorbic acid source according to claim 1 having excellent color tone and odor stability in an accelerated test in a long-term high temperature state where the temperature is 40 ° C. ± 2 ° C. and the humidity is 75% RH ± 5% RH for 6 months. The composition for external use of Claim 8 in which generation | occurrence | production of ascorbic acid radical containing the highly purified glyceryl octyl ascorbic acid was suppressed. An emulsified composition having a lamellar liquid crystal containing the high-purity glyceryl octyl ascorbic acid according to claim 1. The emulsification according to claim 13, which has any action selected from a whitening action, a free radical inhibiting action, an anti-wrinkle action, an anti-acne action, a moisturizing action, a barrier function enhancing action, an ultraviolet ray-derived inflammation inhibiting action, and an anti-decubitus action. Composition. A single or multiple thickeners selected from two groups of thickeners: a thickener polymer group consisting of one or more of the following Group A thickener polymers and a thickened emulsion composition group described below. A thickening composition comprising the above substances, glyceryl octyl ascorbic acid according to claim 1 as an ascorbic acid source, an antioxidant selected from group D described below, an ultraviolet absorption shielding agent selected from group E, and group F The composition for external use according to claim 8, wherein the viscosity of the thickening substance is stabilized by including at least one viscosity stabilizing substance selected from a fungus growth-inhibiting substance selected from the group 1, a pH adjusting substance selected from the G group. object
(Thickening emulsion composition group)
A thickened emulsion composition comprising one or more of the following Group B oil agents, one or more Group C surfactants, and water.
Group A: Thickening polymer
(Alkyl acrylate / diacetone acrylamide) copolymer, (alkyl acrylate / diacetone acrylamide) copolymer AMP, (acrylates / stearyl acrylate / ethylamine methacrylate oxide) copolymer, (dimethicone / vinyl dimethicone) crosspolymer, (meth) acrylic The copolymer of the acid alkyl ester includes (methacryloyloxyethylcarboxybetaine / alkyl methacrylate) copolymer, 1,2-butanediol, 1,2-propanediol, 1,2-hexanediol, 1,2-pentanediol, 1,2,3-hexanetriol, 1,2,3-pentanetriol, 1,2-hydroxystearic acid, 1,3-butanediol, 1,3-butylene glycol, 1,3-propanediol, 1, 3-hexanediol, 1,3-pentanediol, 1,3,4-hexanetriol, 1,3,4-pentanetriol, 1,3,5-hexanetriol, 1,3,5-pentanetriol, 1, 3-butylene glycol, 1,3-propanediol, 1,4-butanediol, 1,4-hexanediol, 1,4-pentanediol, 1,4,6-hexanetriol, 1,5-hexanediol, 1 , 5-pentanediol, 1,6-hexanediol, 2-amino-2-methyl-1,3-propanediol, 2-ethyl-1,3-hexanediol, 2-ethylhexyl acrylate, 2,3,4- Pentanetriol, 2-ethylhexyl acrylate, 2-ethylhexyl methacrylate, 2-hydroxyethyl (meth) acrylate , 2-methyl-1,3-propanediol, 3-methyl-1,3-butanediol, EVA / PVC / graft copolymer, n-octyl acrylate, N-lauroyl-L-glutamic acid, PGA-PLA Polymer, α-methylstyrene, β-alanine, β-glucan, ionomer resin, various silicone copolymers such as acrylic-silicone graft copolymer, acrylamide, acrylic elastomer, acrylic acid, 2-ethylhexyl acrylate -Methacrylic acid-2-ethylhexyl-Dodecyl methacrylate copolymer, Acrylic acid-Cationized methacrylic acid amide copolymer, Acrylic acid-Cationized methacrylic acid ester copolymer, Acrylic acid-Alkyl methacrylate copolymer Copolymerization, acrylic acid / methacrylic acid ester copolymer , Alkyl acrylate, methyl acrylate / acrylic acid-2-ethylhexyl copolymer resin emulsion, acrylic resin alkanolamine, acrylic resin emulsion, acrylonitrile, acrylonitrile-butadiene rubber, acylated peptide, protein peptide such as acylated peptide, asparagine , Aspartic acid, atelocollagen, amine ionomer, alanine, gum arabic, arabitol, arabinose, arabinogalactan, arginine, alginic acid, sodium alginate, propylene glycol ester of alginic acid, albumin, aloe extract, Isaiyobara extract, isooctyl acrylate, isooctyl methacrylate , Isodecyl acrylate, isodecyl methacrylate, isononyl acrylate, Sobutyl acrylate, isobutyl methacrylate, isopentanediol, isoleucine, inositol, urethane elastomer, aerostin, ethyl glucoside, ethyl cellulose, ethyl methacrylate, ethylene, ethylene-α-olefin copolymer, ethylene-ethyl acrylate copolymer, ethylene- Vinyl sulfonic acid copolymer ionomer, ethylene-methacrylic acid copolymer ionomer, ethylene-vinyl acetate copolymer, ethylene-acrylic acid copolymer ionomer, ethylene glycol, ethylene glycol / propylene glycol copolymer, ethylene glycol monoethyl Ether, ethylene glycol monobutyl ether, alkylethylmethanol (meth) acrylamide such as ethoxymethylacrylamide, Sustin, elastin degrading peptide, erythritol, octyl acrylate, octenyl succinate corn starch aluminum, curdlan, casein, casein degrading peptide, cationic polymer, cationized oligosaccharide, cationized dextran, gypsophila extract, gums, chamomile extract, carrageenan, carrageenan gum , Galactan, galactitol, galactose, galactomannan, karaya gum, carboxyvinyl polymer, carboxymethylcellulose and its sodium salt, carboxymethyl starch, caroline sulfate, licorice extract, xanthan gum, xylitol, xylose, chitin, chitin / chitosan polymer , Chitosan, cara gum, guar gum, guar hydroxypropyltrimonium chloride, etc. Thionated polysaccharide, Queensseed, glycogen, glycine-binding peptide, glucose, glucomannan, monomer having carboxyl group including crotonic acid, aluminum magnesium silicate complex, sodium magnesium silicate complex, keratin degrading peptide, keratosulfuric acid Complex, gellan gum, sesame lignan glycoside, wheat starch, rice starch, collagen, collagenolytic peptide, conchiolin degrading peptide, chondroitin sulfate, chondroitin sulfate sodium, chondroitin sulfate, comfrey extract, saxino glucan, xanthan gum, di-n -Monomers having amide groups including butylamine, diacetone acrylamide, dialkyldimethylammonium cellulose sulfate, dialkyl phosphate metal salt complex, diethyl Alkyl (meth) acrylamides such as acryl, diethylene glycol, diethylene glycol dibutyl ether, diethylene glycol monoethyl ether, diethylene glycol monomethyl ether, gellan gum, diglycerin complex, cyclodextrin, cystine complex, cysteine complex, dipropylene glycol, dibenzylidene sorbitol, Monopentaerythritol, dimethylacrylamide, monomers having amino groups including dimethylaminoacrylate, dimethyldioctadecylammonium montmorillonite clay complex, dimethylbenzyldodecylammonium montmorillonite clay complex, sucrose stearate, sucrose palmitate, sucrose Fatty acid ester, silicone elastomer Ester, silicone polymer, silicone oil, silylated peptide, silk extract, silk proteolytic peptide, white jellyfish polysaccharide, white jellyfish extract, styrene, styrene-isoprene-styrene block copolymer (SIS), styrene-ethylene / butylene-styrene block Copolymer (SEBS), styrene-ethylene / propylene-styrene block copolymer (SEPS), styrene-butadiene acrylic acid copolymer ionomer, styrene-butylene-styrene block copolymer (SBS), styrene-methacrylic acid copolymer ionomer, styrene Isoprene / styrene block copolymer, styrene-isoprene-butylene block copolymer, styrene-isoprene copolymer, styrene-butadiene copolymer, steel Copolymer, styrenic resin, stearyl acrylate, stearyl methacrylate, glycosphingolipid, sulfonated ethylene-propylene-diene copolymer ionomer, sulfonated styrene-2-acrylamido-2-methylpropane sulfate ionomer, sulfonated polystyrene ionomer, Threonine complex, gelatin, ceramide, serine complex, cellulose, sodium cellulose sulfate, sorbitol, taurine, tamarind, tara gum, tuberose polysaccharide, tyrosine complex, deoxyribose, dextran, dextrin, dextrin 2-ethylhexanoic acid palmitate , Dextrin stearate, dextrin palmitate, dextrin fatty acid ester, dextrin fatty acid Ester complex, decyl acrylate, decyl methacrylate, dermatan sulfate, telechelic polybutadiene acrylate ionomer, starch, corn starch, tragacanth gum, triethylene glycol, tryptophan complex, trimethylglycine complex, trimethylolpropane, threitol, threose, trehalose , Trolley, Nylon, Nylon resin, Nitrocellulose, Hydroxyapatite polymer, Hydroxypropyl (meth) acrylate, Hamelis extract, Varienamine complex, Validatol complex, Validamamine complex, Valine complex, Palmitoyl oligopeptide, Palmitoyl Tetrapeptide, palmitoylpentapeptide, potato starch, panthenol, hyaluronic acid, hya Sodium ronate, histidine complex, hydroxyalkylated cyclodextrin, hydroxyethylcellulose, hydroxyceramide, hydroxypropylcellulose, hydroxypropylcellulose or salts thereof, hydroxyproline, hydroxymethyl and hydroxypropylcellulose, vinylpidodon-vinyl alcohol copolymer, vinyl Pyrrolidone, vinylpyrrolidone / dialkylaminoalkyl methacrylate copolymer, hypotaurine, farseleran, phenylalanine complex, fucoidan, fucose, butadiene complex, butyl acrylate, butyl methacrylate, butylene-acrylic acid copolymer ionomer, fluorine ionomer, fluorine Polymers, butoxymethylacrylamide, fructooligosaccharide fatty acid ester, fructose Toose, pullulan, propylene, propylene-α-olefin copolymer, propylene-acrylic acid copolymer ionomer, propylene-methacrylic acid copolymer ionomer, propylene glycol, hexyl acrylate, hexylene glycol, pectin, pectic acid, hectorite , Betaine, loofah water extract, heparin, peptide, benzylidene derivative, pentaerythritol, pentylene glycol, bentonite complex, phosphorylcholine, poly-β-hydroxybutyric acid (PHB), poly-β-hydroxybutyric acid (PHB), etc. (Β-hydroxyalkanoate), poly-ε-caprolactone (PCL), poly-ω-hydroxyalkanoate such as poly-ε-caprolactone (PCL), poly (α-hydroxy acid) polymer, poly (β Hydroxyalkanoate) polymer, poly (ω-hydroxyalkanoate), poly (vinyltrimethylammonium salt) ionomer, poly (vinylpyridium salt) ionomer, poly (vinylbenzylphosphonium salt) ionomer, poly (meth) acrylic acid Ester, polyacrylamide, polyacrylic alkyl ester emulsion, polyacrylic acid, polyacrylic acid-2-ethylhexyl, polyacrylic acid-2-ethylhexyl, N-vinyl-2-pyrrolidone, dimethacrylic acid-1,6-hexane glycol Polymers, poly (acrylic acid-2-ethylhexyl / vinyl acetate / acrylic acid copolymer), poly (acrylic acid-2-ethylhexyl / vinyl acetate copolymer), polyacrylic acid / octyl acrylate copolymer, polyacrylic Acid acrylate emulsion, polyacrylate ester copolymer such as polyethyl acrylate, hydroxyethyl acrylate, polybutyl acrylate, polymethyl acrylate, polyamide, polyamide polymer, polyamino acid polymer, polyalkylene alkano Ate, polyisobutylene, polyisoprene, polyurethane, polyurethane ionomer, polyurethane elastomer, polyurethane copolymer, polyester, polyester polymer, polyethylene, polyethylene-polyamide graft copolymer, polyethyleneimine, polyethylene glycol, polyethylene succinate (PES) , Polyalkylene alkanoates such as polyethylene succinate (PES), polyethylene terephthalate, polyethylene terephthalate (PET) Copolymers of polyethylene terephthalate, polyethylene naphthalate (PEN), polyester-based resins such as a copolymer of polyethylene naphthalate, polyoxyethylene-polyoxypropylene copolymers, polyolefins, polyquaternium-10, Kachio
Cellulose, acrylic acid / diallyldimethylammonium chloride copolymer such as polyquaternium-22, acrylic acid / diallyldimethylammonium chloride / acrylamide copolymer such as polyquaternium-39, and acrylic acid / methyl acrylate such as polyquaternium-47 Methacrylamidopropyltrimethylammonium chloride copolymer, polyquaternium-51,2-methacryloyloxyethyl phosphorylcholine polymer, polyquaternium-7, diallyldimethylammonium chloride / acrylamide copolymer, polyglycolic acid (PGA), polyglycine, polyglycerin , Polyglucuronic acid, polygluconic acid, polyglutamic acid, polydioxanone polymer, polytetrafluoroethylene, polytetrafluoroethylene Polymers, polyvinyl alcohol, polyvinyl alcohol (PVA), polyvinyl ether, polyvinyl pyridone (PVP), polyvinyl pyrrolidone, polyvinyl methyl ether, polybutadiene, polybutylene succinate (PBS), polybutylene terephthalate (PBT), polybutylene Copolymer of terephthalate, polypropylene, polypropylene, polypropylene-polyamide graft copolymer, polypropylene glycol, polypentamer ionomer, poly-2-ethylhexyl methacrylate, polyvinylidene chloride, polyvinyl chloride, polynucleic acid polymer, polyacetic acid Vinyl resin emulsion, polyvinyl acetate part saponified product, poly sugar chain, poly (α-hydroxy acid) such as polylactic acid (PLA), polylactic acid (PLLA), multi-toe , Maltose, maltosylated cyclodextrin, maleic acid monoalkyl ester such as maleic acid, butyl maleate, maleic acid copolymer, mannan, mannitol, mannose, dextrin myristic acid, mucoitin sulfate, mucopolysaccharide, methacrylic acid alkyl ester, Methacrylic acid ester copolymer, glucosylethyl methacrylate copolymer, copolymer with butyl methacrylate copolymer, etc., α-β unsaturated carboxylic acid such as methacrylic acid, methionine, methylcellulose, methyl starch, etc. Molecule, methyl hydroxypropyl cellulose, methyl hydroxypropyl starch, methyl methacrylate, methyl methacrylate-butadiene-styrene resin, merirot extract, monobenzylidene sorbitol, eucalyptus extract, Lauryl acrylate, lauryl methacrylate, lauroyl hydrolyzed silk sodium, lactitol, lactose, raffinose, laminitol, lysine, ribitol, ribose, calcium phosphate polymer, leucine, locust bean gum, fumed silica, choline chloride, hydroxypropylammonium chloride Collagen, hydroxypropyltrimonium chloride, vinyl chloride, chlorocholine methacrylate polymer, hydrolyzed keratin, hydrolyzed collagen, hydrolyzed conchiolin, hydrolyzed silk, hydrolyzed wheat protein, plasticized polyvinyl chloride, plasticized acetic acid Vinyl-vinyl chloride copolymer, nucleic acid, agar, agarum, pseudoceramide, bovine submandibular gland mucin, extremely low density polyethylene, metal soap, yeast extract, high density poly Ethylene, synthetic latex-containing polymer emulsion, aliphatic polyester water-absorbing resin, aliphatic ionene, wheat proteolytic peptide, cellulose acetate, vinyl acetate, vinyl acetate-ethylene copolymer resin, hydrogenated polypentamer ionomer, Hydrogenated styrene-isopropylene-block copolymer, water dispersible polyester, linear low density polyethylene, polyhydric alcohol, placenta extract, soybean proteolytic peptide, medium density polyethylene, ultrafine silicic acid anhydride, low density polyethylene, Natural rubber, natural rubber latex, natural moisturizing factor complex, naturally derived polysaccharide, sugar alcohol, sugar ceramide, sodium lactate, lactic acid bacteria culture solution, whey, clay mineral complex, aromatic ionene, silicic acid complex, Egg shell membrane protein, salmon gum, and their Na, Ca, K, Al, Mg, Zn Salt.
Group B: Oil
(Aminoethylaminopropylmethicone / dimethicone) copolymer, (isostearic acid / sebacic acid) ditrimethylolpropane, (hydroxystearic acid / stearic acid / rosinic acid) dipentaerythrityl, (hexyldecanoic acid / sebacic acid) diglyceryl oligoester, 12-hydroxy Stearic acid, cholesteryl 12-hydroxystearate, cetyl 2-ethylhexanoate, triglyceride 2-ethylhexanoate, N-lauroyl-L-glutamate di (cholesteryl / octyldodecyl), N-lauroyl-L-glutamate di (cholesteryl / Behenyl / octyldodecyl), N-lauroyl-L-glutamate di (phytosteryl / octyldodecyl), N-lauroyl-L-glutamate di (phytosteryl / behe) Octyldodecyl), acyl sarcosine alkyl esters such as N-lauroyl sarcosine isopropyl, α-olefin oligomer, almond extract oil, almond oil, iris extract oil, ashitaba extract oil, isopropyl adipate, diisobutyl adipate, diisopropyl adipate, Asnalo extract oil, asparagus extract oil, avocado extract oil, avocado oil, avocado oil fatty acid ethyl, amacha extract oil, flaxseed oil, aminopropyl dimethicone, amino acid modified silicone, amino modified and polyether modified silicone, amodimethicone, alkyl ether modified Silicone, alkyl-modified silicone, alkyl-modified and polyether-modified silicone, Altea extract oil, Arnica extract oil, Aloe extract oil, apricot kernel extract oil, apricot extract oil, ante Isoshenicosanoic acid, isostearyl cholesteryl ester, isostearic acid, isopropyl isostearate, octyldodecyl isostearate, cholesteryl isostearate, phytosteryl isostearate, isostearic acid hydrogenated castor oil, isotridecyl isononanoate, isononyl isononanoate, octyl isononanoate, isohexadecanoic acid, Ginkgo biloba extract, Inchkou extract oil, Fennel extract oil, Oolong tea extract oil, Turmeric extract oil, Horse oil, Walnut extract oil, Undecylenic acid, Eicosapentaenoic acid, Ages extract oil, Echinacea leaf extract oil, Ethylene / propylene copolymer, erucic acid , Octyldodecyl erucate, Enmeso extract oil, Ogon extract oil, Oat extract oil, Oren extract oil, Barley extract oil, Octamethy Trisiloxane, cetyl octoate, hexyldecyl octoate, ozokerite, ginseng extract oil, hypericum extract oil, licorice extract oil, onionis extract oil, Dutch mustard extract oil, olive oil, olive-derived squalane, oleic acid, ethyl oleate, oleic acid Animal waxes such as octyldodecyl, oleyl oleate, cholesteryl oleate, and orange luffy oil; liquid lanolin, orange extract oil, orange oil, cocoa butter, cacao oil, oyster extract oil, oyster leaf extract oil, cation-modified silicone Cation-modified and polyether-modified silicone, cuckoo extract oil, chamomile extract oil, oat extract oil, carcade extract oil, carnauba wax, carnauba wax, carnauba wax, carboxylic acid modified silicone, carrot extract , Kawara mugwort extract oil, licorice extract oil, kiwi extract oil, kiou extract oil, jellyfish extract oil, kina extract oil, candelilla wax, candelilla wax, cucumber extract oil, giraffe leaf extract oil, guanosine, guava extract oil, citric acid Triethyl, cucumber nut oil, cucumber extract oil, gardenia extract oil, Kumaza extract oil, Clara extract oil, chestnut extract oil, walnut extract oil, grape seed oil, grapefruit extract oil, clematis extract oil, chlorella extract oil, mulberry extract oil, gentian Extracted oil, Genno shochu extract oil, Koboku extract oil, Coenzyme A, Coffee extract oil, Cholic acid, Cowberry extract oil, Dioctyl succinate, Burdock extract oil, Sesame oil, Rice fermented extract oil, Rice bran oil, Rice extract oil, Rice fermented extract Oil, rice germ oil, collagen, cholesterol, co Lesterol oleate, Comfrey extract oil, Psycho extract oil, Saisin extract oil, Saitai extract, Sasa extract oil, Safflower oil, Saffron extract oil, Sapogenin, Saponins, Salmon extract oil, Salvia extract oil, Hawthorn extract oil, Sansha extract oil, salamander extract oil, shea fat, glyceryl diisostearate, diglyceryl diisostearate, dimerisolinoleyl diisostearate, shiitake extract oil, dio extract oil, 2-butyl-2-ethyl-1,3-octanoate Propanediol, Neopentyl glycol dioctanoate, Propylene glycol dioleate, Neopentyl glycol dicaprate, Cyclomethicone (cyclic dimethylsiloxane, sicon extract oil, glycol distearate (ethylene glycol distearate), perilla Oil extraction, linden extract oil, dihydrocholesterol, dihydrolanosterol, diphenyl dimethicone, dimethiconol, dimethiconol crosspolymer, dimethicone (dimethylpolysiloxane), dimethicone copolyol, hexyldecyl dimethyloctanoate, citrus extract oil, peony extract oil, jatoba extract oil , Ginger extract oil, ginger root extract oil, birch extract oil, silicone rubber, silicone resin, sugina extract oil, squalane, squalane, squalene, stearic acid, cholesteryl stearate, butyl stearate, stearoxypropyldimethylamine, stevia extract Oil, stevia fermented product, sphingophospholipid such as sphingomyelin, kizuta extract oil, hawthorn extract oil, elderberry extract oil, Achillea millet extract oil, mint extract oil, sage extract oil, mallow extract oil, diisopropyl sebacate, diethyl sebacate, dioctyl sebacate, dibutyloctyl sebacate, ceresin, ceresin wax, sencu extract, seburi extract, sucha akuhi extract Animal fats and oils such as oil and turtle oil; whale wax, diou extract oil, soybean extract oil, peanut extract oil, dimer linoleic acid (phytosteryl / isostearyl / cetyl / stearyl / behenyl), dimer linoleic acid (phytosteryl / Behenyl), dimer dilinoleate di (isostearyl / phytosteryl), dimer dilinoleate diisostearyl, dimer dilinoleate diisopropyl, dimer dilinoleate dimer dilinoleyl, dimer dilinol Acid-hardened castor oil, dimer linoleyl hydrogenated rosin condensate, dimer acid, thyme extract oil, dandelion extract oil, chigaya extract oil, clove extract oil, chimpi extract oil, camellia oil, camellia oil, tea tree oil, deca (Elca) Acid / isostearic acid / ricinoleic acid) polyglyceryl-8, decamethylcyclopentasiloxane, decamethylcyclopentasiloxane), decamethyltetrasiloxane, polyglyceryl tetraisostearate, pentaerythrityl tetraoctanoate, red pepper extract oil, red pepper extract oil , Toki extract oil, tonin extract oil, spruce extract oil, spruce oil, corn oil, dokudami extract oil, docosahexaenoic acid, dodecamethylcyclohexasiloxane, tomato extract oil, tri (caprylic acid / capric acid) glyceryl, tri (cap) (Luic acid / capric acid / myristic acid / stearic acid) glyceryl, glyceryl triisostearate, trimethylolpropane triisostearate, ditrimethylolpropane triethylhexanoate, pentaerythrityl triethylhexanoate, glyceryl trioctanoate, trimethylolpropane trioctanoate, Glyceryl trioleate, rapeseed oil, carrot extract oil, garlic extract oil, octyldodecyl neodecanoate, isostearyl neopentanoate, isodecyl neopentanoate, isotridecyl neopentanoate, polyglyceryl nonaisostearate, cholesteryl nonanoate, Novara extract oil, permanent Fluorinated oils such as oil, birch extract oil, perfluorooctane, perfluorodecane, perfluoropolyether, Kernel oil, palm oil, hibiscus extract oil, bacmond extract oil, lotus extract oil, parsley extract oil, mint oil, hamamelis extract oil, paraffin wax, parietaria extract oil, cetyl parimate, palmitic acid, isopropyl palmitate, octyl palmitate , Palmitate octyldodecyl, palmitate diethanolamide (partamide DEA), palmitate monoethanolamide (partamide MEA), palmitooleic acid, chickpea extract oil, pycnogenol, bisabolol, hydroxyalkyl dimer linoleyl ether, hydroxy lanolin, hinoki Extract oil, Bifidobacterium extract oil, castor oil, sunflower oil, loquat extract oil, Fischer-Tropsch wax, phytosterol, phenyl dimethicone, phenyl trimethicone, Fukidanpopo extract oil, Fukinotou extract oil, Bukuryo extract oil, Butcher bloom extract oil, fluorinated silicone, grape seed extract oil, grape extract oil, propolis, hazelnut oil, loofah extract oil, petrolatum, safflower extract oil, peppermint extract oil, peptide Modified silicone, behenic acid, behenic acid, glyceryl behenate, glyceryl behenate, phosphatidylinositol, phosphatidylethanolamine, phosphatidylglycerol, phosphatidylcholine, phosphatidylserine, phosphatidic acid, body extract oil, button extract oil, hop extract oil, jojoba oil, polyisobutene , Polyethylene wax, polyoxyethylene lanolin, polyglycerin-modified silicone, polysiloxane-oxyalkylene copolymer, polybutene, Squid extract oil, microcrystalline wax, macadamia nut oil, macadamia nut oil, macadamia nut oil fatty acid cholesteryl, macadamia nut oil fatty acid phytosteryl, pine extract oil, maronier extract oil, citrus extract oil, beeswax, beeswax, mineral oil, myristic acid, isooctyl myristate , Isotridecyl myristate, isopropyl myristate, octadecyl myristate, octyldodecanol myristate, octyldodecyl myristate, hexyldecyl myristate, myristyl myristate, mink oil, mucrodi extract oil, methylcyclopolysiloxane, methylphenylpolysiloxane, etc. Cyclic silicone oils such as methylphenyl silicone oil and methylpolycyclosiloxane; polyether-modified silicone Oil, methylpolysiloxane, meadow foam oil, melissa extract oil, owl oil, mozuku extract oil, monoalcohol carboxylic acid ester, monoisostearic acid hydrogenated castor oil, oxyacid ester, peach extract oil, montan wax, cornflower extract Oil, coconut oil, coconut oil fatty acid diethanolamide (cocamide DEA), coconut oil fatty acid methylethanolamide (cocamide methyl MEA), coconut oil fatty acid monoethanolamide (cocamide MEA), eucalyptus extract oil, yukinoshita extract oil, yuzu extract oil, lily Extracted oil, Yokuinin extracted oil, Artemisia extract oil, Rice wax, Lauric acid, Lauric acid diethanolamide (Lauramid DEA), Lauric acid hexyl, Lauric acid monoisopropanolamide (Lauramid MIPA), Lauric acid monoethanol Phospholipids such as luamide (lauramide MEA), lanosterol, lanolin, lanolin fatty acid, lanolin fatty acid isopropyl, lanolin fatty acid octyldodecyl, lavender extract oil, octyldodecyl ricinoleate, lysolecithin; hydrogenated soybean phospholipid, linoleic acid, linoleic acid, Diisostearyl malate, apple extract oil, phosphate-modified silicone, phospholipid / cholesterol complex, phospholipid / phytosterol complex, rooibos tea extract oil, litchi extract oil, lettuce extract oil, lemon extract oil, forsythia extract oil, Astragalus extract oil, rosehip oil, rosemary extract oil, rose extract oil, Roman chamomile extract oil, royal jelly extract oil, rosin triglyceride (ester gum), petrolatum, bitumen extract oil, hydrolyzed elastin, water Wheat powder, hydrolyzed silk, dried sea water, seaweed extract, reduced lanolin, adsorbed refined lanolin, beef tallow, metal soaps, light liquid isoparaffin, whale wax, evening primrose oil, hardened oil, hard lanolin fatty acid, hard lanolin fatty acid cholesteryl , Black tea extract oil, yeast extract oil, highly polymerized dimethyl
Dimethyl silicone oils such as chicon (highly polymerized dimethylpolysiloxane) and highly polymerized methylpolysiloxane; octamethylcyclotetrasiloxane, black rice extract oil, fatty acid-modified silicone, fat-soluble brown sugar extract, fat-soluble black vinegar extract, heavy Lanolins such as liquid isoparaffin, wheat germ oil, acetic acid (cetyl lanolyl) ester; lecithin, cholesteryl acetate, lanolin acetate, lanolin acetate alcohol, liquid lanolin acetate, hydrogenated dimer acid, hydrogenated castor oil, hydrogenated jojoba oil, Hydrogenated coconut oil, hydrogenated rosin pentaerythrityl, hydrogenated egg yolk phospholipid, hydrogenated polyisobutene, hydrogenated rosin triglyceride (hydrogenated ester gum), Nishiheaya extract oil, soybean oil, lichen extract oil, tea extract oil, Tea oil, clove oil, long chain α-hydroxy fatty acid cholesteryl, long Branched fatty acid, long chain branched fatty acid cholesteryl, strawberry tea extract oil, sugar-modified silicone, soft lanolin fatty acid cholesteryl, cetyl lactate, milk fat, natto extract oil, horse fat, white fungus extract oil, partially hydrogenated soybean phospholipid, partially hydrogenated egg yolk phosphorus Lipid, rice germ oil, honey, beeswax, cottonseed oil, tree wax, beeswax, oil-soluble licorice extract oil, peanut oil, egg yolk oil, eggshell membrane extract oil, liquid paraffin, liquid paraffin (mineral oil), sulfate-modified silicone, Green tea extract oil.
Group C: Surfactant
2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, N-acyl amino acid ester, N-acyl amino acid salt, N-dimethylamino acid betaine, PPG-9 diglyceryl, α-oleic acid pyroglutamate glycerin Α-olefin sulfonic acid sodium salt, α-sulfo fatty acid methyl ester salt, acrylic acid / methacrylic acid alkyl copolymer, acyl isethionate, sodium acyl glutamate, acyl lactate, aminopropyl dimethicone and amodimethicone, amino-modified and poly Ether-modified silicone, alkanesulfonate, alkylamine salt, alkylaryl ether phosphate, alkylisoquinolinium salt, alkyletheraminemonium salt, alkylethoxydimethylamine oxide , Alkyl glycidyl ether sulfonate, alkyl dimethylaminoethanol phosphate, alkyl dimethylamino ethanol sulfate, alkyl dimethyl taurine, alkyl sulfoacetate, alkyl trialkylene glycol ammonium salt, alkyl naphthalene sulfonate, alkyl benzene sulfonate, Alkylbenzene polyoxyethylene sulfate, alkyl polyglycoside, sodium alginate, isostearyl glyceryl ether, glyceryl isostearate, polyglyceryl isostearate, isosteares (polyoxyethylene isostearyl ether), imidazolinium salt, undecylenic acid trehalose, ethyl sulfate Lanolin fatty acid aminopropylethyldimethylammonium, ethyl sulfate long Branched fatty acid (12-31) aminopropylethyldimethylammonium, octyldedes (polyoxyethylene octyldodecyl ether), glyceryl oleate, polyglyceryl oleate-2, sodium caseinate, cation-modified silicone, cation-modified and polyether-modified silicone, caprylyl Glucoside, Carboxylic acid modified silicone, Chimyl alcohol, Cocamidopropyl betaine, Cocamine oxide, Sodium cocoamphoacetate, Cocoyl alanine triethanolamine, Triethanolamine cocoyl glutamate, Sodium cocoyl glutamate, Potassium cocoyl methyl taurate, Sodium cocoyl methyl taurate, Surfactin, saponin, dialkyl morphonium salt, polyglyceride diisostearate -2 (diglyceryl diisostearate), polyglyceryl-6 dioleate, dicocodimonium chloride, distearyldimonium chloride, polyglyceryl distearate-6, dimethicone copolyol, sucrose fatty acid ester, sodium dilaureth phosphate, stearamide ethyl diethylamine , Stearamidepropyldimethylamine, stearamine oxide, stearyltrimonium bromide, glyceryl stearate, sodium stearate, polyglyceryl-2 stearate, steartrimonium chloride, steareth (polyoxyethylene stearyl ether) s, stearoyl glutamate sodium, stear Roxypropyldimethylamine, sphingomyelin, dioctyl sodium sulfosuccinate, sulfosucci Disodium lauryl succinate, disodium laureth sulfosuccinate, glyceryl sesquioleate, sodium cetyl sulfate, ceteth (polyoxyethylene cetyl ether) s, cetrimonium chloride, seraquil alcohol, sophorolipid, sorbitan sesquioleate, sorbitan trioleate, Sorbitan monoisostearate, sorbitan monooleate, sorbitan monostearate, sorbitan monopalmitate, sorbitan monolaurate, sorbitan fatty acid ester, sorbitol partial fatty acid ester, polyglyceryl-10 decaisostearate, polyglyceryl-10 decaoleate, decastearate Polyglyceryl-10, tetra-2-ethylhexyl diglycerol sorbitan, polytetraisostearate Lyseryl-2, tetradecylbenzenesulfonic acid triethanolamine, sodium tetradecylbenzenesulfonate, tetrapolyoxyethylene / tetrapolyoxypropylene-ethylenediamine condensates, starch derivatives, tragacanth gum, polyglyceryl-2 triisostearate, trioleic acid Polyglyceryl-2, polyglyceryl-2 tristearate, sodium trilaureth phosphate, batyl alcohol, potassium palmitate, glyceryl palmitate, diethanolamide palmitate (partamide DEA), triethanolamine palmitate, monoethanolamide palmitate (partamide) MEA), palmitoyl aspartate ditriethanolamine, behenamine oxide, behenes (polyoxyethylene) (Henyl ether), behentrimonium chloride, benzalkonium salt, benzethonium salt, diglycerolsorbitan penta-2-ethylhexylate, pentaerythritol partial fatty acid ester, phosphatidylinositol, phosphatidylethanolamine, phosphatidylglycerol, phosphatidylcholine, phosphatidylserine, phosphatidic acid , Polyamine fatty acid derivative, polyol fatty acid ester, polyoxyethylene / propylene glycol fatty acid ester, polyoxyethylene / polyoxypropylene 2-decyltetradecyl ether, polyoxyethylene / polyoxypropylene alkyl ether, polyoxyethylene / polyoxypropylene glycol , Polyoxyethylene / polyoxypropylene glycerin Ether, polyoxyethylene / polyoxypropylene cetyl ether, polyoxyethylene / polyoxypropylene monobutyl ether, polyoxyethylene / polyoxypropylene hydrogenated lanolin, polyoxyethylene alkylamine, polyoxyethylenealkylamine and salts or quaternary thereof Salt, polyoxyethylene alkyl ether, polyoxyethylene alkyl ether phosphate, polyoxyethylene alkyl ether fatty acid ester, polyoxyethylene alkyl ether sulfate, polyoxyethylene alkyl phenyl ether, polyoxyethylene alkyl phenyl ether phosphate, polyoxy Ethylene alkyl phenol ether, polyoxyethylene alkyl mercaptan, polyoxyethylene glycerin triisostearate , Polyoxyethylene glycerol monoisostearate, polyoxyethylene glycerol monostearate, polyoxyethylene glycerol fatty acid ester, polyoxyethylene cholestanol, polyoxyethylene cholesterol, polyoxyethylene dioleate, polyoxyethylene distearate, Polyoxyethylene sorbitan tetraoleate, polyoxyethylene sorbitan monooleate, polyoxyethylene sorbitan monooleate, polyoxyethylene sorbitan monostearate, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene sorbitol pentaoleate, polyoxyethylene sorbitol Beeswax, polyoxyethylene sorbitol monooleate, polyoxyethylene sorbitol mono Stearate, polyoxyethylene sorbitol monolaurate, polyoxyethylene sorbitol fatty acid ester, polyoxyethylene castor oil, polyoxyethylene phytosterol, polyoxyethylene methyl glucoside fatty acid ester, polyoxyethylene monooleate, polyoxyethylene monooleate , Sodium polyoxyethylene lauryl phosphate, polyoxyethylene lanolin, polyoxyethylenated sterol, polyoxyethylenated lanolin, polyoxyethylene reduced lanolin, polyoxyethylene hydrogenated castor oil, polyoxyethylene hydrogenated castor oil, polyoxyethylene hardened Castor oil triisostearate, polyoxyethylene hydrogenated castor oil maleic acid, polyoxyethylene hydrogenated castor oil monoisostearate, Reoxyethylene hydrogenated castor oil monopyroglutamic acid monoisostearic acid diester, polyoxyethylene fatty amine sulfate, polyoxyethylene fatty acid amide, polyoxyethylene fatty acid ester, polyglycerin-modified silicone, polysiloxane-oxyalkylene copolymer, polyethylene Glycol diisostearate, polyvinyl alcohol, maltitol ether, maltitol partial fatty acid ester, potassium myristic acid, glyceryl myristate, sodium myristoyl glutamate, sodium myristoyl methyl taurate, methyl glucoside fatty acid ester, glyceryl monoerucate, sodium monoolesphosphate, mono Ethylene glycol stearate, ethylene glycol monostearate, glyceryl monostearate Phosphorous, glyceryl monostearate, propylene glycol monostearate, propylene glycol monostearate, monolauroyl monoethanolamide sodium polyoxyethylene sulfosuccinate, mono cottonseed oil fatty acid glycerin, coconut oil fatty acid glyceryl, coconut oil fatty acid diethanolamide (cocamide) DEA), coconut oil fatty acid methylethanolamide (cocamide methyl MEA), coconut oil fatty acid monoethanolamide (cocamide MEA), lauramidopropylbetaine, lauramine oxide, lauryldimethylaminoacetic acid betaine, lauryltrimonium chloride and other alkyltrimethylammonium chlorides , Lauryl betaine (lauryl dimethylaminoacetic acid betaine), lauryl polypropylene glycol sulfosoh Sodium laurate, potassium lauryl phosphate, ammonium lauryl sulfate, lauryl sulfate ester salt, lauryl sulfate triethanolamine, sodium lauryl sulfate, potassium laurate, lauric acid diethanolamide (lauramide DEA), lauric acid monoisopropanolamide (lauramide MIPA), lauric acid Acid monoethanolamide (lauramide MEA), laureth (polyoxyethylene lauryl ether), sodium laureth phosphate, sodium laureth acetate, triethanolamine laureth sulfate, sodium laureth sulfate, sodium lauroamphoacetate, sodium lauroyl glutamate, sodium methylalanine lauroyl glutamate , Lauroyl sarcosine triethanolamine, lauroyl sarcosine sodium , Amphoteric surfactants such as sodium lauroylmethylalanine, sodium lauroylmethyltaurine, sodium lauroylmonoethanolamide succinate, lanolin alcohol, lysolecithin, phosphate-modified silicone, lecithin, distearyldimethylammonium chloride, stearyldimethylbenzylammonium chloride, Pyridinium salts such as stearyltrimethylammonium chloride, cetylpyridinium chloride, benzalkonium chloride, benzethonium chloride, alkyldiaminoethylglycine hydrochloride, reduced lanolin, hydrogenated coconut oil fatty acid sodium glycerin sulfate, fatty acid amide ether phosphate, fatty acid amidoguanidinium Salt, fatty acid alkanolamide ether carboxylate, fatty acid alkanolamide sulfate, fatty acid alkylolamide Lipophilic glyceryl monooleate, lecithin hydroxide, hydrogenated soybean phospholipid, hydrogenated egg yolk phospholipid, polyhydric alcohol alkyl ether, sugar-modified silicone, partially hydrogenated soybean phospholipid, partially hydrogenated egg yolk Phospholipid, sulfuric acid modified silicone.
Group D: Antioxidant
BHA, BHT, β-carotene, γ-amino-β-hydroxybutyric acid, astaxanthin, acetoxyhydroxybenzoic acid, ellagic acid, erythorbic acid and its derivatives, chamomile extract, guaiac oil, kojic acid, diacetoxybenzoic acid, diisopropylamine dichloroacetate , Cysteamine, cysteine, cysteine hydrochloride, dibutylhydroxytoluene, Sakuhak extract, thioglycolic acid, thioglycolic acid, thioglycerol, thiotaurine, thiourea, sodium thiosulfate, thiosulfate, tocotrienol, tocopheryl acetate, tocopheryl dimethyl Glycine, tocopheryl nicotinate, tocopheryl linoleate, tocopheryl phosphate Na, tocopherol, tocopherol (vitamin E), nordihydroguaiaretic acid, hydroxy , Hydroquinone glucoside, hydroquinone benzyl ether, retinol palmitate, hypotaurine, butylhydroxyanisole, butylhydroxyanisole, butylhydroxytoluene, butylresorcinol, metabisulfite, methylenebis (4-methyl-6-tert-butyl) phenol, Yukinosita extract, resorcinol, retinoic acid, sodium sulfite, bisulfite such as sodium sulfite, sodium bisulfite, hydrogen peroxide, percarbonate, ammonium persulfate, sodium bromate, tocopherol acetate, retinol acetate, placental extract, rice bran Extracts, gallic acid, propyl gallate, propyl gallate, gallic acid derivatives.
Group E: UV absorption shielding agent
1,1-dicarboxy (2,2′-dimethylpropyl) -4,4-diphenylbutadiene, 1,1 ′-(1,4-piperazinediyl) bis [1- [2- [4- (diethylamino)- 2-hydroxybenzoyl] phenyl] -methanone, n-hexyl 2- (4-diethylamino-2-hydroxybenzoyl) benzoate, p-aminobenzoic acid (PABA) compound, dimer derived from α-alkylstyrene, β-diphenylacrylate compound , Alumina, anthranyl compound, imidazoline compound, ethylhexyl triazone, octocrylene, camphor benzilyl methosulfate, 4-methylbenzylidene camphor, camphor compound, cinnamic acid compound, ethylhexyl salicylate, salicylic acid, 4,4-diarylbutadiene, butylmethoxy Dibenzoylmethane, diethylhexylbutamide triazone , Dineopentyl 4'-methoxybenzalmalonate, dibenzoylmethane compound, silane, silica, silicone, terephthalylidene dicamphorsulfonic acid, triazine compound, tris- (di-phenyl) -triazine, 2,4,6-tris (Dineopentyl 4′-aminobenzalmalonate) -s-triazine, 2,4,6-tris (diisobutyl4′-aminobenzalmalonate) -s-triazine, 2,4,6-tris- (ter- Phenyl) -triazine, 2,4,6-tris- (di-phenyl) -triazine, drometrizole trisiloxane, bis-ethylhexyloxyphenol methoxyphenyl triazine, bis-benzoazolyl compound, bis [5-1 (dimethylpropyl) Benzoxazol-2-yl- (4-phenyl) imino] -6- (2-ethylhexyl) imino-1,5-triazine, phenyldibenzoi Midazol tetrasulfonate disodium, 2,4-bis- (n-butyl 4'-aminobenzalmalonate) -6 [(3- {1,3,3,3-tetramethyl-1-[(trimethylsilyl Oxy) -disiloxanyl] propyl} amino) -s-triazine, 2,4-bis [5-1 (dimethylpropyl) benzoxazol-2-yl- (4-phenyl) imino] -6- (2-ethylhexyl) imino -1,3,5-triazine, phenylbenzimidazole sulfonic acid, benzalmalonate compound, benzimidazole compound, benzoxazole compound, benzotriazole compound, benzophenone-3, benzophenone-4, benzophenone-5, benzophenone compound, homosalate, Polysilicone-15, methylbenzylidene camphor, methylenebis-benzotriazolyltetramethylbutylphenol, methylene (Hydroxyphenylbenzotriazole) compound, ethylhexyl methoxycinnamate, zirconium oxide, cerium oxide, titanium oxide (amorphous or rutile and / or anatase crystalline), zinc oxide, iron oxide, shielding polymer and Shielding silicone, aluminum hydroxide.
Group F: Bacterial growth inhibitor
1,2-hexanediol, 1,2-pentanediol, EDTA, EDTA2Na, EDTA3Na, EDTA4Na, HEDTA3Na, amphotericin B, alanine, isopropylphenol, imidazolinium urea, undecylenic acid, oxalamide, etidronic acid and other phosphonic acids, ethyl Paraben, ethyl alcohol, erythromycin, oxytetracycline, octanol, chlorhexidine gluconate, cresol, clotrimazole, chloramphenicol, chlorhexidine, salicylic acid, cyclopyroxolamine, siccanin, dihydroxyethylglycine, sodium oxalate, zinc pyrithione, sorbic acid , Thianthol, thymol, tetracycline, dehydroacetic acid, decanol, triclosanamide, Chlorocarbanide, tricomycin, tolnaftate, nystatin, nornaphthate, parachlorophenol, variotin, halocarban, haloprozin, hydroxyethylethylenediamine triacetate, hydroxybenzoic acid, hinokitiol, pimafucin, pyrrolnitrin, propyl alcohol, phytic acid, phenyl Ethyl alcohol, phenylphenol, sodium phenylphenol, phenyliododecinoate, phenol, phenoxyethanol, butyl paraben, butyl alcohol, propyl paraben, hexachlorophene, hexanol, heptanol, penicillin, pentamycin, pentanol, pentetate (diethylenetriamine) Pentaacetate), polyaspartic acid, polyglutamic acid, sodium polyphosphate , Sodium metaphosphate, methylisothiazolinone, methylchloroisothiazolinone, methylparaben, sodium benzoate, benzalkonium chloride, benzethonium chloride, photosensitizers, silver ions, antibacterial zeolite, isoconazole nitrate, econazole nitrate, omoconazole nitrate , Ketoconazole nitrate, sulconazole nitrate, thioconazole nitrate, miconazole nitrate, fradiomycin sulfate.
Group G: pH adjusting substance
2-amino-2-hydroxymethyl-1,3-propanediol, 2-amino-2-methyl-1,3-propanediol, acrylamide-acrylic acid copolymer, alkaline earth metal hydroxide, arginine, alginic acid , Ammonia, aqueous ammonia, isopropanolamine, citric acid, citric acid, sodium citrate, glycolic acid, succinic acid, diisopropanolamine, diethanolamine, diethylamine, dimethylamine, styrene-maleic anhydride copolymer, starch-acrylic acid Graft polymer, triisopropanolamine, triethanolamine, triethylamine, trimethylamine, fumaric acid, polyacrylic acid, polyaspartic acid, polyitaconic acid, polyethanolamine, polyglutamic acid, polyvinyl acetate -Crotonic acid copolymer, polyvinyl sulfonic acid, monoethanolamine, malic acid, trisodium phosphate, dipotassium hydrogen phosphate, disodium hydrogen phosphate, hydrochloric acid, tartaric acid, nitric acid, acetic acid, sodium acetate, vinyl acetate-( (Meth) acrylic acid copolymer, vinyl acetate-crotonic acid copolymer, potassium hydroxide, calcium hydroxide, sodium hydroxide, magnesium hydroxide, ammonium carbonate, guanidine carbonate, lactic acid, sodium lactate, sulfuric acid.

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