JP5726481B2 - Cosmetic or skin external preparation containing hydroxynicotinic acid or a derivative thereof - Google Patents

Description

  The present invention relates to a cosmetic or an external preparation for skin containing hydroxynicotinic acid or a derivative thereof.

  Nicotinic acid and nicotinic acid amide are also called niacin and are known as a kind of water-soluble vitamins. Generally, nicotinic acid is contained in vegetable foods, and nicotinic acid amide is contained in animal foods. They have long been used as pharmaceuticals for the prevention and treatment of multivitamins or pellagra. Moreover, it is utilized also for cosmetics, and it is known as an effect that nicotinic acid and its derivative have a blood circulation promotion effect, a rough skin improvement effect, etc. (patent document 1). In recent years, the whitening effect of nicotinamide is also known (Patent Document 2). However, it cannot be said that the whitening effect of conventional nicotinic acid or its derivatives is sufficient, and when these are used for whitening, it is necessary to blend them at a high concentration in order to exert the effect. On the other hand, it has been reported that cosmetics containing nicotinic acid and its derivatives may feel irritation to the skin (Patent Document 3). For this reason, the nicotinic acid derivative excellent in the whitening effect which exhibits an effect at a lower concentration has been desired.

  Hydroxynicotinic acid is known as a hair growth promoter for use in hair cosmetics (Patent Document 4), but is not known for use in skin cosmetics or skin external preparations. Further, amide derivatives and ester derivatives of hydroxynicotinic acid are not known for use in cosmetics or external preparations for skin.

JP 09-002952 A JP2007-176810A JP2003-104867A JP 03-086811 A

  Provided are a nicotinic acid derivative having a whitening effect superior to that of conventional nicotinic acid or a derivative thereof, and a cosmetic or an external preparation for skin containing the nicotinic acid derivative.

（式中、Ｒ１およびＲ２はそれぞれ独立して、水素原子、又は、水酸基で置換されていてもよい炭素数１〜２２の直鎖又は分岐鎖の炭化水素基を表す）

（式中、Ｒ３は、炭素数１〜２２の直鎖、分岐鎖又は環状の炭化水素基を表す） As a result of intensive studies to solve the above problems, the present inventors have found that hydroxynicotinic acid represented by the following general formula (1) or a salt thereof, and hydroxynicotinic acid amide represented by the following general formula (2) It has been found that the above problems can be solved by using a derivative or a hydroxynicotinic acid ester derivative represented by the following general formula (3), and the present invention has been completed.

(In the formula, R1 and R2 each independently represent a hydrogen atom or a linear or branched hydrocarbon group having 1 to 22 carbon atoms which may be substituted with a hydroxyl group)

(Wherein R3 represents a linear, branched or cyclic hydrocarbon group having 1 to 22 carbon atoms)

  The hydroxynicotinic acid or derivative thereof of the present invention has a whitening effect superior to conventional nicotinic acid derivatives, and can be preferably blended into cosmetics or skin external preparations.

  The present invention relates to a cosmetic or skin external preparation containing hydroxynicotinic acid or a derivative thereof. The hydroxynicotinic acid or a derivative thereof of the present invention specifically means hydroxynicotinic acid or a salt thereof, a hydroxynicotinic acid amide derivative, or a hydroxynicotinic acid ester derivative.

Hydroxynicotinic acid used in the present invention is a compound represented by the following general formula (1).

  The manufacturing method of the hydroxynicotinic acid used by this invention is not specifically limited, It can manufacture by a well-known manufacturing method. Specifically, 3-cyano-6-hydroxypyridine can be obtained by hydrolyzing a cyano group under acidic conditions.

  The hydroxynicotinic acid of the present invention produced as described above may be blended as it is in cosmetics or skin external preparations, or may be blended in a carboxylate state. When formulated as a salt, alkali metal salts such as sodium salt and potassium salt, alkaline earth metal salts such as calcium salt and magnesium salt, basic amino acid salts such as lysine salt and arginine salt, aluminum salt, iron salt, zinc Metal salts such as salts, copper salts and cobalt salts can be used.

（式中、Ｒ１およびＲ２はそれぞれ独立して、水素原子、又は、水酸基で置換されていてもよい炭素数１〜２２の直鎖又は分岐鎖の炭化水素基を表す） The hydroxynicotinic acid amide derivative used in the present invention is a compound represented by the following general formula (2) in which the carboxyl group of hydroxynicotinic acid is amidated.

(In the formula, R1 and R2 each independently represent a hydrogen atom or a linear or branched hydrocarbon group having 1 to 22 carbon atoms which may be substituted with a hydroxyl group)

  Of the hydrogen atoms constituting R1 and R2 or a linear or branched hydrocarbon group having 1 to 22 carbon atoms which may be substituted with a hydroxyl group, 1 carbon atom which may be substituted with a hydroxyl group Specific examples of the linear or branched hydrocarbon group of ˜22 include methyl group, ethyl group, propyl group, isopropyl group, n-butyl group, isobutyl group, t-butyl group, n-pentyl group, Isopentyl group, neopentyl group, n-hexyl group, n-heptyl group, n-octyl group, n-nonyl group, n-decyl group, n-undecyl group, n-dodecyl group, n-tridecyl group, n-tetradecyl group N-pentadecyl group, n-hexadecyl group, n-heptadecyl group, n-octadecyl group, n-nonadecyl group, n-icosyl group, n-docosyl group, 2-ethylhexyl group, 2-butyloxy Til, 2-butyldecyl, 2-hexyloctyl, 2-hexyldecyl, 2-octyldecyl, 2-hexyldecyl, 2-octyldecyl, 2-hydroxyethyl, 2-hydroxypropyl, 3-hydroxypropyl group, 2-hydroxybutyl group, 4-hydroxybutyl group and the like can be mentioned. Of these R1 and R2, a hydrogen atom, a methyl group, an ethyl group, a propyl group, and a butyl group are preferable in terms of exerting a whitening effect. Moreover, it is more preferable that either R1 or R2 is a hydrogen atom, and it is most preferable that both R1 and R2 are hydrogen atoms.

  The manufacturing method of the hydroxynicotinic acid amide derivative of this invention is not specifically limited, It can manufacture by a well-known manufacturing method. Specifically, it can be synthesized by amidating hydroxynicotinic acid and various amines using a dehydration condensing agent or the like. If both R1 and R2 are hydroxynicotinic acid amides that are hydrogen atoms, 3-cyano-6-hydroxypyridine can also be synthesized by hydrolyzing the cyano group under alkaline conditions.

（式中、Ｒ３は、炭素数１〜２２の直鎖、分岐鎖又は環状の炭化水素基を表す） The hydroxynicotinic acid ester derivative used in the present invention is a compound represented by the following general formula (3) in which the carboxyl group of hydroxynicotinic acid is esterified.

(Wherein R3 represents a linear, branched or cyclic hydrocarbon group having 1 to 22 carbon atoms)

  Specific examples of the straight-chain, branched-chain or cyclic hydrocarbon group having 1 to 22 carbon atoms constituting the R3 include a methyl group, an ethyl group, a propyl group, an isopropyl group, an n-butyl group, and an isobutyl group. , T-butyl group, n-pentyl group, isopentyl group, neopentyl group, n-hexyl group, n-heptyl group, n-octyl group, n-nonyl group, n-decyl group, n-undecyl group, n-dodecyl group Group, n-tridecyl group, n-tetradecyl group, n-pentadecyl group, n-hexadecyl group, n-heptadecyl group, n-octadecyl group, n-nonadecyl group, n-icosyl group, n-docosyl group, 2-ethylhexyl Group, 2-butyloctyl group, 2-butyldecyl group, 2-hexyloctyl group, 2-hexyldecyl group, 2-octyldecyl group, 2-hexyldecyl group, 2- Kuchirudodeshiru group, and the like. Among these, an ethyl group, a propyl group, an isopropyl group, an n-butyl group, an isobutyl group, a t-butyl group, an n-octyl group, and a 2-ethylhexyl group are preferable in terms of exerting a whitening effect.

  The production method of the hydroxynicotinic acid ester derivative of the present invention is not particularly limited, and can be produced by a known production method. Specifically, it can be synthesized by esterifying hydroxynicotinic acid and various alcohols in the presence of an acid catalyst.

  The blending amount of the hydroxynicotinic acid or derivative thereof of the present invention into a cosmetic or skin external preparation is not particularly limited, but is preferably 0.01 to 50% by weight, more preferably 0.05 to 20% by weight.

  The hydroxynicotinic acid or derivative thereof of the present invention can be used synergistically by using it in combination with known antioxidants, whitening agents and the like.

  The cosmetic or skin external preparation containing the hydroxynicotinic acid of the present invention or a derivative thereof, as necessary, is generally added to cosmetics or skin external preparations, for example, oily base, moisturizing agent, touch Improver, surfactant, polymer, thickener / gelator, solvent, propellant, antioxidant, reducing agent, oxidizing agent, antibacterial agent, preservative, chelating agent, pH adjuster, acid, alkali, powder Body, inorganic salts, UV absorbers, whitening agents, vitamins and derivatives thereof, anti-inflammatory agents, anti-inflammatory agents, hair growth agents, blood circulation promoters, stimulants, hormones, anti-wrinkle agents, anti-aging agents, tanning agents , Cold sensation agent, warming sensation agent, wound healing promoter, irritation relieving agent, analgesic agent, cell activator, plant / animal / microbe extract, antipruritic agent, exfoliating / dissolving agent, antiperspirant, refreshing agent, astringent , Enzyme, nucleic acid, fragrance, pigment, colorant, dye, pigment, water, etc. Door can be.

  Examples of oily bases include cetanol, myristyl alcohol, oleyl alcohol, lauryl alcohol, cetostearyl alcohol, stearyl alcohol, aralkyl alcohol, behenyl alcohol, jojoba alcohol, chimyl alcohol, ceralkyl alcohol, batyl alcohol, hexyldecanol, isostearyl alcohol, Higher alcohols such as 2-octyldodecanol and dimer diol; aralkyl alcohols and derivatives such as benzyl alcohol; lauric acid, myristic acid, palmitic acid, stearic acid, isostearic acid, behenic acid, undecylenic acid, 12-hydroxystearic acid, Palmitooleic acid, oleic acid, linoleic acid, linolenic acid, erucic acid, docosahexaenoic acid, eicosapentaenoic acid, isohexa Higher fatty acids such as cannic acid, anteisohenicosanoic acid, long-chain branched fatty acid, dimer acid, hydrogenated dimer acid, and metal soaps such as aluminum salts, calcium salts, magnesium salts, zinc salts, potassium, sodium salts, etc. And nitrogen-containing derivatives such as amides; liquid paraffin (mineral oil), heavy liquid isoparaffin, light liquid isoparaffin, α-olefin oligomer, polyisobutene, hydrogenated polyisobutene, polybutene, squalane, olive-derived squalane, squalene, petrolatum, solid Type hydrocarbons such as candelilla wax, carnauba wax, rice wax, wax, beeswax, montan wax, ozokerite, ceresin, paraffin wax, microcrystalline wax, petrolatum, fisher Tropsch wax, polyethylene wax, waxes such as ethylene / propylene copolymer; palm oil, palm oil, palm kernel oil, safflower oil, olive oil, castor oil, avocado oil, sesame oil, tea oil, evening primrose oil, wheat germ oil, macadamia nut Oil, hazelnut oil, cucumber oil, rosehip oil, meadow foam oil, persic oil, tea tree oil, peppermint oil, corn oil, rapeseed oil, sunflower oil, wheat germ oil, linseed oil, cottonseed oil, soybean oil, peanut oil, rice bran Vegetable oils such as oil, cacao butter, shea fat, hydrogenated coconut oil, hydrogenated castor oil, jojoba oil, hydrogenated jojoba oil; animal properties such as beef tallow, milk fat, horse fat, egg yolk oil, mink oil, turtle oil Fats and oils; animal waxes such as whale wax, lanolin, orange luffy oil; liquid lanolin, reduced lanoli Lanolins such as adsorption purified lanolin, lanolin acetate, liquid lanolin acetate, hydroxy lanolin, polyoxyethylene lanolin, lanolin fatty acid, hard lanolin fatty acid, lanolin alcohol, lanolin alcohol acetate, acetic acid (cetyl lanolyl) ester; lecithin, phosphatidylcholine, Phosphatidylethanolamine, phosphatidylserine, phosphatidylglycerol, phosphatidylinositol, sphingophospholipids such as sphingomyelin, phospholipids such as phosphatidic acid, lysolecithin; hydrogenated soybean phospholipid, partially hydrogenated soybean phospholipid, hydrogenated egg yolk phospholipid, Phospholipid derivatives such as partially hydrogenated egg yolk phospholipids; cholesterol, dihydrocholesterol, lanosterol, dihydrolanosterol, phytoster Sterols such as oleol and cholic acid; sapogenins; saponins; cholesteryl acetate, cholesteryl nonanoate, cholesteryl stearate, cholesteryl isostearate, cholesteryl oleate, di-N-lauroyl-L-glutamate (cholesteryl / behenyl / octyldodecyl ), N-lauroyl-L-glutamate di (cholesteryl / octyldodecyl), N-lauroyl-L-glutamate di (phytosteryl / behenyl / octyldodecyl), N-lauroyl-L-glutamate di (phytosteryl / octyldodecyl), N Acyl sarcosine alkyl esters such as lauroyl sarcosine isopropyl, cholesteryl 12-hydroxystearate, macadamia nut oil fatty acid cholesteryl, macadamia nut oil fatty acid phyto Sterol esters such as steryl, phytosteryl isostearate, soft lanolin fatty acid cholesteryl, hard lanolin fatty acid cholesteryl, long chain branched fatty acid cholesteryl, long chain α-hydroxy fatty acid cholesteryl; phospholipid / cholesterol complex, phospholipid / phytosterol complex, etc. Lipid complex: octyldodecyl myristate, hexyl decyl myristate, octyl dodecyl isostearate, cetyl paritate, octyldodecyl palmitate, cetyl octanoate, hexyl decyl octanoate, isotridecyl isononanoate, isononyl isononanoate, isononanoate Isotridecyl acid, isodecyl neopentanoate, isotridecyl neopentanoate, isostearyl neopentanoate, octeodecanoate Ludodecyl, oleyl oleate, octyldodecyl oleate, octyldodecyl ricinoleate, lanolin fatty acid octyldodecyl, hexyldecyl dimethyloctanoate, octyldodecyl erucate, isostearic acid hydrogenated castor oil, ethyl oleate, ethyl avocado oil, isopropyl myristate , Isopropyl palmitate, octyl palmitate, isopropyl isostearate, lanolin fatty acid isopropyl, diethyl sebacate, diisopropyl sebacate, dioctyl sebacate, diisopropyl adipate, dibutyl octyl sebacate, diisobutyl adipate, dioctyl succinate, triethyl citrate, etc. Monoalcohol carboxylic acid esters; cetyl lactate, diisostearyl malate, monoisostearyl Oxyacid esters such as acid hydrogenated castor oil; glyceryl trioctanoate, glyceryl trioleate, glyceryl triisostearate, glyceryl diisostearate, glyceryl tri (caprylic / capric), tri (caprylic / capric / myristin) Acid / stearic acid) glyceryl, hydrogenated rosin triglyceride (hydrogenated ester gum), rosin triglyceride (ester gum), glyceryl behenate, trimethylolpropane trioctanoate, trimethylolpropane triisostearate, neopentyl glycol dioctanoate , Neopentyl glycol dicaprate, 2-butyl-2-ethyl-1,3-propanediol dioctanoate, propylene glycol dioleate, pentaerythrtetraoctanoate Chill, hydrogenated rosin pentaerythrityl, triethylhexanoic acid ditrimethylolpropane, (isostearic acid / sebacic acid) ditrimethylolpropane, triethylhexanoic acid pentaerythrityl, (hydroxystearic acid / stearic acid / rosinic acid) dipentaerythrityl, diisostearic acid di Glyceryl, polyglyceryl tetraisostearate, polyglyceryl-10 nonaisostearate, deca (erucic acid / isostearic acid / ricinoleic acid) polyglyceryl-8, (hexyldecanoic acid / sebacic acid) diglyceryl oligoester, glycol distearate (ethylene glycol distearate) , Dineopentanoic acid 3-methyl-1,5-pentanediol, dineopentanoic acid 2,4-diethyl-1,5-pentane Polyhydric alcohol fatty acid esters such as ol; dimer dilinoleate diisopropyl, dimer dilinoleate diisostearyl, dimer dilinoleate di (isostearyl / phytosteryl), dimer dilinoleate (phytosteryl / behenyl), dimer dilinoleate (Phytosteryl / isostearyl / cetyl / stearyl / behenyl), dimer dilinoleic acid dimer dilinoleyl, diisostearic dimer dilinoleyl, dimer dilinoleyl hydrogenated rosin condensate, dimer dilinoleic acid hydrogenated castor oil, hydroxyalkyl die Dimer acid or dimer diol derivative such as merlinoleyl ether; coconut oil fatty acid monoethanolamide (cocamide MEA), coconut oil fatty acid diethanolamide (cocamide DEA), Lauri Acid monoethanolamide (lauramide MEA), lauric acid diethanolamide (lauramide DEA), lauric acid monoisopropanolamide (lauramide MIPA), palmitic acid monoethanolamide (partamide MEA), palmitic acid diethanolamide (partamide DEA), coconut oil Fatty acid alkanolamides such as fatty acid methylethanolamide (cocamidomethyl MEA); dimethicone (dimethylpolysiloxane), highly polymerized dimethicone (highly polymerized dimethylpolysiloxane), cyclomethicone (cyclic dimethylsiloxane, decamethylcyclopentasiloxane), phenyltrimethicone , Diphenyldimethicone, phenyldimethicone, stearoxypropyldimethylamine, (aminoethylaminopropylmethicone / dimethicone) Polymer, dimethiconol, dimethiconol crosspolymer, silicone resin, silicone rubber, amino-modified silicone such as aminopropyl dimethicone and amodimethicone, cation-modified silicone, polyether-modified silicone such as dimethicone copolyol, polyglycerin-modified silicone, sugar-modified silicone, carvone Acid-modified silicone, phosphoric acid-modified silicone, sulfuric acid-modified silicone, alkyl-modified silicone, fatty acid-modified silicone, alkyl ether-modified silicone, amino acid-modified silicone, peptide-modified silicone, fluorine-modified silicone, cation-modified and polyether-modified silicone, amino-modified and poly-modified Ether-modified silicone, alkyl-modified and polyether-modified silicone, polysiloxane-oxyalkylene copolymer Silicones such as body; perfluorodecane, perfluorooctane, fluorine-based oils such as perfluoropolyether may be mentioned as preferred.

  As the humectant / feel improver, glycerin, 1,3-butylene glycol, propylene glycol, 3-methyl-1,3-butanediol, 1,3-propanediol, 2-methyl-1,3-propanediol, Polyols such as trimethylolpropane, pentaerythritol, hexylene glycol, diglycerin, polyglycerin, diethylene glycol, polyethylene glycol, dipropylene glycol, polypropylene glycol, ethylene glycol / propylene glycol copolymer and polymers thereof; diethylene glycol monoethyl ether (Ethoxydiglycol), ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol dibutyl ether, etc. (Eicosane diacid / tetradecanedioic acid) water-soluble esters such as polyglyceryl-10, tetradecanedioic acid polyglyceryl-10, and cyclohexanedicarboxylic acid bisethoxydiglycol; sugars such as sorbitol, xylitol, erythritol, mannitol, maltitol Alcohols; glucose, fructose, galactose, mannose, threose, xylose, arabinose, fucose, ribose, deoxyribose, maltose, trehalose, lactose, raffinose, gluconic acid, glucuronic acid, cyclodextrins (α-, β-, γ- Cyclodextrins and modified cyclodextrins such as maltosylation and hydroxyalkylation), β-glucan, chitin, chitosan, heparin and derivatives, pectin, arabino Sugars and derivatives thereof such as galactan, dextrin, dextran, glycogen, ethyl glucoside, glucosylethyl methacrylate polymer or copolymer; hyaluronic acid, sodium hyaluronate; sodium chondroitin sulfate; mucoitin sulfate, caroline sulfate, keratosulfate, dermatan Sulfuric acid; white jellyfish extract; white jellyfish polysaccharide; fucoidan; tuberose polysaccharide, naturally derived polysaccharide; organic acids such as citric acid, tartaric acid, lactic acid and their salts; urea; 2-pyrrolidone-5-carboxylic acid and its sodium Salt: betaine (trimethylglycine), proline, hydroxyproline, arginine, lysine, serine, glycine, alanine, phenylalanine, tyrosine, β-alanine, threonine, glutamic acid, glutamine, aspa Amino acids such as gin, aspartic acid, cysteine, cystine, methionine, leucine, isoleucine, valine, tryptophan, histidine, taurine and the salts thereof; collagen, fish-derived collagen, atelocollagen, gelatin, elastin, collagenolytic peptide, hydrolyzed collagen, Hydroxypropylammonium chloride hydrolyzed collagen, elastin degrading peptide, keratin degrading peptide, hydrolyzed keratin, conchiolin degrading peptide, hydrolyzed conchiolin, silk proteolytic peptide, hydrolyzed silk, lauroyl hydrolyzed silk sodium, soy proteolytic peptide, wheat protein Degraded peptides, hydrolyzed wheat protein, casein-degraded peptides, acylated peptides and other protein peptides and their derivatives; palmitoyl oligopeptides , Acylated peptides such as palmitoyl pentapeptide, palmitoyl tetrapeptide; silylated peptides; lactic acid bacteria culture solution, yeast extract, eggshell membrane protein, bovine submandibular gland mucin, hypotaurine, sesameignan glycoside, glutathione, albumin, milk Chin; choline chloride, phosphorylcholine; placenta extract, aerostin, collagen, aloe extract, hamamelis water, loofah water, chamomile extract, licorice extract, comfrey extract, silk extract, Izayoi rose extract, yarrow extract, eucalyptus extract, merirot extract Preferred are ceramides such as animal and plant extract components such as natural ceramides (types 1, 2, 3, 4, 5, 6), hydroxyceramide, pseudoceramide, glycosphingolipid, ceramide, and sugar-ceramide-containing extracts. All It is.

Preferred examples of the surfactant include an anionic surfactant, a nonionic surfactant, a cationic surfactant, an amphoteric surfactant, and a polymer surfactant. There is no restriction | limiting in particular in HLB of surfactant, It can use from about 1 low thing to about 20 high thing, It is also preferable to combine a low thing and a high thing of HLB. Examples of preferable surfactants include fatty acid salts such as potassium laurate and potassium myristate; alkyl sulfates such as sodium lauryl sulfate, triethanolamine lauryl sulfate, and ammonium lauryl sulfate; laureth Polyoxyethylene alkyl sulfates such as sodium sulfate and laureth sulfate triethanolamine; cocoyl methyl taurine sodium, cocoyl methyl taurine potassium, lauroyl methyl taurine sodium, myristoyl methyl taurine sodium, lauroyl methyl alanine sodium, lauroyl sarcosine sodium, lauroyl sarcosine triethanol Acyl N-methyl amino acid salts such as amines and sodium methylalanine lauroylglutamate; Cocoyl Glue Acyl amino acid salts such as sodium minate, triethanolamine cocoyl glutamate, sodium lauroyl glutamate, sodium myristoyl glutamate, sodium stearoyl glutamate, ditriethanolamine palmitoyl aspartate, cocoylalanine triethanolamine; polyoxyethylene alkyl ethers such as sodium laureth acetate Acetic acid salt; Succinic acid ester salt such as sodium lauroyl monoethanolamide succinate; Fatty acid alkanolamide ether carboxylate; Acyl lactate; Polyoxyethylene fatty amine sulfate; Fatty acid alkanolamide sulfate; Hardened coconut oil fatty acid sodium glyceryl sulfate Fatty acid glyceride sulfate such as alkylbenzene polyoxyethylene sulfate; α-olefin Olefin sulfonates such as sodium sulfonate; alkylsulfosuccinates such as disodium lauryl sulfosuccinate and dioctyl sodium sulfosuccinate; disodium laureth sulfosuccinate, monolauroyl monoethanolamide polyoxyethylene sodium sulfosuccinate, lauryl polypropylene glycol sulfosuccinic acid Alkyl ether sulfosuccinates such as sodium; alkylbenzene sulfonates such as sodium tetradecylbenzenesulfonate and tetraethanolamine tetraethanol; alkylnaphthalenesulfonates; alkanesulfonates; α-sulfo fatty acid methyl ester salts; Acyl isethionate; alkyl glycidyl ether sulfonate; alkyl sulfoacetate; laurethrin Alkyl ether phosphates such as sodium, sodium dilaureth phosphate, sodium trilaureth phosphate, sodium monooles phosphate; alkyl phosphate salts such as potassium lauryl phosphate; sodium caseinate; alkyl aryl ether phosphate; fatty acid amide ether phosphorus Phospholipids such as phosphatidylglycerol, phosphatidylinositol, and phosphatidic acid; silicone anionic surfactants such as carboxylic acid-modified silicone, phosphate-modified silicone, and sulfate-modified silicone; and nonionic surfactants, laureth (Polyoxyethylene lauryl ether), ceteth (polyoxyethylene cetyl ether), steareth (polyoxyethylene stearyl ether), behenez (polyoxyethylene) Nbehenyl ethers), isosteares (polyoxyethylene isostearyl ethers), octyldecesses (polyoxyethylene octyldodecyl ethers) and other polyoxyethylene alkyl ethers with various polyoxyethylene addition numbers; polyoxyethylene alkylphenyl ethers; Polyoxyethylene hydrogenated castor oil, polyoxyethylene castor oil, polyoxyethylene hydrogenated castor oil monoisostearate, polyoxyethylene hydrogenated castor oil triisostearate, polyoxyethylene hydrogenated castor oil monopyroglutamic acid monoisostearate diester, poly Castor oil such as oxyethylene hydrogenated castor oil maleic acid and hydrogenated castor oil derivatives; polyoxyethylene phytosterol; polyoxyethylene cholesterol; polyoxy Polyoxyethylene lanolin; polyoxyethylene reduced lanolin; polyoxyethylene polyoxypropylene cetyl ether, polyoxyethylene polyoxypropylene 2-decyltetradecyl ether, polyoxyethylene polyoxypropylene monobutyl ether, polyoxyethylene lanolin; Oxyethylene / polyoxypropylene hydrogenated lanolin, polyoxyethylene / polyoxypropylene alkyl ethers such as polyoxyethylene / polyoxypropylene glycerin ether; polyoxyethylene / polyoxypropylene glycol; (poly) such as PPG-9 diglyceryl Glycerin polyoxypropylene glycol; glyceryl stearate, glyceryl isostearate, glyceryl palmitate, myristate group Glyceryl fatty acid partial esters such as ceryl, glyceryl oleate, glyceryl coconut fatty acid, mono-cotton oil fatty acid glycerin, glyceryl monoerucate, glyceryl sesquioleate, α, α'-oleic acid pyroglutamic acid glycerin, monostearic acid glycerin malic acid; Polyglyceryl stearate-2, 3, 4, 5, 6, 8, 10, polyglyceryl distearate-6, 10, polyglyceryl tristearate, polyglyceryl decastearate-10, polyglyceryl isostearate -2, 3, 4, 5, 6, 8, 10, diglycostyl diisostearate (diglyceryl diisostearate), 3, 10, polyglyceryl-2 triisostearate, polyglyceryl tetraisostearate Ril-2, polyglyceryl-10 decaisostearate, polyglyceryl-2 oleate, 3,4, 5,6, 8,8, dioleate polyglyceryl-6, trioleate polyglyceryl-2, dekaoleic acid Polyglyceryl fatty acid esters such as polyglyceryl-10; ethylene glycol monofatty acid esters such as ethylene glycol monostearate; propylene glycol monofatty acid esters such as propylene glycol monostearate; pentaerythritol partial fatty acid esters; sorbitol partial fatty acid esters; maltitol moieties Fatty acid ester; maltitol ether; sorbitan monooleate, sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monos Sorbitan fatty acid esters such as allate, sorbitan sesquioleate, sorbitan trioleate, diglycerol sorbitan penta-2-ethylhexylate, diglycerol sorbitan tetra-2-ethylhexylate; sucrose fatty acid ester, methyl glucoside fatty acid ester, trehalose undecylenate, etc. Partial derivatives of sugar derivatives; alkyl glucosides such as caprylyl glucoside; alkyl polyglycosides; lanolin alcohols; reduced lanolin; polyoxyethylene distearate, polyethylene glycol diisostearate, polyoxyethylene monooleate, polyoxyethylene di- Polyoxyethylene fatty acid mono- and diesters such as oleate; polyoxyethylene propylene glycol fatty acid ester; polyoxyethylene Polyoxyethylene glycerin fatty acid esters such as polyoxyethylene monooleate such as polyglycerin monostearate, polyoxyethylene glycerin monoisostearate, polyoxyethylene glycerin triisostearate; polyoxyethylene sorbitan monooleate, polyoxy Polyoxyethylene sorbitan fatty acid esters such as ethylene sorbitan monostearate, polyoxyethylene sorbitan monooleate, polyoxyethylene sorbitan tetraoleate; polyoxyethylene sorbitol monolaurate, polyoxyethylene sorbitol monooleate, polyoxyethylene sorbitol penta Polyoxyethylene sorbitol fatty acid esters such as oleate and polyoxyethylene sorbitol monostearate Polyoxyethylene methyl glucoside fatty acid ester; Polyoxyethylene alkyl ether fatty acid ester; Polyoxyethylene animal and vegetable oils such as polyoxyethylene sorbitol beeswax; Alkyl such as isostearyl glyceryl ether, chimyl alcohol, ceralkyl alcohol, batyl alcohol Glyceryl ethers; polyhydric alcohol alkyl ethers; polyoxyethylene alkylamines; tetrapolyoxyethylene / tetrapolyoxypropylene-ethylenediamine condensates; natural surfactants such as saponins and sophorolipids; polyoxyethylene fatty acid amides; coconut oil Fatty acid monoethanolamide (cocamide MEA), coconut oil fatty acid diethanolamide (cocamide DEA), lauric acid monoethanolamide (laura) De MEA), lauric acid diethanolamide (lauramide DEA), lauric acid monoisopropanolamide (lauramide MIPA), palmitic acid monoethanolamide (partamide MEA), palmitic acid diethanolamide (partamide DEA), palm oil fatty acid methyl ethanolamide (cocamidomethyl) Fatty acid alkanolamides such as MEA); alkyldimethylamine oxides such as lauramine oxide, cocamamine oxide, stearamine oxide, and behenamine oxide; alkylethoxydimethylamine oxide; polyoxyethylene alkyl mercaptan; poly such as dimethicone copolyol Silicone such as ether-modified silicone, polysiloxane-oxyalkylene copolymer, polyglycerin-modified silicone, sugar-modified silicone Nonionic surfactants, etc .; for cationic surfactants, alkyltrimethylammonium chlorides such as behentrimonium chloride, steartrimonium chloride, cetrimonium chloride, lauryltrimonium chloride; alkyls such as stearyltrimonium bromide Trimethylammonium bromides; dialkyldimethylammonium chlorides such as distearyldimonium chloride and dicocodimonium chloride; fatty acid amidoamines and salts thereof such as stearamidepropyldimethylamine and stearamideethyldiethylamine; alkyl ether amines such as stearoxypropyldimethylamine; Salt or quaternary salt thereof; ethyl sulfate long chain branched fatty acid (12-31) aminopropylethyldimethylammonium, ethyl lanolin sulfate Fatty acid amide-type quaternary ammonium salts such as aminopropylethyldimethylammonium fatty acid; polyoxyethylene alkylamine and its salts or quaternary salts; alkylamine salts; fatty acid amidoguanidinium salts; alkyl etheraminemonium salts; Benzalkonium salt; Pyridinium salt such as cetylpyridinium chloride; Imidazolinium salt; Alkylisoquinolinium salt; Dialkyl morpholinium salt; Polyamine fatty acid derivatives; Aminopropyl dimethicone and amodimethicone Silicone-based cationic surfactants such as amino-modified silicone, cation-modified silicone, cation-modified and polyether-modified silicone, amino-modified and polyether-modified silicone;
In amphoteric surfactants, N-alkyl-N, N-dimethylamino acid betaines such as lauryl betaine (lauryldimethylaminoacetic acid betaine); fatty acid amide alkyl-N, N-dimethylamino acids such as cocamidopropyl betaine and lauramidopropyl betaine Betaines; imidazoline-type betaines such as sodium cocoamphoacetate and sodium lauroamphoacetate; alkylsulfobetaines such as alkyldimethyltaurine; sulfate-type betaines such as alkyldimethylaminoethanol sulfate; phosphate-type betaines such as alkyldimethylaminoethanol phosphate; Sphingophospholipids such as phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, sphingomyelin, lysolecithin, hydrogenated soybean phospholipid, partially hydrogenated Phospholipids such as soybean phospholipid, hydrogenated egg yolk phospholipid, partially hydrogenated egg yolk phospholipid, and hydroxylated lecithin; silicone-based amphoteric surfactants; polymer surfactants such as polyvinyl alcohol, sodium alginate, starch derivatives, Preferred are tragacanth gum, acrylic acid / alkyl methacrylate copolymer; and various silicone surfactants.

  Polymers, thickeners and gelling agents include guar gum, locust bean gum, queens seed, carrageenan, galactan, arabic gum, tara gum, tamarind, far selelain, karaya gum, troarooi, cara gum, tragacanth gum, pectin, pectic acid and sodium Salt such as salt, salt such as alginic acid and sodium salt, mannan; starch such as rice, corn, potato, wheat; xanthan gum, dextran, succinoglucan, curdlan, hyaluronic acid and its salt, xanthan gum, pullulan, gellan gum, chitin , Chitosan, agar, gypsum extract, chondroitin sulfate, casein, collagen, gelatin, albumin; methylcellulose, ethylcellulose, hydroxyethylcellulose, hydroxypropi Cellulose, carboxymethylcellulose and its salts such as sodium, methylhydroxypropylcellulose, sodium cellulose sulfate, cellulose dialkyldimethylammonium sulfate, crystalline cellulose, cellulose powder such as cellulose powder; soluble starch, carboxymethyl starch, methylhydroxypropyl starch, Starch-based polymers such as methyl starch, starch derivatives such as hydroxypropyltrimonium chloride, octenyl succinate corn starch and aluminum; alginic acid derivatives such as sodium alginate and propylene glycol alginate; polyvinylpyridone (PVP), polyvinyl alcohol (PVA), Vinyl pydridone-vinyl alcohol copolymer, polyvinyl methyl ether Polyethylene glycol, polypropylene glycol, polyoxyethylene / polyoxypropylene copolymer; amphoteric methacrylic acid such as (methacryloyloxyethylcarboxybetaine / alkyl methacrylate) copolymer, (acrylates / stearyl acrylate / ethylamine methacrylate oxide) copolymer, etc. Ester copolymer; (Dimethicone / vinyl dimethicone) crosspolymer, (alkyl acrylate / diacetone acrylamide) copolymer, (alkyl acrylate / diacetone acrylamide) copolymer AMP; Polyvinyl acetate partial saponification product, maleic acid copolymer; Vinylpyrrolidone / dialkylaminoalkyl methacrylate copolymer; acrylic resin alkanolamine; polyester, water-dispersible polyester; Kurylamide; Polyacrylic acid ester copolymer such as polyethyl acrylate, carboxyvinyl polymer, polyacrylic acid and its sodium salt, acrylic acid / methacrylic acid ester copolymer; acrylic acid / alkyl methacrylate Polymer: Cationized cellulose such as polyquaternium-10, diallyldimethylammonium chloride / acrylamide copolymer such as polyquaternium-7, acrylic acid / diallyldimethylammonium chloride copolymer such as polyquaternium-22, and acrylic acid such as polyquaternium-39・ Diallyldimethylammonium chloride / acrylamide copolymer, acrylic acid / cationized methacrylic acid ester copolymer, acrylic acid / cationized methacrylic acid amide copolymer, polyquaternium Acrylic acid / methyl acrylate / methacrylamidopropyltrimethylammonium chloride copolymer such as 47, methacrylic acid choline ester polymer; cationized polysaccharides such as cationized oligosaccharide, cationized dextran, guar hydroxypropyltrimonium chloride; Polyethyleneimine; Cationic polymer; Polymer of 2-methacryloyloxyethyl phosphorylcholine such as polyquaternium-51 and copolymer with butyl methacrylate copolymer; Acrylic resin emulsion, polyethyl acrylate emulsion, polyacrylalkyl ester emulsion, Polymer emulsions such as polyvinyl acetate resin emulsion, natural rubber latex, synthetic latex; nitrocellulose; polyurethanes and various copolymers; various silicones Various silicone-based copolymers such as acrylic-silicone graft copolymers; various fluoropolymers; 12-hydroxystearic acid and its salts; dextrin fatty acid esters such as dextrin palmitate and dextrin myristate; silicic anhydride, Smoke-like silica (ultrafine silicic anhydride), aluminum magnesium silicate, magnesium magnesium silicate, metal soap, dialkyl phosphate metal salt, bentonite, hectorite, organically modified clay mineral, sucrose fatty acid ester, fructooligosaccharide fatty acid ester It is mentioned as preferable.

  Solvents and propellants include ethanol, 2-propanol (isopropyl alcohol), butanol, isobutyl alcohol and other lower alcohols; propylene glycol, 1,3-butylene glycol, diethylene glycol, dipropylene glycol, isopentyl diol and other glycols Diethylene glycol monoethyl ether (ethoxydiglycol), ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, triethylene glycol monoethyl ether, diethylene glycol diethyl ether, diethylene glycol dibutyl ether, propylene glycol monoethyl ether, dipropylene glycol monoethyl ether Glycol ethers such as ethylene glycol monoethyl ether Glycol ether esters such as acetate, diethylene glycol monoethyl ether acetate, propylene glycol monoethyl ether acetate; Glycol esters such as diethoxyethyl succinate, ethylene glycol disuccinate; benzyl alcohol, benzyloxyethanol, propylene carbonate, dialkyl carbonate , Acetone, ethyl acetate, N-methylpyrrolidone; toluene; fluorocarbon, next-generation flon; propellants such as LPG, dimethyl ether, carbon dioxide, and the like are preferable.

  Antioxidants include tocopherol derivatives such as tocopherol (vitamin E) and tocopherol acetate; BHT, BHA; gallic acid derivatives such as propyl gallate; vitamin C (ascorbic acid) and / or derivatives thereof; erythorbic acid and derivatives thereof; Preferred are sulfites such as sodium sulfite; bisulfites such as sodium bisulfite; thiosulfates such as sodium thiosulfate; metabisulfites; thiotaurine, hypotaurine; thioglycerol, thiourea, thioglycolic acid, cysteine hydrochloride As mentioned. Preferred examples of the reducing agent include thioglycolic acid, cysteine, cysteamine and the like. Preferred examples of the oxidizing agent include aqueous hydrogen peroxide, ammonium persulfate, sodium bromate, and percarbonate.

  Antibacterial agents or antiseptics include parabens (hydroxybenzoic acid esters) such as methylparaben, ethylparaben, propylparaben and butylparaben; phenoxyethanol; 1,2-pentanediol, 1,2-hexanediol, 1,2-octane 1,2-alkanediols such as diol; alkyl glyceryl ethers such as 2-ethylhexyl glyceryl ether (ethylhexyl glycerin); salicylic acid; sodium benzoate; isothiazoline derivatives such as methyl chloroisothiazolinone and methylisothiazolinone; Dehydroacetic acid and its salts; phenols; halogenated bisphenols such as triclosan, acid amides, quaternary ammonium salts; trichlorocarbanide, zinc pyrithione, benzoyl chloride Luconium, benzethonium chloride, sorbic acid, chlorhexidine, chlorhexidine gluconate, halocarban, hexachlorophene, hinokitiol; other phenols such as phenol, isopropylphenol, cresol, thymol, parachlorophenol, phenylphenol, sodium phenylphenol; phenylethyl alcohol , Photosensitizers, antibacterial zeolite, and silver ion are preferable, but when used as an antibacterial agent or antiseptic agent for antiseptic purposes, phenoxyethanol; 1 from the viewpoint of safety of cosmetics or skin external preparations; 1,2-alkanediols such as 1,2-pentanediol, 1,2-hexanediol, 1,2-octanediol; alkyl glyceres such as 2-ethylhexyl glyceryl ether It is more preferred to use ethers.

  Examples of chelating agents include edetate (ethylenediaminetetraacetate) such as EDTA, EDTA2Na, EDTA3Na, and EDTA4Na; hydroxyethylethylenediaminetriacetate such as HEDTA3Na; pentetate (diethylenetriaminepentaacetate); phytic acid; Phosphonic acid and its sodium salt; sodium oxalate; polypolyamino acids such as polyaspartic acid and polyglutamic acid; sodium polyphosphate, sodium metaphosphate, phosphoric acid; sodium citrate, citric acid, alanine, dihydroxyethylglycine Gluconic acid, ascorbic acid, succinic acid, and tartaric acid are preferable. pH adjusters / acids / alkalis include citric acid, sodium citrate, lactic acid, sodium lactate, glycolic acid, succinic acid, acetic acid, sodium acetate, malic acid, tartaric acid, fumaric acid, phosphoric acid, hydrochloric acid, sulfuric acid, monoethanol Amine, diethanolamine, triethanolamine, isopropanolamine, triisopropanolamine, 2-amino-2-methyl-1,3-propanediol, 2-amino-2-hydroxymethyl-1,3-propanediol, arginine, hydroxylation Sodium, potassium hydroxide, aqueous ammonia, guanidine carbonate, and ammonium carbonate are preferable.

  Examples of powders include mica, talc, kaolin, sericite, montmorillonite, kaolinite, mica, muscovite, phlogopite, synthetic mica, red mica, biotite, permiculite, magnesium carbonate, calcium carbonate, aluminum silicate, silica Barium acid, calcium silicate, magnesium silicate, strontium silicate, metal tungstate, magnesium, zeolite, barium sulfate, calcined calcium sulfate, calcium phosphate, fluorine apatite, hydroxyapatite, ceramic powder, bentonite, smectite, clay, mud, Metal soap (e.g. zinc myristate, calcium palmitate, aluminum stearate), calcium carbonate, bengara, yellow iron oxide, black iron oxide, ultramarine, bitumen, carbon black, titanium oxide, fine particles and ultrafine Titanium oxide, zinc oxide, fine and ultrafine zinc oxide, alumina, silica, fumed silica (ultrafine silica), titanium mica, fish scale foil, boron nitride, photochromic pigment, synthetic fluorophlogopite, fine particle composite powder Body, gold, aluminum, etc., various sizes and shapes of inorganic powders, and these are treated with various surface treatment agents such as hydrogen silicone, cyclic hydrogen silicone, or other silane or titanium coupling agents Inorganic powders such as hydrophobized or hydrophilized powders; starch, cellulose, nylon powder, polyethylene powder, polymethyl methacrylate powder, polystyrene powder, copolymer resin powder of styrene and acrylic acid, polyester powder, Benzoguanamine resin powder, polyethylene terephthalate, polymethyl Organic powders and surface-treated powders of various sizes and shapes, such as methacrylate powder, polyethylene terephthalate / aluminum / epoxy powder, urethane powder, silicone powder, Teflon (registered trademark) powder, organic-inorganic composite powder Is preferable. Inorganic salts include sodium chloride-containing salts such as salt, common salt, rock salt, sea salt, natural salt; potassium chloride, aluminum chloride, calcium chloride, magnesium chloride, bittern, zinc chloride, ammonium chloride; sodium sulfate, aluminum sulfate, Aluminum sulfate / potassium sulfate (alum), aluminum sulfate / ammonium sulfate, barium sulfate, calcium sulfate, potassium sulfate, magnesium sulfate, zinc sulfate, iron sulfate, copper sulfate; sodium phosphates such as 1Na, 2Na and 3Na phosphates, phosphoric acid Potassium, calcium phosphates and magnesium phosphates are preferred.

Examples of ultraviolet absorbers include paraaminobenzoic acid, paraaminobenzoic acid monoglycerin ester, N, N-dipropoxyparaaminobenzoic acid ethyl ester, N, N-diethoxyparaaminobenzoic acid ethyl ester, and N, N-dimethylparaaminobenzoic acid ethyl ester. Benzoic acid-based ultraviolet absorbers such as esters, N, N-dimethylparaaminobenzoic acid butyl ester, N, N-dimethylparaaminobenzoic acid ethyl ester; Anthranilic acid-based ultraviolet absorbers such as homomenthyl-N-acetylanthranilate; Salicylic acid And salicylic acid-based purple such as sodium salt, amyl salicylate, menthyl salicylate, homomenthyl salicylate, octyl salicylate, phenyl salicylate, benzyl salicylate, p-isopropanol phenyl salicylate Line absorber: Octyl cinnamate, ethyl-4-isopropyl cinnamate, methyl-2,5-diisopropyl cinnamate, ethyl-2,4-diisopropyl cinnamate, methyl-2,4-diisopropyl cinnamate, propyl-p- Methoxycinnamate, isopropyl-p-methoxycinnamate, isoamyl-p-methoxycinnamate, 2-ethylhexyl p-methoxycinnamate (octyl paramethoxycinnamate), 2-ethoxyethyl-p-methoxycinnamate (sinoxate), Cyclohexyl-p-methoxycinnamate, ethyl-α-cyano-β-phenylcinnamate, 2-ethylhexyl α-cyano-β-phenylcinnamate (octocrine), glyceryl mono-2-ethylhexanoyl-diparamethoxy Nameto, cinnamic acid UV absorbers such as ferulic acid and its derivatives; 2,4-dihydroxybenzophenone, 2,2'-
Dihydroxy-4-methoxybenzophenone, 2,2′-dihydroxy-4,4′-dimethoxybenzophenone, 2,2 ′, 4,4′-tetrahydroxybenzophenone, 2-hydroxy-4-
Methoxybenzophenone (oxybenzone-3), 2-hydroxy-4-methoxy-4'-methylbenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonate, 4-phenylbenzophenone, 2-ethylhexyl-4'-phenyl -Benzophenone ultraviolet absorbers such as benzophenone-2-carboxylate, 2-hydroxy-4-n-octoxybenzophenone, 4-hydroxy-3-carboxybenzophenone; 3- (4'-methylbenzylidene) -d, l- Camphor, 3-benzylidene-d, l-camphor; 2-phenyl-5-methylbenzoxazole; 2,2'-hydroxy-5-methylphenylbenzotriazole; 2- (2'-hydroxy-5'-t- Octylphenyl) benzotriazole; 2- (2′-H Dioxy-5'-methylphenylbenzotriazole;dibenzalazine;dianisoylmethane; 5- (3,3-dimethyl-2-norbornylidene) -3-pentan-2-one; di- such as 4-t-butylmethoxydibenzoylmethane Benzoylmethane derivatives; octyl triazone; urocanic acid derivatives such as urocanic acid and ethyl urocanate; 2- (2′-hydroxy-5′-methylphenyl) benzotriazole, 1- (3,4-dimethoxyphenyl) -4, Hydantoin derivatives such as 4-dimethyl-1,3-pentanedione, dimethoxybenzylidenedioxoimidazolidinepropionate 2-ethylhexyl, phenylbenzimidazolazole sulfonic acid, terephthalylidene dicamphulsulfonic acid, drometrizol trisiloxane, anthranyl Methyl, rutin and its derivatives, oryzanol and derivatives thereof as preferred.

  Examples of whitening agents include hydroquinone glycosides such as arbutin and α-arbutin and esters thereof; ascorbic acid phosphate salts such as ascorbic acid, sodium ascorbate phosphate and magnesium ascorbate phosphate, ascorbic acid Ascorbic acid fatty acid esters such as tetraisopalmitic acid ester, ascorbic acid alkyl ethers such as ascorbic acid ethyl ether, ascorbic acid glucosides such as ascorbic acid-2-glucoside and fatty acid esters thereof, 3-O-ethylascorbic acid, ascorbic acid Ascorbic acid derivatives such as sulfate ester and tocopheryl phosphate ascorbyl; kojic acid, ellagic acid, tranexamic acid and its derivatives, ferulic acid and its derivatives, placenta extract, glutathione , Oryzanol, butylresorcinol, 5,5′-dipropyl-biphenyl-2,2′-diol, 4- (4-hydroxyphenyl) -2-butanol, potassium 4-methoxysalicylate, oil-soluble chamomile extract, oil-soluble licorice Plant extracts such as extract, Nishikawayanagi extract, and Yukinoshita extract are preferred.

  Vitamins and their derivatives include vitamin A such as retinol, retinol acetate, retinol palmitate; thiamine hydrochloride, thiamine sulfate, riboflavin, riboflavin acetate, pyridoxine hydrochloride, pyridoxine dioctanoate, pyridoxine dipalmitate, Flavin adenine dinucleotide, cyanocobalamin, folic acid, nicotinic acid such as nicotinic acid amide / benzyl nicotinate, vitamin B group such as choline; vitamin C such as ascorbic acid and its sodium salt; vitamin D; α, Vitamin Es such as β, γ, δ-tocopherol; other vitamins such as pantothenic acid and biotin; ascorbic acid phosphates such as ascorbic acid phosphate sodium salt and ascorbic acid phosphate magnesium salt; Ascorbic acid fatty acid esters such as corobic acid tetraisopalmitic acid ester, ascorbyl stearate, ascorbyl palmitate and ascorbyl dipalmitate, ascorbic acid alkyl ether such as ascorbic acid ethyl ether, ascorbic acid glucoside such as ascorbic acid-2-glucoside and Ascorbic acid derivatives such as fatty acid esters and tocopheryl phosphate ascorbyl; vitamin derivatives such as tocopherol nicotinate, tocopherol acetate, tocopherol acetate, tocopherol linoleate, tocopherol phosphate, tocopherol phosphate etc., tocotrienol, and other various vitamin derivatives Is preferable.

  Anti-inflammatory and anti-inflammatory agents include glycyrrhizic acid and its derivatives, glycyrrhetinic acid derivatives, salicylic acid derivatives, hinokitiol, guaiazulene, allantoin, indomethacin, zinc oxide, hydrocortisone acetate, prednisone, diphedramine hydrochloride, chlorpheniramine maleate; peach leaf extract A plant extract such as a koji leaf extract is preferable. Plant growth and tinctures such as assembly extract, red pepper tincture, ginger tincture, ginger extract, cantalis tincture; capsaicin, nonyl acid valenylamide, gingeron, ictamol, tannic acid Borneol, cyclandelate, cinnarizine, trazoline, acetylcholine, verapamil, cephalanthin, γ-oryzanol, cephalanthin, vitamin E and nicotinic acid tocopherol, acetic acid tocopherol and other derivatives, γ-oryzanol, nicotinic acid, nicotinic acid amide, nicotinic acid benzyl Derivatives such as ester, inositol hexanicotinate, nicotine alcohol, allantoin, photosensitizer 301, photosensitizer 401, capronium chloride, pentadecanoic acid monoglyceride, Preferable examples include flavonol derivatives, stigmasterol or stigmasteranol, its glycosides, and minoxidil. Preferred hormones include estradiol, estrone, ethinyl estradiol, cortisone, hydrocortisone, prednisone and the like. Other remedies such as anti-wrinkle agents, anti-aging agents, squeeze agents, cooling sensations, warming sensation agents, wound healing promoters, irritation relievers, analgesics, cell activators include retinols, retinoic acids, retinoin Acid tocopheryl; derivatives such as lactic acid, glycolic acid, gluconic acid, fruit acid, salicylic acid and glycosides / esterified products thereof, α- or such as hydroxycapric acid, long chain α-hydroxy fatty acid, long chain α-hydroxy fatty acid cholesteryl β-hydroxy acids and derivatives thereof; γ-aminobutyric acid, γ-amino-β-hydroxybutyric acid; carnitine; carnosine; creatine; ceramides, sphingosines; caffeine, xanthine and the like; and coenzyme Q10, carotene, lycopene , Astaxanthin, lutein, α-lipoic acid, platinum nanocolloid, fullerenes, etc. Antioxidant / active oxygen scavengers; catechins; flavones such as quercetin; isoflavones; gallic acid and ester sugar derivatives; polyphenols such as tannin, sesamin, protoanthocyanidin, chlorogenic acid, apple polyphenol; rutin and glycosides, etc. Derivatives of hesperidin and glycosides; lignan glycosides; licorice extract-related substances such as grabrizine, glabrene, liquiritin, and isoliquiritin; lactoferrin; shogaol, gingerol; fragrance substances such as menthol, camphor, cedrol, and derivatives thereof Preferred examples include capsaicin, vanillin and the like and derivatives; insect repellents such as diethyltoluamide; and complexes of physiologically active substances and cyclodextrins.

  As plant / animal / microbe extracts, Iris extract, Ashitaba extract, Asunaro extract, Asparagus extract, Avocado extract, Achacha extract, Almond extract, Altea extract, Arnica extract, Aloe extract, Apricot extract, Ginkgo biloba extract, Ginkgo biloba extract , Incheon extract, Fennel extract, Turmeric extract, Oolong tea extract, Peony extract, Ages extract, Echinacea leaf extract, Enmeo extract, Ogon extract, Oat extract, Auren extract, Barley extract, Panax ginseng extract, Hypericum extract, Odori extract , Dutch mustard extract, orange extract, dried sea water, seaweed extract, oyster leaf extract, oyster extract, hydrolyzed elastin, hydrolyzed wheat powder, hydrolysis Luc, Cascon extract, Chamomile extract, Oil-soluble chamomile extract, Carrot extract, Kawara mugi extract, Oat extract, Calcade extract, Licorice extract, Oil-soluble Licorice extract, Kiwi extract, Kiou extract, Cyprid extract, Quina extract, Cucumber extract, Kiri leaf extract, Guanosine, guava extract, cucumber extract, gardenia extract, kumazasa extract, clara extract, walnut extract, chestnut extract, grapefruit extract, clematis extract, black rice extract, brown sugar extract, black vinegar, chlorella extract, mulberry extract, gentian extract, Gentian pepper extract, tea Extract, yeast extract, kokuboku extract, coffee extract, burdock extract, rice extract, rice fermented extract, rice bran fermented extract, rice germ oil, comfrey extract, Lagen, Cowberry extract, Saishin extract, Psycho extract, Saitai extract, Saffron extract, Salvia extract, Salmon extract, Sasa extract, Hawthorn extract, Sansha extract, Salamander extract, Shiitake extract, Giant extract, Shikon extract, Perilla extract, Linden extract, Shimosukeso Extract, jatoba extract, peonies extract, ginger cucumber extract, ginger root extract, white birch extract, white jellyfish extract, horsetail extract, stevia extract, stevia fermented product, west river willow extract, horse chestnut extract, hawthorn extract, elderberry extract, yarrow extract , Mint extract, sage extract, mallow extract, nematode extract, essence extract, Sakuhakuhi extract, Diou extract, Dai Extract, peanut extract, thyme extract, dandelion extract, lichen extract, tea extract, clove extract, chigaya extract, chimpi extract, tea tree oil, tea tea extract, red pepper extract, red snapper extract, red snapper extract, red spruce extract, red spruce extract, tomato Extract, natto extract, carrot extract, garlic extract, wild rose extract, hibiscus extract, bacmond extract, lotus extract, parsley extract, birch extract, honey, hamamelis extract, parietalia extract, hyacinth extract, bisabolol, cypress extract, bifidobacteria extract, Loquat extract, dandelion extract, burdock extract, bukkuri extract, butcher bloom extract, grape extract, grape seed extract, propolis, loofah extract, Safflower extract, peppermint extract, body extract, button extract, hop extract, squid extract, pine extract, maroonnier extract, mizubasho extract, mukuroji extract, melissa extract, mozuku extract, peach extract, cornflower extract, eucalyptus extract, yukinoshita extract, yuzu extract, lily extract, Yokuinin extract, mugwort extract, lavender extract, green tea extract, eggshell membrane extract, apple extract, rooibos tea extract, litchi extract, lettuce extract, lemon extract, forsythia extract, forsythia extract, rose extract, rosemary extract, roman chamomile extract, royal jelly Extracts such as an extract and a bitumen extract are preferred.

  Examples of the antipruritic agent include diphenhydramine hydrochloride, chlorpheniramine maleate, camphor, substance-P inhibitor, and the like. Examples of the exfoliating / dissolving agent include salicylic acid, sulfur, resorcin, selenium sulfide, pyridoxine and the like. Examples of the antiperspirant include chlorohydroxyaluminum, aluminum chloride, zinc oxide, and zinc paraphenol sulfonate. Examples of the refreshing agent include menthol and methyl salicylate. Examples of the astringent include citric acid, tartaric acid, lactic acid, aluminum sulfate / potassium sulfate, and tannic acid. Examples of enzymes include superoxide dismutase, catalase, lysozyme chloride, lipase, papain, pancreatin, protease, and the like. Preferred nucleic acids include ribonucleic acid and salts thereof, deoxyribonucleic acid and salts thereof, and adenosine triphosphate disodium.

  As perfumes, acetyl cedrene, amylcinnamaldehyde, allyl amyl glycolate, β-ionone, iso-Esuper, isobutyl quinoline, Iris oil, Iron, indole, ylang ylang oil, undecanal, undecenal, γ-undecalactone, Estragole, eugenol, oak moss, opoponax resinoid, orange oil, eugenol, auranthiol, galac solid, carvacrol, L-carvone, camphor, cannon, carrot seed oil, clove oil, methyl cinnamate, geraniol, geranyl nitrile , Isobornyl acetate, geranyl acetate, dimethylbenzyl carvinyl acetate, styrylyl acetate, cedolyl acetate, terpinel acetate, pt-butylcyclohexyl acetate, vetiberyl acetate, benzyl acetate, vinegar Linalyl, isopentyl salicylate, benzyl salicylate, sandalwood oil, santalol, cyclamenaldehyde, cyclopentadecanolide, methyl dihydrojasmonate, dihydromilsenol, jasmine absolute, jasmine lactone, cis-jasmon, citral, citronenol, citronellal, Cinnamon bark oil, 1,8-cineole, cinnamaldehyde, stylax resinoid, cedarwood oil, cedrene, cedrol, celery seed oil, thyme oil, damascon, damassenone, thymol, tuberose absolute, decanal, decalactone, terpineol, γ-terpinene, Tripral, Nellore, Nonanal, 2,6-Nonadienol, Nonalactone, Patchouli alcohol, Vanilla absolute , Vanillin, basil oil, patchouli oil, hydroxycitronellal, α-pinene, piperitone, phenethyl alcohol, phenylacetaldehyde, petitglen oil, hexylcinnamaldehyde, cis-3-hexenol, peruvian valsum, vetiver oil, vetiverol, peppermint oil, Pepper oil, heliotropin, bergamot oil, benzyl benzoate, borneol, milresinoid, musk ketone, methylnonylacetaldehyde, γ-methylyonone, menthol, L-menthol, L-menthol, eucalyptus oil, β-yonone, lime oil, lavender oil, Synthetic and natural fragrances such as D-limonene, linalool, rilal, rireal, lemon oil, rose absolute, rose oxide, rose oil, rosemary oil, various essential oils, and various blended fragrances It is mentioned as preferred.

As pigments / colorants / dyes / pigments, brown 201, black 401, purple 201, purple 401, blue 1, blue 2, blue 201, blue 202, blue 203, blue 204 , Blue 205, Blue 403, Blue 404, Green 201, Green 202, Green 204, Green 205, Green 3, Green 401, Green 402, Red 102, Red 104-1 , Red 105-1, Red 106, Red 2, Red 201, Red 202, Red 203, Red 204, Red 205, Red 206, Red 207, Red 208, Red 213 Red 214, Red 215, Red 218, Red 219, Red 220, Red 221, Red 223, Red 225, Red 226, Red 227, Red 228, Red 230 No. 1, Red 230-2, Red 231, Red 232, Red 3, Red 401, Red 404, Red 405, Red 501, Red 502, Red 503, Red 504, Red 505, red 506, orange 201, orange 203, orange 204, orange 205, orange 206, orange 207, orange 401, orange 402, orange 403, yellow 201, yellow 202- No. 1, yellow 202-2, yellow 203, yellow 204, yellow 205, yellow 4, yellow 401, yellow 402, yellow 403-1, yellow 404, yellow 405, yellow 406 Legal dyes such as Yellow No. 407 and Yellow No. 5; Other acidic dyes such as Acid Red 14; Base dyes such as Arianor Sienna Brown, Arianor Madder Red, Arianor Steel Blue, Arianor Straw Yellow; HC Yellow 2, HC Yellow 5, HC Red 3, 4- hydoxypropylamino-3-nitrophenol, N, N'-bis (2-hydroxyethyl) -2-nitro-p-
phenylenediamine, HC Blue 2, Basic
Nitro dyes such as Blue 26; Disperse dyes; Inorganic white pigments such as titanium dioxide and zinc oxide; Inorganic red pigments such as iron oxide (Bengara) and iron titanate; Inorganic brown pigments such as γ-iron oxide; Yellow oxidation Inorganic yellow pigments such as iron and ocher; inorganic black pigments such as black iron oxide and low-order titanium oxide; inorganic purple pigments such as mango violet and cobalt violet; inorganic such as chromium oxide, chromium hydroxide and cobalt titanate Green pigments; inorganic blue pigments such as ultramarine and bitumen; pearl pigments such as titanium oxide coated mica, titanium oxide coated bismuth oxychloride, titanium oxide coated talc, colored titanium oxide coated mica, bismuth oxychloride, fish scale foil; aluminum powder Metal powder pigments such as copper powder and gold; surface-treated inorganic and metal powder pigments; red 201, red 202, Color No. 204, Red No. 205, Red No. 220, Red No. 226, Red No. 228, Red No. 405, Orange No. 203, Orange No. 204, Yellow No. 205, Yellow No. 401, Blue No. 404, Red No. 3, Red 104 No., Red No. 106, Red No. 227, Red No. 230, Red No. 401, Red No. 505, Orange No. 205, Yellow No. 4, Yellow No. 5, Yellow No. 202, Yellow No. 203, Green No. 3, Blue No. 1, etc. Organic pigments such as zirconium, barium or aluminum lakes; surface-treated organic pigments; anthraquinones such as astaxanthin and alizarin, anthocyanidins, β-carotene, catenal, capsanthin, chalcone, calsamine, quercetin, crocin, chlorophyll, curcumin, cochineal, shikonin Naphthoquinones, bixins, flavones, betacyanidine, Natural pigments / dyes such as hemoglobin, lycopene, riboflavin, rutin; p-phenylenediamine, toluene-2,5-diamine, o-, m-, or p-aminophenol, m-phenylenediamine, 5-amino-2 -Oxidative dye intermediates and couplers such as methylphenol, resorcin, 1-naphthol, 2,6-diaminopyridine, and salts thereof; auto-oxidizing dyes such as indoline; and dihydroxyacetone are preferred.

  Preferred examples of water include normal water, purified water, hard water, soft water, natural water, deep sea water, electrolytic alkaline ionized water, electrolytic acidic ionized water, ionic water, and clustered water.

  In addition to these, cosmetic raw material standards, blending ingredient standard by cosmetic varieties, Japan Cosmetic Industry Association ingredient display name list, INCI dictionary (The International Cosmetic Ingredient Dictionary and Handbook), quasi-drug raw material standards, Japanese pharmacopoeia, pharmaceutical additives Ingredients listed in standards, official food additives, etc., and Japanese and foreign patent publications and patent publications (including publications and republications) in which the international patent classification IPC belongs to the classification of A61K7 and A61K8 It is possible to contain known cosmetic ingredients, pharmaceutical ingredients, food ingredients, etc., such as the ingredients described, in known combinations, blending ratios and blending amounts.

  Examples of the cosmetic or skin external preparation containing the hydroxynicotinic acid or derivative thereof of the present invention include hair cosmetics, basic cosmetics, makeup cosmetics, aromatic cosmetics, body cosmetics, ointments and the like. Is preferable. The cosmetic / skin external preparation of the present invention can be produced according to a usual method.

  The cosmetic or skin external preparation containing the hydroxynicotinic acid or derivative thereof according to the present invention will be described in more detail. Examples of hair cosmetics include oil shampoo, cream shampoo, conditioning shampoo, dandruff shampoo, and hair color. Shampoo, shampoo with integrated rinse, shampoo such as rinse, treatment, hair pack, hair foam, hair mousse, hair spray, hair mist, hair wax, hair gel, water grease, set lotion, color lotion, hair tonic, hair liquid, pomade, tick , Hair cream, hair blow, split hair coat, hair oil, permanent wave agent, straight permanent agent, oxidative hair dye, hair bleach, hair color pre-treatment, hair color after treatment Cement, perm pretreatment, Perm after treatments, hair manicure, and as hair growth agents are preferred.

  Basic cosmetics include soft lotion, astringent lotion, cleansing lotion, multi-layer lotion, etc .; emollient lotion, moisture lotion, milky lotion, nourishing lotion, nourishing milk, skin moisture, moisturizer -Emulsions such as emulsion, massage lotion, cleansing lotion, protect emulsion, sun protect, sun protector, UV care milk, sunscreen, makeup lotion, horny smoother, elbow lotion, hand lotion, body lotion; emollient cream, nutritional cream, nari Thing cream, burnishing cream, moisture cream, night cream, massage cream, cleansing cream, makeup cream, base cream Cream, sun makeup cream, suntan cream, hair removal cream, deodorant cream, shaving cream, keratin softening cream, etc .; gel such as moisture gel; essence such as moisturizing essence, whitening essence, UV protection essence; liposome Liposome cosmetics such as beauty essence and liposome lotion; Peel-off packs, powder packs, washing packs, oil packs, cleansing masks and other packs and masks; cleansing foams, cleansing creams, cleansing milks, cleansing lotions, cleansing gels, cleansing oils , Cleansing mask, washing powder, face washing powder, etc .; cosmetic soap, transparent soap, medicated soap, liquid soap, shaving soap, synthetic cosmetic soap Soap can be mentioned as preferred.

  Examples of makeup cosmetics that may be preferably used include white powder, dusts, foundations, lipsticks, lip gloss, blushers, eyeliner, mascara, eye shadow, eyebrow, eyebrow, nail enamel, enamel remover, and nail treatment.

  Preferred examples of the aromatic cosmetics include perfume, perfume, parfum, eau de parfum, eau de toilette, eau de cologne, perfumes, fragrance powder, perfume soap, body lotion and bath oil.

  Body cosmetics such as body shampoos; deodorant lotions, deodorant powders, deodorant sprays, deodorant sticks and other deodorant cosmetics; decoloring agents, hair removal / hair removal agents; bathing agents; insect repellents A repeller is preferred.

  Moreover, as a skin external preparation, it can be used with dosage forms, such as an ointment, a patch, a lotion agent, a liniment agent, and a liquid coating agent. It can also be used as an oral cosmetic such as toothpaste and mouthwash.

  Examples of the dosage form of a cosmetic or skin external preparation containing the hydroxynicotinic acid or derivative thereof of the present invention include an oil-in-water (O / W) type, a water-in-oil (W / O) type, a W / O / W type, O / W / O type emulsified cosmetics, oily cosmetics, solid cosmetics, liquid cosmetics, paste cosmetics, stick cosmetics, volatile oil cosmetics, powder cosmetics, jelly cosmetics Preference is given to dosage forms such as paints, gel cosmetics, paste cosmetics, emulsified polymer cosmetics, sheet cosmetics, mist cosmetics, and spray cosmetics.

  EXAMPLES Hereinafter, although this invention is demonstrated in detail using an Example, this invention is not limited to these Examples.

Synthesis Example 1 Synthesis of hydroxynicotinic acid A 2-L reactor equipped with a stirrer, a thermometer, and a gas introduction tube was charged with 220 g of 3-cyano-6-hydroxypyridine, 220 g of purified water, and 443 g of 35% hydrochloric acid at 95 to 115 ° C. The reaction was performed for 6 hours. After completion of the reaction, 630 g of purified water was added, and the precipitated crystals were separated by filtration and dried under reduced pressure at 50 ° C. to obtain 220 g (yield: 87.0%) of the target hydroxynicotinic acid.

Synthesis Example 2 Synthesis of hydroxynicotinic acid amide A 2 L reactor equipped with a stirrer, a thermometer, and a gas introduction tube was charged with 40 g of 3-cyano-6-hydroxypyridine, 680 g of 2-propanol, and 80 g of potassium hydroxide. The reflux reaction was carried out at 15 ° C. for 15 hours. After completion of the reaction, 360 g of purified water was added and the two layers were separated with a separatory funnel. The obtained upper layer was neutralized with 35% hydrochloric acid, and the precipitated crystals were separated by filtration and dried under reduced pressure at 50 ° C. to obtain 21.1 g (yield 45.9%) of the desired product, hydroxynicotinic acid amide. It was.

The structures of the compounds obtained in Synthesis Examples 1 and 2 were identified by nuclear magnetic resonance spectrum (apparatus: JNM-AL, 300 MHz, JEOL Ltd., measurement: ¹ H-NMR, solvent: DMSO). The results are shown in Tables 1 and 2. The structural formula of the compound obtained in Synthesis Example 1 is shown in Chemical Formula 7, the structural formula of the compound obtained in Synthetic Example 2 is shown in Chemical Formula 8, and the ¹ H-NMR assignment number is also shown in the formula.

Whitening evaluation 1 Whitening evaluation using a three-dimensional skin model The hydroxynicotinic acid amide synthesized in Synthesis Example 2 was examined for whitening action using a melanocyte-containing human three-dimensional skin model. Nicotinamide was used as a comparative control. The measurement method was as follows, and the results are shown in Table 3.
(Measuring method)
50 μL of the aqueous solution (concentration: 0.6 w / v%, 0.4 w / v%, 0.2 w / v%) of the test sample is added to the surface of the skin model on a melanocyte-containing human three-dimensional skin model (MEL-300B, manufactured by Kurabo Industries) (The stratum corneum side) was added and cultured in a CO ₂ incubator (5% CO ₂ , 37 ° C.). Thereafter, the medium was changed and the sample was added every 1 to 2 days and cultured for 14 days. Thereafter, the degree of blackness of the skin model was visually evaluated. In addition, the cultured skin model membrane is cut out from the culture cup, washed 3 times with phosphate buffer, and then 3N
Melanin content was measured by dissolving using sodium hydroxide and measuring absorbance (405 nm) using a microplate reader. In addition, the amount of melanin was shown by the relative value when what added the test sample (control) was set to 100.

  From the results in Table 3, the nicotinic acid amide used as a comparison showed a whitening effect only at a high concentration and did not show a whitening effect at a low concentration. On the other hand, it was found that hydroxynicotinic acid amide, which is a hydroxynicotinic acid derivative of the present invention, showed a whitening effect even at a low concentration, and had a whitening effect superior to nicotinic acid amide.

Whitening Evaluation 2 Whitening Evaluation Using Cultured B16 Melanoma Cells Hydroxynicotinic acid and hydroxynicotinic acid amide synthesized in Synthesis Examples 1 and 2 were examined for melanin production inhibitory effect using B16 melanoma cultured cells derived from mice. The measurement method was as follows, and the results are shown in Table 4.

(Measuring method)
After suspending mouse-derived B16 melanoma cultured cells in D-MEM medium containing 2 mM theophylline and 10% FBS, 2 × 10 ⁴ cells were seeded per well in a 12-well cell culture plate, and a CO ₂ incubator (95% The cells were cultured for 24 hours at 37 ° C. in air and 5% carbon dioxide. Thereafter, the test sample was replaced with a medium in which the test sample was dissolved in advance (the sample concentration in the medium was 0.1 w / v%), and the culture was further continued for 3 days. The medium was then removed, washed with phosphate buffer, the cells were lysed with 1N sodium hydroxide solution, and the melanin content was measured by measuring the absorbance at 405 nm. When the amount of melanin when the test sample was added was X and the amount of melanin when the test sample was not added was Y, the melanin production inhibition rate was calculated by the following formula.

Melanin production inhibition rate (%) = (1−X / Y) × 100

  From the results of Table 4, it was found that the hydroxynicotinic acid and hydroxynicotinic acid amide of the present invention have the same excellent whitening effect.

Example 1 Emulsion An emulsion having the following formulation was prepared. This emulsion showed an appropriate viscosity, was excellent in spreading, and was excellent in use feeling.

Component Blending amount (% by weight)
--------------------------------------
Part A cetanol 0.20
Squalane 0.05
Soybean oil 0.05
Behenez-30 0.05
Ethylhexyl methoxycinnamate 0.05
Tocopherol 0.05
Part B stearoxyhydroxypropylmethylcellulose 0.40
Purified water 20.00
Part C Hydroxynicotinamide 0.50
Hydroxyethyl ethylenediamine triacetate 0.01
Hyaluronic acid Na 0.03
Sorbitol 6.00
Succinic acid 0.03
Sodium succinate proper amount diglycerin 0.15
Apple polyphenol 0.02
Phenoxyethanol 0.20
Methylparaben 0.15
Purified water Total amount of 100 --------------------------------------
(Preparation method)
Part A was heated to about 70 ° C. and dissolved uniformly. Part B was stirred to obtain a viscous liquid. Add part C heated to about 70 ° C. to part A, stir to emulsify, then cool and add part B at about 50 ° C., stir to dissolve uniformly, and pH 6.0 with Na succinate. did.

Example 2 Cream A cream having the following formulation was prepared. This cream showed an appropriate viscosity, was excellent in spreading, and was excellent in use feeling.

Component Blending amount (% by weight)
--------------------------------------
Part A batyl alcohol 2.00
Squalane 2.00
Glyceryl tri-2-ethylhexanoate 3.00
Stearic acid 1.00
Macadamia nut oil fatty acid phytosteryl 1.00
Natural vitamin E 0.05
Behenyl alcohol 2.00
Lipophilic glyceryl monostearate1.00
Ethylparaben 0.15
Methyl polysiloxane 0.50
Polyoxyethylene cetyl ether 2.00
Phytocompo-PP (Nippon Seika) 0.50
Part B (acryloyldimethyltaurate ammonium /
Methenic acid behenes-25) Cross polymer 0.20
Purified water 20.00
Part C Hydroxynicotinamide 2.00
Succinic acid 0.01
Sodium succinate proper amount 1,3-butylene glycol 0.15
Hydrolyzed collagen 0.20
Hydroxyethane diphosphonic acid solution 0.03
Concentrated glycerin 0.20
Methylparaben 0.10
Purified water Total amount of 100 --------------------------------------
(Preparation method)
Part A was heated to about 70 ° C. and dissolved uniformly. Part B was stirred to obtain a viscous liquid. Part C was heated to about 70 ° C. and dissolved uniformly. C part was added to A part, stirred and emulsified and then cooled. Part B was added at about 50 ° C. and stirred to dissolve uniformly, and the pH was adjusted to 6.0 with Na succinate.

Example 3 Emulsion An emulsion having the following formulation was prepared. This emulsion showed an appropriate viscosity, was excellent in spreading, and was excellent in use feeling.

Component Blending amount (% by weight)
--------------------------------------
Part A sorbitan stearate 0.50
PEG-10 stearate 0.50
Polysorbate 60 0.50
Cetyl octanoate 3.70
Cetanol 1.20
Dimethicone (10cs) 1.00
Ethylparaben 0.10
Part B (acryloyldimethyltaurate ammonium / VP) copolymer 0.05
Stearoxyhydroxypropylmethylcellulose 0.10
Xanthan gum 0.10
Carbomer 0.15
Hydroxide K 0.06
Purified water 20.00
Part C Hydroxynicotinamide 0.50
1,3-butylene glycol 3.00
Cyclohexanedicarboxylic acid bisethoxydiglycol 1.00
Glycerin 1.00
Phenoxyethanol 0.20
Methylparaben 0.15
Phytic acid 0.50
Citric acid 0.01
Na citrate 0.09
Purified water Total amount of 100 --------------------------------------
(Preparation method)
Part A was heated to about 70 ° C. and dissolved uniformly. Part B was stirred to obtain a viscous liquid. Part C was heated to about 70 ° C. and dissolved uniformly. C part was added to part A, emulsified with a homomixer and then cooled. Part B was added at about 50 ° C., stirred and dissolved uniformly, and adjusted to pH 6.0 with sodium citrate.

Example 4 Lotion Toner lotion having the following formulation was prepared. This lotion was excellent in use feeling and moisturizing feeling.

Component Blending amount (% by weight)
--------------------------------------
Part A xanthan gum 0.30
Carbomer 0.20
Tremoist-TP (Nippon Seika) 0.20
Purified water 20.00
Part B (eicosanedioic acid / tetradecanedioic acid) polyglyceryl 1.00
BG 1.00
Glycerin 2.00
Ubiquinone 0.03
IOTG (Japan Seika) 0.03
Tetraoleic acid Solves-60 0.12
PEG-60 hydrogenated castor oil 0.03
PEG-30 glyceryl isostearate 0.03
Methylparaben 0.20
Fragrance Trace amount ethanol 7.00
Part C Hydroxynicotinamide 0.50
Ascorbic acid 2-glucoside 2.00
Citric acid 0.01
Sodium citrate appropriate amount glutamic acid diacetate 4Na 0.80
Purified water Total amount of 100 --------------------------------------
(Preparation method)
Part A was stirred to obtain a viscous liquid. Part B was heated to about 70 ° C. and dissolved uniformly. Part B was added to part C at about 50 ° C. and stirred to dissolve uniformly. Further, part A was added and stirred to dissolve uniformly, and the pH was adjusted to 7.0 with sodium citrate.

Example 5 Lotion Toner lotion having the following formulation was prepared. This lotion was excellent in use feeling and moisturizing feeling.

Component Blending amount (% by weight)
--------------------------------------
Part A Glycerin 2.00
Methylparaben 0.10
Phenoxyethanol 0.20
Ethanol 5.00
B part hydroxynicotinic acid amide 0.50
Arbutin 3.00
Glycine 0.20
BG 2.00
Polyethylene glycol 1500 2.00
Polyglutamic acid solution 1.00
Anhydrous sodium sulfite 0.20
Citric acid 0.01
Sodium citrate appropriate amount edetic acid 3Na 0.10
Purified water Total amount of 100 --------------------------------------
(Preparation method)
A part and B part were stirred and dissolved uniformly. Next, part B was added to part A, stirred and dissolved uniformly, and adjusted to pH 5.0 with sodium citrate.

Example 6 Lotion Toner lotion having the following formulation was prepared. This lotion was excellent in use feeling and moisturizing feeling.

Component Blending amount (% by weight)
--------------------------------------
Part A stearoxyhydroxypropyl methylcellulose 0.60
Tremoist-TP (Nippon Seika) 0.20
Purified water 20.00
B part hydroxynicotinic acid amide 0.50
Ascorbyl ethyl (Nippon Seika) 1.00
Ethanol 7.00
BG 7.00
Glycerin 5.00
Methylparaben 0.10
Phenoxyethanol 0.20
Citric acid 0.10
Sodium citrate appropriate amount Penteto acid 5Na 0.10
Purified water Total amount of 100 --------------------------------------

(Preparation method)
Part A was stirred to obtain a viscous liquid. Part B was heated to about 70 ° C. and dissolved uniformly. Part A was added to part B at about 50 ° C., and the mixture was stirred and dissolved uniformly. The pH was adjusted to 4.0 with Na citrate.

Example 7 Whitening Gel A whitening gel having the following formulation was prepared. This whitening gel exhibited a moderate viscosity, was excellent in spreading, and had a penetrating feeling.

Component Blending amount (% by weight)
--------------------------------------
Part A ethanol 5.00
Ethyl hexyl methoxycinnamate 0.01
BHT 0.01
1,3-butylene glycol 6.00
Glycerin 1.00
Phenoxyethanol 0.20
Methylparaben 0.15
Part B (acryloyldimethyltauronium ammonium / VP) copolymer 1.00
Purified water 20.00
Part C hydroxynicotinic acid 1.00
Hydrolyzed yeast extract 0.05
Hydroxyproline 0.20
Pentethic acid (diethylenetriaminepentaacetic acid) 0.06
Citric acid 0.05
Na citrate Suitable amount Purified water Total amount to be 100-------------------------------- −
(Preparation method)
Part A was mixed and dissolved uniformly. Part B was mixed and stirred to give a viscous liquid. Part C was mixed and dissolved uniformly. C part and A part were added to B part, stirred and dissolved uniformly.

Example 8 Whitening Gel A whitening gel having the following formulation was prepared. This whitening gel exhibited a moderate viscosity, was excellent in spreading, and had a penetrating feeling.

Component Blending amount (% by weight)
--------------------------------------
Part A Sorbitol 6.00
Diglycerin 1.00
Phytopresome-Q10 (Nippon Seika) 0.30
Part B (acryloyldimethyltaurine / methacrylic acid
Behenez-25) copolymer 0.20
Stearoxyhydroxypropylmethylcellulose 0.80
Tremoist-TP (Nihon Seika) 0.03
Purified water 20.00
Part C Hydroxynicotinamide 0.20
Olive leaf extract 0.05
Maronier extract 0.05
Glycosyl trehalose 0.05
Fumaric acid 0.05
Fumarate Na proper amount HEDTA-3Na (hydroxyethylethylenediaminetriacetic acid) 0.15
Warmoko extract 0.20
Phenoxyethanol 0.20
Methylparaben 0.15
Purified water Total amount of 100 --------------------------------------
(Preparation method)
Part A was mixed and heated to about 70 ° C. to dissolve evenly. Part B was mixed and stirred to give a viscous liquid. Part C was mixed and heated to about 70 ° C. and dissolved uniformly. Part C was added to part B, stirred with a homomixer, uniformly dissolved, cooled, and part A was added at about 50 ° C., and stirred to dissolve uniformly.

Example 9 Whitening emulsion A whitening emulsion having the following formulation was prepared. This whitening emulsion showed moderate viscosity, was excellent in spreading, and had a penetrating feeling.

Component Blending amount (% by weight)
--------------------------------------
Part A cetanol 0.20
Squalane 0.05
Soybean oil 0.05
Behenez-30 0.05
Ethylhexyl methoxycinnamate 0.05
Tocopherol 0.05
Part B stearoxyhydroxypropylmethylcellulose 0.40
Purified water 20.00
Part C Hydroxynicotinamide 0.50
Purified water 5.00
Part D HEDTA-3Na (hydroxyethylethylenediaminetriacetic acid) 0.01
Hyaluronic acid Na 0.03
Sorbitol 6.00
Succinic acid 0.03
Sodium succinate proper amount diglycerin 0.15
Sohakuhi extract 0.20
Loquat leaf extract 0.15
Phenoxyethanol 0.20
Methylparaben 0.15
Purified water Total amount of 100 --------------------------------------
(Preparation method)
Part A was mixed and heated to about 70 ° C. to dissolve evenly. Part B was mixed and stirred to give a viscous liquid. Part C was mixed and dissolved uniformly. Part D was mixed and heated to about 70 ° C. and dissolved uniformly. After adding D part to A part and stirring and emulsifying, it cooled and added about C and B part at about 50 degreeC, and it stirred and melt | dissolved uniformly.

Example 10 Whitening Cream A whitening cream having the following formulation was prepared. This whitening cream showed moderate viscosity, was excellent in spreading, and had a penetrating feeling.

Component Blending amount (% by weight)
--------------------------------------
Part A batyl alcohol 2.00
Squalane 2.00
Glyceryl tri-2-ethylhexanoate 3.00
Stearic acid 1.00
Macadamia nut oil fatty acid phytosteryl 1.00
Natural vitamin E 0.05
Behenyl alcohol 2.00
Lipophilic glyceryl monostearate1.00
Ethylparaben 0.15
Methyl polysiloxane 0.50
Polyoxyethylene cetyl ether 2.00
Phytocompo-PP (Nippon Seika) 0.50
Part B (acryloyldimethyltaurine / methacrylic acid
Behenez-25) copolymer 0.20
Purified water 20.00
Part C Hydroxynicotinamide 5.00
Purified water 25.00
Part D Succinic acid 0.01
Sodium succinate proper amount 1,3-butylene glycol 0.15
Sohakuhi extract 0.20
Hydroxyethane diphosphonic acid solution (60%) 0.10
Concentrated glycerin 0.20
Methylparaben 0.10
Purified water Total amount of 100 --------------------------------------
(Preparation method)
Part A was mixed and heated to about 70 ° C. to dissolve evenly. Part B was mixed and stirred to give a viscous liquid. Part C was mixed and dissolved uniformly. Part D was mixed and heated to about 70 ° C. and dissolved uniformly. After adding D part to A part and stirring and emulsifying, it cooled and added about C and B part at about 50 degreeC, and it stirred and melt | dissolved uniformly.

Example 11 Whitening Cream A whitening cream having the following formulation was prepared. This whitening cream showed moderate viscosity, was excellent in spreading, and had a penetrating feeling.

Component Blending amount (% by weight)
--------------------------------------
Part A jojoba oil 2.00
Plandool-H (Nippon Seika) 1.00
PEG-60 glyceryl isostearate 0.70
Macadamia nut oil fatty acid phytosteryl 1.00
Propylene glycol monostearate 0.60
Behenyl alcohol 1.20
Self-emulsifying glyceryl monostearate 1.20
Ethylparaben 0.15
Methylpolysiloxane 1.00
Polyoxyethylene cetyl ether 2.00
Part B stearoxyhydroxypropyl methylcellulose 0.20
(Acryloyldimethyltaurine / methacrylic acid
Behenez-25) copolymer 0.30
Purified water 20.00
Part C Hydroxynicotinamide 2.00
Purified water 5.00
D part quince seed extract 0.05
Citric acid 0.07
Sodium citrate appropriate amount 1,3-butylene glycol 0.15
Sohakuhi extract 0.20
Ethylenediaminetetraacetic acid disodium salt 0.10
Concentrated glycerin 2.00
Methylparaben 0.10
Purified water Total amount of 100 --------------------------------------
(Preparation method)
Part A was mixed and heated to about 70 ° C. to dissolve evenly. Part B was mixed and stirred to give a viscous liquid. Part C was mixed and dissolved uniformly. Part D was mixed and heated to about 70 ° C. and dissolved uniformly. After adding D part to A part and stirring and emulsifying, it cooled and added about C and B part at about 50 degreeC, and it stirred and melt | dissolved uniformly.

Example 12 Emollient Cream An emollient cream having the following formulation was prepared. This whitening emollient cream was an emollient cream having an appropriate viscosity, excellent spread and a penetrating feeling.

Component Blending amount (% by weight)
--------------------------------------
Part A hydrogenated palm oil 2.50
Behenyl alcohol 2.00
Dimethicone (10cs) 1.50
Glyceryl stearate 1.50
Stearyl alcohol 1.20
Stearic acid PG (SE) 1.00
PEG-60 glyceryl isostearate 1.00
Ethyl hexyl methoxycinnamate 0.20
Ethylparaben 0.10
Part B (acryloyldimethyltaurate ammonium / VP) copolymer 0.30
(Acryloyldimethyltaurine / methacrylic acid
Behenez-25) copolymer 0.30
Purified water 20.00
Part C hydroxynicotinic acid amide 1.00
Purified water 5.00
Part D 1,3-butylene glycol 6.00
Ethylenediamine disuccinic acid 3Na 0.30
Pentethic acid (diethylenetriaminepentaacetic acid) 0.05
Fumaric acid 0.05
Sodium fumarate appropriate amount glycerol 1.00
Phenoxyethanol 0.20
Methylparaben 0.15
Purified water Total amount of 100 --------------------------------------
(Preparation method)
Part A was mixed and heated to about 70 ° C. to dissolve evenly. Part B was mixed and stirred to give a viscous liquid. Part C was mixed and dissolved uniformly. Part D was mixed and heated to about 70 ° C. and dissolved uniformly. After adding D part to A part and emulsifying with a homomixer, it cooled and added about C part and B part at about 50 degreeC, and it stirred and melt | dissolved uniformly.

Example 13 Sunscreen Agent A sunscreen agent having the following formulation was prepared. This whitening sunscreen exhibited a moderate viscosity, was excellent in spreading, and had a good UV protection ability.

Component Blending amount (% by weight)
--------------------------------------
Part A squalane 22.50
LUSPLAN PI-DA (Nippon Seika) 2.70
Microcrystalline wax 2.70
Distearate Al 1.60
Mg stearate 1.60
1,3-butylene glycol 5.00
Behenyl alcohol 4.80
Composite-PC (Nippon Seika) 1.00
Cholesterol 0.80
Propylparaben 0.20
Part B (acryloyldimethyltaurine / methacrylic acid
Behenez-25) copolymer 0.30
Purified water 20.00
Part C hydroxynicotinic acid 0.20
Pentethic acid (diethylenetriaminepentaacetic acid) 0.10
Succinic acid 0.05
Sodium succinate appropriate amount purified water 5.00
D part methyl paraben 0.20
Titanium oxide 9.00
Mg sulfate 0.50
Purified water Total amount of 100 --------------------------------------
(Preparation method)
Part A was added and kneaded with a mill. Part B was added to another container and heated to about 150 ° C. and dissolved. Part C was added to another container and heated to about 80 ° C. and dissolved. Part D was added to a separate container and heated to about 80 ° C. and dissolved. Part C was added to part B, mixed, and then added to part A and mixed uniformly. Subsequently, D part was added, it stirred, and it cooled to 40 degreeC after emulsification.

Example 14 Base Cream A base cream having the following formulation was prepared. The whitening base cream was a base cream having an appropriate viscosity, excellent spreading, and covering power.

Component Blending amount (% by weight)
--------------------------------------
Part A cyclomethicone 15.00
Trimethylsiloxysilicate 3.00
Glyceryl stearate (SE) 2.00
Stearic acid PG (SE) 2.00
Macadamia nut fatty acid phytosteryl 2.00
Stearic acid 0.50
Palmitic acid 0.50
Ethyl hexyl methoxycinnamate 0.50
Tocopherol 0.20
Part B stearoxyhydroxypropylmethylcellulose 0.10
Purified water 20.00
Part C hydroxynicotinic acid 0.80
Glutamic acid diacetate 4Na 0.80
Pentethic acid (diethylenetriaminepentaacetic acid) 0.05
Lactic acid 0.05
Lactic acid Na appropriate amount purified water 5.00
Part D 1,3-butylene glycol 10.00
Mica 8.00
Talc 7.00
Phenoxyethanol 0.80
Titanate (Li / Cobalt) 0.20
Xanthan gum (10%) 2.00
Cellulose gum (10%) 2.00
Purified water Total amount of 100 --------------------------------------
(Preparation method)
Part A was mixed and heated to about 70 ° C. to dissolve evenly. Part B was mixed and stirred to give a viscous liquid. Part C was mixed and dissolved uniformly. Part D was mixed and heated to about 70 ° C. and dissolved uniformly. After adding D part to A part and emulsifying with a homomixer, it cooled and added C part and B part at about 50 degreeC, and it stirred and melt | dissolved uniformly.

Example 15 Massage Cream A whitening massage cream having the following formulation was prepared. This massage cream was a massage cream having a high massage effect, an appropriate viscosity, excellent spreading, and a moisturizing feeling.

Component Blending amount (% by weight)
--------------------------------------
Part A macadamia nut fatty acid phytosteryl 8.00
Glyceryl stearate (SE) 2.00
Polysorbate 60 1.80
Sorbitan stearate 1.00
Polyglyceryl stearate-10 0.50
Cholesterol 0.20
Dimethicone (10cs) 1.00
Myristyl alcohol 1.00
Stearic acid 1.00
Stearyl alcohol 0.50
Behenyl alcohol 0.50
Hydrogenated palm oil 9.00
Tocopherol 0.10
Isostearyl palmitate 2.00
Cetyl ethylhexanoate 15.00
Ethylparaben 0.20
Part B (acryloyldimethyltaurate ammonium / VP) copolymer 0.30
Purified water 20.00
Part C Hydroxynicotinamide 0.40
Purified water 5.00
D part phenoxyethanol 0.20
Methylparaben 0.10
HEDTA-3Na (hydroxyethylethylenediaminetriacetic acid) 0.20
Fumaric acid 0.05
Sodium fumarate appropriate amount 1,3-butylene glycol 10.00
Glycerin 3.00
Purified water Total amount of 100 --------------------------------------
(Preparation method)
Part A was mixed and heated to about 70 ° C. to dissolve evenly. Part B was mixed and stirred to give a viscous liquid. Part C was mixed and dissolved uniformly. Part D was mixed and heated to about 70 ° C. and dissolved uniformly. After adding D part to A part and emulsifying with a homomixer, it cooled and added C part and B part at about 50 degreeC, and it stirred and melt | dissolved uniformly.

Example 16 Whitening emulsion A whitening emulsion having the following formulation was prepared. This whitening emulsion showed moderate viscosity, was excellent in spreading, and had a penetrating feeling.

Component Blending amount (% by weight)
--------------------------------------
Part A sorbitan stearate 0.50
PEG-10 stearate 0.50
Polysorbate 60 0.50
Cetyl ethylhexanoate 3.70
Cetanol 1.20
Dimethicone (10cs) 1.00
1,2-hexanediol / caprylyl glycol 0.50
Ethylparaben 0.10
Part B (acryloyldimethyltaurate ammonium / VP) copolymer 0.05
Stearoxyhydroxypropylmethylcellulose 0.10
Purified water 20.00
Part C 3-O-ethylascorbic acid 1.00
Hydroxynicotinamide 0.50
Purified water 5.00
Part D 1,3-butylene glycol 3.00
(Eicosandioic acid / tetradecanedioic acid) polyglyceryl-10 1.00
Glycerin 1.00
Phenoxyethanol 0.20
Methylparaben 0.15
Hydroxyethane diphosphonic acid solution (60%) 0.05
Phytic acid 0.50
Citric acid 0.01
Na citrate 0.09
Xanthan gum 0.10
Carbomer 0.15
Hydroxide K 0.06
Purified water Total amount of 100 --------------------------------------
(Preparation method)
Part A was mixed and heated to about 70 ° C. to dissolve evenly. Part B was mixed and stirred to give a viscous liquid. Part C was mixed and dissolved uniformly. Part D was mixed and heated to about 70 ° C. and dissolved uniformly. After adding D part to A part and emulsifying with a homomixer, it cooled and added C part and B part at about 50 degreeC, and it stirred and melt | dissolved uniformly.

Example 17 Liquid Foundation A whitening liquid foundation having the following formulation was prepared. This whitening liquid foundation was excellent in feeling of use and adhesion to the skin, showed an appropriate viscosity, and was excellent in spreading.

Component Blending amount (% by weight)
--------------------------------------
Part A Glyceryl stearate (SE) 1.00
Stearic acid PG (SE) 1.00
Cetyl octanoate 6.00
Tocopherol 0.10
Propylparaben 0.10
Titanium oxide / iron oxide mixture 18.00
(Toyo Pigment Co., Ltd. FDP-W-007)
Mica 7.00
Trimethylsiloxysilicate 3.00
Cyclomethicone 7.00
Phenylmethicone 5.00
Part B (acryloyldimethyltaurate ammonium / VP) copolymer 0.20
Stearoxyhydroxypropylmethylcellulose 0.05
(Acryloyldimethyltaurine / methacrylic acid
Behenez-25) copolymer 0.15
Purified water 20.00
Part C Hydroxynicotinamide 0.10
Succinic acid 0.05
Sodium succinate appropriate amount purified water 5.00
Part D Cellulose Gum 0.10
Xanthan gum 0.20
Hydroxyethane diphosphonic acid solution (60%) 0.05
Glutamic acid diacetate 4Na 1.20
1,3-butylene glycol 5.00
Pentylene glycol 3.00
Methylparaben 0.05
Purified water Total amount of 100 --------------------------------------
(Preparation method)
Part A was mixed and heated to about 70 ° C. to dissolve evenly. Part B was mixed and stirred to give a viscous liquid. Part C was mixed and dissolved uniformly. Part D was mixed and heated to about 70 ° C. and dissolved uniformly. After adding D part to A part and emulsifying with a homomixer, it cooled and added C part and B part at about 50 degreeC, and it stirred and melt | dissolved uniformly.

Example 18 Whitening Anti-Aging Cream A whitening anti-aging cream having the following formulation was prepared. This whitening cream was a cream with good elongation and excellent moisturizing effect, an appropriate viscosity, excellent spread, and a penetrating cream.

Component Blending amount (% by weight)
---------------------------------------
Part A Ethyl Hexanoate Cetyl 7.00
Batyl isostearate 2.00
PEG-60 glyceryl isostearate 1.50
Hydrogenated palm oil 3.70
Ceramide 2 0.10
Retinol 0.10
Oil-soluble chamomile extract 0.10
Ethylparaben 0.20
Stearyl alcohol 3.50
Glyceryl stearate (SE) 1.00
Steerless-6 1.50
Distearic acid PEG-8 1.00
Cetanol 1.00
Dimethicone 1.00
Cetyl dimethicone copolyol 0.50
Tocopherol 0.20
Part B (acryloyldimethyltaurate ammonium / VP) copolymer 0.10
Stearoxyhydroxypropylmethylcellulose 0.05
(Acryloyldimethyltaurine / methacrylic acid
Behenez-25) copolymer 0.15
Purified water 20.00
Part C Nishikawayanagi Extract 0.05
Hydroxynicotinamide 3.00
Purified water 9.00
D part arbutin 0.50
Ascorbic acid 2-O-glucoside 0.50
EDTA-3Na 0.10
Polyglutamic acid (Ichimaru Falcos, Bio PGA solution) 0.10
(Eicosandioic acid / tetradecanedioic acid) polyglyceryl-10 1.00
Glycerin 4.00
Bisulfite Na 0.05
Lactic acid 0.05
Lactic acid Na proper amount Na propionate 0.02
Methylparaben 0.05
Phenoxyethanol 0.10
BG 6.00
Purified water Total amount of 100 ---------------------------------------
(Production method)
Part A was heated to about 80 ° C. and dissolved uniformly. Part B was mixed and stirred to give a viscous liquid. Part C was mixed and dissolved uniformly. Part D was heated to about 80 ° C. and dissolved. While stirring with a homomixer at about 80 ° C., part A was gradually added, mixed uniformly after emulsification, cooled to about 40 ° C., and parts B and C were added and mixed uniformly.

Example 19 Sunscreen Cosmetic A whitening sunscreen cosmetic having the following formulation was prepared. This whitening sunscreen cosmetic did not float white and had a high UV protection effect. Furthermore, it was a sunscreen having an appropriate viscosity and excellent in stretching.

Component Blending amount (% by weight)
--------------------------------------
Part A quaternium-18 hectorite 1.00
Part B cyclomethicone 13.70
Diphenyl dimethicone 7.00
Dimethicone copolyol 5.50
YOFCO MAS (Nippon Seika) 1.00
Part C silicone-treated fine particle titanium oxide 3.90
Silicone-treated zinc oxide 2.10
D part Al stearate 0.70
Hydroxide Al 0.50
Isononyl isononanoate 2.50
Isodecyl neopentanoate 2.50
Part E Trimethylsiloxysilicate 1.20
Dimethicone 0.80
Meticon 0.10
Stearyl glycyrrhetinate 0.02
Sorbitan sesquioleate 2.00
Tocopherol 0.02
Part F hydroxynicotinamide 0.70
(Acryloyldimethyltaurate ammonium / VP) copolymer 0.30
Na chloride 1.00
Hydroxyethane diphosphonic acid solution (60%) 0.07
Lactic acid 0.05
Lactic acid Na Appropriate amount Isopropylmethylphenol 0.05
EDTA-3Na 0.10
Methylparaben 0.15
Purified water Total amount of 100 --------------------------------------
(Production method)
Add Part A to Part B and stir. Add part C and disperse using a roller mill. Part D is heated and melted and added to the mixture of Part A, Part B, Part C, and Part E is added to about 70 ° C. Part F is heated and gradually emulsified with stirring into the mixture from Part A to Part E. The mixture was cooled while stirring and stopped at 40 to 35 ° C.

Example 20 Bath agent (bubble bath)
A whitening bath preparation having the following formulation was prepared. This whitening bath agent had effects such as moisturizing skin and improving skin gloss.

Component Blending amount (% by weight)
--------------------------------------
Part A (C12, 13) Palace-3 sulfate Na 5.00
Cocamide DEA 2.00
Sulfosuccinic acid (C12-14) Palace-2Na 2.00
1,3-butylene glycol 2.00
PEG-20 glyceryl triisostearate 1.00
Part B stearoxyhydroxypropyl methylcellulose 0.20
(Acryloyldimethyltaurine / methacrylic acid
Behenez-25) copolymer 0.30
Purified water 20.00
Part C hydroxynicotinic acid amide 1.00
Citric acid 0.05
Sodium citrate appropriate amount hydroxyethane diphosphonic acid solution (60%) 0.05
Ethylenediamine disuccinic acid 3Na 2.00
Sodium benzoate 0.20
Blue No. 1 Trace yellow No. 4 Trace D part Purified water Amount to be 100 in total ------------------------------ --------
(Production method)
Part A is dissolved in part D to make it uniform. Part B was added and stirred to give a viscous liquid. The remaining D part, B part and C part were added and kneaded well.

Example 21 Whitening moisturizing lotion The following whitening moisturizing lotion was prepared. This whitening moisturizing lotion was excellent in the feeling of use and moisturizing, kept the skin soft and fresh, smooth and moist, and these effects lasted for a long time.

Component Blending amount (% by weight)
--------------------------------------
Part A (acryloyldimethyltaurate ammonium / VP) copolymer 0.30
Stearoxyhydroxypropylmethylcellulose 0.20
Purified water 20.00
Part B hydroxynicotinic acid amide 1.50
Purified water 5.00
Part C (eicosanedioic acid / tetradecanedioic acid) polyglyceryl-10 1.00
BG 1.00
Glycerin 2.00
Citric acid 0.01
Sodium citrate appropriate amount ubiquinone 0.03
IOTG (Japan Seika) 0.03
Tetraoleic acid Solves-60 0.12
PEG-60 hydrogenated castor oil 0.03
PEG-30 glyceryl isostearate 0.03
Hydroxyethane diphosphonic acid solution (60%) 0.03
Methylparaben 0.20
Fragrance Trace amount ethanol 7.00
Triclosan 0.05
Glutamic acid diacetate 4Na 0.80
Purified water Total amount of 100 --------------------------------------
(Preparation method)
Part A was mixed and stirred to give a viscous liquid. Part B was mixed and dissolved uniformly. Part C was mixed and heated to about 70 ° C. and dissolved uniformly. Cooled and added parts A and B to part C at about 50 ° C. and stirred to dissolve uniformly.

Example 22 Hand Cream A whitening hand cream having the following formulation was prepared. This whitening hand cream was non-sticky and water-repellent hand cream. Moreover, it was a hand cream which showed moderate viscosity and was excellent in spreading.

Component Blending amount (% by weight)
--------------------------------------
Part A Plandool-G (Nippon Seika) 0.30
Silwax S (Nippon Seika) 4.00
Hydrogenated lecithin 1.00
Behenyl alcohol 2.50
CIO (Nippon Seika) 3.00
Propylparaben 0.20
Dimethicone 4.00
Part B stearoxyhydroxypropyl methylcellulose 0.20
(Acryloyldimethyltaurine / methacrylic acid
Behenez-25) copolymer 0.50
Purified water 20.00
Part C hydroxynicotinic acid amide 0.30
Purified water 5.00
Part D BG 5.00
Methylparaben 0.20
Butylcarbamate propynyl iodide 0.02
Ethylenediaminetetraacetic acid 0.10
Xanthan gum (2% aqueous solution) 15.00
Fumaric acid 0.01
Sodium fumarate Appropriate amount Purified water Total amount of 100 ----------------------------- −
(Preparation method)
Part A was mixed and heated to about 70 ° C. to dissolve evenly. Part B was mixed and stirred to give a viscous liquid. Part C was mixed and dissolved uniformly. Part D was mixed and heated to about 70 ° C. and dissolved uniformly. After adding D part to A part and emulsifying with a homomixer, it cooled and added C part and B part at about 50 degreeC, and it stirred and melt | dissolved uniformly.

Example 23 Pre-shave lotion A whitening pre-shave lotion having the following formulation was prepared. This pre-shave lotion has the effect of making the skin smooth. Furthermore, it was a pre-shave lotion exhibiting an appropriate viscosity and excellent in spreading.

Component Blending amount (% by weight)
--------------------------------------
Part A hydroxynicotinic acid amide 0.60
Citric acid 0.05
Zinc phenol sulfonate 0.20
Stearoxyhydroxypropylmethylcellulose 0.10
(Acryloyldimethyltaurine / methacrylic acid
Behenez-25) copolymer 0.10
PEG-60 hydrogenated castor oil 0.10
Ethylenediaminetetraacetic acid disodium salt 0.10
Glycyrrhizic acid 2K 0.05
Succinic acid 0.05
Sodium succinate Appropriate amount of purified water Total amount of 100 parts B ethanol 30.00
Tocopherol 0.01
Triclocarban 0.02
Methylparaben 0.15
--------------------------------------
(Preparation method)
Both part A and part B were dissolved at room temperature, and part B was gradually added to part A while stirring to make it uniform.

Example 24 After Shave Lotion A whitening after shave lotion having the following formulation was prepared. This after-shave lotion was an after-shave lotion having an appropriate viscosity, excellent in spreading and refreshing feeling.

Component Blending amount (% by weight)
--------------------------------------
Part A hydroxynicotinic acid amide 0.10
Malic acid 0.10
Hyaluronic acid Na 0.01
(Acryloyldimethyltaurate ammonium / VP) copolymer 0.05
Stearoxyhydroxypropylmethylcellulose 0.20
Zinc phenol sulfonate 0.20
PEG-60 hydrogenated castor oil 0.20
Glycyrrhizic acid 2K 0.05
Diethylenetriaminepentaacetic acid 0.06
Vitamin B6 hydrochloride 0.10
Fumaric acid 0.05
Sodium fumarate Appropriate amount of purified water Total amount of 100 parts B ethanol 30.00
Tocopherol 0.01
Menthol 0.01
Chlorophenol 0.02
Methylparaben 0.15
--------------------------------------
(Preparation method)
Both part A and part B were dissolved at room temperature, and part B was gradually added to part A while stirring to make it uniform.

Example 25 Carmine lotion A whitening carmine lotion having the following formulation was prepared. This carmine lotion was a carmine lotion having an appropriate viscosity, excellent spreading, and a smooth feeling.

Component Blending amount (% by weight)
--------------------------------------
Part A Calamine 0.40
Kaolin 4.00
Mg carbonate 0.10
Purified water 20.00
B part hydroxynicotinic acid amide 0.50
(Acryloyldimethyltaurate ammonium / VP) copolymer 0.30
(Acryloyldimethyltaurine / methacrylic acid
Behenez-25) copolymer 0.05
1,3-butylene glycol 2.00
Hydroxyethyl ethylenediamine triacetic acid 0.15
Allantoin 0.10
Citric acid 0.05
Sodium citrate appropriate amount Hinokitiol 0.02
Purified water Total amount of 100 parts ethanol 20.00
Canful 0.05
Methylparaben 0.20
--------------------------------------
(Preparation method)
Part A is dispersed. Both part B and part C were dissolved at room temperature, and part C was gradually added to part B with stirring, and further, part A was gradually added while stirring to make it uniform.

Example 26 Deodorant Lotion A whitening deodorant lotion having the following formulation was prepared. This deodorant lotion was a deodorant lotion having an appropriate viscosity, excellent in spreading and refreshing feeling.

Component Blending amount (% by weight)
--------------------------------------
Part A purified water A total amount of 100 (styrene / DVB) copolymer 0.20
Tea dry distillation solution 0.50
Benzalkonium chloride 0.05
Na chloride 0.10
Carboxymethyl chitin 0.02
(Acryloyldimethyltaurine / methacrylic acid
Behenez-25) copolymer 0.10
Hydroxyethane diphosphonic acid solution (60%) 0.05
Succinic acid 0.05
Sodium succinate appropriate amount hydroxynicotinic acid 1.00
Part B denatured alcohol 50.00
Methylparaben 0.20
--------------------------------------
(Preparation method)
Both part A and part B were dissolved at room temperature, and part B was gradually added to part A while stirring to make it uniform.

Example 27 Deodorant (Antiperspirant)
A whitening deodorant (antiperspirant) having the following formulation was prepared. This whitening deodorant has the effect of making the skin lighter.

Component Blending amount (% by weight)
--------------------------------------
Part A hydroxynicotinic acid amide 0.80
Purified water Total amount of 100 (acryloyldimethyltaurate ammonium / VP) copolymer 0.30
Stearoxyhydroxypropylmethylcellulose 0.20
(Acryloyldimethyltaurine / methacrylic acid
Behenez-25) copolymer 0.30
Methylparaben 0.10
Na chloride 0.01
Citric acid 0.05
Sodium citrate appropriate amount hydroxyethane diphosphonic acid solution (60%) 0.10
Laureth-21 0.10
Benzalkonium chloride 0.05
Chlorhydroxyaluminum 0.20
Part B denatured alcohol 40.00
Propylparaben 0.10
Isopropyl methylphenol 0.50
--------------------------------------
(Preparation method)
Both part A and part B were dissolved at room temperature, and part B was gradually added to part A while stirring to make it uniform.

Example 28 Moisture Pack A whitening moisture pack having the following formulation was prepared. This whitening moist chair pack enhances the moisturizing effect, softens the skin, gives a moist feeling, and provides an excellent cleaning action. In addition, it was a moisture pack with an appropriate viscosity, excellent spread and moisturizing feeling.

Component Blending amount (% by weight)
--------------------------------------
Part A polyvinyl alcohol 13.00
Acryloyldimethyltaurine ammonium / VP) copolymer 0.80
Stearoxyhydroxypropylmethylcellulose 2.00
Sodium alginate 0.50
1,3-butylene glycol 3.00
Alginic acid K 0.50
(Styrene / Vinylpyrrolidone) Copolymer 1.50
Part B Landool-G (Nippon Seika) 0.30
Hydroxynicotinamide 2.00
PCA Glyceres-25 isostearate-25 1.50
Denatured alcohol 8.00
PEG / PPG-5 / 30 copolymer 1.00
Ores-10 phosphate DEA 1.00
Glycyrrhizic acid 2K 0.05
Tocopherol 0.10
Methylparaben 0.20
Hyaluronic acid Na 0.05
Na chloride 0.30
Hydroxyethyl ethylenediamine triacetic acid 0.20
Ethylhexyl glycerin 0.02
Fumaric acid 0.05
Sodium fumarate Appropriate amount Purified water Total amount of 100 ----------------------------- −
(Preparation method)
Part A is heated and swollen at 50 ° C. Gradually add part B to part A with stirring and mix uniformly. The mixture was cooled with stirring, and stirring was stopped at 30 to 25 ° C.

Example 29 Whitening lotion A whitening lotion having the following formulation was prepared. This whitening lotion had a moderate viscosity, was excellent in spreading, and had a penetrating feeling.

Component Blending amount (% by weight)
--------------------------------------
Part A hydroxynicotinic acid 1.00
(Acryloyldimethyltaurine / methacrylic acid
Behenez-25) copolymer 0.02
Stearoxyhydroxypropylmethylcellulose 0.05
Succinoglucan 0.03
Purified water 20.00
Part B DPG 2.00
BG 2.00
Citric acid 0.10
Sodium citrate appropriate amount ethanol 8.00
Phenoxyethanol 0.20
Photosensitive Element 301 0.01
Methylparaben 0.10
EDTA-2Na 0.10
Purified water Total amount of 100 --------------------------------------
(Preparation method)
Part A was mixed and stirred to give a viscous liquid. Part B was mixed and dissolved uniformly. Part A was added to part B and stirred to dissolve uniformly.

Example 30 Whitening serum A whitening serum having the following formulation was prepared. This whitening serum had a smooth feel while softening the skin and keeping the skin fresh and smooth.

Component Blending amount (% by weight)
--------------------------------------
Part A (acryloyldimethyltaurate ammonium / VP) copolymer 0.30
Sodium hyaluronate 0.40
(Acryloyldimethyltaurine /
Methenic acid behenes-25) copolymer 0.30
Purified water 20.00
Part B hydroxynicotinic acid 0.50
Purified water 15.00
Part C glycyrrhizic acid 2K 0.10
DPG 2.00
BG 5.00
Succinic acid 0.05
Sodium succinate appropriate amount Tremoist-TP (Nippon Seika) 0.20
Ethanol 5.00
Phenoxyethanol 0.20
Methylparaben 0.10
Hydroxyethane diphosphonic acid solution (60%) 0.07
Purified water Total amount of 100 --------------------------------------
(Preparation method)
Part A was mixed and stirred to give a viscous liquid. Part B was mixed and dissolved uniformly. Part C was mixed and heated to about 70 ° C. and dissolved uniformly. Cooled and added parts A and B to part C at about 50 ° C. and stirred to dissolve uniformly.

Example 31 Whitening Skin Care Cream A whitening skin care cream having the following formulation was prepared. This whitening skin care cream was a cream excellent in the effect of imparting a moist feeling.

Component Blending amount (% by weight)
--------------------------------------
Part A Arbutin 3.00
Glycerin 3.00
Squalane 3.00
Jojoba oil 3.00
Palm kernel oil 3.10
Glyceryl stearate 2.30
PEG-60 glyceryl isostearate 1.40
Stearic acid PG (SE) 1.30
Stearyl alcohol 3.00
Behenyl alcohol 2.00
Dimethicone 1.50
Ethylparaben 0.10
Part B stearoxyhydroxypropyl methylcellulose 0.20
Pullulan 0.50
(Acryloyldimethyltaurine / methacrylic acid
Behenez-25) copolymer 0.30
Purified water 20.00
Part C Hydroxynicotinamide 2.00
Purified water 8.00
D part methyl paraben 0.15
Hydroxyethane diphosphonic acid solution (60%) 0.08
Citric acid 0.01
Na citrate Suitable amount Purified water Total amount to be 100-------------------------------- −
(Preparation method)
Part A was mixed and heated to about 70 ° C. to dissolve evenly. Part B was mixed and stirred to give a viscous liquid. Part C was mixed and dissolved uniformly. Part D was mixed and heated to about 70 ° C. and dissolved uniformly. After adding D part to A part and emulsifying with a homomixer, it cooled and added C part and B part at about 50 degreeC, and it stirred and melt | dissolved uniformly.

Example 32 Whitening emulsion A whitening emulsion having the following formulation was prepared. This whitening emulsion was excellent in the effect of imparting a moist feeling.

Component Blending amount (% by weight)
--------------------------------------
Part A Squalane 8.00
IOTG (Nihon Seika) 8.00
Cetyl dimethicone copolyol 1.00
Polyglyceryl diisostearate-3 0.80
Polysorbate 40 1.00
Glyceryl stearate 1.00
Tetraoleic acid Solves-60 1.00
Dimethicone (10cs) 4.00
Ethylparaben 0.10
Methylchloroisothiazolinone 0.01
Part B (acryloyldimethyltaurate ammonium / VP) copolymer 0.10
Stearoxyhydroxypropylmethylcellulose 0.20
Tremoist-TP (Nippon Seika) 0.50
Purified water 20.00
Part C Hydroxynicotinamide 1.50
Purified water 5.00
Part D methyl paraben 0.10
Phenoxyethanol 0.20
Hydrolyzed collagen 0.20
Hydrolyzed keratin 0.20
Diethylenetriaminepentaacetic acid 0.08
Citric acid 0.05
Sodium citrate appropriate amount carbomer 0.50
Hydroxide K 0.20
Purified water Total amount of 100 --------------------------------------
(Preparation method)
Part A was mixed and heated to about 70 ° C. to dissolve evenly. Part B was mixed and stirred to give a viscous liquid. Part C was mixed and dissolved uniformly. Part D was mixed and heated to about 70 ° C. and dissolved uniformly. After adding D part to A part and emulsifying with a homomixer, it cooled and added C part and B part at about 50 degreeC, and it stirred and melt | dissolved uniformly.

Claims (1)

A cosmetic for skin or an external preparation for skin used for whitening, which comprises a hydroxynicotinic acid amide derivative represented by the following general formula (2).

(In the formula, R1 and R2 each independently represent a hydrogen atom or a linear or branched hydrocarbon group having 1 to 22 carbon atoms which may be substituted with a hydroxyl group)