CN117281746B - Freckle-removing anti-aging skin care composition and preparation method thereof - Google Patents
Freckle-removing anti-aging skin care composition and preparation method thereof Download PDFInfo
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- CN117281746B CN117281746B CN202311340950.4A CN202311340950A CN117281746B CN 117281746 B CN117281746 B CN 117281746B CN 202311340950 A CN202311340950 A CN 202311340950A CN 117281746 B CN117281746 B CN 117281746B
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Abstract
The invention discloses a skin care composition for removing spots and resisting aging and a preparation method thereof, wherein the main components comprise butter fruit oil, gentian extract, sage extract, lysimachia christinae hance extract, flaxseed extract and acetyl tetrapeptide-11, the active components contained in the composition can quickly penetrate into skin epidermis, stimulate metabolism of skin cells, promote synthesis of collagen and elastin, and particularly the butter fruit oil and flaxseed extract have obvious antioxidation effect, can neutralize free radicals, reduce damage of skin cells and prevent skin aging. The skin care composition is rich in natural plant essence, has reasonable formula and no toxic or side effect, and can obviously lighten color spots and fine lines caused by ultraviolet irradiation after being used, and the skin is white, ruddy, compact and elastic.
Description
Technical Field
The invention relates to the technical field of skin care cosmetic processing, in particular to a freckle-removing and anti-aging skin care composition and a preparation method thereof.
Background
Human skin is an organ that is prone to exhibit aging. With age, the aging characteristics of the skin also follow: increased wrinkles, loose, yellowish skin, reduced gloss, smoothness, coarser texture, increased stain, etc. It is currently widely accepted that the intrinsic cause of skin stain aging is mainly both endogenous and exogenous. Endogenous factors include genetic factors, hormonal shortages, and the like. Exogenous factors include: pollution factors, namely exhaust gases growing in the atmosphere and pollution caused by various pollutants form a large amount of free radicals, and the attack of the free radicals leads to death and rapid aging of skin cells, such as choking skin, pore blocking, fragile skin and the like; photoaging, i.e., some of the very detrimental effects on the skin due to the accumulation of UVA/UVB radiation, such as dermal tissue disorders, thin the epidermal dermal connective tissue that governs the fine-tuning of the skin. In addition, excessive ultraviolet exposure is also a major cause of increased premature aging and color spots on facial skin.
The skin care products on the market at present often cannot achieve the aim of fundamentally protecting skin due to the problems of chemical agents, strong acid and alkali, chemical preservatives and the like, and can also lead the skin to be dependent or have strong irritation to the skin. Thus, the advent of a healthy, non-irritating skin care composition has become an urgent need. The invention takes the butter fruit tree fruit fat, the gentian root extract, the sage extract, the lysimachia christinae hance extract and the flaxseed extract as main components for removing spots and resisting aging, and achieves the purpose of removing spots and resisting aging of skin through the combination of the fruit fat substances and the active components of traditional Chinese medicines.
Disclosure of Invention
Aiming at the defects in the prior art, the invention provides a freckle-removing anti-aging skin care composition and a preparation method thereof, so as to solve the problems in the prior art.
In order to achieve the above purpose, the present invention provides the following technical solutions:
A skin care composition for removing freckle and resisting aging comprises the following raw materials in parts by weight: 5 to 10 parts of nicotinamide, 2 to 8 parts of polydimethylsiloxane, 2 to 8 parts of polysorbate-60, 25 to 65 parts of traditional Chinese medicine extract, 3 to 10 parts of butter fruit, 1 to 3 parts of hydroxypropyl cyclodextrin, 1 to 3 parts of tetrahydropyrimidine carboxylic acid, 1 to 5 parts of sodium hydroxide, 2 to 10 parts of cyclopeptide-161, 1 to 5 parts of acetyl tetrapeptide-11, 3 to 10 parts of hydroxypropyl tetrahydropyran triol, 3 to 7 parts of retinol, 1 to 5 parts of ascorbic acid, 2 to 9 parts of 3-o-ethyl ascorbic acid, 3 to 10 parts of sodium hyaluronate, 4 to 10 parts of astaxanthin, 5 to 10 parts of essence and 80 to 100 parts of water; the Chinese medicinal extract comprises one or more of radix Gentianae extract, herba Salvia officinalis extract, herba Lysimachiae Christinae extract, and semen Lini extract.
Preferably, the freckle-removing and anti-aging skin care composition comprises the following raw materials in parts by weight: 8 parts of nicotinamide, 5 parts of polydimethylsiloxane, 5 parts of polysorbate-60, 48 parts of a traditional Chinese medicine extract, 8 parts of shea butter, 2 parts of hydroxypropyl cyclodextrin, 2 parts of tetrahydropyrimidine carboxylic acid, 2 parts of sodium hydroxide, 8 parts of cyclopeptide-161, 3 parts of acetyl tetrapeptide-11, 7 parts of hydroxypropyl tetrahydropyran triol, 5 parts of retinol, 4 parts of ascorbic acid, 6 parts of 3-o-ethyl ascorbic acid, 7 parts of sodium hyaluronate, 6 parts of astaxanthin, 6 parts of essence and 90 parts of water.
Preferably, the traditional Chinese medicine extract comprises the following raw materials in parts by weight: 10-20 parts of gentian extract, 5-15 parts of sage extract, 5-20 parts of lysimachia christinae hance extract and 5-10 parts of flaxseed extract.
Preferably, the traditional Chinese medicine extract comprises the following raw materials in parts by weight: 15 parts of gentian extract, 10 parts of sage extract, 15 parts of desmodium extract and 8 parts of flaxseed extract.
Preferably, the preparation method of the butter tree fruit fat comprises the following steps:
s1, cutting the avocado pulp into pieces, and grinding the pieces into powder by using liquid nitrogen;
s2, adding the avocado powder into an ethanol water solution with the concentration of 60-75 v/v% and the total volume of 3-7 times, and carrying out ultrasonic vibration extraction for 20-40 min;
s3, carrying out reflux extraction in a water bath at the extraction temperature of 40-60 ℃ for 20-30 min, carrying out suction filtration, centrifuging, filtering, evaporating and recovering ethanol to obtain crude extract of the fruit fat;
s4, preparing the crude extract of the fruit fat into a solution with the concentration of 6-8 mg/ml, enabling the solution to flow through NKA-II macroporous adsorption resin at the flow rate of 2-4 BV/h for adsorption for 50-60 min, collecting effluent liquid, and concentrating to obtain the fruit fat of the Butyrospermum parkii.
Preferably, the preparation method of the sage extract comprises the following steps:
S1, crushing stems and leaves of sage, adding an extracting solution with the total volume of 5-9 times, leaching for 60-80 min, and filtering by a microfiltration membrane to obtain a primary extract, wherein the extracting solution is prepared from water, galactosyl glyceride and mannitol according to the mass ratio of 10 (2-5) (3-7)
Composition;
S2, mixing and stirring the primary extract and isopropyl myristate for 10-20 min, and regulating the pH value to be neutral to obtain the sage extract.
Preferably, the preparation method of the flaxseed extract comprises the following steps:
s1, cleaning fresh flaxseeds, putting the cleaned fresh flaxseeds into water, and filing the flaxseeds in the water, wherein the mass ratio of the flaxseeds to the water is 1 (5-15), and putting a water container into an ice water bath in the whole process to obtain a flaxseeds grinding liquid;
S2, adding 0.5-3 mol/L NaOH solution into the linseed grinding fluid to adjust the pH value to 8-11, and then adding alkaline protease accounting for 0.8-2% of the total mass and lipase accounting for 1-3% of the total mass for enzymolysis for 3-6 h;
S3, after the step S2 is finished, inactivating enzyme of the enzymolysis liquid in a water bath at the temperature of 90-98 ℃ for 20-30 min;
S4, placing the enzymatic hydrolysate after enzymatic hydrolysis at a preset temperature of 0-4 ℃ for refrigerated centrifugation, keeping the rotating speed at 8000-10000 r/min, collecting supernatant, filtering the supernatant by a filter element with the diameter of 0.3-0.6 mu m, and drying to obtain the flaxseed extract.
Preferably, the preparation method of the freckle-removing and anti-aging skin care composition comprises the following steps:
S1, adding nicotinamide, polydimethylsiloxane, polysorbate-60, tetrahydropyrimidine carboxylic acid, acetyl tetrapeptide-11, hydroxypropyl tetrahydropyran triol, retinol, ascorbic acid, 3-o-ethyl ascorbic acid and hydroxypropyl cyclodextrin into an emulsifying pot according to parts by weight, heating and continuously stirring to 70-80 ℃ until uniform and stable emulsion is formed, namely a component A;
s2, putting the traditional Chinese medicine extract, the fruit fat of the Butyrospermum parkii, the cyclic peptide-161, the essence and the water into a water phase pot according to parts by weight, heating and continuously stirring to 70-80 ℃ until the traditional Chinese medicine extract, the fruit fat of the Butyrospermum parkii, the cyclic peptide-161, the essence and the water are uniformly mixed, thus obtaining a component B;
And S3, stirring the component A at a stirring rate of 2000-3000 r/min, adding the component B while stirring, simultaneously adding sodium hyaluronate and astaxanthin, regulating the pH to 5-7 by using sodium hydroxide, naturally cooling to room temperature, and stopping stirring to obtain the skin care composition.
Preferably, the product dosage form of the composition is one or more of a liquid, an emulsion, a cream, an oil.
Preferably, the composition is one or more of a lotion, a skin cream, a cream concentrate, a emollient oil, a body wash.
Compared with the prior art, the invention has the beneficial effects that:
(1) The main components of the anti-freckle and anti-aging composition are butter fruit, gentian extract, sage extract, lysimachia christinae hance extract, flaxseed extract and acetyl tetrapeptide-11, and the composition contains active components such as alkaloids, glycosides, flavonoids and the like, can quickly penetrate into the epidermis of the skin, stimulate metabolism of skin cells, promote synthesis of collagen and elastin, and particularly has obvious antioxidation effect, can neutralize free radicals, reduce injury of the skin cells and prevent skin aging.
(2) The flaxseed extract is obtained by adopting a cold grinding and enzymolysis technology, flaxseed cells are broken by rasping wall breaking to release active micromolecular substances, solid and liquid phases are separated by centrifugation, the enzymolysis releases flaxseed protein isolate and lignan, and a membrane filtration system is used for molecular screening, so that the obtained micromolecular substances are easy to be absorbed by skin. In the skin care composition test prepared in example 3, DPPH free radical scavenging ability was 75.2%, OH free radical scavenging ability was 63.2%, tyrosinase activity was 43.2%, and HaCaT cell survival rate was 90.1%.
Detailed Description
The technical scheme of the invention is further described in detail below with reference to the specific embodiments.
Example 1
A skin care composition for removing freckle and resisting aging comprises the following raw materials in parts by weight: 5 parts of nicotinamide, 2 parts of polydimethylsiloxane, 2 parts of polysorbate-60, 25 parts of traditional Chinese medicine extract, 3 parts of shea butter, 1 part of hydroxypropyl cyclodextrin, 1-3 parts of tetrahydropyrimidine carboxylic acid, 1 part of sodium hydroxide, 2 parts of cyclopeptide-161, 1 part of acetyl tetrapeptide-11, 3 parts of hydroxypropyl tetrahydropyran triol, 3 parts of retinol, 1 part of ascorbic acid, 2 parts of 3-o-ethyl ascorbic acid, 3 parts of sodium hyaluronate, 4-10 parts of astaxanthin, 5 parts of essence and 80 parts of water;
The traditional Chinese medicine extract comprises the following raw materials in parts by weight: 10 parts of gentian extract, 5 parts of sage extract, 5 parts of desmodium extract and 5 parts of flaxseed extract.
The preparation method of the butter fruit tree fruit fat comprises the following steps:
s1, cutting the avocado pulp into pieces, and grinding the pieces into powder by using liquid nitrogen;
s2, adding the avocado powder into an ethanol water solution with the concentration of 60v/v% which is 3 times of the total volume, and carrying out ultrasonic vibration extraction for 20min;
S3, carrying out reflux extraction in a water bath, extracting for 20min at 40 ℃, carrying out suction filtration, centrifuging, filtering, evaporating and recovering ethanol to obtain crude extract of fruit fat;
S4, preparing the crude extract of the fruit fat into a solution of 6mg/ml, allowing the solution to flow through NKA-II macroporous adsorption resin at a flow rate of 2BV/h for adsorption for 50min, collecting effluent, concentrating, and freeze-drying to obtain the fruit fat of the Butyrospermum parkii.
The preparation method of the sage extract comprises the following steps:
S1, crushing stems and leaves of sage, adding an extracting solution with the total volume being 5 times of that of the stems and leaves of the sage, leaching for 60min, and filtering with a microfiltration membrane to obtain a primary extract, wherein the extracting solution consists of water, galactosyl glyceride and mannitol according to the mass ratio of 10:2:3;
s2, mixing and stirring the primary extract and isopropyl myristate for 10min, and regulating the pH value to be neutral to obtain the sage extract.
The preparation method of the flaxseed extract comprises the following steps:
S1, cleaning fresh flaxseeds, putting the cleaned fresh flaxseeds into water, and rasping the flaxseeds in the water, wherein the mass ratio of the flaxseeds to the water is 1:5, and putting a water container into an ice water bath in the whole process to obtain a flaxseeds grinding fluid;
s2, adding 0.5mol/L NaOH solution into the linseed grinding fluid to adjust the pH to 8, and then adding alkaline protease with the total mass of 0.8% and lipase with the total mass of 1% to carry out enzymolysis for 3 hours;
S3, after the step S2 is finished, inactivating enzyme of the enzymolysis liquid in a water bath at 90 ℃ for 20min;
S4, placing the enzymatic hydrolysate after enzymatic hydrolysis at a preset temperature of 0 ℃ for refrigerated centrifugation, keeping the rotating speed at 8000r/min, collecting supernatant, filtering the supernatant by a 0.3 mu m filter core, and drying to obtain the flaxseed extract.
The preparation method of the freckle-removing and anti-aging skin care composition is characterized by comprising the following steps of:
S1, adding nicotinamide, polydimethylsiloxane, polysorbate-60, tetrahydropyrimidine carboxylic acid, acetyl tetrapeptide-11, hydroxypropyl tetrahydropyran triol, retinol, ascorbic acid, 3-o-ethyl ascorbic acid and hydroxypropyl cyclodextrin into an emulsifying pot according to parts by weight, heating and continuously stirring to 70 ℃ until uniform and stable emulsion is formed, namely a component A;
s2, putting the traditional Chinese medicine extract, the fruit fat of the Butyrospermum parkii, the cyclic peptide-161, the essence and the water into a water phase pot according to parts by weight, heating and continuously stirring to 70 ℃ until the traditional Chinese medicine extract, the fruit fat of the Butyrospermum parkii, the cyclic peptide-161, the essence and the water are uniformly mixed, and obtaining a component B;
And S3, stirring the component A at a stirring rate of 2000r/min, adding the component B while stirring, simultaneously adding sodium hyaluronate and astaxanthin, regulating the pH to 5 by using sodium hydroxide, naturally cooling to room temperature, and stopping stirring to obtain the skin care composition.
Example 2
The freckle-removing and anti-aging skin care composition is characterized by comprising the following raw materials in parts by weight: 10 parts of nicotinamide, 8 parts of polydimethylsiloxane, 8 parts of polysorbate-60, 65 parts of traditional Chinese medicine extract, 10 parts of shea butter, 3 parts of hydroxypropyl cyclodextrin, 3 parts of tetrahydropyrimidine carboxylic acid, 5 parts of sodium hydroxide, 10 parts of cyclopeptide-161, 5 parts of acetyl tetrapeptide-11, 10 parts of hydroxypropyl tetrahydropyran triol, 7 parts of retinol, 5 parts of ascorbic acid, 9 parts of 3-o-ethyl ascorbic acid, 3-10 parts of sodium hyaluronate, 10 parts of astaxanthin, 10 parts of essence and 100 parts of water;
the traditional Chinese medicine extract comprises the following raw materials in parts by weight: 20 parts of gentian extract, 15 parts of sage extract, 20 parts of lysimachia christinae extract and 10 parts of flaxseed extract.
The preparation method of the butter fruit tree fruit fat comprises the following steps:
s1, cutting the avocado pulp into pieces, and grinding the pieces into powder by using liquid nitrogen;
S2, adding the avocado powder into an ethanol water solution with the concentration of 75v/v% and the total volume of 7 times, and carrying out ultrasonic vibration extraction for 40min;
s3, carrying out reflux extraction in a water bath, extracting for 30min at 60 ℃, carrying out suction filtration, centrifuging, filtering, evaporating and recovering ethanol to obtain crude extract of fruit fat;
S4, preparing the crude extract of the fruit fat into a solution of 8mg/ml, allowing the solution to flow through NKA-II macroporous adsorption resin at a flow rate of 4BV/h for adsorption for 60min, collecting effluent, concentrating, and freeze-drying to obtain the fruit fat of the Butyrospermum parkii.
The preparation method of the sage extract comprises the following steps:
S1, crushing stems and leaves of sage, adding an extracting solution with the total volume being 9 times of that of the stems and leaves of the sage, leaching for 80min, and filtering with a microfiltration membrane to obtain a primary extract, wherein the extracting solution consists of water, galactosyl glyceride and mannitol according to the mass ratio of 10:5:7;
S2, mixing and stirring the primary extract and isopropyl myristate for 20min, and regulating the pH value to be neutral to obtain the sage extract.
The preparation method of the flaxseed extract comprises the following steps:
S1, cleaning fresh flaxseeds, putting the cleaned fresh flaxseeds into water, and rasping the flaxseeds in the water, wherein the mass ratio of the flaxseeds to the water is 1:15, and putting a water container into an ice water bath in the whole process to obtain a flaxseeds grinding fluid;
S2, adding 0.5mol/L NaOH solution into the linseed grinding fluid to adjust the pH to 11, and then adding alkaline protease accounting for 2% of the total mass and lipase accounting for 3% of the total mass for enzymolysis for 3 hours;
S3, after the step S2 is finished, inactivating enzyme of the enzymolysis liquid in a water bath at 98 ℃ for 30min;
S4, placing the enzymatic hydrolysate after enzymatic hydrolysis at a preset temperature of 4 ℃ for refrigerated centrifugation, keeping the rotating speed at 10000r/min, collecting supernatant, filtering the supernatant by a 0.6 mu m filter core, and drying to obtain the flaxseed extract.
The preparation method of the freckle-removing and anti-aging skin care composition is characterized by comprising the following steps of:
S1, adding nicotinamide, polydimethylsiloxane, polysorbate-60, tetrahydropyrimidine carboxylic acid, acetyl tetrapeptide-11, hydroxypropyl tetrahydropyran triol, retinol, ascorbic acid, 3-o-ethyl ascorbic acid and hydroxypropyl cyclodextrin into an emulsifying pot according to parts by weight, heating and continuously stirring to 80 ℃ until uniform and stable emulsion is formed, namely a component A;
S2, putting the traditional Chinese medicine extract, the fruit fat of the Butyrospermum parkii, the cyclic peptide-161, the essence and the water into a water phase pot according to parts by weight, heating and continuously stirring to 80 ℃ until the traditional Chinese medicine extract, the fruit fat of the Butyrospermum parkii, the cyclic peptide-161, the essence and the water are uniformly mixed, and obtaining a component B;
And S3, stirring the component A at a stirring rate of 3000r/min, adding the component B while stirring, simultaneously adding sodium hyaluronate and astaxanthin, regulating the pH to 7 by using sodium hydroxide, naturally cooling to room temperature, and stopping stirring to obtain the skin care composition.
Example 3
A skin care composition for removing freckle and resisting aging comprises the following raw materials in parts by weight: 8 parts of nicotinamide, 5 parts of polydimethylsiloxane, 5 parts of polysorbate-60, 48 parts of a traditional Chinese medicine extract, 8 parts of shea butter, 2 parts of hydroxypropyl cyclodextrin, 2 parts of tetrahydropyrimidine carboxylic acid, 2 parts of sodium hydroxide, 8 parts of cyclopeptide-161, 3 parts of acetyl tetrapeptide-11, 7 parts of hydroxypropyl tetrahydropyran triol, 5 parts of retinol, 4 parts of ascorbic acid, 6 parts of 3-o-ethyl ascorbic acid, 7 parts of sodium hyaluronate, 6 parts of astaxanthin, 6 parts of essence and 90 parts of water;
the traditional Chinese medicine extract comprises the following raw materials in parts by weight: 15 parts of gentian extract, 10 parts of sage extract, 15 parts of desmodium extract and 8 parts of flaxseed extract.
The preparation method of the butter fruit tree fruit fat comprises the following steps:
s1, cutting the avocado pulp into pieces, and grinding the pieces into powder by using liquid nitrogen;
s2, adding the avocado powder into an ethanol water solution with the concentration of 70v/v% which is 5 times of the total volume, and carrying out ultrasonic vibration extraction for 30min;
S3, carrying out reflux extraction in a water bath, extracting for 25min at 50 ℃, carrying out suction filtration, centrifuging, filtering, evaporating and recovering ethanol to obtain crude extract of fruit fat;
S4, preparing the crude extract of the fruit fat into a solution of 7mg/ml, allowing the solution to flow through NKA-II macroporous adsorption resin at a flow rate of 3BV/h for adsorption for 55min, collecting effluent, concentrating, and freeze-drying to obtain the fruit fat of the Butyrospermum parkii.
The preparation method of the sage extract comprises the following steps:
S1, crushing stems and leaves of sage, adding an extracting solution with the total volume being 7 times of that of the stems and leaves of the sage, leaching for 70min, and filtering with a microfiltration membrane to obtain a primary extract, wherein the extracting solution consists of water, galactosyl glyceride and mannitol according to the mass ratio of 10:4:5;
s2, mixing and stirring the primary extract and isopropyl myristate for 15min, and regulating the pH value to be neutral to obtain the sage extract.
The preparation method of the flaxseed extract comprises the following steps:
S1, cleaning fresh flaxseeds, putting the cleaned fresh flaxseeds into water, and rasping the flaxseeds in the water, wherein the mass ratio of the flaxseeds to the water is 1:10, and putting a water container into an ice water bath in the whole process to obtain a flaxseeds grinding fluid;
S2, adding 2mol/L NaOH solution into the linseed grinding fluid to adjust the pH value to 9, and then adding 1% of alkaline protease and 2% of lipase by mass for enzymolysis for 5 hours;
S3, after the step S2 is finished, inactivating enzyme of the enzymolysis liquid in a water bath at 95 ℃ for 25min;
S4, placing the enzymatic hydrolysate after enzymatic hydrolysis at a preset temperature of 2 ℃ for refrigerated centrifugation, keeping the rotating speed at 9000r/min, collecting supernatant, filtering the supernatant through a 0.4 mu m filter element, and drying to obtain the flaxseed extract.
The preparation method of the freckle-removing and anti-aging skin care composition is characterized by comprising the following steps of:
S1, adding nicotinamide, polydimethylsiloxane, polysorbate-60, tetrahydropyrimidine carboxylic acid, acetyl tetrapeptide-11, hydroxypropyl tetrahydropyran triol, retinol, ascorbic acid, 3-o-ethyl ascorbic acid and hydroxypropyl cyclodextrin into an emulsifying pot according to parts by weight, heating and continuously stirring to 75 ℃ until uniform and stable emulsion is formed, namely a component A;
S2, putting the traditional Chinese medicine extract, the fruit fat of the Butyrospermum parkii, the cyclic peptide-161, the essence and the water into a water phase pot according to parts by weight, heating and continuously stirring to 75 ℃ until the traditional Chinese medicine extract, the fruit fat of the Butyrospermum parkii, the cyclic peptide-161, the essence and the water are uniformly mixed, and obtaining a component B;
And S3, stirring the component A at a stirring rate of 2500r/min, adding the component B while stirring, simultaneously adding sodium hyaluronate and astaxanthin, regulating the pH to 6 by using sodium hydroxide, naturally cooling to room temperature, and stopping stirring to obtain the skin care composition.
Comparative example 1
This comparative example differs from example 3 in that: the Salvia officinalis extract and semen Lini extract are not added, and the rest steps and components are unchanged.
A skin care composition for removing freckle and resisting aging comprises the following raw materials in parts by weight: 8 parts of nicotinamide, 5 parts of polydimethylsiloxane, 5 parts of polysorbate-60, 48 parts of a traditional Chinese medicine extract, 8 parts of shea butter, 2 parts of hydroxypropyl cyclodextrin, 2 parts of tetrahydropyrimidine carboxylic acid, 2 parts of sodium hydroxide, 8 parts of cyclopeptide-161, 3 parts of acetyl tetrapeptide-11, 7 parts of hydroxypropyl tetrahydropyran triol, 5 parts of retinol, 4 parts of ascorbic acid, 6 parts of 3-o-ethyl ascorbic acid, 7 parts of sodium hyaluronate, 6 parts of astaxanthin, 6 parts of essence and 90 parts of water;
the traditional Chinese medicine extract comprises the following raw materials in parts by weight: 15 parts of gentian extract and 15 parts of desmodium extract.
The preparation method of the butter fruit tree fruit fat comprises the following steps:
s1, cutting the avocado pulp into pieces, and grinding the pieces into powder by using liquid nitrogen;
s2, adding the avocado powder into an ethanol water solution with the concentration of 70v/v% which is 5 times of the total volume, and carrying out ultrasonic vibration extraction for 30min;
S3, carrying out reflux extraction in a water bath, extracting for 25min at 50 ℃, carrying out suction filtration, centrifuging, filtering, evaporating and recovering ethanol to obtain crude extract of fruit fat;
S4, preparing the crude extract of the fruit fat into a solution of 7mg/ml, allowing the solution to flow through NKA-II macroporous adsorption resin at a flow rate of 3BV/h for adsorption for 55min, collecting effluent, concentrating, and freeze-drying to obtain the fruit fat of the Butyrospermum parkii.
The preparation method of the freckle-removing and anti-aging skin care composition is characterized by comprising the following steps of:
S1, adding nicotinamide, polydimethylsiloxane, polysorbate-60, tetrahydropyrimidine carboxylic acid, acetyl tetrapeptide-11, hydroxypropyl tetrahydropyran triol, retinol, ascorbic acid, 3-o-ethyl ascorbic acid and hydroxypropyl cyclodextrin into an emulsifying pot according to parts by weight, heating and continuously stirring to 75 ℃ until uniform and stable emulsion is formed, namely a component A;
S2, putting the traditional Chinese medicine extract, the fruit fat of the Butyrospermum parkii, the cyclic peptide-161, the essence and the water into a water phase pot according to parts by weight, heating and continuously stirring to 75 ℃ until the traditional Chinese medicine extract, the fruit fat of the Butyrospermum parkii, the cyclic peptide-161, the essence and the water are uniformly mixed, and obtaining a component B;
And S3, stirring the component A at a stirring rate of 2500r/min, adding the component B while stirring, simultaneously adding sodium hyaluronate and astaxanthin, regulating the pH to 6 by using sodium hydroxide, naturally cooling to room temperature, and stopping stirring to obtain the skin care composition.
Comparative example 2
This comparative example differs from example 3 in that: the sage extract is not added, and the rest steps and components are unchanged.
A skin care composition for removing freckle and resisting aging comprises the following raw materials in parts by weight: 8 parts of nicotinamide, 5 parts of polydimethylsiloxane, 5 parts of polysorbate-60, 48 parts of a traditional Chinese medicine extract, 8 parts of shea butter, 2 parts of hydroxypropyl cyclodextrin, 2 parts of tetrahydropyrimidine carboxylic acid, 2 parts of sodium hydroxide, 8 parts of cyclopeptide-161, 3 parts of acetyl tetrapeptide-11, 7 parts of hydroxypropyl tetrahydropyran triol, 5 parts of retinol, 4 parts of ascorbic acid, 6 parts of 3-o-ethyl ascorbic acid, 7 parts of sodium hyaluronate, 6 parts of astaxanthin, 6 parts of essence and 90 parts of water;
The traditional Chinese medicine extract comprises the following raw materials in parts by weight: 15 parts of gentian extract, 15 parts of desmodium extract and 8 parts of flaxseed extract.
The preparation method of the butter fruit tree fruit fat comprises the following steps:
s1, cutting the avocado pulp into pieces, and grinding the pieces into powder by using liquid nitrogen;
s2, adding the avocado powder into an ethanol water solution with the concentration of 70v/v% which is 5 times of the total volume, and carrying out ultrasonic vibration extraction for 30min;
S3, carrying out reflux extraction in a water bath, extracting for 25min at 50 ℃, carrying out suction filtration, centrifuging, filtering, evaporating and recovering ethanol to obtain crude extract of fruit fat;
S4, preparing the crude extract of the fruit fat into a solution of 7mg/ml, allowing the solution to flow through NKA-II macroporous adsorption resin at a flow rate of 3BV/h for adsorption for 55min, collecting effluent, concentrating, and freeze-drying to obtain the fruit fat of the Butyrospermum parkii.
The preparation method of the flaxseed extract comprises the following steps:
S1, cleaning fresh flaxseeds, putting the cleaned fresh flaxseeds into water, and rasping the flaxseeds in the water, wherein the mass ratio of the flaxseeds to the water is 1:10, and putting a water container into an ice water bath in the whole process to obtain a flaxseeds grinding fluid;
S2, adding 2mol/L NaOH solution into the linseed grinding fluid to adjust the pH value to 9, and then adding 1% of alkaline protease and 2% of lipase by mass for enzymolysis for 5 hours;
S3, after the step S2 is finished, inactivating enzyme of the enzymolysis liquid in a water bath at 95 ℃ for 25min;
S4, placing the enzymatic hydrolysate after enzymatic hydrolysis at a preset temperature of 2 ℃ for refrigerated centrifugation, keeping the rotating speed at 9000r/min, collecting supernatant, filtering the supernatant through a 0.4 mu m filter element, and drying to obtain the flaxseed extract.
The preparation method of the freckle-removing and anti-aging skin care composition is characterized by comprising the following steps of:
S1, adding nicotinamide, polydimethylsiloxane, polysorbate-60, tetrahydropyrimidine carboxylic acid, acetyl tetrapeptide-11, hydroxypropyl tetrahydropyran triol, retinol, ascorbic acid, 3-o-ethyl ascorbic acid and hydroxypropyl cyclodextrin into an emulsifying pot according to parts by weight, heating and continuously stirring to 75 ℃ until uniform and stable emulsion is formed, namely a component A;
S2, putting the traditional Chinese medicine extract, the fruit fat of the Butyrospermum parkii, the cyclic peptide-161, the essence and the water into a water phase pot according to parts by weight, heating and continuously stirring to 75 ℃ until the traditional Chinese medicine extract, the fruit fat of the Butyrospermum parkii, the cyclic peptide-161, the essence and the water are uniformly mixed, and obtaining a component B;
And S3, stirring the component A at a stirring rate of 2500r/min, adding the component B while stirring, simultaneously adding sodium hyaluronate and astaxanthin, regulating the pH to 6 by using sodium hydroxide, naturally cooling to room temperature, and stopping stirring to obtain the skin care composition.
Comparative example 3
This comparative example differs from example 3 in that: the flaxseed extract is not added, and the rest steps and components are unchanged.
A skin care composition for removing freckle and resisting aging comprises the following raw materials in parts by weight: 8 parts of nicotinamide, 5 parts of polydimethylsiloxane, 5 parts of polysorbate-60, 48 parts of a traditional Chinese medicine extract, 8 parts of shea butter, 2 parts of hydroxypropyl cyclodextrin, 2 parts of tetrahydropyrimidine carboxylic acid, 2 parts of sodium hydroxide, 8 parts of cyclopeptide-161, 3 parts of acetyl tetrapeptide-11, 7 parts of hydroxypropyl tetrahydropyran triol, 5 parts of retinol, 4 parts of ascorbic acid, 6 parts of 3-o-ethyl ascorbic acid, 7 parts of sodium hyaluronate, 6 parts of astaxanthin, 6 parts of essence and 90 parts of water;
The traditional Chinese medicine extract comprises the following raw materials in parts by weight: 15 parts of gentian extract, 10 parts of sage extract and 15 parts of desmodium extract.
The preparation method of the butter fruit tree fruit fat comprises the following steps:
s1, cutting the avocado pulp into pieces, and grinding the pieces into powder by using liquid nitrogen;
s2, adding the avocado powder into an ethanol water solution with the concentration of 70v/v% which is 5 times of the total volume, and carrying out ultrasonic vibration extraction for 30min;
S3, carrying out reflux extraction in a water bath, extracting for 25min at 50 ℃, carrying out suction filtration, centrifuging, filtering, evaporating and recovering ethanol to obtain crude extract of fruit fat;
S4, preparing the crude extract of the fruit fat into a solution of 7mg/ml, allowing the solution to flow through NKA-II macroporous adsorption resin at a flow rate of 3BV/h for adsorption for 55min, collecting effluent, concentrating, and freeze-drying to obtain the fruit fat of the Butyrospermum parkii.
The preparation method of the sage extract comprises the following steps:
S1, crushing stems and leaves of sage, adding an extracting solution with the total volume being 7 times of that of the stems and leaves of the sage, leaching for 70min, and filtering with a microfiltration membrane to obtain a primary extract, wherein the extracting solution consists of water, galactosyl glyceride and mannitol according to the mass ratio of 10:4:5;
s2, mixing and stirring the primary extract and isopropyl myristate for 15min, and regulating the pH value to be neutral to obtain the sage extract.
The preparation method of the freckle-removing and anti-aging skin care composition is characterized by comprising the following steps of:
S1, adding nicotinamide, polydimethylsiloxane, polysorbate-60, tetrahydropyrimidine carboxylic acid, acetyl tetrapeptide-11, hydroxypropyl tetrahydropyran triol, retinol, ascorbic acid, 3-o-ethyl ascorbic acid and hydroxypropyl cyclodextrin into an emulsifying pot according to parts by weight, heating and continuously stirring to 75 ℃ until uniform and stable emulsion is formed, namely a component A;
S2, putting the traditional Chinese medicine extract, the fruit fat of the Butyrospermum parkii, the cyclic peptide-161, the essence and the water into a water phase pot according to parts by weight, heating and continuously stirring to 75 ℃ until the traditional Chinese medicine extract, the fruit fat of the Butyrospermum parkii, the cyclic peptide-161, the essence and the water are uniformly mixed, and obtaining a component B;
And S3, stirring the component A at a stirring rate of 2500r/min, adding the component B while stirring, simultaneously adding sodium hyaluronate and astaxanthin, regulating the pH to 6 by using sodium hydroxide, naturally cooling to room temperature, and stopping stirring to obtain the skin care composition.
Comparative example 4
This comparative example differs from example 3 in that: the traditional Chinese medicine extract is not added, and the rest steps and components are unchanged.
A skin care composition for removing freckle and resisting aging comprises the following raw materials in parts by weight: 8 parts of nicotinamide, 5 parts of polydimethylsiloxane, 5 parts of polysorbate-60, 8 parts of shea butter, 2 parts of hydroxypropyl cyclodextrin, 2 parts of tetrahydropyrimidine carboxylic acid, 2 parts of sodium hydroxide, 8 parts of cyclopeptide-161, 3 parts of acetyl tetrapeptide-11, 7 parts of hydroxypropyl tetrahydropyran triol, 5 parts of retinol, 4 parts of ascorbic acid, 6 parts of 3-o-ethyl ascorbic acid, 7 parts of sodium hyaluronate, 6 parts of astaxanthin, 6 parts of essence and 90 parts of water;
the preparation method of the butter fruit tree fruit fat comprises the following steps:
s1, cutting the avocado pulp into pieces, and grinding the pieces into powder by using liquid nitrogen;
s2, adding the avocado powder into an ethanol water solution with the concentration of 70v/v% which is 5 times of the total volume, and carrying out ultrasonic vibration extraction for 30min;
S3, carrying out reflux extraction in a water bath, extracting for 25min at 50 ℃, carrying out suction filtration, centrifuging, filtering, evaporating and recovering ethanol to obtain crude extract of fruit fat;
S4, preparing the crude extract of the fruit fat into a solution of 7mg/ml, allowing the solution to flow through NKA-II macroporous adsorption resin at a flow rate of 3BV/h for adsorption for 55min, collecting effluent, concentrating, and freeze-drying to obtain the fruit fat of the Butyrospermum parkii.
The preparation method of the freckle-removing and anti-aging skin care composition is characterized by comprising the following steps of:
S1, adding nicotinamide, polydimethylsiloxane, polysorbate-60, tetrahydropyrimidine carboxylic acid, acetyl tetrapeptide-11, hydroxypropyl tetrahydropyran triol, retinol, ascorbic acid, 3-o-ethyl ascorbic acid and hydroxypropyl cyclodextrin into an emulsifying pot according to parts by weight, heating and continuously stirring to 75 ℃ until uniform and stable emulsion is formed, namely a component A;
S2, putting the butter, the cyclopeptide-161, the essence and the water into a water phase pot according to parts by weight, heating and continuously stirring to 75 ℃ until the components are uniformly mixed, and obtaining a component B;
And S3, stirring the component A at a stirring rate of 2500r/min, adding the component B while stirring, simultaneously adding sodium hyaluronate and astaxanthin, regulating the pH to 6 by using sodium hydroxide, naturally cooling to room temperature, and stopping stirring to obtain the skin care composition.
Comparative example 5
This comparative example differs from example 3 in that: the butter of the Butyrospermum parkii is not added, and the rest steps and components are unchanged.
A skin care composition for removing freckle and resisting aging comprises the following raw materials in parts by weight: 8 parts of nicotinamide, 5 parts of polydimethylsiloxane, 5 parts of polysorbate-60, 48 parts of a traditional Chinese medicine extract, 2 parts of hydroxypropyl cyclodextrin, 2 parts of tetrahydropyrimidine carboxylic acid, 2 parts of sodium hydroxide, 8 parts of cyclopeptide-161, 3 parts of acetyl tetrapeptide-11, 7 parts of hydroxypropyl tetrahydropyran triol, 5 parts of retinol, 4 parts of ascorbic acid, 6 parts of 3-o-ethyl ascorbic acid, 7 parts of sodium hyaluronate, 6 parts of astaxanthin, 6 parts of essence and 90 parts of water;
the traditional Chinese medicine extract comprises the following raw materials in parts by weight: 15 parts of gentian extract, 10 parts of sage extract, 15 parts of desmodium extract and 8 parts of flaxseed extract.
The preparation method of the sage extract comprises the following steps:
S1, crushing stems and leaves of sage, adding an extracting solution with the total volume being 7 times of that of the stems and leaves of the sage, leaching for 70min, and filtering with a microfiltration membrane to obtain a primary extract, wherein the extracting solution consists of water, galactosyl glyceride and mannitol according to the mass ratio of 10:4:5;
s2, mixing and stirring the primary extract and isopropyl myristate for 15min, and regulating the pH value to be neutral to obtain the sage extract.
The preparation method of the flaxseed extract comprises the following steps:
S1, cleaning fresh flaxseeds, putting the cleaned fresh flaxseeds into water, and rasping the flaxseeds in the water, wherein the mass ratio of the flaxseeds to the water is 1:10, and putting a water container into an ice water bath in the whole process to obtain a flaxseeds grinding fluid;
S2, adding 2mol/L NaOH solution into the linseed grinding fluid to adjust the pH value to 9, and then adding 1% of alkaline protease and 2% of lipase by mass for enzymolysis for 5 hours;
S3, after the step S2 is finished, inactivating enzyme of the enzymolysis liquid in a water bath at 95 ℃ for 25min;
S4, placing the enzymatic hydrolysate after enzymatic hydrolysis at a preset temperature of 2 ℃ for refrigerated centrifugation, keeping the rotating speed at 9000r/min, collecting supernatant, filtering the supernatant through a 0.4 mu m filter element, and drying to obtain the flaxseed extract.
The preparation method of the freckle-removing and anti-aging skin care composition is characterized by comprising the following steps of:
S1, adding nicotinamide, polydimethylsiloxane, polysorbate-60, tetrahydropyrimidine carboxylic acid, acetyl tetrapeptide-11, hydroxypropyl tetrahydropyran triol, retinol, ascorbic acid, 3-o-ethyl ascorbic acid and hydroxypropyl cyclodextrin into an emulsifying pot according to parts by weight, heating and continuously stirring to 75 ℃ until uniform and stable emulsion is formed, namely a component A;
s2, adding the traditional Chinese medicine extract, the cyclopeptide-161, the essence and the water into a water phase pot according to parts by weight, heating and continuously stirring to 75 ℃ until the traditional Chinese medicine extract, the cyclopeptide-161, the essence and the water are uniformly mixed, and obtaining a component B;
And S3, stirring the component A at a stirring rate of 2500r/min, adding the component B while stirring, simultaneously adding sodium hyaluronate and astaxanthin, regulating the pH to 6 by using sodium hydroxide, naturally cooling to room temperature, and stopping stirring to obtain the skin care composition.
Comparative example 6
This comparative example differs from example 3 in that: extracting semen Lini extract at room temperature, and keeping the rest components and steps unchanged.
A skin care composition for removing freckle and resisting aging comprises the following raw materials in parts by weight: 8 parts of nicotinamide, 5 parts of polydimethylsiloxane, 5 parts of polysorbate-60, 48 parts of a traditional Chinese medicine extract, 8 parts of shea butter, 2 parts of hydroxypropyl cyclodextrin, 2 parts of tetrahydropyrimidine carboxylic acid, 2 parts of sodium hydroxide, 8 parts of cyclopeptide-161, 3 parts of acetyl tetrapeptide-11, 7 parts of hydroxypropyl tetrahydropyran triol, 5 parts of retinol, 4 parts of ascorbic acid, 6 parts of 3-o-ethyl ascorbic acid, 7 parts of sodium hyaluronate, 6 parts of astaxanthin, 6 parts of essence and 90 parts of water;
the traditional Chinese medicine extract comprises the following raw materials in parts by weight: 15 parts of gentian extract, 10 parts of sage extract, 15 parts of desmodium extract and 8 parts of flaxseed extract.
The preparation method of the butter fruit tree fruit fat comprises the following steps:
s1, cutting the avocado pulp into pieces, and grinding the pieces into powder by using liquid nitrogen;
s2, adding the avocado powder into an ethanol water solution with the concentration of 70v/v% which is 5 times of the total volume, and carrying out ultrasonic vibration extraction for 30min;
S3, carrying out reflux extraction in a water bath, extracting for 25min at 50 ℃, carrying out suction filtration, centrifuging, filtering, evaporating and recovering ethanol to obtain crude extract of fruit fat;
S4, preparing the crude extract of the fruit fat into a solution of 7mg/ml, allowing the solution to flow through NKA-II macroporous adsorption resin at a flow rate of 3BV/h for adsorption for 55min, collecting effluent, concentrating, and freeze-drying to obtain the fruit fat of the Butyrospermum parkii.
The preparation method of the sage extract comprises the following steps:
S1, crushing stems and leaves of sage, adding an extracting solution with the total volume being 7 times of that of the stems and leaves of the sage, leaching for 70min, and filtering with a microfiltration membrane to obtain a primary extract, wherein the extracting solution consists of water, galactosyl glyceride and mannitol according to the mass ratio of 10:4:5;
s2, mixing and stirring the primary extract and isopropyl myristate for 15min, and regulating the pH value to be neutral to obtain the sage extract.
The preparation method of the flaxseed extract comprises the following steps:
s1, cleaning fresh flaxseeds, putting the cleaned fresh flaxseeds into water, and filing the flaxseeds in the water, wherein the mass ratio of the flaxseeds to the water is 1:10, so as to obtain a flaxseeds grinding fluid;
S2, adding 2mol/L NaOH solution into the linseed grinding fluid to adjust the pH value to 9, and then adding 1% of alkaline protease and 2% of lipase by mass for enzymolysis for 5 hours;
S3, after the step S2 is finished, inactivating enzyme of the enzymolysis liquid in a water bath at 95 ℃ for 25min;
S4, centrifuging the enzymolysis liquid after enzymolysis, keeping the rotating speed at 9000r/min, collecting supernatant, filtering the supernatant through a 0.4 mu m filter core, and drying to obtain the flaxseed extract.
The preparation method of the freckle-removing and anti-aging skin care composition is characterized by comprising the following steps of:
S1, adding nicotinamide, polydimethylsiloxane, polysorbate-60, tetrahydropyrimidine carboxylic acid, acetyl tetrapeptide-11, hydroxypropyl tetrahydropyran triol, retinol, ascorbic acid, 3-o-ethyl ascorbic acid and hydroxypropyl cyclodextrin into an emulsifying pot according to parts by weight, heating and continuously stirring to 75 ℃ until uniform and stable emulsion is formed, namely a component A;
S2, putting the traditional Chinese medicine extract, the fruit fat of the Butyrospermum parkii, the cyclic peptide-161, the essence and the water into a water phase pot according to parts by weight, heating and continuously stirring to 75 ℃ until the traditional Chinese medicine extract, the fruit fat of the Butyrospermum parkii, the cyclic peptide-161, the essence and the water are uniformly mixed, and obtaining a component B;
And S3, stirring the component A at a stirring rate of 2500r/min, adding the component B while stirring, simultaneously adding sodium hyaluronate and astaxanthin, regulating the pH to 6 by using sodium hydroxide, naturally cooling to room temperature, and stopping stirring to obtain the skin care composition.
Test example 1DPPH and-OH radical scavenging ability
1.1 Test methods
(1) Determination of the ability to scavenge 1, 2-diphenyl picrate hydrazyl radical (DPPH-): preparing 2mg/mL skin care composition solution and 0.2mmol/L DPPH solution with absolute ethyl alcohol, respectively taking 2mL skin care composition solution and DPPH solution in a test tube, shaking uniformly, standing at room temperature for 30min, and obtaining absorbance A 1; and simultaneously measuring absorbance A 2 of 2mL of DPPH solution mixed with 2mL of distilled water and absorbance A 3 of 2mL of skin care composition solution mixed with 2mL of absolute ethyl alcohol, and carrying out light-proof reaction. At 517nm, the absorbance was measured, and the clearance was calculated as:
(2) Determination of the ability to scavenge hydroxyl (-OH) radicals: the test adopts a salicylic acid method, 9mmol/L FeSO 4 2mL,9mmol/L salicylic acid 2mL, ethanol 2mL, skin care composition 2mL,8.8mmol/L H 2O2 mL are sequentially added into a colorimetric tube, wherein H 2O2 starts the whole reaction, after the reaction is carried out for 0.5H at 37 ℃, the absorbance A 1 of a sample is measured at 510nm, distilled water is used for replacing skin care composition solution to be blank zeroed to measure the absorbance A 0, and the formula is as follows:
1.2 test results
The results are shown in Table 1:
TABLE 1DPPH and-OH free radical scavenging ability
| Sequence number | DPPH radical scavenging ability (%) | -OH radical scavenging ability (%) |
| Example 1 | 73.2 | 60.1 |
| Example 2 | 68.1 | 61.5 |
| Example 3 | 75.2 | 63.2 |
| Comparative example 1 | 52.5 | 42.3 |
| Comparative example 2 | 58.2 | 48.1 |
| Comparative example 3 | 60.8 | 50.6 |
| Comparative example 4 | 58.6 | 54.2 |
| Comparative example 5 | 42.2 | 33.6 |
| Comparative example 6 | 63.1 | 55.9 |
As can be seen from Table 1, the anti-freckle and anti-aging skin care composition has the functions of removing DPPH free radical and-OH free radical, especially the best effect of example 3, the DPPH free radical removing capacity is 75.2 percent, the-OH free radical removing capacity is 63.2 percent, and compared with comparative examples 1 to 3 and comparative example 5, the traditional Chinese medicine extract plays a very important role in the antioxidation effect of the prepared skin care composition, especially the sage extract and the flaxseed extract; as can be seen from comparison with comparative example 4, the butter fruit is an important component of the skin care composition, and vitamin E, flavonoid and other substances contained in the butter fruit can neutralize free radicals and reduce damage of oxidative stress to skin cells. As can be seen from comparison with comparative example 6, the flaxseed is subjected to rasping and centrifugation at low temperature to maintain the activity of small molecules, and the rich unsaturated fatty acid can help reduce the generation of free radicals and prevent oxidative damage of cells. .
Test example 2 tyrosinase inhibition assay
2.1 Test methods
Taking human A375 melanocytes in logarithmic growth phase, regulating cell concentration to 5×10 4/mL with complete culture medium, inoculating into 96-well plate, adding 100 μl of skin care composition per well for continuous culture for 48 hr, and setting control group with blank complete culture medium and positive group with arbutin, and setting 3 multiple wells per well. After incubation to time node, PBS was washed 2 times, 10Triton X100 solution 90. Mu.L was added to each well, the cells were lysed by shaking for 5min, and 1% L of Dopa 10. Mu.L was added to each well after pre-incubation at 37 ℃. The tyrosinase activity was calculated as blank Kong Diaoling by measuring the absorbance (OD) at 490nm in a water bath at 37℃for 30 min.
2.2 Test results
As shown in table 2:
TABLE 2 tyrosinase activity
| Sequence number | Tyrosinase activity (%) |
| Example 3 | 43.2 |
| Comparative example 1 | 68.7 |
| Comparative example 2 | 62.1 |
| Comparative example 3 | 61.2 |
| Comparative example 4 | 60.5 |
| Comparative example 5 | 78.9 |
| Comparative example 6 | 50.2 |
| Blank group | 100 |
| Positive control group | 60.3 |
As can be seen from Table 2, example 3, comparative examples 1 to 6 and the positive control group have an inhibitory effect on tyrosine, wherein tyrosinase activity in example 3 is only 43.2%, indicating that the skin care composition prepared in example 3 has spot-removing ability.
Test example 3H 2O2 protection experiment against induced injury to HaCaT cells
3.1 Test methods
HaCaT cells are cultured by using a complete culture medium, logarithmic growth phase cells are inoculated into a 96-well plate according to 5X 10 4/mL, 100 mu L of each well is inoculated, after the cells are completely attached, the culture is continued for 4 hours by replacing the DMED culture medium containing 250 mu M hydrogen peroxide, the supernatant is discarded, PBS is used for three times, the culture is continued for 24 hours by adding the DMED complete culture medium containing the skin care composition, 4 mu g/mL of vitamin c is used as a positive control group, and distilled water is used as a control group. After incubation to time node, 10. Mu.L of CCK 8 was added to each well, incubated at 37℃for 20min, absorbance values of each well were measured at a wavelength of 450nm, and survival (%) of each well was calculated according to the following formula.
3.2 Test results
HaCaT cell viability is shown in table 3:
TABLE 3HaCaT cell viability
| Sequence number | HaCaT cell viability (%) |
| Example 3 | 90.1 |
| Comparative example 1 | 69.1 |
| Comparative example 2 | 75.5 |
| Comparative example 3 | 77.2 |
| Comparative example 4 | 74.0 |
| Comparative example 5 | 60.3 |
| Comparative example 6 | 82.1 |
| Blank group | 33.2 |
| Positive control group | 73.5 |
From table 3, it can be seen that the skin care composition has a better protection effect on HaCaT cells with H 2O2 induced oxidative damage, and the HaCaT cell survival rate of example 3 reaches 90.1%, which is significantly different from that of the positive control group, indicating that the skin care composition prepared in example 3 is more beneficial to resisting oxidative damage and aging effects of skin.
The foregoing description of the preferred embodiments of the invention is not intended to be limiting, but rather is intended to cover all modifications, equivalents, alternatives, and improvements that fall within the spirit and scope of the invention.
Claims (5)
1. The freckle-removing and anti-aging skin care composition is characterized by comprising the following raw materials in parts by weight: 5 to 10 parts of nicotinamide, 2 to 8 parts of polydimethylsiloxane, 2 to 8 parts of polysorbate-60, 25 to 65 parts of traditional Chinese medicine extract, 3 to 10 parts of butter fruit, 1 to 3 parts of hydroxypropyl cyclodextrin, 1 to 3 parts of tetrahydropyrimidine carboxylic acid, 1 to 5 parts of sodium hydroxide, 2 to 10 parts of cyclopeptide-161, 1 to 5 parts of acetyl tetrapeptide-11, 3 to 10 parts of hydroxypropyl tetrahydropyran triol, 3 to 7 parts of retinol, 1 to 5 parts of ascorbic acid, 2 to 9 parts of 3-o-ethyl ascorbic acid, 3 to 10 parts of sodium hyaluronate, 4 to 10 parts of astaxanthin, 5 to 10 parts of essence and 80 to 100 parts of water;
The traditional Chinese medicine extract comprises the following raw materials in parts by weight: 10-20 parts of gentian root extract, 5-15 parts of sage extract, 5-20 parts of lysimachia christinae hance extract and 5-10 parts of flaxseed extract;
the preparation method of the butter tree fruit fat comprises the following steps:
s1, cutting the avocado pulp into pieces, and grinding the pieces into powder by using liquid nitrogen;
s2, adding the avocado powder into an ethanol water solution with the concentration of 60-75 v/v% and the total volume of 3-7 times, and carrying out ultrasonic vibration extraction for 20-40 min;
s3, carrying out reflux extraction in a water bath at the extraction temperature of 40-60 ℃ for 20-30 min, carrying out suction filtration, centrifuging, filtering, evaporating and recovering ethanol to obtain crude extract of the fruit fat;
S4, preparing the crude extract of the fruit fat into a solution of 6-8 mg/ml, enabling the solution to flow through NKA-II macroporous adsorption resin at a flow rate of 2-4 BV/h for adsorption for 50-60 min, collecting effluent liquid, and concentrating to obtain the fruit fat of the Butyrospermum parkii;
the preparation method of the sage extract comprises the following steps:
S1, crushing stems and leaves of sage, adding an extracting solution with the total volume of 5-9 times, leaching for 60-80 min, and filtering with a microfiltration membrane to obtain a primary extract, wherein the extracting solution consists of water, galactosyl glyceride and mannitol according to the mass ratio of 10 (2-5) to 3-7;
S2, mixing and stirring the primary extract and isopropyl myristate for 10-20 min, and regulating the pH value to be neutral to obtain a sage extract;
the preparation method of the flaxseed extract comprises the following steps:
s1, cleaning fresh flaxseeds, putting the cleaned fresh flaxseeds into water, and filing the flaxseeds in the water, wherein the mass ratio of the flaxseeds to the water is 1 (5-15), and putting a water container into an ice water bath in the whole process to obtain a flaxseeds grinding liquid;
S2, adding 0.5-3 mol/L NaOH solution into the linseed grinding fluid to adjust the pH value to 8-11, and then adding alkaline protease accounting for 0.8-2% of the total mass and lipase accounting for 1-3% of the total mass for enzymolysis for 3-6 h;
S3, after the step S2 is finished, inactivating enzyme of the enzymolysis liquid in a water bath at the temperature of 90-98 ℃ for 20-30 min;
S4, placing the enzymatic hydrolysate after enzymatic hydrolysis at a preset temperature of 0-4 ℃ for refrigerated centrifugation, keeping the rotating speed at 8000-10000 r/min, collecting supernatant, filtering the supernatant by a filter element with the diameter of 0.3-0.6 mu m, and drying to obtain the flaxseed extract.
2. The freckle and anti-aging skin care composition according to claim 1, which is characterized by comprising the following raw materials in parts by weight: 8 parts of nicotinamide, 5 parts of polydimethylsiloxane, 5 parts of polysorbate-60, 48 parts of a traditional Chinese medicine extract, 8 parts of shea butter, 2 parts of hydroxypropyl cyclodextrin, 2 parts of tetrahydropyrimidine carboxylic acid, 2 parts of sodium hydroxide, 8 parts of cyclopeptide-161, 3 parts of acetyl tetrapeptide-11, 7 parts of hydroxypropyl tetrahydropyran triol, 5 parts of retinol, 4 parts of ascorbic acid, 6 parts of 3-o-ethyl ascorbic acid, 7 parts of sodium hyaluronate, 6 parts of astaxanthin, 6 parts of essence and 90 parts of water.
3. The freckle and anti-aging skin care composition according to claim 1, wherein the traditional Chinese medicine extract comprises the following raw materials in parts by weight: 15 parts of gentian extract, 10 parts of sage extract, 15 parts of desmodium extract and 8 parts of flaxseed extract.
4. The method of preparing a freckle and anti-aging skin care composition according to claim 1, comprising the steps of:
S1, adding nicotinamide, polydimethylsiloxane, polysorbate-60, tetrahydropyrimidine carboxylic acid, acetyl tetrapeptide-11, hydroxypropyl tetrahydropyran triol, retinol, ascorbic acid, 3-o-ethyl ascorbic acid and hydroxypropyl cyclodextrin into an emulsifying pot according to parts by weight, heating and continuously stirring to 70-80 ℃ until uniform and stable emulsion is formed, namely a component A;
s2, putting the traditional Chinese medicine extract, the fruit fat of the Butyrospermum parkii, the cyclic peptide-161, the essence and the water into a water phase pot according to parts by weight, heating and continuously stirring to 70-80 ℃ until the traditional Chinese medicine extract, the fruit fat of the Butyrospermum parkii, the cyclic peptide-161, the essence and the water are uniformly mixed, thus obtaining a component B;
And S3, stirring the component A at a stirring rate of 2000-3000 r/min, adding the component B while stirring, simultaneously adding sodium hyaluronate and astaxanthin, regulating the pH to 5-7 by using sodium hydroxide, naturally cooling to room temperature, and stopping stirring to obtain the skin care composition.
5. A spot-removing anti-aging skin care composition according to any one of claims 1 to 3, wherein the composition is one or more of a lotion, a skin cream, a cream concentrate, a body wash.
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