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IT1116037B - Esteri e ammidi di acil carnitine loro procedimenti di preparazione e loro uso terapeutico - Google Patents

Esteri e ammidi di acil carnitine loro procedimenti di preparazione e loro uso terapeutico

Info

Publication number
IT1116037B
IT1116037B IT48816/79A IT4881679A IT1116037B IT 1116037 B IT1116037 B IT 1116037B IT 48816/79 A IT48816/79 A IT 48816/79A IT 4881679 A IT4881679 A IT 4881679A IT 1116037 B IT1116037 B IT 1116037B
Authority
IT
Italy
Prior art keywords
amids
acil
therapeutic use
preparation procedures
carnitine esters
Prior art date
Application number
IT48816/79A
Other languages
English (en)
Other versions
IT7948816A0 (it
Original Assignee
Sigma Tau Ind Farmaceuti
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Ind Farmaceuti filed Critical Sigma Tau Ind Farmaceuti
Publication of IT7948816A0 publication Critical patent/IT7948816A0/it
Priority to IT48816/79A priority Critical patent/IT1116037B/it
Priority to GR61732A priority patent/GR68052B/el
Priority to GR61731A priority patent/GR68051B/el
Priority to IE800/80A priority patent/IE49700B1/en
Priority to IE801/80A priority patent/IE49701B1/en
Priority to ES490764A priority patent/ES8104191A1/es
Priority to SE8003005A priority patent/SE447244B/sv
Priority to LU82387A priority patent/LU82387A1/fr
Priority to LU82386A priority patent/LU82386A1/fr
Priority to ES490765A priority patent/ES8104987A1/es
Priority to AT0215680A priority patent/AT375336B/de
Priority to SE8003004A priority patent/SE448375B/sv
Priority to CH311080A priority patent/CH642849A5/it
Priority to DK170680A priority patent/DK170680A/da
Priority to NO801155A priority patent/NO151823C/no
Priority to DK170580A priority patent/DK155595C/da
Priority to AT0215780A priority patent/AT376656B/de
Priority to CH311180A priority patent/CH642619A5/it
Priority to NO801154A priority patent/NO151822C/no
Priority to DE19803015635 priority patent/DE3015635A1/de
Priority to JP5482280A priority patent/JPS562945A/ja
Priority to NL8002369A priority patent/NL8002369A/nl
Priority to BE0/200345A priority patent/BE882937A/fr
Priority to NL8002370A priority patent/NL8002370A/nl
Priority to FR8009149A priority patent/FR2455028A1/fr
Priority to AU57736/80A priority patent/AU538739B2/en
Priority to DE3015636A priority patent/DE3015636C2/de
Priority to GB8013428A priority patent/GB2051779B/en
Priority to BE0/200344A priority patent/BE882936A/fr
Priority to GB8013429A priority patent/GB2048268B/en
Priority to JP5482180A priority patent/JPS55167262A/ja
Priority to FR8009148A priority patent/FR2455027B1/fr
Priority to AU57738/80A priority patent/AU538740B2/en
Priority to IL59915A priority patent/IL59915A/xx
Priority to IL59914A priority patent/IL59914A/xx
Priority to US06/382,275 priority patent/US4443475A/en
Priority to US06/382,319 priority patent/US4439438A/en
Application granted granted Critical
Publication of IT1116037B publication Critical patent/IT1116037B/it
Priority to JP2267503A priority patent/JPH03236318A/ja

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/89—Carboxylic acid amides having nitrogen atoms of carboxamide groups quaternised
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IT48816/79A 1979-04-23 1979-04-23 Esteri e ammidi di acil carnitine loro procedimenti di preparazione e loro uso terapeutico IT1116037B (it)

Priority Applications (38)

Application Number Priority Date Filing Date Title
IT48816/79A IT1116037B (it) 1979-04-23 1979-04-23 Esteri e ammidi di acil carnitine loro procedimenti di preparazione e loro uso terapeutico
GR61732A GR68052B (it) 1979-04-23 1980-04-21
GR61731A GR68051B (it) 1979-04-23 1980-04-21
IE800/80A IE49700B1 (en) 1979-04-23 1980-04-21 Esters of acyl-carnitines,process for preparing same and pharmaceutical compositions containing such esters
IE801/80A IE49701B1 (en) 1979-04-23 1980-04-21 Amides of acyl-carnitines,process for preparing same and pharmaceutical compositions containing such amides
NO801154A NO151822C (no) 1979-04-23 1980-04-22 Analogifremgangsmaate ved fremstilling av terapeutisk aktive estere av acyl-carnitiner
SE8003005A SE447244B (sv) 1979-04-23 1980-04-22 Acylkarnitinamider, sett att framstella desamma samt farmaceutiska kompositioner innehallande desamma
LU82387A LU82387A1 (fr) 1979-04-23 1980-04-22 Esters d'acyl-carnitines,leur procede de preparation et compositions pharmaceutiques contenant ces esters
LU82386A LU82386A1 (fr) 1979-04-23 1980-04-22 Amides d'acyl-carnitines,leur procede de preparation et compositions pharmaceutiques contenant ces amides
ES490765A ES8104987A1 (es) 1979-04-23 1980-04-22 Procedimiento para preparar amidas de acil-carnitinas
AT0215680A AT375336B (de) 1979-04-23 1980-04-22 Verfahren zur herstellung von neuen estern von acylcarnitinhalogeniden
SE8003004A SE448375B (sv) 1979-04-23 1980-04-22 Estrar av acyl-karnitiner, sett att framstella desamma och farmaceutisk komposition innehallande sadana estrar
CH311080A CH642849A5 (it) 1979-04-23 1980-04-22 Ammidi di acil carnitine, procedimento per la loro preparazione e composizioni farmaceutiche che le contengono.
DK170680A DK170680A (da) 1979-04-23 1980-04-22 Fremgangsmaade til fremstilling af amider af acyl-carnitiner
NO801155A NO151823C (no) 1979-04-23 1980-04-22 Analogifremgangsmaate ved fremstilling av terapeutisk aktive amider av acyl-carnitiner
DK170580A DK155595C (da) 1979-04-23 1980-04-22 Analogifremgangsmaade til fremstilling af estere af acyl-carnitiner
AT0215780A AT376656B (de) 1979-04-23 1980-04-22 Verfahren zur herstellung von neuen amiden von acylcarnitinen
CH311180A CH642619A5 (it) 1979-04-23 1980-04-22 Esteri di acil carnitine, procedimento per la loro preparazione e composizioni farmaceutiche che li contengono.
ES490764A ES8104191A1 (es) 1979-04-23 1980-04-22 Procedimiento para preparar esteres de acil-carnitinas
BE0/200345A BE882937A (fr) 1979-04-23 1980-04-23 Esters d'acyl carnitines, leur preparation et leur utilisation
JP5482180A JPS55167262A (en) 1979-04-23 1980-04-23 Esters of carnitine* its manufacture and its use
NL8002369A NL8002369A (nl) 1979-04-23 1980-04-23 Amiden van acyl-carnitinen, werkwijze ter bereiding ervan en farmaceutische preparaten, die dergelijke amiden bevatten.
DE19803015635 DE3015635A1 (de) 1979-04-23 1980-04-23 Amide von acylcarnitinen, verfahren zu deren herstellung und diese enthaltende arzneimittel
NL8002370A NL8002370A (nl) 1979-04-23 1980-04-23 Esters van acyl-carnitinen, werkwijzen ter bereiding ervan en farmaceutische preparaten, die dergelijke esters bevatten.
FR8009149A FR2455028A1 (fr) 1979-04-23 1980-04-23 Nouveaux amides d'acylcarnitines, utiles notamment comme stimulants du systeme nerveux central, et leur procede de preparation
AU57736/80A AU538739B2 (en) 1979-04-23 1980-04-23 Esters of acyl-carnitines
DE3015636A DE3015636C2 (de) 1979-04-23 1980-04-23 Pharmazeutische Zubereitung auf der Grundlage von Carnitinestern mit inotroper Wirkung
GB8013428A GB2051779B (en) 1979-04-23 1980-04-23 Esters of acyl-carnitines
BE0/200344A BE882936A (fr) 1979-04-23 1980-04-23 Amides d'acyl carnitines, leur preparation et leur utilisation
GB8013429A GB2048268B (en) 1979-04-23 1980-04-23 Amides of acyl-carnitines process for preparing same and pharmaceutical compositions containing such amides
JP5482280A JPS562945A (en) 1979-04-23 1980-04-23 Amides of acylcarnitine and their manufacture and use
FR8009148A FR2455027B1 (fr) 1979-04-23 1980-04-23 Esters d'acylcarnitines utiles comme medicaments, leurs procedes de preparation et compositions therapeutiques les contenant
AU57738/80A AU538740B2 (en) 1979-04-23 1980-04-23 Amides of acyl-carnitines
IL59915A IL59915A (en) 1979-04-23 1980-04-24 Amides of acyl-carnitines,process for their preparation and pharmaceutical compositions containing them
IL59914A IL59914A (en) 1979-04-23 1980-04-24 Esters of acyl-carnitines,process for their preparation and pharmaceutical compositions containing them
US06/382,275 US4443475A (en) 1979-04-23 1982-05-26 Amides of acyl-carnitines, process for preparing same and pharmaceutical compositions containing such amides
US06/382,319 US4439438A (en) 1979-04-23 1982-05-26 Esters of acyl-carnitines, process for preparing same and pharmaceutical compositions containing such esters
JP2267503A JPH03236318A (ja) 1979-04-23 1990-10-03 抗うつ剤

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT48816/79A IT1116037B (it) 1979-04-23 1979-04-23 Esteri e ammidi di acil carnitine loro procedimenti di preparazione e loro uso terapeutico

Publications (2)

Publication Number Publication Date
IT7948816A0 IT7948816A0 (it) 1979-04-23
IT1116037B true IT1116037B (it) 1986-02-10

Family

ID=11268672

Family Applications (1)

Application Number Title Priority Date Filing Date
IT48816/79A IT1116037B (it) 1979-04-23 1979-04-23 Esteri e ammidi di acil carnitine loro procedimenti di preparazione e loro uso terapeutico

Country Status (19)

Country Link
US (2) US4443475A (it)
JP (3) JPS562945A (it)
AT (2) AT375336B (it)
AU (2) AU538739B2 (it)
BE (2) BE882936A (it)
CH (2) CH642619A5 (it)
DE (2) DE3015635A1 (it)
DK (2) DK155595C (it)
ES (2) ES8104191A1 (it)
FR (2) FR2455028A1 (it)
GB (2) GB2048268B (it)
GR (2) GR68052B (it)
IE (2) IE49701B1 (it)
IL (2) IL59915A (it)
IT (1) IT1116037B (it)
LU (2) LU82387A1 (it)
NL (2) NL8002369A (it)
NO (2) NO151823C (it)
SE (2) SE448375B (it)

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IT1120033B (it) 1979-10-05 1986-03-19 Sigma Tau Ind Farmaceuti Composizione farmaceutica comprendente-carnitina adatta per l'alimentazione parenterale
IT1144077B (it) * 1980-01-29 1986-10-29 Sigma Tau Ind Farmaceuti Carnitinammidi di amminoacidi otticamente attivi e procedimento per la loro preparazione
IT1147079B (it) * 1980-05-30 1986-11-19 Sigma Tau Ind Farmacuetiche Ri Esteri di alcossi-acil derivati della carnitina procedimento per la loro preparatione e composizioni farmaceutiche che li contengono
US4405642A (en) * 1980-11-28 1983-09-20 American Hospital Supply Corporation Method for treatment or prophylaxis of cardiac disorders
IT1170862B (it) * 1981-03-31 1987-06-03 Sigma Tau Ind Farmaceuti Mercaptoacil-carnitine procedimento per la loro preparazione e loro uso terapeutico
IT1170861B (it) * 1981-03-31 1987-06-03 Sigma Tau Ind Farmaceuti Ester di mercaptoacil-carnitine procedimento per la loro preparazione e loro uso terapeutico
IT1171360B (it) * 1981-07-03 1987-06-10 Sigma Tau Ind Farmaceuti Procedimento per la preparazione del cloruro acido di carnitina
IT1172127B (it) * 1981-12-03 1987-06-18 Sigma Tau Ind Farmaceuti Tioacil - carnitine procedimento per la loro preparazione e composizioni farmaceutiche che le contengono ad azione mucclitica
IT1177874B (it) * 1984-07-04 1987-08-26 Sigma Tau Ind Farmaceuti Estere della acetil carnitina,procedimenti per la sua preparazione e composizioni farmaceutiche che lo contengono
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US4897355A (en) 1985-01-07 1990-01-30 Syntex (U.S.A.) Inc. N[ω,(ω-1)-dialkyloxy]- and N-[ω,(ω-1)-dialkenyloxy]-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor
IT1201481B (it) * 1985-10-08 1989-02-02 Prodotti Antibiotici Spa Pantotenil derivati
US4866040A (en) * 1986-01-06 1989-09-12 Alfred Stracher Aminocarnitine directed pharmaceutical agents
US5008288A (en) * 1986-01-06 1991-04-16 Alfred Stracher Carnitine directed pharmaceutical agents
IT1224842B (it) * 1988-12-27 1990-10-24 Sigma Tau Ind Farmaceuti Uso di derivati della l-carnitina nel trattamento terapeutico delle alterazioni degenerative del sistema nervoso
IT1230141B (it) * 1989-05-03 1991-10-14 Fidia Spa Impiego di derivati della fosfatidil carnitina per la preparazione di composizioni farmaceutiche aventi attivita' nella terapia delle patologie dell'uomo associate con un danno neuronale.
IT1238344B (it) * 1989-10-20 1993-07-13 Sigma Tau Ind Farmaceuti Estere della l-carnitina con l'acido gamma-idrossibutirrico e composizioni farmaceutiche che lo contengono per l'inibizione della degenerazione neuronale e nel trattamento del coma
IT1240760B (it) * 1990-02-12 1993-12-17 Sigma Tau Ind Farmaceuti Esteri di acil-l-carnitine con l'acido gamma-idrossibutirrico e composizioni farmaceutiche che li contengono per l'inibizione della degenerazione neuronale e nel trattamento del coma.
IT1240775B (it) * 1990-02-23 1993-12-17 Sigma Tau Ind Farmaceuti Esteri della l-carnitina e di acil-l-carnitine con l'acido beta-idrossibutirrico e composizioni farmaceutiche che li contengono per la inibizione della degenerazione neuronale, della proteolisi epatica e nel trattamento del coma.
IT1240799B (it) * 1990-03-15 1993-12-17 Sigma Tau Ind Farmaceuti Composizioni farmaceutiche contenenti 3-metiltiopropionil l-carnitina ad attivita' sul sistema cardiovascolare.
EP0465984A1 (en) * 1990-07-04 1992-01-15 Matsushita Electric Industrial Co., Ltd. Photosensitive body used in electrophotography
IT1248323B (it) * 1991-05-16 1995-01-05 Sigma Tau Ind Farmaceuti Ammidi con amminoacidi naturali di alcanoil l-carnitine quali inibitori della degenerazione neuronale e attivatori dei processi di apprendimento e memorizzazione e per il trattamento del coma e composizioni farmaceutiche comprendenti tali composti
IT1254135B (it) * 1992-01-16 1995-09-08 Sigma Tau Ind Farmaceuti Esteri di acil carnitine con alcooli alifatici a lunga catena e composizioni farmaceutiche che li contengono, ad attivita' antibatterica.
IT1254136B (it) * 1992-01-16 1995-09-08 Sigma Tau Ind Farmaceuti Esteri di acil carnitine con alcooli alifatici a lunga catena e composizioni farmaceutiche che li contengono, ad attivita' antimicotica.
IT1258370B (it) * 1992-03-02 1996-02-26 Sigma Tau Ind Farmaceuti Esteri della l-carnitina e di acil l-carnitine dotati di attivita' miorilassante selettiva sull'apparato gastro-intestinale e composizioni farmaceutiche che li contengono.
IT1263013B (it) * 1992-10-20 1996-07-23 Avantgarde Spa Esteri della l-carnitina e di alcanoil l-carnitine con l'acido glicolico o suoi esteri e composizioni farmaceutiche contenenti tali per il trattamento di affezioni cutanee.
IT1261231B (it) * 1993-04-08 1996-05-09 Sigma Tau Ind Farmaceuti Procedimento migliorato per la preparazione di l-(-)-carnitina a partire da un prodotto di scarto avente opposta configurazione.
IT1261688B (it) * 1993-05-28 1996-05-29 Avantgarde Spa Uso di esteri sull'ossidrile della l-carnitina per produrre composizioni farmaceutiche per il trattamento di affezioni cutanee.
IT1261828B (it) * 1993-07-14 1996-06-03 Sigma Tau Ind Farmaceuti Esteri di acil l-carnitine e composizioni farmaceutiche che li contengono per il trattamento dello shock endotossico.
US5741816A (en) * 1994-06-20 1998-04-21 Tanabe Seiyaku Co., Ltd. Hair-growth agent
IT1299172B1 (it) * 1998-05-06 2000-02-29 Sigma Tau Ind Farmaceuti Esteri perfluorurati di alcanoil l-carnitine utilizzabili quali lipidi cationici per l'immissione intracellulare di composti
ITRM20020620A1 (it) * 2002-12-13 2004-06-14 Sigma Tau Ind Farmaceuti Uso delle carnitine per la prevenzione e/o il trattamento dei disturbi causati dall'andropausa.
ATE520717T1 (de) * 2003-05-21 2011-09-15 Basf Se Verfahren zur herstellung von estern des carnitins und ihre verwendung.
FI20030769A0 (fi) * 2003-05-21 2003-05-21 Raisio Chem Oy Tärkkelysjohdannaiset, niiden valmistus ja käyttö
US20050232911A1 (en) * 2004-04-19 2005-10-20 Schreiber Brian D Prevention and treatment of metabolic abnormalities associated with excess intramyocellular lipid
JP5485492B2 (ja) * 2004-12-15 2014-05-07 大正製薬株式会社 うつ病の予防・治療薬
JP2010513469A (ja) * 2006-12-20 2010-04-30 メドウェル ラボラトリーズ リミテッド ポリ不飽和脂肪酸とアミンの新規なコンジュゲート、およびその治療的使用
JP2011514809A (ja) * 2008-03-13 2011-05-12 パーキンエルマー ラス インコーポレイテッド 多重検出システムのための酵素基質
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CN102557972A (zh) * 2011-12-31 2012-07-11 南京海辰药业有限公司 氯化乙酰左卡尼汀的多晶型物
CN104161728A (zh) * 2013-05-17 2014-11-26 北京星昊医药股份有限公司 氯化丙酰左卡尼汀冻干粉针剂及其制备方法
CN104163769B (zh) * 2014-06-23 2016-06-15 海南霞迪药业有限公司 一种氯化丙酰左卡尼汀的制备方法

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Also Published As

Publication number Publication date
DK155595C (da) 1989-10-16
IE49701B1 (en) 1985-11-27
CH642849A5 (it) 1984-05-15
SE8003004L (sv) 1980-10-24
AU5773680A (en) 1980-10-30
FR2455028B1 (it) 1983-04-08
GR68052B (it) 1981-10-29
DE3015636A1 (de) 1980-11-06
ATA215780A (de) 1984-05-15
US4439438A (en) 1984-03-27
NO801154L (no) 1980-10-24
AU538740B2 (en) 1984-08-23
JPH03236318A (ja) 1991-10-22
DE3015635C2 (it) 1989-06-15
AU5773880A (en) 1980-10-30
LU82386A1 (fr) 1980-07-31
AT376656B (de) 1984-12-27
DE3015635A1 (de) 1980-11-13
ATA215680A (de) 1983-12-15
LU82387A1 (fr) 1980-07-31
GB2051779B (en) 1983-02-23
GB2051779A (en) 1981-01-21
ES490765A0 (es) 1981-05-16
IE800801L (en) 1980-10-23
ES8104987A1 (es) 1981-05-16
JPH0314810B2 (it) 1991-02-27
JPH0210821B2 (it) 1990-03-09
SE448375B (sv) 1987-02-16
IE800800L (en) 1980-10-23
SE447244B (sv) 1986-11-03
IE49700B1 (en) 1985-11-27
NO151822B (no) 1985-03-04
NL8002369A (nl) 1980-10-27
DE3015636C2 (de) 1993-10-21
AT375336B (de) 1984-07-25
IL59915A (en) 1984-04-30
DK170680A (da) 1980-10-24
BE882937A (fr) 1980-08-18
GR68051B (it) 1981-10-29
DK155595B (da) 1989-04-24
FR2455028A1 (fr) 1980-11-21
GB2048268A (en) 1980-12-10
US4443475A (en) 1984-04-17
BE882936A (fr) 1980-08-18
JPS562945A (en) 1981-01-13
AU538739B2 (en) 1984-08-23
GB2048268B (en) 1983-05-18
DK170580A (da) 1980-10-24
NO151823C (no) 1985-06-12
ES490764A0 (es) 1981-04-01
NO801155L (no) 1980-10-24
IL59914A (en) 1984-04-30
NO151822C (no) 1985-06-12
NL8002370A (nl) 1980-10-27
ES8104191A1 (es) 1981-04-01
FR2455027A1 (fr) 1980-11-21
FR2455027B1 (fr) 1985-08-09
JPS55167262A (en) 1980-12-26
CH642619A5 (it) 1984-04-30
IT7948816A0 (it) 1979-04-23
NO151823B (no) 1985-03-04
SE8003005L (sv) 1980-10-24

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