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ATA215780A - Verfahren zur herstellung von neuen amiden von acylcarnitinen - Google Patents

Verfahren zur herstellung von neuen amiden von acylcarnitinen

Info

Publication number
ATA215780A
ATA215780A AT0215780A AT215780A ATA215780A AT A215780 A ATA215780 A AT A215780A AT 0215780 A AT0215780 A AT 0215780A AT 215780 A AT215780 A AT 215780A AT A215780 A ATA215780 A AT A215780A
Authority
AT
Austria
Prior art keywords
acylcarnitines
producing new
new amides
amides
producing
Prior art date
Application number
AT0215780A
Other languages
English (en)
Other versions
AT376656B (de
Original Assignee
Sigma Tau Ind Farmaceuti
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Ind Farmaceuti filed Critical Sigma Tau Ind Farmaceuti
Publication of ATA215780A publication Critical patent/ATA215780A/de
Application granted granted Critical
Publication of AT376656B publication Critical patent/AT376656B/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/89—Carboxylic acid amides having nitrogen atoms of carboxamide groups quaternised
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT0215780A 1979-04-23 1980-04-22 Verfahren zur herstellung von neuen amiden von acylcarnitinen AT376656B (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT48816/79A IT1116037B (it) 1979-04-23 1979-04-23 Esteri e ammidi di acil carnitine loro procedimenti di preparazione e loro uso terapeutico

Publications (2)

Publication Number Publication Date
ATA215780A true ATA215780A (de) 1984-05-15
AT376656B AT376656B (de) 1984-12-27

Family

ID=11268672

Family Applications (2)

Application Number Title Priority Date Filing Date
AT0215680A AT375336B (de) 1979-04-23 1980-04-22 Verfahren zur herstellung von neuen estern von acylcarnitinhalogeniden
AT0215780A AT376656B (de) 1979-04-23 1980-04-22 Verfahren zur herstellung von neuen amiden von acylcarnitinen

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT0215680A AT375336B (de) 1979-04-23 1980-04-22 Verfahren zur herstellung von neuen estern von acylcarnitinhalogeniden

Country Status (19)

Country Link
US (2) US4443475A (de)
JP (3) JPS562945A (de)
AT (2) AT375336B (de)
AU (2) AU538739B2 (de)
BE (2) BE882936A (de)
CH (2) CH642619A5 (de)
DE (2) DE3015635A1 (de)
DK (2) DK155595C (de)
ES (2) ES8104191A1 (de)
FR (2) FR2455028A1 (de)
GB (2) GB2048268B (de)
GR (2) GR68052B (de)
IE (2) IE49701B1 (de)
IL (2) IL59915A (de)
IT (1) IT1116037B (de)
LU (2) LU82387A1 (de)
NL (2) NL8002369A (de)
NO (2) NO151823C (de)
SE (2) SE448375B (de)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1120033B (it) 1979-10-05 1986-03-19 Sigma Tau Ind Farmaceuti Composizione farmaceutica comprendente-carnitina adatta per l'alimentazione parenterale
IT1144077B (it) * 1980-01-29 1986-10-29 Sigma Tau Ind Farmaceuti Carnitinammidi di amminoacidi otticamente attivi e procedimento per la loro preparazione
IT1147079B (it) * 1980-05-30 1986-11-19 Sigma Tau Ind Farmacuetiche Ri Esteri di alcossi-acil derivati della carnitina procedimento per la loro preparatione e composizioni farmaceutiche che li contengono
US4405642A (en) * 1980-11-28 1983-09-20 American Hospital Supply Corporation Method for treatment or prophylaxis of cardiac disorders
IT1170862B (it) * 1981-03-31 1987-06-03 Sigma Tau Ind Farmaceuti Mercaptoacil-carnitine procedimento per la loro preparazione e loro uso terapeutico
IT1170861B (it) * 1981-03-31 1987-06-03 Sigma Tau Ind Farmaceuti Ester di mercaptoacil-carnitine procedimento per la loro preparazione e loro uso terapeutico
IT1171360B (it) * 1981-07-03 1987-06-10 Sigma Tau Ind Farmaceuti Procedimento per la preparazione del cloruro acido di carnitina
IT1172127B (it) * 1981-12-03 1987-06-18 Sigma Tau Ind Farmaceuti Tioacil - carnitine procedimento per la loro preparazione e composizioni farmaceutiche che le contengono ad azione mucclitica
IT1177874B (it) * 1984-07-04 1987-08-26 Sigma Tau Ind Farmaceuti Estere della acetil carnitina,procedimenti per la sua preparazione e composizioni farmaceutiche che lo contengono
US5550289A (en) * 1985-01-07 1996-08-27 Syntex (U.S.A.) Inc. N-(1,(1-1)-dialkyloxy)-and N-(1,(1-1)-dialkenyloxy alk-1-yl-N-N,N-tetrasubstituted ammonium lipids and uses therefor
US4897355A (en) 1985-01-07 1990-01-30 Syntex (U.S.A.) Inc. N[ω,(ω-1)-dialkyloxy]- and N-[ω,(ω-1)-dialkenyloxy]-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor
IT1201481B (it) * 1985-10-08 1989-02-02 Prodotti Antibiotici Spa Pantotenil derivati
US4866040A (en) * 1986-01-06 1989-09-12 Alfred Stracher Aminocarnitine directed pharmaceutical agents
US5008288A (en) * 1986-01-06 1991-04-16 Alfred Stracher Carnitine directed pharmaceutical agents
IT1224842B (it) * 1988-12-27 1990-10-24 Sigma Tau Ind Farmaceuti Uso di derivati della l-carnitina nel trattamento terapeutico delle alterazioni degenerative del sistema nervoso
IT1230141B (it) * 1989-05-03 1991-10-14 Fidia Spa Impiego di derivati della fosfatidil carnitina per la preparazione di composizioni farmaceutiche aventi attivita' nella terapia delle patologie dell'uomo associate con un danno neuronale.
IT1238344B (it) * 1989-10-20 1993-07-13 Sigma Tau Ind Farmaceuti Estere della l-carnitina con l'acido gamma-idrossibutirrico e composizioni farmaceutiche che lo contengono per l'inibizione della degenerazione neuronale e nel trattamento del coma
IT1240760B (it) * 1990-02-12 1993-12-17 Sigma Tau Ind Farmaceuti Esteri di acil-l-carnitine con l'acido gamma-idrossibutirrico e composizioni farmaceutiche che li contengono per l'inibizione della degenerazione neuronale e nel trattamento del coma.
IT1240775B (it) * 1990-02-23 1993-12-17 Sigma Tau Ind Farmaceuti Esteri della l-carnitina e di acil-l-carnitine con l'acido beta-idrossibutirrico e composizioni farmaceutiche che li contengono per la inibizione della degenerazione neuronale, della proteolisi epatica e nel trattamento del coma.
IT1240799B (it) * 1990-03-15 1993-12-17 Sigma Tau Ind Farmaceuti Composizioni farmaceutiche contenenti 3-metiltiopropionil l-carnitina ad attivita' sul sistema cardiovascolare.
EP0465984A1 (de) * 1990-07-04 1992-01-15 Matsushita Electric Industrial Co., Ltd. Lichtempfindlicher Körper verwendet in Elektrophotographie
IT1248323B (it) * 1991-05-16 1995-01-05 Sigma Tau Ind Farmaceuti Ammidi con amminoacidi naturali di alcanoil l-carnitine quali inibitori della degenerazione neuronale e attivatori dei processi di apprendimento e memorizzazione e per il trattamento del coma e composizioni farmaceutiche comprendenti tali composti
IT1254135B (it) * 1992-01-16 1995-09-08 Sigma Tau Ind Farmaceuti Esteri di acil carnitine con alcooli alifatici a lunga catena e composizioni farmaceutiche che li contengono, ad attivita' antibatterica.
IT1254136B (it) * 1992-01-16 1995-09-08 Sigma Tau Ind Farmaceuti Esteri di acil carnitine con alcooli alifatici a lunga catena e composizioni farmaceutiche che li contengono, ad attivita' antimicotica.
IT1258370B (it) * 1992-03-02 1996-02-26 Sigma Tau Ind Farmaceuti Esteri della l-carnitina e di acil l-carnitine dotati di attivita' miorilassante selettiva sull'apparato gastro-intestinale e composizioni farmaceutiche che li contengono.
IT1263013B (it) * 1992-10-20 1996-07-23 Avantgarde Spa Esteri della l-carnitina e di alcanoil l-carnitine con l'acido glicolico o suoi esteri e composizioni farmaceutiche contenenti tali per il trattamento di affezioni cutanee.
IT1261231B (it) * 1993-04-08 1996-05-09 Sigma Tau Ind Farmaceuti Procedimento migliorato per la preparazione di l-(-)-carnitina a partire da un prodotto di scarto avente opposta configurazione.
IT1261688B (it) * 1993-05-28 1996-05-29 Avantgarde Spa Uso di esteri sull'ossidrile della l-carnitina per produrre composizioni farmaceutiche per il trattamento di affezioni cutanee.
IT1261828B (it) * 1993-07-14 1996-06-03 Sigma Tau Ind Farmaceuti Esteri di acil l-carnitine e composizioni farmaceutiche che li contengono per il trattamento dello shock endotossico.
US5741816A (en) * 1994-06-20 1998-04-21 Tanabe Seiyaku Co., Ltd. Hair-growth agent
IT1299172B1 (it) * 1998-05-06 2000-02-29 Sigma Tau Ind Farmaceuti Esteri perfluorurati di alcanoil l-carnitine utilizzabili quali lipidi cationici per l'immissione intracellulare di composti
ITRM20020620A1 (it) * 2002-12-13 2004-06-14 Sigma Tau Ind Farmaceuti Uso delle carnitine per la prevenzione e/o il trattamento dei disturbi causati dall'andropausa.
ATE520717T1 (de) * 2003-05-21 2011-09-15 Basf Se Verfahren zur herstellung von estern des carnitins und ihre verwendung.
FI20030769A0 (fi) * 2003-05-21 2003-05-21 Raisio Chem Oy Tärkkelysjohdannaiset, niiden valmistus ja käyttö
US20050232911A1 (en) * 2004-04-19 2005-10-20 Schreiber Brian D Prevention and treatment of metabolic abnormalities associated with excess intramyocellular lipid
JP5485492B2 (ja) * 2004-12-15 2014-05-07 大正製薬株式会社 うつ病の予防・治療薬
JP2010513469A (ja) * 2006-12-20 2010-04-30 メドウェル ラボラトリーズ リミテッド ポリ不飽和脂肪酸とアミンの新規なコンジュゲート、およびその治療的使用
JP2011514809A (ja) * 2008-03-13 2011-05-12 パーキンエルマー ラス インコーポレイテッド 多重検出システムのための酵素基質
EP2216321A1 (de) * 2009-02-05 2010-08-11 Lonza Ltd. Verfahren zur Herstellung eines Fettsäuren- /Carnitinderivats
CN102557972A (zh) * 2011-12-31 2012-07-11 南京海辰药业有限公司 氯化乙酰左卡尼汀的多晶型物
CN104161728A (zh) * 2013-05-17 2014-11-26 北京星昊医药股份有限公司 氯化丙酰左卡尼汀冻干粉针剂及其制备方法
CN104163769B (zh) * 2014-06-23 2016-06-15 海南霞迪药业有限公司 一种氯化丙酰左卡尼汀的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE719891C (de) * 1938-12-08 1942-04-21 Dr Erich Strack Verfahren zur Herstellung des Methyl- bzw. AEthylesters des acetylierten Carnitins
US3968241A (en) * 1972-11-06 1976-07-06 Defelice Stephen L Method of treating cardiac arrhythmias and of improving myocardial contractility and systolic rhythm with carnitive or a pharmaceutically acceptable salt thereof
JPS531812B2 (de) * 1972-12-07 1978-01-23
JPS5058213A (de) * 1973-09-26 1975-05-21
US4032641A (en) * 1976-06-09 1977-06-28 Tanabe Seiyaku Co., Ltd. Nicotinoyl carnitine derivatives
AU518617B2 (en) * 1977-04-29 1981-10-08 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Therapeutic application of acetyl-d, 1-carnitine
IT1143611B (it) * 1977-11-03 1986-10-22 Sigma Tau Ind Farmaceuti Applicazione della acetil-carnitina nella terapia delle affezioni cardiache di/tipo anossico,ischemico,cardiotossico e nelle sindromi aritmiche
DE2903579A1 (de) * 1978-02-03 1979-08-09 Sigma Tau Ind Farmaceuti Verwendung von acetylcarnitin und anderen acylderivaten des carnitins zur behandlung der hyperlipoproteinaemie und hyperlimpidaemie sowie arzneimittel

Also Published As

Publication number Publication date
DK155595C (da) 1989-10-16
IE49701B1 (en) 1985-11-27
CH642849A5 (it) 1984-05-15
SE8003004L (sv) 1980-10-24
AU5773680A (en) 1980-10-30
FR2455028B1 (de) 1983-04-08
GR68052B (de) 1981-10-29
DE3015636A1 (de) 1980-11-06
US4439438A (en) 1984-03-27
NO801154L (no) 1980-10-24
AU538740B2 (en) 1984-08-23
JPH03236318A (ja) 1991-10-22
DE3015635C2 (de) 1989-06-15
AU5773880A (en) 1980-10-30
LU82386A1 (fr) 1980-07-31
AT376656B (de) 1984-12-27
DE3015635A1 (de) 1980-11-13
IT1116037B (it) 1986-02-10
ATA215680A (de) 1983-12-15
LU82387A1 (fr) 1980-07-31
GB2051779B (en) 1983-02-23
GB2051779A (en) 1981-01-21
ES490765A0 (es) 1981-05-16
IE800801L (en) 1980-10-23
ES8104987A1 (es) 1981-05-16
JPH0314810B2 (de) 1991-02-27
JPH0210821B2 (de) 1990-03-09
SE448375B (sv) 1987-02-16
IE800800L (en) 1980-10-23
SE447244B (sv) 1986-11-03
IE49700B1 (en) 1985-11-27
NO151822B (no) 1985-03-04
NL8002369A (nl) 1980-10-27
DE3015636C2 (de) 1993-10-21
AT375336B (de) 1984-07-25
IL59915A (en) 1984-04-30
DK170680A (da) 1980-10-24
BE882937A (fr) 1980-08-18
GR68051B (de) 1981-10-29
DK155595B (da) 1989-04-24
FR2455028A1 (fr) 1980-11-21
GB2048268A (en) 1980-12-10
US4443475A (en) 1984-04-17
BE882936A (fr) 1980-08-18
JPS562945A (en) 1981-01-13
AU538739B2 (en) 1984-08-23
GB2048268B (en) 1983-05-18
DK170580A (da) 1980-10-24
NO151823C (no) 1985-06-12
ES490764A0 (es) 1981-04-01
NO801155L (no) 1980-10-24
IL59914A (en) 1984-04-30
NO151822C (no) 1985-06-12
NL8002370A (nl) 1980-10-27
ES8104191A1 (es) 1981-04-01
FR2455027A1 (fr) 1980-11-21
FR2455027B1 (fr) 1985-08-09
JPS55167262A (en) 1980-12-26
CH642619A5 (it) 1984-04-30
IT7948816A0 (it) 1979-04-23
NO151823B (no) 1985-03-04
SE8003005L (sv) 1980-10-24

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
ELA Expired due to lapse of time