[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

IS4147A - Aðferð til framleiðslu á 1,5 Benzodiazepine afleiðum - Google Patents

Aðferð til framleiðslu á 1,5 Benzodiazepine afleiðum

Info

Publication number
IS4147A
IS4147A IS4147A IS4147A IS4147A IS 4147 A IS4147 A IS 4147A IS 4147 A IS4147 A IS 4147A IS 4147 A IS4147 A IS 4147A IS 4147 A IS4147 A IS 4147A
Authority
IS
Iceland
Prior art keywords
production
benzodiazepine derivatives
benzodiazepine
derivatives
Prior art date
Application number
IS4147A
Other languages
English (en)
Inventor
Finch Harry
Shah Pritom
Arthur Ellis Carr Robin
Original Assignee
Glaxo Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Inc filed Critical Glaxo Inc
Publication of IS4147A publication Critical patent/IS4147A/is

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08Tripeptides
    • C07K5/0821Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0207Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)4-C(=0), e.g. 'isosters', replacing two amino acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06139Dipeptides with the first amino acid being heterocyclic
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06191Dipeptides containing heteroatoms different from O, S, or N
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08Tripeptides
    • C07K5/0827Tripeptides containing heteroatoms different from O, S, or N
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Hydrogenated Pyridines (AREA)
IS4147A 1993-04-15 1994-04-11 Aðferð til framleiðslu á 1,5 Benzodiazepine afleiðum IS4147A (is)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB939307833A GB9307833D0 (en) 1993-04-15 1993-04-15 Modulators of cholecystokinin and gastrin

Publications (1)

Publication Number Publication Date
IS4147A true IS4147A (is) 1994-10-16

Family

ID=10733915

Family Applications (2)

Application Number Title Priority Date Filing Date
IS4147A IS4147A (is) 1993-04-15 1994-04-11 Aðferð til framleiðslu á 1,5 Benzodiazepine afleiðum
IS4148A IS4148A (is) 1993-04-15 1994-04-11 Hliðstæð aðferð til framleiðslu á 1,5 Benzodiazepine afleiðum

Family Applications After (1)

Application Number Title Priority Date Filing Date
IS4148A IS4148A (is) 1993-04-15 1994-04-11 Hliðstæð aðferð til framleiðslu á 1,5 Benzodiazepine afleiðum

Country Status (34)

Country Link
US (2) US5646140A (is)
EP (1) EP0694039B1 (is)
JP (1) JP3406317B2 (is)
KR (1) KR100364948B1 (is)
CN (1) CN1058487C (is)
AP (2) AP512A (is)
AT (1) ATE198894T1 (is)
AU (1) AU681139B2 (is)
CA (1) CA2158973C (is)
CZ (1) CZ286695B6 (is)
DE (1) DE69426624T2 (is)
DK (1) DK0694039T3 (is)
EC (1) ECSP941066A (is)
ES (1) ES2154674T3 (is)
FI (1) FI954853A (is)
GB (1) GB9307833D0 (is)
GR (1) GR3035641T3 (is)
HK (1) HK1003943A1 (is)
HU (1) HU223467B1 (is)
IL (2) IL109315A0 (is)
IS (2) IS4147A (is)
MY (2) MY112237A (is)
NO (1) NO311133B1 (is)
NZ (1) NZ265272A (is)
OA (1) OA10355A (is)
PE (2) PE50994A1 (is)
PH (1) PH30897A (is)
PL (1) PL178790B1 (is)
PT (1) PT694039E (is)
RU (1) RU2135486C1 (is)
SK (1) SK281211B6 (is)
TW (1) TW487703B (is)
WO (1) WO1994024149A1 (is)
ZA (2) ZA942571B (is)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3621416B2 (ja) * 1993-12-28 2005-02-16 塩野義製薬株式会社 新規なベンゾジアゼピン誘導体
US5739129A (en) * 1994-04-14 1998-04-14 Glaxo Wellcome Inc. CCK or gastrin modulating 5-heterocyclic-1, 5 benzodiazepines
TW369529B (en) * 1994-04-14 1999-09-11 Glaxo Inc 5-heterocyclo-1,5-benzodiazepine derivatives, pharmaceutical composition comprising the same and process for the preparation thereof
PE27497A1 (es) * 1994-04-15 1997-08-07 Glaxo Inc Derivados de 1,5 benzodiazepina
JPH09511998A (ja) * 1994-04-15 1997-12-02 グラクソ、ウェルカム、インコーポレーテッド 1,4 − ベンゾジアゼピン化合物を用いたコレシストキニンアゴニスト活性の誘導方法
US5780464A (en) * 1994-10-14 1998-07-14 Glaxo Wellcome Inc. Enteric coated compositions of 1,5-benzodiazepine derivatives having CCK antagonistic or agonistic activity
GB9420747D0 (en) * 1994-10-14 1994-11-30 Glaxo Inc 1,5 benzodiazepine derivatives
GB9420748D0 (en) * 1994-10-14 1994-11-30 Glaxo Inc 1,5 benzodiazepine derivatives
US5910495A (en) * 1994-10-14 1999-06-08 Glaxo Wellcome Inc. Use of 1,5-benzo b!1,4-diazepines to control gastric emptying
GB9420763D0 (en) * 1994-10-14 1994-11-30 Glaxo Inc Acetamide derivatives
US5750353A (en) * 1995-12-11 1998-05-12 New England Medical Center Hospitals, Inc. Assay for non-peptide agonists to peptide hormone receptors
WO1997021731A1 (en) 1995-12-11 1997-06-19 New England Medical Center Hospitals, Inc. Assay for and uses of peptide hormone receptor ligands
JP3999819B2 (ja) * 1996-12-10 2007-10-31 ゼリア新薬工業株式会社 1,5―ベンゾジアセピン誘導体
CN100378118C (zh) 1997-04-15 2008-04-02 Csir公司 具有食欲抑制剂活性的药物组合物
AR022044A1 (es) * 1999-05-06 2002-09-04 Glaxo Group Ltd Derivados de 1,5-benzodiazepina
GB2355657B (en) 1999-10-27 2004-07-28 Phytopharm Plc Inhibitors Of Gastric Acid Secretion
GB2363985B (en) 2000-06-30 2004-09-29 Phytopharm Plc Extracts,compounds & pharmaceutical compositions having anti-diabetic activity and their use
US6768024B1 (en) 2000-08-04 2004-07-27 Lion Bioscience Ag Triamine derivative melanocortin receptor ligands and methods of using same
US20020180095A1 (en) * 2001-05-29 2002-12-05 Berard Steven O. Thermally conductive carbon fiber extrusion compounder and method of using same
CA2476936A1 (en) * 2002-02-20 2003-08-28 Chih-Hung Lee Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (vr1) receptor
US7074805B2 (en) * 2002-02-20 2006-07-11 Abbott Laboratories Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor
US6933311B2 (en) * 2003-02-11 2005-08-23 Abbott Laboratories Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor
US7015233B2 (en) 2003-06-12 2006-03-21 Abbott Laboratories Fused compounds that inhibit vanilloid subtype 1 (VR1) receptor
CN1950374A (zh) * 2004-05-25 2007-04-18 辉瑞产品公司 四氮杂苯并[e]甘菊环衍生物及其类似物
CN1333077C (zh) * 2005-04-15 2007-08-22 华南农业大学 缩胆囊素活性片段的串联表达及其应用
CA2661898A1 (en) * 2006-08-25 2008-02-28 Abbott Laboratories Indazole derivatives that inhibit trpv1 and uses thereof
CN101563318A (zh) 2006-12-20 2009-10-21 艾博特公司 作为trpv1香草素受体拮抗剂用于治疗疼痛的n-(5,6,7,8-四氢萘-1-基)脲衍生物以及相关化合物
EP2323989A4 (en) * 2008-03-20 2011-06-22 Abbott Lab METHODS FOR PREPARING AGENTS FOR THE CENTRAL NERVOUS SYSTEM THAT ARE TRPV1 ANTAGONISTS
CN103102285B (zh) * 2013-01-30 2015-07-29 淮阴师范学院 对氨基苯乙腈的制备方法
RU2720237C2 (ru) 2013-11-18 2020-04-28 Форма Терапеутикс, Инк. Композиции, содержащие бензопиперазин, в качестве ингибиторов бромодоменов вет
BR112016011024B1 (pt) 2013-11-18 2020-09-01 Forma Therapeutics, Inc Composto, composição farmacêutica, e, usos dos mesmos
NZ739226A (en) 2015-07-22 2022-11-25 Enanta Pharm Inc Benzodiazepine derivatives as rsv inhibitors
EP3414239A2 (en) 2016-02-05 2018-12-19 Denali Therapeutics Inc. Inhibitors of receptor-interacting protein kinase 1
PL3552017T3 (pl) 2016-12-09 2022-08-08 Denali Therapeutics Inc. Związki użyteczne jako inhibitory RIPK1
MX2019009687A (es) 2017-02-16 2019-12-18 Enanta Pharm Inc Procesos para la preparación de derivados de benzodiazepina.
US10752598B2 (en) * 2017-06-07 2020-08-25 Enanta Pharmaceuticals, Inc. Aryldiazepine derivatives as RSV inhibitors
US10851115B2 (en) 2017-06-30 2020-12-01 Enanta Pharmaceuticals, Inc. Heterocyclic compounds as RSV inhibitors
WO2019006295A1 (en) 2017-06-30 2019-01-03 Enanta Pharmaceuticals, Inc. HETEROCYCLIC COMPOUNDS AS RSV INHIBITORS
CA3077309A1 (en) 2017-09-29 2019-04-04 Enanta Pharmaceuticals, Inc. Combination pharmaceutical agents as rsv inhibitors
US10647711B2 (en) 2017-11-13 2020-05-12 Enanta Pharmaceuticals, Inc. Azepin-2-one derivatives as RSV inhibitors
WO2019199908A1 (en) 2018-04-11 2019-10-17 Enanta Pharmaceuticals, Inc. Heterocyclic compounds as rsv inhibitors
KR20210138684A (ko) 2019-03-18 2021-11-19 이난타 파마슈티칼스, 인코포레이티드 Rsv 억제제로서의 벤조디아제핀 유도체
WO2020210246A1 (en) 2019-04-09 2020-10-15 Enanta Pharmaceuticals, Inc, Heterocyclic compounds as rsv inhibitors
US11505558B1 (en) 2019-10-04 2022-11-22 Enanta Pharmaceuticals, Inc. Antiviral heterocyclic compounds
UY39032A (es) 2020-01-24 2021-07-30 Enanta Pharm Inc Compuestos heterocíclicos como agentes antivirales
US11534439B2 (en) 2020-07-07 2022-12-27 Enanta Pharmaceuticals, Inc. Dihydroquinoxaline and dihydropyridopyrazine derivatives as RSV inhibitors
WO2022086840A1 (en) 2020-10-19 2022-04-28 Enanta Pharmaceuticals, Inc. Heterocyclic compounds as anti-viral agents
MX2024008648A (es) 2022-01-12 2024-09-23 Denali Therapeutics Inc Formas cristalinas de (s)-5-bencil-n-(5-metil-4-oxo-2,3,4,5-tetrah idropirido [3,2- b][1,4]oxacepin-3-il)-4h-1,2,4-triazol-3-carboxam ida.

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2641280B1 (fr) * 1988-12-29 1994-01-21 Roussel Uclaf Nouveaux derives de la 2,4-dioxo 2,3,4,5-tetrahydro 1h-1,5-benzodiazepine, leur procede de preparation et leur application comme medicaments
FR2659653B1 (fr) * 1990-03-13 1992-05-22 Rhone Poulenc Sante Derives de l'uree, leur preparation et les medicaments les contenant.
US5206234A (en) * 1990-10-22 1993-04-27 Merck & Co., Inc. Benzolactam analogs as antagonists of cck
JP2904941B2 (ja) * 1991-01-28 1999-06-14 出光興産株式会社 スチレン系重合体の精製方法
GEP20001968B (en) * 1992-01-21 2000-03-05 Glaxo Spa Arilthio Compounds as Antibacterial and Antiviral Agents
TW369529B (en) * 1994-04-14 1999-09-11 Glaxo Inc 5-heterocyclo-1,5-benzodiazepine derivatives, pharmaceutical composition comprising the same and process for the preparation thereof

Also Published As

Publication number Publication date
CA2158973C (en) 2006-06-06
FI954853A0 (fi) 1995-10-12
ATE198894T1 (de) 2001-02-15
CZ267595A3 (en) 1996-04-17
DE69426624D1 (de) 2001-03-01
MY131569A (en) 2007-08-30
AU6567694A (en) 1994-11-08
JPH08508744A (ja) 1996-09-17
ZA942571B (en) 1994-11-11
AP9400634A0 (en) 1994-04-30
AP512A (en) 1996-07-29
SK281211B6 (sk) 2001-01-18
IS4148A (is) 1994-10-16
ECSP941066A (es) 1994-11-16
NO311133B1 (no) 2001-10-15
EP0694039A1 (en) 1996-01-31
NO954090D0 (no) 1995-10-13
US5585376A (en) 1996-12-17
AP9400635A0 (en) 1994-04-30
MY112237A (en) 2001-05-31
AP462A (en) 1996-02-19
CZ286695B6 (en) 2000-06-14
FI954853A (fi) 1995-10-12
CA2158973A1 (en) 1994-10-27
NO954090L (no) 1995-12-13
RU2135486C1 (ru) 1999-08-27
US5646140A (en) 1997-07-08
HU9502978D0 (en) 1995-12-28
PT694039E (pt) 2001-06-29
PL311084A1 (en) 1996-02-05
HK1003943A1 (en) 1998-11-13
JP3406317B2 (ja) 2003-05-12
OA10355A (en) 2001-10-19
PL178790B1 (pl) 2000-06-30
IL109316A (en) 1999-03-12
CN1058487C (zh) 2000-11-15
DE69426624T2 (de) 2001-06-21
KR100364948B1 (ko) 2003-03-29
GR3035641T3 (en) 2001-06-29
HU223467B1 (hu) 2004-07-28
PH30897A (en) 1997-12-23
DK0694039T3 (da) 2001-05-21
IL109315A0 (en) 1994-07-31
GB9307833D0 (en) 1993-06-02
PE50594A1 (es) 1995-01-06
SK125395A3 (en) 1996-06-05
ZA942570B (en) 1994-11-11
NZ265272A (en) 1997-07-27
CN1120843A (zh) 1996-04-17
ES2154674T3 (es) 2001-04-16
WO1994024149A1 (en) 1994-10-27
TW487703B (en) 2002-05-21
EP0694039B1 (en) 2001-01-24
AU681139B2 (en) 1997-08-21
HUT74102A (en) 1996-11-28
IL109316A0 (en) 1994-07-31
PE50994A1 (es) 1995-01-06

Similar Documents

Publication Publication Date Title
IS4147A (is) Aðferð til framleiðslu á 1,5 Benzodiazepine afleiðum
IS4201A (is) Aðferð til framleiðslu á Benzofuran afleiðum
IS3970A (is) Hliðstæð aðferð til framleiðslu á 1,5-benzódíazepín afleiðum
IS4121A (is) Hliðstæð aðferð til framleiðslu á 2,6-Díamínópúrín afleiðum
IS3915A (is) Aðferð til framleiðslu á benzanilíð afleiðum
IS3914A (is) Aðferð til framleiðslu á benzanilíð afleiðum
MX9206450A (es) Proceso para la produccion de isoleucina-l.
IS3994A (is) Hliðstæð aðferð til framleiðslu á indole afleiðum
NO992860D0 (no) FremgangsmÕte for fremstilling av hydrokarboner
NO981800L (no) FremgangsmÕte for fremstilling av 1,1,1,3,3-pentafluorpentan
HUP9901285A3 (en) Process for the production of difluoromethane
IS4219A (is) Aðferð til framleiðslu á Indole afleiðum
IS3827A (is) Hliðstæð aðferð við framleiðslu á pýrról[2,3 b]pýridínum
IS5209A (is) Aðferð til framleiðslu á pýrazóló[4,3-d]pýrimidín-7-ónum og milliefnum af því
GR3032600T3 (en) Process for the production of imidazo-benzodiazepine derivatives
NO950487D0 (no) Fremgangsmåte for fremstilling av hydrogen
IS4190A (is) Hliðstæð aðferð til framleiðslu á 1,5 bensódíasepín afleiðum
HUP9904096A3 (en) Process for the production of substituted phenylpyridines
ZA985918B (en) Process for the production of indole derivatives.
NO985535D0 (no) FremgangsmÕte for fremstilling av 1,3-alkandioler
FI960332A (fi) Menetelmä substituoitujan 4,6-diamino-5-syanopyrinidiinien valmistamiseksi
FR2686898B1 (fr) Methode de production de la l-phenylalanine.
IS2201B (is) Aðferð til framleiðslu á handhverfu auðguðum N-afleiddum laktömum
IS4707A (is) Aðferð til framleiðslu á díoxóazabísýklóhexönum
ZA924595B (en) Process for the production of 1-(n)-acetyl-3,5,7-trinitrocyclotetramethylenetetramine