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DK0694039T3 - Derivater af 1,5-benzodiazepin med CCK-antagonistisk og agonistisk virkning - Google Patents

Derivater af 1,5-benzodiazepin med CCK-antagonistisk og agonistisk virkning

Info

Publication number
DK0694039T3
DK0694039T3 DK94913580T DK94913580T DK0694039T3 DK 0694039 T3 DK0694039 T3 DK 0694039T3 DK 94913580 T DK94913580 T DK 94913580T DK 94913580 T DK94913580 T DK 94913580T DK 0694039 T3 DK0694039 T3 DK 0694039T3
Authority
DK
Denmark
Prior art keywords
benzodiazepine
derivatives
agonistic effect
cck
antagonistic
Prior art date
Application number
DK94913580T
Other languages
English (en)
Inventor
Elizabeth Ellen Sugg
Christopher Joseph Aquino
Jerzy Ryszard Szewczyk
Harry Finch
Robin Arthur Ellis Carr
Original Assignee
Glaxo Wellcome Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Wellcome Inc filed Critical Glaxo Wellcome Inc
Application granted granted Critical
Publication of DK0694039T3 publication Critical patent/DK0694039T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08Tripeptides
    • C07K5/0821Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0207Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)4-C(=0), e.g. 'isosters', replacing two amino acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06139Dipeptides with the first amino acid being heterocyclic
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06191Dipeptides containing heteroatoms different from O, S, or N
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08Tripeptides
    • C07K5/0827Tripeptides containing heteroatoms different from O, S, or N
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Hydrogenated Pyridines (AREA)
DK94913580T 1993-04-15 1994-04-14 Derivater af 1,5-benzodiazepin med CCK-antagonistisk og agonistisk virkning DK0694039T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB939307833A GB9307833D0 (en) 1993-04-15 1993-04-15 Modulators of cholecystokinin and gastrin
PCT/EP1994/001131 WO1994024149A1 (en) 1993-04-15 1994-04-14 1,5-benzodiazepine derivatives having cck antagonistic or agonistic activity

Publications (1)

Publication Number Publication Date
DK0694039T3 true DK0694039T3 (da) 2001-05-21

Family

ID=10733915

Family Applications (1)

Application Number Title Priority Date Filing Date
DK94913580T DK0694039T3 (da) 1993-04-15 1994-04-14 Derivater af 1,5-benzodiazepin med CCK-antagonistisk og agonistisk virkning

Country Status (34)

Country Link
US (2) US5646140A (da)
EP (1) EP0694039B1 (da)
JP (1) JP3406317B2 (da)
KR (1) KR100364948B1 (da)
CN (1) CN1058487C (da)
AP (2) AP462A (da)
AT (1) ATE198894T1 (da)
AU (1) AU681139B2 (da)
CA (1) CA2158973C (da)
CZ (1) CZ286695B6 (da)
DE (1) DE69426624T2 (da)
DK (1) DK0694039T3 (da)
EC (1) ECSP941066A (da)
ES (1) ES2154674T3 (da)
FI (1) FI954853A (da)
GB (1) GB9307833D0 (da)
GR (1) GR3035641T3 (da)
HK (1) HK1003943A1 (da)
HU (1) HU223467B1 (da)
IL (2) IL109315A0 (da)
IS (2) IS4148A (da)
MY (2) MY112237A (da)
NO (1) NO311133B1 (da)
NZ (1) NZ265272A (da)
OA (1) OA10355A (da)
PE (2) PE50994A1 (da)
PH (1) PH30897A (da)
PL (1) PL178790B1 (da)
PT (1) PT694039E (da)
RU (1) RU2135486C1 (da)
SK (1) SK281211B6 (da)
TW (1) TW487703B (da)
WO (1) WO1994024149A1 (da)
ZA (2) ZA942571B (da)

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CN1073089C (zh) * 1993-12-28 2001-10-17 盐野义制药株式会社 苯并二氮杂噁衍生物、其组合物及其在药物制备中的用途
US5739129A (en) * 1994-04-14 1998-04-14 Glaxo Wellcome Inc. CCK or gastrin modulating 5-heterocyclic-1, 5 benzodiazepines
BR9507381A (pt) * 1994-04-14 1997-09-23 Glaxo Wellcome Inc Composto uso de um composto processo para o tratamento de um manifero composição famacèutica e processo para a preparação de compostos
PE27497A1 (es) * 1994-04-15 1997-08-07 Glaxo Inc Derivados de 1,5 benzodiazepina
US5795887A (en) * 1994-04-15 1998-08-18 Glaxo Wellcome Inc. Method of inducing cholecystokinin agonist activity using 1,4- Benzodiazepine compounds
GB9420763D0 (en) * 1994-10-14 1994-11-30 Glaxo Inc Acetamide derivatives
GB9420747D0 (en) * 1994-10-14 1994-11-30 Glaxo Inc 1,5 benzodiazepine derivatives
US5910495A (en) * 1994-10-14 1999-06-08 Glaxo Wellcome Inc. Use of 1,5-benzo b!1,4-diazepines to control gastric emptying
US5780464A (en) * 1994-10-14 1998-07-14 Glaxo Wellcome Inc. Enteric coated compositions of 1,5-benzodiazepine derivatives having CCK antagonistic or agonistic activity
GB9420748D0 (en) * 1994-10-14 1994-11-30 Glaxo Inc 1,5 benzodiazepine derivatives
US5750353A (en) * 1995-12-11 1998-05-12 New England Medical Center Hospitals, Inc. Assay for non-peptide agonists to peptide hormone receptors
JP4442930B2 (ja) 1995-12-11 2010-03-31 タフツ メディカル センター インコーポレイテッド ペプチドホルモンレセプターリガンドに関するアッセイ法およびその使用
WO1998025911A1 (fr) * 1996-12-10 1998-06-18 Zeria Pharmaceutical Co., Ltd. Derives de 1,5-benzodiazepine
SK141899A3 (en) 1997-04-15 2000-09-12 Csir Corporate Building Pharmaceutical compositions having appetite suppressant activity
AR022044A1 (es) * 1999-05-06 2002-09-04 Glaxo Group Ltd Derivados de 1,5-benzodiazepina
GB2355657B (en) 1999-10-27 2004-07-28 Phytopharm Plc Inhibitors Of Gastric Acid Secretion
GB2363985B (en) 2000-06-30 2004-09-29 Phytopharm Plc Extracts,compounds & pharmaceutical compositions having anti-diabetic activity and their use
US6768024B1 (en) 2000-08-04 2004-07-27 Lion Bioscience Ag Triamine derivative melanocortin receptor ligands and methods of using same
US20020180095A1 (en) * 2001-05-29 2002-12-05 Berard Steven O. Thermally conductive carbon fiber extrusion compounder and method of using same
US7074805B2 (en) * 2002-02-20 2006-07-11 Abbott Laboratories Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor
ATE420644T1 (de) * 2002-02-20 2009-01-15 Abbott Lab Kondensierte azabicyclischeverbindungen als inhibitoren des vanilloid-rezeptors 1 (vr1)
US6933311B2 (en) * 2003-02-11 2005-08-23 Abbott Laboratories Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor
US7015233B2 (en) * 2003-06-12 2006-03-21 Abbott Laboratories Fused compounds that inhibit vanilloid subtype 1 (VR1) receptor
CA2568056A1 (en) * 2004-05-25 2005-12-08 Pfizer Products Inc. Tetraazabenzo[e]azulene derivatives and analogs thereof
CN1333077C (zh) * 2005-04-15 2007-08-22 华南农业大学 缩胆囊素活性片段的串联表达及其应用
WO2008024945A1 (en) * 2006-08-25 2008-02-28 Abbott Laboratories Indazole derivatives that inhibit trpv1 and uses thereof
CA2672196A1 (en) 2006-12-20 2008-07-03 Abbott Laboratories Antagonists of the trpv1 receptor and uses thereof
EP2489660A1 (en) * 2008-03-20 2012-08-22 Abbott Laboratories Methods for making central nervous system agents that are TRPV1 antagonists
CN103102285B (zh) * 2013-01-30 2015-07-29 淮阴师范学院 对氨基苯乙腈的制备方法
PL3071203T3 (pl) 2013-11-18 2021-08-23 Forma Therapeutics, Inc. Kompozycje tetrahydrochinolinowe jako inhibitory bromodomeny bet
CN106029076B (zh) 2013-11-18 2019-06-07 福马疗法公司 作为bet溴域抑制剂的苯并哌嗪组合物
US9957281B2 (en) 2015-07-22 2018-05-01 Enanta Pharmaceuticals, Inc. Benzodiazepine derivatives as RSV inhibitors
CR20180413A (es) 2016-02-05 2018-12-04 Denali Therapeutics Inc Inhibidores de la proteína quinasa 1 que interactua con el receptor
CN110383066B (zh) 2016-12-09 2023-03-31 戴纳立制药公司 化合物、组合物和方法
JP7076459B2 (ja) 2017-02-16 2022-05-27 エナンタ ファーマシューティカルズ インコーポレイテッド ベンゾジアゼピン誘導体の製造プロセス
US10752598B2 (en) * 2017-06-07 2020-08-25 Enanta Pharmaceuticals, Inc. Aryldiazepine derivatives as RSV inhibitors
US11091501B2 (en) 2017-06-30 2021-08-17 Enanta Pharmaceuticals, Inc. Heterocyclic compounds as RSV inhibitors
WO2019006291A1 (en) 2017-06-30 2019-01-03 Enanta Pharmaceuticals, Inc. HETEROCYCLIC COMPOUNDS AS RSV INHIBITORS
CA3077309A1 (en) 2017-09-29 2019-04-04 Enanta Pharmaceuticals, Inc. Combination pharmaceutical agents as rsv inhibitors
US10647711B2 (en) 2017-11-13 2020-05-12 Enanta Pharmaceuticals, Inc. Azepin-2-one derivatives as RSV inhibitors
WO2019199908A1 (en) 2018-04-11 2019-10-17 Enanta Pharmaceuticals, Inc. Heterocyclic compounds as rsv inhibitors
AU2020240024A1 (en) 2019-03-18 2021-10-14 Enanta Pharmaceuticals, Inc. Benzodiazepine derivatives as RSV inhibitors
WO2020210246A1 (en) 2019-04-09 2020-10-15 Enanta Pharmaceuticals, Inc, Heterocyclic compounds as rsv inhibitors
US11505558B1 (en) 2019-10-04 2022-11-22 Enanta Pharmaceuticals, Inc. Antiviral heterocyclic compounds
UY39032A (es) 2020-01-24 2021-07-30 Enanta Pharm Inc Compuestos heterocíclicos como agentes antivirales
WO2022010882A1 (en) 2020-07-07 2022-01-13 Enanta Pharmaceuticals, Inc, Dihydroquinoxaline and dihydropyridopyrazine derivatives as rsv inhibitors
WO2022086840A1 (en) 2020-10-19 2022-04-28 Enanta Pharmaceuticals, Inc. Heterocyclic compounds as anti-viral agents
KR20240132504A (ko) 2022-01-12 2024-09-03 데날리 테라퓨틱스 인크. (s)-5-벤질-n-(5-메틸-4-옥소-2,3,4,5-테트라하이드로피리도 [3,2-b][1,4]옥사제핀-3-일)-4h-1,2,4-트리아졸-3-카복사미드의 결정질 형태

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FR2641280B1 (fr) * 1988-12-29 1994-01-21 Roussel Uclaf Nouveaux derives de la 2,4-dioxo 2,3,4,5-tetrahydro 1h-1,5-benzodiazepine, leur procede de preparation et leur application comme medicaments
FR2659653B1 (fr) * 1990-03-13 1992-05-22 Rhone Poulenc Sante Derives de l'uree, leur preparation et les medicaments les contenant.
US5206234A (en) * 1990-10-22 1993-04-27 Merck & Co., Inc. Benzolactam analogs as antagonists of cck
JP2904941B2 (ja) * 1991-01-28 1999-06-14 出光興産株式会社 スチレン系重合体の精製方法
GEP20001968B (en) * 1992-01-21 2000-03-05 Glaxo Spa Arilthio Compounds as Antibacterial and Antiviral Agents
BR9507381A (pt) * 1994-04-14 1997-09-23 Glaxo Wellcome Inc Composto uso de um composto processo para o tratamento de um manifero composição famacèutica e processo para a preparação de compostos

Also Published As

Publication number Publication date
PE50994A1 (es) 1995-01-06
PL178790B1 (pl) 2000-06-30
NO954090L (no) 1995-12-13
SK281211B6 (sk) 2001-01-18
AU681139B2 (en) 1997-08-21
NO311133B1 (no) 2001-10-15
AP9400635A0 (en) 1994-04-30
MY131569A (en) 2007-08-30
IS4147A (is) 1994-10-16
DE69426624T2 (de) 2001-06-21
AP9400634A0 (en) 1994-04-30
PH30897A (en) 1997-12-23
PE50594A1 (es) 1995-01-06
JPH08508744A (ja) 1996-09-17
ATE198894T1 (de) 2001-02-15
EP0694039A1 (en) 1996-01-31
DE69426624D1 (de) 2001-03-01
CN1058487C (zh) 2000-11-15
HU9502978D0 (en) 1995-12-28
US5585376A (en) 1996-12-17
CZ286695B6 (en) 2000-06-14
KR100364948B1 (ko) 2003-03-29
US5646140A (en) 1997-07-08
IL109316A0 (en) 1994-07-31
FI954853A0 (fi) 1995-10-12
AU6567694A (en) 1994-11-08
CA2158973A1 (en) 1994-10-27
HUT74102A (en) 1996-11-28
ZA942571B (en) 1994-11-11
NO954090D0 (no) 1995-10-13
CZ267595A3 (en) 1996-04-17
CN1120843A (zh) 1996-04-17
PL311084A1 (en) 1996-02-05
MY112237A (en) 2001-05-31
ECSP941066A (es) 1994-11-16
AP512A (en) 1996-07-29
WO1994024149A1 (en) 1994-10-27
GB9307833D0 (en) 1993-06-02
ZA942570B (en) 1994-11-11
JP3406317B2 (ja) 2003-05-12
HU223467B1 (hu) 2004-07-28
AP462A (en) 1996-02-19
RU2135486C1 (ru) 1999-08-27
PT694039E (pt) 2001-06-29
NZ265272A (en) 1997-07-27
FI954853A (fi) 1995-10-12
HK1003943A1 (en) 1998-11-13
IL109316A (en) 1999-03-12
OA10355A (en) 2001-10-19
GR3035641T3 (en) 2001-06-29
TW487703B (en) 2002-05-21
CA2158973C (en) 2006-06-06
IL109315A0 (en) 1994-07-31
IS4148A (is) 1994-10-16
SK125395A3 (en) 1996-06-05
ES2154674T3 (es) 2001-04-16
EP0694039B1 (en) 2001-01-24

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