IL99443A0 - Heterocyclic derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same - Google Patents
Heterocyclic derivatives,processes for the preparation thereof and pharmaceutical compositions containing the sameInfo
- Publication number
- IL99443A0 IL99443A0 IL99443A IL9944391A IL99443A0 IL 99443 A0 IL99443 A0 IL 99443A0 IL 99443 A IL99443 A IL 99443A IL 9944391 A IL9944391 A IL 9944391A IL 99443 A0 IL99443 A0 IL 99443A0
- Authority
- IL
- Israel
- Prior art keywords
- alkyl
- processes
- preparation
- pharmaceutical compositions
- hydrogen
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 150000002431 hydrogen Chemical class 0.000 abstract 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000004442 acylamino group Chemical group 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000002883 imidazolyl group Chemical group 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB909020838A GB9020838D0 (en) | 1990-09-25 | 1990-09-25 | Condensed imidazole derivatives and process for preparation thereof |
| GB909023467A GB9023467D0 (en) | 1990-10-29 | 1990-10-29 | Condensed imidazole derivatives and process for preparation thereof |
| GB909028216A GB9028216D0 (en) | 1990-12-31 | 1990-12-31 | Condensed imidazole derivatives and process for preparation thereof |
| GB919103874A GB9103874D0 (en) | 1991-02-25 | 1991-02-25 | Heterocyclic derivatives |
| GB919106956A GB9106956D0 (en) | 1991-04-03 | 1991-04-03 | Heterocyclic derivatives |
| GB919107231A GB9107231D0 (en) | 1991-04-05 | 1991-04-05 | Heterocyclic derivatives |
| GB919112803A GB9112803D0 (en) | 1991-06-14 | 1991-06-14 | Heterocyclic derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL99443A0 true IL99443A0 (en) | 1992-08-18 |
Family
ID=27562836
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL99443A IL99443A0 (en) | 1990-09-25 | 1991-09-08 | Heterocyclic derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US5210092A (ja) |
| EP (1) | EP0480204B1 (ja) |
| JP (1) | JPH04288075A (ja) |
| KR (1) | KR920006347A (ja) |
| CN (1) | CN1059723A (ja) |
| AT (1) | ATE135701T1 (ja) |
| AU (1) | AU650473B2 (ja) |
| CA (1) | CA2052125A1 (ja) |
| DE (1) | DE69118082T2 (ja) |
| FI (1) | FI914163A (ja) |
| HU (1) | HUT59404A (ja) |
| IE (1) | IE913164A1 (ja) |
| IL (1) | IL99443A0 (ja) |
| NO (1) | NO913750L (ja) |
| PT (1) | PT99038A (ja) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5177074A (en) * | 1991-03-26 | 1993-01-05 | Merck & Co., Inc. | Angiotensin ii antagonists incorporating a substituted thiophene or furan |
| TW274551B (ja) * | 1991-04-16 | 1996-04-21 | Takeda Pharm Industry Co Ltd | |
| US5252574A (en) * | 1991-04-26 | 1993-10-12 | Merck & Co., Inc. | Angiotensin II antagonists incorporating a substituted thiophene or furan |
| US5198438A (en) * | 1991-05-07 | 1993-03-30 | Merck & Co., Inc. | Angiotensin ii antagonists incorporating a substituted thiophene or furan |
| US5354759A (en) * | 1991-09-12 | 1994-10-11 | Fujisawa Pharmaceutical Co., Ltd. | Angiotenin II antagonizing heterocyclic compounds |
| WO1993019067A1 (en) * | 1991-09-12 | 1993-09-30 | Fujisawa Pharmaceutical Co., Ltd. | Imidazopyridine derivatives as angiotensin ii antagonists |
| GB9201789D0 (en) * | 1992-01-28 | 1992-03-11 | Fujisawa Pharmaceutical Co | Heterocyclic derivatives |
| US5283242A (en) * | 1991-10-24 | 1994-02-01 | American Home Products Corporation | Substituted benzimidazoles and quinazolines as antihypertensives |
| JPH07507271A (ja) * | 1992-03-03 | 1995-08-10 | 藤沢薬品工業株式会社 | アンジオテンシン１１拮抗剤としてのベンズイミダゾール誘導体 |
| US5364869A (en) * | 1992-03-09 | 1994-11-15 | Abbott Laboratories | Heterocycle-substituted benzyaminopyridine angiotensin II receptor antagonists |
| EP0577025A3 (de) * | 1992-07-01 | 1998-02-04 | Hoechst Aktiengesellschaft | Angiotensin-II-Rezeptorantagonisten zur Behandlung und Prophylaxe von koronaren Herzerkrankungen |
| EP0577023A3 (en) * | 1992-07-01 | 1996-12-18 | Hoechst Ag | Angiotensin-ii receptor-antagonists for the treatment of arrhythmices |
| GB9218449D0 (en) | 1992-08-29 | 1992-10-14 | Boots Co Plc | Therapeutic agents |
| WO1994005633A1 (en) * | 1992-09-01 | 1994-03-17 | Ciba-Geigy Ag | 3-cyano-4-halogeno-2-(subst.phenyl)-pyrroles as pesticides and fungicides |
| DE69328108D1 (de) * | 1992-10-13 | 2000-04-20 | Searle & Co | N-arylheteroarylalkyl-1-phenyl-imidazol-2-on verbindungen bei der behandlung von zirkulatorischen störungen |
| DE4236026A1 (de) * | 1992-10-24 | 1994-04-28 | Merck Patent Gmbh | Imidazopyridine |
| US5376666A (en) * | 1992-11-30 | 1994-12-27 | The Du Pont Merck Pharmaceutical Company | Angiotension-II receptor blocking, azacycloalkyl or azacycloalkenyl |
| DE69332736T2 (de) * | 1992-12-07 | 2004-03-25 | Eisai Co., Ltd. | Verfahren zur herstellung von imidazopyridinderivaten und zwischenprodukte |
| US5455260A (en) * | 1993-05-21 | 1995-10-03 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Aliphatic amino bis-aryl squalene synthase inhibitors |
| US5338740A (en) * | 1993-07-13 | 1994-08-16 | Pfizer Inc. | Angiotensin II receptor antagonists |
| ATE318799T1 (de) * | 1995-06-07 | 2006-03-15 | Nippon Shinyaku Co Ltd | Pyrrolderivate und medizinische zubereitung. |
| HRP980375A2 (en) | 1997-07-03 | 1999-04-30 | Argyrios Georgios Arvanitis | Imidazopyrimidines and imidazopyridines for the treatment of neurological disorders |
| US6365589B1 (en) | 1998-07-02 | 2002-04-02 | Bristol-Myers Squibb Pharma Company | Imidazo-pyridines, -pyridazines, and -triazines as corticotropin releasing factor antagonists |
| US6124463A (en) * | 1998-07-02 | 2000-09-26 | Dupont Pharmaceuticals | Benzimidazoles as corticotropin release factor antagonists |
| SE9903028D0 (sv) | 1999-08-27 | 1999-08-27 | Astra Ab | New use |
| US7781478B2 (en) | 2004-07-14 | 2010-08-24 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
| US7868037B2 (en) | 2004-07-14 | 2011-01-11 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
| WO2006019831A1 (en) | 2004-07-14 | 2006-02-23 | Ptc Therapeutics, Inc. | Methods for treating hepatitis c |
| US7772271B2 (en) | 2004-07-14 | 2010-08-10 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
| EP1781289A1 (en) | 2004-07-22 | 2007-05-09 | PTC Therapeutics, Inc. | Thienopyridines for treating hepatitis c |
| US7531560B2 (en) * | 2004-11-10 | 2009-05-12 | Boehringer Ingelheim Pharmaceuticals, Inc. | Anti-cytokine heterocyclic compounds |
| PE20070341A1 (es) * | 2005-07-29 | 2007-04-13 | Wyeth Corp | Derivados de pirrol como moduladores del receptor de progesterona |
| PE20070182A1 (es) * | 2005-07-29 | 2007-03-06 | Wyeth Corp | Derivados cianopirrol-fenil amida como moduladores del receptor de progesterona |
| US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
| JP5546451B2 (ja) | 2007-06-04 | 2014-07-09 | シナジー ファーマシューティカルズ インコーポレイテッド | 胃腸の障害、炎症、癌および他の障害の処置に有用なグアニル酸シクラーゼのアゴニスト |
| EP2810951B1 (en) | 2008-06-04 | 2017-03-15 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| AR072297A1 (es) | 2008-06-27 | 2010-08-18 | Novartis Ag | Derivados de indol-2-il-piridin-3-ilo, composicion farmaceutica que los comprende y su uso en medicamentos para el tratamiento de enfermedades mediadas por la sintasa aldosterona. |
| EP3241839B1 (en) | 2008-07-16 | 2019-09-04 | Bausch Health Ireland Limited | Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders |
| US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
| WO2012174164A2 (en) | 2011-06-15 | 2012-12-20 | Metabolex, Inc. | Agonists of gpr131 and uses thereof |
| US9593109B2 (en) | 2011-08-26 | 2017-03-14 | Cymabay Therapeutics, Inc. | Bicyclic agonists of GPR131 and uses thereof |
| US8889730B2 (en) | 2012-04-10 | 2014-11-18 | Pfizer Inc. | Indole and indazole compounds that activate AMPK |
| JP2016514671A (ja) | 2013-03-15 | 2016-05-23 | シナジー ファーマシューティカルズ インコーポレイテッド | グアニル酸シクラーゼのアゴニストおよびその使用 |
| CA2905242C (en) | 2013-03-15 | 2016-11-29 | Pfizer Inc. | Indole compounds that activate ampk |
| EP2968439A2 (en) | 2013-03-15 | 2016-01-20 | Synergy Pharmaceuticals Inc. | Compositions useful for the treatment of gastrointestinal disorders |
| EP4424697A2 (en) | 2013-06-05 | 2024-09-04 | Bausch Health Ireland Limited | Ultra-pure agonists of guanylate cyclase c, method of making and using same |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3130251A1 (de) * | 1981-07-31 | 1983-02-17 | A. Nattermann & Cie GmbH, 5000 Köln | 6-(4-((omega)-(1-imidazolyl)-alkyl)-phenyl)-3-oxo -2,3,4,5-tetrahydro-pyridazine und deren saeureadditionssalze, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate |
| CA1338238C (en) * | 1988-01-07 | 1996-04-09 | David John Carini | Angiotensin ii receptor blocking imidazoles and combinations thereof with diuretics and nsaids |
| US4916129A (en) * | 1989-01-19 | 1990-04-10 | E. I. Du Pont De Nemours And Company | Combination β-blocking/angiotensin II blocking antihypertensives |
| IE64514B1 (en) * | 1989-05-23 | 1995-08-09 | Zeneca Ltd | Azaindenes |
| IL94390A (en) * | 1989-05-30 | 1996-03-31 | Merck & Co Inc | The 6-membered trans-nitrogen-containing heterocycles are compressed with imidazo and pharmaceutical preparations containing them |
| IL96019A0 (en) * | 1989-10-31 | 1991-07-18 | Fujisawa Pharmaceutical Co | Imidazole derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same |
| TW300219B (ja) * | 1991-09-14 | 1997-03-11 | Hoechst Ag |
-
1991
- 1991-08-23 US US07/748,954 patent/US5210092A/en not_active Expired - Fee Related
- 1991-08-30 AU AU83454/91A patent/AU650473B2/en not_active Ceased
- 1991-09-04 FI FI914163A patent/FI914163A/fi not_active Application Discontinuation
- 1991-09-08 IL IL99443A patent/IL99443A0/xx unknown
- 1991-09-09 IE IE316491A patent/IE913164A1/en unknown
- 1991-09-14 DE DE69118082T patent/DE69118082T2/de not_active Expired - Fee Related
- 1991-09-14 EP EP91115644A patent/EP0480204B1/en not_active Expired - Lifetime
- 1991-09-14 AT AT91115644T patent/ATE135701T1/de not_active IP Right Cessation
- 1991-09-24 PT PT99038A patent/PT99038A/pt not_active Application Discontinuation
- 1991-09-24 NO NO91913750A patent/NO913750L/no unknown
- 1991-09-24 JP JP3317589A patent/JPH04288075A/ja active Pending
- 1991-09-24 CA CA002052125A patent/CA2052125A1/en not_active Abandoned
- 1991-09-24 HU HU913052A patent/HUT59404A/hu unknown
- 1991-09-24 CN CN91109182A patent/CN1059723A/zh active Pending
- 1991-09-24 KR KR1019910016597A patent/KR920006347A/ko not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| FI914163A0 (fi) | 1991-09-04 |
| AU8345491A (en) | 1992-04-02 |
| US5210092A (en) | 1993-05-11 |
| CN1059723A (zh) | 1992-03-25 |
| FI914163A (fi) | 1992-03-26 |
| DE69118082D1 (de) | 1996-04-25 |
| ATE135701T1 (de) | 1996-04-15 |
| NO913750L (no) | 1992-03-26 |
| HUT59404A (en) | 1992-05-28 |
| CA2052125A1 (en) | 1992-03-26 |
| IE913164A1 (en) | 1992-02-25 |
| JPH04288075A (ja) | 1992-10-13 |
| AU650473B2 (en) | 1994-06-23 |
| EP0480204A1 (en) | 1992-04-15 |
| HU913052D0 (en) | 1992-01-28 |
| EP0480204B1 (en) | 1996-03-20 |
| PT99038A (pt) | 1992-08-31 |
| NO913750D0 (no) | 1991-09-24 |
| KR920006347A (ko) | 1992-04-27 |
| DE69118082T2 (de) | 1996-10-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| HC | Change of name of proprietor(s) |