IL44415A - Vinblastine and leurocristine carboxamide derivatives - Google Patents

Vinblastine and leurocristine carboxamide derivatives

Info

Publication number: IL44415A
Authority: IL; Israel
Prior art keywords: leurocristine; vinblastine; carboxamide derivatives; carboxamide; derivatives
Prior art date: 1973-04-02

Application number

IL44415A

Other languages

English (en)

Other versions

IL44415A0 (en

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1973-04-02

Filing date

1974-03-13

Publication date

1978-08-31

1974-03-13 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

1974-06-30 Publication of IL44415A0 publication Critical patent/IL44415A0/xx

1978-08-31 Publication of IL44415A publication Critical patent/IL44415A/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Oncology (AREA)
Hematology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Fodder In General (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

IL44415A 1973-04-02 1974-03-13 Vinblastine and leurocristine carboxamide derivatives IL44415A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US34727573A	1973-04-02	1973-04-02

Publications (2)

Publication Number	Publication Date
IL44415A0 IL44415A0 (en)	1974-06-30
IL44415A true IL44415A (en)	1978-08-31

Family

ID=23363051

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL44415A IL44415A (en)	1973-04-02	1974-03-13	Vinblastine and leurocristine carboxamide derivatives

Country Status (28)

Country	Link
JP (2)	JPS5919117B2 (ru)
AR (2)	AR204004A1 (ru)
AT (1)	AT340605B (ru)
BE (1)	BE813168A (ru)
BG (3)	BG21235A3 (ru)
CA (1)	CA1042428A (ru)
CH (1)	CH603669A5 (ru)
CS (1)	CS185223B2 (ru)
CY (1)	CY1044A (ru)
DD (1)	DD113538A5 (ru)
DE (1)	DE2415980A1 (ru)
DK (1)	DK141511B (ru)
ES (2)	ES424882A1 (ru)
FR (1)	FR2223044B1 (ru)
GB (1)	GB1463575A (ru)
HK (1)	HK20180A (ru)
HU (1)	HU171572B (ru)
IE (1)	IE39071B1 (ru)
IL (1)	IL44415A (ru)
KE (1)	KE3028A (ru)
MY (1)	MY8100025A (ru)
NL (1)	NL181079C (ru)
PH (1)	PH13623A (ru)
RO (2)	RO77533A (ru)
SE (1)	SE416206B (ru)
SU (4)	SU731900A3 (ru)
YU (3)	YU39719B (ru)
ZA (1)	ZA741674B (ru)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL48685A (en) *	1975-01-09	1980-03-31	Lilly Co Eli	Amides of vincadioline and vinblastine
GR69783B (ru) *	1976-09-08	1982-07-07	Lilly Co Eli
USRE30561E (en)	1976-12-06	1981-03-31	Eli Lilly And Company	Vinca alkaloid intermediates
US4096148A (en) *	1976-12-06	1978-06-20	Eli Lilly And Company	Oxazolidinedione derivatives of Vinca alkaloids
USRE30560E (en) *	1976-12-06	1981-03-31	Eli Lilly And Company	Oxazolidinedione derivatives of Vinca alkaloids
US4203898A (en)	1977-08-29	1980-05-20	Eli Lilly And Company	Amide derivatives of VLB, leurosidine, leurocristine and related dimeric alkaloids
US4199504A (en) *	1978-05-15	1980-04-22	Eli Lilly And Company	Bridged cathranthus alkaloid dimers
US4357334A (en)	1980-03-20	1982-11-02	Eli Lilly And Company	Use of VLB 3-(2-chloroethyl) carboxamide in treating neoplasms
LU83822A1 (fr) *	1981-12-08	1983-09-01	Omnichem Sa	Derives n-(vinblastinoyl-23)d'acides amines,leur preparation et leur application therapeutique
OA06421A (fr) *	1980-06-10	1981-09-30	Omnium Chimique Sa	Procédé de préparation de dérivés N-(vinblastinoyl-23) d'acides aminés et de peptides.
FR2623504B1 (fr) *	1987-11-25	1990-03-09	Adir	Nouveaux derives n-(vinblastinoyl-23) d'acide amino-1 methylphosphonique, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
HUT76925A (hu) *	1995-04-04	1998-01-28	MTA Enzimológiai Intézet	Bisz-indol-származékok, eljárás előállításukra és az azokat tartalmazó gyógyszerkészítmények
US5948750A (en) *	1996-10-30	1999-09-07	Merck & Co., Inc.	Conjugates useful in the treatment of prostate cancer
US6326402B1 (en)	1998-08-12	2001-12-04	Octamer, Inc.	Methods for treating viral infections using a compound capable of inhibiting microtubules
EP1845974A1 (en)	2005-01-21	2007-10-24	Astex Therapeutics Limited	Pharmaceutical compounds
US7405227B2 (en)	2005-07-18	2008-07-29	Bipar Sciences, Inc.	Treatment of cancer
EP2061479A4 (en)	2006-09-05	2010-08-04	Bipar Sciences Inc	FETTIC ACID SYNTHESIS INHIBITED BY PARP HEMMER AND TREATMENT PROCEDURES THEREWITH
EP2059498A4 (en)	2006-09-05	2011-01-12	Bipar Sciences Inc	TREATMENT OF CANCER
US8916552B2 (en)	2006-10-12	2014-12-23	Astex Therapeutics Limited	Pharmaceutical combinations
JP5528807B2 (ja)	2006-10-12	2014-06-25	アステックス、セラピューティックス、リミテッド	複合薬剤
EP2217227B1 (en)	2007-11-12	2013-08-21	BiPar Sciences, Inc.	Treatment of breast cancer with 4-iodo-3-nitrobenzamide in combination with anti-tumor agents
JP6250710B2 (ja) *	2013-04-19	2017-12-20	曁南大学	ビンブラスチン誘導体の調製方法
CN113456797B (zh) *	2021-06-18	2024-03-08	暨南大学	长春碱类衍生物在制备治疗骨肉瘤和/或软组织肉瘤药物中的应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3097137A (en) *	1960-05-19	1963-07-09	Canadian Patents Dev	Vincaleukoblastine

1974
- 1974-01-01 AR AR253105A patent/AR204004A1/es active
- 1974-03-13 IE IE532/74A patent/IE39071B1/xx unknown
- 1974-03-13 IL IL44415A patent/IL44415A/xx unknown
- 1974-03-13 ZA ZA00741674A patent/ZA741674B/xx unknown
- 1974-03-22 CA CA195,760A patent/CA1042428A/en not_active Expired
- 1974-03-25 YU YU817/74A patent/YU39719B/xx unknown
- 1974-03-25 CY CY1044A patent/CY1044A/xx unknown
- 1974-03-25 GB GB1310174A patent/GB1463575A/en not_active Expired
- 1974-03-29 CH CH446374A patent/CH603669A5/xx not_active IP Right Cessation
- 1974-03-29 PH PH15676A patent/PH13623A/en unknown
- 1974-03-29 FR FR7411519A patent/FR2223044B1/fr not_active Expired
- 1974-04-01 SU SU742013753A patent/SU731900A3/ru active
- 1974-04-01 HU HU74EI00000538A patent/HU171572B/hu unknown
- 1974-04-01 DK DK178774AA patent/DK141511B/da not_active IP Right Cessation
- 1974-04-01 SE SE7404380A patent/SE416206B/xx not_active IP Right Cessation
- 1974-04-01 CS CS7400002335A patent/CS185223B2/cs unknown
- 1974-04-01 AT AT267974A patent/AT340605B/de not_active IP Right Cessation
- 1974-04-01 NL NLAANVRAGE7404423,A patent/NL181079C/xx not_active IP Right Cessation
- 1974-04-02 BE BE1005847A patent/BE813168A/xx not_active IP Right Cessation
- 1974-04-02 RO RO7498695A patent/RO77533A/ro unknown
- 1974-04-02 ES ES424882A patent/ES424882A1/es not_active Expired
- 1974-04-02 BG BG028514A patent/BG21235A3/xx unknown
- 1974-04-02 BG BG028513A patent/BG21612A3/xx unknown
- 1974-04-02 RO RO78274A patent/RO73524B/ro unknown
- 1974-04-02 DE DE2415980A patent/DE2415980A1/de active Granted
- 1974-04-02 DD DD177632A patent/DD113538A5/xx unknown
- 1974-04-02 JP JP49037765A patent/JPS5919117B2/ja not_active Expired
- 1974-04-02 BG BG026279A patent/BG22831A3/xx unknown
1975
- 1975-01-08 AR AR257228A patent/AR203882A1/es active
- 1975-07-04 SU SU752151512A patent/SU784783A3/ru active
- 1975-07-09 SU SU752152020A patent/SU652896A3/ru active
1976
- 1976-03-31 ES ES446571A patent/ES446571A1/es not_active Expired
- 1976-12-20 SU SU762429453A patent/SU623522A3/ru active
1980
- 1980-02-27 KE KE3028A patent/KE3028A/xx unknown
- 1980-04-17 HK HK201/80A patent/HK20180A/xx unknown
- 1980-04-25 YU YU1139/80A patent/YU39876B/xx unknown
- 1980-04-25 YU YU1138/80A patent/YU39875B/xx unknown
1981
- 1981-12-30 MY MY25/81A patent/MY8100025A/xx unknown
1983
- 1983-12-16 JP JP58238722A patent/JPS6033837B2/ja not_active Expired

Also Published As

Publication number	Publication date
SU731900A3 (ru)	1980-04-30
DE2415980C2 (ru)	1989-11-09
IL44415A0 (en)	1974-06-30
IE39071L (en)	1974-10-02
CY1044A (en)	1980-08-01
DK141511B (da)	1980-04-08
NL181079B (nl)	1987-01-16
RO73524A (ro)	1984-10-31
YU39719B (en)	1985-04-30
JPS49128000A (ru)	1974-12-07
BG21612A3 (bg)	1976-07-20
SU652896A3 (ru)	1979-03-15
YU39876B (en)	1985-04-30
AR203882A1 (es)	1975-10-31
AR204004A1 (es)	1975-11-12
HU171572B (hu)	1978-02-28
NL181079C (nl)	1987-06-16
DD113538A5 (ru)	1975-06-12
BE813168A (fr)	1974-10-02
JPS6033837B2 (ja)	1985-08-05
PH13623A (en)	1980-08-07
YU81774A (en)	1982-05-31
NL7404423A (ru)	1974-10-04
CS185223B2 (en)	1978-09-15
RO73524B (ro)	1984-11-30
MY8100025A (en)	1981-12-31
JPS5919117B2 (ja)	1984-05-02
ATA267974A (de)	1977-04-15
RO77533A (ro)	1982-02-01
ES424882A1 (es)	1976-12-16
BG22831A3 (bg)	1977-04-20
JPS59193895A (ja)	1984-11-02
HK20180A (en)	1980-04-25
SE416206B (sv)	1980-12-08
DK141511C (ru)	1980-09-29
FR2223044B1 (ru)	1978-06-30
SU623522A3 (ru)	1978-09-05
GB1463575A (en)	1977-02-02
YU113880A (en)	1982-05-31
SU784783A3 (ru)	1980-11-30
YU39875B (en)	1985-04-30
KE3028A (en)	1980-03-28
DE2415980A1 (de)	1974-10-10
ES446571A1 (es)	1977-06-16
FR2223044A1 (ru)	1974-10-25
BG21235A3 (bg)	1976-03-20
AU6671974A (en)	1975-09-18
ZA741674B (en)	1975-10-29
CH603669A5 (ru)	1978-08-31
IE39071B1 (en)	1978-08-02
YU113980A (en)	1982-05-31
AT340605B (de)	1977-12-27
CA1042428A (en)	1978-11-14

Publication	Publication Date	Title
IL44415A0 (en)	1974-06-30	Vinblastine and leurocristine carboxamide derivatives
PH11743A (en)	1978-05-30	Fluoroakoxyphenyl-substituted nitrogen heterocycles
CY969A (en)	1978-12-22	2-anilino-nicotinic and derivatives
HK53980A (en)	1980-10-03	Vincamine derivatives
KE2912A (en)	1979-01-26	Vincamine and apovincamine derivatives
HK8978A (en)	1978-02-24	Triazolo-isoindole and triazolo-isoquinoline derivatives and their manufacture and uses
NZ182426A (en)	1978-11-13	Aroyl-phenylindene and aroyl-phenyl-naphthalene derivatives
IL50436A (en)	1980-01-31	4-halomethyl-or hydroxymethyl-2-pyrrolidinone and 4-aminomethyl-tetrahydrofuran-2-one derivatives and their production
AU458569B2 (en)	1975-02-27	Dioxocin carboxamide derivatives
ZA747664B (en)	1976-01-28	Quinoline derivatives
IL44400A0 (en)	1974-06-30	Imidazothiazole and imidazothiazine derivatives
AU8556275A (en)	1977-04-21	Vinblastine derivatives
IL44842A (en)	1978-08-31	3 alkylamino-2-hydroxy-propoxy-phthalide and isochromanone derivatives
IL45877A (en)	1979-09-30	4-oxo-1-pyridinyl-penicillin and cephalosporin derivatives
JPS5227747A (en)	1977-03-02	New epoxycyclohexene and derivatives thereof
ZM11874A1 (en)	1975-03-21	Benzo and benzothiopyranoindazole n-oxide
JPS5223074A (en)	1977-02-21	Hexahydroo2hhindazole derivatives and production thereof
ZA765347B (en)	1977-09-28	Orgotein derivatives and their production
MW4074A1 (en)	1976-01-14	Cepham derivatives and preparation thereof
JPS5225774A (en)	1977-02-25	2133benzothiazole derivatives and production thereof
IL44958A (en)	1978-09-29	Mercaptoalkylpyridines and derivatives
ZA743814B (en)	1976-01-28	Mercaptoalkylpyridines and derivatives
AU482431B2 (en)	1977-04-21	Novel amide derivatives of vlb and leurocristine
CU21074A3 (es)	1988-02-15	derivados peptidiccos
ZA734705B (en)	1974-06-26	Substituted alkonoic acids and derivatives