YU81774A - Process for preparing new derivatives of vinblastin and leurocrystin - Google Patents

Process for preparing new derivatives of vinblastin and leurocrystin

Info

Publication number: YU81774A
Authority: YU; Yugoslavia
Prior art keywords: leurocrystin; vinblastin; new derivatives; preparing new; preparing
Prior art date: 1973-04-02

Application number

YU00817/74A

Other versions

YU39719B (en

Inventor

G J Cullinam

K Gerzon

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1973-04-02

Filing date

1974-03-25

Publication date

1982-05-31

1974-03-25 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

1982-05-31 Publication of YU81774A publication Critical patent/YU81774A/en

1985-04-30 Publication of YU39719B publication Critical patent/YU39719B/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Oncology (AREA)
Hematology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Fodder In General (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

YU817/74A 1973-04-02 1974-03-25 Process for obtaining new derivatives of vinbastine and leurocristine YU39719B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US34727573A	1973-04-02	1973-04-02

Publications (2)

Publication Number	Publication Date
YU81774A true YU81774A (en)	1982-05-31
YU39719B YU39719B (en)	1985-04-30

Family

ID=23363051

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
YU817/74A YU39719B (en)	1973-04-02	1974-03-25	Process for obtaining new derivatives of vinbastine and leurocristine
YU1139/80A YU39876B (en)	1973-04-02	1980-04-25	Process for obtaining new vinblastine derivatives
YU1138/80A YU39875B (en)	1973-04-02	1980-04-25	Process for obtaining new derivatives of vinblastine leurocristine and leurosidine

Family Applications After (2)

Application Number	Title	Priority Date	Filing Date
YU1139/80A YU39876B (en)	1973-04-02	1980-04-25	Process for obtaining new vinblastine derivatives
YU1138/80A YU39875B (en)	1973-04-02	1980-04-25	Process for obtaining new derivatives of vinblastine leurocristine and leurosidine

Country Status (28)

Country	Link
JP (2)	JPS5919117B2 (en)
AR (2)	AR204004A1 (en)
AT (1)	AT340605B (en)
BE (1)	BE813168A (en)
BG (3)	BG21235A3 (en)
CA (1)	CA1042428A (en)
CH (1)	CH603669A5 (en)
CS (1)	CS185223B2 (en)
CY (1)	CY1044A (en)
DD (1)	DD113538A5 (en)
DE (1)	DE2415980A1 (en)
DK (1)	DK141511B (en)
ES (2)	ES424882A1 (en)
FR (1)	FR2223044B1 (en)
GB (1)	GB1463575A (en)
HK (1)	HK20180A (en)
HU (1)	HU171572B (en)
IE (1)	IE39071B1 (en)
IL (1)	IL44415A (en)
KE (1)	KE3028A (en)
MY (1)	MY8100025A (en)
NL (1)	NL181079C (en)
PH (1)	PH13623A (en)
RO (2)	RO77533A (en)
SE (1)	SE416206B (en)
SU (4)	SU731900A3 (en)
YU (3)	YU39719B (en)
ZA (1)	ZA741674B (en)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL48685A (en) *	1975-01-09	1980-03-31	Lilly Co Eli	Amides of vincadioline and vinblastine
GR69783B (en) *	1976-09-08	1982-07-07	Lilly Co Eli
USRE30561E (en)	1976-12-06	1981-03-31	Eli Lilly And Company	Vinca alkaloid intermediates
US4096148A (en) *	1976-12-06	1978-06-20	Eli Lilly And Company	Oxazolidinedione derivatives of Vinca alkaloids
USRE30560E (en) *	1976-12-06	1981-03-31	Eli Lilly And Company	Oxazolidinedione derivatives of Vinca alkaloids
US4203898A (en)	1977-08-29	1980-05-20	Eli Lilly And Company	Amide derivatives of VLB, leurosidine, leurocristine and related dimeric alkaloids
US4199504A (en) *	1978-05-15	1980-04-22	Eli Lilly And Company	Bridged cathranthus alkaloid dimers
US4357334A (en)	1980-03-20	1982-11-02	Eli Lilly And Company	Use of VLB 3-(2-chloroethyl) carboxamide in treating neoplasms
LU83822A1 (en) *	1981-12-08	1983-09-01	Omnichem Sa	N- (VINBLASTINOYL-23) DERIVATIVES OF AMINO ACIDS, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
OA06421A (en) *	1980-06-10	1981-09-30	Omnium Chimique Sa	Process for the preparation of N- (vinblastinoyl-23) derivatives of amino acids and peptides.
FR2623504B1 (en) *	1987-11-25	1990-03-09	Adir	NOVEL N- (VINBLASTINOYL-23) DERIVATIVES OF 1-AMINO METHYLPHOSPHONIC ACID, PROCESSES FOR THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
HUT76925A (en) *	1995-04-04	1998-01-28	MTA Enzimológiai Intézet	Bis-indole derivatives, process for the preparation thereof and pharmaceutical compositions containing them
US5948750A (en) *	1996-10-30	1999-09-07	Merck & Co., Inc.	Conjugates useful in the treatment of prostate cancer
US6326402B1 (en)	1998-08-12	2001-12-04	Octamer, Inc.	Methods for treating viral infections using a compound capable of inhibiting microtubules
EP1845974A1 (en)	2005-01-21	2007-10-24	Astex Therapeutics Limited	Pharmaceutical compounds
US7405227B2 (en)	2005-07-18	2008-07-29	Bipar Sciences, Inc.	Treatment of cancer
EP2061479A4 (en)	2006-09-05	2010-08-04	Bipar Sciences Inc	Inhibition of fatty acid synthesis by parp inhibitors and methods of treatment thereof
EP2059498A4 (en)	2006-09-05	2011-01-12	Bipar Sciences Inc	Treatment of cancer
US8916552B2 (en)	2006-10-12	2014-12-23	Astex Therapeutics Limited	Pharmaceutical combinations
JP5528807B2 (en)	2006-10-12	2014-06-25	アステックス、セラピューティックス、リミテッド	Compound drug
EP2217227B1 (en)	2007-11-12	2013-08-21	BiPar Sciences, Inc.	Treatment of breast cancer with 4-iodo-3-nitrobenzamide in combination with anti-tumor agents
JP6250710B2 (en) *	2013-04-19	2017-12-20	曁南大学	Preparation method of vinblastine derivative
CN113456797B (en) *	2021-06-18	2024-03-08	暨南大学	Application of vinblastine derivatives in preparation of medicines for treating osteosarcoma and/or soft tissue sarcoma

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3097137A (en) *	1960-05-19	1963-07-09	Canadian Patents Dev	Vincaleukoblastine

1974
- 1974-01-01 AR AR253105A patent/AR204004A1/en active
- 1974-03-13 IE IE532/74A patent/IE39071B1/en unknown
- 1974-03-13 IL IL44415A patent/IL44415A/en unknown
- 1974-03-13 ZA ZA00741674A patent/ZA741674B/en unknown
- 1974-03-22 CA CA195,760A patent/CA1042428A/en not_active Expired
- 1974-03-25 YU YU817/74A patent/YU39719B/en unknown
- 1974-03-25 CY CY1044A patent/CY1044A/en unknown
- 1974-03-25 GB GB1310174A patent/GB1463575A/en not_active Expired
- 1974-03-29 CH CH446374A patent/CH603669A5/xx not_active IP Right Cessation
- 1974-03-29 PH PH15676A patent/PH13623A/en unknown
- 1974-03-29 FR FR7411519A patent/FR2223044B1/fr not_active Expired
- 1974-04-01 SU SU742013753A patent/SU731900A3/en active
- 1974-04-01 HU HU74EI00000538A patent/HU171572B/en unknown
- 1974-04-01 DK DK178774AA patent/DK141511B/en not_active IP Right Cessation
- 1974-04-01 SE SE7404380A patent/SE416206B/en not_active IP Right Cessation
- 1974-04-01 CS CS7400002335A patent/CS185223B2/en unknown
- 1974-04-01 AT AT267974A patent/AT340605B/en not_active IP Right Cessation
- 1974-04-01 NL NLAANVRAGE7404423,A patent/NL181079C/en not_active IP Right Cessation
- 1974-04-02 BE BE1005847A patent/BE813168A/en not_active IP Right Cessation
- 1974-04-02 RO RO7498695A patent/RO77533A/en unknown
- 1974-04-02 ES ES424882A patent/ES424882A1/en not_active Expired
- 1974-04-02 BG BG028514A patent/BG21235A3/en unknown
- 1974-04-02 BG BG028513A patent/BG21612A3/en unknown
- 1974-04-02 RO RO78274A patent/RO73524B/en unknown
- 1974-04-02 DE DE2415980A patent/DE2415980A1/en active Granted
- 1974-04-02 DD DD177632A patent/DD113538A5/xx unknown
- 1974-04-02 JP JP49037765A patent/JPS5919117B2/en not_active Expired
- 1974-04-02 BG BG026279A patent/BG22831A3/en unknown
1975
- 1975-01-08 AR AR257228A patent/AR203882A1/en active
- 1975-07-04 SU SU752151512A patent/SU784783A3/en active
- 1975-07-09 SU SU752152020A patent/SU652896A3/en active
1976
- 1976-03-31 ES ES446571A patent/ES446571A1/en not_active Expired
- 1976-12-20 SU SU762429453A patent/SU623522A3/en active
1980
- 1980-02-27 KE KE3028A patent/KE3028A/en unknown
- 1980-04-17 HK HK201/80A patent/HK20180A/en unknown
- 1980-04-25 YU YU1139/80A patent/YU39876B/en unknown
- 1980-04-25 YU YU1138/80A patent/YU39875B/en unknown
1981
- 1981-12-30 MY MY25/81A patent/MY8100025A/en unknown
1983
- 1983-12-16 JP JP58238722A patent/JPS6033837B2/en not_active Expired

Also Published As

Publication number	Publication date
SU731900A3 (en)	1980-04-30
DE2415980C2 (en)	1989-11-09
IL44415A0 (en)	1974-06-30
IE39071L (en)	1974-10-02
CY1044A (en)	1980-08-01
DK141511B (en)	1980-04-08
NL181079B (en)	1987-01-16
RO73524A (en)	1984-10-31
YU39719B (en)	1985-04-30
JPS49128000A (en)	1974-12-07
BG21612A3 (en)	1976-07-20
SU652896A3 (en)	1979-03-15
YU39876B (en)	1985-04-30
AR203882A1 (en)	1975-10-31
AR204004A1 (en)	1975-11-12
HU171572B (en)	1978-02-28
NL181079C (en)	1987-06-16
DD113538A5 (en)	1975-06-12
BE813168A (en)	1974-10-02
JPS6033837B2 (en)	1985-08-05
PH13623A (en)	1980-08-07
NL7404423A (en)	1974-10-04
CS185223B2 (en)	1978-09-15
RO73524B (en)	1984-11-30
MY8100025A (en)	1981-12-31
JPS5919117B2 (en)	1984-05-02
ATA267974A (en)	1977-04-15
RO77533A (en)	1982-02-01
ES424882A1 (en)	1976-12-16
IL44415A (en)	1978-08-31
BG22831A3 (en)	1977-04-20
JPS59193895A (en)	1984-11-02
HK20180A (en)	1980-04-25
SE416206B (en)	1980-12-08
DK141511C (en)	1980-09-29
FR2223044B1 (en)	1978-06-30
SU623522A3 (en)	1978-09-05
GB1463575A (en)	1977-02-02
YU113880A (en)	1982-05-31
SU784783A3 (en)	1980-11-30
YU39875B (en)	1985-04-30
KE3028A (en)	1980-03-28
DE2415980A1 (en)	1974-10-10
ES446571A1 (en)	1977-06-16
FR2223044A1 (en)	1974-10-25
BG21235A3 (en)	1976-03-20
AU6671974A (en)	1975-09-18
ZA741674B (en)	1975-10-29
CH603669A5 (en)	1978-08-31
IE39071B1 (en)	1978-08-02
YU113980A (en)	1982-05-31
AT340605B (en)	1977-12-27
CA1042428A (en)	1978-11-14

Publication	Publication Date	Title
YU81774A (en)	1982-05-31	Process for preparing new derivatives of vinblastin and leurocrystin
CS187420B2 (en)	1979-01-31	Process for preparing new derivatives of pyrimidine
GR60708B (en)	1978-07-24	Preparation process of 2-acyl-4-oxo pyrazino-isoquinoline derivatives
CS189678B2 (en)	1979-04-30	Process for preparing derivatives of quinazoline
HU171684B (en)	1978-02-28	Process for preparing derivatives of 18-methyl-19-nor-20-oxo-pregnane
YU165775A (en)	1982-02-28	Process for preparing new derivatives of 3-amino-2-hydroxy-1-phenoxy-propane
CS187414B2 (en)	1979-01-31	Process for preparing antialergic derivatives of 3-nitrocumarine
YU338574A (en)	1982-05-31	Process for obtaining new derivatives of pregnane-21-acid
HU171804B (en)	1978-03-28	Process for preparing derivatives of 7-methoxy-6-thiatetracycline
CS182274B2 (en)	1978-04-28	Process for preparing derivatives of 7-amino-delta-up3-cepheme
CS187436B2 (en)	1979-01-31	Process for preparing derivatives of triazoloisoquinoline
CS194206B2 (en)	1979-11-30	Process for preparing complex of antibiotic av290-alkylsulphonate and izolation thereof
HU171726B (en)	1978-03-28	Process for preparing derivatives of the 1-phenoxy-3-amino-propan-2-ol
CS188973B2 (en)	1979-03-30	Process for preparing new derivatives of ampiciline,amoxiciline and epiciline
HU173425B (en)	1979-05-28	Process for preparing 1-oxide of 7beta-phenoxy-acetamido-3-methyl-3-cephem-4-carboxylic acid -methoxymethyl-ester
HU173517B (en)	1979-06-28	Process for preparing copolycondensation products of beta-haloalkylphosphates and dialkyl-phosphonates
CS189660B2 (en)	1979-04-30	Process for preparing derivatives of dibenzoxepine
CS183768B2 (en)	1978-07-31	Process for preparing new derivatives of thiazolylurea
YU214174A (en)	1982-06-18	Process for obtaining new derivatives of amino-pyrrol
CS180600B2 (en)	1978-01-31	Process for preparing new derivatives of 2-formyl-3-carboxamidochinoxalin-di-n-oxides
EG14680A (en)	1984-09-30	Process for preparing of pyrazinoisoquinoline derivatives
ZA744154B (en)	1975-07-30	Novel imidazole derivatives and process for their preparation
CS188960B2 (en)	1979-03-30	Process for preparing new derivatives of 2-phenylindole
CS188961B2 (en)	1979-03-30	Process for preparing new derivatives of benzhydryloxy-alkylamine
KE2929A (en)	1979-03-30	Process for 11a-dehalogenation of 11a-halotetracyclines