IL34433A - Synthesis of substituted 2,4-diamino-5-benzylpyrimidine and sulphone intermediates therefor - Google Patents

Synthesis of substituted 2,4-diamino-5-benzylpyrimidine and sulphone intermediates therefor

Info

Publication number: IL34433A
Authority: IL; Israel
Prior art keywords: benzylpyrimidine; sulphone; diamino; synthesis; substituted
Prior art date: 1969-05-16

Application number

IL34433A

Other languages

English (en)

Other versions

IL34433A0 (en

Original Assignee

Wellcome Found

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1969-05-16

Filing date

1970-05-01

Publication date

1971-10-20

1970-05-01 Application filed by Wellcome Found filed Critical Wellcome Found

1970-07-19 Publication of IL34433A0 publication Critical patent/IL34433A0/xx

1971-10-20 Publication of IL34433A publication Critical patent/IL34433A/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
- C07D239/49—Two nitrogen atoms with an aralkyl radical, or substituted aralkyl radical, attached in position 5, e.g. trimethoprim
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
- C07D317/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

IL34433A 1969-05-16 1970-05-01 Synthesis of substituted 2,4-diamino-5-benzylpyrimidine and sulphone intermediates therefor IL34433A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB2517169		1969-05-16

Publications (2)

Publication Number	Publication Date
IL34433A0 IL34433A0 (en)	1970-07-19
IL34433A true IL34433A (en)	1971-10-20

Family

ID=10223379

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL34433A IL34433A (en)	1969-05-16	1970-05-01	Synthesis of substituted 2,4-diamino-5-benzylpyrimidine and sulphone intermediates therefor

Country Status (14)

Country	Link
JP (1)	JPS505184B1 (xx)
AT (1)	AT308082B (xx)
BR (1)	BR6915082D0 (xx)
CA (1)	CA994812A (xx)
CH (1)	CH544071A (xx)
DE (1)	DE2023977C2 (xx)
ES (3)	ES379700A1 (xx)
FI (1)	FI56375C (xx)
FR (1)	FR2070070A1 (xx)
IL (1)	IL34433A (xx)
IT (1)	IT1021507B (xx)
NL (2)	NL173395C (xx)
PL (1)	PL92440B1 (xx)
SE (2)	SE400777B (xx)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1469521A (en) *	1973-01-05	1977-04-06	Wellcome Found	Antimicrobial preparations
US4687861A (en) *	1984-11-28	1987-08-18	Ciba-Geigy Corporation	Microbicidal compositions
PT1725540E (pt) *	2004-03-05	2012-11-29	Hoffmann La Roche	Diaminopirimidinas como antagonistas de p2x3 e p2x2/3

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3049544A (en) *		1962-08-14		Method for the preparation of
DE1103931B (de)	1957-02-21	1961-04-06	Wellcome Found	Verfahren zur Herstellung von 2, 4-Diamino-5-benzylpyrimidinderivaten
DE1303727B (de)	1959-09-03	1976-02-05	Ausscheidung aus: 14 45 176 The Wellcome Foundation Ltd., London	Alpha-Arylidensubstituierte Propioni-Irile
NL122146C (xx) *	1960-09-02
DE1620729A1 (de)	1965-07-08	1970-08-20	Wellcome Found	Verfahren zur Herstellung von substituierten Benzylpyrimidinen
GB1261455A (en)	1969-03-06	1972-01-26	Burroughs Wellcome Co	Improvements in or relating to substituted acrylonitriles

1969
- 1969-12-12 BR BR215082/69A patent/BR6915082D0/pt unknown
1970
- 1970-03-05 PL PL1970177150A patent/PL92440B1/pl unknown
- 1970-03-06 AT AT100472A patent/AT308082B/de active
- 1970-05-01 IL IL34433A patent/IL34433A/xx unknown
- 1970-05-13 FI FI1338/70A patent/FI56375C/fi active
- 1970-05-14 ES ES379700A patent/ES379700A1/es not_active Expired
- 1970-05-15 DE DE2023977A patent/DE2023977C2/de not_active Expired
- 1970-05-15 FR FR7017799A patent/FR2070070A1/fr active Granted
- 1970-05-15 IT IT50715/70A patent/IT1021507B/it active
- 1970-05-15 NL NLAANVRAGE7007108,A patent/NL173395C/xx not_active IP Right Cessation
- 1970-05-15 JP JP45041540A patent/JPS505184B1/ja active Pending
- 1970-05-15 SE SE7006713A patent/SE400777B/xx unknown
- 1970-05-15 CH CH732370A patent/CH544071A/de not_active IP Right Cessation
- 1970-05-19 CA CA083,401A patent/CA994812A/en not_active Expired
1972
- 1972-09-15 ES ES406726A patent/ES406726A1/es not_active Expired
- 1972-09-15 ES ES406725A patent/ES406725A1/es not_active Expired
1973
- 1973-06-07 SE SE7308030A patent/SE398878B/xx unknown
1980
- 1980-08-25 NL NL8004796A patent/NL8004796A/nl not_active Application Discontinuation

Also Published As

Publication number	Publication date
IT1021507B (it)	1978-02-20
IL34433A0 (en)	1970-07-19
NL8004796A (nl)	1980-11-28
DE2023977C2 (de)	1984-03-15
NL7007108A (xx)	1970-11-18
ES406725A1 (es)	1975-10-01
FR2070070B1 (xx)	1974-10-11
BR6915082D0 (pt)	1973-03-08
JPS505184B1 (xx)	1975-02-28
ES406726A1 (es)	1975-10-01
ES379700A1 (es)	1973-01-16
SE398878B (sv)	1978-01-23
NL173395B (nl)	1983-08-16
FI56375C (fi)	1980-01-10
AT308082B (de)	1973-06-25
PL92440B1 (en)	1977-04-30
CA994812A (en)	1976-08-10
FR2070070A1 (en)	1971-09-10
SE400777B (sv)	1978-04-10
NL173395C (nl)	1984-01-16
DE2023977A1 (de)	1971-02-18
CH544071A (de)	1973-11-15
FI56375B (fi)	1979-09-28

Publication	Publication Date	Title
CA957684A (en)	1974-11-12	Synthesis of 1h-pyrazolo(3,2,-c)-s-triazoles
AR199463A1 (es)	1974-09-09	Sintesis de nucleosidos de 1,2,4-triazol-3-sustituidos
IL33940A0 (en)	1970-04-20	Preparation of pyrazinamides and novel intermediates
CA935622A (en)	1973-10-23	Synthesis of ammonia
IL34400A (en)	1974-05-16	5'-esters of ara-cytidine
JPS5762294A (en)	1982-04-15	Manufacture of 5'-o-acyl-ara-cytidines
GB1401944A (en)	1975-08-06	Sulphone intermediates
IL35894A (en)	1974-03-14	The preparation of 1,2,4-triazine-5-ones and certain novel intermediates being 5-imino-1,2,4-triazine derivatives
IL34433A (en)	1971-10-20	Synthesis of substituted 2,4-diamino-5-benzylpyrimidine and sulphone intermediates therefor
CA919701A (en)	1973-01-23	Synthesis of 2,4,6-tri-t-butyl-4-methoxycyclohexa-2,5-dien-1-one
IL38145A0 (en)	1972-01-27	Substituted semicarbazones of 2',6'-dihalobenzaldehydes and their preparation
AU6382073A (en)	1975-06-26	Synthesis of %&<-glaziovine
IL39221A (en)	1975-11-25	The preparation of 2,4-diamino-5-benzyl-pyrimidines and novel 2,4-diamino-6-alkylthio-5-benzyl-pyrimidine intermediates
BE749038A (fr)	1970-10-16	Synthese d'alcadienols
BE759354A (fr)	1971-04-30	Preparation de dihydroxy-1,4-dioxannes
BE763249A (fr)	1971-07-16	Piece d'horlogerie
CA963905A (en)	1975-03-04	Intermediates in the synthesis of 6,7,8-trialkoxy-4-aminoquinazolines
IL39957A (en)	1975-02-10	The preparation of l-tyrosine derivatives and some novel intermediates therefor
ZA706818B (en)	1971-07-28	Benzopyran-5-ols and coumarin intermediates therefor
CA922312A (en)	1973-03-06	Synthesis of tetracyclines
ZA711371B (en)	1972-10-25	Production of 1,1'-peroxydicyclohexylamine
IL34384A0 (en)	1970-06-17	Derivatives of 2,6-diaminobenzothiazole
IL34503A (en)	1974-06-30	The manufacture of tyrosine derivatives
CA822101A (en)	1969-09-02	Synthesis of 1-19-nor-steroids
CA642201A (en)	1962-06-05	Synthesis of 1,1-diarylethane