IL34433A0 - Synthesis of substituted 2,4-diamino-5-benzylpyrimidine - Google Patents

Synthesis of substituted 2,4-diamino-5-benzylpyrimidine

Info

Publication number: IL34433A0
Authority: IL; Israel
Prior art keywords: benzylpyrimidine; diamino; synthesis; substituted
Prior art date: 1969-05-16

Application number

IL34433A

Other versions

IL34433A (en

Original Assignee

Wellcome Found

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1969-05-16

Filing date

1970-05-01

Publication date

1970-07-19

1970-05-01 Application filed by Wellcome Found filed Critical Wellcome Found

1970-07-19 Publication of IL34433A0 publication Critical patent/IL34433A0/en

1971-10-20 Publication of IL34433A publication Critical patent/IL34433A/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
- C07D239/49—Two nitrogen atoms with an aralkyl radical, or substituted aralkyl radical, attached in position 5, e.g. trimethoprim
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
- C07D317/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

IL34433A 1969-05-16 1970-05-01 Synthesis of substituted 2,4-diamino-5-benzylpyrimidine and sulphone intermediates therefor IL34433A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB2517169		1969-05-16

Publications (2)

Publication Number	Publication Date
IL34433A0 true IL34433A0 (en)	1970-07-19
IL34433A IL34433A (en)	1971-10-20

Family

ID=10223379

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL34433A IL34433A (en)	1969-05-16	1970-05-01	Synthesis of substituted 2,4-diamino-5-benzylpyrimidine and sulphone intermediates therefor

Country Status (14)

Country	Link
JP (1)	JPS505184B1 (en)
AT (1)	AT308082B (en)
BR (1)	BR6915082D0 (en)
CA (1)	CA994812A (en)
CH (1)	CH544071A (en)
DE (1)	DE2023977C2 (en)
ES (3)	ES379700A1 (en)
FI (1)	FI56375C (en)
FR (1)	FR2070070A1 (en)
IL (1)	IL34433A (en)
IT (1)	IT1021507B (en)
NL (2)	NL173395C (en)
PL (1)	PL92440B1 (en)
SE (2)	SE400777B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1469521A (en) *	1973-01-05	1977-04-06	Wellcome Found	Antimicrobial preparations
US4687861A (en) *	1984-11-28	1987-08-18	Ciba-Geigy Corporation	Microbicidal compositions
PT1725540E (en) *	2004-03-05	2012-11-29	Hoffmann La Roche	Diaminopyrimidines as p2x3 and p2x2/3 antagonists

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3049544A (en) *		1962-08-14		Method for the preparation of
DE1103931B (en)	1957-02-21	1961-04-06	Wellcome Found	Process for the preparation of 2,4-diamino-5-benzylpyrimidine derivatives
DE1303727B (en)	1959-09-03	1976-02-05	Ausscheidung aus: 14 45 176 The Wellcome Foundation Ltd., London	Alpha-arylidene-substituted propioni-iriles
NL122146C (en) *	1960-09-02
DE1620729A1 (en)	1965-07-08	1970-08-20	Wellcome Found	Process for the preparation of substituted benzylpyrimidines
GB1261455A (en)	1969-03-06	1972-01-26	Burroughs Wellcome Co	Improvements in or relating to substituted acrylonitriles

1969
- 1969-12-12 BR BR215082/69A patent/BR6915082D0/en unknown
1970
- 1970-03-05 PL PL1970177150A patent/PL92440B1/en unknown
- 1970-03-06 AT AT100472A patent/AT308082B/en active
- 1970-05-01 IL IL34433A patent/IL34433A/en unknown
- 1970-05-13 FI FI1338/70A patent/FI56375C/en active
- 1970-05-14 ES ES379700A patent/ES379700A1/en not_active Expired
- 1970-05-15 JP JP45041540A patent/JPS505184B1/ja active Pending
- 1970-05-15 IT IT50715/70A patent/IT1021507B/en active
- 1970-05-15 CH CH732370A patent/CH544071A/en not_active IP Right Cessation
- 1970-05-15 FR FR7017799A patent/FR2070070A1/en active Granted
- 1970-05-15 DE DE2023977A patent/DE2023977C2/en not_active Expired
- 1970-05-15 SE SE7006713A patent/SE400777B/en unknown
- 1970-05-15 NL NLAANVRAGE7007108,A patent/NL173395C/en not_active IP Right Cessation
- 1970-05-19 CA CA083,401A patent/CA994812A/en not_active Expired
1972
- 1972-09-15 ES ES406725A patent/ES406725A1/en not_active Expired
- 1972-09-15 ES ES406726A patent/ES406726A1/en not_active Expired
1973
- 1973-06-07 SE SE7308030A patent/SE398878B/en unknown
1980
- 1980-08-25 NL NL8004796A patent/NL8004796A/en not_active Application Discontinuation

Also Published As

Publication number	Publication date
DE2023977C2 (en)	1984-03-15
DE2023977A1 (en)	1971-02-18
ES406725A1 (en)	1975-10-01
SE398878B (en)	1978-01-23
FI56375C (en)	1980-01-10
NL173395C (en)	1984-01-16
FI56375B (en)	1979-09-28
SE400777B (en)	1978-04-10
PL92440B1 (en)	1977-04-30
NL7007108A (en)	1970-11-18
ES406726A1 (en)	1975-10-01
CH544071A (en)	1973-11-15
BR6915082D0 (en)	1973-03-08
NL173395B (en)	1983-08-16
JPS505184B1 (en)	1975-02-28
ES379700A1 (en)	1973-01-16
IL34433A (en)	1971-10-20
AT308082B (en)	1973-06-25
CA994812A (en)	1976-08-10
IT1021507B (en)	1978-02-20
FR2070070B1 (en)	1974-10-11
FR2070070A1 (en)	1971-09-10
NL8004796A (en)	1980-11-28

Publication	Publication Date	Title
ZA707841B (en)	1971-09-29	Improvements relating to substituted n-allyl-2-arylamino-imidazolines-(2)
ZA706167B (en)	1971-05-27	Improvements relating to 1,1,1-trichlo-roethane derivatives
CA935622A (en)	1973-10-23	Synthesis of ammonia
ZA707840B (en)	1971-09-29	Improvements relating to substituted n-cycloalkyl-arylamino-imidazolines-(2)
CA919701A (en)	1973-01-23	Synthesis of 2,4,6-tri-t-butyl-4-methoxycyclohexa-2,5-dien-1-one
IL34433A0 (en)	1970-07-19	Synthesis of substituted 2,4-diamino-5-benzylpyrimidine
ZA708301B (en)	1972-07-26	Derivatives of 2,9-dioxatricyclo-(4,3,1,0,3,7)-decane
ZA704574B (en)	1971-03-31	New 21,21-dichloro-steroids
ZA705839B (en)	1971-04-28	Novel 4-amino-2-methyl-pyrimidines
ZA704974B (en)	1971-04-28	14 beta-hydroxy-15a-acyloxy-ca9denolides
HK23078A (en)	1978-05-12	4,4-diaryl-piperidines
IL34384A0 (en)	1970-06-17	Derivatives of 2,6-diaminobenzothiazole
IL44105A0 (en)	1974-05-16	Novel 17alpha-propadienyl-17beta-hydroxy-estra-4,9(10)11-trien-3-ones
IL35520A0 (en)	1970-12-24	Manufacture of 1,1'-disubstituted-4,4'-bipyridylium salts
ZA71927B (en)	1971-10-27	Derivatives of 1,2-diphenyl-ethane
ZA711371B (en)	1972-10-25	Production of 1,1'-peroxydicyclohexylamine
ZA704119B (en)	1971-03-31	Diamond synthesis
IL35472A0 (en)	1970-12-24	Manufacture of 1,1'-disubstituted-4,4-bipyridylium salts
CA822101A (en)	1969-09-02	Synthesis of 1-19-nor-steroids
ZA704005B (en)	1971-03-31	Synthesis of tetracyclines
IL32155A0 (en)	1969-07-30	Synthesis of epoxyphosphonates
IL34503A (en)	1974-06-30	The manufacture of tyrosine derivatives
ZA70940B (en)	1971-10-27	Substituted bis-benzimidazoles
AU2118470A (en)	1972-04-20	Preparation of beta-halogenopropionitriles.
CA963905A (en)	1975-03-04	Intermediates in the synthesis of 6,7,8-trialkoxy-4-aminoquinazolines