IL132126A0 - Aqueous immunologic adjuvant compositions of monophosphoryl lipid a - Google Patents
Aqueous immunologic adjuvant compositions of monophosphoryl lipid aInfo
- Publication number
- IL132126A0 IL132126A0 IL13212698A IL13212698A IL132126A0 IL 132126 A0 IL132126 A0 IL 132126A0 IL 13212698 A IL13212698 A IL 13212698A IL 13212698 A IL13212698 A IL 13212698A IL 132126 A0 IL132126 A0 IL 132126A0
- Authority
- IL
- Israel
- Prior art keywords
- surfactant
- lipid
- derivative
- attenuated
- monophosphoryl lipid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
- C07H13/06—Fatty acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Virology (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Pulmonology (AREA)
- Biochemistry (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US83107397A | 1997-04-01 | 1997-04-01 | |
PCT/US1998/006528 WO1998043670A2 (en) | 1997-04-01 | 1998-04-01 | Aqueous immunologic adjuvant compositions of monophosphoryl lipid a |
Publications (1)
Publication Number | Publication Date |
---|---|
IL132126A0 true IL132126A0 (en) | 2001-03-19 |
Family
ID=25258229
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL13212698A IL132126A0 (en) | 1997-04-01 | 1998-04-01 | Aqueous immunologic adjuvant compositions of monophosphoryl lipid a |
IL132126A IL132126A (en) | 1997-04-01 | 1999-09-29 | Aqueous compositions of monophosphoryl lipid A as an immunological supplement |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL132126A IL132126A (en) | 1997-04-01 | 1999-09-29 | Aqueous compositions of monophosphoryl lipid A as an immunological supplement |
Country Status (19)
Country | Link |
---|---|
EP (1) | EP0971739B1 (tr) |
JP (1) | JP5019494B2 (tr) |
KR (1) | KR100603884B1 (tr) |
CN (2) | CN1259052A (tr) |
AT (1) | ATE278419T1 (tr) |
AU (1) | AU743114B2 (tr) |
BR (1) | BR9811262A (tr) |
CA (1) | CA2284586C (tr) |
DE (1) | DE69826842T2 (tr) |
ES (1) | ES2227825T3 (tr) |
HK (1) | HK1026613A1 (tr) |
HU (1) | HUP0001403A3 (tr) |
IL (2) | IL132126A0 (tr) |
NO (1) | NO994760L (tr) |
NZ (1) | NZ338101A (tr) |
PL (1) | PL190237B1 (tr) |
PT (1) | PT971739E (tr) |
TR (1) | TR199902437T2 (tr) |
WO (1) | WO1998043670A2 (tr) |
Families Citing this family (71)
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---|---|---|---|---|
US6491919B2 (en) * | 1997-04-01 | 2002-12-10 | Corixa Corporation | Aqueous immunologic adjuvant compostions of monophosphoryl lipid A |
GB9706957D0 (en) | 1997-04-05 | 1997-05-21 | Smithkline Beecham Plc | Formulation |
GB9820525D0 (en) | 1998-09-21 | 1998-11-11 | Allergy Therapeutics Ltd | Formulation |
GB0000891D0 (en) * | 2000-01-14 | 2000-03-08 | Allergy Therapeutics Ltd | Formulation |
PT1326638E (pt) | 2000-10-18 | 2008-02-06 | Glaxosmithkline Biolog Sa | Vacinas contra cancros |
CA2438942A1 (en) | 2001-02-23 | 2002-09-26 | Glaxosmithkline Biologicals S.A. | Influenza vaccine formulations for intradermal delivery |
US20030031684A1 (en) | 2001-03-30 | 2003-02-13 | Corixa Corporation | Methods for the production of 3-O-deactivated-4'-monophosphoryl lipid a (3D-MLA) |
GB0109297D0 (en) | 2001-04-12 | 2001-05-30 | Glaxosmithkline Biolog Sa | Vaccine |
MY134424A (en) | 2001-05-30 | 2007-12-31 | Saechsisches Serumwerk | Stable influenza virus preparations with low or no amount of thiomersal |
US20100221284A1 (en) | 2001-05-30 | 2010-09-02 | Saech-Sisches Serumwerk Dresden | Novel vaccine composition |
GB0321615D0 (en) | 2003-09-15 | 2003-10-15 | Glaxo Group Ltd | Improvements in vaccination |
CA2590906C (en) * | 2004-12-17 | 2017-01-03 | Nvi Nederlands Vaccininstituut | Deacylation of lps in gram negative bacteria |
GB0503337D0 (en) | 2005-02-17 | 2005-03-23 | Glaxosmithkline Biolog Sa | Compositions |
GB0504436D0 (en) | 2005-03-03 | 2005-04-06 | Glaxosmithkline Biolog Sa | Vaccine |
PL2457926T3 (pl) | 2005-04-29 | 2015-03-31 | Glaxosmithkline Biologicals Sa | Nowy sposób profilaktyki lub leczenia zakażenia m. tuberculosis |
BRPI0614254A2 (pt) * | 2005-08-02 | 2011-03-15 | Novartis Vaccines & Diagnostic | redução de interferência entre adjuvantes contendo óleo e antìgenos contendo tensoativos |
TWI457133B (zh) * | 2005-12-13 | 2014-10-21 | Glaxosmithkline Biolog Sa | 新穎組合物 |
US8018440B2 (en) | 2005-12-30 | 2011-09-13 | Microsoft Corporation | Unintentional touch rejection |
ES2822058T3 (es) | 2006-09-26 | 2021-04-28 | Infectious Disease Res Inst | Composición de vacuna que contiene un adyuvante sintético |
US20090181078A1 (en) | 2006-09-26 | 2009-07-16 | Infectious Disease Research Institute | Vaccine composition containing synthetic adjuvant |
US8836648B2 (en) | 2009-05-27 | 2014-09-16 | Microsoft Corporation | Touch pull-in gesture |
PT2437753T (pt) | 2009-06-05 | 2016-11-23 | Infectious Disease Res Inst | Adjuvantes lipídicos de glucopiranosilo sintéticos e composições de vacina contendo os mesmos |
FR2954703B1 (fr) | 2009-12-28 | 2013-12-13 | Chu Nantes | Agonistes des recepteurs tlr 4 et 9 pour prevenir les complications septiques de l'immunodepression post-traumatique chez les patients hospitalises pour traumatismes severes |
US8261213B2 (en) | 2010-01-28 | 2012-09-04 | Microsoft Corporation | Brush, carbon-copy, and fill gestures |
US9411504B2 (en) | 2010-01-28 | 2016-08-09 | Microsoft Technology Licensing, Llc | Copy and staple gestures |
US9519356B2 (en) | 2010-02-04 | 2016-12-13 | Microsoft Technology Licensing, Llc | Link gestures |
US9367205B2 (en) | 2010-02-19 | 2016-06-14 | Microsoft Technolgoy Licensing, Llc | Radial menus with bezel gestures |
US9310994B2 (en) | 2010-02-19 | 2016-04-12 | Microsoft Technology Licensing, Llc | Use of bezel as an input mechanism |
US8799827B2 (en) | 2010-02-19 | 2014-08-05 | Microsoft Corporation | Page manipulations using on and off-screen gestures |
US9454304B2 (en) | 2010-02-25 | 2016-09-27 | Microsoft Technology Licensing, Llc | Multi-screen dual tap gesture |
US8751970B2 (en) | 2010-02-25 | 2014-06-10 | Microsoft Corporation | Multi-screen synchronous slide gesture |
US8707174B2 (en) | 2010-02-25 | 2014-04-22 | Microsoft Corporation | Multi-screen hold and page-flip gesture |
US9075522B2 (en) | 2010-02-25 | 2015-07-07 | Microsoft Technology Licensing, Llc | Multi-screen bookmark hold gesture |
US8612874B2 (en) | 2010-12-23 | 2013-12-17 | Microsoft Corporation | Presenting an application change through a tile |
US8689123B2 (en) | 2010-12-23 | 2014-04-01 | Microsoft Corporation | Application reporting in an application-selectable user interface |
US9423951B2 (en) | 2010-12-31 | 2016-08-23 | Microsoft Technology Licensing, Llc | Content-based snap point |
US9383917B2 (en) | 2011-03-28 | 2016-07-05 | Microsoft Technology Licensing, Llc | Predictive tiling |
GB201106357D0 (en) | 2011-04-14 | 2011-06-01 | Pessi Antonello | Composition and uses thereof |
CA2832307A1 (en) | 2011-04-08 | 2012-10-18 | Immune Design Corp. | Immunogenic compositions and methods of using the compositions for inducing humoral and cellular immune responses |
US9104440B2 (en) | 2011-05-27 | 2015-08-11 | Microsoft Technology Licensing, Llc | Multi-application environment |
US9658766B2 (en) | 2011-05-27 | 2017-05-23 | Microsoft Technology Licensing, Llc | Edge gesture |
US9158445B2 (en) | 2011-05-27 | 2015-10-13 | Microsoft Technology Licensing, Llc | Managing an immersive interface in a multi-application immersive environment |
US9104307B2 (en) | 2011-05-27 | 2015-08-11 | Microsoft Technology Licensing, Llc | Multi-application environment |
US9557909B2 (en) | 2011-09-09 | 2017-01-31 | Microsoft Technology Licensing, Llc | Semantic zoom linguistic helpers |
US9244802B2 (en) | 2011-09-10 | 2016-01-26 | Microsoft Technology Licensing, Llc | Resource user interface |
US9146670B2 (en) | 2011-09-10 | 2015-09-29 | Microsoft Technology Licensing, Llc | Progressively indicating new content in an application-selectable user interface |
US20150190501A1 (en) | 2011-09-12 | 2015-07-09 | Imperial Innovations Limited | Methods and compositions for raising an immune response to hiv |
DK2850431T3 (en) | 2012-05-16 | 2018-07-16 | Immune Design Corp | Vaccines against HSV-2 |
EP2666785A1 (en) | 2012-05-23 | 2013-11-27 | Affiris AG | Complement component C5a-based vaccine |
EP2703483A1 (en) | 2012-08-29 | 2014-03-05 | Affiris AG | PCSK9 peptide vaccine |
US10232035B2 (en) | 2012-09-14 | 2019-03-19 | The Regents Of The University Of Colorado, A Body Corporate | Conditionally replication deficient herpes virus and use thereof in vaccines |
US9582122B2 (en) | 2012-11-12 | 2017-02-28 | Microsoft Technology Licensing, Llc | Touch-sensitive bezel techniques |
CN105209047B (zh) | 2013-04-18 | 2020-08-18 | 免疫设计股份有限公司 | 用于癌症治疗的gla单一疗法 |
US9463198B2 (en) | 2013-06-04 | 2016-10-11 | Infectious Disease Research Institute | Compositions and methods for reducing or preventing metastasis |
US9477337B2 (en) | 2014-03-14 | 2016-10-25 | Microsoft Technology Licensing, Llc | Conductive trace routing for display and bezel sensors |
JP6894237B2 (ja) * | 2014-03-26 | 2021-06-30 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | 変異体ブドウ球菌抗原 |
JP6820830B2 (ja) | 2014-07-18 | 2021-01-27 | ユニヴァーシティ オブ ワシントン | がんワクチン組成物およびその使用方法 |
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GB201614799D0 (en) | 2016-09-01 | 2016-10-19 | Glaxosmithkline Biologicals Sa | Compositions |
EP3295956A1 (en) | 2016-09-20 | 2018-03-21 | Biomay Ag | Polypeptide construct comprising fragments of allergens |
EP3678695A1 (en) | 2017-09-08 | 2020-07-15 | Infectious Disease Research Institute | Liposomal formulations comprising saponin and methods of use |
TW202003023A (zh) | 2018-03-12 | 2020-01-16 | 美商詹森藥物公司 | 針對尿路感染之疫苗 |
EP3569612A1 (en) | 2018-05-18 | 2019-11-20 | Biomay Ag | Treatment and prevention of house dust mite allergies |
EA202192390A1 (ru) | 2019-03-18 | 2021-12-03 | Янссен Фармасьютикалз, Инк. | Биоконъюгаты полисахаридных о-антигенов e.coli, способы их получения и способы их применения |
HUE063875T2 (hu) | 2019-03-18 | 2024-02-28 | Janssen Pharmaceuticals Inc | Eljárások E. coli O-antigén poliszacharidok biokonjugátumainak elõállítására, ezek készítményei és felhasználásuk módszerei |
IL291821A (en) | 2019-10-02 | 2022-06-01 | Janssen Vaccines & Prevention Bv | Staphylococcus peptides and methods of use |
BR112022013720A2 (pt) | 2020-01-16 | 2022-10-11 | Janssen Pharmaceuticals Inc | Mutante fimh, composições com o mesmo e seu uso |
UY39428A (es) | 2020-09-17 | 2022-03-31 | Janssen Pharmaceuticals Inc | Composiciones de vacunas multivalentes y usos de las mismas |
AU2022207740B2 (en) | 2021-01-12 | 2024-06-06 | Janssen Pharmaceuticals, Inc. | Fimh mutants, compositions therewith and use thereof |
UY39710A (es) | 2021-04-01 | 2022-09-30 | Janssen Pharmaceuticals Inc | Producción de bioconjugados de o18 de e. coli |
US20240180940A1 (en) * | 2021-05-27 | 2024-06-06 | Revelation Biosciences, Inc. | Mpla compositions and methods of use |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4912094B1 (en) * | 1988-06-29 | 1994-02-15 | Ribi Immunochem Research Inc. | Modified lipopolysaccharides and process of preparation |
US5068191A (en) * | 1989-08-31 | 1991-11-26 | The Biomembrane Institute | Purified histo-blood group a glycosyltransferase and antibodies thereto |
US5552141A (en) * | 1991-10-30 | 1996-09-03 | Ribi; Hans O. | Polymeric immunological adjuvants |
AU685443B2 (en) * | 1993-03-23 | 1998-01-22 | Smithkline Beecham Biologicals (Sa) | Vaccine compositions containing 3-O deacylated monophosphoryl lipid A |
-
1998
- 1998-04-01 ES ES98915239T patent/ES2227825T3/es not_active Expired - Lifetime
- 1998-04-01 TR TR1999/02437T patent/TR199902437T2/tr unknown
- 1998-04-01 BR BR9811262-7A patent/BR9811262A/pt not_active Application Discontinuation
- 1998-04-01 CA CA2284586A patent/CA2284586C/en not_active Expired - Lifetime
- 1998-04-01 DE DE69826842T patent/DE69826842T2/de not_active Expired - Lifetime
- 1998-04-01 AU AU69473/98A patent/AU743114B2/en not_active Ceased
- 1998-04-01 IL IL13212698A patent/IL132126A0/xx active IP Right Grant
- 1998-04-01 EP EP98915239A patent/EP0971739B1/en not_active Expired - Lifetime
- 1998-04-01 HU HU0001403A patent/HUP0001403A3/hu unknown
- 1998-04-01 WO PCT/US1998/006528 patent/WO1998043670A2/en active IP Right Grant
- 1998-04-01 PT PT98915239T patent/PT971739E/pt unknown
- 1998-04-01 JP JP54200198A patent/JP5019494B2/ja not_active Expired - Lifetime
- 1998-04-01 NZ NZ338101A patent/NZ338101A/en unknown
- 1998-04-01 KR KR1019997008958A patent/KR100603884B1/ko not_active IP Right Cessation
- 1998-04-01 AT AT98915239T patent/ATE278419T1/de active
- 1998-04-01 CN CN98804685A patent/CN1259052A/zh active Pending
- 1998-04-01 PL PL98336698A patent/PL190237B1/pl not_active IP Right Cessation
- 1998-04-01 CN CNB2004100713486A patent/CN1326564C/zh not_active Expired - Fee Related
-
1999
- 1999-09-29 IL IL132126A patent/IL132126A/en not_active IP Right Cessation
- 1999-09-30 NO NO994760A patent/NO994760L/no not_active Application Discontinuation
-
2000
- 2000-07-19 HK HK00104464A patent/HK1026613A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EP0971739B1 (en) | 2004-10-06 |
AU743114B2 (en) | 2002-01-17 |
KR100603884B1 (ko) | 2006-07-24 |
PL190237B1 (pl) | 2005-11-30 |
JP2001526640A (ja) | 2001-12-18 |
HUP0001403A3 (en) | 2003-05-28 |
ATE278419T1 (de) | 2004-10-15 |
CA2284586C (en) | 2011-02-08 |
DE69826842D1 (de) | 2004-11-11 |
IL132126A (en) | 2006-10-05 |
AU6947398A (en) | 1998-10-22 |
CN1259052A (zh) | 2000-07-05 |
HK1026613A1 (en) | 2000-12-22 |
TR199902437T2 (tr) | 2000-01-21 |
KR20010005882A (ko) | 2001-01-15 |
NO994760L (no) | 1999-11-26 |
CN1575815A (zh) | 2005-02-09 |
NO994760D0 (no) | 1999-09-30 |
EP0971739A2 (en) | 2000-01-19 |
HUP0001403A2 (hu) | 2000-09-28 |
CN1326564C (zh) | 2007-07-18 |
BR9811262A (pt) | 2000-10-17 |
JP5019494B2 (ja) | 2012-09-05 |
WO1998043670A3 (en) | 1998-12-30 |
ES2227825T3 (es) | 2005-04-01 |
NZ338101A (en) | 2002-03-28 |
WO1998043670A2 (en) | 1998-10-08 |
PT971739E (pt) | 2004-12-31 |
PL336698A1 (en) | 2000-07-03 |
DE69826842T2 (de) | 2005-11-24 |
CA2284586A1 (en) | 1998-10-08 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FF | Patent granted | ||
KB | Patent renewed | ||
KB | Patent renewed |