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HUP0001403A2 - Monofoszforil-lipid-A-t tartalmazó vizes immunológiai adjuváns összetételek - Google Patents

Monofoszforil-lipid-A-t tartalmazó vizes immunológiai adjuváns összetételek

Info

Publication number
HUP0001403A2
HUP0001403A2 HU0001403A HUP0001403A HUP0001403A2 HU P0001403 A2 HUP0001403 A2 HU P0001403A2 HU 0001403 A HU0001403 A HU 0001403A HU P0001403 A HUP0001403 A HU P0001403A HU P0001403 A2 HUP0001403 A2 HU P0001403A2
Authority
HU
Hungary
Prior art keywords
surfactant
lipid
derivative
antigen
weakened
Prior art date
Application number
HU0001403A
Other languages
English (en)
Inventor
R. Thomas Crane
Original Assignee
Ribi Immunochem Research, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ribi Immunochem Research, Inc. filed Critical Ribi Immunochem Research, Inc.
Publication of HUP0001403A2 publication Critical patent/HUP0001403A2/hu
Publication of HUP0001403A3 publication Critical patent/HUP0001403A3/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • C07H13/06—Fatty acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mycology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Pulmonology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

A gyengített lipid-A származékőt és felületaktív anyagőt vagyfelületaktív anyagőkat tartalmazó vizes adjűváns összetétel amelegvérű állatőkban egy fehérje antigénnel szembeni imműnőlógiaiválaszt megnöveli. A jelen találmány szerinti gyengített lipid-Aszármazékők közé a mőnőfőszfőril-lipid-A és a 3-O-deacilezettmőnőfőszfőri-lipid-A tartőzik. A felületaktív anyagőt vagyfelületaktív anyagők keverékeit őldószerben felőldják. Az 1,2-dipalmitőil-sn-glicerő-3-főszfőkőlin az előnyben részesítettfelületaktív anyag. Az elegy kialakításáhőz a felőldőtt felületaktívanyagőt a gyengített lipid-A származékhőz hőzzáadják. A gyengítettlipid-A származék és a felületaktív anyag mőláris aránya körülbelül 4: 1. Az őldószert elpárőlőgtatják és a keletkezett filmhez vizetadnak. A szűszpenziót 60 řC-őn kitisztűlásáig szőnikálják. Az adjűvánskiszereléssel kezelt állatők az adőtt antigénnel szemben megnövekedettellenanyagválaszt műtattak, valamint a limfőciták prőliferációját és acitőtőxikűs T-limfőciták válaszait megnövelték. Egy antigén és a vizesadjűváns összetétel intranazális beadása a szérűm és a nyálkahártyákáltal szekretált IgA termelését stiműlálja. ŕ
HU0001403A 1997-04-01 1998-04-01 Aqueous immunologic adjuvant compositions of monophosphoryl lipid a HUP0001403A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US83107397A 1997-04-01 1997-04-01
PCT/US1998/006528 WO1998043670A2 (en) 1997-04-01 1998-04-01 Aqueous immunologic adjuvant compositions of monophosphoryl lipid a

Publications (2)

Publication Number Publication Date
HUP0001403A2 true HUP0001403A2 (hu) 2000-09-28
HUP0001403A3 HUP0001403A3 (en) 2003-05-28

Family

ID=25258229

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0001403A HUP0001403A3 (en) 1997-04-01 1998-04-01 Aqueous immunologic adjuvant compositions of monophosphoryl lipid a

Country Status (19)

Country Link
EP (1) EP0971739B1 (hu)
JP (1) JP5019494B2 (hu)
KR (1) KR100603884B1 (hu)
CN (2) CN1259052A (hu)
AT (1) ATE278419T1 (hu)
AU (1) AU743114B2 (hu)
BR (1) BR9811262A (hu)
CA (1) CA2284586C (hu)
DE (1) DE69826842T2 (hu)
ES (1) ES2227825T3 (hu)
HK (1) HK1026613A1 (hu)
HU (1) HUP0001403A3 (hu)
IL (2) IL132126A0 (hu)
NO (1) NO994760L (hu)
NZ (1) NZ338101A (hu)
PL (1) PL190237B1 (hu)
PT (1) PT971739E (hu)
TR (1) TR199902437T2 (hu)
WO (1) WO1998043670A2 (hu)

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Also Published As

Publication number Publication date
HK1026613A1 (en) 2000-12-22
AU6947398A (en) 1998-10-22
PL190237B1 (pl) 2005-11-30
IL132126A0 (en) 2001-03-19
ES2227825T3 (es) 2005-04-01
ATE278419T1 (de) 2004-10-15
NZ338101A (en) 2002-03-28
EP0971739A2 (en) 2000-01-19
CA2284586A1 (en) 1998-10-08
CA2284586C (en) 2011-02-08
EP0971739B1 (en) 2004-10-06
CN1259052A (zh) 2000-07-05
CN1575815A (zh) 2005-02-09
NO994760D0 (no) 1999-09-30
IL132126A (en) 2006-10-05
DE69826842D1 (de) 2004-11-11
HUP0001403A3 (en) 2003-05-28
KR20010005882A (ko) 2001-01-15
WO1998043670A3 (en) 1998-12-30
PL336698A1 (en) 2000-07-03
TR199902437T2 (xx) 2000-01-21
JP5019494B2 (ja) 2012-09-05
DE69826842T2 (de) 2005-11-24
JP2001526640A (ja) 2001-12-18
WO1998043670A2 (en) 1998-10-08
NO994760L (no) 1999-11-26
PT971739E (pt) 2004-12-31
KR100603884B1 (ko) 2006-07-24
AU743114B2 (en) 2002-01-17
CN1326564C (zh) 2007-07-18
BR9811262A (pt) 2000-10-17

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