IE40122B1 - Preparation of 7-acylamino cephalosporin derivatives - Google Patents
Preparation of 7-acylamino cephalosporin derivativesInfo
- Publication number
- IE40122B1 IE40122B1 IE2366/74A IE236674A IE40122B1 IE 40122 B1 IE40122 B1 IE 40122B1 IE 2366/74 A IE2366/74 A IE 2366/74A IE 236674 A IE236674 A IE 236674A IE 40122 B1 IE40122 B1 IE 40122B1
- Authority
- IE
- Ireland
- Prior art keywords
- group
- preparation
- derivative
- cephalosporin derivatives
- acylamino
- Prior art date
Links
- 229930186147 Cephalosporin Natural products 0.000 title 1
- 229940124587 cephalosporin Drugs 0.000 title 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 229940088710 antibiotic agent Drugs 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 150000001782 cephems Chemical class 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004185 ester group Chemical group 0.000 abstract 1
- 239000002808 molecular sieve Substances 0.000 abstract 1
- 125000006239 protecting group Chemical group 0.000 abstract 1
- URGAHOPLAPQHLN-UHFFFAOYSA-N sodium aluminosilicate Chemical compound [Na+].[Al+3].[O-][Si]([O-])=O.[O-][Si]([O-])=O URGAHOPLAPQHLN-UHFFFAOYSA-N 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/02—Preparation
- C07D501/04—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/02—Preparation
- C07D501/04—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
- C07D501/06—Acylation of 7-aminocephalosporanic acid
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Cephalosporin Compounds (AREA)
Abstract
Cephem derivatives of the following formula <IMAGE> in which the substituents are defined in Claim 1, are prepared by a novel process. In this process, an appropriate 7-acylamidocephem derivative having a protected carboxyl group in the 4-position is reacted in the presence of a molecular sieve with an acylating agent donating the desired acyl radical. The original acyl group is removed from the initially resulting 7-diacylamidocephem derivative. The free acid is obtained by removal of the protective group R'', which preferably represents an easily removable ester group. The said compounds are used as antibiotics.
[GB1480757A]
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US42041873A | 1973-11-30 | 1973-11-30 | |
| US50747374A | 1974-09-23 | 1974-09-23 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE40122L IE40122L (en) | 1975-05-30 |
| IE40122B1 true IE40122B1 (en) | 1979-03-14 |
Family
ID=27024839
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE2366/74A IE40122B1 (en) | 1973-11-30 | 1974-11-18 | Preparation of 7-acylamino cephalosporin derivatives |
Country Status (18)
| Country | Link |
|---|---|
| JP (1) | JPS6020393B2 (en) |
| AR (1) | AR211234A1 (en) |
| CA (1) | CA1041481A (en) |
| CH (1) | CH618443A5 (en) |
| DD (1) | DD115125A5 (en) |
| DE (1) | DE2456528C2 (en) |
| DK (1) | DK153154C (en) |
| ES (1) | ES432305A1 (en) |
| FI (1) | FI60210C (en) |
| FR (1) | FR2253022B1 (en) |
| GB (1) | GB1480757A (en) |
| HU (1) | HU168823B (en) |
| IE (1) | IE40122B1 (en) |
| IT (1) | IT1043920B (en) |
| NL (1) | NL187023C (en) |
| NO (1) | NO147839C (en) |
| SE (1) | SE432934B (en) |
| YU (1) | YU36736B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS56158790A (en) * | 1980-05-14 | 1981-12-07 | Sankyo Co Ltd | Preparation of cephalosporin derivative |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2127225A1 (en) * | 1970-06-12 | 1971-12-16 | Yamanouchi Pharmaceutical Co Ltd , Tokio | New process for making cephalexin |
| US3843639A (en) * | 1973-02-08 | 1974-10-22 | Bristol Myers Co | Production of cephalexin via methoxymethyl ester |
-
1974
- 1974-11-13 DK DK589474A patent/DK153154C/en not_active IP Right Cessation
- 1974-11-13 SE SE7414249A patent/SE432934B/en not_active IP Right Cessation
- 1974-11-13 NL NLAANVRAGE7414820,A patent/NL187023C/en not_active IP Right Cessation
- 1974-11-14 FI FI3301/74A patent/FI60210C/en active
- 1974-11-14 NO NO744088A patent/NO147839C/en unknown
- 1974-11-18 IE IE2366/74A patent/IE40122B1/en unknown
- 1974-11-21 YU YU3104/74A patent/YU36736B/en unknown
- 1974-11-25 GB GB50969/74A patent/GB1480757A/en not_active Expired
- 1974-11-25 CA CA214,541A patent/CA1041481A/en not_active Expired
- 1974-11-26 ES ES432305A patent/ES432305A1/en not_active Expired
- 1974-11-27 AR AR256686A patent/AR211234A1/en active
- 1974-11-27 DD DD182615A patent/DD115125A5/xx unknown
- 1974-11-28 IT IT54286/74A patent/IT1043920B/en active
- 1974-11-28 CH CH1580874A patent/CH618443A5/en not_active IP Right Cessation
- 1974-11-28 FR FR7439044A patent/FR2253022B1/fr not_active Expired
- 1974-11-29 DE DE2456528A patent/DE2456528C2/en not_active Expired
- 1974-11-29 HU HUME1803A patent/HU168823B/hu unknown
- 1974-11-30 JP JP49136660A patent/JPS6020393B2/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| CA1041481A (en) | 1978-10-31 |
| YU36736B (en) | 1984-08-31 |
| YU310474A (en) | 1981-11-13 |
| FI60210B (en) | 1981-08-31 |
| ES432305A1 (en) | 1977-06-16 |
| DK153154B (en) | 1988-06-20 |
| IE40122L (en) | 1975-05-30 |
| SE7414249L (en) | 1975-06-02 |
| JPS6020393B2 (en) | 1985-05-21 |
| CH618443A5 (en) | 1980-07-31 |
| DK589474A (en) | 1975-07-28 |
| JPS50105687A (en) | 1975-08-20 |
| SE432934B (en) | 1984-04-30 |
| IT1043920B (en) | 1980-02-29 |
| HU168823B (en) | 1976-07-28 |
| NO147839C (en) | 1983-06-22 |
| AR211234A1 (en) | 1977-11-15 |
| DE2456528C2 (en) | 1986-01-16 |
| GB1480757A (en) | 1977-07-27 |
| NO147839B (en) | 1983-03-14 |
| NO744088L (en) | 1975-06-23 |
| DE2456528A1 (en) | 1975-06-05 |
| NL187023C (en) | 1991-05-01 |
| FI330174A7 (en) | 1975-05-31 |
| AU7550474A (en) | 1976-05-20 |
| NL187023B (en) | 1990-12-03 |
| NL7414820A (en) | 1975-06-03 |
| FR2253022A1 (en) | 1975-06-27 |
| DK153154C (en) | 1988-10-24 |
| FI60210C (en) | 1981-12-10 |
| DD115125A5 (en) | 1975-09-12 |
| FR2253022B1 (en) | 1978-07-07 |
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