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HUP0300413A2 - Amidcsoportot viselő benzolgyűrűs csoporttal helyettesített piperidint tartalmazó és rokonszerkezetű vegyületek, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények - Google Patents

Amidcsoportot viselő benzolgyűrűs csoporttal helyettesített piperidint tartalmazó és rokonszerkezetű vegyületek, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények

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Publication number
HUP0300413A2
HUP0300413A2 HU0300413A HUP0300413A HUP0300413A2 HU P0300413 A2 HUP0300413 A2 HU P0300413A2 HU 0300413 A HU0300413 A HU 0300413A HU P0300413 A HUP0300413 A HU P0300413A HU P0300413 A2 HUP0300413 A2 HU P0300413A2
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HU
Hungary
Prior art keywords
group
formula
substituted
alkyl
general formula
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HU0300413A
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English (en)
Inventor
Eric Platt Arnold
Thomas Allen Chappie
Jianhua Huang
John Michael Humphrey
Arthur Adam Nagel
Brian Thomas O'neill
Susan Beth Sobolov-Jaynes
Lawrence Albert Vincent
Original Assignee
Pfizer Products Inc.
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Application filed by Pfizer Products Inc. filed Critical Pfizer Products Inc.
Publication of HUP0300413A2 publication Critical patent/HUP0300413A2/hu

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Abstract

(I), (II) és (T-NH2) általános képletű vegyületek, ezek sói, valamintaz (I) általános képletű vegyületeket vagy gyógyászatilag elfogadhatósóikat tartalmazó gyógyászati készítmények, valamint eljárás az (I)általános képletű vegyületek vagy sóik alkalmazására gyógyászatikészítmények előállításánál, ahol az (I) és (II) általános képletben,továbbá a (T-NH2) általános képletű vegyületek helyén szereplő (Va)általános képletű vegyületek képletében Q jelentése -C(=NH)- képletűimino-metilén-csoport, -C(=CH2)- képletű etén-1,1-diil-csoport, -C(=S)- képletű tiokarbonilcsoport, -C(=O)- képletű karbonilcsoport, -S(O)- képletű szulfinilcsoport vagy -S(O2)- képletű szulfonilcsoport;A jelentése adott esetben alkilcsoporttal vagy trifluor-metil-csoporttal helyettesített metincsoport vagy metiléncsoport; Bjelentése metiléncsoport vagy etiléncsoport, vagy nincs jelen amolekulában; Y és Z jelentése nitrogénatom vagy metincsoport, de nemegyidejűleg nitrogénatom; G jelentése NH(CH2)q, S(CH2)q, vagy O(CH2)qáltalános képletű csoport, ahol q jelentése 0 vagy 1; W jelentése 1-3szénatomos, telített vagy telítetlen szénhidrogén-csoport, amely R6és/vagy R7 csoporttal helyettesített lehet, vagy egy szénlánccalegyütt egy spirogyűrűt vagy kondenzált gyűrűt képezhet; p jelentése 0,1 vagy 2; R1, R2, R11, R12 és R13 jelentése hidrogénatom vagyalkilcsoport, amely hidroxilcsoporttal, oxocsoporttal,alkoxicsoporttal és/vagy cianocsoporttal helyettesített lehet; R3jelentése hidrogénatom, COR9 vagy CO2R9 általános képletű csoport;fenilcsoport, amely halogénatommal, cianocsoporttal, nitrocsoporttal,trifluor-metil-csoporttal, (CH2)mNR9R10 (ahol m jelentése 0, 1 vagy2), NR9COR10, NR9CO2R10, CONR9R10, CO2NR9R10, COR9 vagy CO2R9általános képletű csoporttal és/vagy - adott esetben fluorozott -alkilcsoporttal, alkoxicsoporttal és/vagy alkenilcsoporttalhelyettesített lehet; telített vagy telítetlen, 1-4 heteroatomot(oxigénatomot, nitrogénatomot és/vagy kénatomot) tartalmazó, 3-7-tagúmonociklusos vagy 8-12-tagú biciklusos heterociklusos csoport, amelyhelyettesített lehet; vagy alkilcsoport, amely a szénláncba ékelvetartalmazhat valamely fenti heteroatomot, és helyettesített lehet;vagy R1 és R2, vagy R2 és R3, vagy pedig R12 és R13 együtt, a hozzájukkapcsolódó atomokkal együtt, 5- vagy 6-tagú heterociklusos vagykarbociklusos csoportot képeznek, amely helyettesített lehet; vagy R4jelentése fenilcsoport, piridilcsoport, tienilcsoport vagypirimidinilcsoport, amely helyettesített lehet; R5 és R8 jelentésehidrogénatom, alkil- vagy arilszulfinilcsoport, alkil- vagyarilszulfonilcsoport, trifluor-metil-csoport, halogénatom, adottesetben halogénatommal, hidroxilcsoporttal vagy - adott esetbenfluorozott - alkoxicsoporttal vagy alkilcsoporttal helyettesítettfenilcsoport, fenil-alkil-csoport, hidroxilcsoport, ari
HU0300413A 2000-04-10 2001-04-06 Amidcsoportot viselő benzolgyűrűs csoporttal helyettesített piperidint tartalmazó és rokonszerkezetű vegyületek, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények HUP0300413A2 (hu)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US19592200P 2000-04-10 2000-04-10
US21292200P 2000-06-20 2000-06-20
PCT/IB2001/000629 WO2001077100A2 (en) 2000-04-10 2001-04-06 Benzoamide piperidine compounds as substance p antagonists

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HUP0300413A2 true HUP0300413A2 (hu) 2003-06-28

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EP (1) EP1272484B1 (hu)
JP (1) JP4001486B2 (hu)
KR (1) KR20020087134A (hu)
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