HUP0101025A1 - 1-Metil-5-p-toluoilpirrol-2-acetamidoecetsav-gvajakonil-észter új kristályos polimorf formája - Google Patents
1-Metil-5-p-toluoilpirrol-2-acetamidoecetsav-gvajakonil-észter új kristályos polimorf formájaInfo
- Publication number
- HUP0101025A1 HUP0101025A1 HU0101025A HUP0101025A HUP0101025A1 HU P0101025 A1 HUP0101025 A1 HU P0101025A1 HU 0101025 A HU0101025 A HU 0101025A HU P0101025 A HUP0101025 A HU P0101025A HU P0101025 A1 HUP0101025 A1 HU P0101025A1
- Authority
- HU
- Hungary
- Prior art keywords
- toluoylpyrrole
- methyl
- polymorphic form
- new crystalline
- crystalline polymorphic
- Prior art date
Links
- GZQHOTPDLORUIU-UHFFFAOYSA-N 2-acetamidoacetic acid;(4-methylphenyl)-(1-methylpyrrol-2-yl)methanone Chemical compound CC(=O)NCC(O)=O.C1=CC(C)=CC=C1C(=O)C1=CC=CN1C GZQHOTPDLORUIU-UHFFFAOYSA-N 0.000 title abstract 2
- 150000002148 esters Chemical class 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 3
- CWJNMKKMGIAGDK-UHFFFAOYSA-N amtolmetin guacil Chemical compound COC1=CC=CC=C1OC(=O)CNC(=O)CC(N1C)=CC=C1C(=O)C1=CC=C(C)C=C1 CWJNMKKMGIAGDK-UHFFFAOYSA-N 0.000 abstract 2
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 230000001754 anti-pyretic effect Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000012986 modification Methods 0.000 abstract 1
- 230000004048 modification Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/323—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to the ring nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pain & Pain Management (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyrrole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Peptides Or Proteins (AREA)
Abstract
A találmány az (I) képletű 1-metil-5-p-toluoilpirrol-2-acet-amidoecetsav-gvajakonil-észter új, polimorf kristályos módosulatáravonatkozik, e vegyületet MED 15, 2 formaként jelöljük. A találmányoltalmi körébe tartozik továbbá a MED 15, 2 forma vegyület előállításieljárása is. A fenti vegyület gyulladásgátló, analgetikus éslázcsillapító hatású. Ó
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT97RM000811A IT1297140B1 (it) | 1997-12-24 | 1997-12-24 | Forma cristallina del guaiacil estere dell'acido l-metil-5-p-toluoil- pirrol-2-acetammidoacetico, procedimento per la sua preparazione e |
| PCT/IT1998/000363 WO1999033797A1 (en) | 1997-12-24 | 1998-12-16 | NEW CRYSTALLINE POLYMORPHIC FORM OF 1-METHYL-5-p-TOLUOYLPYRROLE-2-ACETAMIDOACETIC ACID GUAIACYL ESTER (MED 15) |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| HUP0101025A1 true HUP0101025A1 (hu) | 2001-08-28 |
| HUP0101025A3 HUP0101025A3 (en) | 2001-09-28 |
| HU228112B1 HU228112B1 (en) | 2012-11-28 |
Family
ID=11405418
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0101025A HU228112B1 (en) | 1997-12-24 | 1998-12-16 | New crystalline polymorphic form of 1-methyl-5-p-toluoylpyrrole-2-acetamidoacetic acid guaiacyl ester |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US6288241B1 (hu) |
| EP (1) | EP1082304B1 (hu) |
| JP (1) | JP4693236B2 (hu) |
| KR (1) | KR100554704B1 (hu) |
| CN (1) | CN1200930C (hu) |
| AT (1) | ATE255562T1 (hu) |
| AU (1) | AU781283B2 (hu) |
| BR (1) | BR9814476A (hu) |
| CA (1) | CA2315835C (hu) |
| CZ (1) | CZ297132B6 (hu) |
| DE (1) | DE69820301T2 (hu) |
| DK (1) | DK1082304T3 (hu) |
| ES (1) | ES2210853T3 (hu) |
| HK (1) | HK1035717A1 (hu) |
| HU (1) | HU228112B1 (hu) |
| IL (1) | IL136828A (hu) |
| IT (1) | IT1297140B1 (hu) |
| PL (1) | PL197768B1 (hu) |
| PT (1) | PT1082304E (hu) |
| SK (1) | SK284777B6 (hu) |
| TR (1) | TR200001867T2 (hu) |
| WO (1) | WO1999033797A1 (hu) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPWO2020175023A1 (ja) * | 2019-02-28 | 2021-12-16 | 国立大学法人東京工業大学 | アミドの製造方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1210673B (it) * | 1982-02-26 | 1989-09-20 | Medosan Ind Biochimi | Antinfiammatoria amidi pirrolacetiche ad attivita' |
| IT1148117B (it) * | 1982-03-05 | 1986-11-26 | Medosan Ind Biochimi | Attivita'antiflogistica,analgesica,antipiretica,mucolitica e seda tiva della tosse dell'1 metil-5-p-tolilpirrol-2-acetato di 2'metossi-fenile |
| IT1197688B (it) * | 1983-07-29 | 1988-12-06 | Medosan Ind Biochimi | Attivita' antiflogistica,analgesica,antipiretica ed antiaggregante piastrinica di 1-metil-5-metilbenzoilpirrol-2-acetamido acetanilidi |
| IT1278144B1 (it) * | 1995-07-14 | 1997-11-17 | Medosan Ricerca Srl | Impiego dell'amtolmetineguacil (med 15) come farmaco antisecretivo sulla secrezione gastrica e quindi gastroprotettivo. |
| DE69721077T2 (de) * | 1997-08-08 | 2004-02-05 | Medosan Ricerca S.R.L. | Verwendung von 2-methoxyphenyl-1-methyl-5p-methyl-benzoylpyrrol-2-acetamido-acetat zur herstellung eines antientzündungsmittels mit vorbeugung von magenhypersekretion und nierenfunktionsstörung |
-
1997
- 1997-12-24 IT IT97RM000811A patent/IT1297140B1/it active IP Right Grant
-
1998
- 1998-12-16 PL PL341424A patent/PL197768B1/pl unknown
- 1998-12-16 IL IL13682898A patent/IL136828A/xx not_active IP Right Cessation
- 1998-12-16 DK DK98962664T patent/DK1082304T3/da active
- 1998-12-16 ES ES98962664T patent/ES2210853T3/es not_active Expired - Lifetime
- 1998-12-16 CZ CZ20002336A patent/CZ297132B6/cs not_active IP Right Cessation
- 1998-12-16 AT AT98962664T patent/ATE255562T1/de active
- 1998-12-16 CA CA002315835A patent/CA2315835C/en not_active Expired - Lifetime
- 1998-12-16 TR TR2000/01867T patent/TR200001867T2/xx unknown
- 1998-12-16 SK SK895-2000A patent/SK284777B6/sk not_active IP Right Cessation
- 1998-12-16 JP JP2000526481A patent/JP4693236B2/ja not_active Expired - Lifetime
- 1998-12-16 DE DE69820301T patent/DE69820301T2/de not_active Expired - Lifetime
- 1998-12-16 PT PT98962664T patent/PT1082304E/pt unknown
- 1998-12-16 BR BR9814476-6A patent/BR9814476A/pt not_active Application Discontinuation
- 1998-12-16 KR KR1020007006998A patent/KR100554704B1/ko not_active IP Right Cessation
- 1998-12-16 HU HU0101025A patent/HU228112B1/hu unknown
- 1998-12-16 AU AU17828/99A patent/AU781283B2/en not_active Expired
- 1998-12-16 EP EP98962664A patent/EP1082304B1/en not_active Expired - Lifetime
- 1998-12-16 WO PCT/IT1998/000363 patent/WO1999033797A1/en active IP Right Grant
- 1998-12-16 CN CNB988126567A patent/CN1200930C/zh not_active Expired - Lifetime
- 1998-12-16 US US09/581,289 patent/US6288241B1/en not_active Expired - Lifetime
-
2001
- 2001-07-10 HK HK01104771A patent/HK1035717A1/xx not_active IP Right Cessation
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HUP0004250A2 (hu) | Hidroxi-ecetsav-észter származékok, előállítási eljárásuk és alkalmazásuk szintézis intermedierekként | |
| DE69711391D1 (de) | Verbessertes verfahren zum herstellen von geschützten 3,4-dihydroxybuttersäure estern | |
| MX9701893A (es) | Nuevos inhibidores de la prostaglandinsintasa. | |
| BR0109048A (pt) | Processo para a sìntese de citalopram | |
| NO20020515L (no) | Fremgangsmåte for fremstilling av naproxen-nitroksyalkyl- estere | |
| DK1129087T3 (da) | Fremgangsmåde til racemisering | |
| HUP0101025A1 (hu) | 1-Metil-5-p-toluoilpirrol-2-acetamidoecetsav-gvajakonil-észter új kristályos polimorf formája | |
| ID16840A (id) | Proses perbaikan untuk produksi asam azetidina-2-karboksilat yang murni secara enentioner | |
| HUP0301010A2 (hu) | A koleszteril-észter és a viaszészter szintézisét egyaránt gátló vegyületek faggyúmirigy-betegségek kezeléséhez és ezeket tartalmazó gyógyszerkészítmények | |
| HUP0102348A2 (hu) | Új eljárás szintézis-intermedierek előállítására | |
| IL153830A0 (en) | A PROCESS FOR THE PREPARATION OF alpha' CHLOROKETONES | |
| FI861947A (fi) | Hexensyror. | |
| AU6152796A (en) | Syntheses of optically pure compounds useful as garft inhibi tors and their intermediates | |
| PT971899E (pt) | Compostos de hexa-hidroindenopiridina possuindo actividade antiespermatogenica. | |
| HUP9903773A2 (hu) | Eljárás metoxi-imino-fenil-glioxilsav-származékok előállítására | |
| TR200200307T2 (tr) | Alfa-Kloroepoksi esterleri vasıtasıyla asit hazırlama prosesi | |
| WO2001092251A3 (en) | Aryloxy ester and acid compounds | |
| BR9910603A (pt) | Método aprimorado paraa preparar derivados de norbenzomorfano valiosos farmaceuticamente | |
| YU34303A (sh) | Postupak za proizvodnju 4-(17alfa-supstituisani-3-oksoestra -4,9-dien-11beta-il)benzaldehid-(1e ili 1z)-oksima | |
| DE69634203D1 (de) | Cis-9,10-octadecenoamidase | |
| HUP9800614A2 (hu) | Eljárás 1,3-dioxán-vegyületek előállítására | |
| ATE247632T1 (de) | Verfahren zur herstellung von cyanessigsäureestern | |
| PT1163257E (pt) | Processo para o fabrico de esteres do acido 4,4-dimetil-3beta-hidroxipregna-8,14-dieno-21 carboxilico | |
| HUP0300348A2 (hu) | Eljárás (aril-imino-metil)-karbamidsav-észterek előállítására | |
| HUP0203381A2 (hu) | 5-Halogén-4-fluor-4,7,7-trimetil-3-oxabiciklo[4.1.0]heptan-2-on, eljárás előállítására és alkalmazása ciklopropán-karbonsavak előállítására |