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BR112023004819A2 - Composições de vacinas multivalentes e seus usos - Google Patents

Composições de vacinas multivalentes e seus usos

Info

Publication number
BR112023004819A2
BR112023004819A2 BR112023004819A BR112023004819A BR112023004819A2 BR 112023004819 A2 BR112023004819 A2 BR 112023004819A2 BR 112023004819 A BR112023004819 A BR 112023004819A BR 112023004819 A BR112023004819 A BR 112023004819A BR 112023004819 A2 BR112023004819 A2 BR 112023004819A2
Authority
BR
Brazil
Prior art keywords
compositions
expec
multivalent vaccine
vaccine compositions
methods
Prior art date
Application number
BR112023004819A
Other languages
English (en)
Inventor
Theunis Poolman Jan
Cristhina Fae Kellen
Sarnecki Michal
GEURTSEN Jeroen
Robert Abbanat Darren
Gustaaf M Spiessens Bart
Germaine F Struyf Frank
Original Assignee
Janssen Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceuticals Inc filed Critical Janssen Pharmaceuticals Inc
Publication of BR112023004819A2 publication Critical patent/BR112023004819A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/025—Enterobacteriales, e.g. Enterobacter
    • A61K39/0258—Escherichia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/739—Lipopolysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/6415—Toxins or lectins, e.g. clostridial toxins or Pseudomonas exotoxins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55583—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/70—Multivalent vaccine
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • Virology (AREA)
  • Toxicology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

COMPOSIÇÕES DE VACINAS MULTIVALENTES E SEUS USOS. São descritas composições e métodos para induzir uma resposta imune contra Escherichia coli patogênica extraintestinal (ExPEC) para, desse modo, proporcionar proteção imune contra doenças associadas a ExPEC. Em particular, são descritas composições e métodos para usar conjugados de polissacarídeo antigênico O75 de E. coli covalentemente ligado a uma proteína transportadora para a prevenção de doença por ExPEC invasiva.
BR112023004819A 2020-09-17 2021-09-17 Composições de vacinas multivalentes e seus usos BR112023004819A2 (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US202063079734P 2020-09-17 2020-09-17
EP21154782 2021-02-02
US202163191471P 2021-05-21 2021-05-21
PCT/IB2021/058485 WO2022058945A1 (en) 2020-09-17 2021-09-17 Multivalent vaccine compositions and uses thereof

Publications (1)

Publication Number Publication Date
BR112023004819A2 true BR112023004819A2 (pt) 2023-04-18

Family

ID=77801756

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112023004819A BR112023004819A2 (pt) 2020-09-17 2021-09-17 Composições de vacinas multivalentes e seus usos

Country Status (17)

Country Link
US (1) US20220088165A1 (pt)
EP (1) EP4213870A1 (pt)
JP (2) JP7481585B2 (pt)
KR (1) KR20230043157A (pt)
CN (1) CN115803087A (pt)
AU (1) AU2021342797B2 (pt)
BR (1) BR112023004819A2 (pt)
CA (1) CA3190820A1 (pt)
CL (1) CL2023000740A1 (pt)
CO (1) CO2023002114A2 (pt)
EC (1) ECSP23019295A (pt)
IL (2) IL301248B2 (pt)
MX (1) MX2023003169A (pt)
PE (1) PE20231385A1 (pt)
TW (1) TW202227128A (pt)
UY (1) UY39428A (pt)
WO (1) WO2022058945A1 (pt)

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PL3942028T3 (pl) 2019-03-18 2023-10-23 Janssen Pharmaceuticals, Inc. Sposób wytwarzania biokoniugatów polisacharydów antygenu O E. coli, zawierające je kompozycje oraz sposoby ich zastosowania
PE20212265A1 (es) 2019-03-18 2021-11-30 Janssen Pharmaceuticals Inc Bioconjugados de antigenos-polisacaridos de e. coli, metodos de produccion y metodos de utilizacion de los mismos
WO2024107729A2 (en) * 2022-11-15 2024-05-23 Janssen Pharmaceuticals, Inc. Multivalent vaccine compositions and uses thereof
WO2024146325A1 (zh) * 2023-01-06 2024-07-11 中国人民解放军军事科学院军事医学研究院 用于生产抗原多糖-载体蛋白生物偶联产物的工程菌及其应用
GB202302579D0 (en) * 2023-02-23 2023-04-12 Glaxosmithkline Biologicals Sa Immunogenic composition
WO2024186262A1 (en) * 2023-03-03 2024-09-12 Agency For Science, Technology And Research Use of o-antigens for treating bacterial infections

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Also Published As

Publication number Publication date
MX2023003169A (es) 2023-03-27
JP2023539943A (ja) 2023-09-20
IL301248B1 (en) 2023-12-01
WO2022058945A1 (en) 2022-03-24
US20220088165A1 (en) 2022-03-24
KR20230043157A (ko) 2023-03-30
JP2024099716A (ja) 2024-07-25
IL308201A (en) 2024-01-01
ECSP23019295A (es) 2023-04-28
EP4213870A1 (en) 2023-07-26
TW202227128A (zh) 2022-07-16
IL301248A (en) 2023-05-01
AU2021342797B2 (en) 2024-02-08
JP7481585B2 (ja) 2024-05-10
CO2023002114A2 (es) 2023-03-07
CA3190820A1 (en) 2022-03-24
CL2023000740A1 (es) 2023-09-29
UY39428A (es) 2022-03-31
CN115803087A (zh) 2023-03-14
PE20231385A1 (es) 2023-09-12
IL301248B2 (en) 2024-04-01
AU2021342797A1 (en) 2023-02-16

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