HUP0000547A3 - Zinc free insulin crystals for use in pulmonary compositions - Google Patents
Zinc free insulin crystals for use in pulmonary compositionsInfo
- Publication number
- HUP0000547A3 HUP0000547A3 HU0000547A HUP0000547A HUP0000547A3 HU P0000547 A3 HUP0000547 A3 HU P0000547A3 HU 0000547 A HU0000547 A HU 0000547A HU P0000547 A HUP0000547 A HU P0000547A HU P0000547 A3 HUP0000547 A3 HU P0000547A3
- Authority
- HU
- Hungary
- Prior art keywords
- free insulin
- insulin crystals
- zinc free
- pulmonary compositions
- pulmonary
- Prior art date
Links
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title 2
- 102000004877 Insulin Human genes 0.000 title 1
- 108090001061 Insulin Proteins 0.000 title 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 title 1
- 239000013078 crystal Substances 0.000 title 1
- 229940125396 insulin Drugs 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 230000002685 pulmonary effect Effects 0.000 title 1
- 239000011701 zinc Substances 0.000 title 1
- 229910052725 zinc Inorganic materials 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Endocrinology (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Otolaryngology (AREA)
- Pulmonology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK31797 | 1997-03-20 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0000547A2 HUP0000547A2 (hu) | 2000-08-28 |
| HUP0000547A3 true HUP0000547A3 (en) | 2002-11-28 |
Family
ID=8092195
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0000547A HUP0000547A3 (en) | 1997-03-20 | 1998-03-20 | Zinc free insulin crystals for use in pulmonary compositions |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US20070093411A1 (hu) |
| EP (2) | EP1627642A3 (hu) |
| JP (1) | JP3764174B2 (hu) |
| KR (1) | KR20000076419A (hu) |
| CN (1) | CN1259142A (hu) |
| AT (1) | ATE321783T1 (hu) |
| AU (1) | AU742591B2 (hu) |
| BR (1) | BR9808285A (hu) |
| CA (1) | CA2283705A1 (hu) |
| DE (1) | DE69834028T2 (hu) |
| ES (1) | ES2260832T3 (hu) |
| HU (1) | HUP0000547A3 (hu) |
| IL (1) | IL131796A0 (hu) |
| NO (1) | NO994520L (hu) |
| PL (1) | PL335777A1 (hu) |
| RU (1) | RU2198181C2 (hu) |
| WO (1) | WO1998042749A1 (hu) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6500933B1 (en) | 1997-09-05 | 2002-12-31 | Altus Biologics Inc. | Methods of preparing carbohydrate crosslinked glycoprotein crystals |
| DE69839563D1 (de) | 1997-09-05 | 2008-07-10 | Altus Pharmaceuticals Inc | Kohlenhydrat-vernetzte glykoproteinkristalle |
| ZA989744B (en) * | 1997-10-31 | 2000-04-26 | Lilly Co Eli | Method for administering acylated insulin. |
| US6541606B2 (en) | 1997-12-31 | 2003-04-01 | Altus Biologics Inc. | Stabilized protein crystals formulations containing them and methods of making them |
| JP4965022B2 (ja) * | 1998-04-27 | 2012-07-04 | アルタス ファーマシューティカルズ インコーポレイテッド | 安定化されたタンパク質結晶、それを含む処方物、およびそれを作製する方法 |
| EP2311436A1 (en) | 1998-04-27 | 2011-04-20 | Altus Pharmaceuticals Inc. | Stabilized protein crystals, formulations containing them and methods of making them |
| DE19903125B4 (de) * | 1999-01-27 | 2006-01-05 | Sanofi-Aventis Deutschland Gmbh | Verfahren zur Trocknung von Kristallen von Insulin oder Insulinanaloga |
| WO2000064940A1 (en) * | 1999-04-27 | 2000-11-02 | Eli Lilly And Company | Insulin crystals for pulmonary administration |
| GB0011807D0 (en) * | 2000-05-16 | 2000-07-05 | Quadrant Holdings Cambridge | Formulation for inhalation |
| DE10114178A1 (de) * | 2001-03-23 | 2002-10-10 | Aventis Pharma Gmbh | Zinkfreie und zinkarme Insulinzubereitungen mit verbesserter Stabilität |
| DE10227232A1 (de) | 2002-06-18 | 2004-01-15 | Aventis Pharma Deutschland Gmbh | Saure Insulinzubereitungen mit verbesserter Stabilität |
| DE10250297A1 (de) * | 2002-10-29 | 2004-05-19 | Aventis Pharma Deutschland Gmbh | Kristalle von Insulinanaloga und Verfahren zu ihrer Herstellung |
| US7193035B2 (en) | 2002-10-29 | 2007-03-20 | Sanofi-Aventis Deutschland Gmbh | Crystals of insulin analogs and processes for their preparation |
| JP4463814B2 (ja) * | 2003-08-05 | 2010-05-19 | ノボ ノルディスク アクティーゼルスカブ | 新規のインスリン誘導体 |
| JP4601627B2 (ja) | 2004-01-16 | 2010-12-22 | バイオデル， インコーポレイテッド | 舌下薬物送達デバイス |
| US20080090753A1 (en) | 2004-03-12 | 2008-04-17 | Biodel, Inc. | Rapid Acting Injectable Insulin Compositions |
| KR100798333B1 (ko) * | 2005-08-03 | 2008-01-28 | 고려대학교 산학협력단 | 락토오스 운반체와 혼합건조된 폐 전달용 인슐린미세결정분말 |
| KR101939557B1 (ko) | 2008-10-17 | 2019-01-17 | 사노피-아벤티스 도이칠란트 게엠베하 | 인슐린과 ｇｌｐ－1 효능제의 병용물 |
| US9060927B2 (en) | 2009-03-03 | 2015-06-23 | Biodel Inc. | Insulin formulations for rapid uptake |
| BR112012002934B1 (pt) * | 2009-08-11 | 2021-12-21 | Biocon Limited | Processos cromatográficos e seus compostos purificados |
| EP2554183B1 (de) | 2009-11-13 | 2018-04-04 | Sanofi-Aventis Deutschland GmbH | Pharmazeutische Zusammensetzung umfassend einen GLP-1-Agonisten, ein Insulin und Methionin |
| NZ599847A (en) | 2009-11-13 | 2013-09-27 | Sanofi Aventis Deutschland | Pharmaceutical composition comprising a glp-1 agonist and methionine |
| WO2012028172A1 (en) | 2010-08-30 | 2012-03-08 | Sanofi-Aventis Deutschland Gmbh | Use of ave0010 for the manufacture of a medicament for the treatment of diabetes mellitus type 2 |
| US9821032B2 (en) | 2011-05-13 | 2017-11-21 | Sanofi-Aventis Deutschland Gmbh | Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin |
| TWI608847B (zh) | 2011-08-29 | 2017-12-21 | 賽諾菲阿凡提斯德意志有限公司 | 用於控制糖尿病二型病患血糖的醫藥組合物 |
| TWI559929B (en) | 2011-09-01 | 2016-12-01 | Sanofi Aventis Deutschland | Pharmaceutical composition for use in the treatment of a neurodegenerative disease |
| AR099569A1 (es) | 2014-02-28 | 2016-08-03 | Novo Nordisk As | Derivados de insulina y los usos médicos de estos |
| BR112017000175B1 (pt) * | 2014-07-08 | 2023-11-21 | Amphastar Pharmaceuticals,Inc. | Método de preparação de uma insulina inalável adequada para a liberação pulmonar e partículas de insulina micronizadas |
| HUE062573T2 (hu) | 2014-12-12 | 2023-11-28 | Sanofi Aventis Deutschland | Glargin inzulin/lixiszenatid rögzített arányú készítmény |
| TWI748945B (zh) | 2015-03-13 | 2021-12-11 | 德商賽諾菲阿凡提斯德意志有限公司 | 第２型糖尿病病患治療 |
| TW201705975A (zh) | 2015-03-18 | 2017-02-16 | 賽諾菲阿凡提斯德意志有限公司 | 第２型糖尿病病患之治療 |
| CN104761632A (zh) * | 2015-04-14 | 2015-07-08 | 珠海联邦制药股份有限公司 | 一种地特胰岛素结晶的制备方法及应用 |
| CN106117345B (zh) * | 2015-05-05 | 2020-11-24 | 宜昌东阳光长江药业股份有限公司 | 一种制备甘精胰岛素结晶的方法 |
| WO2017032798A1 (en) | 2015-08-25 | 2017-03-02 | Novo Nordisk A/S | Novel insulin derivatives and the medical uses hereof |
| JP2018531899A (ja) | 2015-08-25 | 2018-11-01 | ノヴォ ノルディスク アー／エス | 新規インスリン誘導体及びその医学的使用 |
| EP3341401A1 (en) | 2015-08-25 | 2018-07-04 | Novo Nordisk A/S | Novel insulin derivatives and the medical uses hereof |
| US10322168B2 (en) * | 2016-01-07 | 2019-06-18 | Amphastar Pharmaceuticals, Inc. | High-purity inhalable particles of insulin and insulin analogues, and high-efficiency methods of manufacturing the same |
| CN106749616B (zh) * | 2016-12-19 | 2021-09-03 | 华润昂德生物药业有限公司 | B30位苏氨酸缺失人胰岛素晶体的制备方法 |
| CN109957001B (zh) * | 2017-12-26 | 2022-11-18 | 甘李药业股份有限公司 | 甘赖脯胰岛素结晶的制备方法 |
| PL238016B1 (pl) * | 2018-07-06 | 2021-06-28 | Bioton Spolka Akcyjna | Krystaliczna, bezcynkowa postać insuliny glargine i sposób jej otrzymywania |
| PE20221260A1 (es) | 2019-12-11 | 2022-08-16 | Novo Nordisk As | Analogos de insulina novedosos y usos de estos |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3719655A (en) * | 1969-12-05 | 1973-03-06 | Lilly Co Eli | Process for the crystallization of the ammonium and alkali metal salts in insulin |
| DE3327928A1 (de) * | 1983-08-03 | 1985-02-21 | Hoechst Ag, 6230 Frankfurt | Verfahren zur herstellung von insulin-derivaten |
| US5506203C1 (en) * | 1993-06-24 | 2001-02-06 | Astra Ab | Systemic administration of a therapeutic preparation |
| KR100310122B1 (ko) * | 1993-09-17 | 2002-04-24 | 한센 핀 베네드, 안네 제헤르, 웨이콥 마리안느 | 아실화된인슐린 |
| AU689217B2 (en) * | 1994-03-07 | 1998-03-26 | Novartis Ag | Methods and compositions for pulmonary delivery of insulin |
| JP3414539B2 (ja) * | 1994-05-11 | 2003-06-09 | 有限会社ドット | 経鼻吸収用組成物 |
| US5597893A (en) * | 1994-10-31 | 1997-01-28 | Eli Lilly And Company | Preparation of stable insulin analog crystals |
| US5700904A (en) * | 1995-06-07 | 1997-12-23 | Eli Lilly And Company | Preparation of an acylated protein powder |
| US5898067A (en) * | 1997-02-07 | 1999-04-27 | Novo Nordisk A/S | Crystallization of proteins |
| US6310038B1 (en) * | 1997-03-20 | 2001-10-30 | Novo Nordisk A/S | Pulmonary insulin crystals |
| DE10114178A1 (de) * | 2001-03-23 | 2002-10-10 | Aventis Pharma Gmbh | Zinkfreie und zinkarme Insulinzubereitungen mit verbesserter Stabilität |
-
1998
- 1998-03-20 ES ES98907916T patent/ES2260832T3/es not_active Expired - Lifetime
- 1998-03-20 RU RU99122036/04A patent/RU2198181C2/ru not_active IP Right Cessation
- 1998-03-20 PL PL98335777A patent/PL335777A1/xx unknown
- 1998-03-20 HU HU0000547A patent/HUP0000547A3/hu unknown
- 1998-03-20 AT AT98907916T patent/ATE321783T1/de not_active IP Right Cessation
- 1998-03-20 EP EP05109987A patent/EP1627642A3/en not_active Withdrawn
- 1998-03-20 CA CA002283705A patent/CA2283705A1/en not_active Abandoned
- 1998-03-20 EP EP98907916A patent/EP1005490B1/en not_active Expired - Lifetime
- 1998-03-20 CN CN98805938A patent/CN1259142A/zh active Pending
- 1998-03-20 AU AU66120/98A patent/AU742591B2/en not_active Ceased
- 1998-03-20 WO PCT/DK1998/000109 patent/WO1998042749A1/en active IP Right Grant
- 1998-03-20 DE DE69834028T patent/DE69834028T2/de not_active Expired - Lifetime
- 1998-03-20 KR KR1019997008523A patent/KR20000076419A/ko not_active Application Discontinuation
- 1998-03-20 BR BR9808285-0A patent/BR9808285A/pt not_active IP Right Cessation
- 1998-03-20 IL IL13179698A patent/IL131796A0/xx unknown
- 1998-03-20 JP JP54474798A patent/JP3764174B2/ja not_active Expired - Fee Related
-
1999
- 1999-09-17 NO NO994520A patent/NO994520L/no unknown
-
2006
- 2006-01-23 US US11/337,855 patent/US20070093411A1/en not_active Abandoned
-
2007
- 2007-07-06 US US11/774,027 patent/US20090311326A9/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| ES2260832T3 (es) | 2006-11-01 |
| KR20000076419A (ko) | 2000-12-26 |
| ATE321783T1 (de) | 2006-04-15 |
| EP1627642A2 (en) | 2006-02-22 |
| EP1005490A1 (en) | 2000-06-07 |
| CA2283705A1 (en) | 1998-10-01 |
| US20070093411A1 (en) | 2007-04-26 |
| NO994520D0 (no) | 1999-09-17 |
| JP3764174B2 (ja) | 2006-04-05 |
| NO994520L (no) | 1999-09-17 |
| DE69834028D1 (de) | 2006-05-18 |
| DE69834028T2 (de) | 2006-12-07 |
| EP1005490B1 (en) | 2006-03-29 |
| EP1627642A3 (en) | 2006-04-19 |
| AU6612098A (en) | 1998-10-20 |
| RU2198181C2 (ru) | 2003-02-10 |
| CN1259142A (zh) | 2000-07-05 |
| BR9808285A (pt) | 2000-05-16 |
| IL131796A0 (en) | 2001-03-19 |
| JP2001506272A (ja) | 2001-05-15 |
| AU742591B2 (en) | 2002-01-10 |
| WO1998042749A1 (en) | 1998-10-01 |
| US20090311326A9 (en) | 2009-12-17 |
| PL335777A1 (en) | 2000-05-22 |
| US20070292520A1 (en) | 2007-12-20 |
| HUP0000547A2 (hu) | 2000-08-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HUP0000547A3 (en) | Zinc free insulin crystals for use in pulmonary compositions | |
| HUP0104270A3 (en) | Herbicidal composition and use thereof | |
| EP1016400A4 (en) | COMPOSITION FOR EXTERNAL USE | |
| IL190220A0 (en) | Novel composition and use | |
| HUP9801167A3 (en) | Triaromatic compounds, compositions containing the same and use thereof | |
| ZA985096B (en) | Composition compound and use | |
| PL347357A1 (en) | Novel composition and use | |
| EP0965321A4 (en) | COMPOSITION FOR EXTERNAL USE | |
| EP0976407A4 (en) | ANTISEPTIC COMPOSITIONS | |
| GB9717598D0 (en) | Novel composition and use | |
| ZA982092B (en) | Improvements in or related to disinfectants | |
| PL334555A1 (en) | Novel fungicidal composition containing | |
| HUP0203721A3 (en) | Novel hormonal composition and the use thereof | |
| GB9708240D0 (en) | Improvements in or relating to contrast agents | |
| GB9803232D0 (en) | Compound composition and use | |
| GB2325954B (en) | Improvements in or relating to frames | |
| GB9717589D0 (en) | Improvements in or relating to contrast agents | |
| GB9701237D0 (en) | Improvements in or relating to contrast agents | |
| GB9927927D0 (en) | Compound composition and use | |
| GB9808581D0 (en) | Improvements in or relating to contrast agents | |
| GB9718636D0 (en) | Novel composition and use | |
| IL121719A0 (en) | Deicing composition | |
| GB9721373D0 (en) | Improvements in liquid compositions | |
| GB9922274D0 (en) | Improvements in or relating to fasteners | |
| PL340834A1 (en) | Monoglycerides containing compositions for use in agriculture |