HUP0401678A2 - 2-Amino-6-(2,4,5-szubsztituált-fenil)piridin-származékok és alkalmazásuk nitrogén(II)oxid szintáz inhibitorként és ezeket tartalmazó gyógyszerkészítmények - Google Patents
2-Amino-6-(2,4,5-szubsztituált-fenil)piridin-származékok és alkalmazásuk nitrogén(II)oxid szintáz inhibitorként és ezeket tartalmazó gyógyszerkészítményekInfo
- Publication number
- HUP0401678A2 HUP0401678A2 HU0401678A HUP0401678A HUP0401678A2 HU P0401678 A2 HUP0401678 A2 HU P0401678A2 HU 0401678 A HU0401678 A HU 0401678A HU P0401678 A HUP0401678 A HU P0401678A HU P0401678 A2 HUP0401678 A2 HU P0401678A2
- Authority
- HU
- Hungary
- Prior art keywords
- phenyl
- amino
- substituted
- methoxyphenyl
- ethyl
- Prior art date
Links
- 239000000236 nitric oxide synthase inhibitor Substances 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- CSYSULGPHGCBQD-UHFFFAOYSA-N s-ethylisothiouronium diethylphosphate Chemical compound CCSC(N)=N.CCOP(O)(=O)OCC CSYSULGPHGCBQD-UHFFFAOYSA-N 0.000 title 1
- ICSNLGPSRYBMBD-UHFFFAOYSA-N 2-aminopyridine Chemical compound NC1=CC=CC=N1 ICSNLGPSRYBMBD-UHFFFAOYSA-N 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 102000008299 Nitric Oxide Synthase Human genes 0.000 abstract 2
- 108010021487 Nitric Oxide Synthase Proteins 0.000 abstract 2
- 238000002360 preparation method Methods 0.000 abstract 2
- YDYQQWKQUILGSX-UHFFFAOYSA-N 6-[4-(azetidin-3-yloxy)-5-ethyl-2-methoxyphenyl]pyridin-2-amine Chemical compound CCC1=CC(C=2N=C(N)C=CC=2)=C(OC)C=C1OC1CNC1 YDYQQWKQUILGSX-UHFFFAOYSA-N 0.000 abstract 1
- BKULSIOVOCWIBT-UHFFFAOYSA-N 6-[4-[2-(dimethylamino)ethoxy]-5-ethyl-2-methoxyphenyl]pyridin-2-amine Chemical compound C1=C(OCCN(C)C)C(CC)=CC(C=2N=C(N)C=CC=2)=C1OC BKULSIOVOCWIBT-UHFFFAOYSA-N 0.000 abstract 1
- BEIVYOFXMAXJRH-UHFFFAOYSA-N 6-[5-ethyl-2-methoxy-4-(methylaminomethyl)phenyl]pyridin-2-amine Chemical compound C1=C(CNC)C(CC)=CC(C=2N=C(N)C=CC=2)=C1OC BEIVYOFXMAXJRH-UHFFFAOYSA-N 0.000 abstract 1
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 230000006806 disease prevention Effects 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/73—Unsubstituted amino or imino radicals
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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Abstract
A találmány új 2-amino-6-(2,4,5-szubsztituált-fenil)piridin-származékokra, ilyen vegyületeket tartalmazó gyógyászatikészítményekre, továbbá ezeknek a vegyületeknek a központiidegrendszer megbetegedései és más rendellenességek kezelésére ésmegelőzésére alkalmas gyógyászati készítmények előállítására valóalkalmazására vonatkozik. A találmány szerinti vegyületek mintnitrogén(II)oxid szintáz (NOS) inhibitorok hatnak. A találmányszerinti új 2-amino-6-(2,4,5-szubsztituált-fenil)piridin-származékok akövetkezők: 6[4-(N-metil-3-azetidinoxi)-5-etil-2-metoxifenil]piridin-2-il-amin; 6[4-(N,N-dimetilaminometil)-5-etil-2-metoxifenil]piridin-2-il-amin; 6-[4-(N-metilaminometil)-5-etil-2-metoxifenil]piridin-2-il-amin; 6-[4-(3-azetidinoxi)-5-etil-2-metoxifenil]piridin-2-il-amin; és6-[4-(2-dimetilaminoetoxi)-5-etil-2-metoxifenil]piridin-2-il-amin. Ó
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32825301P | 2001-10-10 | 2001-10-10 | |
| PCT/IB2002/003939 WO2003030993A1 (en) | 2001-10-10 | 2002-09-24 | 2-amino-6-(2,4,5-substituted-phenyl)-pyridines for use as nitric oxide synthase inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0401678A2 true HUP0401678A2 (hu) | 2004-12-28 |
| HUP0401678A3 HUP0401678A3 (en) | 2007-05-02 |
Family
ID=23280189
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0401678A HUP0401678A3 (en) | 2001-10-10 | 2002-09-24 | 2-amino-6-(2,4,5-substituted-phenyl)-pyridines for use as nitric oxide synthase inhibitors and pharmaceutical compositions containing them |
Country Status (36)
| Country | Link |
|---|---|
| EP (1) | EP1434624B1 (hu) |
| JP (1) | JP2005506337A (hu) |
| KR (1) | KR20040053157A (hu) |
| CN (1) | CN1568207A (hu) |
| AP (1) | AP2004003003A0 (hu) |
| AR (1) | AR036763A1 (hu) |
| AT (1) | ATE344089T1 (hu) |
| BG (1) | BG108669A (hu) |
| BR (1) | BR0213193A (hu) |
| CA (1) | CA2463364A1 (hu) |
| CZ (1) | CZ2004450A3 (hu) |
| DE (1) | DE60215837T2 (hu) |
| DO (1) | DOP2002000467A (hu) |
| EA (1) | EA007074B1 (hu) |
| EC (1) | ECSP045055A (hu) |
| EE (1) | EE200400085A (hu) |
| ES (1) | ES2275917T3 (hu) |
| GT (1) | GT200200206A (hu) |
| HN (1) | HN2002000289A (hu) |
| HR (1) | HRP20040260A2 (hu) |
| HU (1) | HUP0401678A3 (hu) |
| IL (1) | IL161089A0 (hu) |
| IS (1) | IS7171A (hu) |
| MA (1) | MA27074A1 (hu) |
| MX (1) | MXPA04002313A (hu) |
| NO (1) | NO20041411L (hu) |
| NZ (1) | NZ531591A (hu) |
| OA (1) | OA12664A (hu) |
| PA (1) | PA8556101A1 (hu) |
| PE (1) | PE20030478A1 (hu) |
| PL (1) | PL369454A1 (hu) |
| SK (1) | SK1642004A3 (hu) |
| TN (1) | TNSN04057A1 (hu) |
| UY (1) | UY27476A1 (hu) |
| WO (1) | WO2003030993A1 (hu) |
| ZA (1) | ZA200401747B (hu) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030232739A1 (en) * | 2001-08-15 | 2003-12-18 | Pfizer Inc. | Pharmaceutical combinations comprising a NOS inhibitor and an NMDA receptor antagonist |
| JP2008545616A (ja) * | 2005-02-21 | 2008-12-18 | プロキシマジェン エルティーディー | ジスキネジーの阻害または治療 |
| AU2011347718B2 (en) * | 2010-12-24 | 2016-06-23 | Msd Oss B.V. | N-substituted azetidine derivatives |
| RU2637503C1 (ru) * | 2016-12-30 | 2017-12-05 | Федеральное государственное автономное образовательное учреждение высшего образования "Национальный исследовательский Томский государственный университет" (ТГУ, НИ ТГУ) | Способ получения n2-метилдезоксигуанозина |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997036871A1 (en) * | 1996-03-29 | 1997-10-09 | Pfizer Inc. | 6-phenylpyridyl-2-amine derivatives |
| UA64740C2 (uk) * | 1997-02-10 | 2004-03-15 | Пфайзер Продактс Інк. | Похідні 2-амінопіридинів, фармацевтична композиція на їх основі (варіанти), спосіб лікування (варіанти), спосіб інгібування nos у ссавця та проміжні сполуки (варіанти) |
| KR20020010916A (ko) * | 1999-05-21 | 2002-02-06 | 실버스타인 아써 에이. | Ｎｏｓ 억제제로서의 신규한 약학 혼합물 |
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2002
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- 2002-09-24 HU HU0401678A patent/HUP0401678A3/hu unknown
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- 2002-09-24 EP EP02775016A patent/EP1434624B1/en not_active Expired - Lifetime
- 2002-09-24 CN CNA028200675A patent/CN1568207A/zh active Pending
- 2002-09-24 CA CA002463364A patent/CA2463364A1/en not_active Abandoned
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- 2004-04-02 NO NO20041411A patent/NO20041411L/no unknown
- 2004-04-06 BG BG108669A patent/BG108669A/xx unknown
- 2004-04-07 TN TNP2004000057A patent/TNSN04057A1/fr unknown
- 2004-04-08 MA MA27619A patent/MA27074A1/fr unknown
- 2004-04-08 EC EC2004005055A patent/ECSP045055A/es unknown
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| FD9A | Lapse of provisional protection due to non-payment of fees |