HU213394B - Process for producing pharmaceutical compositions containing cyclosporins as active components - Google Patents

Process for producing pharmaceutical compositions containing cyclosporins as active components Download PDF

Info

Publication number: HU213394B
Authority: HU; Hungary
Prior art keywords: component; cyclosporin; priority; solid; weight ratio
Prior art date: 1989-02-09

Application number

HU90701A

Other languages

English (en)

Hungarian (hu)

Other versions

HU900701D0 (en

Inventor

Birgit Hauer

Ulrich Posanski

Original Assignee

Sandoz Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-02-09

Filing date

1990-02-07

Publication date

1997-06-30

1989-02-09 Priority claimed from GB898902898A external-priority patent/GB8902898D0/en

1989-02-09 Priority claimed from GB898902901A external-priority patent/GB8902901D0/en

1989-02-13 Priority claimed from GB898903147A external-priority patent/GB8903147D0/en

1989-02-17 Priority claimed from GB898903663A external-priority patent/GB8903663D0/en

1990-02-07 Application filed by Sandoz Ag filed Critical Sandoz Ag

1990-04-28 Publication of HU900701D0 publication Critical patent/HU900701D0/hu

1997-06-30 Publication of HU213394B publication Critical patent/HU213394B/hu

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/485—Inorganic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Immunology (AREA)
Epidemiology (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Physical Education & Sports Medicine (AREA)
Orthopedic Medicine & Surgery (AREA)
Rheumatology (AREA)
Gastroenterology & Hepatology (AREA)
Oil, Petroleum & Natural Gas (AREA)
Pain & Pain Management (AREA)
Dermatology (AREA)
Biochemistry (AREA)
Tropical Medicine & Parasitology (AREA)
Diabetes (AREA)
Inorganic Chemistry (AREA)
Transplantation (AREA)
Hematology (AREA)
Neurology (AREA)
Biophysics (AREA)
Medicinal Preparation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

HU90701A 1989-02-09 1990-02-07 Process for producing pharmaceutical compositions containing cyclosporins as active components HU213394B (en)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
GB898902898A GB8902898D0 (en)	1989-02-09	1989-02-09	Improvements in or relating to organic compounds
GB898902901A GB8902901D0 (en)	1989-02-09	1989-02-09	Improvements in or relating to organic compounds
GB898903147A GB8903147D0 (en)	1989-02-13	1989-02-13	Improvements in or relating to organic compounds
GB898903663A GB8903663D0 (en)	1989-02-17	1989-02-17	Improvements in or relating to organic compounds

Publications (2)

Publication Number	Publication Date
HU900701D0 HU900701D0 (en)	1990-04-28
HU213394B true HU213394B (en)	1997-06-30

Family

ID=27450262

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HU90701A HU213394B (en)	1989-02-09	1990-02-07	Process for producing pharmaceutical compositions containing cyclosporins as active components

Country Status (25)

Country	Link
JP (3)	JP3484190B2 (fr)
KR (1)	KR0170769B1 (fr)
AT (1)	AT404552B (fr)
AU (1)	AU630413B2 (fr)
BE (1)	BE1003009A5 (fr)
CA (1)	CA2009533C (fr)
CH (1)	CH679277A5 (fr)
CY (1)	CY1903A (fr)
DE (1)	DE4003844B4 (fr)
DK (1)	DK176209B1 (fr)
ES (1)	ES2021942A6 (fr)
FI (1)	FI97524C (fr)
FR (1)	FR2642650B1 (fr)
GB (1)	GB2230440B (fr)
HK (1)	HK37296A (fr)
HU (1)	HU213394B (fr)
IT (1)	IT1240758B (fr)
LU (1)	LU87675A1 (fr)
MY (1)	MY107377A (fr)
NL (1)	NL195028C (fr)
NO (1)	NO301576B1 (fr)
NZ (1)	NZ232401A (fr)
PH (1)	PH30917A (fr)
PT (1)	PT93079B (fr)
SE (1)	SE511398C2 (fr)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR0148748B1 (ko) *	1988-09-16	1998-08-17	장 크라메르, 한스 루돌프 하우스	사이클로스포린을 함유하는 약학조성물
HU208491B (en) *	1990-11-27	1993-11-29	Gyogyszerkutato Intezet	Process for producing oral pharmaceutical composition containing cyclosporin
MX9201782A (es) †	1991-04-19	1992-10-01	Sandoz Ag	Particulas de sustancias biologicamente activas, sustancialmente insolubles en agua, proceso para su produccion y composicion farmaceutica que las contiene.
GB9113872D0 (en) *	1991-06-27	1991-08-14	Sandoz Ag	Improvements in or relating to organic compounds
US6262022B1 (en)	1992-06-25	2001-07-17	Novartis Ag	Pharmaceutical compositions containing cyclosporin as the active agent
EP0642332B1 (fr)	1992-05-13	1997-01-15	Sandoz Ltd.	Compositions ophtalmiques contenant une cyclosporine
US5759566A (en) *	1992-07-28	1998-06-02	Poli Industria Chimica Spa	Microemulsion pharmaceutical compositions for the delivery of pharmaceutically active agents
EP1142568A1 (fr)	1992-09-25	2001-10-10	Novartis AG	Compositions pharmaceutiques à base de cyclosporines
SK283442B6 (sk) †	1993-04-20	2003-07-01	Novartis Ag	Farmaceutický prípravok na orálne podanie
DE4412201A1 (de) *	1993-04-20	1994-11-10	Rentschler Arzneimittel	Neue pharmazeutische Zubereitungen zur oralen Verabreichung enthaltend Cyclosporin
DE4340781C3 (de) *	1993-11-30	2000-01-27	Novartis Ag	Cyclosporin enthaltende flüssige Zubereitungen und Verfahren zu ihrer Herstellung
KR0146671B1 (ko) *	1994-02-25	1998-08-17	김충환	사이클로스포린-함유 분말 조성물
RU2158601C2 (ru)	1994-11-03	2000-11-10	Новартис Аг	Новые лекарственные формы циклоспорина для орального применения с простым составом и высокой биодоступностью и способ их получения
US5679566A (en) *	1995-01-20	1997-10-21	University Of Massachusetts Medical Center	Yeast NMD2 gene
US5766629A (en) *	1995-08-25	1998-06-16	Sangstat Medical Corporation	Oral cyclosporin formulations
US5827822A (en) *	1996-03-25	1998-10-27	Sangstat Medical Corporation	Cyclosporin a formulations as nanoparticles
US5962019A (en) *	1995-08-25	1999-10-05	Sangstat Medical Corporation	Oral cyclosporin formulations
US5834017A (en) *	1995-08-25	1998-11-10	Sangstat Medical Corporation	Oral cyclopsporin formulations
DE19549852B4 (de)	1995-11-29	2009-06-04	Novartis Ag	Cyclosporin enthaltende Präparate
US5798333A (en) *	1996-09-17	1998-08-25	Sherman; Bernard C.	Water-soluble concentrates containing cyclosporins
BR9807528A (pt)	1997-01-30	2000-03-14	Novartis Ag	Composições farmacêuticas isentas de óleo contendo ciclosporina a
AU762247B2 (en) *	1997-01-30	2003-06-19	Novartis Ag	Oil-free pharmaceutical compositions containing cyclosporin A
SI0969856T1 (en) *	1997-03-12	2005-06-30	Abbott Laboratories	Hydrophilic binary systems for the administration of cyclosporine
NZ328751A (en) *	1997-09-16	1999-01-28	Bernard Charles Sherman	Solid medicament containing an anionic surfactant and cyclosporin
US6447806B1 (en)	1999-02-25	2002-09-10	Novartis Ag	Pharmaceutical compositions comprised of stabilized peptide particles
US6979672B2 (en)	2002-12-20	2005-12-27	Polichem, S.A.	Cyclosporin-based pharmaceutical compositions
JP4521554B2 (ja) *	2004-03-31	2010-08-11	マイラン製薬株式会社	シクロスポリン製剤
CN101360485B (zh) *	2005-10-26	2013-04-17	班纳制药公司	作为胶囊填充物的基于亲水性载体的双重控释基质系统
EP2004203A4 (fr) *	2006-03-28	2010-03-31	Javelin Pharmaceuticals Inc	Formulations de diclofénac et de cyclodextrine bêta à faible dosage
US7495024B2 (en)	2006-08-07	2009-02-24	Via Pharmaceuticals, Inc.	Phenylalkyl N-hydroxyureas for combating atherosclerotic plaque
DE102008059201A1 (de) *	2008-11-27	2010-06-02	GÖPFERICH, Achim, Prof. Dr.	In situ präzipitierende Arzneistofflösungen
KR102146704B1 (ko)	2018-04-13	2020-08-21	가천대학교 산학협력단	사이클로스포린 A (CsA) 경피 및 피내 약물전달용 마이크로구조체
WO2023063376A1 (fr) *	2021-10-13	2023-04-20	中外製薬株式会社	Composition comprenant un composé peptidique et un tensioactif

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FI65914C (fi) *	1978-03-07	1984-08-10	Sandoz Ag	Foerfarande foer framstaellning av farmaceutiska kompositionerinnehaollande cyklosporin a
JPS61280435A (ja) *	1985-04-04	1986-12-11	Kanji Takada	サイクロスポリン類のリンパ指向性製剤
NL8600050A (nl) *	1986-01-13	1987-08-03	Sanico Nv	Farmaceutisch preparaat met vertraagde afgifte van het werkzame bestanddeel en werkwijze voor de bereiding er van.
GB8602372D0 (en) *	1986-01-31	1986-03-05	Sandoz Ltd	Organic compounds
CA1290249C (fr) *	1986-04-09	1991-10-08	Cetus Corporation	TRAITEMENT A BASE D'INTERLEUKINE-2 ET (OU) D'INTERFERON .beta. ET FACTEUR DE NECROSE TUMORALE
AU617295B2 (en) *	1986-11-13	1991-11-28	Sloan-Kettering Institute For Cancer Research	Compositions and method for treatment of cancer using monoclonal antibody against gd3 ganglioside together with il-2
ATE95193T1 (de) *	1987-06-17	1993-10-15	Sandoz Ag	Cyclosporine und deren benutzung als arzneimittel.
JP2536876B2 (ja) *	1987-07-31	1996-09-25	寛治高田	シクロスポリンの溶解性粉末状製剤
US5756450A (en) *	1987-09-15	1998-05-26	Novartis Corporation	Water soluble monoesters as solubilisers for pharmacologically active compounds and pharmaceutical excipients and novel cyclosporin galenic forms
DE3830494B4 (de) *	1987-09-15	2006-05-18	Novartis Ag	Wasserlösliche Monoester als Solubilisatoren für pharmakologische Wirkstoffe und pharmazeutische Hilfsstoffe
HU205010B (en) *	1987-09-15	1992-03-30	Sandoz Ag	Process for producing pharmaceutical compositions comprising compounds soluble up to 1 per cent and having medical activity
JP2792862B2 (ja) *	1988-07-30	1998-09-03	寛治高田	経口腸溶製剤
KR0148748B1 (ko) *	1988-09-16	1998-08-17	장 크라메르, 한스 루돌프 하우스	사이클로스포린을 함유하는 약학조성물
JPH1038029A (ja) *	1996-07-26	1998-02-13	Ebara Corp	制振機能付き円板状構造物
JPH10280435A (ja) *	1997-04-03	1998-10-20	Sekisui Chem Co Ltd	地下室の構築方法

1990
- 1990-02-05 BE BE9000133A patent/BE1003009A5/fr not_active IP Right Cessation
- 1990-02-05 CH CH359/90A patent/CH679277A5/de not_active IP Right Cessation
- 1990-02-05 FR FR9001389A patent/FR2642650B1/fr not_active Expired - Lifetime
- 1990-02-05 GB GB9002504A patent/GB2230440B/en not_active Expired - Lifetime
- 1990-02-07 LU LU87675A patent/LU87675A1/fr unknown
- 1990-02-07 FI FI900604A patent/FI97524C/fi active IP Right Grant
- 1990-02-07 NO NO900577A patent/NO301576B1/no not_active IP Right Cessation
- 1990-02-07 SE SE9000441A patent/SE511398C2/sv not_active Application Discontinuation
- 1990-02-07 NZ NZ232401A patent/NZ232401A/en unknown
- 1990-02-07 HU HU90701A patent/HU213394B/hu unknown
- 1990-02-07 MY MYPI90000191A patent/MY107377A/en unknown
- 1990-02-07 PT PT93079A patent/PT93079B/pt not_active IP Right Cessation
- 1990-02-07 PH PH40014A patent/PH30917A/en unknown
- 1990-02-07 CA CA002009533A patent/CA2009533C/fr not_active Expired - Lifetime
- 1990-02-07 DK DK199000327A patent/DK176209B1/da not_active IP Right Cessation
- 1990-02-08 AT AT0027290A patent/AT404552B/de not_active IP Right Cessation
- 1990-02-08 KR KR1019900001492A patent/KR0170769B1/ko not_active IP Right Cessation
- 1990-02-08 IT IT47609A patent/IT1240758B/it active IP Right Grant
- 1990-02-08 NL NL9000299A patent/NL195028C/nl not_active IP Right Cessation
- 1990-02-08 AU AU49252/90A patent/AU630413B2/en not_active Expired
- 1990-02-08 DE DE4003844A patent/DE4003844B4/de not_active Expired - Lifetime
- 1990-02-08 JP JP03134890A patent/JP3484190B2/ja not_active Expired - Lifetime
- 1990-02-09 ES ES9000397A patent/ES2021942A6/es not_active Expired - Lifetime
1996
- 1996-03-07 HK HK37296A patent/HK37296A/xx not_active IP Right Cessation
- 1996-11-22 CY CY190396A patent/CY1903A/xx unknown
2001
- 2001-04-25 JP JP2001127538A patent/JP4073641B2/ja not_active Expired - Lifetime
2005
- 2005-09-13 JP JP2005265724A patent/JP2006001947A/ja active Pending

Also Published As

Publication number	Publication date
JP4073641B2 (ja)	2008-04-09
PH30917A (en)	1997-12-23
FR2642650A1 (fr)	1990-08-10
DK32790A (da)	1990-08-10
FI97524C (fi)	1997-01-10
CH679277A5 (fr)	1992-01-31
GB2230440B (en)	1993-05-19
JPH02235817A (ja)	1990-09-18
FR2642650B1 (fr)	1994-12-09
FI900604A0 (fi)	1990-02-07
JP2006001947A (ja)	2006-01-05
IT9047609A1 (it)	1991-08-08
SE9000441L (sv)	1991-08-08
GB2230440A (en)	1990-10-24
AU4925290A (en)	1990-08-16
DK32790D0 (da)	1990-02-07
JP3484190B2 (ja)	2004-01-06
CY1903A (en)	1996-11-22
SE511398C2 (sv)	1999-09-20
AU630413B2 (en)	1992-10-29
NL195028C (nl)	2003-12-02
SE9000441D0 (sv)	1990-02-07
NO900577D0 (no)	1990-02-07
CA2009533C (fr)	2002-11-12
NO301576B1 (no)	1997-11-17
IT9047609A0 (it)	1990-02-08
GB9002504D0 (en)	1990-04-04
DK176209B1 (da)	2007-02-05
NL9000299A (nl)	1990-09-03
NZ232401A (en)	1992-10-28
AT404552B (de)	1998-12-28
LU87675A1 (fr)	1991-10-08
HK37296A (en)	1996-03-15
KR900012625A (ko)	1990-09-01
BE1003009A5 (fr)	1991-10-22
FI97524B (fi)	1996-09-30
JP2001302538A (ja)	2001-10-31
ES2021942A6 (es)	1991-11-16
IT1240758B (it)	1993-12-17
HU900701D0 (en)	1990-04-28
NO900577L (no)	1990-08-10
NL195028B (nl)	2003-08-01
CA2009533A1 (fr)	1990-08-09
MY107377A (en)	1995-11-30
DE4003844B4 (de)	2007-09-20
PT93079B (pt)	1996-04-30
ATA27290A (de)	1998-05-15
PT93079A (pt)	1990-08-31
DE4003844A1 (de)	1990-08-16
KR0170769B1 (ko)	1999-02-01

Publication	Publication Date	Title
HU213394B (en)	1997-06-30	Process for producing pharmaceutical compositions containing cyclosporins as active components
US5756450A (en)	1998-05-26	Water soluble monoesters as solubilisers for pharmacologically active compounds and pharmaceutical excipients and novel cyclosporin galenic forms
KR100446170B1 (ko)	2004-11-20	사이클로스포린을함유하는약학조성물
US6197335B1 (en)	2001-03-06	Solid pharmaceutical compositions comprising a cyclosporin and an anionic surfactant
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Date	Code	Title	Description
1997-11-28	HPC4	Succession in title of patentee	Owner name: NOVARTIS AG, CH