CA2009533A1 - Formes posologiques de cyclosporine - Google Patents

Formes posologiques de cyclosporine

Info

Publication number: CA2009533A1
Authority: CA; Canada
Prior art keywords: alkylene; galenic forms; glycol; ethanol; novel cyclosporin
Prior art date: 1989-02-09
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

CA002009533A

Other languages

English (en)

Other versions

CA2009533C (fr

Inventor

Birgit Hauer

Ulrich Posanski

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Novartis AG

Original Assignee

Individual

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-02-09

Filing date

1990-02-07

Publication date

1990-08-09

1989-02-09 Priority claimed from GB898902898A external-priority patent/GB8902898D0/en

1989-02-09 Priority claimed from GB898902901A external-priority patent/GB8902901D0/en

1989-02-13 Priority claimed from GB898903147A external-priority patent/GB8903147D0/en

1989-02-17 Priority claimed from GB898903663A external-priority patent/GB8903663D0/en

1990-02-07 Application filed by Individual filed Critical Individual

1990-08-09 Publication of CA2009533A1 publication Critical patent/CA2009533A1/fr

2002-11-12 Application granted granted Critical

2002-11-12 Publication of CA2009533C publication Critical patent/CA2009533C/fr

2010-02-07 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/485—Inorganic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Immunology (AREA)
Epidemiology (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Physical Education & Sports Medicine (AREA)
Orthopedic Medicine & Surgery (AREA)
Rheumatology (AREA)
Gastroenterology & Hepatology (AREA)
Oil, Petroleum & Natural Gas (AREA)
Pain & Pain Management (AREA)
Dermatology (AREA)
Biochemistry (AREA)
Tropical Medicine & Parasitology (AREA)
Diabetes (AREA)
Inorganic Chemistry (AREA)
Transplantation (AREA)
Hematology (AREA)
Neurology (AREA)
Biophysics (AREA)
Medicinal Preparation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

CA002009533A 1989-02-09 1990-02-07 Formes posologiques de cyclosporine Expired - Lifetime CA2009533C (fr)

Applications Claiming Priority (8)

Application Number	Priority Date	Filing Date	Title
GB898902898A GB8902898D0 (en)	1989-02-09	1989-02-09	Improvements in or relating to organic compounds
GB898902901A GB8902901D0 (en)	1989-02-09	1989-02-09	Improvements in or relating to organic compounds
GB8902901		1989-02-09
GB8902898		1989-02-09
GB8903147		1989-02-13
GB898903147A GB8903147D0 (en)	1989-02-13	1989-02-13	Improvements in or relating to organic compounds
GB898903663A GB8903663D0 (en)	1989-02-17	1989-02-17	Improvements in or relating to organic compounds
GB8903663		1989-02-17

Publications (2)

Publication Number	Publication Date
CA2009533A1 true CA2009533A1 (fr)	1990-08-09
CA2009533C CA2009533C (fr)	2002-11-12

Family

ID=27450262

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA002009533A Expired - Lifetime CA2009533C (fr)	1989-02-09	1990-02-07	Formes posologiques de cyclosporine

Country Status (25)

Country	Link
JP (3)	JP3484190B2 (fr)
KR (1)	KR0170769B1 (fr)
AT (1)	AT404552B (fr)
AU (1)	AU630413B2 (fr)
BE (1)	BE1003009A5 (fr)
CA (1)	CA2009533C (fr)
CH (1)	CH679277A5 (fr)
CY (1)	CY1903A (fr)
DE (1)	DE4003844B4 (fr)
DK (1)	DK176209B1 (fr)
ES (1)	ES2021942A6 (fr)
FI (1)	FI97524C (fr)
FR (1)	FR2642650B1 (fr)
GB (1)	GB2230440B (fr)
HK (1)	HK37296A (fr)
HU (1)	HU213394B (fr)
IT (1)	IT1240758B (fr)
LU (1)	LU87675A1 (fr)
MY (1)	MY107377A (fr)
NL (1)	NL195028C (fr)
NO (1)	NO301576B1 (fr)
NZ (1)	NZ232401A (fr)
PH (1)	PH30917A (fr)
PT (1)	PT93079B (fr)
SE (1)	SE511398C2 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5766629A (en) *	1995-08-25	1998-06-16	Sangstat Medical Corporation	Oral cyclosporin formulations
US5827822A (en) *	1996-03-25	1998-10-27	Sangstat Medical Corporation	Cyclosporin a formulations as nanoparticles
US5834017A (en) *	1995-08-25	1998-11-10	Sangstat Medical Corporation	Oral cyclopsporin formulations
US5962019A (en) *	1995-08-25	1999-10-05	Sangstat Medical Corporation	Oral cyclosporin formulations

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR0148748B1 (ko) *	1988-09-16	1998-08-17	장 크라메르, 한스 루돌프 하우스	사이클로스포린을 함유하는 약학조성물
HU208491B (en) *	1990-11-27	1993-11-29	Gyogyszerkutato Intezet	Process for producing oral pharmaceutical composition containing cyclosporin
MX9201782A (es) †	1991-04-19	1992-10-01	Sandoz Ag	Particulas de sustancias biologicamente activas, sustancialmente insolubles en agua, proceso para su produccion y composicion farmaceutica que las contiene.
GB9113872D0 (en) *	1991-06-27	1991-08-14	Sandoz Ag	Improvements in or relating to organic compounds
US6262022B1 (en)	1992-06-25	2001-07-17	Novartis Ag	Pharmaceutical compositions containing cyclosporin as the active agent
EP0642332B1 (fr)	1992-05-13	1997-01-15	Sandoz Ltd.	Compositions ophtalmiques contenant une cyclosporine
US5759566A (en) *	1992-07-28	1998-06-02	Poli Industria Chimica Spa	Microemulsion pharmaceutical compositions for the delivery of pharmaceutically active agents
EP1142568A1 (fr)	1992-09-25	2001-10-10	Novartis AG	Compositions pharmaceutiques à base de cyclosporines
SK283442B6 (sk) †	1993-04-20	2003-07-01	Novartis Ag	Farmaceutický prípravok na orálne podanie
DE4412201A1 (de) *	1993-04-20	1994-11-10	Rentschler Arzneimittel	Neue pharmazeutische Zubereitungen zur oralen Verabreichung enthaltend Cyclosporin
DE4340781C3 (de) *	1993-11-30	2000-01-27	Novartis Ag	Cyclosporin enthaltende flüssige Zubereitungen und Verfahren zu ihrer Herstellung
KR0146671B1 (ko) *	1994-02-25	1998-08-17	김충환	사이클로스포린-함유 분말 조성물
RU2158601C2 (ru)	1994-11-03	2000-11-10	Новартис Аг	Новые лекарственные формы циклоспорина для орального применения с простым составом и высокой биодоступностью и способ их получения
US5679566A (en) *	1995-01-20	1997-10-21	University Of Massachusetts Medical Center	Yeast NMD2 gene
DE19549852B4 (de)	1995-11-29	2009-06-04	Novartis Ag	Cyclosporin enthaltende Präparate
US5798333A (en) *	1996-09-17	1998-08-25	Sherman; Bernard C.	Water-soluble concentrates containing cyclosporins
BR9807528A (pt)	1997-01-30	2000-03-14	Novartis Ag	Composições farmacêuticas isentas de óleo contendo ciclosporina a
AU762247B2 (en) *	1997-01-30	2003-06-19	Novartis Ag	Oil-free pharmaceutical compositions containing cyclosporin A
SI0969856T1 (en) *	1997-03-12	2005-06-30	Abbott Laboratories	Hydrophilic binary systems for the administration of cyclosporine
NZ328751A (en) *	1997-09-16	1999-01-28	Bernard Charles Sherman	Solid medicament containing an anionic surfactant and cyclosporin
US6447806B1 (en)	1999-02-25	2002-09-10	Novartis Ag	Pharmaceutical compositions comprised of stabilized peptide particles
US6979672B2 (en)	2002-12-20	2005-12-27	Polichem, S.A.	Cyclosporin-based pharmaceutical compositions
JP4521554B2 (ja) *	2004-03-31	2010-08-11	マイラン製薬株式会社	シクロスポリン製剤
CN101360485B (zh) *	2005-10-26	2013-04-17	班纳制药公司	作为胶囊填充物的基于亲水性载体的双重控释基质系统
EP2004203A4 (fr) *	2006-03-28	2010-03-31	Javelin Pharmaceuticals Inc	Formulations de diclofénac et de cyclodextrine bêta à faible dosage
US7495024B2 (en)	2006-08-07	2009-02-24	Via Pharmaceuticals, Inc.	Phenylalkyl N-hydroxyureas for combating atherosclerotic plaque
DE102008059201A1 (de) *	2008-11-27	2010-06-02	GÖPFERICH, Achim, Prof. Dr.	In situ präzipitierende Arzneistofflösungen
KR102146704B1 (ko)	2018-04-13	2020-08-21	가천대학교 산학협력단	사이클로스포린 A (CsA) 경피 및 피내 약물전달용 마이크로구조체
WO2023063376A1 (fr) *	2021-10-13	2023-04-20	中外製薬株式会社	Composition comprenant un composé peptidique et un tensioactif

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FI65914C (fi) *	1978-03-07	1984-08-10	Sandoz Ag	Foerfarande foer framstaellning av farmaceutiska kompositionerinnehaollande cyklosporin a
JPS61280435A (ja) *	1985-04-04	1986-12-11	Kanji Takada	サイクロスポリン類のリンパ指向性製剤
NL8600050A (nl) *	1986-01-13	1987-08-03	Sanico Nv	Farmaceutisch preparaat met vertraagde afgifte van het werkzame bestanddeel en werkwijze voor de bereiding er van.
GB8602372D0 (en) *	1986-01-31	1986-03-05	Sandoz Ltd	Organic compounds
CA1290249C (fr) *	1986-04-09	1991-10-08	Cetus Corporation	TRAITEMENT A BASE D'INTERLEUKINE-2 ET (OU) D'INTERFERON .beta. ET FACTEUR DE NECROSE TUMORALE
AU617295B2 (en) *	1986-11-13	1991-11-28	Sloan-Kettering Institute For Cancer Research	Compositions and method for treatment of cancer using monoclonal antibody against gd3 ganglioside together with il-2
ATE95193T1 (de) *	1987-06-17	1993-10-15	Sandoz Ag	Cyclosporine und deren benutzung als arzneimittel.
JP2536876B2 (ja) *	1987-07-31	1996-09-25	寛治高田	シクロスポリンの溶解性粉末状製剤
US5756450A (en) *	1987-09-15	1998-05-26	Novartis Corporation	Water soluble monoesters as solubilisers for pharmacologically active compounds and pharmaceutical excipients and novel cyclosporin galenic forms
DE3830494B4 (de) *	1987-09-15	2006-05-18	Novartis Ag	Wasserlösliche Monoester als Solubilisatoren für pharmakologische Wirkstoffe und pharmazeutische Hilfsstoffe
HU205010B (en) *	1987-09-15	1992-03-30	Sandoz Ag	Process for producing pharmaceutical compositions comprising compounds soluble up to 1 per cent and having medical activity
JP2792862B2 (ja) *	1988-07-30	1998-09-03	寛治高田	経口腸溶製剤
KR0148748B1 (ko) *	1988-09-16	1998-08-17	장 크라메르, 한스 루돌프 하우스	사이클로스포린을 함유하는 약학조성물
JPH1038029A (ja) *	1996-07-26	1998-02-13	Ebara Corp	制振機能付き円板状構造物
JPH10280435A (ja) *	1997-04-03	1998-10-20	Sekisui Chem Co Ltd	地下室の構築方法

1990
- 1990-02-05 BE BE9000133A patent/BE1003009A5/fr not_active IP Right Cessation
- 1990-02-05 CH CH359/90A patent/CH679277A5/de not_active IP Right Cessation
- 1990-02-05 FR FR9001389A patent/FR2642650B1/fr not_active Expired - Lifetime
- 1990-02-05 GB GB9002504A patent/GB2230440B/en not_active Expired - Lifetime
- 1990-02-07 LU LU87675A patent/LU87675A1/fr unknown
- 1990-02-07 FI FI900604A patent/FI97524C/fi active IP Right Grant
- 1990-02-07 NO NO900577A patent/NO301576B1/no not_active IP Right Cessation
- 1990-02-07 SE SE9000441A patent/SE511398C2/sv not_active Application Discontinuation
- 1990-02-07 NZ NZ232401A patent/NZ232401A/en unknown
- 1990-02-07 HU HU90701A patent/HU213394B/hu unknown
- 1990-02-07 MY MYPI90000191A patent/MY107377A/en unknown
- 1990-02-07 PT PT93079A patent/PT93079B/pt not_active IP Right Cessation
- 1990-02-07 PH PH40014A patent/PH30917A/en unknown
- 1990-02-07 CA CA002009533A patent/CA2009533C/fr not_active Expired - Lifetime
- 1990-02-07 DK DK199000327A patent/DK176209B1/da not_active IP Right Cessation
- 1990-02-08 AT AT0027290A patent/AT404552B/de not_active IP Right Cessation
- 1990-02-08 KR KR1019900001492A patent/KR0170769B1/ko not_active IP Right Cessation
- 1990-02-08 IT IT47609A patent/IT1240758B/it active IP Right Grant
- 1990-02-08 NL NL9000299A patent/NL195028C/nl not_active IP Right Cessation
- 1990-02-08 AU AU49252/90A patent/AU630413B2/en not_active Expired
- 1990-02-08 DE DE4003844A patent/DE4003844B4/de not_active Expired - Lifetime
- 1990-02-08 JP JP03134890A patent/JP3484190B2/ja not_active Expired - Lifetime
- 1990-02-09 ES ES9000397A patent/ES2021942A6/es not_active Expired - Lifetime
1996
- 1996-03-07 HK HK37296A patent/HK37296A/xx not_active IP Right Cessation
- 1996-11-22 CY CY190396A patent/CY1903A/xx unknown
2001
- 2001-04-25 JP JP2001127538A patent/JP4073641B2/ja not_active Expired - Lifetime
2005
- 2005-09-13 JP JP2005265724A patent/JP2006001947A/ja active Pending

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5766629A (en) *	1995-08-25	1998-06-16	Sangstat Medical Corporation	Oral cyclosporin formulations
US5834017A (en) *	1995-08-25	1998-11-10	Sangstat Medical Corporation	Oral cyclopsporin formulations
US5962019A (en) *	1995-08-25	1999-10-05	Sangstat Medical Corporation	Oral cyclosporin formulations
US6254885B1 (en)	1995-08-25	2001-07-03	Sangstat Medical Corporation	Oral cyclosphorin formulations
US5827822A (en) *	1996-03-25	1998-10-27	Sangstat Medical Corporation	Cyclosporin a formulations as nanoparticles

Also Published As

Publication number	Publication date
JP4073641B2 (ja)	2008-04-09
PH30917A (en)	1997-12-23
FR2642650A1 (fr)	1990-08-10
DK32790A (da)	1990-08-10
FI97524C (fi)	1997-01-10
CH679277A5 (fr)	1992-01-31
GB2230440B (en)	1993-05-19
JPH02235817A (ja)	1990-09-18
FR2642650B1 (fr)	1994-12-09
FI900604A0 (fi)	1990-02-07
JP2006001947A (ja)	2006-01-05
IT9047609A1 (it)	1991-08-08
SE9000441L (sv)	1991-08-08
HU213394B (en)	1997-06-30
GB2230440A (en)	1990-10-24
AU4925290A (en)	1990-08-16
DK32790D0 (da)	1990-02-07
JP3484190B2 (ja)	2004-01-06
CY1903A (en)	1996-11-22
SE511398C2 (sv)	1999-09-20
AU630413B2 (en)	1992-10-29
NL195028C (nl)	2003-12-02
SE9000441D0 (sv)	1990-02-07
NO900577D0 (no)	1990-02-07
CA2009533C (fr)	2002-11-12
NO301576B1 (no)	1997-11-17
IT9047609A0 (it)	1990-02-08
GB9002504D0 (en)	1990-04-04
DK176209B1 (da)	2007-02-05
NL9000299A (nl)	1990-09-03
NZ232401A (en)	1992-10-28
AT404552B (de)	1998-12-28
LU87675A1 (fr)	1991-10-08
HK37296A (en)	1996-03-15
KR900012625A (ko)	1990-09-01
BE1003009A5 (fr)	1991-10-22
FI97524B (fi)	1996-09-30
JP2001302538A (ja)	2001-10-31
ES2021942A6 (es)	1991-11-16
IT1240758B (it)	1993-12-17
HU900701D0 (en)	1990-04-28
NO900577L (no)	1990-08-10
NL195028B (nl)	2003-08-01
MY107377A (en)	1995-11-30
DE4003844B4 (de)	2007-09-20
PT93079B (pt)	1996-04-30
ATA27290A (de)	1998-05-15
PT93079A (pt)	1990-08-31
DE4003844A1 (de)	1990-08-16
KR0170769B1 (ko)	1999-02-01

Publication	Publication Date	Title
CA2009533A1 (fr)	1990-08-09	Formes posologiques de cyclosporine
CA2004598A1 (fr)	1990-06-06	Aerosols medicinaux
CA2039518A1 (fr)	1991-10-05	Gel cosmetique en baton
MY107381A (en)	1995-11-30	Pharmaceutical compositions comprising cyclosporins.
AU7378787A (en)	1987-12-10	Controlled release pharmaceutical composition
FI945619A0 (fi)	1994-11-29	Syklosporiinia sisältävät nestemäiset valmisteet ja menetelmä niiden valmistamiseksi
IE790704L (en)	1979-09-07	Cyclosporin composition
HUP0004733A2 (hu)	2001-05-28	Ciklosporint tartalmazó orális készítmények
ES2186715T3 (es)	2003-05-16	Uso de un tensioactivo lipofilico en una composicion farmaceutica.
ES2158908T3 (es)	2001-09-16	Formulaciones en aerosol sin clorofluorocarbonos.
NL182731C (nl)	1988-05-02	Copolyetheresterpreparaat afgeleid van tereftaalzuur of een estervormend equivalent ervan, 1.4-butaandiol, een poly(propyleenoxide)glycol en een vertakkingsmiddel.
CA2141433A1 (fr)	1994-02-17	Nettoyant ininflammable et peu odorant pour solvants
IE893718L (en)	1990-05-22	Pharmaceutical Compositions
HUP9801052A2 (hu)	1998-09-28	Orális ciklosporin készítmények
FI954986A (fi)	1995-10-19	Uudet, suun kautta annettavat, syklosporiinia sisältävät farmaseuttiset valmisteet
GR3002420T3 (en)	1992-12-30	Medicinal formulation
GR1000466B (el)	1992-07-30	Μεθοδος παρασκευης νεων φαρμακευτικων μορφων κυκλοσπορινης.
IT1204778B (it)	1989-03-10	Formulazioni farmaceutiche iniettabili di principi attivi ad attivita' anestetica generale
IL93298A (en)	1997-06-10	Pharmaceutical compositions comprising cyclosporin

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