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HRP20090402T1 - N-sulfonilpiroli i njihova upotreba kao inhibitori histon-deacetilaze - Google Patents

N-sulfonilpiroli i njihova upotreba kao inhibitori histon-deacetilaze Download PDF

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Publication number
HRP20090402T1
HRP20090402T1 HR20090402T HRP20090402T HRP20090402T1 HR P20090402 T1 HRP20090402 T1 HR P20090402T1 HR 20090402 T HR20090402 T HR 20090402T HR P20090402 T HRP20090402 T HR P20090402T HR P20090402 T1 HRP20090402 T1 HR P20090402T1
Authority
HR
Croatia
Prior art keywords
pyrrol
phenyl
group
sulfonyl
acrylamide
Prior art date
Application number
HR20090402T
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English (en)
Croatian (hr)
Inventor
Maier Thomas
B�r Thomas
Beckers Thomas
Zimmermann Astrid
Schneider Siegfried
Gekeler Volker
Original Assignee
4Sc Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 4Sc Ag filed Critical 4Sc Ag
Publication of HRP20090402T1 publication Critical patent/HRP20090402T1/hr

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
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  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
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  • Virology (AREA)
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HR20090402T 2005-03-15 2009-07-15 N-sulfonilpiroli i njihova upotreba kao inhibitori histon-deacetilaze HRP20090402T1 (hr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP05102019 2005-03-15
EP05108735 2005-09-21
PCT/EP2006/060712 WO2006097474A1 (en) 2005-03-15 2006-03-14 N-sulphonylpyrroles and their use as histone deacetylase inhibitors

Publications (1)

Publication Number Publication Date
HRP20090402T1 true HRP20090402T1 (hr) 2009-08-31

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HR20090402T HRP20090402T1 (hr) 2005-03-15 2009-07-15 N-sulfonilpiroli i njihova upotreba kao inhibitori histon-deacetilaze

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US (2) US7666868B2 (el)
EP (1) EP1861365B1 (el)
JP (1) JP5119143B2 (el)
KR (1) KR101194510B1 (el)
CN (1) CN101137623B (el)
AT (1) ATE435203T1 (el)
AU (1) AU2006224553B2 (el)
BR (1) BRPI0608886B8 (el)
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CY (1) CY1109414T1 (el)
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EA (2) EA201100689A1 (el)
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HK (1) HK1125359A1 (el)
HR (1) HRP20090402T1 (el)
IL (1) IL185275A (el)
MX (1) MX2007010561A (el)
NO (1) NO340622B1 (el)
NZ (1) NZ560267A (el)
PL (1) PL1861365T3 (el)
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SI (1) SI1861365T1 (el)
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US20090208478A1 (en) * 2003-10-24 2009-08-20 Gencia Corporation Transducible polypeptides for modifying metabolism
US8062891B2 (en) 2003-10-24 2011-11-22 Gencia Corporation Nonviral vectors for delivering polynucleotides to plants
US20090123468A1 (en) 2003-10-24 2009-05-14 Gencia Corporation Transducible polypeptides for modifying metabolism
US8507277B2 (en) 2003-10-24 2013-08-13 Gencia Corporation Nonviral vectors for delivering polynucleotides
US8039587B2 (en) 2003-10-24 2011-10-18 Gencia Corporation Methods and compositions for delivering polynucleotides
US8133733B2 (en) 2003-10-24 2012-03-13 Gencia Corporation Nonviral vectors for delivering polynucleotides to target tissues
EP2272827A1 (en) * 2004-03-11 2011-01-12 4Sc Ag Sulphonylpyrroles as hdac inhibitors
US8741332B2 (en) 2004-06-07 2014-06-03 Nuvo Research Inc. Compositions and methods for dermally treating neuropathic pain
US8907153B2 (en) 2004-06-07 2014-12-09 Nuvo Research Inc. Adhesive peel-forming formulations for dermal delivery of drugs and methods of using the same
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