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NO20075051L - Nye sulfonylpyrroler og deres anvendelse som histon-deacetylaseinhibitorer - Google Patents

Nye sulfonylpyrroler og deres anvendelse som histon-deacetylaseinhibitorer

Info

Publication number
NO20075051L
NO20075051L NO20075051A NO20075051A NO20075051L NO 20075051 L NO20075051 L NO 20075051L NO 20075051 A NO20075051 A NO 20075051A NO 20075051 A NO20075051 A NO 20075051A NO 20075051 L NO20075051 L NO 20075051L
Authority
NO
Norway
Prior art keywords
pyrrols
histone deacetylase
deacetylase inhibitors
novel sulfonyl
novel
Prior art date
Application number
NO20075051A
Other languages
English (en)
Other versions
NO340622B1 (no
Inventor
Thomas Beckers
Thomas Maier
Thomas Bar
Astrid Zimmermann
Siegfried Schneider
Volker Gekeler
Original Assignee
Nycomed Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nycomed Gmbh filed Critical Nycomed Gmbh
Publication of NO20075051L publication Critical patent/NO20075051L/no
Publication of NO340622B1 publication Critical patent/NO340622B1/no

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • C07D207/48—Sulfur atoms
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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  • Health & Medical Sciences (AREA)
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Abstract

Forbindelser med en viss formel I, hvor RI, R2, R3, R4, R5, R6 og R7 har betydningene indikert i beskrivelsen, er nye effektive HDAC-inhibitorer.
NO20075051A 2005-03-15 2007-10-08 Nye sulfonylpyrroler og deres anvendelse som histon deacetylaseinhibitorer NO340622B1 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP05102019 2005-03-15
EP05108735 2005-09-21
PCT/EP2006/060712 WO2006097474A1 (en) 2005-03-15 2006-03-14 N-sulphonylpyrroles and their use as histone deacetylase inhibitors

Publications (2)

Publication Number Publication Date
NO20075051L true NO20075051L (no) 2007-10-08
NO340622B1 NO340622B1 (no) 2017-05-15

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NO20075051A NO340622B1 (no) 2005-03-15 2007-10-08 Nye sulfonylpyrroler og deres anvendelse som histon deacetylaseinhibitorer

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US (2) US7666868B2 (no)
EP (1) EP1861365B1 (no)
JP (1) JP5119143B2 (no)
KR (1) KR101194510B1 (no)
CN (1) CN101137623B (no)
AT (1) ATE435203T1 (no)
AU (1) AU2006224553B2 (no)
BR (1) BRPI0608886B8 (no)
CA (1) CA2599538C (no)
CY (1) CY1109414T1 (no)
DE (1) DE602006007558D1 (no)
DK (1) DK1861365T3 (no)
EA (2) EA201100689A1 (no)
ES (1) ES2327269T3 (no)
HK (1) HK1125359A1 (no)
HR (1) HRP20090402T1 (no)
IL (1) IL185275A (no)
MX (1) MX2007010561A (no)
NO (1) NO340622B1 (no)
NZ (1) NZ560267A (no)
PL (1) PL1861365T3 (no)
PT (1) PT1861365E (no)
RS (1) RS51151B (no)
SI (1) SI1861365T1 (no)
TW (1) TWI321562B (no)
WO (1) WO2006097474A1 (no)

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US20090208478A1 (en) * 2003-10-24 2009-08-20 Gencia Corporation Transducible polypeptides for modifying metabolism
US8062891B2 (en) 2003-10-24 2011-11-22 Gencia Corporation Nonviral vectors for delivering polynucleotides to plants
US20090123468A1 (en) 2003-10-24 2009-05-14 Gencia Corporation Transducible polypeptides for modifying metabolism
US8507277B2 (en) 2003-10-24 2013-08-13 Gencia Corporation Nonviral vectors for delivering polynucleotides
US8039587B2 (en) 2003-10-24 2011-10-18 Gencia Corporation Methods and compositions for delivering polynucleotides
US8133733B2 (en) 2003-10-24 2012-03-13 Gencia Corporation Nonviral vectors for delivering polynucleotides to target tissues
EP2272827A1 (en) * 2004-03-11 2011-01-12 4Sc Ag Sulphonylpyrroles as hdac inhibitors
US8741332B2 (en) 2004-06-07 2014-06-03 Nuvo Research Inc. Compositions and methods for dermally treating neuropathic pain
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