HK1099302A1 - Pyrazolo and imidazo-pyrimidine derivatives - Google Patents
Pyrazolo and imidazo-pyrimidine derivativesInfo
- Publication number
- HK1099302A1 HK1099302A1 HK07106520.9A HK07106520A HK1099302A1 HK 1099302 A1 HK1099302 A1 HK 1099302A1 HK 07106520 A HK07106520 A HK 07106520A HK 1099302 A1 HK1099302 A1 HK 1099302A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- pyrazolo
- imidazo
- pyrimidine derivatives
- pyrimidine
- derivatives
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Pain & Pain Management (AREA)
- Physical Education & Sports Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Endocrinology (AREA)
- Psychology (AREA)
- Virology (AREA)
- Oncology (AREA)
- Ophthalmology & Optometry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Heart & Thoracic Surgery (AREA)
- Communicable Diseases (AREA)
- Diabetes (AREA)
- AIDS & HIV (AREA)
- Reproductive Health (AREA)
- Cardiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Otolaryngology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP03078075 | 2003-10-03 | ||
PCT/EP2004/010807 WO2005040171A1 (en) | 2003-10-03 | 2004-09-27 | Pyrazolo and imidazo-pyrimidine derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1099302A1 true HK1099302A1 (en) | 2007-08-10 |
Family
ID=34486287
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK07106520.9A HK1099302A1 (en) | 2003-10-03 | 2007-06-18 | Pyrazolo and imidazo-pyrimidine derivatives |
Country Status (21)
Country | Link |
---|---|
US (2) | US7329662B2 (xx) |
EP (1) | EP1670801B1 (xx) |
JP (1) | JP4551402B2 (xx) |
KR (2) | KR20070096033A (xx) |
CN (2) | CN101239981B (xx) |
AR (1) | AR045959A1 (xx) |
AT (1) | ATE512148T1 (xx) |
AU (1) | AU2004283801B2 (xx) |
BR (1) | BRPI0414948A (xx) |
CA (1) | CA2540768C (xx) |
CO (1) | CO5680437A2 (xx) |
ES (1) | ES2364753T3 (xx) |
HK (1) | HK1099302A1 (xx) |
IL (1) | IL174512A0 (xx) |
MX (1) | MXPA06003526A (xx) |
NO (1) | NO20061363L (xx) |
NZ (1) | NZ546037A (xx) |
RU (1) | RU2350616C2 (xx) |
TW (1) | TWI297691B (xx) |
WO (1) | WO2005040171A1 (xx) |
ZA (1) | ZA200602677B (xx) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7329662B2 (en) * | 2003-10-03 | 2008-02-12 | Hoffmann-La Roche Inc. | Pyrazolo-pyridine |
BRPI0512330A (pt) * | 2004-06-21 | 2008-02-26 | Hoffmann La Roche | derivados de pirazol-pirimidina |
ATE512966T1 (de) | 2005-02-11 | 2011-07-15 | Hoffmann La Roche | Pyrazolo-pyrimidin-derivate als mglur2- antagonisten |
PL1863818T3 (pl) | 2005-03-23 | 2010-08-31 | Hoffmann La Roche | Pochodne acetylenylo-pirazolo-pirymidyny jako antagoniści MGLUR2 |
EP1934214B1 (en) | 2005-09-27 | 2010-04-07 | F.Hoffmann-La Roche Ag | Oxadiazolyl pyrazolo-pyrimidines as mglur2 antagonists |
WO2009014620A1 (en) * | 2007-07-20 | 2009-01-29 | Merck & Co., Inc. | Pyrazolo[1,5-a]pyrimidine derivatives |
CN101671336B (zh) * | 2009-09-23 | 2013-11-13 | 辽宁利锋科技开发有限公司 | 芳杂环并嘧啶衍生物和类似物及其制备方法和用途 |
US9447099B2 (en) * | 2011-10-04 | 2016-09-20 | Hoffmann-La Roche Inc. | Methods for the preparation of 5-[2-[7 (trifluoromethyl)-5-[4-(trifluoromethyl)phenyl]pyrazolo [1,5-A]pyrimidin-3-yl[ethynyl]-2-pyridinamine |
CN104662002A (zh) * | 2012-07-27 | 2015-05-27 | 比亚尔-珀特拉和Ca股份公司 | 取代脲类化合物的合成方法 |
WO2014064028A1 (en) | 2012-10-23 | 2014-05-01 | F. Hoffmann-La Roche Ag | Mglu2/3 antagonists for the treatment of autistic disorders |
KR102148681B1 (ko) | 2013-02-21 | 2020-08-27 | 칼리토르 사이언시즈, 엘엘씨 | Pi3 키나제 모듈레이터로서의 헤테로방향족 화합물 |
TW201542550A (zh) | 2013-09-06 | 2015-11-16 | Lexicon Pharmaceuticals Inc | 吡唑并[1,5-a]嘧啶基化合物、包含彼之組合物以及使用彼之方法 |
CN104193745B (zh) * | 2014-07-30 | 2016-09-28 | 斯芬克司药物研发(天津)股份有限公司 | 一种咪唑并嘧啶羧酸类化合物及其制备方法 |
AU2015295300B2 (en) * | 2014-08-01 | 2019-05-02 | Janssen Pharmaceutica Nv | 6,7-dihydropyrazolo[1,5-a]pyrazin-4(5h)-one compounds and their use as negative allosteric modulators of mGluR2 receptors |
EP3000814A1 (en) | 2014-09-26 | 2016-03-30 | Domain Therapeutics | Substituted pyrazoloquinazolinones and pyrroloquinazolinones as allosteric modulators of group II metabotropic glutamate receptors |
ES2727158T3 (es) * | 2014-12-03 | 2019-10-14 | Janssen Pharmaceutica Nv | Ligandos para PET de mGluR2 radiomarcados |
TWI713497B (zh) * | 2015-02-26 | 2020-12-21 | 南韓商愛思開生物製藥股份有限公司 | 咪唑并嘧啶及咪唑并三衍生物及包含該衍生物之醫藥組成物 |
CN108137607B (zh) | 2015-08-26 | 2021-04-06 | 缆图药品公司 | 适用于治疗与ntrk相关的病症的化合物和组合物 |
JP2019500328A (ja) | 2015-11-19 | 2019-01-10 | ブループリント メディシンズ コーポレイション | Ntrkに関連する障害の治療のために有用な化合物及び組成物 |
AU2016374568B2 (en) | 2015-12-18 | 2020-08-27 | Janssen Pharmaceutica Nv | Radiolabelled mGluR2/3 PET ligands |
PT3389727T (pt) | 2015-12-18 | 2020-10-30 | Janssen Pharmaceutica Nv | Ligantes pet de mglur2/3 radiomarcados |
BR112020014431A2 (pt) * | 2018-01-17 | 2020-12-01 | Glaxosmithkline Intellectual Property Development Limited | inibidores de pl4kiiibeta |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT880523E (pt) | 1996-02-07 | 2007-01-31 | Neurocrine Biosciences Inc | Pirazolopirimidinas com antagonistas dos receptores de crf |
CZ299451B6 (cs) * | 1996-07-24 | 2008-07-30 | Bristol-Myers Squibb Pharma Company | [1,5-a]-Pyrazolo-1,3,5- triaziny jejich použití afarmaceutické kompozice na jejich bázi |
ATE214704T1 (de) * | 1997-07-18 | 2002-04-15 | Hoffmann La Roche | 5h-thiazolo(3,2-a)pyrimidinderivate |
AU4203500A (en) * | 1999-04-06 | 2000-10-23 | Du Pont Pharmaceuticals Company | Pyrazolopyrimidines as crf antagonists |
HUP0400851A3 (en) | 2001-04-12 | 2010-03-29 | Hoffmann La Roche | Dihydro-benzo[b][1,4]diazepin-2-one derivatives as mglur2 antagonists ii, process for their preparation and pharmaceutical compositions containing them |
GB0128499D0 (en) | 2001-11-28 | 2002-01-23 | Merck Sharp & Dohme | Therapeutic agents |
AU2002365892A1 (en) * | 2001-11-30 | 2003-06-17 | Merck & Co., Inc. | Metabotropic glutamate receptor-5 modulators |
US7329662B2 (en) * | 2003-10-03 | 2008-02-12 | Hoffmann-La Roche Inc. | Pyrazolo-pyridine |
-
2004
- 2004-09-24 US US10/948,970 patent/US7329662B2/en not_active Expired - Fee Related
- 2004-09-27 CA CA2540768A patent/CA2540768C/en not_active Expired - Fee Related
- 2004-09-27 MX MXPA06003526A patent/MXPA06003526A/es active IP Right Grant
- 2004-09-27 AT AT04765633T patent/ATE512148T1/de active
- 2004-09-27 RU RU2006114749/04A patent/RU2350616C2/ru not_active IP Right Cessation
- 2004-09-27 EP EP04765633A patent/EP1670801B1/en not_active Expired - Lifetime
- 2004-09-27 CN CN2008100836319A patent/CN101239981B/zh not_active Expired - Fee Related
- 2004-09-27 AU AU2004283801A patent/AU2004283801B2/en not_active Ceased
- 2004-09-27 ES ES04765633T patent/ES2364753T3/es not_active Expired - Lifetime
- 2004-09-27 NZ NZ546037A patent/NZ546037A/en unknown
- 2004-09-27 WO PCT/EP2004/010807 patent/WO2005040171A1/en active Application Filing
- 2004-09-27 JP JP2006530027A patent/JP4551402B2/ja not_active Expired - Fee Related
- 2004-09-27 BR BRPI0414948-3A patent/BRPI0414948A/pt not_active IP Right Cessation
- 2004-09-27 KR KR1020077018904A patent/KR20070096033A/ko not_active Application Discontinuation
- 2004-09-27 KR KR1020067006303A patent/KR100781469B1/ko not_active IP Right Cessation
- 2004-09-27 CN CNB2004800357899A patent/CN100522964C/zh not_active Expired - Fee Related
- 2004-09-30 TW TW093129636A patent/TWI297691B/zh active
- 2004-10-01 AR ARP040103565A patent/AR045959A1/es unknown
-
2006
- 2006-03-23 IL IL174512A patent/IL174512A0/en not_active IP Right Cessation
- 2006-03-24 NO NO20061363A patent/NO20061363L/no not_active Application Discontinuation
- 2006-03-31 ZA ZA200602677A patent/ZA200602677B/en unknown
- 2006-04-03 CO CO06032493A patent/CO5680437A2/es not_active Application Discontinuation
-
2007
- 2007-02-16 US US11/707,480 patent/US7514443B2/en not_active Expired - Fee Related
- 2007-06-18 HK HK07106520.9A patent/HK1099302A1/xx not_active IP Right Cessation
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20130927 |