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HK1086841A1 - A method for the preparation of enantiomerically pure mirtazapine - Google Patents

A method for the preparation of enantiomerically pure mirtazapine

Info

Publication number
HK1086841A1
HK1086841A1 HK06109133.3A HK06109133A HK1086841A1 HK 1086841 A1 HK1086841 A1 HK 1086841A1 HK 06109133 A HK06109133 A HK 06109133A HK 1086841 A1 HK1086841 A1 HK 1086841A1
Authority
HK
Hong Kong
Prior art keywords
preparation
enantiomerically pure
pure mirtazapine
mirtazapine
enantiomerically
Prior art date
Application number
HK06109133.3A
Other languages
English (en)
Inventor
Johannes Hubertus Wieringa
De Ven Adrianus Antonius Martinus Van
Original Assignee
Organon Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Organon Nv filed Critical Organon Nv
Publication of HK1086841A1 publication Critical patent/HK1086841A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
HK06109133.3A 2003-07-10 2006-08-17 A method for the preparation of enantiomerically pure mirtazapine HK1086841A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03102095 2003-07-10
PCT/EP2004/051357 WO2005005410A1 (en) 2003-07-10 2004-07-05 A method for the preparation of enantiomerically pure mirtazapine

Publications (1)

Publication Number Publication Date
HK1086841A1 true HK1086841A1 (en) 2006-09-29

Family

ID=34042934

Family Applications (1)

Application Number Title Priority Date Filing Date
HK06109133.3A HK1086841A1 (en) 2003-07-10 2006-08-17 A method for the preparation of enantiomerically pure mirtazapine

Country Status (36)

Country Link
US (2) US8058436B2 (es)
EP (1) EP1656365B1 (es)
JP (1) JP4668184B2 (es)
KR (1) KR20060056315A (es)
CN (1) CN100558722C (es)
AR (1) AR046494A1 (es)
AT (1) ATE433965T1 (es)
AU (1) AU2004255874B2 (es)
BR (1) BRPI0412447A (es)
CA (1) CA2531165C (es)
CO (1) CO5640123A2 (es)
CY (1) CY1109327T1 (es)
DE (1) DE602004021605D1 (es)
DK (1) DK1656365T3 (es)
EC (1) ECSP066271A (es)
ES (1) ES2327123T3 (es)
HK (1) HK1086841A1 (es)
HR (1) HRP20051019A2 (es)
IL (1) IL172549A0 (es)
IS (1) IS2674B (es)
LT (1) LT5382B (es)
LV (1) LV13441B (es)
MX (1) MXPA06000325A (es)
NO (1) NO20056175L (es)
NZ (1) NZ544360A (es)
PE (1) PE20050323A1 (es)
PL (1) PL1656365T3 (es)
PT (1) PT1656365E (es)
RS (1) RS20050972A (es)
RU (1) RU2352566C2 (es)
SG (1) SG144914A1 (es)
SI (1) SI1656365T1 (es)
TW (1) TWI335915B (es)
UA (1) UA83666C2 (es)
WO (1) WO2005005410A1 (es)
ZA (1) ZA200600019B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5080050B2 (ja) * 2005-09-26 2012-11-21 住友化学株式会社 光学活性なピペラジン化合物の製造方法
WO2007035003A1 (ja) * 2005-09-26 2007-03-29 Sumitomo Chemical Company, Limited 光学活性なピペラジン化合物の製造方法
TW200808804A (en) * 2006-05-22 2008-02-16 Organon Nv Mirtazapine for the treatment of neuropathic pain
TW200815370A (en) * 2006-06-16 2008-04-01 Organon Nv Stereoselective synthesis of (S)-1-methyl-3-phenylpiperazine
US8273883B2 (en) 2007-02-09 2012-09-25 Kaneka Corporation Method for producing optically active 2-arylpiperazine derivative
JP5192707B2 (ja) * 2007-03-22 2013-05-08 住友化学株式会社 ミルタザピンの製造方法
CA2684021A1 (en) * 2007-04-11 2008-10-23 N.V. Organon A method for the preparation of an enantiomer of a tetracyclic benzazepine
US7994314B2 (en) 2007-04-11 2011-08-09 N.V. Organon Method for the preparation of an enantiomerically pure benzazepine
KR101485418B1 (ko) * 2013-05-29 2015-01-26 주식회사 메디켐코리아 고순도 미르타자핀의 제조방법
HUE055000T2 (hu) 2015-02-27 2021-10-28 Dechra Ltd Étvágy stimulálása, tömegvesztés kézbentartása és anorexia kezelése kutyák és macskák esetében
KR102540021B1 (ko) * 2020-12-02 2023-06-07 (주)유케이케미팜 대량 생산에 적합한 미르타자핀의 제조방법

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3959470A (en) * 1972-11-28 1976-05-25 Mikhail Davidovich Mashkovsky Psychotropic medicinal preparation
NL189199C (nl) * 1975-04-05 1993-02-01 Akzo Nv Werkwijze ter bereiding van farmaceutische preparaten met werking op het centraal zenuwstelsel op basis van benz(aryl)azepinederivaten, de verkregen gevormde farmaceutische preparaten, alsmede werkwijze ter bereiding van de toe te passen benz(aryl)azepinederivaten.
IE903557A1 (en) * 1989-10-05 1991-04-10 Sankyo Co Novel tetracyclic compounds having anti-allergic and¹anti-asthmatic activities, their preparation and use
JPH11222407A (ja) * 1997-11-14 1999-08-17 Sankyo Co Ltd 新規殺菌剤
PL192272B1 (pl) 1997-11-14 2006-09-29 Akzo Nobel Nv Zastosowanie mirtazapiny
US20030069417A1 (en) * 1999-04-19 2003-04-10 Claude Singer Novel synthesis and crystallization of piperazine ring-containing compounds
WO2000062782A1 (en) 1999-04-19 2000-10-26 Teva Pharmaceutical Industries Ltd. Novel synthesis and crystallization of piperazine ring-containing compounds
US6068695A (en) * 1999-07-13 2000-05-30 Bayer Corporation Process for the continuous preparation of quinacridones
AU6476300A (en) 1999-09-30 2001-05-10 Sumika Fine Chemicals Co., Ltd. Process for the preparation of a piperazine derivative
WO2001042239A1 (fr) 1999-12-13 2001-06-14 Sumika Fine Chemicals Co., Ltd. Procede de preparation d'un compose pyridinemethanol
ATE317261T1 (de) 2000-02-11 2006-02-15 Akzo Nobel Nv Verwendung von mirtazapin zur behandlung von schlafstörungen
JP2001342188A (ja) * 2000-03-27 2001-12-11 Takeda Chem Ind Ltd 縮合ピラゾール誘導体、その製造法および用途
TW200538100A (en) * 2004-04-21 2005-12-01 Akzo Nobel Nv Mirtazapine salts

Also Published As

Publication number Publication date
RU2352566C2 (ru) 2009-04-20
DK1656365T3 (da) 2009-09-14
NZ544360A (en) 2008-05-30
EP1656365A1 (en) 2006-05-17
AR046494A1 (es) 2005-12-14
ECSP066271A (es) 2006-07-28
LV13441B (en) 2006-08-20
PL1656365T3 (pl) 2009-10-30
RS20050972A (en) 2008-06-05
IS8184A (is) 2005-12-15
ES2327123T3 (es) 2009-10-26
MXPA06000325A (es) 2006-03-30
LT5382B (lt) 2006-11-27
IL172549A0 (en) 2006-04-10
CY1109327T1 (el) 2014-07-02
CO5640123A2 (es) 2006-05-31
HRP20051019A2 (en) 2006-02-28
AU2004255874A1 (en) 2005-01-20
TW200510426A (en) 2005-03-16
UA83666C2 (ru) 2008-08-11
KR20060056315A (ko) 2006-05-24
SI1656365T1 (sl) 2009-10-31
SG144914A1 (en) 2008-08-28
ATE433965T1 (de) 2009-07-15
US20060229300A1 (en) 2006-10-12
AU2004255874B2 (en) 2010-10-28
EP1656365B1 (en) 2009-06-17
CA2531165A1 (en) 2005-01-20
CA2531165C (en) 2011-08-30
BRPI0412447A (pt) 2006-09-19
PT1656365E (pt) 2009-09-01
PE20050323A1 (es) 2005-05-16
IS2674B (is) 2010-09-15
JP4668184B2 (ja) 2011-04-13
US8058436B2 (en) 2011-11-15
WO2005005410A1 (en) 2005-01-20
US20100179319A1 (en) 2010-07-15
TWI335915B (en) 2011-01-11
CN1820000A (zh) 2006-08-16
RU2006103992A (ru) 2006-06-27
ZA200600019B (en) 2007-01-31
NO20056175L (no) 2006-01-23
JP2009513537A (ja) 2009-04-02
LT2005107A (en) 2006-06-27
DE602004021605D1 (de) 2009-07-30
CN100558722C (zh) 2009-11-11

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20130705