DK1656365T3 - Fremgangsmåde til fremstilling af enantiomerisk rent mirtazapin - Google Patents

Fremgangsmåde til fremstilling af enantiomerisk rent mirtazapin

Info

Publication number: DK1656365T3
Authority: DK; Denmark
Prior art keywords: preparation; enantiomerically pure; pure mirtazapine; mirtazapine; enantiomerically
Prior art date: 2003-07-10

Application number

DK04741958T

Other languages

English (en)

Inventor

Johannes Hubertus Wieringa

De Ven Adrianus Antonius Martinus Van

Gerardus Johannes Kemperman

Original Assignee

Organon Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-07-10

Filing date

2004-07-05

Publication date

2009-09-14

2004-07-05 Application filed by Organon Nv filed Critical Organon Nv

2009-09-14 Application granted granted Critical

2009-09-14 Publication of DK1656365T3 publication Critical patent/DK1656365T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Neurology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DK04741958T 2003-07-10 2004-07-05 Fremgangsmåde til fremstilling af enantiomerisk rent mirtazapin DK1656365T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP03102095		2003-07-10
PCT/EP2004/051357 WO2005005410A1 (en)	2003-07-10	2004-07-05	A method for the preparation of enantiomerically pure mirtazapine

Publications (1)

Publication Number	Publication Date
DK1656365T3 true DK1656365T3 (da)	2009-09-14

Family

ID=34042934

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK04741958T DK1656365T3 (da)	2003-07-10	2004-07-05	Fremgangsmåde til fremstilling af enantiomerisk rent mirtazapin

Country Status (36)

Country	Link
US (2)	US8058436B2 (da)
EP (1)	EP1656365B1 (da)
JP (1)	JP4668184B2 (da)
KR (1)	KR20060056315A (da)
CN (1)	CN100558722C (da)
AR (1)	AR046494A1 (da)
AT (1)	ATE433965T1 (da)
AU (1)	AU2004255874B2 (da)
BR (1)	BRPI0412447A (da)
CA (1)	CA2531165C (da)
CO (1)	CO5640123A2 (da)
CY (1)	CY1109327T1 (da)
DE (1)	DE602004021605D1 (da)
DK (1)	DK1656365T3 (da)
EC (1)	ECSP066271A (da)
ES (1)	ES2327123T3 (da)
HK (1)	HK1086841A1 (da)
HR (1)	HRP20051019A2 (da)
IL (1)	IL172549A0 (da)
IS (1)	IS2674B (da)
LT (1)	LT5382B (da)
LV (1)	LV13441B (da)
MX (1)	MXPA06000325A (da)
NO (1)	NO20056175L (da)
NZ (1)	NZ544360A (da)
PE (1)	PE20050323A1 (da)
PL (1)	PL1656365T3 (da)
PT (1)	PT1656365E (da)
RS (1)	RS20050972A (da)
RU (1)	RU2352566C2 (da)
SG (1)	SG144914A1 (da)
SI (1)	SI1656365T1 (da)
TW (1)	TWI335915B (da)
UA (1)	UA83666C2 (da)
WO (1)	WO2005005410A1 (da)
ZA (1)	ZA200600019B (da)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP5080050B2 (ja) *	2005-09-26	2012-11-21	住友化学株式会社	光学活性なピペラジン化合物の製造方法
WO2007035003A1 (ja) *	2005-09-26	2007-03-29	Sumitomo Chemical Company, Limited	光学活性なピペラジン化合物の製造方法
TW200808804A (en) *	2006-05-22	2008-02-16	Organon Nv	Mirtazapine for the treatment of neuropathic pain
TW200815370A (en) *	2006-06-16	2008-04-01	Organon Nv	Stereoselective synthesis of (S)-1-methyl-3-phenylpiperazine
US8273883B2 (en)	2007-02-09	2012-09-25	Kaneka Corporation	Method for producing optically active 2-arylpiperazine derivative
JP5192707B2 (ja) *	2007-03-22	2013-05-08	住友化学株式会社	ミルタザピンの製造方法
CA2684021A1 (en) *	2007-04-11	2008-10-23	N.V. Organon	A method for the preparation of an enantiomer of a tetracyclic benzazepine
US7994314B2 (en)	2007-04-11	2011-08-09	N.V. Organon	Method for the preparation of an enantiomerically pure benzazepine
KR101485418B1 (ko) *	2013-05-29	2015-01-26	주식회사 메디켐코리아	고순도 미르타자핀의 제조방법
HUE055000T2 (hu)	2015-02-27	2021-10-28	Dechra Ltd	Étvágy stimulálása, tömegvesztés kézbentartása és anorexia kezelése kutyák és macskák esetében
KR102540021B1 (ko) *	2020-12-02	2023-06-07	(주)유케이케미팜	대량 생산에 적합한 미르타자핀의 제조방법

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3959470A (en) *	1972-11-28	1976-05-25	Mikhail Davidovich Mashkovsky	Psychotropic medicinal preparation
NL189199C (nl) *	1975-04-05	1993-02-01	Akzo Nv	Werkwijze ter bereiding van farmaceutische preparaten met werking op het centraal zenuwstelsel op basis van benz(aryl)azepinederivaten, de verkregen gevormde farmaceutische preparaten, alsmede werkwijze ter bereiding van de toe te passen benz(aryl)azepinederivaten.
IE903557A1 (en) *	1989-10-05	1991-04-10	Sankyo Co	Novel tetracyclic compounds having anti-allergic and¹anti-asthmatic activities, their preparation and use
JPH11222407A (ja) *	1997-11-14	1999-08-17	Sankyo Co Ltd	新規殺菌剤
PL192272B1 (pl)	1997-11-14	2006-09-29	Akzo Nobel Nv	Zastosowanie mirtazapiny
US20030069417A1 (en) *	1999-04-19	2003-04-10	Claude Singer	Novel synthesis and crystallization of piperazine ring-containing compounds
WO2000062782A1 (en)	1999-04-19	2000-10-26	Teva Pharmaceutical Industries Ltd.	Novel synthesis and crystallization of piperazine ring-containing compounds
US6068695A (en) *	1999-07-13	2000-05-30	Bayer Corporation	Process for the continuous preparation of quinacridones
AU6476300A (en)	1999-09-30	2001-05-10	Sumika Fine Chemicals Co., Ltd.	Process for the preparation of a piperazine derivative
WO2001042239A1 (fr)	1999-12-13	2001-06-14	Sumika Fine Chemicals Co., Ltd.	Procede de preparation d'un compose pyridinemethanol
ATE317261T1 (de)	2000-02-11	2006-02-15	Akzo Nobel Nv	Verwendung von mirtazapin zur behandlung von schlafstörungen
JP2001342188A (ja) *	2000-03-27	2001-12-11	Takeda Chem Ind Ltd	縮合ピラゾール誘導体、その製造法および用途
TW200538100A (en) *	2004-04-21	2005-12-01	Akzo Nobel Nv	Mirtazapine salts

2004
- 2004-05-07 UA UAA200600274A patent/UA83666C2/ru unknown
- 2004-06-28 TW TW093118845A patent/TWI335915B/zh not_active IP Right Cessation
- 2004-07-05 US US10/564,193 patent/US8058436B2/en not_active Expired - Fee Related
- 2004-07-05 NZ NZ544360A patent/NZ544360A/en not_active IP Right Cessation
- 2004-07-05 BR BRPI0412447-2A patent/BRPI0412447A/pt not_active IP Right Cessation
- 2004-07-05 PT PT04741958T patent/PT1656365E/pt unknown
- 2004-07-05 ES ES04741958T patent/ES2327123T3/es not_active Expired - Lifetime
- 2004-07-05 JP JP2006518216A patent/JP4668184B2/ja not_active Expired - Lifetime
- 2004-07-05 KR KR1020067000511A patent/KR20060056315A/ko active IP Right Grant
- 2004-07-05 MX MXPA06000325A patent/MXPA06000325A/es active IP Right Grant
- 2004-07-05 AU AU2004255874A patent/AU2004255874B2/en not_active Expired
- 2004-07-05 CA CA2531165A patent/CA2531165C/en not_active Expired - Fee Related
- 2004-07-05 AT AT04741958T patent/ATE433965T1/de active
- 2004-07-05 EP EP04741958A patent/EP1656365B1/en not_active Expired - Lifetime
- 2004-07-05 RS YUP-2005/0972A patent/RS20050972A/sr unknown
- 2004-07-05 CN CNB2004800194891A patent/CN100558722C/zh not_active Expired - Lifetime
- 2004-07-05 WO PCT/EP2004/051357 patent/WO2005005410A1/en active IP Right Grant
- 2004-07-05 SG SG200805127-8A patent/SG144914A1/en unknown
- 2004-07-05 PL PL04741958T patent/PL1656365T3/pl unknown
- 2004-07-05 RU RU2006103992/04A patent/RU2352566C2/ru not_active IP Right Cessation
- 2004-07-05 SI SI200431183T patent/SI1656365T1/sl unknown
- 2004-07-05 DE DE602004021605T patent/DE602004021605D1/de not_active Expired - Lifetime
- 2004-07-05 DK DK04741958T patent/DK1656365T3/da active
- 2004-07-07 PE PE2004000653A patent/PE20050323A1/es not_active Application Discontinuation
- 2004-07-08 AR ARP040102412A patent/AR046494A1/es not_active Application Discontinuation
2005
- 2005-12-12 LT LT2005107A patent/LT5382B/lt not_active IP Right Cessation
- 2005-12-13 IL IL172549A patent/IL172549A0/en not_active IP Right Cessation
- 2005-12-15 IS IS8184A patent/IS2674B/is unknown
- 2005-12-22 HR HR20051019A patent/HRP20051019A2/xx not_active Application Discontinuation
- 2005-12-23 NO NO20056175A patent/NO20056175L/no not_active Application Discontinuation
2006
- 2006-01-03 ZA ZA200600019A patent/ZA200600019B/en unknown
- 2006-01-09 EC EC2006006271A patent/ECSP066271A/es unknown
- 2006-01-10 CO CO06001617A patent/CO5640123A2/es not_active Application Discontinuation
- 2006-02-10 LV LVP-06-21A patent/LV13441B/en unknown
- 2006-08-17 HK HK06109133.3A patent/HK1086841A1/xx not_active IP Right Cessation
2008
- 2008-07-02 US US12/667,969 patent/US20100179319A1/en not_active Abandoned
2009
- 2009-08-25 CY CY20091100894T patent/CY1109327T1/el unknown

Also Published As

Publication number	Publication date
RU2352566C2 (ru)	2009-04-20
NZ544360A (en)	2008-05-30
EP1656365A1 (en)	2006-05-17
AR046494A1 (es)	2005-12-14
ECSP066271A (es)	2006-07-28
LV13441B (en)	2006-08-20
PL1656365T3 (pl)	2009-10-30
RS20050972A (en)	2008-06-05
IS8184A (is)	2005-12-15
ES2327123T3 (es)	2009-10-26
MXPA06000325A (es)	2006-03-30
LT5382B (lt)	2006-11-27
IL172549A0 (en)	2006-04-10
CY1109327T1 (el)	2014-07-02
CO5640123A2 (es)	2006-05-31
HRP20051019A2 (en)	2006-02-28
AU2004255874A1 (en)	2005-01-20
TW200510426A (en)	2005-03-16
UA83666C2 (ru)	2008-08-11
KR20060056315A (ko)	2006-05-24
SI1656365T1 (sl)	2009-10-31
SG144914A1 (en)	2008-08-28
ATE433965T1 (de)	2009-07-15
US20060229300A1 (en)	2006-10-12
AU2004255874B2 (en)	2010-10-28
HK1086841A1 (en)	2006-09-29
EP1656365B1 (en)	2009-06-17
CA2531165A1 (en)	2005-01-20
CA2531165C (en)	2011-08-30
BRPI0412447A (pt)	2006-09-19
PT1656365E (pt)	2009-09-01
PE20050323A1 (es)	2005-05-16
IS2674B (is)	2010-09-15
JP4668184B2 (ja)	2011-04-13
US8058436B2 (en)	2011-11-15
WO2005005410A1 (en)	2005-01-20
US20100179319A1 (en)	2010-07-15
TWI335915B (en)	2011-01-11
CN1820000A (zh)	2006-08-16
RU2006103992A (ru)	2006-06-27
ZA200600019B (en)	2007-01-31
NO20056175L (no)	2006-01-23
JP2009513537A (ja)	2009-04-02
LT2005107A (en)	2006-06-27
DE602004021605D1 (de)	2009-07-30
CN100558722C (zh)	2009-11-11

Publication	Publication Date	Title
DK1828164T3 (da)	2008-12-08	Fremgangsmåde til fremstilling af N-phenylpyrazol-1-carboxamider
DK1778668T3 (da)	2013-09-30	Fremgangsmåde til fremstilling af dihydropteridion
DK2058243T3 (da)	2011-12-05	Fremgangsmåde til fremstilling af drikke
DK1611108T3 (da)	2011-10-10	Fremgangsmåde til fremstilling af telmisartan
DK1720571T3 (da)	2012-09-03	Fremgangsmåde til behandling af hæmolytisk sygdom
DK1546122T3 (da)	2008-03-03	Fremgangsmåde til fremstilling af valsartan
DK1667967T3 (da)	2012-10-08	Fremgangsmåde til fremstilling af 2-oxo-1-pyrrolidin-derivater
DK1407037T3 (da)	2006-05-22	Fremgangsmåde til fremstilling af tagatose
DK1578731T3 (da)	2010-02-15	Fremgangsmåde til fremstilling af pyrimidinforbindelser
DK1756049T3 (da)	2008-02-25	Fremgangsmåde til fremstilling af 1,4-diphenylazetidinon-derivater
DK1656365T3 (da)	2009-09-14	Fremgangsmåde til fremstilling af enantiomerisk rent mirtazapin
DK1678135T3 (da)	2009-09-07	Fremgangsm de til fremstilling af n-amino-substituerede hetorocykliske forbindelser
DK1575941T3 (da)	2012-07-09	Fremgangsmåde til fremstilling af (S)-pantoprazol
DK1572613T3 (da)	2006-12-18	Fremgangsmåde til fremstilling af benzophenoner
DK1682541T3 (da)	2010-06-28	Fremgangsmåde til fremstilling af tiotropiumsalte
DK1831223T3 (da)	2013-06-10	Fremgangsmåde til fremstilling af L-biopterin
DK1838683T3 (da)	2009-08-10	Fremgangsmåde til fremstilling af [1,4,5]-oxadiazepinderivater
DK1511724T3 (da)	2014-06-16	Fremgangsmåde til fremstilling af thioalkylaminderivater
DK1692137T3 (da)	2007-04-30	Fremgangsmåde til fremstilling af tubulinininhibitorer
DK1805316T3 (da)	2009-08-10	Fremgangsmåde til fremstilling af de enantiomere former af cis-3-hydroxycy-
DK1503995T3 (da)	2008-04-21	Fremgangsmåde til fremstilling af substituerede phenylsulfonylurinstoffer
DK1519936T3 (da)	2008-03-03	Fremgangsmåde til fremstilling af nevirapin
DK1794152T3 (da)	2008-11-17	Fremgangsmåde til fremstilling af enantiomeriske imidazol-forbindelser
DK1685104T3 (da)	2008-04-14	Fremgangsmåde til fremstilling af N-substituerede phthalomider
DK1606246T3 (da)	2010-09-06	Fremgangsmåde til fremstilling af 2-cyan-3-hydroxy-N-(phenyl)but-2-enamider