HK1058361A1 - Urea derivatives as integrin alpha 4 antagonists - Google Patents
Urea derivatives as integrin alpha 4 antagonistsInfo
- Publication number
- HK1058361A1 HK1058361A1 HK04101137A HK04101137A HK1058361A1 HK 1058361 A1 HK1058361 A1 HK 1058361A1 HK 04101137 A HK04101137 A HK 04101137A HK 04101137 A HK04101137 A HK 04101137A HK 1058361 A1 HK1058361 A1 HK 1058361A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- antagonists
- urea derivatives
- integrin alpha
- integrin
- alpha
- Prior art date
Links
- 102100032818 Integrin alpha-4 Human genes 0.000 title 1
- 108010041012 Integrin alpha4 Proteins 0.000 title 1
- 239000005557 antagonist Substances 0.000 title 1
- 150000003672 ureas Chemical class 0.000 title 1
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- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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- C07D213/40—Acylated substituent nitrogen atom
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- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
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- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
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Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES200100126A ES2200617B1 (es) | 2001-01-19 | 2001-01-19 | Derivados de urea como antagonistas de integrinas alfa 4. |
PCT/EP2002/000331 WO2002057242A2 (fr) | 2001-01-19 | 2002-01-15 | Derives d'uree en tant qu'antagonistes d'alpha4 integrine |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1058361A1 true HK1058361A1 (en) | 2004-05-14 |
Family
ID=8496447
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK04101137A HK1058361A1 (en) | 2001-01-19 | 2004-02-18 | Urea derivatives as integrin alpha 4 antagonists |
Country Status (33)
Country | Link |
---|---|
US (2) | US7253171B2 (fr) |
EP (1) | EP1383750B1 (fr) |
JP (1) | JP4173003B2 (fr) |
KR (1) | KR100861471B1 (fr) |
CN (1) | CN100536839C (fr) |
AR (1) | AR032256A1 (fr) |
AT (1) | ATE374191T1 (fr) |
AU (1) | AU2002228048B2 (fr) |
BG (1) | BG108004A (fr) |
BR (1) | BR0206588A (fr) |
CA (1) | CA2434939A1 (fr) |
CY (1) | CY1107086T1 (fr) |
CZ (1) | CZ20031964A3 (fr) |
DE (1) | DE60222647T2 (fr) |
DK (1) | DK1383750T3 (fr) |
EC (1) | ECSP034707A (fr) |
EE (1) | EE200300327A (fr) |
ES (2) | ES2200617B1 (fr) |
HK (1) | HK1058361A1 (fr) |
HU (1) | HUP0303722A3 (fr) |
IL (1) | IL156939A0 (fr) |
MX (1) | MXPA03006363A (fr) |
MY (1) | MY129423A (fr) |
NO (1) | NO327002B1 (fr) |
NZ (1) | NZ527031A (fr) |
PL (1) | PL369120A1 (fr) |
PT (1) | PT1383750E (fr) |
RU (1) | RU2296120C2 (fr) |
SK (1) | SK9232003A3 (fr) |
UA (1) | UA81603C2 (fr) |
UY (1) | UY27127A1 (fr) |
WO (1) | WO2002057242A2 (fr) |
ZA (1) | ZA200305535B (fr) |
Families Citing this family (32)
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US6960597B2 (en) | 2000-06-30 | 2005-11-01 | Orth-Mcneil Pharmaceutical, Inc. | Aza-bridged-bicyclic amino acid derivatives as α4 integrin antagonists |
ES2219177B1 (es) * | 2003-05-05 | 2006-02-16 | Almirall Prodesfarma, S.A. | Derivados de n-(2-feniletil) sulfamida como antagonistas de la integrina alfa4. |
WO2005019193A2 (fr) * | 2003-08-20 | 2005-03-03 | Smithkline Beecham Corporation | Composés de phényl-urée |
KR101484741B1 (ko) * | 2005-08-18 | 2015-01-21 | 닛산 가가쿠 고교 가부시키 가이샤 | 술포닐기를 갖는 티오펜 화합물 및 그 제조법 |
WO2007060409A1 (fr) * | 2005-11-23 | 2007-05-31 | Astrazeneca Ab | Derives de l-alanine |
KR100588821B1 (ko) * | 2006-01-06 | 2006-06-12 | 모악개발 주식회사 | 균일 팽창이 가능한 패커를 구비하는 하수관로 부분보수장치 |
JP2009539815A (ja) * | 2006-06-09 | 2009-11-19 | アストラゼネカ アクチボラグ | 固形腫瘍の治療用のa5b1アンタゴニストとしてのN−(ベンゾイル)−O−[2−(ピリジン−2−イルアミノ)エチル]−L−チロシン誘導体と関連化合物 |
US20090062267A1 (en) * | 2007-01-29 | 2009-03-05 | Astrazeneca Ab | L-ALANINE DERIVATIVES AS a5beta1 ANTAGONISTS |
MX2009008253A (es) * | 2007-01-31 | 2009-10-12 | Vertex Pharma | Derivados de 2-aminopiridina utiles como inhibidores de cinasa. |
ES2320955B1 (es) | 2007-03-02 | 2010-03-16 | Laboratorios Almirall S.A. | Nuevos derivados de 3-((1,2,4)triazolo(4,3-a)piridin-7-il)benzamida. |
WO2008125811A1 (fr) * | 2007-04-11 | 2008-10-23 | Astrazeneca Ab | DÉRIVÉS DE N-[HÉTÉROARYLCARBONYL]-S-THIÉNYL-L-ALANINE EN TANT QU'ANTAGONISTES DE L'INTÉGRINE α5β1 |
EP2108641A1 (fr) | 2008-04-11 | 2009-10-14 | Laboratorios Almirall, S.A. | Nouveaux dérivés substitués de spiro[cycloalkyl-1,3'-indo]-2'(1'H)-one et leur utilisation comme ihibiteurs de p38 mitogen-activated kinase |
EP2113503A1 (fr) | 2008-04-28 | 2009-11-04 | Laboratorios Almirall, S.A. | Nouveaux dérivés d'indolin-2-one substitués et leur utilisation comme inhibiteurs de p38 mitogen-activated kinase |
US8569337B2 (en) | 2008-07-23 | 2013-10-29 | Vertex Pharmaceuticals Incorporated | Tri-cyclic pyrazolopyridine kinase inhibitors |
CA2731451A1 (fr) | 2008-07-23 | 2010-01-28 | Vertex Pharmaceuticals Incorporated | Inhibiteurs de la pyrazolopyridine kinase |
CN102131809A (zh) | 2008-07-23 | 2011-07-20 | 沃泰克斯药物股份有限公司 | 三环吡唑并吡啶激酶抑制剂 |
MX2011001319A (es) * | 2008-08-06 | 2011-04-05 | Vertex Pharma | Inhibidores de aminopiridina cinasa. |
KR101038486B1 (ko) * | 2008-09-03 | 2011-06-01 | 쌍용건설 주식회사 | 패커를 이용한 비굴착식 하수관로 보수 장치 및 방법 |
CN102272101A (zh) * | 2008-12-05 | 2011-12-07 | 分子制药洞察公司 | 用于癌症治疗和成像的ca-ix特异性放射性药物 |
CN102459259A (zh) | 2009-05-06 | 2012-05-16 | 沃泰克斯药物股份有限公司 | 吡唑并吡啶类 |
FI20095678A0 (fi) * | 2009-06-16 | 2009-06-16 | Biotie Therapies Oy | Ureasubstituoituja sulfoniamidijohdannaisia |
EP2322176A1 (fr) | 2009-11-11 | 2011-05-18 | Almirall, S.A. | Nouveaux dérivés de 7-phényl-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one |
WO2011094273A1 (fr) | 2010-01-27 | 2011-08-04 | Vertex Pharmaceuticals Incorporated | Inhibiteurs de la pyrazolopyridine kinase |
CN102869663A (zh) | 2010-01-27 | 2013-01-09 | 沃泰克斯药物股份有限公司 | 吡唑并吡嗪激酶抑制剂 |
AU2011209651A1 (en) | 2010-01-27 | 2012-08-09 | Vertex Pharmaceuticals Incorporated | Pyrazolopyrimidine kinase inhibitors |
US20130273034A1 (en) * | 2010-09-03 | 2013-10-17 | Kenneth W. Bair | Novel compounds and compositions for the inhibition of nampt |
JP6463366B2 (ja) | 2013-10-10 | 2019-01-30 | イースタン バージニア メディカル スクール | 12−リポキシゲナーゼ阻害物質としての4−((2−ヒドロキシ−3−メトキシベンジル)アミノ)ベンゼンスルホンアミド誘導体 |
JP7189368B2 (ja) | 2018-10-30 | 2022-12-13 | ギリアード サイエンシーズ, インコーポレイテッド | アルファ4ベータ7インテグリンの阻害のための化合物 |
AU2019373244B2 (en) | 2018-10-30 | 2022-05-26 | Gilead Sciences, Inc. | Imidazopyridine derivatives as alpha4beta7 integrin inhibitors |
AU2019373240B2 (en) | 2018-10-30 | 2023-04-20 | Gilead Sciences, Inc. | Quinoline derivatives as alpha4beta7 integrin inhibitors |
JP7189369B2 (ja) | 2018-10-30 | 2022-12-13 | ギリアード サイエンシーズ, インコーポレイテッド | アルファ4β7インテグリンの阻害のための化合物 |
JP7491996B2 (ja) | 2019-08-14 | 2024-05-28 | ギリアード サイエンシーズ, インコーポレイテッド | α4β7インテグリンの阻害のための化合物 |
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US4740611A (en) * | 1986-10-30 | 1988-04-26 | The Standard Oil Company | N,N'-disubstituted ureas |
US4705864A (en) * | 1986-11-10 | 1987-11-10 | The Standard Oil Company | Aryl oxime derivatives of hydantoins |
WO1992008464A1 (fr) * | 1990-11-15 | 1992-05-29 | Tanabe Seiyaku Co. Ltd. | Composes d'uree substitues et composes associes utilises dans la modulation de l'adhesion cellulaire |
PT900211E (pt) | 1996-04-23 | 2003-10-31 | Upjohn Co | Tiadiazolil(tio)ureias uteis como inibidores de metaloproteases com matriz |
WO1998004913A1 (fr) | 1996-07-25 | 1998-02-05 | Biogen, Inc. | Modele moleculaire pour inhibiteurs vl4-4 |
WO1998007718A1 (fr) * | 1996-08-22 | 1998-02-26 | Warner-Lambert Company | Antagonistes du recepteur de bombesine non peptidiques |
EP0998282A4 (fr) | 1997-05-29 | 2000-08-30 | Merck & Co Inc | Sulfamides utilises en tant qu'inhibiteurs de l'adherence cellulaire |
EP0991619B1 (fr) | 1997-06-23 | 2003-09-10 | Tanabe Seiyaku Co., Ltd. | Inhibiteurs d'adherence cellulaire induite par alpha 4-beta 1 |
DE69824433D1 (en) | 1997-08-28 | 2004-07-15 | Biovitrum Ab | Proteintyrosinphosphatase inhibitoren |
WO1999020617A1 (fr) * | 1997-10-21 | 1999-04-29 | Active Biotech Ab | Urees thiadiazoles anti-inflammatoires agissant comme inhibiteurs lfa-1 et mac-1 |
NZ503491A (en) | 1997-11-10 | 2002-08-28 | Bristol Myers Squibb Co | 2-substituted amino-1,3-benzothiazole derivatives useful as protein tyrosine kinase inhibitors |
WO1999026921A1 (fr) | 1997-11-24 | 1999-06-03 | Merck & Co., Inc. | DERIVES D'ALANINE-β AGISSANT EN TANT QU'INHIBITEURS DE L'ADHESION CELLULAIRE |
US6645939B1 (en) | 1997-11-24 | 2003-11-11 | Merck & Co., Inc. | Substituted β-alanine derivatives as cell adhesion inhibitors |
PT1040111E (pt) | 1997-12-17 | 2005-10-31 | Merck & Co Inc | Antagonistas do receptor da integrina |
CA2284864A1 (fr) | 1998-01-21 | 1999-07-29 | Zymogenetics, Inc. | Dialkylurees utilisees en tant que substances imitant la calcitonine |
PL348260A1 (en) * | 1998-12-16 | 2002-05-20 | Bayer Ag | New biphenyl and biphenyl-analogous compounds as integrin antagonists |
WO2000043415A1 (fr) | 1999-01-25 | 2000-07-27 | Elan Pharmaceuticals, Inc. | Composes inhibant l'adhesion des leucocytaire provoquee par vla-4 |
CA2361162A1 (fr) | 1999-03-01 | 2000-09-08 | Elan Pharmaceuticals, Inc. | Derives de l'acide alpha-aminoacetique antagonistes du recepteur alpha 4 beta 7 |
DE19909979A1 (de) | 1999-03-06 | 2000-09-07 | Bayer Ag | Verfahren zur Herstellung von Glycokonjugaten von 20(S)-Camptothecin |
TR200201920T2 (tr) | 1999-05-07 | 2002-09-23 | Texas Biotechnology Corporation | İntegrinlerin reseptörlerine bağlanmasını engelleyen karboksilik asit türevleri. |
US6518283B1 (en) | 1999-05-28 | 2003-02-11 | Celltech R&D Limited | Squaric acid derivatives |
AU6909300A (en) * | 1999-08-20 | 2001-03-19 | Merck & Co., Inc. | Substituted ureas as cell adhesion inhibitors |
-
2001
- 2001-01-19 ES ES200100126A patent/ES2200617B1/es not_active Expired - Fee Related
-
2002
- 2002-01-15 CZ CZ20031964A patent/CZ20031964A3/cs unknown
- 2002-01-15 SK SK923-2003A patent/SK9232003A3/sk not_active Application Discontinuation
- 2002-01-15 US US10/466,665 patent/US7253171B2/en not_active Expired - Fee Related
- 2002-01-15 MX MXPA03006363A patent/MXPA03006363A/es active IP Right Grant
- 2002-01-15 BR BR0206588-6A patent/BR0206588A/pt not_active IP Right Cessation
- 2002-01-15 AT AT02710010T patent/ATE374191T1/de not_active IP Right Cessation
- 2002-01-15 IL IL15693902A patent/IL156939A0/xx unknown
- 2002-01-15 PL PL02369120A patent/PL369120A1/xx unknown
- 2002-01-15 ES ES02710010T patent/ES2291448T3/es not_active Expired - Lifetime
- 2002-01-15 EE EEP200300327A patent/EE200300327A/xx unknown
- 2002-01-15 CN CNB028065255A patent/CN100536839C/zh not_active Expired - Fee Related
- 2002-01-15 DK DK02710010T patent/DK1383750T3/da active
- 2002-01-15 WO PCT/EP2002/000331 patent/WO2002057242A2/fr active IP Right Grant
- 2002-01-15 EP EP02710010A patent/EP1383750B1/fr not_active Expired - Lifetime
- 2002-01-15 DE DE60222647T patent/DE60222647T2/de not_active Expired - Lifetime
- 2002-01-15 AU AU2002228048A patent/AU2002228048B2/en not_active Ceased
- 2002-01-15 NZ NZ527031A patent/NZ527031A/en unknown
- 2002-01-15 HU HU0303722A patent/HUP0303722A3/hu unknown
- 2002-01-15 KR KR1020037009578A patent/KR100861471B1/ko not_active IP Right Cessation
- 2002-01-15 UA UA2003076827A patent/UA81603C2/ru unknown
- 2002-01-15 JP JP2002557923A patent/JP4173003B2/ja not_active Expired - Fee Related
- 2002-01-15 RU RU2003125367/04A patent/RU2296120C2/ru not_active IP Right Cessation
- 2002-01-15 CA CA002434939A patent/CA2434939A1/fr not_active Abandoned
- 2002-01-15 PT PT02710010T patent/PT1383750E/pt unknown
- 2002-01-18 MY MYPI20020184A patent/MY129423A/en unknown
- 2002-01-18 AR ARP020100181A patent/AR032256A1/es unknown
- 2002-01-18 UY UY27127A patent/UY27127A1/es unknown
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2003
- 2003-07-17 ZA ZA200305535A patent/ZA200305535B/en unknown
- 2003-07-18 BG BG108004A patent/BG108004A/bg unknown
- 2003-07-18 EC EC2003004707A patent/ECSP034707A/es unknown
- 2003-07-18 NO NO20033269A patent/NO327002B1/no not_active IP Right Cessation
-
2004
- 2004-02-18 HK HK04101137A patent/HK1058361A1/xx not_active IP Right Cessation
-
2007
- 2007-05-21 US US11/802,165 patent/US20070238763A1/en not_active Abandoned
- 2007-12-13 CY CY20071101582T patent/CY1107086T1/el unknown
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Legal Events
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PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20110115 |