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GR72911B - - Google Patents

Info

Publication number
GR72911B
GR72911B GR58225A GR790158225A GR72911B GR 72911 B GR72911 B GR 72911B GR 58225 A GR58225 A GR 58225A GR 790158225 A GR790158225 A GR 790158225A GR 72911 B GR72911 B GR 72911B
Authority
GR
Greece
Application number
GR58225A
Inventor
Jacques Gosteli
Ivan Ernst
Marc Lang
Robert Burns
Original Assignee
Ciba Geigy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy filed Critical Ciba Geigy
Publication of GR72911B publication Critical patent/GR72911B/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C07D205/09—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/568—Four-membered rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
GR58225A 1978-02-02 1979-01-31 GR72911B (el)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH114078 1978-02-02

Publications (1)

Publication Number Publication Date
GR72911B true GR72911B (el) 1984-01-05

Family

ID=4203421

Family Applications (1)

Application Number Title Priority Date Filing Date
GR58225A GR72911B (el) 1978-02-02 1979-01-31

Country Status (23)

Country Link
US (2) US4692442A (el)
EP (2) EP0042026B1 (el)
JP (3) JPS54119486A (el)
AR (1) AR228236A1 (el)
AT (1) AT362876B (el)
AU (1) AU519317B2 (el)
CA (1) CA1340273C (el)
CS (1) CS222279B2 (el)
DD (1) DD142342A5 (el)
DK (1) DK160099C (el)
ES (1) ES477336A1 (el)
FI (1) FI73219C (el)
GB (1) GB2013674A (el)
GR (1) GR72911B (el)
HU (1) HU182017B (el)
IE (1) IE48776B1 (el)
IL (1) IL56557A (el)
NO (1) NO158679C (el)
NZ (1) NZ189530A (el)
PL (1) PL122371B1 (el)
PT (1) PT69166A (el)
SU (1) SU925252A3 (el)
ZA (1) ZA79433B (el)

Families Citing this family (90)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5071843A (en) * 1978-07-24 1991-12-10 Merck & Co., Inc. Combination of 2-substituted carbapenems with dipeptidase inhibitors
US4880793A (en) * 1978-07-24 1989-11-14 Merck & Co., Inc. Combination of thienamycin-type antibiotics with dipeptidase inhibitors
US4282150A (en) 1978-12-18 1981-08-04 Bristol-Myers Company 2,6-Disubstituted penem compounds
US4272437A (en) 1978-12-18 1981-06-09 Bristol-Myers Company Antibacterial agents, and 4-thio azetidinone intermediates
JPS5625110A (en) * 1978-12-18 1981-03-10 Bristol Myers Co Antibacterial
ATE18558T1 (de) * 1979-01-10 1986-03-15 Schering Corp 2-penem-verbindungen, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zusammensetzungen.
IL59081A0 (en) * 1979-01-10 1980-05-30 Schering Corp 2-penem compounds and a method for preparing them
GR73623B (el) * 1979-02-24 1984-03-26 Erba Farmitalia
JPS55153789A (en) * 1979-04-11 1980-11-29 Sankyo Co Ltd Penem-3-carboxylic acid derivative and its preparation
US4374065A (en) 1979-09-21 1983-02-15 Bristol-Myers Company Antibacterial agents of the β-lactam type
US4378314A (en) 1979-09-21 1983-03-29 Bristol Myers Company Antibacterial agents and metal containing azetidinone intermediates therefore
US4443463A (en) * 1979-11-05 1984-04-17 Schering Corporation (5R,6S,8R)-6-(1-Hydroxyethyl)-2-(hydroxyalkylthio)-penem-3-carboxylates
ATE12773T1 (de) * 1980-02-28 1985-05-15 Schering Corp 2-penem-verbindungen, sie enthaltende pharmazeutische zusammensetzungen und verfahren zu ihrer herstellung.
SE8101464L (sv) * 1980-03-10 1981-09-11 Sankyo Co 2-penem-3-karboxylsyraderivat, deras framstellning och anvendning
JPS56142283A (en) * 1980-03-17 1981-11-06 Sankyo Co Ltd Penem-3-carboxylic acid derivative and its preparation
DE3176517D1 (en) * 1980-04-24 1987-12-17 Beecham Group Plc Beta-lactam compounds, their preparation and use
FR2483924A1 (fr) * 1980-06-06 1981-12-11 Sankyo Co Derives d'acide peneme-3-carboxylique, leurs procedes de preparation et leur application en therapeutique
DE3121510A1 (de) * 1980-07-04 1982-06-16 Farmitalia Carlo Erba S.p.A., 20159 Milano 6-alkyl-2-subst.-peneme und verfahren zu ihrer herstellung
DE3167198D1 (en) * 1980-08-16 1984-12-20 Beecham Group Plc Process for the preparation of 2-thio penem derivatives and intermediates therefor
ATE21105T1 (de) * 1980-11-06 1986-08-15 Hoechst Uk Ltd 7-oxo-4-thia-1-aza(3.2.0)heptan- und 7-oxo-4-thia-1-aza-(3.2.0)hept-2-en-derivate.
US4347183A (en) * 1981-02-02 1982-08-31 Schering Corporation Process for the synthesis of penems and carbapenems
JPS588084A (ja) * 1981-07-08 1983-01-18 Takeda Chem Ind Ltd （６ｒ）−置換−（５ｒ）−ペネム−３−カルボン酸誘導体およびその製造法
JPS58116487A (ja) * 1981-12-28 1983-07-11 Sumitomo Chem Co Ltd 新規なβ−ラクタム化合物及びその製造法
AU8605382A (en) * 1981-07-15 1983-01-20 Sumitomo Chemical Company, Limited Penicillins and azetidinones
JPS58198486A (ja) * 1982-05-14 1983-11-18 Sankyo Co Ltd ペネムまたはカルバペネム−３−カルボン酸誘導体およびその製法
JPS5835190A (ja) * 1981-08-25 1983-03-01 Sankyo Co Ltd ペネム−３−カルボン酸誘導体
CA1190236A (en) * 1981-10-23 1985-07-09 Edward J.J. Grabowski Antibiotic synthesis
US4411906A (en) * 1981-11-25 1983-10-25 Schering Corporation (5R,6S,8R)-6-(1-Hydroxyethyl)-2-(2-fluoroethylthio)-penem-3-carboxylates
AT379399B (de) * 1981-12-11 1985-12-27 Erba Farmitalia Verfahren zur herstellung von optisch aktiven penemen
NO831160L (no) * 1982-04-08 1983-10-10 Erba Farmitalia Fremstilling av substituerte penem-derivater
JPS591464A (ja) * 1982-06-26 1984-01-06 Sankyo Co Ltd β−ラクタム化合物及びその製法
ATE35270T1 (de) * 1982-07-08 1988-07-15 Hoechst Uk Ltd Antibakterielle penem-derivate.
US4540580A (en) * 1982-11-16 1985-09-10 Schering Corporation 2-[(1'R)-1'-Aminoalkyl]penems
EP0109362A1 (de) * 1982-11-16 1984-05-23 Ciba-Geigy Ag Heterocyclylverbindungen, Verfahren zu ihrer Herstellung, pharmazeutische Präparate, welche diese Verbindungen enthalten, und Verwendung von letzteren
US4540579A (en) * 1982-11-16 1985-09-10 Schering Corporation 2-[(R) Amino acid alkyl]penems
DE3366926D1 (en) * 1982-11-16 1986-11-20 Schering Corp Penems, pharmaceutical compositions containing them, process for preparing them
DE3372968D1 (en) * 1982-11-16 1987-09-17 Ciba Geigy Ag Heterocyclyl-thio compounds, process for their preparation, pharmaceutical compositions containing them and their use
PH21930A (en) * 1982-11-16 1988-04-08 Ciba Geigy Ag 6-hydroxy-lower alkylpenem compounds,pharmaceutical composition containing same and method of use thereof
US4435413A (en) 1983-01-28 1984-03-06 Schering Corporation (5R-6S,8R)-6-(1-Hydroxyethyl)-2-(2-glycylaminoethylthio)-penem-3-carboxylic acid
EP0345827A1 (en) * 1982-11-29 1989-12-13 Schering Corporation Process for the production of penem compounds
FI77459C (fi) * 1982-12-08 1989-03-10 Erba Farmitalia Foerfarande foer framstaellning av (5r)-penemderivat.
JPS59152387A (ja) * 1983-02-10 1984-08-31 Shionogi & Co Ltd 新規ペネム化合物
DK141784A (da) * 1983-03-14 1984-09-15 Schering Corp Penemforbindelser, fremgangsmaader til deres fremstilling samt farmaceutiske praeparater indeholdende disse
EP0125207A1 (de) * 1983-05-06 1984-11-14 Ciba-Geigy Ag 2-Tetrazolylpropyl-2-penem-Verbindungen, Verfahren zu ihrer Herstellung, pharmazeutische Präparate, welche diese Verbindungen enthalten, und Verwendung von letzteren
EP0125208A1 (de) * 1983-05-06 1984-11-14 Ciba-Geigy Ag Aminoniederalkyl-penem-Verbindungen, Verfahren zu ihrer Herstellung, pharmazeutische Präparate, welche diese Verbindungen enthalten, und Verwendung von letzteren
CA1283906C (en) * 1983-05-09 1991-05-07 Makoto Sunagawa .beta.-LACTAM COMPOUNDS AND PRODUCTION THEREOF
US4595539A (en) * 1983-06-10 1986-06-17 Pfizer Inc. Preparation of penem derivatives and azetidinone intermediates
US4619783A (en) * 1983-06-10 1986-10-28 Pfizer Inc. Process and intermediates for the preparation of penem derivatives
US4725678A (en) * 1983-06-10 1988-02-16 Pfizer Inc. Azetidinone intermediates for the preparation of penem derivatives
US4554103A (en) * 1983-07-14 1985-11-19 Schering Corporation Preparation of 4-acyloxyazetidinones from acyl nitrates and penams
GB8321677D0 (en) * 1983-08-11 1983-09-14 Erba Farmitalia Preparation of penems
US4656165A (en) * 1983-09-02 1987-04-07 Ciba-Geigy Corporation Aminomethyl penem compounds
US4584133A (en) * 1983-11-07 1986-04-22 Schering Corporation Process for the production of penems
US4587241A (en) * 1983-11-28 1986-05-06 Schering Corporation Heterocyclic substituted penems
US5229381A (en) * 1983-12-01 1993-07-20 Merck & Co., Inc. Substituted azetidinones as anti-inflammatory and antidegenerative agents
US4680391A (en) * 1983-12-01 1987-07-14 Merck & Co., Inc. Substituted azetidinones as anti-inflammatory and antidegenerative agents
US5229510A (en) * 1983-12-01 1993-07-20 Merck & Co., Inc. β-lactams useful in determining the amount of elastase in a clinical sample
US4711886A (en) * 1984-07-02 1987-12-08 Merck & Co., Inc. β-lactam derivatives as anti-inflammatory and antidegenerative agents
JPS62501556A (ja) * 1984-07-13 1987-06-25 メルシャン株式会社 新規２↓−オキソアゼチジン類、その製造方法および応用
US4617300A (en) * 1984-09-21 1986-10-14 Schering Corporation 2(N-heterocyclyl) penems
ATE93520T1 (de) * 1984-10-01 1993-09-15 Ciba Geigy Ag Verfahren zur herstellung von optisch aktiven acyloxyazetidinonen.
US4761408A (en) * 1984-11-02 1988-08-02 Ciba-Geigy Corporation Crystalline aminomethyl compound
JPH075463B2 (ja) * 1985-03-09 1995-01-25 サントリー株式会社 抗菌剤
EP0199675A1 (de) * 1985-04-17 1986-10-29 Ciba-Geigy Ag Heterocyclyl-penem-Verbindungen
ATE159021T1 (de) * 1986-01-17 1997-10-15 Beecham Group Plc Verfahren zur herstellung von penem derivaten und zwischenprodukte zu dieser herstellung
US4806637A (en) * 1986-03-17 1989-02-21 Schering Corporation 6-(Hydroxyethyl)-2-(heterocyclylthio)-penem-3-carboxylates
US4826832A (en) * 1986-05-06 1989-05-02 Ciba-Geigy Corporation Penen compounds
JP2526046B2 (ja) * 1986-12-26 1996-08-21 サントリー株式会社 ペネム誘導体、その製造法およびその用途
ES2058328T3 (es) * 1987-02-11 1994-11-01 Ciba Geigy Ag Acidos beta-lactama carboxilicos biciclicos.
US4751297A (en) * 1987-03-20 1988-06-14 Pfizer Inc. Method for preparation of azetidinone-1-oxoacetate by oxidation of the corresponding 2-hydroxyacetate
GB8713515D0 (en) * 1987-06-10 1987-07-15 Erba Farmitalia Methoxymethyl compounds
AT392903B (de) * 1987-10-08 1991-07-10 Hoechst Ag Pharmazeutische zubereitung enthaltend ein cephalosporin und ein penemantibiotikum
DE3839987A1 (de) * 1988-11-26 1990-05-31 Hoechst Ag Penemderivate und verfahren zu ihrer herstellung
US4876365A (en) * 1988-12-05 1989-10-24 Schering Corporation Intermediate compounds for preparing penems and carbapenems
US5198544A (en) * 1989-04-29 1993-03-30 Hoechst Aktiengesellschaft Process for the preparation of penem compounds
US5100880A (en) * 1991-03-20 1992-03-31 Merck & Co., Inc. Novel betalactam elastase inhibitors containing phosphorous acid derivatives at the 4-position of the 2-azetidinone
US5104862A (en) * 1991-03-20 1992-04-14 Merck & Co., Inc. Bethalactam elastase inhibitors containing phosphorous acid derivatives at the 4-position of the 2-azetidinone
GB9110507D0 (en) * 1991-05-15 1991-07-03 Smithkline Beecham Plc Chemical compounds
US5348953A (en) * 1991-06-25 1994-09-20 Merck & Co., Inc. Substituted azetidinones as anti-inflammatory and antidegenerative agents
GB9216102D0 (en) * 1992-07-29 1992-09-09 Smithkline Beecham Plc Pharmaceutical substances
WO1994010143A1 (en) * 1992-10-27 1994-05-11 Merck & Co., Inc. New substituted azetidinones as anti-inflammatory and antidegenerative agents
US5591737A (en) * 1992-12-17 1997-01-07 Merck & Co., Inc. Substituted azetidinones as anti-inflammatory and antidegenerative agents
ATE253070T1 (de) * 1995-02-17 2003-11-15 Daiichi Suntory Pharma Co Ltd Penem-derivate und sie enthaltende anti- mikrobische mittel
US5747485A (en) * 1995-04-13 1998-05-05 Merck & Co., Inc. Substituted azetidiones as anti-inflammatory and antidegenerative agents
ATE283707T1 (de) 1998-01-13 2004-12-15 Daiichi Suntory Pharma Co Ltd Antibakterille zusammensetzung zur topischen anwendung, enthaltend faropenem
JP2005239696A (ja) 2004-01-30 2005-09-08 Daiichi Suntory Pharma Co Ltd 無機物質を配合した医薬硬質カプセル剤
CN101029056B (zh) * 2006-02-28 2011-06-08 天津国韵生物材料有限公司 聚-3-羟基丁酸酯在制备β-内酰胺化合物中的用途
WO2009049086A1 (en) * 2007-10-09 2009-04-16 Larry Sutton Broad spectrum beta-lactamase inhibitors
DK2968352T3 (da) 2013-03-12 2019-01-02 Gladius Pharmaceuticals Corp Derivatiserede 3-styryl-cephalosporiner
WO2019215037A1 (de) * 2018-05-07 2019-11-14 Covestro Deutschland Ag Speichermedium und verfahren für die abtrennung, die speicherung und den transport von chlor aus chlor enthaltenden gasen

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GB1368074A (en) * 1971-02-04 1974-09-25 Beecham Group Ltd Substituted beta-lactams and their preparation
US4364865A (en) * 1975-12-08 1982-12-21 Ciba-Geigy Corporation Bicyclic unsaturated thia-aza compounds and 4-acylthio azetidinone intermediates
US4543257A (en) * 1977-10-19 1985-09-24 Merck & Co., Inc. 1-Carba-2-penem-3-carboxylic acid
US4500457A (en) * 1977-05-09 1985-02-19 Ciba-Geigy Corporation Process for preparing thia-aza compounds with a beta-lactam ring
LU77306A1 (el) * 1977-05-09 1979-01-18
US4168314A (en) * 1977-11-17 1979-09-18 Merck & Co., Inc. 6-(1'-Hydroxyethyl)-2-aminoethylthio-pen-2-em-3-carboxylic acid
US4123539A (en) * 1977-12-29 1978-10-31 Merck & Co., Inc. 6-Ethylpenicillanic acid
US4272437A (en) * 1978-12-18 1981-06-09 Bristol-Myers Company Antibacterial agents, and 4-thio azetidinone intermediates
EP0023887B1 (de) * 1979-08-01 1984-11-07 Ciba-Geigy Ag 3-Substituierte bicyclische Azetidinonderivate, Verfahren zu ihrer Herstellung und Zwischenprodukte, sowie deren Herstellung
DE3372968D1 (en) * 1982-11-16 1987-09-17 Ciba Geigy Ag Heterocyclyl-thio compounds, process for their preparation, pharmaceutical compositions containing them and their use
US4614614A (en) * 1983-03-28 1986-09-30 Ciba-Geigy Corporation Process for the manufacture of optically active azetidinones
US4656165A (en) * 1983-09-02 1987-04-07 Ciba-Geigy Corporation Aminomethyl penem compounds
US4826832A (en) * 1986-05-06 1989-05-02 Ciba-Geigy Corporation Penen compounds

Also Published As

Publication number Publication date
PT69166A (de) 1979-03-01
EP0042026A1 (de) 1981-12-23
EP0042026B1 (de) 1986-01-08
JPS54119486A (en) 1979-09-17
JPH0314037B2 (el) 1991-02-25
JPH0329789B2 (el) 1991-04-25
EP0003960A1 (de) 1979-09-19
ATA74579A (de) 1980-11-15
FI73219C (fi) 1987-09-10
NO158679C (no) 1988-10-19
DK160099C (da) 1991-06-24
DK43279A (da) 1979-08-03
US4952690A (en) 1990-08-28
PL213133A1 (el) 1980-03-10
JPH01110668A (ja) 1989-04-27
EP0003960B1 (de) 1983-06-29
JPH045677B2 (el) 1992-02-03
AT362876B (de) 1981-06-25
NO158679B (no) 1988-07-11
CS222279B2 (en) 1983-06-24
AU519317B2 (en) 1981-11-26
GB2013674A (en) 1979-08-15
DK160099B (da) 1991-01-28
ES477336A1 (es) 1979-07-01
JPS62129264A (ja) 1987-06-11
NZ189530A (en) 1982-02-23
PL122371B1 (en) 1982-07-31
US4692442A (en) 1987-09-08
IE48776B1 (en) 1985-05-15
ZA79433B (en) 1980-02-27
IL56557A0 (en) 1979-03-12
IE790191L (en) 1979-08-02
FI790321A (fi) 1979-08-03
AR228236A1 (es) 1983-02-15
DD142342A5 (de) 1980-06-18
NO790332L (no) 1979-08-03
AU4384379A (en) 1979-08-09
FI73219B (fi) 1987-05-29
HU182017B (en) 1983-12-28
IL56557A (en) 1982-01-31
CA1340273C (en) 1998-12-15
SU925252A3 (ru) 1982-04-30

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