FI88037B - Foerfarande foer framstaellning av farmaceutiskt vaerdefullt kristallint (4r,5s,6s,8r,2's,4's)-3-/4-(2-dimetylaminokarbonyl)-pyrrolidinyltio/-4-metyl-6-(1-hydroxietyl)-1-azabicyklo-/3,2,0/-hept-2-en-7-on-2-karboxylsyratrihydrat - Google Patents
Foerfarande foer framstaellning av farmaceutiskt vaerdefullt kristallint (4r,5s,6s,8r,2's,4's)-3-/4-(2-dimetylaminokarbonyl)-pyrrolidinyltio/-4-metyl-6-(1-hydroxietyl)-1-azabicyklo-/3,2,0/-hept-2-en-7-on-2-karboxylsyratrihydratInfo
- Publication number
- FI88037B FI88037B FI873299A FI873299A FI88037B FI 88037 B FI88037 B FI 88037B FI 873299 A FI873299 A FI 873299A FI 873299 A FI873299 A FI 873299A FI 88037 B FI88037 B FI 88037B
- Authority
- FI
- Finland
- Prior art keywords
- vaerdefullt
- karboxylsyratrihydrat
- framstation
- pyrrolidinylthio
- dimethylaminocarbonyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
- C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
- C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
- C07D477/20—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP17932186 | 1986-07-30 | ||
| JP17932186 | 1986-07-30 | ||
| JP15776987 | 1987-06-26 | ||
| JP15776987 | 1987-06-26 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| FI873299A0 FI873299A0 (fi) | 1987-07-29 |
| FI873299A FI873299A (fi) | 1988-01-31 |
| FI88037B true FI88037B (fi) | 1992-12-15 |
| FI88037C FI88037C (fi) | 1993-03-25 |
Family
ID=26485103
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI873299A FI88037C (fi) | 1986-07-30 | 1987-07-29 | Foerfarande foer framstaellning av farmaceutiskt vaerdefullt kristallint (4r,5s,6s,8r,2's,4's)-3-/4-(2-dimetylaminokarbonyl)-pyrrolidinyltio/-4-metyl-6-(1-hydroxietyl)-1-azabicyklo-/3,2,0/-hept-2-en-7-on-2-karboxylsyratrihydrat |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US4888344A (fi) |
| EP (1) | EP0256377B1 (fi) |
| JP (1) | JP2665767B2 (fi) |
| AR (1) | AR243189A1 (fi) |
| AU (1) | AU596857B2 (fi) |
| CA (1) | CA1322371C (fi) |
| DE (1) | DE3781980T2 (fi) |
| DK (1) | DK172666B1 (fi) |
| ES (1) | ES2052524T3 (fi) |
| FI (1) | FI88037C (fi) |
| GR (1) | GR3006254T3 (fi) |
| HK (1) | HK169595A (fi) |
| HU (1) | HU199473B (fi) |
| IE (1) | IE60588B1 (fi) |
| IL (1) | IL83372A (fi) |
| LU (1) | LU88635I2 (fi) |
| MX (1) | MX173359B (fi) |
| NO (2) | NO165543C (fi) |
| NZ (1) | NZ221224A (fi) |
| PH (1) | PH24710A (fi) |
Families Citing this family (63)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1283906C (en) * | 1983-05-09 | 1991-05-07 | Makoto Sunagawa | .beta.-LACTAM COMPOUNDS AND PRODUCTION THEREOF |
| KR880006244A (ko) * | 1986-11-24 | 1988-07-22 | 후지사와 도모 기찌 로 | 3-피롤리디닐티오-1-아자바이스클로[3.2.0]햅트2-엔-2-카르복실산 화합물 및 이의 제조방법 |
| DE69019610D1 (de) * | 1989-07-06 | 1995-06-29 | Banyu Pharma Co Ltd | Cyclische Derivate des Amidinylthiocarbapenems. |
| CA2033390A1 (en) * | 1989-12-29 | 1991-06-30 | Susumu Nakagawa | 2-(2-cyclopropylpyrrolidin-4-ylthio) carbapenem derivatives |
| TW264475B (fi) * | 1991-09-20 | 1995-12-01 | Takeda Pharm Industry Co Ltd | |
| JP2696807B2 (ja) * | 1992-08-06 | 1998-01-14 | 田辺製薬株式会社 | カルバペネム誘導体の製法 |
| GB9503717D0 (en) * | 1995-02-24 | 1995-04-12 | Smithkline Beecham Plc | Novel compounds |
| FR2735474B1 (fr) * | 1995-06-13 | 1997-08-08 | Roussel Uclaf | Chlorhydrate de zilpaterol sous une forme cristallisee particuliere, son procede de preparation et les produits intermediaires mis en oeuvre |
| DE69814381T2 (de) * | 1997-02-07 | 2003-12-04 | Kyoto Pharmaceutical Industries, Ltd. | Carbapenemverbindungen, ihre verwendung und zwischenstufen zu ihrer herstellung |
| CZ292623B6 (cs) | 1998-05-01 | 2003-11-12 | Kyoto Pharmaceutical Industries, Ltd. | Karbapenemové deriváty, antibakteriální činidlo s jejich obsahem a jejich meziproduktové sloučeniny |
| CA2375601C (en) | 1999-06-03 | 2008-07-29 | Eisai Co., Ltd. | Carbapenem compound crystals and injection preparations |
| US7041660B2 (en) | 1999-07-06 | 2006-05-09 | Sankyo Company, Limited | Crystalline 1-methylcarbapenem derivatives |
| TWI250160B (en) | 1999-07-06 | 2006-03-01 | Sankyo Co | Crystalline 1-methylcarbapenem compound |
| AU5984801A (en) * | 2000-05-12 | 2001-11-20 | Novalar Pharmaceuticals Inc | Local anesthetic methods and kits |
| JP5079190B2 (ja) * | 2001-04-27 | 2012-11-21 | 大日本住友製薬株式会社 | アゼチジノン誘導体およびその製造方法 |
| KR20040000466A (ko) * | 2001-05-21 | 2004-01-03 | 교토 야쿠힝 고교 가부시키가이샤 | 카르바페넴 화합물 |
| KR100451672B1 (ko) * | 2001-06-05 | 2004-10-08 | 한미약품 주식회사 | 결정성 세프디니르 산부가염, 이의 제조방법 및 이를이용한 세프디니르의 제조방법 |
| WO2003016312A1 (fr) * | 2001-08-13 | 2003-02-27 | Eisai Co., Ltd. | Procede de preparation d'antibiotiques a base de carbapenem |
| US7145002B2 (en) * | 2001-09-26 | 2006-12-05 | Merck & Co. Inc. | Crystalline forms of carbapenem antibiotics and methods of preparation |
| WO2003027067A2 (en) * | 2001-09-26 | 2003-04-03 | Merck & Co., Inc. | Process for making carbapenem compounds |
| ITMI20012364A1 (it) * | 2001-11-09 | 2003-05-09 | Antibioticos Spa | Processo di sintesi della cefixima via alchil-o arilsolfonati |
| EP1490090A4 (en) | 2002-02-22 | 2006-09-20 | New River Pharmaceuticals Inc | SYSTEMS FOR DELIVERING ACTIVE AGENTS AND METHODS FOR PROTECTING AND DELIVERING ACTIVE AGENTS |
| US20030236306A1 (en) * | 2002-06-20 | 2003-12-25 | Chen Andrew X. | Stabilized formulations of alpha adrenergic receptor antagonists and the uses thereof |
| US7229630B2 (en) * | 2002-06-20 | 2007-06-12 | Novalar Pharmaceuticals, Inc. | Stabilized formulations of alpha adrenergic receptor antagonists and the uses thereof |
| AU2003264406A1 (en) | 2002-09-11 | 2004-04-30 | Michio Ishibashi | Drug or cosmetic |
| WO2005118586A1 (en) * | 2004-06-02 | 2005-12-15 | Sandoz Ag | Meropenem intermediate in crystalline form |
| WO2006035300A2 (en) * | 2004-09-30 | 2006-04-06 | Ranbaxy Laboratories Limited | A process for the preparation of meropenem |
| JP4547245B2 (ja) * | 2004-12-16 | 2010-09-22 | 株式会社パーマケム・アジア | ペリンドプリルエルブミンのｉ型結晶、及びその製造方法 |
| US8501818B2 (en) * | 2005-03-14 | 2013-08-06 | Ceptaris Therapeutics, Inc. | Stabilized compositions of alkylating agents and methods of using same |
| US7872050B2 (en) | 2005-03-14 | 2011-01-18 | Yaupon Therapeutics Inc. | Stabilized compositions of volatile alkylating agents and methods of using thereof |
| US20110039943A1 (en) * | 2005-03-14 | 2011-02-17 | Robert Alonso | Methods for treating skin disorders with topical nitrogen mustard compositions |
| US20070197781A1 (en) * | 2005-07-29 | 2007-08-23 | Neera Tewari | Processes for the preparation of carbapenems |
| PL1926732T3 (pl) | 2005-09-05 | 2014-01-31 | Ranbaxy Laboratories Ltd | Sposób wytwarzania związków karbapenemu |
| BRPI0616563A2 (pt) | 2005-09-15 | 2012-12-25 | Orchid Chemicals & Pharm Ltd | processo melhorado para a preparaÇço de antibiàtico betalactÂmico |
| CN100497338C (zh) * | 2006-01-05 | 2009-06-10 | 上海医药工业研究院 | 4－甲基－7－氧－1－氮杂双环[3.2.0]庚－2－烯－2－羧酸类衍生物的制备方法 |
| KR100781821B1 (ko) * | 2006-02-16 | 2007-12-03 | 문순구 | 카르바페넴계 화합물의 제조방법 |
| TW200801004A (en) * | 2006-03-28 | 2008-01-01 | Kaneka Corp | Improved process for producing carbapenem compound |
| US8093378B2 (en) * | 2006-04-28 | 2012-01-10 | Kaneka Corporation | Crystallization method for intermediates of carbapenem antibiotics |
| WO2009075309A1 (ja) * | 2007-12-12 | 2009-06-18 | Dainippon Sumitomo Pharma Co., Ltd. | 製剤組成物 |
| US20090216010A1 (en) * | 2008-02-22 | 2009-08-27 | Wei-Hong Tseng | Crystalline carbapenem compound and produced method thereof |
| EP2098525A1 (en) | 2008-02-26 | 2009-09-09 | Savior Lifetec Corporation | Crystalline carbapenem compound and produced method thereof |
| ES2727523T3 (es) * | 2008-03-27 | 2019-10-16 | Helsinn Healthcare Sa | Composiciones estabilizadas de agentes de alquilación y métodos de utilización de estas composiciones |
| US8097719B2 (en) * | 2008-07-15 | 2012-01-17 | Genesen Labs | Meropenem intermediate in novel crystalline form and a method of manufacture of meropenem |
| KR20110049823A (ko) * | 2008-07-30 | 2011-05-12 | 랜박시 래보러터리스 리미티드 | 카르바페넴 화합물의 제조 방법 |
| WO2010104336A2 (ko) * | 2009-03-13 | 2010-09-16 | 주식회사 대웅제약 | 아연 분말을 이용한 메로페넴의 개선된 제조방법 |
| WO2011048583A1 (en) | 2009-10-23 | 2011-04-28 | Ranbaxy Laboratories Limited | Process for the preparation of carbapenem compounds |
| WO2011141847A1 (en) * | 2010-05-10 | 2011-11-17 | Orchid Chemicals And Pharmaceuticals Limited | An improved process for the preparation of meropenem |
| PL2630147T3 (pl) | 2010-10-22 | 2015-08-31 | Ranbaxy Laboratories Ltd | Sposób otrzymywania czystego trihydratu meropenemu |
| CN101962383A (zh) * | 2010-11-12 | 2011-02-02 | 上海巴迪生物医药科技有限公司 | 一种美罗培南的合成方法 |
| WO2012081033A2 (en) * | 2010-12-06 | 2012-06-21 | Sequent Scientific Limited | A process for preparation of imipenem |
| CN102532140B (zh) * | 2010-12-21 | 2015-03-11 | 北大方正集团有限公司 | 一种美罗培南三水合物的制备方法 |
| CN102250096B (zh) * | 2011-09-05 | 2016-04-06 | 江西华邦药业有限公司 | 一种美罗培南的制备方法 |
| CN103570719B (zh) * | 2012-07-31 | 2016-03-02 | 深圳市海滨制药有限公司 | 一种美罗培南原料药、其制备方法及包含其的药物组合物 |
| CN103570718B (zh) * | 2012-07-31 | 2016-06-29 | 深圳市海滨制药有限公司 | 一种美罗培南原料药、其制备方法及包含其的药物组合物 |
| CN103570720B (zh) * | 2012-07-31 | 2016-02-10 | 新乡海滨药业有限公司 | 一种美罗培南原料药、其制备方法及包含其的药物组合物 |
| KR101331762B1 (ko) | 2012-12-28 | 2013-11-20 | 주식회사 대웅제약 | 메로페넴의 삼수화물의 제조방법 |
| CN103044429B (zh) * | 2013-01-28 | 2015-04-01 | 苏州二叶制药有限公司 | 一种美罗培南的制备方法 |
| JP6436354B2 (ja) | 2013-02-01 | 2018-12-12 | オキュフィア・ファーマ・インコーポレイテッドＯｃｕｐｈｉｒｅ Ｐｈａｒｍａ， Ｉｎｃ． | 視機能を改善するためのフェントラミンの連日眼科投与のための方法および組成物 |
| CA2899339C (en) | 2013-02-01 | 2021-07-06 | Ocularis Pharma, Llc | Aqueous ophthalmic solutions of phentolamine and medical uses thereof |
| KR102144777B1 (ko) | 2013-06-19 | 2020-08-18 | 제이더블유중외제약 주식회사 | 결정형 메로페넴 삼수화물의 제조방법 |
| CN106459052B (zh) | 2014-03-27 | 2021-07-30 | 庄信万丰股份有限公司 | 制备碳青霉烯抗生素的方法 |
| EP3870170A4 (en) | 2018-10-26 | 2022-07-20 | Ocuphire Pharma, Inc. | METHODS AND COMPOSITIONS FOR THE TREATMENT OF PRESBYOPIA, MYDRIASIS AND OTHER EYE DISEASES |
| CN115368310A (zh) | 2021-05-18 | 2022-11-22 | 奥库菲尔医药公司 | 合成甲磺酸酚妥拉明的方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK153486C (da) * | 1978-07-03 | 1988-11-28 | Merck & Co Inc | Analogifremgangsmaade til fremstilling af krystallinsk n-formimidoyl-thienamycin-monohydrat |
| EP0113101A1 (en) * | 1982-12-30 | 1984-07-11 | Merck & Co. Inc. | 6-(1-Hydroxyethyl)-2-SR8-1-methyl-1-carbadethiapen-2-em-3-carboxylic acid esters |
| JPS60104088A (ja) * | 1983-11-11 | 1985-06-08 | Sumitomo Chem Co Ltd | 新規なβ−ラクタム化合物およびその製造法 |
| CA1283906C (en) * | 1983-05-09 | 1991-05-07 | Makoto Sunagawa | .beta.-LACTAM COMPOUNDS AND PRODUCTION THEREOF |
| US4748238A (en) * | 1984-03-14 | 1988-05-31 | Merck & Co., Inc. | Crystalline 1R,5S,6S,8R-1-methyl-2-(N,N-dimethylcarbamimidoylmethylthio)-6-(1-hydroxyethyl)-1-carbapen-2-em-3-carboxylic acid |
| US4713451A (en) * | 1984-04-09 | 1987-12-15 | Merck & Co., Inc. | Crystalline dimethyliminothienamycin |
| US4761408A (en) * | 1984-11-02 | 1988-08-02 | Ciba-Geigy Corporation | Crystalline aminomethyl compound |
| NZ214691A (en) * | 1984-12-27 | 1988-08-30 | Sumitomo Pharma | The preparation of carbapenem derivatives and beta-lactam intermediates |
| US4788282A (en) * | 1985-06-07 | 1988-11-29 | Bristol-Myers Company | Deprotection of allylic esters and ethers |
-
1987
- 1987-07-20 IE IE195987A patent/IE60588B1/en not_active IP Right Cessation
- 1987-07-28 NZ NZ221224A patent/NZ221224A/xx unknown
- 1987-07-28 AU AU76196/87A patent/AU596857B2/en not_active Expired
- 1987-07-29 LU LU88635C patent/LU88635I2/fr unknown
- 1987-07-29 ES ES87110992T patent/ES2052524T3/es not_active Expired - Lifetime
- 1987-07-29 CA CA000543276A patent/CA1322371C/en not_active Expired - Lifetime
- 1987-07-29 DE DE8787110992T patent/DE3781980T2/de not_active Expired - Lifetime
- 1987-07-29 PH PH35599A patent/PH24710A/en unknown
- 1987-07-29 FI FI873299A patent/FI88037C/fi not_active IP Right Cessation
- 1987-07-29 IL IL83372A patent/IL83372A/xx not_active IP Right Cessation
- 1987-07-29 EP EP87110992A patent/EP0256377B1/en not_active Expired - Lifetime
- 1987-07-30 DK DK198703990A patent/DK172666B1/da not_active IP Right Cessation
- 1987-07-30 US US07/079,470 patent/US4888344A/en not_active Expired - Lifetime
- 1987-07-30 AR AR87308307A patent/AR243189A1/es active
- 1987-07-30 HU HU873521A patent/HU199473B/hu unknown
- 1987-07-30 MX MX753487A patent/MX173359B/es unknown
- 1987-07-30 NO NO873205A patent/NO165543C/no not_active IP Right Cessation
-
1988
- 1988-05-16 JP JP63117078A patent/JP2665767B2/ja not_active Expired - Lifetime
-
1992
- 1992-11-16 GR GR920402593T patent/GR3006254T3/el unknown
-
1995
- 1995-11-02 HK HK169595A patent/HK169595A/xx not_active IP Right Cessation
-
1997
- 1997-10-17 NO NO1997013C patent/NO1997013I1/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| GR3006254T3 (fi) | 1993-06-21 |
| AU596857B2 (en) | 1990-05-17 |
| JPS6434986A (en) | 1989-02-06 |
| MX7534A (es) | 1993-10-01 |
| NO165543C (no) | 1991-02-27 |
| AU7619687A (en) | 1988-03-03 |
| NO165543B (no) | 1990-11-19 |
| NZ221224A (en) | 1989-10-27 |
| NO873205D0 (no) | 1987-07-30 |
| DE3781980T2 (de) | 1993-02-18 |
| EP0256377A1 (en) | 1988-02-24 |
| ES2052524T3 (es) | 1994-07-16 |
| LU88635I2 (fr) | 1995-12-01 |
| HK169595A (en) | 1995-11-10 |
| DE3781980D1 (de) | 1992-11-05 |
| NO1997013I1 (no) | 1997-10-17 |
| CA1322371C (en) | 1993-09-21 |
| IE60588B1 (en) | 1994-07-27 |
| DK399087D0 (da) | 1987-07-30 |
| NO873205L (no) | 1988-02-01 |
| US4888344A (en) | 1989-12-19 |
| JP2665767B2 (ja) | 1997-10-22 |
| HU199473B (en) | 1990-02-28 |
| EP0256377B1 (en) | 1992-09-30 |
| IE871959L (en) | 1988-01-30 |
| HUT44553A (en) | 1988-03-28 |
| FI873299A0 (fi) | 1987-07-29 |
| IL83372A (en) | 1992-05-25 |
| IL83372A0 (en) | 1987-12-31 |
| MX173359B (es) | 1994-02-23 |
| AR243189A1 (es) | 1993-07-30 |
| PH24710A (en) | 1990-10-01 |
| DK399087A (da) | 1988-01-31 |
| FI873299A (fi) | 1988-01-31 |
| FI88037C (fi) | 1993-03-25 |
| DK172666B1 (da) | 1999-05-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| FI88037B (fi) | Foerfarande foer framstaellning av farmaceutiskt vaerdefullt kristallint (4r,5s,6s,8r,2's,4's)-3-/4-(2-dimetylaminokarbonyl)-pyrrolidinyltio/-4-metyl-6-(1-hydroxietyl)-1-azabicyklo-/3,2,0/-hept-2-en-7-on-2-karboxylsyratrihydrat | |
| NO179639C (no) | Analogifremgangsmåte for fremstilling av terapeutisk aktive, substituerte piperidinforbindelser | |
| NO177387C (no) | Analogifremgangsmåte for fremstilling av terapeutisk aktive imidazo-kondenserte, 6-leddede, heterocykliske forbindelser | |
| AU590403B2 (en) | Pharmaceutical composition for the treatment of periodontal diseases | |
| NO174239C (no) | Fremgangsmåte for fremstilling av et oralt, farmasöytisk preparat | |
| NO871408L (no) | Forbedringer ved farmasoeytiske akseptable salter. | |
| IT1235532B (it) | Composti carbossiammidici, procedimenti per la preparazione dei medesimi e composizione farmaceutica contenente i medesimi | |
| DK53285A (da) | (-)-trans-4(4-fluorphenyl)-3-(4-methoxyphenoxy)-methylpiperidin, farmaceutisk acceptable syreadditionssalte heraf og farmaceutisk praeparat indeholdende samme | |
| NO170330C (no) | Fremgangsmaate for fremstilling av vesentlig optisk rent monohydrat av s-(-)-propyl-2',6'-pipekoloksylididhydroklorid | |
| NO171909C (no) | Analogifremgangsmaate for fremstilling av terapeutisk aktive 1,4-dihydropyridinderivater | |
| DK144685A (da) | Substituerede benzopyraner, fremgangsmaader til fremstilling deraf samt deres anvendelse i laegemidler | |
| FI871087A0 (fi) | Menetelmä terapeuttisesti aktiivisten 1,2,3,4-tetrahydro-3-karbamoyyli-2-tiokso/okso-5-pyrimidiinikarboksyylihappojohdannaisten valmistamiseksi | |
| PT84923A (en) | Process for the preparation of 1-(hydroxystyrul)-5h-2,3-benzodiapezine derivatives and pharmaceutical compositions containing the same | |
| IL83194A0 (en) | Beta-lactam compound,method for preparing the same,medicinal composition containing the same for infectious bacterial disease therapy and intermediates for synthesis of the same | |
| NO175976C (no) | Analogifremgangsmåte for fremstilling av terapeutisk aktive 4-(1,6-dihydro-6-okso-pyridazinyl-3-oksy)-3-kromanolderivater | |
| AU7080587A (en) | Therapeutic compositions for veterinary use | |
| DE3361609D1 (en) | New n-((2-oxo-1-pyrrolidinyl)acetyl)piperazines, the methods of producing such new compounds and their salts as well as pharmaceutical preparations for therapeutic use containing these compounds or salts | |
| PT91612A (pt) | Process for the preparation pf 2-aza-4(alkoxycarbonyl> spiro<4,5> decan-3-on and of his own acid derivative 1-(aminomethyl)-cyclo-hexane-acetic | |
| NO881884L (no) | Fremgangsmaate for fremstilling av terapeutisk aktive pyrrolidin-derivater. | |
| AU569516B2 (en) | Galenic forms of sulpiride for oral use | |
| EP0256507A3 (en) | 3-(1h-tetrazol-5-yl)oxanilic acid and salts thereof, method for preparing the same and pharmaceutical compositions containing the compound | |
| AR243159A1 (es) | Procedimiento de preparacion de acido 1-(3-mercapto-(2s)-metilpropionil)-pirrolidin-(2s)-carboxilico o sus sales farmaceuticamente aceptables. | |
| NO171499C (no) | Analogifremgangsmaate for fremstilling av terapeutisk aktive 5,6-dihydro-4h-cyklo-penta(b)tiofen-6-karboksylsyre-derivater | |
| FI89595B (fi) | Foerfarande foer framstaellning av terapeutiskt aktiva 2-(tioalkylamino)etyl-1H-imidazolderivat | |
| FI894813A (fi) | Menetelmä terapeuttisesti aktiivisten 2-metoksikarbonyylisubstituoitujen N,N'-di(trimetoksibentsoyyli)piperatsiinijohdannaisten valmistamiseksi |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ND | Supplementary protection certificate (spc) granted | ||
| SPCG | Supplementary protection certificate granted |
Spc suppl protection certif: L57 Extension date: 20090817 |
|
| FG | Patent granted |
Owner name: SUMITOMO PHARMACEUTICALS COMPANY |
|
| PC | Transfer of assignment of patent |
Owner name: DAINIPPON SUMITOMO PHARMA CO., LTD. Free format text: DAINIPPON SUMITOMO PHARMA CO., LTD. |
|
| MA | Patent expired |