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FI112213B - Förfarande för framställning av terapeutiskt användbara trifluormetylmerkaptan- och merkaptoacylderivat - Google Patents

Förfarande för framställning av terapeutiskt användbara trifluormetylmerkaptan- och merkaptoacylderivat Download PDF

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Publication number
FI112213B
FI112213B FI911399A FI911399A FI112213B FI 112213 B FI112213 B FI 112213B FI 911399 A FI911399 A FI 911399A FI 911399 A FI911399 A FI 911399A FI 112213 B FI112213 B FI 112213B
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Finland
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ethyl acetate
mmol
give
mixture
product
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FI911399A
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English (en)
Finnish (fi)
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FI911399A (fi
FI911399A0 (fi
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George C Rovnyak
Norma G Delaney
Melanie Loots
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Squibb & Sons Inc
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    • C07C319/02—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of thiols
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    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
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    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
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    • C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
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    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/59—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with at least one of the bonds being to sulfur
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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Claims (7)

1. Förfarande för framställning av terapeutiskt användbara trifluormetylmerkaptan- och merkaptoacylderivat 5 med formeln CF3 <ch2)„o (I) II R3 S—CH2 —CH-C-NH-X * väri X är Ri - CH - (CH2) p - COOH, - (CH2) a - COOH, - (CH2)2-(Q Λ""0H' - (CH2)2 -tetrazolyl, -CH-tetrazolyl, -CH-tetrazolyl, lägre alkyl CH2-indolyl eller CHä 0 T il O - CH - C - N-(— COOH; ·: Htw . j Ri är lägre alkyl, - CH2—({3) ' -CH2~tetrazolyl - - CHi—O ' ΌΗ -CH2 - COOH eller 10 f t - CH2-indolyl; » n är 0 eller 1; p är 0 eller 1; och
15 R3 är väte eller lägre-alkyl-C(0)-; * * » kännetecknat av att en syraklorid med formeln 95 112213 CF3 (CH2)n
5 I R3 S—CH2—CH— CO-Cl väri R3 och n är definierade ovan, förbinds till en ami-nomellanprodukt med formeIn 10 h2n-x väri X är definierad ovan, eller till ett vätekloridsalt därav och eventuellt, när R3 är lägre-alkyl-C(0)-, behand-15 las den erhällna produkten med en bas, varvid en produkt enligt formeln I, väri R3 är väte, erhälls.
2. Förfarande enligt patentkrav 1 för fram-ställning av sädana föreningar enligt formeln I, väri n är noll, R3 är väte och X är 20 : β f f3 : —CH—COOH , _£K—COOH , .··: 25 H (Nyo) — CH— COOH , -(CH2)2 COOH , Λ: .ch(ch3)2 ^cooh ( ( : ... —CH COOH , —CH COOH , 35 96 112213 j@8) h 4. n-n — CH-COOH t — CH-COOH , , /¾ / II r N-N 10 — (CK2)2-\ I! eller—CT ( N-N ^ n-n kännetecknat av att en syraklorid med formeln 0 cf3 0 is II I 11 h3c— c— s— ch2—CH— c— Cl kopplas med en aminomellanprodukt med formeln
20 H2N-X ' väri X är definierad ovan, eller med ett hydrokloridsalt ·* · därav, och den erhällna produkten behandlas med en bas. » ·
FI911399A 1990-03-22 1991-03-22 Förfarande för framställning av terapeutiskt användbara trifluormetylmerkaptan- och merkaptoacylderivat FI112213B (sv)

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Application Number Priority Date Filing Date Title
US49738690A 1990-03-22 1990-03-22
US49738690 1990-03-22
SG165394 1994-11-16
SG165394A SG165394G (en) 1990-03-22 1994-11-16 Mercapto-or acylthio-trifluoromethyl amide derivatives and their use

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FI911399A0 FI911399A0 (fi) 1991-03-22
FI911399A FI911399A (fi) 1991-09-23
FI112213B true FI112213B (sv) 2003-11-14

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CN (1) CN1038505C (sv)
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IT1273455B (it) * 1995-01-27 1997-07-08 Zambon Spa Derivati tiolici ad attivita' inibitrice delle metallopeptidasi
IT1277736B1 (it) * 1995-12-28 1997-11-12 Zambon Spa Derivati tiolici ad attivita' inibitrice delle metallopeptidasi
FR2805259B1 (fr) * 2000-02-17 2002-03-29 Inst Nat Sante Rech Med Nouveaux derives d'aminoacides n-mercaptoacyles, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
TW200519106A (en) 2003-05-02 2005-06-16 Novartis Ag Organic compounds

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SE429374B (sv) * 1980-04-15 1983-08-29 Luxor Ab Feste
FR2480747A1 (fr) * 1980-04-17 1981-10-23 Roques Bernard Derives d'acides amines et leur application therapeutique
US4333943A (en) * 1980-04-24 1982-06-08 Miles Laboratories, Inc. Ethyl 3-(3-indolyl)-3-(5-tetrazolyl) propionate compounds used as anti-hypertensive agents
BE890948A (fr) * 1981-10-30 1982-02-15 Luitpold Werk Chem Pharm Derives de l'acide anthranilique
EP0361365A1 (en) * 1988-09-30 1990-04-04 E.R. SQUIBB &amp; SONS, INC. Aminobenzoic and aminocyclohexane-carboylic acid compounds, compositions, and their method of use

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KR0184876B1 (ko) 1999-05-15
FI911399A (fi) 1991-09-23
DE69103454T2 (de) 1995-03-16
SK279617B6 (sk) 1999-01-11
HU210313B (en) 1995-07-28
CY1820A (en) 1995-10-20
AU7367291A (en) 1991-10-03
JPH04234842A (ja) 1992-08-24
KR910016693A (ko) 1991-11-05
PT97121A (pt) 1991-11-29
RU2024504C1 (ru) 1994-12-15
EG19711A (en) 1995-09-30
HUT57186A (en) 1991-11-28
DK0449523T3 (da) 1994-09-19
EP0449523A1 (en) 1991-10-02
NO175147B (no) 1994-05-30
IE65539B1 (en) 1995-11-01
NO911149D0 (no) 1991-03-21
AU632408B2 (en) 1992-12-24
CA2038379A1 (en) 1991-09-23
MX25035A (es) 1994-01-31
ZA912133B (en) 1991-12-24
NO911149L (no) 1991-09-23
FI911399A0 (fi) 1991-03-22
CN1038505C (zh) 1998-05-27
PL165153B1 (pl) 1994-11-30
PT97121B (pt) 1998-08-31
IL97626A (en) 1995-08-31
ES2057761T3 (es) 1994-10-16
NZ237534A (en) 1992-09-25
HU910956D0 (en) 1991-10-28
JP2955051B2 (ja) 1999-10-04
DE69103454D1 (de) 1994-09-22
IL97626A0 (en) 1992-06-21
NO175147C (no) 1994-09-07
PL289549A1 (en) 1991-10-21
CS9100765A2 (en) 1991-10-15
CZ281165B6 (cs) 1996-07-17
CN1055735A (zh) 1991-10-30
CA2038379C (en) 2002-11-05
HK24295A (en) 1995-03-03
EP0449523B1 (en) 1994-08-17
ATE110056T1 (de) 1994-09-15
IE910941A1 (en) 1991-09-25
SG165394G (en) 1995-04-28

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