ES8604422A1 - Un procedimiento para obtener una vacuna de coronavirus canino - Google Patents
Un procedimiento para obtener una vacuna de coronavirus caninoInfo
- Publication number
- ES8604422A1 ES8604422A1 ES538588A ES538588A ES8604422A1 ES 8604422 A1 ES8604422 A1 ES 8604422A1 ES 538588 A ES538588 A ES 538588A ES 538588 A ES538588 A ES 538588A ES 8604422 A1 ES8604422 A1 ES 8604422A1
- Authority
- ES
- Spain
- Prior art keywords
- canine
- coronavirus
- vaccine
- virus
- avirulent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/215—Coronaviridae, e.g. avian infectious bronchitis virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5252—Virus inactivated (killed)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5254—Virus avirulent or attenuated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
- A61K2039/552—Veterinary vaccine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55516—Proteins; Peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/70—Multivalent vaccine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14311—Parvovirus, e.g. minute virus of mice
- C12N2750/14334—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18411—Morbillivirus, e.g. Measles virus, canine distemper
- C12N2760/18434—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18611—Respirovirus, e.g. Bovine, human parainfluenza 1,3
- C12N2760/18634—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/20011—Coronaviridae
- C12N2770/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S424/00—Drug, bio-affecting and body treating compositions
- Y10S424/818—Viral vaccine for canidae or mustelidae, e.g. dogs, foxes, minks
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Communicable Diseases (AREA)
- Pulmonology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
METODO DE PRODUCCION DE VACUNAS DE CORONAVIRUS CANINO. COMPRENDE LA INOCULACION DE UNA SUSPENSION DE CULTIVO CELULAR DE TEJIDO DE MAMIFERO CON CORONAVIRUS CANINO; COSECHAR ESTAS CEKULAS DESPUES DE UN TIEMPO DE 24 A 96 HORAS DESDE LA INOCULACION, SEPARANDO LA MONOCAPA DE CELULAS MEDIANTE CONGELACION-DESCONGELACION POR ACCION ENZIMATICA PARA AUMENTAR EL CONTENIDO VIRAL DE LOS FLUIDOS COSECHADOS; RECOGER EL VIRUS PROPAGADO DE LAS CELULAS COSECHADAS; INACTIVAR DICHO VIRUS MEDIANTE AGENTES INACTIVANTES, COMO BETA-PROPIOLACTONA AL 0,01-0,5%, ADICIONADO A FLUIDO DE VIRUS CONTENIDO EN LOS RECIPIENTES DE PROPAGACION, Y CONTROL DEL PH MEDIANTE HIDROXIDO SODICO O BICARBONATO SODICO; Y ADICIONAR UN COADYUVANTE O MEZCLAS DE ESTOS A LA COMPOSICION INACTIVADA. ESTAS VACUNAS TIENEN APLICACIONES PARA EL TRATAMIENTO DE INFECCIONES EN PERROS.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/504,434 US4567043A (en) | 1983-06-15 | 1983-06-15 | Canine corona virus vaccine |
US06/618,638 US4567042A (en) | 1983-06-15 | 1984-06-07 | Inactivated canine coronavirus vaccine |
EP84902632A EP0145783B2 (en) | 1983-06-15 | 1984-06-14 | Canine coronavirus vaccine |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8604422A1 true ES8604422A1 (es) | 1986-02-01 |
ES538588A0 ES538588A0 (es) | 1986-02-01 |
Family
ID=27054825
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES538588A Expired ES8604422A1 (es) | 1983-06-15 | 1984-12-14 | Un procedimiento para obtener una vacuna de coronavirus canino |
Country Status (7)
Country | Link |
---|---|
US (1) | US4567042A (es) |
EP (4) | EP0345911B1 (es) |
AT (4) | ATE280217T1 (es) |
DE (4) | DE3486293T3 (es) |
ES (1) | ES8604422A1 (es) |
NL (1) | NL940017I2 (es) |
WO (1) | WO1985000014A1 (es) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4990367A (en) * | 1987-03-09 | 1991-02-05 | Diamond Scientific Company | Canine distemper virus vaccine |
ES2052685T3 (es) * | 1987-03-17 | 1994-07-16 | Akzo Nv | Metodo para producir un adyuvante libre. |
US5565209A (en) * | 1987-03-17 | 1996-10-15 | Akzo Nobel N.V. | Adjuvant mixture |
US4904468A (en) * | 1987-06-08 | 1990-02-27 | Norden Laboratories, Inc. | Canine coronavirus vaccine |
US5911999A (en) * | 1987-09-28 | 1999-06-15 | Pfizer, Inc. | Vaccine based on TGEV for protection of dogs against canine coronavirus |
US5232694A (en) * | 1989-05-03 | 1993-08-03 | Akzo N.V. | Canine corona virus vaccine |
US5672350A (en) * | 1989-08-22 | 1997-09-30 | Veterinary Infectious Disease Organization | Recombinant bovine coronavirus E2 and E3 polypeptides and vaccines |
US6004563A (en) * | 1990-11-07 | 1999-12-21 | American Home Products Corporation | Feline vaccine compositions and method for preventing chlamydia infections or diseases using the same |
US6372224B1 (en) | 1990-11-14 | 2002-04-16 | Pfizer Inc. | Canine coronavirus S gene and uses therefor |
US6057436A (en) * | 1990-11-14 | 2000-05-02 | Pfizer Inc. | Canine coronavirus S gene and uses therefor |
DE69233270T2 (de) * | 1991-04-25 | 2004-09-30 | Akzo Nobel N.V. | Subeinheits-Impfstoff gegen Hundecoronavirus |
US5750112A (en) * | 1993-02-26 | 1998-05-12 | Solvay Animal Health, Inc. | Canine coronavirus vaccine from feline enteric coronavirus |
US20040048235A1 (en) * | 1995-08-29 | 2004-03-11 | V.I. Technologies, Inc. | Methods and compositions for the selective modification of nucleic acids |
US20040053208A1 (en) * | 1995-08-29 | 2004-03-18 | V. I. TECHNOLOGIES, Inc. | Methods to selectively inactivate parasites in biological compositions |
GB9622159D0 (en) * | 1996-10-24 | 1996-12-18 | Solvay Sociutu Anonyme | Polyanionic polymers as adjuvants for mucosal immunization |
US6093564A (en) | 1997-10-03 | 2000-07-25 | V.I. Technologies, Inc. | Methods and compositions for the selective modification of nucleic acids |
US6369048B1 (en) | 1998-01-12 | 2002-04-09 | V.I. Technologies, Inc. | Methods and compositions for inactivating viruses |
FR2775601B1 (fr) | 1998-03-03 | 2001-09-21 | Merial Sas | Vaccins vivants recombines et adjuves |
US6617100B2 (en) | 1998-09-25 | 2003-09-09 | V.I. Technologies, Inc. | Solid phase quenching systems |
US6150109A (en) | 1999-01-25 | 2000-11-21 | V. I. TECHNOLOGIES, Inc. | Lipophilic quenching of viral inactivating agents |
US20020131958A1 (en) * | 2001-01-22 | 2002-09-19 | John Chapman | Method for purifying a biological composition |
US20030129161A1 (en) * | 2001-09-17 | 2003-07-10 | Hsien-Jue Chu | Interleukin-12 as a veterinary vaccine adjuvant |
US7790178B2 (en) | 2002-12-19 | 2010-09-07 | Intervet International B.V. | Trivalent vaccine with maternal anitbody transfer via the milk |
US20050089533A1 (en) * | 2003-01-29 | 2005-04-28 | Joseph Frantz | Canine vaccines against Bordetella bronchiseptica |
CN1835767A (zh) * | 2003-01-29 | 2006-09-20 | 辉瑞产品公司 | 对抗支气管败血性博德特氏杆菌的犬疫苗 |
US9023366B2 (en) | 2003-07-01 | 2015-05-05 | The Royal Veterinary College | Vaccine composition for vaccinating dogs against canine infectious respiratory disease (CIRD) |
GB0315323D0 (en) * | 2003-07-01 | 2003-08-06 | Royal Veterinary College | Vaccine composition |
JP2007508837A (ja) * | 2003-10-23 | 2007-04-12 | ファイザー・プロダクツ・インク | 歯周疾患のためのワクチン |
EP1871410A2 (en) * | 2005-04-07 | 2008-01-02 | Pharmacia & Upjohn Company LLC | Formulations and process for production of bordetella bronchiseptica p68 antigen and vaccines |
PT1780216E (pt) * | 2005-10-26 | 2011-02-03 | Canio Buonavoglia | Coronavírus canino pantrópico |
US7682619B2 (en) * | 2006-04-06 | 2010-03-23 | Cornell Research Foundation, Inc. | Canine influenza virus |
KR101013226B1 (ko) * | 2008-05-14 | 2011-02-10 | 녹십자수의약품(주) | 개 바이러스성 설사병 예방용 백신 |
US20110110980A1 (en) * | 2009-09-02 | 2011-05-12 | Wyeth Llc | Heterlogous prime-boost immunization regimen |
UY34745A (es) | 2012-04-18 | 2013-11-29 | Zoetis Llc | Vacunas y procedimientos para tratar la enfermedad de lyme en perros |
US20140170180A1 (en) | 2012-12-17 | 2014-06-19 | Boehringer Ingelheim Vetmedica, Inc. | Porcine parvovirus 5a, methods of use and vaccine |
US20140234354A1 (en) | 2013-02-15 | 2014-08-21 | Boehringer Ingelheim Vetmedica, Inc. | Porcine parvovirus 5b, methods of use and vaccine |
US9579373B2 (en) | 2013-03-15 | 2017-02-28 | Boehringer Ingelheim Vetmedica, Inc. | Porcine reproductive and respiratory syndrome virus, compositions, vaccine and methods of use |
WO2019092027A1 (en) | 2017-11-09 | 2019-05-16 | Boehringer Ingelheim Vetmedica Gmbh | Sapelovirus immunogenic compositions and uses thereof |
WO2020142778A1 (en) | 2019-01-04 | 2020-07-09 | Boehringer Ingelheim Animal Health USA Inc. | Attenuated bordetella bronchiseptica strains, oral vaccines containing the attenuated strains, and methods of making & use thereof |
CN109765384B (zh) * | 2019-01-29 | 2022-11-18 | 北京勤邦生物技术有限公司 | 一种犬冠状病毒抗体荧光检测试纸条及其制备方法和应用 |
CN112402599B (zh) * | 2019-08-23 | 2023-06-27 | 中国农业科学院特产研究所 | 一种犬用犬瘟热、细小病毒病二联灭活疫苗及其制备方法 |
JPWO2022149342A1 (es) * | 2021-01-06 | 2022-07-14 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3143474A (en) * | 1962-07-30 | 1964-08-04 | Sterling Drug Inc | Preparation of duck-embryo modified infectious canine hepatitis virus vaccine |
US3704203A (en) † | 1967-08-24 | 1972-11-28 | Diamond Lab Inc | Transmissible gastroenteritis vaccines and methods of producing the same |
US3652761A (en) * | 1969-09-04 | 1972-03-28 | Corning Glass Works | Immunochemical composites and antigen or antibody purification therewith |
US3959251A (en) * | 1970-06-25 | 1976-05-25 | Exploaterings Aktiebolaget T.B.F. | Stabilized agar product and method for its stabilization |
-
1984
- 1984-06-07 US US06/618,638 patent/US4567042A/en not_active Expired - Lifetime
- 1984-06-14 DE DE3486293T patent/DE3486293T3/de not_active Expired - Lifetime
- 1984-06-14 AT AT89201996T patent/ATE280217T1/de not_active IP Right Cessation
- 1984-06-14 DE DE3486292T patent/DE3486292T2/de not_active Expired - Lifetime
- 1984-06-14 DE DE8484902632T patent/DE3481582D1/de not_active Expired - Lifetime
- 1984-06-14 EP EP19890201996 patent/EP0345911B1/en not_active Expired - Lifetime
- 1984-06-14 AT AT84902632T patent/ATE50913T1/de not_active IP Right Cessation
- 1984-06-14 EP EP84902632A patent/EP0145783B2/en not_active Expired - Lifetime
- 1984-06-14 DE DE3486495T patent/DE3486495D1/de not_active Expired - Lifetime
- 1984-06-14 EP EP89202001A patent/EP0344872B2/en not_active Expired - Lifetime
- 1984-06-14 WO PCT/US1984/000904 patent/WO1985000014A1/en active IP Right Grant
- 1984-06-14 EP EP19890201017 patent/EP0329264B1/en not_active Expired - Lifetime
- 1984-12-14 ES ES538588A patent/ES8604422A1/es not_active Expired
-
1989
- 1989-04-20 AT AT89201017T patent/ATE103181T1/de not_active IP Right Cessation
- 1989-07-31 AT AT89202001T patent/ATE103180T1/de not_active IP Right Cessation
-
1994
- 1994-08-18 NL NL940017C patent/NL940017I2/nl unknown
Also Published As
Publication number | Publication date |
---|---|
EP0145783A1 (en) | 1985-06-26 |
DE3481582D1 (de) | 1990-04-19 |
EP0329264B1 (en) | 1994-03-23 |
EP0145783B1 (en) | 1990-03-14 |
ATE103180T1 (de) | 1994-04-15 |
EP0345911B1 (en) | 2004-10-20 |
NL940017I2 (nl) | 2001-02-01 |
DE3486293T2 (de) | 1994-06-30 |
NL940017I1 (nl) | 1994-10-17 |
DE3486292T2 (de) | 1994-06-30 |
ATE103181T1 (de) | 1994-04-15 |
DE3486293T3 (de) | 2002-11-21 |
EP0344872B1 (en) | 1994-03-23 |
WO1985000014A1 (en) | 1985-01-03 |
ATE50913T1 (de) | 1990-03-15 |
DE3486293D1 (de) | 1994-04-28 |
EP0329264A2 (en) | 1989-08-23 |
EP0145783A4 (en) | 1985-10-14 |
EP0329264A3 (en) | 1989-12-13 |
EP0345911A1 (en) | 1989-12-13 |
US4567042A (en) | 1986-01-28 |
ATE280217T1 (de) | 2004-11-15 |
EP0145783B2 (en) | 2004-01-02 |
DE3486293T4 (de) | 1995-06-14 |
DE3486292D1 (de) | 1994-04-28 |
ES538588A0 (es) | 1986-02-01 |
EP0344872A1 (en) | 1989-12-06 |
DE3486495D1 (de) | 2004-11-25 |
EP0344872B2 (en) | 2002-04-24 |
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