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ES8301958A1 - Procedimiento de preparar benzopiranos 7-substituidos - Google Patents

Procedimiento de preparar benzopiranos 7-substituidos

Info

Publication number
ES8301958A1
ES8301958A1 ES504419A ES504419A ES8301958A1 ES 8301958 A1 ES8301958 A1 ES 8301958A1 ES 504419 A ES504419 A ES 504419A ES 504419 A ES504419 A ES 504419A ES 8301958 A1 ES8301958 A1 ES 8301958A1
Authority
ES
Spain
Prior art keywords
hydrogen
alkyl
represent
carbon atoms
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES504419A
Other languages
English (en)
Other versions
ES504419A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chinoin Private Co Ltd
Original Assignee
Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt filed Critical Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt
Publication of ES8301958A1 publication Critical patent/ES8301958A1/es
Publication of ES504419A0 publication Critical patent/ES504419A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/60—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with aryl radicals attached in position 2

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE BEZOPIRANOS 7-SUSTITUIDOS Y SIMILARES, RACEMICOS Y OPTICAMENTE ACTIVOS, Y DE SUS SALES DE ADICION DE ACIDO O CUATERNARIAS FISIOLOGICAMENTE COMPATIBLES, DE FORMULA (I), EN LA QUE R Y R Y R PUEDEN SER VARIOS RADICALES; R ES HIDROGENO; R ES HIDROGENO O FENILO, O R Y R REPRESENTAN JUNTOS UN ENLACE; R Y R SON HIDROGENO O JUNTOS REPRENSENTAN OXIGENO; Y N VALE 1 O 2. CONSISTE EN LA REACCION DE UN COMPUESTO DE FORMULA (II CON UNA AMINA DE FORMULA R R NH, EN LAS QUE R TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I) Y Z PUEDE SER VARIOS RADICALES. LA REACCION SE LLEVA A CABO EN UN DISOLVENTE ORGANICO O EN MEDIO ACUORGANICO, A UNA TEMPERATURA COMPRENDIDA ENTRE 50<025>C Y 90<025>C. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DE ENFERMEDADES CARDIACAS.
ES504419A 1980-12-16 1981-07-17 Procedimiento de preparar benzopiranos 7-substituidos Granted ES504419A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU803001A HU184359B (en) 1980-12-16 1980-12-16 Process for preparing substituted acyl-carbamides

Publications (2)

Publication Number Publication Date
ES8301958A1 true ES8301958A1 (es) 1983-01-01
ES504419A0 ES504419A0 (es) 1983-01-01

Family

ID=10962081

Family Applications (2)

Application Number Title Priority Date Filing Date
ES504419A Granted ES504419A0 (es) 1980-12-16 1981-07-17 Procedimiento de preparar benzopiranos 7-substituidos
ES514678A Granted ES514678A0 (es) 1980-12-16 1982-07-16 "procedimiento de preparar benzopiranos 7-substituidos y similares".

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES514678A Granted ES514678A0 (es) 1980-12-16 1982-07-16 "procedimiento de preparar benzopiranos 7-substituidos y similares".

Country Status (20)

Country Link
US (1) US4391821A (es)
JP (1) JPS57109780A (es)
AU (1) AU7308781A (es)
BE (1) BE889665A (es)
DD (1) DD201305A5 (es)
DE (1) DE3127421A1 (es)
DK (1) DK320681A (es)
ES (2) ES504419A0 (es)
FI (1) FI812215L (es)
FR (1) FR2496102A1 (es)
GB (1) GB2089338B (es)
GR (1) GR74595B (es)
HU (1) HU184359B (es)
IL (1) IL63267A0 (es)
NL (1) NL8103403A (es)
NO (1) NO812466L (es)
PL (2) PL237708A1 (es)
PT (1) PT73395B (es)
SE (1) SE8104435L (es)
YU (1) YU177181A (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4668804A (en) * 1981-05-01 1987-05-26 Pennwalt Corporation Chromones
US4501755A (en) * 1981-05-01 1985-02-26 Pennwalt Corporation Isoflavones useful as anti-inflammatory agents
US4495198A (en) * 1981-05-01 1985-01-22 Pennwalt Corporation Antihypertensive chromonoxypropanolamines
US4668805A (en) * 1981-05-01 1987-05-26 Pennwalt Corporation Chromones
AU548450B2 (en) * 1983-08-08 1985-12-12 G.D. Searle & Co. Substituted dihydrobenzopyrans
US4678787A (en) * 1985-01-30 1987-07-07 Warner-Lambert Company 4H-1-benzopyran-4-ones and their sulfur containing analogs
US4797498A (en) * 1986-07-18 1989-01-10 Pennwalt Corporation Flavonoxypropanolamines and esters of flavonoxypropanolamines as antiarrhythmic agents
US4758678A (en) * 1986-07-18 1988-07-19 Pennwalt Corporation Preparation of 7-(2,3-epoxypropoxy)flavone
US4889941A (en) * 1987-04-23 1989-12-26 Fisons Corporation Synthetic flavonoids as inhibitors of leukotrienes and 5-lipoxygenase
US4971982A (en) * 1987-07-06 1990-11-20 Hoffmann-La Roche Inc. Benzopyran derivatives
US4806660A (en) * 1987-11-06 1989-02-21 Pennwalt Corporation Aurone oxypropanolamines
HUT58275A (en) * 1987-12-11 1992-02-28 Mitsui Petrochemical Ind Process for producing amines and pharmaceutical compositions containing them
US4950684A (en) * 1988-05-20 1990-08-21 G. D. Searle & Co. 2,2-di-substituted benzopyran leukotriene-D4 antagonists
US5219883A (en) * 1988-05-20 1993-06-15 G. D. Searle & Co. 2,2-di-substituted benzopyran leukotriene-D4 antagonists
US5093353A (en) * 1988-05-20 1992-03-03 G. D. Searle & Co. 2,2-di-substituted benzopyran leukotriene-D4 antagonists
US20010018446A1 (en) 1999-09-23 2001-08-30 G.D. Searle & Co. Substituted N-Aliphatic-N-Aromatictertiary-Heteroalkylamines useful for inhibiting cholesteryl ester transfer protein activity
JP2007008822A (ja) * 2005-06-28 2007-01-18 Tokuyama Corp ジヒドロベンゾピラン誘導体の製造方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3046275A (en) * 1958-05-30 1962-07-24 Chemiewerk Homburg Zweignieder N-substituted 2-phenyl-7-aminoalkoxy chromones
DE2123923A1 (de) * 1971-05-14 1972-11-23 Boehringer Mannheim Gmbh, 6800 Mannheim 4-eckige Klammer auf omega- (Flavon-7yl-oxy) -alkyl eckige Klammer zu -pigerazin-Derivate und Verfahren zu ihrer Herstellung
GB1493998A (en) * 1975-06-03 1977-12-07 Beecham Group Ltd Propanolamine derivatives
EP0017352A3 (en) * 1979-03-24 1981-01-07 Beecham Group Plc Chromanone derivatives, a process for their preparation, compositions containing them

Also Published As

Publication number Publication date
IL63267A0 (en) 1981-10-30
FI812215L (fi) 1982-06-17
GR74595B (es) 1984-06-29
PT73395B (en) 1982-10-01
PL232234A1 (en) 1983-06-06
YU177181A (en) 1983-10-31
ES8401053A1 (es) 1983-12-16
AU7308781A (en) 1982-06-24
NO812466L (no) 1982-06-17
SE8104435L (sv) 1982-06-17
DE3127421A1 (de) 1982-08-19
JPS57109780A (en) 1982-07-08
DD201305A5 (de) 1983-07-13
FR2496102A1 (fr) 1982-06-18
NL8103403A (nl) 1982-07-16
PL237708A1 (en) 1983-06-20
PT73395A (pt) 1981-08-01
HU184359B (en) 1984-08-28
ES514678A0 (es) 1983-12-16
DK320681A (da) 1982-06-17
GB2089338A (en) 1982-06-23
ES504419A0 (es) 1983-01-01
GB2089338B (en) 1984-02-22
US4391821A (en) 1983-07-05
BE889665A (fr) 1981-11-16

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