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ES544259A0 - Procedimiento para preparar nuevos acidos 3-(5-aminopentil)-amino-1-benzazepin-2-ona-1-alcanoico - Google Patents

Procedimiento para preparar nuevos acidos 3-(5-aminopentil)-amino-1-benzazepin-2-ona-1-alcanoico

Info

Publication number
ES544259A0
ES544259A0 ES544259A ES544259A ES544259A0 ES 544259 A0 ES544259 A0 ES 544259A0 ES 544259 A ES544259 A ES 544259A ES 544259 A ES544259 A ES 544259A ES 544259 A0 ES544259 A0 ES 544259A0
Authority
ES
Spain
Prior art keywords
aminopentil
alcanoico
benzazepin
ona
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES544259A
Other languages
English (en)
Other versions
ES8700239A1 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of ES544259A0 publication Critical patent/ES544259A0/es
Publication of ES8700239A1 publication Critical patent/ES8700239A1/es
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D223/00Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16Benzazepines; Hydrogenated benzazepines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06008Dipeptides with the first amino acid being neutral
    • C07K5/06017Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06086Dipeptides with the first amino acid being basic
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
ES544259A 1983-02-10 1985-06-17 Procedimiento para preparar nuevos acidos 3-(5-aminopentil)-amino-1-benzazepin-2-ona-1-alcanoico Expired ES8700239A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/465,695 US4473575A (en) 1982-07-19 1983-02-10 3-Amino-(1)-benzazepin-2-one-1-alkanoic acids

Publications (2)

Publication Number Publication Date
ES544259A0 true ES544259A0 (es) 1986-10-16
ES8700239A1 ES8700239A1 (es) 1986-10-16

Family

ID=23848805

Family Applications (10)

Application Number Title Priority Date Filing Date
ES529595A Expired ES8707216A1 (es) 1983-02-10 1984-02-09 Procedimiento para preparar nuevos acidos 3-(5-aminopentil)-amino-1-benzazepin-2-ona-1-alcanoicos
ES529594A Expired ES8609261A1 (es) 1983-02-10 1984-02-09 Procedimiento para preparar nuevos acidos 3-amino-1-benzazepin-2-ona-1-alcanoicos
ES544127A Expired ES8702363A1 (es) 1983-02-10 1985-06-13 Procedimiento para preparar nuevos acidos 3-amino-1-benzaze-pin-2-ona-1-alcanoicos
ES544260A Expired ES8609265A1 (es) 1983-02-10 1985-06-17 Procedimiento para preparar nuevos acidos 3-(5-aminopentil)-amino-1-benzazepin-2-ona-1-alcanoico
ES544258A Expired ES8609264A1 (es) 1983-02-10 1985-06-17 Procedimiento para preparar nuevos acidos 3-(5-aminopentil)-amino-1-benzazepin-2-ona-1-alcanoico
ES544255A Expired ES8609262A1 (es) 1983-02-10 1985-06-17 Procedimiento para preparar nuevos acidos 3-(5-aminopentil)-amino-1-benzazepin-2-ona-1-alcanoico
ES544254A Expired ES8703859A1 (es) 1983-02-10 1985-06-17 Procedimiento para preparar nuevos acidos 3-(5-aminopentil)-amino-1-benzazepin-2-ona-1-alcanoico
ES544257A Expired ES8609263A1 (es) 1983-02-10 1985-06-17 Procedimiento para preparar nuevos acidos 3-(5-aminopentil)-amino-1-benzazepin-2-ona-1-alcanoico
ES544259A Expired ES8700239A1 (es) 1983-02-10 1985-06-17 Procedimiento para preparar nuevos acidos 3-(5-aminopentil)-amino-1-benzazepin-2-ona-1-alcanoico
ES544256A Expired ES8705409A1 (es) 1983-02-10 1985-06-17 Procedimiento para preparar nuevos acidos 3-(5-aminopentil)-amino-1-benzazepin-2-ona-1-alcanoico

Family Applications Before (8)

Application Number Title Priority Date Filing Date
ES529595A Expired ES8707216A1 (es) 1983-02-10 1984-02-09 Procedimiento para preparar nuevos acidos 3-(5-aminopentil)-amino-1-benzazepin-2-ona-1-alcanoicos
ES529594A Expired ES8609261A1 (es) 1983-02-10 1984-02-09 Procedimiento para preparar nuevos acidos 3-amino-1-benzazepin-2-ona-1-alcanoicos
ES544127A Expired ES8702363A1 (es) 1983-02-10 1985-06-13 Procedimiento para preparar nuevos acidos 3-amino-1-benzaze-pin-2-ona-1-alcanoicos
ES544260A Expired ES8609265A1 (es) 1983-02-10 1985-06-17 Procedimiento para preparar nuevos acidos 3-(5-aminopentil)-amino-1-benzazepin-2-ona-1-alcanoico
ES544258A Expired ES8609264A1 (es) 1983-02-10 1985-06-17 Procedimiento para preparar nuevos acidos 3-(5-aminopentil)-amino-1-benzazepin-2-ona-1-alcanoico
ES544255A Expired ES8609262A1 (es) 1983-02-10 1985-06-17 Procedimiento para preparar nuevos acidos 3-(5-aminopentil)-amino-1-benzazepin-2-ona-1-alcanoico
ES544254A Expired ES8703859A1 (es) 1983-02-10 1985-06-17 Procedimiento para preparar nuevos acidos 3-(5-aminopentil)-amino-1-benzazepin-2-ona-1-alcanoico
ES544257A Expired ES8609263A1 (es) 1983-02-10 1985-06-17 Procedimiento para preparar nuevos acidos 3-(5-aminopentil)-amino-1-benzazepin-2-ona-1-alcanoico

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES544256A Expired ES8705409A1 (es) 1983-02-10 1985-06-17 Procedimiento para preparar nuevos acidos 3-(5-aminopentil)-amino-1-benzazepin-2-ona-1-alcanoico

Country Status (24)

Country Link
US (1) US4473575A (es)
EP (2) EP0119954B1 (es)
JP (2) JPS59172473A (es)
KR (1) KR900009023B1 (es)
AR (8) AR242564A1 (es)
AT (2) ATE50989T1 (es)
AU (1) AU574061B2 (es)
CA (2) CA1225397A (es)
CY (1) CY1674A (es)
DD (1) DD218359A5 (es)
DE (2) DE3481612D1 (es)
DK (2) DK58184A (es)
ES (10) ES8707216A1 (es)
FI (1) FI77857C (es)
GR (1) GR79809B (es)
HK (1) HK97592A (es)
HU (1) HU192394B (es)
IE (1) IE56858B1 (es)
IL (1) IL70881A (es)
NO (1) NO166232C (es)
NZ (1) NZ207091A (es)
PT (1) PT78075B (es)
SG (1) SG94992G (es)
ZA (1) ZA84958B (es)

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US4575503A (en) * 1983-02-10 1986-03-11 Ciba-Geigy Corporation 3-Amino-[1]-benzazepin-2-one-1-alkanoic acids
US4600534A (en) * 1984-02-06 1986-07-15 Ciba-Geigy Corporation Process and intermediates for manufacture of 3-(5-amino-1-carboxypentylamino)-tetrahydro-1-benzazepin-2-one-1-acetic acid
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DE3767514D1 (de) * 1986-03-11 1991-02-28 Thompson Barry Antony Fuettern von vieh mit polymeren.
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US4410520A (en) * 1981-11-09 1983-10-18 Ciba-Geigy Corporation 3-Amino-[1]-benzazepin-2-one-1-alkanoic acids
US4473575A (en) * 1982-07-19 1984-09-25 Ciba-Geigy Corporation 3-Amino-(1)-benzazepin-2-one-1-alkanoic acids
DE3373469D1 (en) * 1982-09-30 1987-10-15 Merck & Co Inc 1-n-alkylcarboxy-benzofused lactams useful as antihypertensive agents

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EP0119955B1 (de) 1989-12-13
FI840513A (fi) 1984-08-11
PT78075A (en) 1984-03-01
DD218359A5 (de) 1985-02-06
ES8705409A1 (es) 1987-05-01
EP0119954A2 (de) 1984-09-26
ES8609261A1 (es) 1986-07-16
DK171257B1 (da) 1996-08-12
EP0119955A3 (en) 1986-06-11
AR242191A1 (es) 1993-03-31
IE56858B1 (en) 1992-01-01
NZ207091A (en) 1985-11-08
AR243165A1 (es) 1993-07-30
ZA84958B (en) 1984-09-26
CA1225397A (en) 1987-08-11
AR243164A1 (es) 1993-07-30
AR243163A1 (es) 1993-07-30
NO166232C (no) 1991-06-19
ATE50989T1 (de) 1990-03-15
PT78075B (en) 1986-06-11
AR242564A1 (es) 1993-04-30
ES529595A0 (es) 1987-07-16
DK58184D0 (da) 1984-02-09
HU192394B (en) 1987-06-29
ES544254A0 (es) 1987-03-01
IL70881A0 (en) 1984-05-31
ES8609262A1 (es) 1986-09-01
IE840302L (en) 1984-08-10
DE3480705D1 (de) 1990-01-18
ES8609265A1 (es) 1986-09-01
FI77857B (fi) 1989-01-31
ES8700239A1 (es) 1986-10-16
AU574061B2 (en) 1988-06-30
NO166232B (no) 1991-03-11
FI840513A0 (fi) 1984-02-08
EP0119955A2 (de) 1984-09-26
ES8609264A1 (es) 1986-09-01
GR79809B (es) 1984-10-31
KR840007722A (ko) 1984-12-10
ES544255A0 (es) 1986-09-01
ES8609263A1 (es) 1986-09-01
DK58184A (da) 1984-08-11
AR243162A1 (es) 1993-07-30
AR243161A1 (es) 1993-07-30
JPH0460108B2 (es) 1992-09-25
ES8703859A1 (es) 1987-03-01
KR900009023B1 (ko) 1990-12-17
NO840487L (no) 1984-08-13
FI77857C (fi) 1989-05-10
EP0119954B1 (de) 1990-03-14
US4473575A (en) 1984-09-25
ES544256A0 (es) 1987-05-01
AR242190A1 (es) 1993-03-31
EP0119954A3 (en) 1986-06-11
ES544127A0 (es) 1987-01-01
HK97592A (en) 1992-12-11
ES544258A0 (es) 1986-09-01
JPS59172473A (ja) 1984-09-29
ES8707216A1 (es) 1987-07-16
ES529594A0 (es) 1986-07-16
ATE48598T1 (de) 1989-12-15
AU2443084A (en) 1984-08-16
JPH0421665B2 (es) 1992-04-13
DK58284A (da) 1984-08-11
DE3481612D1 (de) 1990-04-19
JPS59172475A (ja) 1984-09-29
ES544260A0 (es) 1986-09-01
ES8702363A1 (es) 1987-01-01
SG94992G (en) 1992-12-04
IL70881A (en) 1987-10-30
ES544257A0 (es) 1986-09-01
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DK58284D0 (da) 1984-02-09
CA1218993A (en) 1987-03-10

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