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ES8700239A1 - Procedimiento para preparar nuevos acidos 3-(5-aminopentil)-amino-1-benzazepin-2-ona-1-alcanoico - Google Patents

Procedimiento para preparar nuevos acidos 3-(5-aminopentil)-amino-1-benzazepin-2-ona-1-alcanoico

Info

Publication number
ES8700239A1
ES8700239A1 ES544259A ES544259A ES8700239A1 ES 8700239 A1 ES8700239 A1 ES 8700239A1 ES 544259 A ES544259 A ES 544259A ES 544259 A ES544259 A ES 544259A ES 8700239 A1 ES8700239 A1 ES 8700239A1
Authority
ES
Spain
Prior art keywords
benzazepin
opt
preparation
lower alkyl
tetrahydro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES544259A
Other languages
English (en)
Other versions
ES544259A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of ES544259A0 publication Critical patent/ES544259A0/es
Publication of ES8700239A1 publication Critical patent/ES8700239A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

PROCEDIMIENTO DE PREPARACION DE ACIDOS 3-(5-AMINOPENTIL)-AMINO-1-BENZAZEPIN-2-ONA-1-ALCANOLICOS DE FORMULA (I), DONDE R1 ES 4-AMINOBUTILO, R2 T R3 REPRESENTAN INDEPENDIENTEMENTE UN HIDROXI O ALCOXI INFERIOR, C1-C7 Y S REPRESENTA LA QUIRALIDAD, Y DE SUS SALES FARMACEUTICAMENTE ACTIVAS. CONSISTE EN ABRIR EL ANILLO DE LACTAMA MONOCICLICA II POR TRATAMIENTO CON UN ACIDO MINERAL FUERTE, PREFERENTEMENTE A TEMPERATURAS ELEVADAS. LOS COMPUESTOS SE ADMINISTRAN POR VIA ENYTERAL O PARENTERAL, ORAL O INTRAVENOSA, EN DOSIS DE 0,001-30 MG/KG/DIA. ACTUAN COMO INHIBIDORES DE LA SECRECION DE ANGIOTENSINA II Y SON HIPOTENSIVOS O ANTIHIPERTENSIVOS.
ES544259A 1983-02-10 1985-06-17 Procedimiento para preparar nuevos acidos 3-(5-aminopentil)-amino-1-benzazepin-2-ona-1-alcanoico Expired ES8700239A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/465,695 US4473575A (en) 1982-07-19 1983-02-10 3-Amino-(1)-benzazepin-2-one-1-alkanoic acids

Publications (2)

Publication Number Publication Date
ES544259A0 ES544259A0 (es) 1986-10-16
ES8700239A1 true ES8700239A1 (es) 1986-10-16

Family

ID=23848805

Family Applications (10)

Application Number Title Priority Date Filing Date
ES529594A Expired ES8609261A1 (es) 1983-02-10 1984-02-09 Procedimiento para preparar nuevos acidos 3-amino-1-benzazepin-2-ona-1-alcanoicos
ES529595A Expired ES8707216A1 (es) 1983-02-10 1984-02-09 Procedimiento para preparar nuevos acidos 3-(5-aminopentil)-amino-1-benzazepin-2-ona-1-alcanoicos
ES544127A Expired ES8702363A1 (es) 1983-02-10 1985-06-13 Procedimiento para preparar nuevos acidos 3-amino-1-benzaze-pin-2-ona-1-alcanoicos
ES544259A Expired ES8700239A1 (es) 1983-02-10 1985-06-17 Procedimiento para preparar nuevos acidos 3-(5-aminopentil)-amino-1-benzazepin-2-ona-1-alcanoico
ES544256A Expired ES8705409A1 (es) 1983-02-10 1985-06-17 Procedimiento para preparar nuevos acidos 3-(5-aminopentil)-amino-1-benzazepin-2-ona-1-alcanoico
ES544260A Expired ES8609265A1 (es) 1983-02-10 1985-06-17 Procedimiento para preparar nuevos acidos 3-(5-aminopentil)-amino-1-benzazepin-2-ona-1-alcanoico
ES544254A Expired ES8703859A1 (es) 1983-02-10 1985-06-17 Procedimiento para preparar nuevos acidos 3-(5-aminopentil)-amino-1-benzazepin-2-ona-1-alcanoico
ES544257A Expired ES8609263A1 (es) 1983-02-10 1985-06-17 Procedimiento para preparar nuevos acidos 3-(5-aminopentil)-amino-1-benzazepin-2-ona-1-alcanoico
ES544258A Expired ES8609264A1 (es) 1983-02-10 1985-06-17 Procedimiento para preparar nuevos acidos 3-(5-aminopentil)-amino-1-benzazepin-2-ona-1-alcanoico
ES544255A Expired ES8609262A1 (es) 1983-02-10 1985-06-17 Procedimiento para preparar nuevos acidos 3-(5-aminopentil)-amino-1-benzazepin-2-ona-1-alcanoico

Family Applications Before (3)

Application Number Title Priority Date Filing Date
ES529594A Expired ES8609261A1 (es) 1983-02-10 1984-02-09 Procedimiento para preparar nuevos acidos 3-amino-1-benzazepin-2-ona-1-alcanoicos
ES529595A Expired ES8707216A1 (es) 1983-02-10 1984-02-09 Procedimiento para preparar nuevos acidos 3-(5-aminopentil)-amino-1-benzazepin-2-ona-1-alcanoicos
ES544127A Expired ES8702363A1 (es) 1983-02-10 1985-06-13 Procedimiento para preparar nuevos acidos 3-amino-1-benzaze-pin-2-ona-1-alcanoicos

Family Applications After (6)

Application Number Title Priority Date Filing Date
ES544256A Expired ES8705409A1 (es) 1983-02-10 1985-06-17 Procedimiento para preparar nuevos acidos 3-(5-aminopentil)-amino-1-benzazepin-2-ona-1-alcanoico
ES544260A Expired ES8609265A1 (es) 1983-02-10 1985-06-17 Procedimiento para preparar nuevos acidos 3-(5-aminopentil)-amino-1-benzazepin-2-ona-1-alcanoico
ES544254A Expired ES8703859A1 (es) 1983-02-10 1985-06-17 Procedimiento para preparar nuevos acidos 3-(5-aminopentil)-amino-1-benzazepin-2-ona-1-alcanoico
ES544257A Expired ES8609263A1 (es) 1983-02-10 1985-06-17 Procedimiento para preparar nuevos acidos 3-(5-aminopentil)-amino-1-benzazepin-2-ona-1-alcanoico
ES544258A Expired ES8609264A1 (es) 1983-02-10 1985-06-17 Procedimiento para preparar nuevos acidos 3-(5-aminopentil)-amino-1-benzazepin-2-ona-1-alcanoico
ES544255A Expired ES8609262A1 (es) 1983-02-10 1985-06-17 Procedimiento para preparar nuevos acidos 3-(5-aminopentil)-amino-1-benzazepin-2-ona-1-alcanoico

Country Status (24)

Country Link
US (1) US4473575A (es)
EP (2) EP0119955B1 (es)
JP (2) JPS59172473A (es)
KR (1) KR900009023B1 (es)
AR (8) AR242564A1 (es)
AT (2) ATE48598T1 (es)
AU (1) AU574061B2 (es)
CA (2) CA1225397A (es)
CY (1) CY1674A (es)
DD (1) DD218359A5 (es)
DE (2) DE3480705D1 (es)
DK (2) DK171257B1 (es)
ES (10) ES8609261A1 (es)
FI (1) FI77857C (es)
GR (1) GR79809B (es)
HK (1) HK97592A (es)
HU (1) HU192394B (es)
IE (1) IE56858B1 (es)
IL (1) IL70881A (es)
NO (1) NO166232C (es)
NZ (1) NZ207091A (es)
PT (1) PT78075B (es)
SG (1) SG94992G (es)
ZA (1) ZA84958B (es)

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US4575503A (en) * 1983-02-10 1986-03-11 Ciba-Geigy Corporation 3-Amino-[1]-benzazepin-2-one-1-alkanoic acids
US4537885A (en) * 1983-02-10 1985-08-27 Ciba Geigy Corporation Certain benzazocinone and benzazoninone derivatives
US4600534A (en) * 1984-02-06 1986-07-15 Ciba-Geigy Corporation Process and intermediates for manufacture of 3-(5-amino-1-carboxypentylamino)-tetrahydro-1-benzazepin-2-one-1-acetic acid
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US4785089A (en) * 1985-06-13 1988-11-15 Ciba-Geigy Corporation Novel sulfonic acid esters and their preparation
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DE3481612D1 (de) 1990-04-19
FI77857C (fi) 1989-05-10
ES8609265A1 (es) 1986-09-01
EP0119954B1 (de) 1990-03-14
ES544127A0 (es) 1987-01-01
ES529595A0 (es) 1987-07-16
AR242190A1 (es) 1993-03-31
US4473575A (en) 1984-09-25
AR243162A1 (es) 1993-07-30
IE840302L (en) 1984-08-10
EP0119954A2 (de) 1984-09-26
AR243163A1 (es) 1993-07-30
DK58184A (da) 1984-08-11
ES544260A0 (es) 1986-09-01
JPH0460108B2 (es) 1992-09-25
DK58184D0 (da) 1984-02-09
ES544259A0 (es) 1986-10-16
ES8707216A1 (es) 1987-07-16
CA1225397A (en) 1987-08-11
PT78075A (en) 1984-03-01
ATE50989T1 (de) 1990-03-15
ES8609261A1 (es) 1986-07-16
IL70881A (en) 1987-10-30
GR79809B (es) 1984-10-31
ES8609264A1 (es) 1986-09-01
ES544254A0 (es) 1987-03-01
AR242564A1 (es) 1993-04-30
IE56858B1 (en) 1992-01-01
NO840487L (no) 1984-08-13
EP0119955A3 (en) 1986-06-11
ES8609262A1 (es) 1986-09-01
NO166232B (no) 1991-03-11
AU2443084A (en) 1984-08-16
ES8703859A1 (es) 1987-03-01
PT78075B (en) 1986-06-11
EP0119955B1 (de) 1989-12-13
ES529594A0 (es) 1986-07-16
ZA84958B (en) 1984-09-26
NZ207091A (en) 1985-11-08
ES544255A0 (es) 1986-09-01
NO166232C (no) 1991-06-19
EP0119954A3 (en) 1986-06-11
DD218359A5 (de) 1985-02-06
EP0119955A2 (de) 1984-09-26
KR840007722A (ko) 1984-12-10
FI77857B (fi) 1989-01-31
DE3480705D1 (de) 1990-01-18
JPS59172475A (ja) 1984-09-29
DK58284D0 (da) 1984-02-09
ES8705409A1 (es) 1987-05-01
ES544256A0 (es) 1987-05-01
DK171257B1 (da) 1996-08-12
ES544257A0 (es) 1986-09-01
ES8702363A1 (es) 1987-01-01
FI840513A0 (fi) 1984-02-08
ATE48598T1 (de) 1989-12-15
ES8609263A1 (es) 1986-09-01
AR243161A1 (es) 1993-07-30
JPS59172473A (ja) 1984-09-29
SG94992G (en) 1992-12-04
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FI840513A (fi) 1984-08-11
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ES544258A0 (es) 1986-09-01
AR242191A1 (es) 1993-03-31
DK58284A (da) 1984-08-11
HU192394B (en) 1987-06-29
AU574061B2 (en) 1988-06-30
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IL70881A0 (en) 1984-05-31
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AR243164A1 (es) 1993-07-30

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