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ES383587A1 - Benzodiazepine derivatives - Google Patents

Benzodiazepine derivatives

Info

Publication number
ES383587A1
ES383587A1 ES383587A ES383587A ES383587A1 ES 383587 A1 ES383587 A1 ES 383587A1 ES 383587 A ES383587 A ES 383587A ES 383587 A ES383587 A ES 383587A ES 383587 A1 ES383587 A1 ES 383587A1
Authority
ES
Spain
Prior art keywords
alkyl
compounds
benzodiazepine derivatives
hypnotics
cooc
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES383587A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Chemical Co Ltd
Original Assignee
Sumitomo Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sumitomo Chemical Co Ltd filed Critical Sumitomo Chemical Co Ltd
Publication of ES383587A1 publication Critical patent/ES383587A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • C07D243/26—Preparation from compounds already containing the benzodiazepine skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • C07D243/30—Preparation including building-up the benzodiazepine skeleton from compounds already containing hetero rings
    • C07D243/36—Preparation including building-up the benzodiazepine skeleton from compounds already containing hetero rings containing an indole or hydrogenated indole ring system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Compounds of the general formula (R 1 =H, halogen, NO 2 , CF 3 R 2 , 3 =H, Cl, Br, C 1-4 alkyl, CF 3 R 4 =C 1-4 alkyl n=1-3) and their acid addition salts are prepared by (a)reacting the corresponding 1-unsubstituted benzodiazepine derivative with a reactive ester of R 4 COOC n H 2n OH or (b) indole ring-expansion, optionally followed by salt formation in either case. The above compounds are sedatives, muscle relaxants, hypnotics and anticonvulsants, and may be administered in the form of pharmaceutical preparations containing them in association with a carrier.
ES383587A 1969-05-16 1970-09-12 Benzodiazepine derivatives Expired ES383587A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP44038183A JPS4811718B1 (en) 1969-05-16 1969-05-16

Publications (1)

Publication Number Publication Date
ES383587A1 true ES383587A1 (en) 1973-01-01

Family

ID=12518255

Family Applications (2)

Application Number Title Priority Date Filing Date
ES379701A Expired ES379701A1 (en) 1969-05-16 1970-05-14 Benzodiazepine derivatives
ES383587A Expired ES383587A1 (en) 1969-05-16 1970-09-12 Benzodiazepine derivatives

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES379701A Expired ES379701A1 (en) 1969-05-16 1970-05-14 Benzodiazepine derivatives

Country Status (12)

Country Link
JP (1) JPS4811718B1 (en)
AT (2) AT300815B (en)
BE (1) BE750524A (en)
CA (1) CA946844A (en)
CH (1) CH537396A (en)
CS (1) CS169804B2 (en)
ES (2) ES379701A1 (en)
FR (1) FR2051534B1 (en)
GB (1) GB1272887A (en)
NL (1) NL161749C (en)
SE (1) SE372269B (en)
ZA (1) ZA703130B (en)

Also Published As

Publication number Publication date
FR2051534B1 (en) 1974-04-12
BE750524A (en) 1970-10-16
DE2023182A1 (en) 1970-11-19
FR2051534A1 (en) 1971-04-09
AT308125B (en) 1973-06-25
CA946844A (en) 1974-05-07
SE372269B (en) 1974-12-16
ZA703130B (en) 1971-01-27
NL161749B (en) 1979-10-15
GB1272887A (en) 1972-05-03
DE2023182B2 (en) 1975-08-28
ES379701A1 (en) 1972-08-01
NL161749C (en) 1980-03-17
NL7007057A (en) 1970-11-18
JPS4811718B1 (en) 1973-04-14
CH537396A (en) 1973-05-31
CS169804B2 (en) 1976-07-29
AT300815B (en) 1972-08-10

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