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GB1276169A - Benzodiazepine derivatives - Google Patents

Benzodiazepine derivatives

Info

Publication number
GB1276169A
GB1276169A GB34002/71A GB3400271A GB1276169A GB 1276169 A GB1276169 A GB 1276169A GB 34002/71 A GB34002/71 A GB 34002/71A GB 3400271 A GB3400271 A GB 3400271A GB 1276169 A GB1276169 A GB 1276169A
Authority
GB
United Kingdom
Prior art keywords
alkyl
sept
compounds
formula
benzodiazepine derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB34002/71A
Inventor
Kanji Meguro
Hiroyuki Tawada
Yutaka Kuwada
Toru Masuda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of GB1276169A publication Critical patent/GB1276169A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05C—APPARATUS FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05C11/00—Component parts, details or accessories not specifically provided for in groups B05C1/00 - B05C9/00
    • B05C11/11—Vats or other containers for liquids or other fluent materials
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B26—HAND CUTTING TOOLS; CUTTING; SEVERING
    • B26D—CUTTING; DETAILS COMMON TO MACHINES FOR PERFORATING, PUNCHING, CUTTING-OUT, STAMPING-OUT OR SEVERING
    • B26D3/00—Cutting work characterised by the nature of the cut made; Apparatus therefor
    • B26D3/18—Cutting work characterised by the nature of the cut made; Apparatus therefor to obtain cubes or the like
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • C07D243/26—Preparation from compounds already containing the benzodiazepine skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • C07D243/28—Preparation including building-up the benzodiazepine skeleton from compounds containing no hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Forests & Forestry (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Mechanical Engineering (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

1276169 Benzodiazepines TAKEDA YAKUHIN KOGYO KK 3 Sept 1969 [3 Sept 1968 (2)] 34002/71 Divided out of 1276168 Heading C2C Compounds of the general formula (R 1 = alkyl or cycloalkyl containing up to 6 carbon atoms; rings A, B optionally substituted by one or more substituents selected from NO 2 , CF 3 , halogen, alkyl, alkoxy) and their acid addition salts are prepared by ring-closing a compound of the formula (R 2 =alkyl) and hydrolysing the product, optionally followed by salt formation. The above compounds are tranquillizers, muscle relaxants and anticonvulsants, and may be administered in the form of pharmaceutical preparations containing them in association with a carrier.
GB34002/71A 1968-09-03 1969-09-03 Benzodiazepine derivatives Expired GB1276169A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP6332468 1968-09-03
JP6332368 1968-09-03

Publications (1)

Publication Number Publication Date
GB1276169A true GB1276169A (en) 1972-06-01

Family

ID=26404426

Family Applications (2)

Application Number Title Priority Date Filing Date
GB34002/71A Expired GB1276169A (en) 1968-09-03 1969-09-03 Benzodiazepine derivatives
GB43519/69A Expired GB1276168A (en) 1968-09-03 1969-09-03 Benzodiazepine derivatives preparation

Family Applications After (1)

Application Number Title Priority Date Filing Date
GB43519/69A Expired GB1276168A (en) 1968-09-03 1969-09-03 Benzodiazepine derivatives preparation

Country Status (9)

Country Link
US (1) US3692772A (en)
CH (1) CH535243A (en)
DE (2) DE1944404C3 (en)
ES (1) ES371134A1 (en)
FR (1) FR2017275B1 (en)
GB (2) GB1276169A (en)
NL (1) NL165158C (en)
NO (1) NO124035B (en)
SE (1) SE349807B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1484661A (en) * 1975-01-06 1977-09-01 Clin Midy Preparatin of benzodiazepine derivatives
CN110003125A (en) * 2019-04-24 2019-07-12 湖北美林药业有限公司 A kind of diazepam, diazepam injection and preparation method thereof
CN114276375A (en) * 2021-12-15 2022-04-05 重庆医科大学 Synthesis method of 1,3, 2-benzodiazepine borane ketone and derivatives thereof
CN115197261B (en) * 2022-07-06 2024-05-03 重庆医科大学 Synthesis method of oxadiazine boron derivative

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1411072A (en) * 1963-07-10 1965-09-17 Hoffmann La Roche Process for the preparation of benzodiazepine derivatives
NL6409554A (en) * 1964-08-19 1966-02-21
US3558603A (en) * 1967-12-01 1971-01-26 Sumitomo Chemical Co Process for producing benzodiazepine derivatives

Also Published As

Publication number Publication date
DE1966132B2 (en) 1981-07-23
DE1944404B2 (en) 1979-01-11
NL165158C (en) 1981-03-16
ES371134A1 (en) 1972-01-01
US3692772A (en) 1972-09-19
DE1944404C3 (en) 1979-09-13
CH535243A (en) 1973-03-31
NL165158B (en) 1980-10-15
NL6913339A (en) 1970-03-05
SE349807B (en) 1972-10-09
DE1966132A1 (en) 1971-08-19
DE1944404A1 (en) 1970-03-12
FR2017275B1 (en) 1973-06-08
FR2017275A1 (en) 1970-05-22
NO124035B (en) 1972-02-21
GB1276168A (en) 1972-06-01

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee