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ES2124062T3 - Derivados de nucleosido fosforotioato, sintesis y uso de los mismos. - Google Patents

Derivados de nucleosido fosforotioato, sintesis y uso de los mismos.

Info

Publication number
ES2124062T3
ES2124062T3 ES96300390T ES96300390T ES2124062T3 ES 2124062 T3 ES2124062 T3 ES 2124062T3 ES 96300390 T ES96300390 T ES 96300390T ES 96300390 T ES96300390 T ES 96300390T ES 2124062 T3 ES2124062 T3 ES 2124062T3
Authority
ES
Spain
Prior art keywords
nucleoside
sup
phosphorotioate
appropriate
synthesis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96300390T
Other languages
English (en)
Inventor
Colin Bernard Reese
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kings College London
Original Assignee
Kings College London
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kings College London filed Critical Kings College London
Application granted granted Critical
Publication of ES2124062T3 publication Critical patent/ES2124062T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • C07D207/48—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Saccharide Compounds (AREA)

Abstract

SE PRESENTA, ENTRE OTRAS COSAS UN PROCESO PARA LA PRODUCCION DE UN DERIVADO DE FOSFOROTIOATO NUCLEOSIDO QUE CORRESPONDE A LA SIGUIENTE FORMULA GENERAL (I): CARACTERIZADO EN QUE COMPRENDE LA REACCION DE UNA SAL DE UN NUCLEOSIDO H-FOSFONADO QUE CORRESPONDE A LA SIGUIENTE FORMULA GENERAL (II): CON UN AGENTE DE TRANSFERENCIA DE TIOL QUE CORRESPONDE A LA SIGUIENTE FORMULA GENERAL (III): R{SUP,2}-S-X (III) EN PRESENCIA DE UN AGENTE DE SILILACION Y DE UNA BASE EN UN DISOLVENTE APROPIADO; Y TRATAR LA MEZCLA DE REACCION PARA AISLAR EL PRODUCTO DESEADO Y CAMBIAR EL CONTRA CATION COMO SE DESEE; EN DONDE M+ REPRESENTA UN CONTRACATION APROPIADO R{SUP,1} REPRESENTA UN NUCLEOSIDO APROPIADO O UN NUCLEOSIDO ANALOGO R{SUP,2} REPRESENTA EL GRUPO PROTECTOR DESEADO, QUE PUEDE AL FINAL ELIMINARSE POR DIVISION DE SU ENLACE CON EL ATOMO DE AZUFRE Y X REPRESENTA UN GRUPO DE PARTIDA.
ES96300390T 1995-01-25 1996-01-19 Derivados de nucleosido fosforotioato, sintesis y uso de los mismos. Expired - Lifetime ES2124062T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9501465.0A GB9501465D0 (en) 1995-01-25 1995-01-25 Nucleoside phosphorothioate derivatives,synthesis and use thereof

Publications (1)

Publication Number Publication Date
ES2124062T3 true ES2124062T3 (es) 1999-01-16

Family

ID=10768560

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96300390T Expired - Lifetime ES2124062T3 (es) 1995-01-25 1996-01-19 Derivados de nucleosido fosforotioato, sintesis y uso de los mismos.

Country Status (5)

Country Link
US (1) US5708161A (es)
EP (1) EP0723973B1 (es)
DE (1) DE69600799T2 (es)
ES (1) ES2124062T3 (es)
GB (1) GB9501465D0 (es)

Families Citing this family (76)

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Also Published As

Publication number Publication date
GB9501465D0 (en) 1995-03-15
EP0723973A1 (en) 1996-07-31
EP0723973B1 (en) 1998-10-21
DE69600799T2 (de) 1999-03-11
DE69600799D1 (de) 1998-11-26
US5708161A (en) 1998-01-13

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