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AR014738A1 - Nuevo procedimiento de preparacion de la fexofenadina y compuestos intermediarios - Google Patents

Nuevo procedimiento de preparacion de la fexofenadina y compuestos intermediarios

Info

Publication number
AR014738A1
AR014738A1 ARP990101165A ARP990101165A AR014738A1 AR 014738 A1 AR014738 A1 AR 014738A1 AR P990101165 A ARP990101165 A AR P990101165A AR P990101165 A ARP990101165 A AR P990101165A AR 014738 A1 AR014738 A1 AR 014738A1
Authority
AR
Argentina
Prior art keywords
fexofenadine
formula
preparation
compounds
new procedure
Prior art date
Application number
ARP990101165A
Other languages
English (en)
Original Assignee
Hoechst Marion Roussel Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Marion Roussel Inc filed Critical Hoechst Marion Roussel Inc
Publication of AR014738A1 publication Critical patent/AR014738A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/59—Hydrogenated pyridine rings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • C12P17/12—Nitrogen as only ring hetero atom containing a six-membered hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Procedimiento de preparacion de la fexofenadina de formula (I), en donde se efectua una bioconversion del o de los compuestos de formula (II) con ya sea uncultivo de un microorganismo del género Absidia corymbifera, ya sea un cultivo de un microorganismo del género Streptomyces, a un pH comprendido entre 5,0 y8,0 a fin de obtener el o los compuestos de formula (I) esperados, que llegado el caso son aislados, purificados y/o salificados, pudiendo los compuestos deformulas (I) o (II) estar en las dos formas enantiomeras posibles, aisladas o en mezclas. La Fexofenadina es un medicamento que posee una importanteactividad antihistamímica y que está desprovisto de efectos secundarios. Además describe un compuesto intermediario de formula (IIIc
ARP990101165A 1998-03-19 1999-03-17 Nuevo procedimiento de preparacion de la fexofenadina y compuestos intermediarios AR014738A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9803349A FR2776302B1 (fr) 1998-03-19 1998-03-19 Nouveau procede de preparation de la fexofenadine

Publications (1)

Publication Number Publication Date
AR014738A1 true AR014738A1 (es) 2001-03-28

Family

ID=9524214

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP990101165A AR014738A1 (es) 1998-03-19 1999-03-17 Nuevo procedimiento de preparacion de la fexofenadina y compuestos intermediarios

Country Status (15)

Country Link
US (2) US6558931B1 (es)
EP (1) EP1062358B1 (es)
JP (1) JP4291511B2 (es)
AR (1) AR014738A1 (es)
AT (1) ATE242333T1 (es)
AU (1) AU2842799A (es)
DE (1) DE69908569T2 (es)
DK (1) DK1062358T3 (es)
DZ (1) DZ2746A1 (es)
ES (1) ES2196783T3 (es)
FR (1) FR2776302B1 (es)
MA (1) MA26615A1 (es)
PT (1) PT1062358E (es)
TN (1) TNSN99042A1 (es)
WO (1) WO1999047693A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2776302B1 (fr) * 1998-03-19 2002-04-12 Hoechst Marion Roussel Inc Nouveau procede de preparation de la fexofenadine
GB0013368D0 (en) * 2000-05-31 2000-07-26 Pfizer Ltd Enzymatic oxidations
US6610518B2 (en) 2000-05-31 2003-08-26 Pfizer Inc. Enzymatic oxidations
US6613906B1 (en) * 2000-06-06 2003-09-02 Geneva Pharmaceuticals, Inc. Crystal modification
GB0018691D0 (en) * 2000-07-28 2000-09-20 Rolabo Sl Process
US6613907B2 (en) 2000-11-08 2003-09-02 Amr Technology, Inc. Process for the production of piperidine derivatives with microorganisms
BRPI0308445A2 (pt) * 2002-03-08 2016-08-02 M S Ind Swift Ltd complexos de rápida dissolução, diretamente compressíveis, sem sabor e formulações farmacêuticas dos mesmos
US20090076080A1 (en) * 2007-09-19 2009-03-19 Protia, Llc Deuterium-enriched fexofenadine

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995000480A1 (en) * 1993-06-25 1995-01-05 Merrell Pharmaceuticals Inc. Novel intermediates for the preparation of antihistaminic 4-diphenylmethyl/diphenylmethoxy piperidine derivatives
US6147216A (en) * 1993-06-25 2000-11-14 Merrell Pharmaceuticals Inc. Intermediates useful for the preparation of antihistaminic piperidine derivatives
PT864653E (pt) * 1997-03-11 2004-08-31 Aventis Pharma Inc Processo para preparacao de acido 4-(4-(4-(hidroxidifenil)-1-piperidinil)-1-hidroxibutil)-alfa,alfa-dimetilfenilacetico e derivados fosforilados
FR2776302B1 (fr) * 1998-03-19 2002-04-12 Hoechst Marion Roussel Inc Nouveau procede de preparation de la fexofenadine

Also Published As

Publication number Publication date
JP4291511B2 (ja) 2009-07-08
US6558931B1 (en) 2003-05-06
DZ2746A1 (fr) 2003-09-08
EP1062358A1 (fr) 2000-12-27
PT1062358E (pt) 2003-10-31
US7241601B2 (en) 2007-07-10
FR2776302A1 (fr) 1999-09-24
AU2842799A (en) 1999-10-11
US20060019358A1 (en) 2006-01-26
MA26615A1 (fr) 2004-12-20
ES2196783T3 (es) 2003-12-16
DK1062358T3 (da) 2003-09-29
EP1062358B1 (fr) 2003-06-04
TNSN99042A1 (fr) 2005-11-10
WO1999047693A1 (fr) 1999-09-23
DE69908569T2 (de) 2004-05-13
ATE242333T1 (de) 2003-06-15
DE69908569D1 (de) 2003-07-10
FR2776302B1 (fr) 2002-04-12
JP2002506653A (ja) 2002-03-05

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Legal Events

Date Code Title Description
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