ES2109189B1 - Vectores basados en genomas virales defectivos recombinantes y su empleo en la formulacion de vacunas. - Google Patents
Vectores basados en genomas virales defectivos recombinantes y su empleo en la formulacion de vacunas.Info
- Publication number
- ES2109189B1 ES2109189B1 ES9600620A ES9600620A ES2109189B1 ES 2109189 B1 ES2109189 B1 ES 2109189B1 ES 9600620 A ES9600620 A ES 9600620A ES 9600620 A ES9600620 A ES 9600620A ES 2109189 B1 ES2109189 B1 ES 2109189B1
- Authority
- ES
- Spain
- Prior art keywords
- genome
- defective viral
- virus
- vectors
- vaccines
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 230000002950 deficient Effects 0.000 title abstract 4
- 239000013598 vector Substances 0.000 title abstract 4
- 230000003612 virological effect Effects 0.000 title abstract 4
- 229960005486 vaccine Drugs 0.000 title abstract 2
- 238000009472 formulation Methods 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 241000700605 Viruses Species 0.000 abstract 3
- 230000010076 replication Effects 0.000 abstract 2
- 241000282472 Canis lupus familiaris Species 0.000 abstract 1
- 241000282693 Cercopithecidae Species 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 241000282887 Suidae Species 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 230000000295 complement effect Effects 0.000 abstract 1
- 230000006698 induction Effects 0.000 abstract 1
- 239000012678 infectious agent Substances 0.000 abstract 1
- 108010026228 mRNA guanylyltransferase Proteins 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 230000003248 secreting effect Effects 0.000 abstract 1
- 230000009885 systemic effect Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/215—Coronaviridae, e.g. avian infectious bronchitis virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/215—Coronaviridae, e.g. avian infectious bronchitis virus
- A61K39/225—Porcine transmissible gastroenteritis virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
- C07K16/1002—Coronaviridae
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5254—Virus avirulent or attenuated
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
- A61K2039/542—Mucosal route oral/gastrointestinal
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
- A61K2039/552—Veterinary vaccine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/10011—Arteriviridae
- C12N2770/10022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/10011—Arteriviridae
- C12N2770/10034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/20011—Coronaviridae
- C12N2770/20022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/20011—Coronaviridae
- C12N2770/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/20011—Coronaviridae
- C12N2770/20041—Use of virus, viral particle or viral elements as a vector
- C12N2770/20043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/20011—Coronaviridae
- C12N2770/20061—Methods of inactivation or attenuation
- C12N2770/20064—Methods of inactivation or attenuation by serial passage
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Communicable Diseases (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Biophysics (AREA)
- Pulmonology (AREA)
- Gastroenterology & Hepatology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Plant Pathology (AREA)
- Oncology (AREA)
- Physics & Mathematics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
LOS VECTORES COMPRENDEN UN GENOMA VIRAL DEFECTIVO RECOMBINANTE QUE EXPRESA AL MENOS UN ANTIGENO ADECUADO PARA LA INDUCCION DE RESPUESTAS INMUNES SISTEMICAS Y SECRETORAS. EL GENOMA VIRAL DEFECTIVO COMPRENDE EL GENOMA DE UN VIRUS PARENTAL QUE TIENE LAS SEÑALES DE RECONOCIMIENTO DE LA REPLICASA VIRAL LOCALIZADAS EN LOS EXTREMOS (3'') Y (5''), QUE COMPRENDE ADEMAS DELACIONES INTERNAS, Y EN DONDE DICHO GENOMA VIRAL DEFECTIVO DEPENDE DE UN VIRUS COMPLEMENTADOR PARA SU REPLICACION. ESTOS VECTORES SON ADECUADOS PARA FORMAR UN SISTEMA RECOMBINANTE QUE COMPRENDE (A) DICHO VECTOR DE EXPRESION, Y (B) UN VIRUS COMPLEMENTADOR QUE PROPORCIONA LAS PROTEINAS FUNCIONALES Y ESTRUCTURALES PARA LA REPLICACION Y ENCAPSIDACION DEL GENOMA DEFECTIVO. ESTE SISTEMA ES ADECUADO PARA LA ELABORACION DE VACUNAS MONO Y POLIVALENTES FRENTE AGENTES INFECCIOSOS DE DISTINTAS ESPECIES ANIMALES, ESPECIALMENTE CERDOS, PERROS Y GATOS.
Priority Applications (16)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES9600620A ES2109189B1 (es) | 1996-03-14 | 1996-03-14 | Vectores basados en genomas virales defectivos recombinantes y su empleo en la formulacion de vacunas. |
BR9708061A BR9708061A (pt) | 1996-03-14 | 1997-03-12 | Vetores baseados em genomas virais defeituosos recombinantes, e seu uso na formação de vacinas. |
EP19970907111 EP1008652A1 (en) | 1996-03-14 | 1997-03-12 | Vectors based on recombinant defective viral genomes, and their use in the formulation of vaccines |
JP53230497A JP3769300B2 (ja) | 1996-03-14 | 1997-03-12 | 組換え欠陥ウイルスゲノムに基づくベクター及びワクチン製剤におけるそれらの使用 |
HU0000356A HUP0000356A3 (en) | 1996-03-14 | 1997-03-12 | Vectors based on recombinant defective viral genomes,and their use in the formulation of vaccines |
US09/155,003 US7041300B1 (en) | 1996-03-14 | 1997-03-12 | Vectors based on recombinant defective viral genomes, and their use in the formulation of vaccines |
CNB971946140A CN1318596C (zh) | 1996-03-14 | 1997-03-12 | 基于重组缺损病毒基因组的载体及其在疫苗制剂中的应用 |
PL97328791A PL188546B1 (pl) | 1996-03-14 | 1997-03-12 | Wektor ekspresyjny antygenów lub przeciwciał, rekombinacyjny układ ekspresyjny i szczepionka do ochrony zwierząt |
CA 2248978 CA2248978A1 (en) | 1996-03-14 | 1997-03-12 | Vectors based on recombinant defective viral genomes, and their use in the formulation of vaccines |
RU98118555A RU2199584C2 (ru) | 1996-03-14 | 1997-03-12 | Вектор (варианты), основанный на рекомбинантном дефектном вирусном геноме, и его применение для создания препаратов вакцин |
EP20060013756 EP1741789A1 (en) | 1996-03-14 | 1997-03-12 | Vectors based on recombinant defective viral genomes, and their use in the formulation of vaccines |
PCT/ES1997/000059 WO1997034008A1 (es) | 1996-03-14 | 1997-03-12 | Vectores basados en genomas virales defectivos recombinantes y su empleo en la formulacion de vacunas |
AU19277/97A AU729044B2 (en) | 1996-03-14 | 1997-03-12 | Vectors based on recombinant defective viral genomes, and their use in the formulation of vaccines |
KR10-1998-0707192A KR100360327B1 (ko) | 1996-03-14 | 1997-03-12 | 재조합결함성바이러스게놈계벡터및이들벡터를백신의제형화에사용하는방법 |
US10/444,059 US20040052775A1 (en) | 1996-03-14 | 2003-05-23 | Vectors based on recombinant defective viral genomes and their use in the formulation of vaccines |
US11/503,214 US20070048862A1 (en) | 1996-03-14 | 2006-08-14 | Vectors based on recombinant defective viral genomes and their use in the formulation of vaccines |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES9600620A ES2109189B1 (es) | 1996-03-14 | 1996-03-14 | Vectores basados en genomas virales defectivos recombinantes y su empleo en la formulacion de vacunas. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2109189A1 ES2109189A1 (es) | 1998-01-01 |
ES2109189B1 true ES2109189B1 (es) | 1998-05-16 |
Family
ID=8294176
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES9600620A Expired - Fee Related ES2109189B1 (es) | 1996-03-14 | 1996-03-14 | Vectores basados en genomas virales defectivos recombinantes y su empleo en la formulacion de vacunas. |
Country Status (13)
Country | Link |
---|---|
US (3) | US7041300B1 (es) |
EP (2) | EP1008652A1 (es) |
JP (1) | JP3769300B2 (es) |
KR (1) | KR100360327B1 (es) |
CN (1) | CN1318596C (es) |
AU (1) | AU729044B2 (es) |
BR (1) | BR9708061A (es) |
CA (1) | CA2248978A1 (es) |
ES (1) | ES2109189B1 (es) |
HU (1) | HUP0000356A3 (es) |
PL (1) | PL188546B1 (es) |
RU (1) | RU2199584C2 (es) |
WO (1) | WO1997034008A1 (es) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ515993A (en) * | 1999-06-10 | 2004-04-30 | Merial Sas | DNA vaccines for pets and sport animals |
ES2170622B1 (es) * | 1999-12-03 | 2004-05-16 | Consejo Superior De Investigaciones Cientificas | Clones y vectores infectivos derivados de coronavirus y sus aplicaciones. |
US6764685B1 (en) | 2000-03-21 | 2004-07-20 | Medimmune Vaccines, Inc. | Recombinant parainfluenza virus expression systems and vaccines |
DK1351981T3 (da) | 2001-01-19 | 2012-11-26 | Vironovative Bv | Et virus, der forårsager luftvejssygdom hos modtagelige pattedyr |
US8715922B2 (en) | 2001-01-19 | 2014-05-06 | ViroNovative | Virus causing respiratory tract illness in susceptible mammals |
ES2208051B1 (es) * | 2002-01-24 | 2005-08-16 | Consejo Sup. Investig. Cientificas | Secuencia de acido nucleico que comprende la señal de encapsidacion del rna de un coronavirus del grupo 1 y sus aplicaciones. |
AU2003219837B2 (en) | 2002-02-21 | 2009-10-29 | Erasmus University Medical Center Rotterdam | Metapneumovirus strains and their use in vaccine formulations and as vector for expression of antigenic sequences |
JP2007525178A (ja) | 2003-04-25 | 2007-09-06 | メッドイミューン バクシーンズ,インコーポレイティド | メタニューモウイルス株、そのワクチン製剤における用途、抗原性配列の発現のためのベクターとしての用途、並びにウイルス増殖方法 |
AU2005279303B2 (en) * | 2004-09-03 | 2011-10-27 | Consejo Superior De Investigaciones Cientificas | Nucleic acid sequences encoding proteins capable of associating into a virus-like particle |
EP1650308A1 (en) * | 2004-09-03 | 2006-04-26 | Consejo Superior De Investigaciones Cientificas | Nucleic acid sequences encoding proteins capable of associating into a virus-like particle |
US11865172B2 (en) | 2005-04-21 | 2024-01-09 | University Of Florida Research Foundation, Inc. | Materials and methods for respiratory disease control in canines |
US7959929B2 (en) | 2005-04-21 | 2011-06-14 | University Of Florida Research Foundation, Inc. | Materials and methods for respiratory disease control in canines |
US20090304738A1 (en) * | 2005-06-16 | 2009-12-10 | Moran Thomas M | Methods for Enhancing Immune Responses |
EP1792996A1 (en) * | 2005-12-01 | 2007-06-06 | Consejo Superior de Investigaciones Cientificas | Nucleic acid sequences encoding vaccines against Porcine reproductive and respiratory syndrome virus (PRRSV) |
US7682619B2 (en) | 2006-04-06 | 2010-03-23 | Cornell Research Foundation, Inc. | Canine influenza virus |
BRPI0800485B8 (pt) * | 2008-01-17 | 2021-05-25 | Univ Minas Gerais | vetores virais recombinantes, composição vacinal para leishmaniose e método de vacinação para leishmaniose |
EP2353610A4 (en) * | 2008-11-19 | 2013-12-11 | Avi Mex S A De C V Lab | RECOMBINANT INACTIVATED VIRUS VECTOR VACCINE |
CN104262488B (zh) * | 2014-09-24 | 2017-07-28 | 普莱柯生物工程股份有限公司 | 一种融合蛋白及其疫苗组合物的制备与应用 |
AU2021240432A1 (en) * | 2020-03-27 | 2022-12-01 | Institut Pasteur | Defective interfering viral genomes |
EP4136218A1 (en) * | 2020-04-12 | 2023-02-22 | Novoscope IP Limited | Particles, dna & rna |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5166057A (en) * | 1989-08-28 | 1992-11-24 | The Mount Sinai School Of Medicine Of The City University Of New York | Recombinant negative strand rna virus expression-systems |
ATE174929T1 (de) * | 1993-01-23 | 1999-01-15 | Inmunologia & Genetica Aplic | Synthetischen peptiden und impfstoffe gegen parvovirus |
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1996
- 1996-03-14 ES ES9600620A patent/ES2109189B1/es not_active Expired - Fee Related
-
1997
- 1997-03-12 JP JP53230497A patent/JP3769300B2/ja not_active Expired - Fee Related
- 1997-03-12 BR BR9708061A patent/BR9708061A/pt not_active Application Discontinuation
- 1997-03-12 WO PCT/ES1997/000059 patent/WO1997034008A1/es active IP Right Grant
- 1997-03-12 AU AU19277/97A patent/AU729044B2/en not_active Ceased
- 1997-03-12 EP EP19970907111 patent/EP1008652A1/en not_active Withdrawn
- 1997-03-12 US US09/155,003 patent/US7041300B1/en not_active Expired - Fee Related
- 1997-03-12 EP EP20060013756 patent/EP1741789A1/en not_active Withdrawn
- 1997-03-12 PL PL97328791A patent/PL188546B1/pl not_active IP Right Cessation
- 1997-03-12 RU RU98118555A patent/RU2199584C2/ru not_active IP Right Cessation
- 1997-03-12 CN CNB971946140A patent/CN1318596C/zh not_active Expired - Fee Related
- 1997-03-12 CA CA 2248978 patent/CA2248978A1/en not_active Abandoned
- 1997-03-12 HU HU0000356A patent/HUP0000356A3/hu unknown
- 1997-03-12 KR KR10-1998-0707192A patent/KR100360327B1/ko not_active IP Right Cessation
-
2003
- 2003-05-23 US US10/444,059 patent/US20040052775A1/en not_active Abandoned
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2006
- 2006-08-14 US US11/503,214 patent/US20070048862A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US7041300B1 (en) | 2006-05-09 |
PL328791A1 (en) | 1999-02-15 |
US20070048862A1 (en) | 2007-03-01 |
CA2248978A1 (en) | 1997-09-18 |
EP1741789A1 (en) | 2007-01-10 |
CN1318596C (zh) | 2007-05-30 |
HUP0000356A2 (hu) | 2000-06-28 |
JP3769300B2 (ja) | 2006-04-19 |
KR100360327B1 (ko) | 2003-03-28 |
KR19990087724A (ko) | 1999-12-27 |
HUP0000356A3 (en) | 2001-09-28 |
RU2199584C2 (ru) | 2003-02-27 |
US20040052775A1 (en) | 2004-03-18 |
WO1997034008A1 (es) | 1997-09-18 |
JP2000513565A (ja) | 2000-10-17 |
AU729044B2 (en) | 2001-01-25 |
ES2109189A1 (es) | 1998-01-01 |
PL188546B1 (pl) | 2005-02-28 |
AU1927797A (en) | 1997-10-01 |
EP1008652A1 (en) | 2000-06-14 |
CN1218513A (zh) | 1999-06-02 |
BR9708061A (pt) | 2000-01-04 |
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