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ES2178121T3 - Derivado de 2-fenil-2-(2-piperidiniliden) acetato y un procedimiento para fabricar el mismo, y procedimiento para fabricar un derivado de 2-fenil-2-(2-piperidinil) acetato opticamente activo para la hidrogenacion asimetrica. - Google Patents

Derivado de 2-fenil-2-(2-piperidiniliden) acetato y un procedimiento para fabricar el mismo, y procedimiento para fabricar un derivado de 2-fenil-2-(2-piperidinil) acetato opticamente activo para la hidrogenacion asimetrica.

Info

Publication number
ES2178121T3
ES2178121T3 ES98400387T ES98400387T ES2178121T3 ES 2178121 T3 ES2178121 T3 ES 2178121T3 ES 98400387 T ES98400387 T ES 98400387T ES 98400387 T ES98400387 T ES 98400387T ES 2178121 T3 ES2178121 T3 ES 2178121T3
Authority
ES
Spain
Prior art keywords
derivative
phenyl
acetate
procedure
manufacturing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES98400387T
Other languages
English (en)
Inventor
Nobuo Seido
Takenobu Nishikawa
Tsukasa Sotoguchi
Yoshifumi Yuasa
Takashi Miura
Hidenori Kumobayashi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takasago International Corp
Original Assignee
Takasago International Corp
Takasago Perfumery Industry Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP09072570A external-priority patent/JP3088328B2/ja
Priority claimed from JP09117358A external-priority patent/JP3088334B2/ja
Application filed by Takasago International Corp, Takasago Perfumery Industry Co filed Critical Takasago International Corp
Application granted granted Critical
Publication of ES2178121T3 publication Critical patent/ES2178121T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

SE PRESENTA UN DERIVADO 2 - FENIL - 2 - (2 - PIPERIDINILIDENO) ACETATO DE FORMULA (1) ADECUADO PARA SER UTILIZADO COMO MATERIA PRIMA DE UN DERIVADO 2 - FENIL - 2 - (2 - PIPERIDINIL) ACETATO DE FORMULA (3) Y UN PROCESO DE PRODUCCION DEL MISMO. SE PRESENTA TAMBIEN UN PROCESO DE PRODUCCION DE UN DERIVADO OPTICAMENTE ACTIVO 2 - FENIL - 2 - (2 - PIPERIDINIL) ACETATO QUE ES UN INTERMEDIARIO PRINCIPAL DE UN ANTIDEPRESIVO. EL DERIVADO 2 FENIL - 2 - (2 - PIPERIDINILIDENO) ACETATO SE PRODUCE MEDIANTE LA CICLACION DE UN DERIVADO 7 - (N-SUSTITUIDO AMINO) - 3 - OXO 2 - HEPTANOATO DE FORMULA (2). EL DERIVADO OPTICAMENTE ACTIVO 2 - FENIL - 2 - (2 - PIPERIDINIL) ACETATO SE PRODUCE MEDIANTE HIDROGENACION ASIMETRICA DEL DERIVADO 2 - FENIL - 2 - (2 PIPERIDINILIDENO) ACETATO EN PRESENCIA DE UN COMPLEJO DE UN METAL DE TRANSICION DEL GRUPO VIII O DE UN ACIDO.
ES98400387T 1997-02-19 1998-02-18 Derivado de 2-fenil-2-(2-piperidiniliden) acetato y un procedimiento para fabricar el mismo, y procedimiento para fabricar un derivado de 2-fenil-2-(2-piperidinil) acetato opticamente activo para la hidrogenacion asimetrica. Expired - Lifetime ES2178121T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP09072570A JP3088328B2 (ja) 1997-02-19 1997-02-19 光学活性２−フェニル−２−（２’−ピペリジニル） 酢酸エステル誘導体の製造方法
JP09117358A JP3088334B2 (ja) 1997-04-02 1997-04-02 ２−フェニル−２−（２’−ピペリジニリデン）酢酸 エステル誘導体およびその誘導体の製造方法

Publications (1)

Publication Number Publication Date
ES2178121T3 true ES2178121T3 (es) 2002-12-16

Family

ID=26413698

Family Applications (1)

Application Number Title Priority Date Filing Date
ES98400387T Expired - Lifetime ES2178121T3 (es) 1997-02-19 1998-02-18 Derivado de 2-fenil-2-(2-piperidiniliden) acetato y un procedimiento para fabricar el mismo, y procedimiento para fabricar un derivado de 2-fenil-2-(2-piperidinil) acetato opticamente activo para la hidrogenacion asimetrica.

Country Status (5)

Country Link
US (1) US5859249A (es)
EP (1) EP0860432B1 (es)
CA (1) CA2211934C (es)
DE (1) DE69805676T2 (es)
ES (1) ES2178121T3 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6025502A (en) * 1999-03-19 2000-02-15 The Trustees Of The University Of Pennsylvania Enantopselective synthesis of methyl phenidate
US20030170181A1 (en) * 1999-04-06 2003-09-11 Midha Kamal K. Method for preventing abuse of methylphenidate
EP1191924A4 (en) 1999-04-06 2005-02-09 Pharmaquest Ltd PHARMACEUTICAL DOSAGE FORM FOR INTERMITTENT ADMINISTRATION OF (D-THREO) -METHYLPHENIDATE AND A SECOND STIMULANT OF THE CENTRAL NERVOUS SYSTEM
ES2544579T3 (es) * 2002-07-30 2015-09-01 Takasago International Corporation Procedimiento de producción de un beta-aminoácido ópticamente activo
JP4040602B2 (ja) * 2004-05-14 2008-01-30 Ｎｅｃエレクトロニクス株式会社 半導体装置
US20060183773A1 (en) * 2005-01-20 2006-08-17 David Bar-Or Uses of methylphenidate derivatives
US20060189655A1 (en) * 2005-01-20 2006-08-24 David Bar-Or Methylphenidate derivatives and uses of them
JP5856843B2 (ja) 2008-05-27 2016-02-10 アンピオ ファーマシューティカルズ，インコーポレイテッド ジケトピペラジンを用いた医薬組成物
CN115322141B (zh) * 2022-09-01 2024-04-16 凯特立斯（深圳）科技有限公司 一种不对称氢化制备手性哌甲酯类化合物的方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2507631A (en) * 1944-01-19 1950-05-16 Ciba Pharm Prod Inc Pyridine and piperidine compounds and process of making same
US2957880A (en) * 1953-12-23 1960-10-25 Ciba Pharm Prod Inc Process for the conversion of stereoisomers
GB9606417D0 (en) * 1996-03-27 1996-06-05 Chiroscience Ltd Asymmetric cyclisation

Also Published As

Publication number Publication date
US5859249A (en) 1999-01-12
CA2211934C (en) 2005-10-18
CA2211934A1 (en) 1998-08-19
EP0860432A1 (en) 1998-08-26
DE69805676T2 (de) 2003-01-23
EP0860432B1 (en) 2002-06-05
DE69805676D1 (de) 2002-07-11

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