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ES2164447T3 - Procedimiento de inhibicion de resorcion del hueso. - Google Patents

Procedimiento de inhibicion de resorcion del hueso.

Info

Publication number
ES2164447T3
ES2164447T3 ES98935752T ES98935752T ES2164447T3 ES 2164447 T3 ES2164447 T3 ES 2164447T3 ES 98935752 T ES98935752 T ES 98935752T ES 98935752 T ES98935752 T ES 98935752T ES 2164447 T3 ES2164447 T3 ES 2164447T3
Authority
ES
Spain
Prior art keywords
resortion
bone
inhibition procedure
inhibition
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES98935752T
Other languages
English (en)
Inventor
Anastasia G Daifotis
Arthur C Ii Santora
A John Yates
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27451690&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2164447(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GBGB9717590.5A external-priority patent/GB9717590D0/en
Priority claimed from GBGB9717850.3A external-priority patent/GB9717850D0/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Application granted granted Critical
Publication of ES2164447T3 publication Critical patent/ES2164447T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • A61K31/663—Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Fittings On The Vehicle Exterior For Carrying Loads, And Devices For Holding Or Mounting Articles (AREA)
  • Pit Excavations, Shoring, Fill Or Stabilisation Of Slopes (AREA)
  • Aiming, Guidance, Guns With A Light Source, Armor, Camouflage, And Targets (AREA)
  • Saccharide Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

La invención se refiere a procedimientos de inhibición de resorción ósea en los mamíferos a la vez que se minimiza la aparición o el riesgo de efectos secundarios gastrointestinales. La invenciones refiere también a las composiciones farmacéuticas y los conjuntos que permiten la puesta en práctica de los procedimientos terapéuticos.
ES98935752T 1997-07-22 1998-07-17 Procedimiento de inhibicion de resorcion del hueso. Expired - Lifetime ES2164447T3 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US5335197P 1997-07-22 1997-07-22
US5353597P 1997-07-23 1997-07-23
GBGB9717590.5A GB9717590D0 (en) 1997-08-20 1997-08-20 Oral method for treating or preventing abnormal bone resorption
GBGB9717850.3A GB9717850D0 (en) 1997-08-22 1997-08-22 Oral method for treating or preventing abnormal bone resorption

Publications (1)

Publication Number Publication Date
ES2164447T3 true ES2164447T3 (es) 2002-02-16

Family

ID=27451690

Family Applications (3)

Application Number Title Priority Date Filing Date
ES01201910T Pending ES2253136T1 (es) 1997-07-22 1998-07-17 Procedimiento para inhibir la resorcion osea.
ES01201913T Expired - Lifetime ES2269014T3 (es) 1997-07-22 1998-07-17 Procedimiento para inhibir la resorcion osea.
ES98935752T Expired - Lifetime ES2164447T3 (es) 1997-07-22 1998-07-17 Procedimiento de inhibicion de resorcion del hueso.

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES01201910T Pending ES2253136T1 (es) 1997-07-22 1998-07-17 Procedimiento para inhibir la resorcion osea.
ES01201913T Expired - Lifetime ES2269014T3 (es) 1997-07-22 1998-07-17 Procedimiento para inhibir la resorcion osea.

Country Status (31)

Country Link
EP (5) EP1151752A3 (es)
JP (2) JP3479780B2 (es)
KR (3) KR20030097610A (es)
CN (3) CN1602879A (es)
AT (2) ATE357921T1 (es)
AU (1) AU8493698A (es)
BG (1) BG66282B1 (es)
BR (1) BR9810779A (es)
CA (1) CA2294595C (es)
CY (2) CY1107535T1 (es)
DE (6) DE01201913T1 (es)
DK (2) DK0998292T3 (es)
EA (1) EA004544B2 (es)
EE (1) EE05603B1 (es)
ES (3) ES2253136T1 (es)
HK (5) HK1024166A1 (es)
ID (1) ID24096A (es)
IL (1) IL133535A0 (es)
IS (3) IS5315A (es)
LU (2) LU91222I2 (es)
NL (2) NL300223I1 (es)
NO (1) NO20000323L (es)
NZ (1) NZ501807A (es)
PL (1) PL195272B1 (es)
PT (2) PT1175904E (es)
SG (2) SG109478A1 (es)
SI (1) SI0998292T1 (es)
SK (1) SK932000A3 (es)
TR (1) TR200000145T2 (es)
UY (1) UY25950A1 (es)
WO (1) WO1999004773A2 (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100609256B1 (ko) * 1998-12-25 2006-08-04 아스텔라스세이야쿠 가부시키가이샤 다발성 골수종의 골 병변 치료용 의약 조성물
PL351674A1 (en) * 1999-05-21 2003-05-19 Novartis Ag Use of bisphosphonic acids for treating angiogenesis
DE60043648D1 (de) * 1999-07-19 2010-02-25 Toray Industries Medikamente zur behandlung von periodontalen erkrankungen
AU2580001A (en) 1999-12-20 2001-07-03 Merck & Co., Inc. Blister package for pharmaceutical treatment card
AU2270101A (en) * 1999-12-20 2001-07-03 Merck & Co., Inc. Pharmaceutical kit
CN1446093A (zh) * 2000-04-07 2003-10-01 得克萨斯系统大学董事会 两性离子型磷脂和双膦酸酯的独特组合物及其作为降低肠胃毒性的双膦酸酯释放系统的应用
JP4722375B2 (ja) 2000-06-20 2011-07-13 ノバルティス アーゲー ビホスホネートの投与法
US6638920B2 (en) * 2000-07-21 2003-10-28 Merck & Co., Inc. Compositions and methods of preventing or reducing the risk or incidence of skeletal injuries in horses
SE0101379D0 (sv) 2001-04-18 2001-04-18 Diabact Ab Komposition som hämmar utsöndring av magsyra
PT1392325E (pt) * 2001-05-02 2006-10-31 Novartis Ag Metodo de administracao de bifosfonatos por inalacao no tratamento ou na prevencao da reabsorcao ossea e da osteoporose
PL399493A1 (pl) 2002-05-10 2012-11-05 F. Hoffmann-La Roche Ag Kwasy bisfosfonowe do leczenia i profilaktyki osteoporozy
SE0203065D0 (sv) * 2002-10-16 2002-10-16 Diabact Ab Gastric acid secretion inhibiting composition
NZ545804A (en) * 2003-09-19 2009-09-25 Wisconsin Alumni Res Found Pharmaceutical compositions and methods comprising combinations of 2-alkylidene-19-or-vitamin D derivatives and a bisphosphonate
JPWO2005072747A1 (ja) * 2004-02-02 2007-09-13 小野薬品工業株式会社 骨吸収抑制剤
BRPI0615770A2 (pt) * 2005-09-16 2011-05-24 Selamine Ltd formulação de bisfosfonato
CA2820019A1 (en) * 2010-12-06 2012-06-14 Effrx Pharmaceuticals Sa Stable effervescent bisphosphonate formulations with rapid solubilization characteristics
CN106924257B (zh) * 2017-03-14 2019-11-19 湖南赛隆药业有限公司 质子泵抑制剂和抗骨质疏松药的复合物及其用途

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL84731A0 (en) * 1986-12-19 1988-05-31 Norwich Eaton Pharma Heterocycle-substituted diphosphonic acids and salts and esters and pharmaceutical compositions containing them
SE8704436D0 (sv) * 1987-11-13 1987-11-13 Pm Konsult Handelsbolag Anvendning av antisekretoriska substanser for nya indikationer
DK0521388T3 (da) * 1991-07-01 1995-09-11 Gergely Gerhard Fremgangsmåde til fremstilling af et farmaceutisk præparat med mindst to forskellige aktivstoffer samt anvendelsen af et sådant præparat
CZ282760B6 (cs) * 1991-11-22 1997-09-17 Procter And Gamble Pharmaceuticals, Inc. Risedronátové prostředky se zpožděným uvolňováním
US5270365A (en) * 1991-12-17 1993-12-14 Merck & Co., Inc. Prevention and treatment of periodontal disease with alendronate
US5294433A (en) * 1992-04-15 1994-03-15 The Procter & Gamble Company Use of H-2 antagonists for treatment of gingivitis
ATE161423T1 (de) * 1992-06-30 1998-01-15 Procter & Gamble Pharma Verwendung von phosphinate zur behandlung der osteoporose
US5431920A (en) * 1993-09-21 1995-07-11 Merck Frosst, Canada, Inc. Enteric coated oral compositions containing bisphosphonic acid antihypercalcemic agents
US5646134A (en) * 1994-04-21 1997-07-08 Merck & Co., Inc. Alendronate therapy to prevent loosening of, or pain associated with, orthopedic implant devices
AU703887B2 (en) * 1995-06-06 1999-04-01 Merck & Co., Inc. Bisphosphonate therapy for bone loss associated with rheumatoid arthritis
CA2254060C (en) * 1996-05-17 2007-05-01 Merck & Co., Inc. Effervescent bisphosphonate formulation

Also Published As

Publication number Publication date
WO1999004773A9 (en) 1999-10-28
UY25950A1 (es) 2000-09-29
TR200000145T2 (tr) 2000-05-22
DE69803291T2 (de) 2002-08-08
NO20000323D0 (no) 2000-01-21
SG139556A1 (en) 2008-02-29
EA004544B2 (ru) 2006-12-29
DE69837450D1 (de) 2007-05-10
DK0998292T3 (da) 2002-05-13
KR20030097611A (ko) 2003-12-31
BG104093A (en) 2000-10-31
IS5315A (is) 1999-12-21
HK1042232A1 (zh) 2002-08-09
WO1999004773A2 (en) 1999-02-04
JP3479780B2 (ja) 2003-12-15
NO20000323L (no) 2000-03-20
CN1166365C (zh) 2004-09-15
CY1107535T1 (el) 2012-01-25
EE05603B1 (et) 2012-12-17
PL195272B1 (pl) 2007-08-31
KR20010022110A (ko) 2001-03-15
LU91222I2 (fr) 2006-04-18
DE122007000063I1 (de) 2007-12-20
CA2294595A1 (en) 1999-02-04
ES2269014T3 (es) 2007-05-01
DK1175904T3 (da) 2007-05-07
HK1042230A1 (zh) 2002-08-09
ES2253136T1 (es) 2006-06-01
ID24096A (id) 2000-07-06
EP0998292A2 (en) 2000-05-10
SK932000A3 (en) 2000-09-12
EE200000040A (et) 2000-10-16
CY2007022I1 (el) 2012-01-25
HK1040495A1 (zh) 2002-06-14
EA200000151A1 (ru) 2000-10-30
EP1175904B1 (en) 2007-03-28
NL300292I1 (nl) 2007-11-01
EP1151752A2 (en) 2001-11-07
BR9810779A (pt) 2000-07-25
DE69837450T2 (de) 2007-08-23
NL300223I1 (nl) 2006-04-03
ATE357921T1 (de) 2007-04-15
EP1175904A2 (en) 2002-01-30
WO1999004773A3 (en) 1999-04-15
EP0998292B1 (en) 2001-11-21
CN1602879A (zh) 2005-04-06
KR100391732B1 (ko) 2003-07-16
CA2294595C (en) 2001-08-21
EA004544B1 (ru) 2004-06-24
JP2002502433A (ja) 2002-01-22
CN1602880A (zh) 2005-04-06
BG66282B1 (bg) 2013-01-31
EP1175904A3 (en) 2002-12-18
PT998292E (pt) 2002-04-29
CY2007022I2 (el) 2012-01-25
KR20030097610A (ko) 2003-12-31
EP1175904B8 (en) 2007-05-09
HK1024166A1 (en) 2000-10-05
DE01201911T1 (de) 2007-10-18
IS7230A (is) 2004-04-21
EP1132088A3 (en) 2002-04-24
LU91364I2 (fr) 2007-11-12
CN1265035A (zh) 2000-08-30
CN1299689C (zh) 2007-02-14
PT1175904E (pt) 2007-04-30
DE122006000009I1 (de) 2006-06-14
SI0998292T1 (en) 2002-04-30
NZ501807A (en) 2003-02-28
EP1151752A3 (en) 2002-12-18
ATE209037T1 (de) 2001-12-15
DE01201913T1 (de) 2007-02-08
DE69803291D1 (de) 2002-02-21
IS7231A (is) 2004-04-21
HK1040494A1 (zh) 2002-06-14
PL338635A1 (en) 2000-11-06
EP1132088A2 (en) 2001-09-12
IL133535A0 (en) 2001-04-30
EP1175903A3 (en) 2002-12-18
AU8493698A (en) 1999-02-16
ES2269014T1 (es) 2007-04-01
JP2005068010A (ja) 2005-03-17
SG109478A1 (en) 2005-03-30
EP1175903A2 (en) 2002-01-30

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