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ES2141631T3 - Estabilizacion del hidrocloruro de naloxon. - Google Patents

Estabilizacion del hidrocloruro de naloxon.

Info

Publication number
ES2141631T3
ES2141631T3 ES98905128T ES98905128T ES2141631T3 ES 2141631 T3 ES2141631 T3 ES 2141631T3 ES 98905128 T ES98905128 T ES 98905128T ES 98905128 T ES98905128 T ES 98905128T ES 2141631 T3 ES2141631 T3 ES 2141631T3
Authority
ES
Spain
Prior art keywords
naloxon
hydrochloride
stabilization
sulphite
dinaloxon
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES98905128T
Other languages
English (en)
Inventor
Bernd Raffelsberger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Goedecke GmbH
Original Assignee
Goedecke GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Goedecke GmbH filed Critical Goedecke GmbH
Application granted granted Critical
Publication of ES2141631T3 publication Critical patent/ES2141631T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Emergency Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Inorganic Chemistry (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Detergent Compositions (AREA)
  • Cereal-Derived Products (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Organic Insulating Materials (AREA)
  • Medicinal Preparation (AREA)

Abstract

LA INVENCION TRATA DE UN PROCEDIMIENTO DESTINADO A ESTABILIZAR NALOXON Y SUS SALES INHIBIENDO LA DIMERIZACION DEL NALOXON EN 2,2 - DINALOXON CON AYUDA DE LOS OPORTUNOS ESTABILIZANTES, ENTRE ELLOS DIOXIDO DE AZUFRE Y SULFITO SODICO.
ES98905128T 1997-02-14 1998-02-03 Estabilizacion del hidrocloruro de naloxon. Expired - Lifetime ES2141631T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19705537 1997-02-14

Publications (1)

Publication Number Publication Date
ES2141631T3 true ES2141631T3 (es) 2000-03-16

Family

ID=7820153

Family Applications (1)

Application Number Title Priority Date Filing Date
ES98905128T Expired - Lifetime ES2141631T3 (es) 1997-02-14 1998-02-03 Estabilizacion del hidrocloruro de naloxon.

Country Status (10)

Country Link
EP (1) EP0880352B1 (es)
AT (1) ATE186643T1 (es)
CZ (1) CZ297951B6 (es)
DE (1) DE59800046D1 (es)
ES (1) ES2141631T3 (es)
GR (1) GR3032458T3 (es)
HU (1) HU224964B1 (es)
PL (1) PL190293B1 (es)
SK (1) SK282549B6 (es)
WO (1) WO1998035679A1 (es)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE210983T1 (de) * 1997-11-03 2002-01-15 Stada Arzneimittel Ag Stabilisiertes kombinationsarzneimittel enthaltend naloxone und ein opiatanalgetikum
RS50070B (sr) 1997-12-22 2009-01-22 Euro-Celtique S.A., Oralni dozni oblik sa kombinacijom opijatnog agonista i antagonista
PL341309A1 (en) 1997-12-22 2001-04-09 Euro Celtique Method of preventing overdosage of opioidic preparations
US6375957B1 (en) 1997-12-22 2002-04-23 Euro-Celtique, S.A. Opioid agonist/opioid antagonist/acetaminophen combinations
SI2517710T1 (sl) 2000-02-08 2015-07-31 Euro-Celtique S.A. Oralne formulacije opioidnih agonistov, varne pred zlorabo
US6716449B2 (en) 2000-02-08 2004-04-06 Euro-Celtique S.A. Controlled-release compositions containing opioid agonist and antagonist
CN1525851A (zh) 2001-05-11 2004-09-01 ������ҩ�����޹�˾ 抗滥用阿片样物质控释剂型
IL160222A0 (en) 2001-08-06 2004-07-25 Euro Celtique Sa Opioid agonist formulations with releasable and sequestered antagonist
US20030157168A1 (en) 2001-08-06 2003-08-21 Christopher Breder Sequestered antagonist formulations
US20140271788A1 (en) 2013-03-15 2014-09-18 Monosol Rx, Llc Sublingual and buccal film compositions
EP2289492B1 (en) 2002-03-14 2016-12-07 Euro-Celtique S.A. Naltrexone hydrochloride compositions
ES2546010T3 (es) 2002-04-05 2015-09-17 Euro-Celtique S.A. Preparación farmacéutica que contiene oxicodona y naloxona
EP2422773A3 (en) 2002-09-20 2012-04-18 Alpharma, Inc. Sequestering subunit and related compositions and methods
SI2368553T1 (sl) 2003-04-08 2015-05-29 Progenics Pharmaceuticals, Inc. Farmacevtske formulacije, vsebujoče metilnatrekson
TWI347201B (en) 2003-04-21 2011-08-21 Euro Celtique Sa Pharmaceutical products,uses thereof and methods for preparing the same
EP1604666A1 (en) 2004-06-08 2005-12-14 Euro-Celtique S.A. Opioids for the treatment of the Chronic Obstructive Pulmonary Disease (COPD)
EP1702558A1 (en) 2005-02-28 2006-09-20 Euro-Celtique S.A. Method and device for the assessment of bowel function
HUE031590T2 (en) 2006-06-19 2017-07-28 Alpharma Pharmaceuticals Llc Pharmaceutical preparations
MX2009011554A (es) 2007-04-26 2010-01-25 Toray Industries Preparacion solida estable conteniendo un derivado de 4,5-epoximorfinano.
US8623418B2 (en) 2007-12-17 2014-01-07 Alpharma Pharmaceuticals Llc Pharmaceutical composition
CA2676881C (en) 2008-09-30 2017-04-25 Wyeth Peripheral opioid receptor antagonists and uses thereof
CA2740476C (en) 2008-10-24 2016-04-05 Toray Industries, Inc. Stable tablet containing 4,5-epoxymorphinan derivative
TR201900199T4 (tr) 2009-03-10 2019-02-21 Euro Celtique Sa Oksikodon ve nalokson içeren çabuk salımlı farmasötik bileşimler.
TWI605814B (zh) 2010-03-11 2017-11-21 惠氏有限責任公司 甲基拿淬松（ｍｅｔｈｙｌｎａｌｔｒｅｘｏｎｅ）之口服製劑及親脂性鹽
ES2642788T3 (es) 2010-05-10 2017-11-20 Euro-Celtique S.A. Fabricación de gránulos sin principio activo y de comprimidos que comprenden los mismos
WO2011141490A1 (en) 2010-05-10 2011-11-17 Euro-Celtique S.A. Combination of active loaded granules with additional actives
CA2881144A1 (en) * 2012-11-09 2014-05-09 Purdue Pharma Pharmaceutical compositions comprising hydromorphone and naloxone
UA116567C2 (uk) 2013-07-23 2018-04-10 Євро-Селтік С.А. Комбінація оксикодону та налоксону для застосування в лікуванні болю у пацієнтів, які страждають від болю та захворювання, що призводить до дисбактеріозу кишечнику та/або підвищує ризик кишкової бактеріальної транслокації
EA030310B1 (ru) 2013-11-13 2018-07-31 Эро-Селтик С.А. Гидроморфон и налоксон для лечения боли и индуцированного опиоидами синдрома дисфункции кишечника
WO2015095644A1 (en) 2013-12-20 2015-06-25 AntiOP, Inc. Intranasal naloxone compositions and methods of making and using same
US11135155B2 (en) 2014-07-08 2021-10-05 Hikma Pharmaceuticals Usa Inc. Liquid naloxone spray
WO2016007245A1 (en) * 2014-07-08 2016-01-14 Insys Pharma, Inc. Sublingual naloxone spray

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CS276692B6 (cs) * 1990-08-29 1992-07-15 Z Presneho Strojirenstvi Zařízení k řazení hřebíků v násypce plníce
JPH07267862A (ja) * 1994-03-29 1995-10-17 Sekisui Chem Co Ltd 経皮吸収貼付剤
DE4423850A1 (de) * 1994-07-07 1996-01-11 Labtec Gmbh Transdermales therapeutisches System zur Applikation von Naloxon
PT914097E (pt) * 1996-03-12 2002-06-28 Alza Corp Composicao e forma de dosagem compreendendo antagonista de opioide

Also Published As

Publication number Publication date
CZ297951B6 (cs) 2007-05-02
SK282549B6 (sk) 2002-10-08
EP0880352A2 (de) 1998-12-02
CZ289699A3 (cs) 2000-02-16
WO1998035679A1 (de) 1998-08-20
DE59800046D1 (de) 1999-12-23
ATE186643T1 (de) 1999-12-15
EP0880352B1 (de) 1999-11-17
HU224964B1 (en) 2006-04-28
HUP0001094A3 (en) 2001-02-28
HUP0001094A2 (hu) 2000-09-28
PL335249A1 (en) 2000-04-10
PL190293B1 (pl) 2005-11-30
GR3032458T3 (en) 2000-05-31
SK109299A3 (en) 2000-08-14

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