EP3356522A4 - Compositions contenant un exosome chargé d'une protéine, et procédés de préparation et d'administration correspondants - Google Patents

Compositions contenant un exosome chargé d'une protéine, et procédés de préparation et d'administration correspondants Download PDF

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Publication number: EP3356522A4
Authority: EP; European Patent Office
Prior art keywords: delivering; preparing; methods; same; compositions containing
Prior art date: 2016-09-30
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP17856859.8A

Other languages

German (de)

English (en)

Other versions

EP3356522A1 (fr

Inventor

Chulhee Choi

Kyungsun CHOI

Seung-Wook RYU

Nambin YIM

Hojun CHOI

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Ilias Biologics Inc

Original Assignee

Cellex Life Sciences Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2016-09-30

Filing date

2017-09-29

Publication date

2019-03-27

2016-09-30 Priority claimed from KR1020160126961A external-priority patent/KR101912315B1/ko

2016-09-30 Priority claimed from KR1020160126335A external-priority patent/KR101877010B1/ko

2016-09-30 Priority claimed from KR1020160126921A external-priority patent/KR101912313B1/ko

2016-10-04 Priority claimed from KR1020160127486A external-priority patent/KR101912310B1/ko

2016-10-13 Priority claimed from KR1020160132616A external-priority patent/KR101900465B1/ko

2017-09-29 Application filed by Cellex Life Sciences Inc filed Critical Cellex Life Sciences Inc

2018-08-08 Publication of EP3356522A1 publication Critical patent/EP3356522A1/fr

2019-03-27 Publication of EP3356522A4 publication Critical patent/EP3356522A4/fr

Status Withdrawn legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- A61K38/1761—Apoptosis related proteins, e.g. Apoptotic protease-activating factor-1 (APAF-1), Bax, Bax-inhibitory protein(s)(BI; bax-I), Myeloid cell leukemia associated protein (MCL-1), Inhibitor of apoptosis [IAP] or Bcl-2
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/44—Oxidoreductases (1)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y111/00—Oxidoreductases acting on a peroxide as acceptor (1.11)
- C12Y111/01—Peroxidases (1.11.1)
- C12Y111/01015—Peroxiredoxin (1.11.1.15)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01045—Glucosylceramidase (3.2.1.45), i.e. beta-glucocerebrosidase
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/22—Ribonucleases RNAses, DNAses
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)

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Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Zoology (AREA)
Medicinal Chemistry (AREA)
Wood Science & Technology (AREA)
General Engineering & Computer Science (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Biomedical Technology (AREA)
Epidemiology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Gastroenterology & Hepatology (AREA)
Biophysics (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Microbiology (AREA)
Immunology (AREA)
Physics & Mathematics (AREA)
Plant Pathology (AREA)
Marine Sciences & Fisheries (AREA)
Hematology (AREA)
Toxicology (AREA)
Diabetes (AREA)
Mycology (AREA)
Rheumatology (AREA)
Pain & Pain Management (AREA)
Obesity (AREA)
Oncology (AREA)

EP17856859.8A 2016-09-30 2017-09-29 Compositions contenant un exosome chargé d'une protéine, et procédés de préparation et d'administration correspondants Withdrawn EP3356522A4 (fr)

Applications Claiming Priority (7)

Application Number	Priority Date	Filing Date	Title
KR1020160126961A KR101912315B1 (ko)	2016-09-30	2016-09-30	Bax 단백질을 포함하는 엑소솜의 제조 방법 및 상기 제조 방법에 의해 제조된 엑소솜을 유효성분으로 함유하는 암 예방 및 치료용 약학적 조성물
KR1020160126335A KR101877010B1 (ko)	2016-09-30	2016-09-30	super-repressor-IκB 단백질을 포함하는 엑소솜의 제조 방법 및 상기 제조 방법에 의해 제조된 엑소솜을 유효성분으로 함유하는 염증성 질환 예방 및 치료용 약학적 조성물
KR1020160126921A KR101912313B1 (ko)	2016-09-30	2016-09-30	Cre 재조합 단백질을 포함하는 엑소솜의 제조 방법 및 상기 제조 방법에 의해 제조된 엑소솜을 유효성분으로 함유하는 표적 유전자의 조건적 녹아웃 대립유전자를 생성하기 위한 조성물
KR1020160127486A KR101912310B1 (ko)	2016-10-04	2016-10-04	페록시레독신 i 또는 ii 단백질을 포함하는 엑소솜의 제조 방법 및 상기 제조 방법에 의해 제조된 엑소솜을 유효성분으로 함유하는 항산화용 약학적 조성물
KR1020160132616A KR101900465B1 (ko)	2016-10-13	2016-10-13	CRISPR-CAS family를 이용한 게놈 에디팅 툴을 엑소솜으로 전달하는 기술
KR20170018637		2017-02-10
PCT/KR2017/011070 WO2018062973A1 (fr)	2016-09-30	2017-09-29	Compositions contenant un exosome chargé d'une protéine, et procédés de préparation et d'administration correspondants

Publications (2)

Publication Number	Publication Date
EP3356522A1 EP3356522A1 (fr)	2018-08-08
EP3356522A4 true EP3356522A4 (fr)	2019-03-27

Family

ID=61760013

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP17856859.8A Withdrawn EP3356522A4 (fr)	2016-09-30	2017-09-29	Compositions contenant un exosome chargé d'une protéine, et procédés de préparation et d'administration correspondants

Country Status (7)

Country	Link
EP (1)	EP3356522A4 (fr)
JP (1)	JP2019528674A (fr)
CN (1)	CN108473973A (fr)
AU (1)	AU2017335084B2 (fr)
CA (1)	CA3002520A1 (fr)
IL (1)	IL259023B (fr)
WO (1)	WO2018062973A1 (fr)

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CN113234686A (zh) *	2021-04-28	2021-08-10	大连干细胞与精准医学创新研究院	一种靶蛋白递送载体的制备方法
CN114878833A (zh) *	2021-07-01	2022-08-09	浙江大学	一种检测抗过氧化物还原酶-1-IgG抗体的试剂盒
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- 2017-09-29 WO PCT/KR2017/011070 patent/WO2018062973A1/fr active Application Filing
- 2017-09-29 IL IL259023A patent/IL259023B/en unknown
- 2017-09-29 JP JP2018530580A patent/JP2019528674A/ja active Pending
- 2017-09-29 CA CA3002520A patent/CA3002520A1/fr active Pending
- 2017-09-29 AU AU2017335084A patent/AU2017335084B2/en active Active
- 2017-09-29 CN CN201780003826.5A patent/CN108473973A/zh active Pending

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Also Published As

Publication number	Publication date
IL259023B (en)	2022-09-01
JP2019528674A (ja)	2019-10-17
WO2018062973A1 (fr)	2018-04-05
CN108473973A (zh)	2018-08-31
IL259023A (en)	2018-07-31
CA3002520A1 (fr)	2018-04-05
EP3356522A1 (fr)	2018-08-08
AU2017335084A1 (en)	2018-05-10
AU2017335084B2 (en)	2023-06-29

Publication	Publication Date	Title
EP3356522A4 (fr)	2019-03-27	Compositions contenant un exosome chargé d'une protéine, et procédés de préparation et d'administration correspondants
IL267033A (en)	2019-07-31	Preparations and methods for administering nucleic acid and/or protein cargo
HK1247854A1 (zh)	2018-10-05	混合變應原組合物及其使用方法
EP3355954A4 (fr)	2020-01-08	Méthodes et compositions d'administration
EP3285594A4 (fr)	2018-12-05	Systèmes d'administration et procédés de préparation de ceux-ci
EP3474857A4 (fr)	2020-03-18	Compositions et méthodes de libération d'agents thérapeutiques
EP3512554A4 (fr)	2020-06-17	Compositions plaquettaires et procédés pour l'administration d'agents thérapeutiques
EP3668552A4 (fr)	2021-04-28	Exosomes pour administration spécifique à une cible et procédés de préparation et d'administration de ceux-ci
EP3305802A4 (fr)	2019-01-09	Nouveau peptide et composition le contenant
EP3548616A4 (fr)	2020-05-13	Modulateurs de tau et procédés et compositions pour leur administration
EP3457869A4 (fr)	2019-05-22	Système de stockage et de distribution
EP3331947A4 (fr)	2019-04-17	Support de biomolécules à base de silice, composition pharmaceutique le comprenant, procédé de préparation et utilisation correspondants
EP3426304A4 (fr)	2019-11-27	Particules de nanolipoprotéine ainsi que compositions, procédés et systèmes associés pour chargement amélioré de médicament
IL265831A (en)	2019-06-30	Preparations and methods for protein expression and administration
EP3515417A4 (fr)	2020-08-05	Dispositifs d'administration et procédés pour les fabriquer
IL268997B1 (en)	2023-05-01	Preparations containing pgi2 receptor agonists and processes for their preparation
EP3479835A4 (fr)	2020-03-25	Composition pour une utilisation dans l'amélioration de l'état nutritionnel
EP3466269A4 (fr)	2020-02-19	Composition contenant de la caféine et de la cycloalanylalanine
EP3468570A4 (fr)	2020-01-01	Compositions pour systèmes biologiques et leurs procédés de préparation et d'utilisation
EP3512529A4 (fr)	2020-05-06	Compositions et procédés d'administration de médicament
EP3341327A4 (fr)	2019-04-24	Compositions d'hydroxyapatite particulaire et leurs procédés de préparation
EP3319930A4 (fr)	2019-04-10	Procédés et compositions pour la stabilisation de protéines
EP3615005A4 (fr)	2021-03-10	Compositions et méthodes d'administration de vaccins
EP3328434A4 (fr)	2019-03-13	Composition pharmaceutique présentant une stabilité de stockage améliorée, et son procédé de préparation
EP3328435A4 (fr)	2019-03-13	Composition pharmaceutique à stabilité au stockage améliorée, et son procédé de préparation

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